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1. Modified Gwakjeongtang for Diarrhea-Predominant Irritable Bowel Syndrome: Study Protocol for a Randomized, Double-Blind, Placebo-Controlled, Pilot Clinical Trial

Author

Choi Y, Ha NY, Kim AR, Jeong H, Kwon O, Park KS, Kim J, and Kim H

Subjects
irritable bowel syndrome, herbal medicine, gwakhyang-jeonggi-san, huoxiang-zhengqi-san, kkako-shoki-san, clinical protocol, Medicine (General), R5-920
Abstract

Yujin Choi,1,* Na-Yeon Ha,2,* Ae-Ran Kim,3 Haein Jeong,2 Ojin Kwon,1 Ki-Sun Park,1 Jieun Kim,1 Jinsung Kim,2 Hyungjun Kim1 1KM Science Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea; 2Division of Digestive Diseases, Department of Korean Internal Medicine, Kyung Hee University College of Korean Medicine, Kyung Hee University Korean Medicine Hospital, Seoul, Republic of Korea; 3R&D Strategy Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea*These authors contributed equally to this workCorrespondence: Jinsung Kim, Department of Digestive Diseases, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea, Tel +82 2 958 8895, Email oridoc@khu.ac.kr Hyungjun Kim, Division of KM Science Research, Korea Institute of Oriental Medicine, Daejeon, 34054, Republic of Korea, Tel +82 42 869 2796, Email heyjoon73@kiom.re.krIntroduction: Irritable bowel syndrome (IBS) is a chronic condition characterized by recurrent abdominal pain associated with bowel movements. Modified Gwakjeongtang (MGT), an herbal prescription rooted in traditional East Asian medicine, consists of thirteen botanical drugs known for their potential to enhance intestinal barrier function, regulate gastrointestinal motility, and exhibit anti-inflammatory and antioxidant properties. Despite a few previous clinical trials highlighting MGT’s potential for IBS symptom management, limited evidence exists with placebo control.Methods and Analysis: In this pilot randomized clinical trial protocol, we aim to exploratively evaluate the efficacy and safety of MGT in patients with diarrhea-predominant IBS (IBS-D) by comparing it with a placebo. A total of 60 IBS-D patients will be enrolled, and eligible participants will be randomly allocated to either the MGT or placebo groups. Over a 4-week period, they will receive MGT or placebo granules three times a day. The primary endpoint will be the overall response rate post-treatment, determined through daily assessments of abdominal pain intensity and stool consistency.Ethics and Dissemination: This clinical trial protocol has received approval from the Korean Ministry of Food and Drug Safety for an investigational new drug application and Institutional Review Board of the Kyung Hee University Korean Medicine Hospital. The research findings will be submitted and published in international peer-reviewed journal.Trial Registration: Clinical research information service (registration number: KCT0008523).Keywords: irritable bowel syndrome, herbal medicine, Gwakhyang-Jeonggi-San, Huoxiang-Zhengqi-San, Kkako-Shoki-San, clinical protocol

Published
2024

2. A Study to Evaluate the Effectiveness and Safety of Prephase Steroid Treatment before Remission Induction Chemotherapy in Patients with Pediatric Acute Lymphoblastic Leukemia Using Common Data Model-Based Real-World Data: A Retrospective Observational Study

Author

Choi Y, Kim BK, Won JH, Yoo JW, Choi W, Jung S, Kim JY, Choi IY, Chung NG, Lee JW, Choi JY, Kang HJ, and Lee H

Subjects
pediatric acute lymphoblastic leukemia, tumor lysis syndrome, remission induction chemotherapy, prephase steroid treatment, common data model, Infectious and parasitic diseases, RC109-216
Abstract

