4,078 results on '"Choledochal cyst"'
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2. Ketamine-midazolam as a Sedative Agent in Endoscopic Retrograde Cholangiopancreatography.
- Author
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Prof Madya Dr. Azlanudin Azman, Associate Professor
- Published
- 2024
3. Diagnostic yield of endoscopic ultrasound in dilated common bile duct with non-diagnostic cross-sectional imaging.
- Author
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Mahajan, Ankit, Das, Kshaunish, Kishalaya, Misra, Debashis, Das, Kausik, and Dhali, Gopal Krishna
- Abstract
Background: Biliary dilatation without obvious etiology on cross sectional imaging warrants further investigation. This study aimed to assess yield of endoscopic ultrasound in providing etiologic diagnosis in such situation. Methods: Prospective cohort of consecutive patients with biliary dilatation & non diagnostic computed tomography (CT) and /or magnetic resonance imaging (MRI) underwent endoscopic ultrasound (EUS) with/without fine needle aspiration cytology (FNAC) and were followed clinically, biochemically with/without radiology for up to six months. The findings of EUS were corroborated with histopathology of surgical specimens and endoscopic retrograde cholangiography (ERCP) findings in relevant cases. Results: Median age of 121 patients completing follow up was 55 years. 98.2% patients were symptomatic and median common bile duct (CBD) diameter was 13 mm. EUS was able to identify lesions attributable for biliary dilatation in (67 out of 121) 55.4% cases with ampullary neoplasm being the commonest (29 out of 67 i.e. 43%). Multivariate logistic regression analysis identified jaundice as the predictor of positive diagnosis on EUS, of finding ampullary lesion and pancreatic lesion on EUS. EUS had sensitivity, specificity, positive predictive value and diagnostic accuracy of 95.65%, 94.23%, 95.65% and 95.04% respectively in providing etiologic diagnosis. Threshold value for baseline bilirubin of 10 mg%, for baseline CA 19.9 of 225 u/L and for largest CBD diameter of 16 mm were determined to have specificity of 98%, 95%, 92.5% respectively of finding a positive diagnosis on EUS. Conclusion: EUS provides considerable diagnostic yield with high accuracy in biliary dilatation when cross sectional imaging fails to provide etiologic diagnosis. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
4. Totally laparoscopic surgery for choledochal cysts with hand-sewn Roux-en-Y reconstruction in a pediatric population.
- Author
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QIANLONG LIU, QIANG YU, JIALU FU, and PENG LI
- Subjects
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LAPAROSCOPIC surgery , *CHILD patients , *MINIMALLY invasive procedures , *PEDIATRIC surgery , *CYSTS (Pathology) , *GASTRIC bypass - Abstract
Cyst excision and Roux-en-Y hepaticojejunostomy (RYHJ) is the standard treatment for choledochal cysts (CCs). In the present study, the results of totally laparoscopic surgery for CCs (TLCCs) in a pediatric population were evaluated. The clinical data of 28 children with CCs between June 2020 and June 2023 were retrospectively reviewed. All patients underwent TLCCs involving cyst excision and RYHJ. The jejunojejunal anastomosis was completed laparoscopically using manual sutures. Age at operation, operative time, postoperative recovery and complications were evaluated. The 28 patients comprised 8 boys and 20 girls who underwent TLCCs at a mean age of 4.2 years (range, 1 month-12.3 years) with a mean weight of 15.9 kg (range, 4.6-43 kg). All patients received ultrasound and magnetic resonance cholangiopancreatography examinations, which revealed a mean cyst diameter and length of 1.74±0.76 cm and 3.85±1.25 cm, respectively. The mean operative time was 214±43.8 min. The mean time until starting an oral diet after surgery was 2.89±1.23 days. Apart from bile leakage and wound infection, no other complications occurred during a median follow-up period of 18 months (range, 4-42 months). TLCCs can be performed safely by skilled surgeons in pediatric patients. TLCCs may be more physiologically compatible and accelerate recovery of intestinal function with reduced trauma and better esthetic outcomes than conventional laparoscopic surgery for CCs. Therefore, TLCCs with manual sutures may be considered as an option for minimally invasive surgery in pediatric patients with CCs. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
5. Antenatally Detected Choledochal Malformation: What Are We Waiting For?
- Author
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Abdelmaksoud, Sherif, Kronfli, Rania, Makin, Erica, and Davenport, Mark
- Abstract
An increasing proportion of congenital choledochal malformation (CCM) are being detected on antenatal ultrasound. However, the actual timing of its surgical correction remains controversial with some series showing an excess of complications the earlier the operation. The aim of this study was to characterize the pathophysiological aspects of this cohort from the perspective of age at surgery in order to inform a more rational basis for clinical decision-making. We analysed a prospective database of CCM acquired over a 26-year period (Jan. 1997 to Dec. 2022) for patient demography; details of pre- and post-natal imaging; age at surgical intervention; operative complications (Clavien-Dindo classification) and outcome. Data are quoted as median (IQR). All comparisons are non-parametric. A P value of 0.05 was accepted as significant. There were 58 (72% female) children with an antenatally-detected CCM from a total of 265 (21.8%) in the series. These were classified as Type 1C (n = 47; 81%), type 4C (n = 3; 5%) and Type 5 (n = 8; 14%). There were no Type 1F lesions in this cohort. Median age at surgery was 113 (IQR 57–198) days. Postnatal cyst (US) size varied from 12 to 130 mm but there was little evidence of a relationship between this and post-natal liver biochemistry (e.g. bilirubin r S = 0.01, P = 0.44; AST r S = 0.14, P = 0.19). Choledochal pressure measurements (n = 46) showed resting pressures of 12 (9–21) mmHg with no significant correlation with age (P = 0.4) or aspartate aminotransferase (P = 0.2) or γ-glutamyl transferase (P = 0.06). The cohort was divided into 2 groups (Early and Late) based on the median age at surgery (all open) (113 days). Biliary obstruction was more common in the Early group (10 vs. 2; P = 0.01). Two perforations occurred, both in the Early group. With a deliberate policy of regular ultrasound-based follow-up we have seen no anastomotic complications (leak, stenosis, persistent intrahepatic biliary dilatation or stones) or post-operative cholangitis in any child [median follow-up 3.42 (1.30–8.05) years]. This is one of the largest series documenting the outcomes of antenatally-detected CCMs, certainly in Europe and North America. Such lesions are invariably cystic in nature, and either Types 1C, 4C or 5. The absence of complications using a policy of early intervention (where possible) in experienced hepatobiliary units was shown. II. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
6. Simultaneous choledochal cyst excision and pancreaticojejunostomy (Puestow's technique) for type IA cyst with associated chronic pancreatitis: a case report.
- Author
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Bashir, Hamza, Abbas, Ali, and Khan, Muhammad Arsalan
- Subjects
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BILIARY tract , *LIVER function tests , *BILE ducts , *SURGICAL excision , *CYSTS (Pathology) , *CHRONIC pancreatitis - Abstract
Introduction and importance: Choledochal cysts are congenital conditions that affect the biliary tree, typically identified during childhood. These cysts present as dilations in the biliary system, occurring either in the extrahepatic or intrahepatic regions or in some cases, in both areas. Occasionally, it may have associated chronic pancreatitis posing a challenge to the management of both conditions. In the case reported, a female child was diagnosed with a choledochal cyst along with chronic pancreatitis. She had an excision of cyst and lateral pancreaticojejunostomy simultaneously for both conditions resulting in favorable outcomes. Case presentation: An 8-year-old child visited the clinic with a complaint of upper abdominal pain accompanied by intermittent vomiting. An ultrasound was performed which showed a dilated common bile duct. To confirm the diagnosis, an MRCP and baseline labs including liver function tests were ordered. The findings were suggestive of a type IA choledochal cyst with concomitant chronic pancreatitis. Subsequently, she had choledochal cyst excision with Roux-en-Y hepaticojejunostomy reconstruction plus lateral pancreaticojejunostomy using the classical Puestow's technique. The patient's recovery post-surgery was uneventful, resulting in discharge on the fifth post-operative day for routine outpatient follow-up. Clinical discussion: Patients afflicted with choledochal cysts are prone to recurrent pancreatitis, though the precise underlying mechanism is unknown. Certain studies propose an association between abnormal pancreatico-biliary junction and recurrent pancreatitis, often defined as a common channel surpassing 15 mm in length. However, this aberration could not be definitively established in the current case. Diagnosis of choledochal cysts can be confirmed through either ERCP or MRCP, with the latter preferred due to its non-invasive nature. The optimal management strategy for choledochal cysts necessitates cyst resection and Roux-en-Y hepaticojejunostomy reconstruction Moreover, in cases associated with chronic pancreatitis, longitudinal pancreatojejunostomy may be undertaken. Conclusion: Thus, it is concluded that although rare choledochal cysts may have associated chronic pancreatitis. Surgical excision of the cyst and lateral pancreaticojejunostomy can be performed simultaneously resulting in favorable post-operative outcomes. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
