1. Alcohol-Associated Liver Disease Outcomes: Critical Mechanisms of Liver Injury Progression
- Author
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Osna, Natalia A, Tikhanovich, Irina, Ortega-Ribera, Martí, Mueller, Sebastian, Zheng, Chaowen, Mueller, Johannes, Li, Siyuan, Sakane, Sadatsugu, Weber, Raquel Carvalho Gontijo, Kim, Hyun Young, Lee, Wonseok, Ganguly, Souradipta, Kimura, Yusuke, Liu, Xiao, Dhar, Debanjan, Diggle, Karin, Brenner, David A, Kisseleva, Tatiana, Attal, Neha, McKillop, Iain H, Chokshi, Shilpa, Mahato, Ram, Rasineni, Karuna, Szabo, Gyongyi, and Kharbanda, Kusum K
- Subjects
Biochemistry and Cell Biology ,Biomedical and Clinical Sciences ,Biological Sciences ,Digestive Diseases ,Liver Disease ,Hepatitis ,Chronic Liver Disease and Cirrhosis ,Alcoholism ,Alcohol Use and Health ,Substance Misuse ,Aetiology ,2.1 Biological and endogenous factors ,Oral and gastrointestinal ,Good Health and Well Being ,alcohol-associated liver disease ,epigenetics ,cell death ,hemolysis ,MetAld ,hepatic stellate cells ,fibrosis ,fatty acid binding protein 4 ,hepatocellular carcinoma ,models ,Liver ,Animals ,Humans ,Liver Diseases ,Alcoholic ,Disease Progression ,Epigenesis ,Genetic ,Hepatic Stellate Cells ,Biochemistry and cell biology ,Bioinformatics and computational biology ,Medical biotechnology - Abstract
Alcohol-associated liver disease (ALD) is a substantial cause of morbidity and mortality worldwide and represents a spectrum of liver injury beginning with hepatic steatosis (fatty liver) progressing to inflammation and culminating in cirrhosis. Multiple factors contribute to ALD progression and disease severity. Here, we overview several crucial mechanisms related to ALD end-stage outcome development, such as epigenetic changes, cell death, hemolysis, hepatic stellate cells activation, and hepatic fatty acid binding protein 4. Additionally, in this review, we also present two clinically relevant models using human precision-cut liver slices and hepatic organoids to examine ALD pathogenesis and progression.
- Published
- 2024