Yoona Choi,1,2,* Bo Kyung Kim,3,4,* Jung-Hyun Won,2,5 Jae Won Yoo,6 Wona Choi,7 Surin Jung,7 Jae Yoon Kim,7,8 In Young Choi,7 Nack-Gyun Chung,6 Jae Wook Lee,6 Jung Yoon Choi,3,4 Hyoung Jin Kang,3,4,9 Howard Lee1,2,5,10,11 1Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea; 2Center for Convergence Approaches in Drug Development, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea; 3Department of Pediatrics, Seoul National University Hospital, Seoul, Republic of Korea; 4Seoul National University Cancer Research Institute, Seoul, Republic of Korea; 5Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea; 6Department of Pediatrics, Seoul St. Mary’s Hospital, College of Medicine, the Catholic University of Korea, Seoul, Republic of Korea; 7Department of Medical Informatics, College of Medicine, the Catholic University of Korea, Seoul, Republic of Korea; 8Department of Biomedicine & Health Sciences, the Catholic University of Korea, Seoul, Republic of Korea; 9Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea; 10Advanced Institutes of Convergence Technology, Suwon, Republic of Korea; 11Department of Clinical Pharmacology and Therapeutics, Seoul National University Hospital, Seoul, Republic of Korea*These authors contributed equally to this workCorrespondence: Howard Lee, Department of Clinical Pharmacology and Therapeutics, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea, Email howardlee@snu.ac.kr Hyoung Jin Kang, Department of Pediatrics, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea, Email kanghj@snu.ac.krBackground: Rapid reduction of leukemic cells in the bone marrow during remission induction chemotherapy (RIC) can lead to significant complications such as tumor lysis syndrome (TLS). We investigated whether prephase steroid treatment before RIC could decrease TLS incidence and improve overall survival in pediatric patients with acute lymphoblastic leukemia (ALL).Methods: Data were extracted from the Common Data Model databases in two tertiary-care hospitals in Seoul, South Korea. Patients were classified into the treated or untreated group if they had received RIC with prephase steroid treatment ≥ 7 days before RIC in 2012– 2021 or not, respectively. Stabilized Inverse Probability of Treatment Weighting (sIPTW) was applied to ensure compatibility between the treated and untreated groups. The incidence of TLS within 14 days of starting RIC, overall survival (OS), and the incidence of adverse events of special interest were the primary endpoints. Multiple sensitivity analyses were performed.Results: Baseline characteristics were effectively balanced between the treated (n=308.4) and untreated (n=246.6) groups after sIPTW. Prephase steroid treatment was associated with a significant 88% reduction in the risk of TLS (OR 0.12, 95% CI: 0.03– 0.41). OS was numerically greater in the treated group than in the untreated group although the difference was not statistically significant (HR 0.64, 95% CI 0.25– 1.64). The treated group experienced significantly elevated risks for hyperbilirubinemia and hyperglycemia. The reduction in TLS risk by prephase steroid treatment was maintained in all of the sensitivity analyses.Conclusion: Prephase steroid treatment for ≥ 7 days before RIC in pediatric patients with ALL reduces the risk of TLS, while careful monitoring for toxicities is necessary. If adequately analyzed, real-world data can provide crucial effectiveness and safety information for proper management of pediatric patients with ALL, for whom prospective randomized studies may be difficult to perform for ethical and practical reasons.Keywords: pediatric acute lymphoblastic leukemia, tumor lysis syndrome, remission induction chemotherapy, prephase steroid treatment, common data model

Published
2024

3. Ultrasonic-Assisted Synthesis of Heterocyclic Curcumin Analogs as Antidiabetic, Antibacterial, and Antioxidant Agents Combined with in vitro and in silico Studies

Author

Zelelew D, Endale M, Melaku Y, Geremew T, Eswaramoorthy R, Tufa LT, Choi Y, and Lee J

Subjects
ultrasonic-irradiation, α-amylase, antibacterial, antioxidant, heterocyclic curcumin analogs, molecular docking, admet prediction, Biology (General), QH301-705.5, Biochemistry, QD415-436
Abstract