7. Robot-assisted resection of choledochal cyst in neonates.
- Author
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Chen, Sai, Gao, Zhigang, Chen, Qingjiang, and Qian, Yunzhong
- Subjects
MINIMALLY invasive procedures ,NEWBORN infants ,CYSTS (Pathology) ,SURGICAL robots ,CHILDREN'S hospitals ,NEONATAL surgery - Abstract
Objective: Laparoscopic choledochectomy and hepatojejunostomy have been reported in children since 1995, but this procedure is technically demanding. Robotic surgical systems can simplify complex minimally invasive procedures. Currently, few reports have been made on neonates. We present the experience of 6 cases of neonatal CC(choledochal cysts). Study design: Between January 2022 and December 2023, 6 neonates underwent robotic resection of choledochal cyst and hepaticojejunostomy using the Da Vinci surgical system at Children's Hospital, Zhejiang University School of Medicine, a high-volume hepatobiliary disease center. demographic data of the patients and surgical outcomes were collected and analyzed. Results: All 6 patients were successfully treated by robotic cystectomy and hepaticojejunostomy. The mean age was 17.3 days (range 4–25) and the mean weight was 3.6 kg (range 2.55–4.4). 5 cysts were type Ia and 1 was type Iva. The mean diameter of the cysts was 3.8 cm (range 1.25-5). The mean time to establish feeding was 4.83 days (range 4–6), and patients were discharged after a median time of 16.83 days (range 7–42) without postoperative complications. Conclusions: This procedure is safe and effective for neonates. The authors found that the use of robot-assisted surgery has ergonomic advantages in this delicate, minimally invasive procedure. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
8. Surgical aspects of choledochal cyst in children and adults: an experience of 106 cases.
- Author
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Achatsachat, Pornchai, Intragumheang, Chayutra, Srisan, Nimmita, Decharun, Katawaetee, Rajatapiti, Prapapan, Reukvibunsi, Somboon, Kitisin, Krit, Prichayudh, Supparerk, Pungpapong, Suppa-Ut, Nonthasoot, Bunthoon, Sirichindakul, Pongserath, and Vejchapipat, Paisarn
- Subjects
- *
CHOLANGITIS , *CYSTS (Pathology) , *ADULTS , *ABDOMINAL pain , *MEDICAL screening , *UNIVERSITY hospitals - Abstract
Purpose: To describe clinical features of choledochal cyst (CC) patients in terms of demographic data, clinical presentation, investigations, treatment, and outcomes among children and adults. Methods: The medical records of patients undergoing choledochal cyst (CC) surgery from 2002 to 2021 at a university hospital were retrospectively reviewed. The patients were divided into two groups: children (< 15 years) and adults (≥ 15 years). Descriptive statistics were used. Results: There were 106 cases of CC (Female/male = 88/18, children/adult = 53/53). Abdominal pain was the predominant presenting symptom, followed by jaundice in both groups. Adults were significantly more prone to present with abdominal pain compared to children (86.8% vs. 52.8%; p < 0.001), while children were more likely to experience acholic stool than adults (22.6% vs. 3.8%; p = 0.004). Ultrasound was the preferred investigation screening modality (75.5%). Most patients were presented with type I CC (71.7%). Laparoscopic-assisted approach was performed in 8.5%. CC excision with roux-en-y hepatico-jejunostomy was the main procedure (88.7%). Adults had a higher incidence of post-op complications, including stones, anastomosis stricture, abdominal collection, and cholangitis. Adults were significantly more likely to require intervention after surgery, compared to children (26.4% vs. 5.7%; p = 0.04). Conclusions: Ultrasound was the most common screening tool for diagnosis. Postoperatively, adults with CC experience more serious post-op complications compared to children. This could be attributed to long-standing cystic inflammation. Therefore, prompt definitive surgery is recommended for CC patients. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
9. Choledochal Cyst Diagnosed during Pregnancy and Treated by Postpartum Laparoscopic Choledochal Cyst Excision: Case Report.
- Author
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Tetsuya Shimizu, Yoshiharu Nakamura, Akira Matsushita, Masato Yoshioka, Tomohiro Kanda, Yoshiaki Mizuguchi, and Hiroshi Yoshida
- Subjects
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INTRAHEPATIC bile ducts , *GALLSTONES , *MEDICAL societies , *LEUKOCYTE count , *NATURAL history , *CHOLANGITIS - Published
- 2024
- Full Text
- View/download PDF
10. Simultaneous choledochal cyst excision and pancreaticojejunostomy (Puestow’s technique) for type IA cyst with associated chronic pancreatitis: a case report
- Author
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Hamza Bashir, Ali Abbas, and Muhammad Arsalan Khan
- Subjects
Choledochal cyst ,Puestow’s technique ,Hepaticojejunostomy ,Chronic pancreatitis ,Surgery ,RD1-811 ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Abstract Introduction and importance Choledochal cysts are congenital conditions that affect the biliary tree, typically identified during childhood. These cysts present as dilations in the biliary system, occurring either in the extrahepatic or intrahepatic regions or in some cases, in both areas. Occasionally, it may have associated chronic pancreatitis posing a challenge to the management of both conditions. In the case reported, a female child was diagnosed with a choledochal cyst along with chronic pancreatitis. She had an excision of cyst and lateral pancreaticojejunostomy simultaneously for both conditions resulting in favorable outcomes. Case presentation An 8-year-old child visited the clinic with a complaint of upper abdominal pain accompanied by intermittent vomiting. An ultrasound was performed which showed a dilated common bile duct. To confirm the diagnosis, an MRCP and baseline labs including liver function tests were ordered. The findings were suggestive of a type IA choledochal cyst with concomitant chronic pancreatitis. Subsequently, she had choledochal cyst excision with Roux-en-Y hepaticojejunostomy reconstruction plus lateral pancreaticojejunostomy using the classical Puestow’s technique. The patient’s recovery post-surgery was uneventful, resulting in discharge on the fifth post-operative day for routine outpatient follow-up. Clinical discussion Patients afflicted with choledochal cysts are prone to recurrent pancreatitis, though the precise underlying mechanism is unknown. Certain studies propose an association between abnormal pancreatico-biliary junction and recurrent pancreatitis, often defined as a common channel surpassing 15 mm in length. However, this aberration could not be definitively established in the current case. Diagnosis of choledochal cysts can be confirmed through either ERCP or MRCP, with the latter preferred due to its non-invasive nature. The optimal management strategy for choledochal cysts necessitates cyst resection and Roux-en-Y hepaticojejunostomy reconstruction Moreover, in cases associated with chronic pancreatitis, longitudinal pancreatojejunostomy may be undertaken. Conclusion Thus, it is concluded that although rare choledochal cysts may have associated chronic pancreatitis. Surgical excision of the cyst and lateral pancreaticojejunostomy can be performed simultaneously resulting in favorable post-operative outcomes.
- Published
- 2024
- Full Text
- View/download PDF
11. Robot-assisted resection of choledochal cyst in neonates
- Author
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Sai Chen, Zhigang Gao, Qingjiang Chen, and Yunzhong Qian
- Subjects
Hepatojejunostomy ,Neonate ,Robotic ,Choledochal cyst ,Pediatrics ,RJ1-570 - Abstract
Abstract Objective Laparoscopic choledochectomy and hepatojejunostomy have been reported in children since 1995, but this procedure is technically demanding. Robotic surgical systems can simplify complex minimally invasive procedures. Currently, few reports have been made on neonates. We present the experience of 6 cases of neonatal CC(choledochal cysts). Study design Between January 2022 and December 2023, 6 neonates underwent robotic resection of choledochal cyst and hepaticojejunostomy using the Da Vinci surgical system at Children’s Hospital, Zhejiang University School of Medicine, a high-volume hepatobiliary disease center. demographic data of the patients and surgical outcomes were collected and analyzed. Results All 6 patients were successfully treated by robotic cystectomy and hepaticojejunostomy. The mean age was 17.3 days (range 4–25) and the mean weight was 3.6 kg (range 2.55–4.4). 5 cysts were type Ia and 1 was type Iva. The mean diameter of the cysts was 3.8 cm (range 1.25-5). The mean time to establish feeding was 4.83 days (range 4–6), and patients were discharged after a median time of 16.83 days (range 7–42) without postoperative complications. Conclusions This procedure is safe and effective for neonates. The authors found that the use of robot-assisted surgery has ergonomic advantages in this delicate, minimally invasive procedure.
- Published
- 2024
- Full Text
- View/download PDF
12. Intrahepatic cystic mass and bile duct malformation
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Arianna Pontrelli, Piercarmine Panzera, Francesco Paolo Prete, Enrico Fischetti, Carlotta Testini, and Mario Testini
- Subjects
Biliary tract disease ,Choledochal cyst ,Hepatic hydatid cyst ,Vascular abnormalities ,Surgery ,RD1-811 - Published
- 2024
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13. Congenital Biliary Dilatation Diagnosis Based on 3D Morphological Characteristics
- Author
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Beijing Tsinghua Chang Gung Hospital and Jiaqi Dou, Principal Investigator
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- 2023
14. Preliminary Experience with Continuous Submucosal Anastomosis in Small-Diameter Hepaticojejunostomy during Single-Port Laparoscopic Choledochal Cyst Surgery in Children.
