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859 results on '"Chojnacka Katarzyna"'

1. Stress and displacement patterns during orthodontic intervention in the maxilla of patients with cleft palate analyzed by finite element analysis: a systematic review

Author

Mikulewicz Marcin and Chojnacka Katarzyna

Subjects
Cleft palate, Finite element analysis, Orthodontic treatment, Dentistry, RK1-715
Abstract

Abstract Objective Rationale for the review in the context of what is already known about the evaluation of stress and displacement patterns using finite element analysis in the maxilla of patients with cleft palate after orthodontic intervention. Methods This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA). The protocol for this systematic review was registered with PROSPERO (CRD42020177494). The following databases were screened: Medline (via PubMed), Scopus, Embase, and Web of Science. Results The search identified 31 records. 15 articles were retrieved for full texts and 11 of them were considered eligible for inclusion by 2 authors. Eventually, 11 articles were included in the qualitative analysis. Conclusions Finite element analysis is an appropriate tool for studying and predicting force application points for better controlled expansion in patients with UCLP.

Published
2023
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36. Morphological and functional alterations in adult boar epididymis: Effects of prenatal and postnatal administration of flutamide

Author

Chojnacka Katarzyna, Kotula-Balak Malgorzata, Kopera-Sobota Ilona, Lydka Marta, Zak Dorota, and Bilinska Barbara

Subjects
Veterinary medicine, SF600-1100
Abstract

Abstract Background The dynamic cross-talk between epididymal cells is hormonally regulated and, in part, through direct cell-to-cell interactions. To date, no information is available regarding possible impact of anti-androgens on the proteins involved in the gap junctional communication within the boar epididymis. Thus, a question arised whether prenatal or postnatal exposure to an anti-androgen flutamide alters the expression of gap junction protein - connexin43 (Cx43) and androgen receptor (AR) expression in the caput, corpus and cauda epididymis and leads to delayed effects on morphology and function of adult pig epididymis. Methods First two experimental groups received flutamide prenatally on gestational days 20-28 and 80-88 (GD20 and GD80) and further two groups were exposed to flutamide postanatally on days 2-10 and 90-98 after birth (PD2 and PD90). Epididymides were collected from adult boars. Routine histology was performed using hematoxylin-eosin staining. The expression of Cx43 and AR were analyzed using immunohistochemistry and Western blotting. Both analyses were supported by quantitative approaches to demonstrate the variations of the expression levels following the treatment. Apoptotic cells were identified using TUNEL assay. Results Histological examination revealed differences in epididymal morphology of flutamide-exposed boars when compared to controls. Scarce spermatic content were seen within the corpus and cauda lumina of GD20, PD2 and PD90 groups. Concomitantly, frequency of epididymal cell apoptosis was significantly higher (p < 0.05) after exposure to flutamide at GD20. Moreover, in GD20, PD2, and PD90 groups, significantly lower AR expression (p < 0.05) was found in the principal and basal cells of the corpus and cauda regions, while in the stromal cells AR expression was significantly reduced (p < 0.05) along the epididymal duct. Concomitantly, a decrease in Cx43 expression (p < 0.05) was noticed in the stromal cells of the cauda region of GD20 and PD2 groups. This indicates high sensitivity of the stromal cells to androgen withdrawal. Conclusions The region-specific alterations in the epididymis morphology and scarce spermatic content within the lumina of the corpus and cauda indicate that flutamide can induce delayed effects on the epididymal function of the adult boar by decrease in AR protein levels that results in altered androgen signaling. This may cause disturbances in androgen-dependent processes including Cx43 (de)regulation, however, we can not exclude the possibility that in response to flutamide decreased Cx43 expression may represent one mechanism responsible for functional disturbance of the boar epididymis.

Published
2011
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