Demis Zelelew,1 Milkyas Endale,1 Yadessa Melaku,1 Teshome Geremew,2 Rajalakshmanan Eswaramoorthy,3 Lemma Teshome Tufa,1,4 Youngeun Choi,5 Jaebeom Lee5 1Department of Applied Chemistry, School of Applied Natural Science, Adama Science and Technology University, Adama, Ethiopia; 2Department of Applied Biology, School of Applied Natural Science, Adama Science and Technology University, Adama, Ethiopia; 3Department of Biomaterials, Saveetha Dental College and Hospital, Saveetha University, Chennai, 600 077, India; 4Research Institute of Materials Chemistry, Chungnam National University, Daejeon, 34134, Republic of Korea; 5Department of Chemistry, Department of Chemistry Engineering and Applied Chemistry, Chungnam National University, Daejeon, 34134, Republic of KoreaCorrespondence: Milkyas Endale; Demis Zelelew, Department of Applied Chemistry, School of Applied Natural Science, Adama Science and Technology University, P.O. Box 1888, Adama, Ethiopia, Email milkyas.endale@astu.edu.et; milkyasendale@yahoo.com; demis1921zelelew@gmail.comBackground: Heterocyclic analogs of curcumin have a wide range of therapeutic potential and the ability to control the activity of a variety of metabolic enzymes.Methods: 1H-NMR and 13C-NMR spectroscopic techniques were used to determine the structures of synthesized compounds. The agar disc diffusion method and α-amylase inhibition assay were used to examine the antibacterial and anti-diabetic potential of the compounds against α-amylase enzyme inhibitory activity, respectively. DPPH-free radical scavenging and lipid peroxidation inhibition assays were used to assess the in vitro antioxidant potential.Results and Discussion: In this work, nine heterocyclic analogs derived from curcumin precursors under ultrasonic irradiation were synthesized in excellent yields (81.4– 93.7%) with improved reaction time. Results of antibacterial activities revealed that compounds 8, and 11 displayed mean inhibition zone of 13.00± 0.57, and 19.66± 00 mm, respectively, compared to amoxicillin (12.87± 1.41 mm) at 500 μg/mL against E. coli, while compounds 8, 11 and 16 displayed mean inhibition zone of 17.67± 0.57, 14.33± 0.57 and 23.33± 00 mm, respectively, compared to amoxicillin (13.75± 1.83 mm) at 500 μg/mL against P. aeruginosa. Compound 11 displayed a mean inhibition zone of 11.33± 0.57 mm compared to amoxicillin (10.75± 1.83 mm) at 500 μg/mL against S. aureus. Compound 11 displayed higher binding affinities of − 7.5 and − 8.3 Kcal/mol with penicillin-binding proteins (PBPs) and β-lactamases producing bacterial strains, compared to amoxicillin (− 7.2 and − 7.9 Kcal/mol, respectively), these results are in good agreement with the in vitro antibacterial activities. In vitro antidiabetic potential on α-amylase enzyme revealed that compounds 11 (IC50=7.59 μg/mL) and 16 (IC50=4.08 μg/mL) have higher inhibitory activities than acarbose (IC50=8.0 μg/mL). Compound 8 showed promising antioxidant inhibition efficacy of DPPH (IC50 = 2.44 g/mL) compared to ascorbic acid (IC50=1.24 g/mL), while compound 16 revealed 89.9± 20.42% inhibition of peroxide generation showing its potential in reducing the development of lipid peroxides. In silico molecular docking analysis, results are in good agreement with in vitro biological activity. In silico ADMET profiles suggested the adequate oral drug-likeness potential of the compounds without adverse effects.Conclusion: According to our findings, both biological activities and in silico computational studies results demonstrated that compounds 8, 11, and 16 are promising α-amylase inhibitors and antibacterial agents against E. coli, P. aeruginosa, and S. aureus, whereas compound 8 was found to be a promising antioxidant agent.Keywords: ultrasonic-irradiation, α-amylase, antibacterial, antioxidant, heterocyclic curcumin analogs, molecular docking, ADMET prediction

Published
2023

4. Racial Differences and Contributory Cardiovascular and Non-Cardiovascular Risk Factors Towards Chronic Kidney Disease Progression

Author

Choi Y, Jacobs Jr DR, Kramer HJ, Shroff GR, Chang AR, and Duprez DA

Subjects
ckd progression, racial disparities, young adults, conventional risk factors, lung function, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Yuni Choi,1 David R Jacobs Jr,1 Holly J Kramer,2 Gautam R Shroff,3 Alexander R Chang,4 Daniel A Duprez5 1Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA; 2Departments of Public Health Sciences and Medicine, Loyola University Chicago, Maywood, IL, USA; 3Division of Cardiology and Department of Medicine, Hennepin Healthcare, University of Minnesota Medical School, Minneapolis, MN, USA; 4Departments of Population of Health Sciences and Nephrology, Geisinger, Danville, PA, USA; 5Cardiovascular Division, Department of Medicine, University of Minnesota, Minneapolis, MN, USACorrespondence: Daniel A Duprez, Cardiovascular Division, Department of Medicine, University of Minnesota, 420 Delaware St SE, MMC 508, Minneapolis, MN, 55455, USA, Tel + 1 612-624-4948, Fax + 1 612-626-4411, Email dupre007@umn.eduBackground: The prevalence of advanced chronic kidney disease (CKD) is higher in Black than in White Americans. We evaluated CKD progression in Black and White participants and the contribution of biological risk factors. We included the study of lung function (measured by forced vital capacity [FVC]), which is part of the emerging notion of interorgan cross-talk with the kidneys to racial differences in CKD progression.Methods: This longitudinal study included 2175 Black and 2207 White adult Coronary Artery Risk Development in Young Adults (CARDIA) participants. Estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (UACR) were measured at study year 10 (age 27– 41y) and every five years for 20 years. The outcome was CKD progression through no CKD, low, moderate, high, or very high-risk categories based on eGFR and UACR in combination. The association between race and CKD progression as well as the contribution of risk factors to racial differences were assessed in multivariable-adjusted Cox models.Results: Black participants had higher CKD transition probabilities than White participants and more prevalent risk factors during the 20-year period studied. Hazard ratios for CKD transition for Black (vs White participants) were 1.38 from No CKD into ≥ low risk, 2.25 from ≤ low risk into ≥ moderate risk, and 4.49 from ≤ moderate risk into ≥ high risk. Racial differences in CKD progression from No CKD into ≥ low risk were primarily explained by FVC (54.8%), hypertension (30.9%), and obesity (20.8%). In contrast, racial differences were less explained in more severe transitions.Conclusion: Black participants had a higher risk of CKD progression, and this discrepancy may be partly explained by FVC and conventional risk factors.Keywords: CKD progression, racial disparities, young adults, conventional risk factors, lung function