- Author
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Tang, Yingming, Zhang, Jie, Luo, Miao, Li, Fei, Huang, Huang, Zhou, Zhou, Fan, Xia, Qin, Zhijie, He, Guoqing, and Zhuang, Yize
- Subjects
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INTRAHEPATIC bile ducts , *PEDIATRIC surgery , *SURGICAL complications , *BILE ducts , *PATIENTS' families - Abstract
Purpose Hepaticojejunostomy anastomosis (HJA) is the most challenging aspect in single-port laparoscopic choledochal cystectomy and Roux-en-Y hepaticojejunostomy (SPCH) in children, especially in small-diameter anastomoses (diameters less than 5 mm), which are more susceptible to anastomotic stricture. We developed the continuous submucosal technique for HJA (CS-HJA) to lessen postoperative complications. The purpose of this study is to introduce our preliminary experiences with CS-HJA. Methods We retrospectively analyzed all available clinical data of children who underwent SPCH surgery between March 2020 and October 2022. We operated with CS-HJA on 10 children who were diagnosed with small-diameter hepaticojejunostomy (diameter less than 5 mm). Data collection mainly included demographic information, imaging data, perioperative details, and postoperative outcomes. Ten patients were included in this study. The average patient age was 55.2 months; the age range was 3 to 120 months, and the average weight was 11.6 kg; male–female ratio was 1:9. The choledocho had fusiform dilatation in five cases and cystic dilatation in five cases. There was no dilatation of the left and right hepatic ducts or intrahepatic bile ducts in all patients. All patients had no dilatation of the left and right hepatic ducts or intrahepatic bile ducts. All patients underwent a single-port laparoscopic bile-intestinal anastomosis using a submucosal jejunal anastomosis technique. Analysis of the duration of the bile-intestinal anastomosis, the length of the child's stay in the hospital after surgery, the intraoperative complications, and the postoperative complications was performed. Results All the 10 patients underwent successful SPCH by CS-HJA technique. The average length of time for hepaticojejunostomy ranged from 22 to 40 minutes, and the postoperative hospital stay was 5.2 to 9.2 days. There were no instances of bile leakage following the operation. At 17 to 30 months of follow-up, there was no abdominal pain or jaundice, and the reexamination of transaminases, bilirubin, and amylase were normal. Ultrasonography showed no bile duct stricture or dilated bile ducts, and the incision is elegant, and the families of the patients were satisfied. Conclusion In SPCH surgery in children, the CS-HJA technique is safe and feasible for small-diameter hepaticojejunostomy. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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15. Relationships of serum MMP-7 and clinical characteristics in choledochal cyst children
- Author
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Tong Yin, Suyun Chen, Ruijie Zhou, Wei Liu, Mei Diao, and Long Li
- Subjects
MMP-7 ,Choledochal cyst ,Liver fibrosis ,Perforation ,Children. ,Surgery ,RD1-811 - Abstract
Abstract Background Matrix metalloproteinase-7 (MMP-7) is associated with biliary injury. This study aimed to evaluate the relationships of serum MMP-7 with clinical characteristics in choledochal cysts (CDC) children. Methods Between June 2020 and July 2022, we conducted a prospective study of CDCs who underwent one-stage definitive operation at our center. Serum MMP-7 was measured using an enzyme-linked immunosorbent assay. We evaluated the relationships between serum MMP-7 and age, laboratory tests, imaging examinations, liver fibrosis, MMP-7 expression, and perforation. Results A total of 328 CDCs were enrolled in the study, with a median serum MMP-7 of 7.67 ng/mL. Higher serum MMP-7 was correlated with younger age at diagnosis (p
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- 2024
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- View/download PDF
16. Liver Histopathology in Pediatric Patients with Choledochal Cyst
- Author
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Kumar Mayank, Subhasis Roy Choudhury, Smita Singh, and Yogesh Kumar Sarin
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age ,choledochal cyst ,grading ,liver histology ,Pediatrics ,RJ1-570 ,Surgery ,RD1-811 - Abstract
Aim: The aim is to study the various histopathological changes in the liver in pediatric patients with choledochal cyst (CC) and correlate with the presentation and type of cyst. Methods: In a prospective observational study including all pediatric patients who underwent CC excision, histopathological changes of the liver in the form of cholestasis (CHS), portal inflammation (PI), bile duct proliferation (BDP), and fibrosis were studied and graded using a scoring system. They were analyzed in relation to age, sex, symptoms, and type of the cyst. Results: All 30 patients of CC showed various degrees of histopathological changes in the liver in the form of CHS, PI, BDP, and liver fibrosis. Patients 1 years had 17/17 (100%) fusiform variety of CC (P < 0.001). Patients 1 years presented with pain abdomen (P < 0.002). Higher grades of liver fibrosis and BDP were seen in the cystic variety compared to the fusiform variety (P < 0.001). However, no significant association was found with CHS and PI (P > 1.23). Conclusions: Histopathological changes in the liver of varying grades are seen in all patients of CC. Patients of CC
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- 2024
- Full Text
- View/download PDF
17. The timing of minimally invasive surgery for prenatally diagnosed choledochal cysts
- Author
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Shiwen Pan, Wei Li, Huan Chen, and Changgui Lu
- Subjects
Newborn ,Young infant ,Choledochal cyst ,Timing of surgery ,Minimally invasive ,Pediatrics ,RJ1-570 - Abstract
Abstract Objective There are no clear evidence-based recommendations concerning when patients with prenatally diagnosed choledochal cysts (CCs) should undergo surgery. This study was primarily designed to explore the proper timing of minimally invasive surgery for prenatally diagnosed CC patients. Methods Seventy-three patients with prenatally diagnosed CC were enrolled in this study and divided into 4 subgroups according to age at surgery (15 patients in the 3 months group). Eighty-five healthy infants were recruited and divided into 4 age groups (29 in the 3 month group). Preoperative data were collected and compared between CC patients and healthy controls in 4 age groups. Additionally, 73 patients were divided into laparoscopic and open groups to compare postoperative recovery indices and the occurrence of complications to determine the safety and feasibility of laparoscopic CC application in neonates and young infants. Results Twenty-one of 73 (28.8%) patients who were prenatally diagnosed with CCs experienced various clinical symptoms, and 15 of 21 (71.4%) patients experienced clinical symptoms less than 2 months after birth. No differences were found in alanine transaminase (ALT), aspartate transaminase (AST) or aspartate transaminase (APRI) levels between CC patients and controls at ≤ 1 month or 1–2 months of age (all p > 0.05), while higher levels were found in CC patients at 2–3 months or > 3 months of age (all p 2 months of age, while DBIL levels 1 week after surgery were also significantly lower than those before surgery in patients who underwent CC excision at ≤ 2 months of age. The initial oral feeding time in the laparoscopic surgery group was significantly earlier than that in the open surgery group for both CC patients who underwent CC excision at ≤ 2 months of age and those > 2 months of age (all p 2 months of age. Conclusion Most clinical symptoms attributed to CC occur less than 2 months after birth, while liver function and liver fibrosis may deteriorate after 2 months of age in patients with prenatally diagnosed CC. Laparoscopic surgery for CC in newborns and young infants (either less than or more than 2 months old) is safe and feasible and can shorten the initial oral feeding time without increasing complications such as postoperative anastomotic leakage or stricture. Thus, performing laparoscopic CC excisions within 2 months after birth in patients with prenatally diagnosed CC may be appropriate.
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- 2024
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18. Cholangiocarcinoma identified in perforated choledochal cyst in a 3-year-old boy
- Author
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Lun Yu, Wenli Xiu, Aimei Yue, Xiwei Hao, Zhong Jiang, Jie Wu, and Qian Dong
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Choledochal cyst ,Surgery ,Three-dimensional ,Cholangiocarcinoma ,Child ,Pediatrics ,RJ1-570 - Abstract
Abstract Cholangiocarcinoma in patients with Choledochal cysts is rare in childhood; however, it seriously affects the prognosis of the disease. The key to addressing this situation lies in completely removing the extrahepatic cyst. We herein present a case report of a 3-year-old boy with cholangiocarcinoma associated with a choledochal cyst (CDC). Preoperative 3D simulation, based on CT data, played an important role in the treatment of this patient.
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- 2024
- Full Text
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19. Relationships of serum MMP-7 and clinical characteristics in choledochal cyst children.
- Author
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Yin, Tong, Chen, Suyun, Zhou, Ruijie, Liu, Wei, Diao, Mei, and Li, Long
- Subjects
MATRIX metalloproteinases ,ACOUSTIC radiation force impulse imaging ,RECEIVER operating characteristic curves ,HEPATIC fibrosis ,ENZYME-linked immunosorbent assay - Abstract
Background: Matrix metalloproteinase-7 (MMP-7) is associated with biliary injury. This study aimed to evaluate the relationships of serum MMP-7 with clinical characteristics in choledochal cysts (CDC) children. Methods: Between June 2020 and July 2022, we conducted a prospective study of CDCs who underwent one-stage definitive operation at our center. Serum MMP-7 was measured using an enzyme-linked immunosorbent assay. We evaluated the relationships between serum MMP-7 and age, laboratory tests, imaging examinations, liver fibrosis, MMP-7 expression, and perforation. Results: A total of 328 CDCs were enrolled in the study, with a median serum MMP-7 of 7.67 ng/mL. Higher serum MMP-7 was correlated with younger age at diagnosis (p < 0.001), larger cyst sizes (p < 0.001), higher liver fibrosis stages (p < 0.001), and higher incidence of perforation (p < 0.01). Liver MMP-7 was mainly expressed in intrahepatic and extrahepatic biliary epithelial cells. The area under the receiver operating characteristic curve (AUROC) was 0.630 (p < 0.001) for serum MMP-7 in predicting perforation. When serum MMP-7 was combined with γ-glutamyl transferase (GGT), the AUROC increased to 0.706 (p < 0.001). Conclusions: Serum MMP-7 was associated with biliary obstruction in CDCs. Patients with high serum MMP-7 were more likely to have severe liver damage and biliary injury, with higher incidences of liver fibrosis and perforation. [ABSTRACT FROM AUTHOR]
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- 2024
- Full Text
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20. Pancreatic fistula and bleeding following choledochal cyst excision: Experience of two decades.
- Author
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Katakam, Sai Krishna, Sharma, Supriya, Behari, Anu, R., Rahul, Kumar II, Ashok, Singh, Ashish, Singh, Rajneesh, Kumar, Ashok, and Saxena, Rajan
- Subjects
- *
PANCREATIC fistula , *CYSTS (Pathology) , *PANCREATIC surgery , *PANCREATICODUODENECTOMY , *MEDICAL sciences , *HEMORRHAGE , *ABDOMINAL surgery ,BILIARY tract cancer - Published
- 2024
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21. Laparoscopic Hepatic Ductoplasty in Pediatric Choledochal Cyst: What Is the Role, Feasibility, and Outcome?—Systematic Review and Meta-Analysis.
