1. Serum Concentrations of 7α-hydroxy-4-cholesten-3-one Are Associated With Bile Acid Diarrhea in Patients With Crohn’s Disease
- Author
-
Battat, Robert, Duijvestein, Marjolijn, Vande Casteele, Niels, Singh, Siddharth, Dulai, Parambir S, Valasek, Mark A, Mimms, Larry, McFarland, Judson, Hester, Kelly D, Renshaw, Mark, Jain, Anjali, Sandborn, William J, and Boland, Brigid S
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Nutrition ,Autoimmune Disease ,Clinical Research ,Crohn's Disease ,Digestive Diseases ,Inflammatory Bowel Disease ,Oral and gastrointestinal ,Adult ,Bile Acids and Salts ,Biomarkers ,Cholestenones ,Complement C4 ,Crohn Disease ,Diarrhea ,Female ,Fibroblast Growth Factors ,Humans ,Ileum ,Male ,Steatorrhea ,Noninvasive Test ,Monitoring ,Surgical Complications ,Inflammatory Bowel Diseases ,Gastroenterology & Hepatology ,Clinical sciences - Abstract
Background & aimsPatients with Crohn's disease (CD) often have bile acid diarrhea (BAD), due to bile acid malabsorption following ileal resection (IR). Bile acid malabsorption increases production of 7α-hydroxy-4-cholesten-3-one (C4), a bile acid precursor. We investigated relationships between serum concentrations of C4 and BAD in patients with CD.MethodsWe collected demographic data, serum samples, and information on the presence of diarrhea (>3 liquid bowel movements/day), as well as clinical, endoscopic, and histologic scores from 26 patients with CD and IR, 21 patients with CD without IR, and 37 patients with ulcerative colitis (UC). We compared serum concentrations of C4 and fibroblast growth factor 19 (FGF19) between groups. We performed area under the receiver operating characteristic curve (AUROC) analysis to identify the optimal cutoff C4 concentrations for the diagnosis of diarrhea attributable to bile acid malabsorption (BAD), defined as diarrhea and a serum concentration of FGF19
- Published
- 2019