- Author
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Noitumyae, Jarruphong, Amnuaypol, Jarumon, Kiataramkul, Chanokkamol, and Chivapraphanant, Suranetr
- Abstract
Introduction: The pediatric choledochal cyst with hepatic duct stenosis occurs postoperative hepatolithiasis, recurrent cholangitis, or pancreatitis. The laparoscopic hepatic ductoplasty can prevent these incidences. Objectives: To determine the characteristic of hepatic duct stenosis, laparoscopic treatment, and outcomes in systematic review and meta-analysis. Methodology: We searched the published studies on PubMed, Scopus, and Cochrane Library databases from January 1985 to April 2022 in English language. This protocol was registered to PROSPERO (CRD42022332145). Results: Nine published studies and 412 patients were included. The meta-analysis revealed that the locations were the confluence of the left and right hepatic ducts 43.1%, the left or/and the right hepatic duct 8.3%, and the unclassified location 60.4%. These characteristics included a membranous/septum appearance (44.7%) and a circumferential/relative stenosis (22.7%). The laparoscopic techniques were the wide hilar Roux-en-Y hepaticojejunostomy (28.5%), the excision of membranes/septum (26.5%), and the mixed hepatic ductoplasty (45.0%). The outcomes revealed a minor bile leakage of 3.8% and minimal bleeding. The meta-analysis showed no statistical difference between laparoscopic and open techniques in hepatolithiasis (0% versus 2.00%), anastomosis stricture (4.83% versus 10.00%), and no recurrent cholangitis. There was no conversion rate but showed a trend the prolonged operating time in laparoscopy. Conclusion: Laparoscopic hepatic ductoplasty is safe and effective. The characteristics and location can be feasible laparoscopic procedures. So, hepatic ductoplasty decreases hepatolithiasis, anastomosis stricture, or recurrent cholangitis and may increase minor bile leakage. The systematic review registration was PROSPERO system with CRD42022332145. [ABSTRACT FROM AUTHOR]
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- 2024
- Full Text
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22. Liver Histopathology in Pediatric Patients with Choledochal Cyst.
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Mayank, Kumar, Choudhury, Subhasis Roy, Singh, Smita, and Sarin, Yogesh Kumar
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LIVER histology , *CIRRHOSIS of the liver , *SCIENTIFIC observation , *SEX distribution , *JAUNDICE , *ABDOMINAL pain , *CYSTS (Pathology) , *BILE duct abnormalities , *AGE distribution , *HEPATOMEGALY , *DESCRIPTIVE statistics , *CHILDREN'S hospitals , *LONGITUDINAL method , *FIBROSIS , *LIVER , *MICROSCOPY , *CHOLESTASIS - Abstract
Aim: The aim is to study the various histopathological changes in the liver in pediatric patients with choledochal cyst (CC) and correlate with the presentation and type of cyst. Methods: In a prospective observational study including all pediatric patients who underwent CC excision, histopathological changes of the liver in the form of cholestasis (CHS), portal inflammation (PI), bile duct proliferation (BDP), and fibrosis were studied and graded using a scoring system. They were analyzed in relation to age, sex, symptoms, and type of the cyst. Results: All 30 patients of CC showed various degrees of histopathological changes in the liver in the form of CHS, PI, BDP, and liver fibrosis. Patients <1 years had 9/13 (69.2%) cystic variety and those >1 years had 17/17 (100%) fusiform variety of CC (P < 0.001). Patients <1 years frequently presented with jaundice and hepatomegaly and those >1 years presented with pain abdomen (P < 0.002). Higher grades of liver fibrosis and BDP were seen in the cystic variety compared to the fusiform variety (P < 0.001). However, no significant association was found with CHS and PI (P > 1.23). Conclusions: Histopathological changes in the liver of varying grades are seen in all patients of CC. Patients of CC <1 year presented frequently with jaundice, had the cystic type, and had a higher degree of liver damage on histopathology. [ABSTRACT FROM AUTHOR]
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- 2024
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23. The timing of minimally invasive surgery for prenatally diagnosed choledochal cysts.
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Pan, Shiwen, Li, Wei, Chen, Huan, and Lu, Changgui
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MINIMALLY invasive procedures ,NEWBORN infants ,BOTTLE feeding ,HEPATIC fibrosis ,ASPARTATE aminotransferase ,ALANINE aminotransferase - Abstract
Objective: There are no clear evidence-based recommendations concerning when patients with prenatally diagnosed choledochal cysts (CCs) should undergo surgery. This study was primarily designed to explore the proper timing of minimally invasive surgery for prenatally diagnosed CC patients. Methods: Seventy-three patients with prenatally diagnosed CC were enrolled in this study and divided into 4 subgroups according to age at surgery (15 patients in the < 1 month group, 27 in the 1–2 months group, 14 in the 2–3 months group and 17 in the > 3 months group). Eighty-five healthy infants were recruited and divided into 4 age groups (29 in the < 1 month group, 20 in the 1–2 month group, 19 in the 2–3 month group and 17 in the > 3 month group). Preoperative data were collected and compared between CC patients and healthy controls in 4 age groups. Additionally, 73 patients were divided into laparoscopic and open groups to compare postoperative recovery indices and the occurrence of complications to determine the safety and feasibility of laparoscopic CC application in neonates and young infants. Results: Twenty-one of 73 (28.8%) patients who were prenatally diagnosed with CCs experienced various clinical symptoms, and 15 of 21 (71.4%) patients experienced clinical symptoms less than 2 months after birth. No differences were found in alanine transaminase (ALT), aspartate transaminase (AST) or aspartate transaminase (APRI) levels between CC patients and controls at ≤ 1 month or 1–2 months of age (all p > 0.05), while higher levels were found in CC patients at 2–3 months or > 3 months of age (all p < 0.05). ALT, AST and DBIL levels 1 week after surgery were significantly lower than those before surgery in CC patients who underwent laparoscopic CC excision at > 2 months of age, while DBIL levels 1 week after surgery were also significantly lower than those before surgery in patients who underwent CC excision at ≤ 2 months of age. The initial oral feeding time in the laparoscopic surgery group was significantly earlier than that in the open surgery group for both CC patients who underwent CC excision at ≤ 2 months of age and those > 2 months of age (all p < 0.05). No differences were found in the rates of anastomotic leakage or stricture formation between the laparoscopic and open surgery groups at ≤ 2 months or > 2 months of age. Conclusion: Most clinical symptoms attributed to CC occur less than 2 months after birth, while liver function and liver fibrosis may deteriorate after 2 months of age in patients with prenatally diagnosed CC. Laparoscopic surgery for CC in newborns and young infants (either less than or more than 2 months old) is safe and feasible and can shorten the initial oral feeding time without increasing complications such as postoperative anastomotic leakage or stricture. Thus, performing laparoscopic CC excisions within 2 months after birth in patients with prenatally diagnosed CC may be appropriate. [ABSTRACT FROM AUTHOR]
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- 2024
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24. Cholangiocarcinoma identified in perforated choledochal cyst in a 3-year-old boy.
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Yu, Lun, Xiu, Wenli, Yue, Aimei, Hao, Xiwei, Jiang, Zhong, Wu, Jie, and Dong, Qian
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CHOLANGIOCARCINOMA ,CYSTS (Pathology) ,PROGNOSIS - Abstract
Cholangiocarcinoma in patients with Choledochal cysts is rare in childhood; however, it seriously affects the prognosis of the disease. The key to addressing this situation lies in completely removing the extrahepatic cyst. We herein present a case report of a 3-year-old boy with cholangiocarcinoma associated with a choledochal cyst (CDC). Preoperative 3D simulation, based on CT data, played an important role in the treatment of this patient. [ABSTRACT FROM AUTHOR]
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- 2024
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25. Construction of nomogram based on clinical factors for the risk prediction of postoperative complications in children with choledochal cyst
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Yang Lin, Xinru Xu, Shan Chen, Ling Zhang, Jianbin Wang, Xinyi Qiu, and Lizhi Li
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choledochal cyst ,pediatric ,postoperative complications ,nomogram ,logistic regression ,Pediatrics ,RJ1-570 - Abstract
ObjectiveThe aim of the study was to develop a prediction nomogram based on clinical factors to assess the risk of postoperative complications in children with congenital choledochal cyst.MethodsThe clinical data from 131 children who underwent choledochal cyst resection and Roux-en-Y hepaticojejunostomy in our hospital between January 2016 and December 2022 were retrospectively analyzed. The general information, clinical symptoms, procedure, biochemical indicators, and imaging data were recorded. A prolonged hospital stay induced by postoperative complications or a follow-up over 6 months was assessed as the event outcome. A logistics regression analysis was performed to screen for risk factors with statistical significance in inducing postoperative complications. Then, with the dataset split into the training group and internal validation group, the nomogram for the prediction of postoperative complications was developed based on a computer algorithm. In addition, the receiver operating characteristic (ROC) curve and calibration curve were performed for nomogram verification.ResultsOf 131 children, the multivariate logistics regression analysis suggested that age ≤2 years [odds ratio (OR) 0.93; 95% confidence interval (CI) 0.15–5.65; p = 0.938], Todani classification type 1 (OR 36.58; 95% CI 4.14–871.74; p = 0.005), cyst wall thickness >0.4 cm (OR 10.82; 95% CI 2.88–49.13; p
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- 2024
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26. Type I choledochal cyst. Total laparoscopic resection and Roux-en-Y reconstruction to two separated ducts.
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Reyes, Natalia, Sotomayor, Camila, Inzunza, Martín, Briceño, Eduardo, Viñuela, Eduardo, Martínez, Jorge, and Jarufe, Nicolás
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CYST rupture , *GASTRIC bypass , *LAPAROSCOPIC surgery , *BILE ducts , *OPERATIVE surgery - Abstract
A choledochal cyst is a rare condition that requires surgical treatment to prevent complications, such as obstructive jaundice, cyst rupture, cholangitis, and the risk of malignancy. Complete cyst excision is considered the best option, as it reduces the risk of inflammation and the development of cholangiocarcinoma. Therefore, cholecystectomy and complete cyst resection followed by reconstruction with a Roux-en-Y hepaticojejunostomy is the treatment of choice. We present a case (with video) that shows the complete resection of a type I choledochal cyst with Roux-en-Y reconstruction of two separate ducts since the right posterior duct reached the cyst independently. The laparoscopic approach offers all the advantages of mini-invasive surgery and better visualization of the structures; however, biliary reconstruction to fine ducts implies a surgical challenge that requires high training in mini-invasive surgery. [ABSTRACT FROM AUTHOR]
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- 2024
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27. Outcome of biliary-enteric reconstruction with hepaticoduodenostomy following choledochal cyst resection: A prospective study
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Ashok Kumar Goyal, Rahul Gupta, and Neelam Meena
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biliary-enteric reconstruction ,choledochal cyst ,complications ,good outcome ,hepaticoduodenostomy ,meta-analysis ,Pediatrics ,RJ1-570 ,Surgery ,RD1-811 - Abstract
Background: The two most commonly performed methods of biliary-enteric reconstruction following choledochal cyst resection are Roux-en-Y hepaticojejunostomy (HJ) and hepaticoduodenostomy (HD). There is a lack of consensus regarding the better technique between them. This study aimed to evaluate the outcomes, efficacy and early complications of HD as a mode of biliary reconstruction after surgical resection of a choledochal cyst. Materials and Methods: This was a multi-institutional prospective study carried out in high-volume tertiary care teaching institutes from January 2010 to December 2022. All children managed with HD following choledochal cyst resection were analysed for their early complications and outcomes. Results: A total of 74 patients were included in this study. There were 59 (79.73%) females and 15 (20.27%) males. Thirty-nine (52.70%) patients had jaundice at the time of presentation. Magnetic resonance cholangiopancreatography was performed in 57 (77.03%) patients following ultrasonography. Intraoperatively, malrotation was present in 2 (2.70%) patients. In our study, operating time ranged from 60 to 195 min (mean: 118 min). Hospital stays ranged from 8 to 17 days (mean: 11.5 days). The post-operative biliary leak was seen in 7 (9.50%) patients, out of which 6 (8.11%) minor leaks were managed conservatively. Roux-en-Y HJ was performed on 1 (1.35%) patient with a major leak. In our series, 4 (5.40%) patients developed cholangitis; post-operative haemorrhagic nasogastric aspirate 5 (6.76%), post-operative pancreatitis 3 (4.05%) and wound infection 4 (5.40%) were observed and managed conservatively. None of the patients in our study developed an anastomotic stricture, bile gastritis and adhesive small bowel obstruction. Conclusion: Resection of choledochal cyst with HD reconstruction is safe and feasible with short operative time. HD is a viable option for operative management of choledochal cyst with low complication rates and faster recovery.
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- 2024
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28. Dynamic Hepatocholescintigraphy with Bromesida® 99mTc
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S. P. Mironov and V. B. Sergienko
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hepatocholescintigraphy ,bromesida 99mtc ,mebrofenin ,choledochal cyst ,cholecystitis ,duodenogastric reflux ,gallbladder dyskinesia ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Hepatobiliary scintigraphy using radiopharmaceuticals (RPh) labeled with short-lived technetium‑99m (99mТс) has been used since the mid‑1970s and still retains its diagnostic value. The lecture focuses on key aspects of the pharmacokinetics of lidocaine analogs based on N-substitutions of iminodiacetic acid. The methodology and diagnostic significance of hepatocholescintigraphy with Bromesida® 99mTс (mebrofenin), including computer registration of RPh passage, anatomical and functional characteristics of liver, bile ducts, gallbladder and duodenum, are considered. Scintigraphic semiotics in choledochal cysts, acute and chronic cholecystitis, gallbladder and duodenum dyskinesia, are discussed. The presented clinical case illustrates the possibilities of Bromesida® 99mTс scintigraphy in the gallbladder form anomaly.
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- 2024
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29. The Initial Experience of Laparoscopic Management for Type VI Choledochal Cyst in Children.
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Li, Bing, Chen, Bing Wei, and Xia, Lin Shun
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Purposes: Dilatation of cystic duct is very rare and had been classified as Todani type VI choledochal cyst. Choledochal cyst combined with dilatation of cystic duct is difficult to diagnose preoperatively. The purpose of this study is to report the rare variants and discuss the significance and laparoscopic management strategy in children. Methods: The subjects for this study were 10 consecutive patients with type VI choledochal cyst who had laparoscopic procedures at our institute between January 2009 and January 2023. Laparoscopic cholecystectomy, excision of the dilated cystic duct, and choledochal cyst were carried out, and the continuity of the biliary duct was re-established through a Roux-en-Y hepaticojejunostomy. Results: Cystic duct combined with the common bile duct dilatation was revealed in all the patients intraoperatively. Laparoscopic procedures were completed with no conversions. The postoperative recovery was uneventful. The mean follow-up duration was 27 ± 12.7 months (range 5–36 months) with no postoperative complications encountered. Conclusions: The rare entity of type VI choledochal cyst should be recognized as a distinct type of choledochal cyst and need to be given enough attention clinically. The laparoscopic procedure is a feasible option for experienced surgeons. [ABSTRACT FROM AUTHOR]
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- 2024
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30. Surgical Strategies for Neonates with Prenatally Diagnosed Congenital Biliary Dilatation.
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Shirota, Chiyoe, Hinoki, Akinari, Tainaka, Takahisa, Sumida, Wataru, Makita, Satoshi, Amano, Hizuru, Takimoto, Aitaro, Yasui, Akihiro, Nakagawa, Yoichi, Liu, Jiahui, Guo, Yaohui, Kato, Daiki, Goda, Yousuke, Maeda, Takuya, and Uchida, Hiroo
- Abstract
This study aimed to develop a postnatal treatment strategy for infants with prenatally diagnosed congenital biliary dilatation. We performed a retrospective study of patients with prenatal diagnosed congenital biliary dilatation (CBD), aged <1 year who underwent surgery at our hospital between 2013 and 2023. We classified the patients into two groups, the "early group," consisting of patients who could not wait for growth, and required early surgery, and the "scheduled group," consisting of patients who were asymptomatic and could undergo scheduled surgery, and compared them. The parameters for early surgical prediction were AST, ALT, TB, DB, and CRP levels at birth, 1 week, 2 weeks, 1 month, 2 months, and 3 months after birth, and immediately before surgery, as well as the cyst diameter, presence of intrahepatic bile duct dilation, and presence of debris in the common bile duct. During the study period, 15 patients were diagnosed prenatally. The cyst diameter was significantly larger at all points in the early group. Patients with a cyst diameter of >30 mm at birth, intrahepatic bile duct dilatation at birth, and postnatal enlargement of the common bile duct to >30 mm are more likely to develop symptoms early. Blood biochemistry tests showed no significant differences between the two groups. Patients with a cyst diameter >30 mm in the early postnatal period require careful postnatal management and parents should be counseled regarding the high likelihood of their child needing surgery within the first 3 months of life. Level IV. • The postnatal cyst diameter is the key to the treatment strategy for prenatally diagnosed choledochal cysts. • Infants with cyst diameters greater than 30 mm require early surgery. • Neonatal Choledochal cysts with cyst diameters greater than 30 mm require careful management. [ABSTRACT FROM AUTHOR]
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- 2024
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31. Does Congenital Biliary Dilatation Todani Type II (Diverticular Type) Really Exist?
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Saito, Takeshi, Ando, Hisami, Ishihara, Shin, Itoi, Takao, Urushihara, Naoto, Otsuka, Masayuki, Koshinaga, Tsugumichi, Nagakawa, Yuichi, Hamada, Yoshinori, and Morotomi, Yoshiki
- Abstract
The aim of the study is to clarify the clinicopathological and biliary morphological characteristics in reported cases of diverticular congenital biliary dilatation (CBD). Using PubMed and the Japan Medical Abstracts Society, articles on possible diverticular CBD were extracted and the clinical pictures examined. We also sought evidence for definitions of diverticular CBD and the associated condition of pancreaticobiliary maljunction (PBM) using the original articles by Alonso-Lej and Todani. The characteristic biliary morphologies of cases with images were also investigated. Analyses of 211 possible cases superficially demonstrated multiple diverticula in 12 (12%) and single diverticulum in 89 (88%), with diverticula located in the upper (n = 38, 38%), middle (n = 32, 32%), or lower (n = 26, 26%) biliary tract in and presence of intra-diverticular stones, PBM, and biliary carcinoma in 23% (n = 18), 39% (n = 25), and 11% (n = 14), respectively. However, evidence defining diverticular CBD or justifying the lack of associated PBM was not demonstrated even in the original articles. Scrutiny of the biliary anatomy in 59 cases with images showed incorrect inclusions of types I or IV-A with an irregular biliary duct wall or dilated cystic duct, periampullary choledochal diverticula, or even solitary biliary cysts. Authentic diverticular CBD, representing the diverticulum connected to the middle of the common bile duct via a thin, patent stalk was seen in only 6 cases. Real diverticular CBD appears extremely rare. The lack of an objective definition allows wide interpretations of clinical pictures, creating inconsistencies in the diagnosis and treatment of CBD and raising questions regarding the utility of conventional classifications. Level III. • Diverticular CBD is included in the classic Alonso-Lej and Todani classifications of congenital biliary dilatation (CBD) as a Type 2 cyst. • Scrutiny of previous publications on potential diverticulae of the common bile duct showed a lack of evidence for this type suggesting extreme rarity, and rather overdiagnosis and erroneous inclusion of various biliary morphologies. • The inclusion of this diverticular type in conventional classifications of congenital biliary dilatation has created uncertainties and inconsistency and should probably be removed. [ABSTRACT FROM AUTHOR]
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- 2024
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32. Characteristics and malignancy rates of adult patients diagnosed with choledochal cyst in the West: a systematic review.
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Bloomfield, Grace C., Nigam, Aradhya, Calvo, Inochi Gonzalez, Dorris, C. Scott, Fishbein, Thomas M., Radkani, Pejman, and Winslow, Emily R.
- Abstract
The approach to patients with choledochal cysts (CCs) remains varied and subject to institutional practices. Owing to the rarity of the disease, the optimal treatment remains poorly defined, particularly in the adult population. This study aimed to review the literature on adult patients with CCs to evaluate trends of diagnosis and management in Western countries. A literature search of 3 electronic databases was performed on adult patients diagnosed with CCs in Western institutions. A review of published literature was completed with comprehensive screening by 2 independent reviewers. Studies were analyzed, and data on surgical approach, malignancies, and follow-up were collected. Findings are presented in concordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. Of the 3488 articles retrieved, 21 studies evaluated Western adults with CCs for a combined population of 1337 patients. The most common Todani subtypes included types I (64%) and IV (22%). Symptoms at presentation included abdominal pain and jaundice, although many were asymptomatic. Ultrasound was used most frequently for diagnosis, followed by computed tomography and endoscopic cholangiopancreatography. The combined malignancy rate was 10.9%, with cholangiocarcinoma being the most prevalent. Complete extrahepatic cyst resection was standard for type I and IV CCs. Among malignancies, 18.5% and 16.4% were observed in patients with prior resection and internal drainage, respectively. A significant proportion of patients who undergo resection of CC disease harbor malignancy. Cancer risk seems reduced but not eliminated with complete resection, which remains the standard treatment. Additional studies are needed to standardize guidelines for the diagnosis and postoperative care of patients in Western countries. [ABSTRACT FROM AUTHOR]
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- 2024
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33. Outcomes of continous versus interrupted suturing techniques for biliary-enteric anastomosis after choledochal cyst excision in children.
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Sabra, Tarek Abdelazeem, Abdelmohsen, Sarah Magdy, Maher, Ahmed, Abdelgawaad, Moamen Shalkamy, Mohamed, Abdelhalem Showkat, Mohammed, Haitham Mohammed Ahmad, and Badawy, Amr
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SUTURING , *CHILD patients , *CONTINUOUS groups , *CYSTS (Pathology) , *SUTURES - Abstract
In this study, the biliary-enteric anastomosis following choledochal cyst excision was studied using continuous suture and interrupted suture procedures in a pediatric population. Patients and methods In this study, information on 57 children who received continuous suture choledochal cyst surgery at our facility between 2015 and 2020 was gathered retrospectively. The patients that were enrolled were divided into two groups: continuous suture (n=24) and interrupted suture (n=33). Anastomotic leakage, anastomotic duration in minutes, hospital stay in days, and cost were all compared between these groups. Results The incidence of anastomotic leakage was higher in the interrupted suture group (4.17 vs. 6.6% for continuous suture and interrupted suture, respectively), but the difference was statistically insignificant (P=0.63). The groups did not differ regarding hospital stays (P=0.25). The mean time required to complete the anastomosis in the continuous suture group was 15.3±4.1 min, compared with 23.5±5.2 min in the interrupted suture group (P<0.0001). The costs were €5 ±0.0 in the continuous suture group and €30±6.4 in the interrupted suture group (P<0.0001). Conclusion The anastomotic leakage and hospital stay did not differ between the continuous suture and interrupted suture groups. In contrast, the continuous suture group had a considerable advantage over the interrupted suture group in terms of anastomotic duration and cost. [ABSTRACT FROM AUTHOR]
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- 2024
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34. Outcome of Biliary‑enteric Reconstruction with Hepaticoduodenostomy Following Choledochal Cyst Resection: A Prospective Study.
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Goyal, Ashok Kumar, Gupta, Rahul, and Meena, Neelam
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ENDOSCOPIC retrograde cholangiopancreatography , *CYSTS (Pathology) , *LONGITUDINAL method , *BOWEL obstructions , *SMALL intestine , *MAGNETIC resonance - Abstract
Background: The two most commonly performed methods of biliary-enteric reconstruction following choledochal cyst resection are Roux-en-Y hepaticojejunostomy (HJ) and hepaticoduodenostomy (HD). There is a lack of consensus regarding the better technique between them. This study aimed to evaluate the outcomes, efficacy and early complications of HD as a mode of biliary reconstruction after surgical resection of a choledochal cyst. Materials and Methods: This was a multi-institutional prospective study carried out in high-volume tertiary care teaching institutes from January 2010 to December 2022. All children managed with HD following choledochal cyst resection were analysed for their early complications and outcomes. Results: A total of 74 patients were included in this study. There were 59 (79.73%) females and 15 (20.27%) males. Thirty‑nine (52.70%) patients had jaundice at the time of presentation. Magnetic resonance cholangiopancreatography was performed in 57 (77.03%) patients following ultrasonography. Intraoperatively, malrotation was present in 2 (2.70%) patients. In our study, operating time ranged from 60 to 195 min (mean: 118 min). Hospital stays ranged from 8 to 17 days (mean: 11.5 days). The post-operative biliary leak was seen in 7 (9.50%) patients, out of which 6 (8.11%) minor leaks were managed conservatively. Roux‑en‑Y HJ was performed on 1 (1.35%) patient with a major leak. In our series, 4 (5.40%) patients developed cholangitis; post‑operative haemorrhagic nasogastric aspirate 5 (6.76%), post‑operative pancreatitis 3 (4.05%) and wound infection 4 (5.40%) were observed and managed conservatively. None of the patients in our study developed an anastomotic stricture, bile gastritis and adhesive small bowel obstruction. Conclusion: Resection of choledochal cyst with HD reconstruction is safe and feasible with short operative time. HD is a viable option for operative management of choledochal cyst with low complication rates and faster recovery. [ABSTRACT FROM AUTHOR]
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- 2024
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35. Histopathological Study and Expression of Beta-Catenin in Congenital Choledochal Cyst in a Tertiary Care Pediatric Referral Center in South India.
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Philpose, Rashmi Tresa, Mohammed, Abdul Aleem, and Gowni, Ashrith Reddy
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PEDIATRIC therapy , *CYSTS (Pathology) , *HISTOPATHOLOGY , *TERTIARY care , *BILE ducts - Abstract
Purpose: Choledochal cysts are congenital anomalies that occur as localized cystic or fusiform dilatations of the biliary tree. Reflux and stasis of pancreatic enzymes in the biliary duct may relate to the development of intestinal metaplasia which might be an important factor related to the carcinogenesis of choledochal cyst, thus the expression of beta-catenin in the metaplastic epithelium might be associated with malignant transformation of choledochal cyst epithelium. Methods: This study was conducted at a tertiary care pediatric center between October 2014 and March 2017. Forty patients were evaluated for epithelial lining, mural ulceration, fibrosis, inflammation, and metaplasia. Results: Out of 40, 12 cases (30.0%) were the infantile age group and 28 cases (70.0%) were in the classic pediatric group. Ulceration was classified as grade 0 (14 cases, 35.0%), grade 1 (17 cases, 42.5%), or grade 2 (nine cases, 22.5%). Inflammation was classified as grade 0 (2 cases, 5.0%), grade 1 (26 cases, 65.0%), or grade 2 (12 cases, 30.0%). Fibrosis was classified as grade 0 (five cases, 12.5%), grade 1 (11 cases, 27.5%), grade 2 (17 cases, 42.5%), or grade 3 (seven cases, 17.5%). Metaplasia was noted in five (12.5%) out of 40 cases. All choledochal cysts with metaplasia showed beta-catenin nuclear positivity on immunohistochemistry and were followed up. Conclusion: This study emphasizes the importance of detailed histopathological examination and documentation of metaplastic changes. Metaplasia was associated with beta-catenin nuclear positivity. These findings suggest a potential role for beta-catenin as a marker of metaplastic changes in choledochal cysts. [ABSTRACT FROM AUTHOR]
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- 2024
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36. Comparison of Surgical Outcomes of Laparoscopic and Robotic Surgery in Adult Choledochal Cysts.
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Han, Janghun, Lee, Jae Hoon, Park, Yejong, Kwak, Bong Jun, Song, Ki Byung, Lee, Woohyung, Hwang, Dae Wook, and Kim, Song Cheol
- Abstract
Background: Minimally invasive surgery (MIS) for cyst excision and Roux-en-Y hepaticojejunostomy (HJ) is widely performed for adult choledochal cysts. Few articles compared the robotic and laparoscopic approaches for choledochal cysts. Methods: Between 2014 and 2022, 157 patients who underwent MIS for choledochal cysts were retrospectively analyzed. Perioperative outcomes of patients who underwent totally robotic surgery, robot-assisted surgery, and laparoscopic surgery were compared, respectively. Also, postoperative outcomes of patients with robotic reconstruction and laparoscopic reconstruction during HJ were compared. Results: Perioperative outcomes were comparable between robotic and laparoscopic groups. The suturing technique for the anterior and posterior walls of the HJ differed significantly between the robotic and laparoscopic reconstruction groups (P = .001). However, there were no significant differences in postoperative outcomes, including total complications (P = .304), major complications (P = .411), and postoperative interventions (P = .411), between the two groups. Conclusions: The robotic and laparoscopic approaches for adult choledochal cysts have comparable surgical outcomes. In the MIS era, robotic surgery could be an alternative surgical option for adult choledochal cysts. [ABSTRACT FROM AUTHOR]
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- 2024
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37. A trans-umbilical single-site plus one robotic-assisted surgery for choledochal cyst resection in children
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Yucan Lin, Shan Chen, Yang Lin, Ling Zhang, Jianbin Wang, Xinyi Qiu, Di Xu, and Lizhi Li
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trans-umbilical single-site plus one ,robotic-assisted ,laparoscopy ,choledochal cyst ,children ,Pediatrics ,RJ1-570 - Abstract
ObjectiveThe purpose of this study is to compare the intraoperative and postoperative outcomes of a trans-umbilical single-site plus one robot-assisted surgery and a trans-umbilical single-site laparoscopic surgery in the treatment of choledochal cysts.MethodsWe retrospectively analyzed clinical data from 49 children diagnosed with choledochal cysts who were admitted to our hospital between June 2020 and December 2023. Among these patients, 24 underwent a trans-umbilical single-site plus one Da Vinci robot-assisted surgery (the robot group) and 25 underwent a trans-umbilical single-site laparoscopic-assisted surgery (the laparoscopic group). We compared differences in intraoperative and postoperative outcomes between the two groups.ResultsThere was no significant difference between the two groups of patients in terms of gender, age, weight, clinical symptoms, maximum cyst diameter, type, postoperative complications, and facial expression, leg movement, activity, crying, and comfortability (FLACC) scoring (p > 0.05). Compared with the patients in the laparoscopic group, those in the robot group had less intraoperative bleeding [10 (8–12) vs. 15 (11.5–18) ml, p
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- 2024
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38. Choledochal Cyst with Pancreas Divisum – Surgical Insight into A Rare Associatio
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Payal Kaw, Anu Behari, and Supriya Sharma
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Choledochal cyst ,Pancreas divisum ,Fistula ,Medicine - Abstract
Congenital pancreaticobiliary anomalies like pancreatic divisum (PD), choledochal cysts (CDC), anomalous pancreaticobiliary ductal union (APBDU) have been reported in 5.7% of patients undergoing magnetic resonance cholangiopancreatography. CDC’s are characterized by abnormal dilatations of the intrahepatic and/or extrahepatic portion of the biliary tree and can be complicated by cystolithiasis, cholangitis, pancreatitis and malignant transformation necessitating surgical managemnet. While CDCs are commonly associated with APBDU, combination of CDC with PD is rare and a potential surgical challenge. We report a case of recurrent cholangitis in a patient with CDC and coincidental classic PD and illustrate how preoperative identification, fastidious dissection technique to safeguard both the pancreatic ducts and simple intraoperative preemptive strategies may decrease consequences of distal stump blowout.
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- 2024
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39. A RCT Study of ERAS in Infants With Choledochal Cyst
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Weibing Tang, professor
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- 2023
40. Robotic versus laparoscopic surgery for choledochal cyst in children with aberrant hepatic ducts: A retrospective study
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Xiaolong Xie, Kewei Li, and Bo Xiang
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Choledochal cyst ,Aberrant hepatic duct ,Laparoscopic surgery ,Robotic surgery ,Children ,Surgery ,RD1-811 - Abstract
Background: The aim of this current study was to compare the safety and effectiveness between robotic and laparoscopic surgery in pediatric patients suffered from choledochal cysts associated with aberrant hepatic duct. Methods: Patients suffered from choledochal cysts associated with aberrant hepatic duct who were treated with laparoscopic or robotic procedures between January 2009 and June 2022 were retrospectively analyzed. The patients were divided into laparoscopic and robotic group according to different surgical methods. The data collected included the demographic information, imaging information, operative details and postoperative complications. Results: Twenty-two patients were included in the analysis consisting of 14 cases in laparoscopic group and 8 cases in robotic group. The male to female ratio was 1:6.33. The median age of the patients was 40.00 months with a mean weight of 16.99 kg. There were no significant differences in patient characteristics between the two groups. The operation and anesthesia time were significantly longer in the laparoscopic procedures group (238.14 ± 17.24 min, 265.93 ± 19.51 min, respectively) than robotic procedures group (208.00 ± 9.24 min, 230.13 ± 12.87 min, respectively) (p
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- 2023
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41. Robotic surgery for congenital biliary dilatation using the scope switch technique (with video)
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Kosei Takagi, Yuzo Umeda, Ryuichi Yoshida, Tomokazu Fuji, Kazuya Yasui, Takahito Yagi, and Toshiyoshi Fujiwara
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Choledochal cyst ,Congenital biliary dilatation ,Robot ,Surgical approach ,Surgery ,RD1-811 - Abstract
Technique: Minimally invasive congenital biliary dilatation (CBD) surgery is technically demanding. However, few studies have reported surgical approaches of robotic surgery for CBD. This report presents robotic CBD surgery using a scope-switch technique. Our robotic surgery technique for CBD consisted of four steps: step 1, Kocher's maneuver; step 2, dissection of the hepatoduodenal ligament using the scope switch technique; step 3, preparation for the Roux-en-Y loop; and step 4, hepaticojejunostomy. Results: The scope switch technique can provide different surgical approaches for dissecting the bile duct, including anterior approach by the standard position and right approach by the scope switch position. When approaching the ventral and left side of the bile duct, anterior approach with the standard position is suitable. In contrast, the lateral view by the scope switch position is preferable for approaching the bile duct laterally and dorsally. Using this technique, the dilated bile duct can be dissected circumferentially from four directions: anterior, medial, lateral, and posterior. Thereafter, complete resection of the choledochal cyst can be achieved. Conclusions: The scope switch technique in robotic surgery for CBD can be useful for dissecting around the bile duct with different surgical views, leading to the complete resection of the choledochal cyst.
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- 2023
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42. Timing of Operation in Children With a Prenatal Diagnosis of Choledochal Cyst (CDCPS)
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Xisi Guan, Clinical attending doctor
- Published
- 2022
43. Key postnatal magnetic resonance characteristics for differentiating cystic biliary atresia from choledochal cyst
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He, Fan, Guan, Xisi, Yang, Boyang, and Liu, Hongsheng
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- 2024
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44. Analysis of the Incidence of Cholangiocarcinoma on Choledochal Cyst in a Western Center (QuiCo)
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María Teresa Moreno Asencio, MorenoAsencioM
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- 2022
45. A new variant of Choledochal cyst-type VI: a rare case presentation and review of the literature.
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Bai, Yufan, Li, Chunmei, Tang, Jihong, and He, Min
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LITERATURE reviews , *BILE ducts , *HOSPITAL admission & discharge , *GALLBLADDER cancer , *DUODENAL diseases , *GALLBLADDER , *HEALTH care teams - Abstract
A 53-year-old male patient with a previous diagnosis of dilatation of the common bile duct was admitted to the hospital due to recurrent episodes of vague epigastric pain over a 4-month period. After undergoing abdominal CT, MRI, MRCP, ERCP examinations, together with joint diagnosis by the radiology department and the gastroscopy unit, the diagnosis of a cystic dilatation of the common bile duct was excluded, and to preliminarily diagnose as cystic lesion at the hepatoduodenum ligament. A nasobiliary tube was preset before the surgery, and it was found that the gallbladder, the cyst, and the common bile duct were connected in sequence during the surgery, leading to the definitive diagnosis of biliary cyst of the cystic duct. During the surgery, the anatomical position of the common bile duct was accurately identified, avoiding iatrogenic biliary injury and preserving the integrity of the common bile duct structure. The patient recovered and was discharged from the hospital on the 14th postoperative day. Cystic duct cysts are a relatively new and rare condition. This case demonstrates that clinical decision-making by a multidisciplinary team is of great significance for such diseases, and preoperative assessment of the anatomical relationship between cystic dilation lesions in the hepatic portal region and the biliary system and gallbladder is also crucial. [ABSTRACT FROM AUTHOR]
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- 2023
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46. Prospective evaluation of common hepatic duct histopathology at the time of choledochal cyst excision ranging from children to adults.
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Nikai, Koki, Koga, Hiroyuki, Suda, Kazuto, Miyahara, Katsumi, Lane, Geoffrey J., Arakawa, Atsushi, Fukumura, Yuki, Saiura, Akio, Hayashi, Yutaka, Nagakawa, Yuichi, Okazaki, Tadaharu, Takishita, Chie, Yanai, Toshihiro, and Yamataka, Atsuyuki
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STAINS & staining (Microscopy) , *HISTOPATHOLOGY , *CYSTS (Pathology) , *HEMATOXYLIN & eosin staining , *INVERSE relationships (Mathematics) - Abstract
Purpose: To evaluate common hepatic duct just distal to the HE anastomosis (d-CHD) prospectively for mucosal damage, inflammation, fibrosis, dysplasia, carcinoma in situ, malignant transformation, effects of serum amylase, and symptoms at presentation in CC cases ranging from children to adults. Methods: Cross-sections of d-CHD obtained at cyst excision 2018–2023 from 65 CC patients; 40 children (< 15 years old), 25 adults (≥ 15) were examined with hematoxylin and eosin, Ki-67, S100P, IMP3, p53, and Masson's trichrome to determine an inflammation score (IS), fibrosis score (FS), and damaged mucosa rate (DMR; damaged mucosa expressed as a percentage of the internal circumference). Results: Mean age at cyst excision ("age") was 18.2 years (range: 3 months-74 years). Significant inverse correlations were found for age and DMR (p = 0.002), age and IS (p = 0.011), and age and Ki-67 (p = 0.01). FS did not correlate with age (p = 0.32) despite significantly increased IS in children. Dysplasia was identified in a 4-month-old girl with cystic CC. Serum amylase was elevated in high DMR subjects. Conclusions: High DMR, high IS, and evidence of dysplasia in pediatric CC suggest children are at risk for serious sequelae best managed by precise histopathology, protocolized follow-up, and awareness that premalignant histopathology can arise in infancy. [ABSTRACT FROM AUTHOR]
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- 2023
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47. Premalignant/malignant histology in excised choledochal cyst specimens from children. Experience and literature review.
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Okazaki, Tadaharu, Nikai, Koki, Koga, Hiroyuki, Miyano, Go, Ochi, Takanori, Lane, Geoffrey J., Fukumura, Yuki, and Yamataka, Atsuyuki
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LITERATURE reviews , *CYSTS (Pathology) , *HISTOLOGY , *DYSPLASIA , *JEJUNOSTOMY - Abstract
Background: Dysplasia, carcinoma in situ, and other malignant transformation or premalignant/malignant histopathology (PMMH) seem uncommon in pediatric choledochal cyst (CC). A literature review and the authors' experience are presented. Methods: All reports about PMMH in CC patients 15 years old or younger published in English and all cases of PMMH in specimens excised from CC patients 15 years old or younger by the authors were reviewed. Results: Of 20 published reports, PMMH was adenocarcinoma (n = 4), sarcoma (n = 4), and dysplasia (n = 12). Treatment for malignancies was primary pancreaticoduodenectomy (PD; n = 2) or cyst excision/hepaticojejunostomy (Ex/HJ; n = 6). Outcomes at the time of writing for malignancies: 2 deaths, 4 survivors after follow-up of 2 years, and 2 lost to follow-up. No dysplasia case has undergone malignant transformation. The authors have experienced 7 cases of PMMH; adenocarcinoma in situ (AIS; n = 1) and dysplasia (n = 6). Conclusions: The present study identified the youngest cases of AIS and dysplasia from specimens excised when they were 3 years old and 4 months old, respectively. Both are published for the first time as evidence that PMMH can complicate CC in young patients. Long-term protocolized postoperative follow-up is mandatory when PMMH is diagnosed in pediatric CC. [ABSTRACT FROM AUTHOR]
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- 2023
- Full Text
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48. Comparison of robotic assistance and laparoscopy for pediatric choledochal cyst: advantages of robotic assistance.
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Yamada, Shunsuke, Koga, Hiroyuki, Seo, Shogo, Ochi, Takanori, Shibuya, Souichi, Yazaki, Yuta, Takeda, Masahiro, Fujiwara, Naho, Lane, Geoffrey J., and Yamataka, Atsuyuki
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CYSTS (Pathology) , *PEDIATRIC surgery , *SURGICAL complications , *LAPAROSCOPY , *PANCREATIC fistula - Abstract
Aim: Surgery for pediatric choledochal cyst (CC), complete excision (CE), and Roux-en-Y hepaticojejunostomy anastomosis (HJA) can be performed using laparoscopy (Lap), robotic-assistance (Rob; da Vinci Xi/Si), or both (Lap/Rob). Methods: Lap was used exclusively between 2009 and 2021 (n = 31) and Rob was introduced in 2017 (n = 23). All subjects were matched for age, weight, BMI, and episodes of preoperative pancreatitis. For Rob, the first 15/23 were Lap-CE/Rob-HJA and the last 8/23 were Rob-CE/Rob-HJA. Results: Total anastomotic time (TAT), TAT per suture during HJA, and time taken for dissection during CE were significantly shorter with less variance for Rob, although overall operative times were similar. Serum amylase on postoperative days 3, 5, and 7 were significantly higher for Lap. Times taken to ambulate, for return of bowel sounds, and discharge home were all significantly shorter for Rob. All postoperative complications occurred after Lap; HJA leak (n = 1; 3.2%), HJA stricture (n = 1; 3.2%), both treated by open re-HJA; and pancreatic fistula (n = 6; 19%), all treated conservatively. Conclusion: Dissection and recovery were faster with Rob while overcoming Lap-associated shortcomings to prevent complications associated with suturing. Both CE and HJA were safer and more reliable with Rob, a reflection of Rob's superiority. [ABSTRACT FROM AUTHOR]
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- 2023
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49. CORRELATION BETWEEN ULTRASONOGRAPHY AND MAGNETIC RESONANCE CHOLANGIOPANCREATOGRAPHY IN VARIOUS TYPES OF CHOLEDOCHAL CYSTS.
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Reddy, Yeruva Yeshwanth, Kavya, Are, Bharath Reddy, Kikkuru Jaya, and Murmu, Jimut Bahan
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MAGNETIC resonance , *ULTRASONIC imaging , *CYSTS (Pathology) , *DIAGNOSTIC ultrasonic imaging , *MEDICAL schools - Abstract
Background and objectives: To assess and compare the results of magnetic resonance cholangiopancreatography and ultrasonography in the diagnosis of various kinds of choledochal cysts. To investigate the efficacy of magnetic resonance cholangiopancreatography and ultrasonography as the primary diagnostic methods for patients who exhibit Choledochal Cyst clinical characteristics. To evaluate the limitations of magnetic resonance cholangiopancreatography and ultrasonography in the diagnosis of various forms of choledochal cysts. Method: The study was a hospital-based cross-sectional study that included thirty patients who were referred for Ultrasonography and Magnetic Resonance Cholangiopancreatography to the Department of Radiodiagnosis, Nilratan Sircar Medical College & Hospital, Kolkata, West Bengal, India, with a clinical suspicion of Choledochal Cysts lesions and unintentionally discovered Choledochal Cysts lesions on patient's Ultrasonography and Magnetic Resonance Cholangiopancreatography done for other reasons during study period between January 2019 to June 2020. Result: The association between the cyst type in various radiological scans was not statistically significant (p=0.9455). Fusiform cysts were present in 29 (96.7%) individuals who underwent USG scanning, while saccular cysts were found in 1 (3.%) patients. The relationship between the CBD cyst's shape and the various radiological scans was not statistically significant (p=0.3132). In both MRCP and USG scans, all CBD cysts were fusiform. Shape of the CBD cyst did not significantly differ between USG and MRCP scanning (p=1.0000). During MRCP scanning, 29 patients (96.7%) exhibited fusiform cysts, while one patient (3.3 %) had saccular cysts. Conclusion: Ultrasonography and magnetic resonance cholangiopancreatography were performed on various choledochal cyst types. The mean CBD cyst size was not statistically different between the two radiologies (p=0.3606). IHBR Cyst Shape and Radiological Scans Did Not Correlate (p=0.9610). The CBD cyst's form did not correlate with radiological scans (p=0.3132). All USG and MRCP CBD cysts were fusiform. USG and MRCP scans yielded similar CBD cyst shapes (p=1.0000). Both radiologies had similar IHBR cyst mean sizes (p=0.4501). [ABSTRACT FROM AUTHOR]
- Published
- 2023
50. Cost-effectiveness analysis of robot-assisted laparoscopic surgery for complex pediatric surgical conditions.
- Author
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Huang, Jiangrui, Huang, Zhong, Mei, Hong, Rong, Liying, Zhou, Yun, Guo, Jialing, Wan, Li, Xu, Yinhui, and Tang, Shaotao
- Abstract
Background: Robotics has been used safely and successfully in a variety of adult surgeries and is gradually gaining ground in pediatrics. While the benefits of robotic-assisted surgery in disease treatment are well recognized, its high cost has led to questions. To investigate whether robotic-assisted laparoscopic surgery (RALS) is cost-effective compared to conventional laparoscopic surgery (LS) in pediatric surgery, we attempted to construct a model to perform an analysis of these two surgical approaches using Python statistical analysis software. Methods: We selected four common complex pediatric surgical conditions (choledochal cyst, Hirschsprung's disease, vesicoureteral reflux, and congenital hydronephrosis) from three systems (pediatric hepatobiliary, gastroenterology, and urology). Models were constructed using Python statistical software to compare hospital costs and surgical outcomes for RALS and LS. In addition, we performed a preferred strategy analysis for both surgical modalities while assessing model uncertainty using one-way sensitivity analysis. Results: For the four diseases, the operative time decreased sequentially. The total inpatient costs of RALS were 10,816.72, 9145.44, 8414.29, 7973.58 dollars, respectively, yielding 1.789, 1.712, 1.749, 1.792 quality adjustment life years (QALYs) over two years post-operatively. The incremental cost of RALS relative to LS for each disease was 3523.44, 3200.20, 3049.79, 3043.66 dollars, respectively, with an incremental utility of 0.060, 0.054, 0.051, 0.050 QALYs. The incremental cost-effectiveness ratios (ICERs) for RALS for each of the four diseases were 58,724.01, 59,262.95, 59,799.79, 60,873.20 dollars/QALY, all less than 100,000 dollars/QALY. The cost of robot consumables was the main incremental cost of RALS and had the most significant impact on the model. Conclusion: For the four pediatric surgical conditions described above, RALS has higher inpatient costs than LS, but it has better postoperative outcomes, and all four RALS treatments are cost-effective. Children with complex diseases and long operative times appear to benefit more from RALS. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
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