Published
2023

5. Network cost allocation methods for pay-as-bid peer-to-peer energy trading: A comparison

Author

Noorfatima N., Choi Y., Onen A., and Jung J.

Subjects
Peer-to-peer energy trading, Pay-as-bid, Network cost allocation, Network usage cost, Evaluation framework, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract

In pay-as-bid peer-to-peer (P2P) energy trading, various types of prosumers and consumers can participate, regardless of their offers. Thus, various types of participants impact the network differently. However, very few pay-as-bid P2P energy trading studies have specifically discussed appropriate compensation for network usage, although the market is implemented in existing utility-owned grids. Therefore, to improve the performance of pay-as-bid P2P energy trading, it is important to determine the appropriate compensation to utilities for network usage. This study aims to obtain an appropriate network cost allocation method for pay-as-bid P2P energy trading. Hence, the authors present a review of pay-as-bid P2P market mechanisms and various network cost allocation (NCA) methods. Additionally, a comprehensive evaluation framework is proposed to determine the most appropriate NCA method for the pay-as-bid P2P energy trading system. A comparison was made between various NCA methods to investigate the outcomes of the implementation of different NCA methods to various market conditions. The study constructs a case study based on the operator-oriented P2P model to represent the pay-as-bid P2P energy trading system. The simulation of pay-as-bid P2P energy trading with large participant number is applied in the IEEE 69-bus distribution system. The study concluded that applying the appropriate NCA method would improve the performance of pay-as-bid P2P energy trading operation.

Published
2022
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6. Association of Dietary Behaviors with Poor Sleep Quality and Increased Risk of Obstructive Sleep Apnea in Korean Military Service Members

Author

Choi Y, Son B, Shin WC, Nam SU, Lee J, Lim J, Kim S, Yang C, and Lee H

Subjects
sleep, dietary behavior, insomnia, obstructive sleep apnea, military, Psychiatry, RC435-571, Neurophysiology and neuropsychology, QP351-495
Abstract

Yujin Choi,1,* Byunwoo Son,2,* Woo-Chul Shin,3,4 Seong-uk Nam,5 Jaehong Lee,6 Jinwoong Lim,3,7 Sungha Kim,1 Changsop Yang,1 Hyeonhoon Lee8– 10 1KM Science Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea; 2Combined Dispensary, 7th Corps, Republic of Korea Army, Icheon, Republic of Korea; 3Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea; 4Medical Company, 1st Airborne Special Forces Brigade, Republic of Korea Army, Seoul, Republic of Korea; 5 28th Division, Republic of Korea Army, Yangju-si, Republic of Korea; 6Medical Corps, The Capital Defense Command, Seoul, Republic of Korea; 7Department of Acupuncture and Moxibustion, Wonkwang University Gwangju Korean Medicine Hospital, Gwangju, Republic of Korea; 8Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul, Republic of Korea; 9Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea; 10 9th Division, Republic of Korea Army, Goyang, Republic of Korea*These authors contributed equally to this workCorrespondence: Changsop Yang, KM Science Research Division, Korea Institute of Oriental Medicine, 1672, Yuseong-daero, Yuseong-gu, Daejeon, 34054, Republic of Korea, Tel +82-42-869-2705, Fax +82-42-868-9395, Email yangunja@kiom.re.kr Hyeonhoon Lee, Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea, Tel +82-2-2072-0505, Fax +82-2-747-5639, Email hhoon@snu.ac.krPurpose: Sleep quality among military service members is important for enhancing their capabilities and preventing psychiatric problems. We aimed to explore the association of dietary behaviors with poor sleep quality and increased risk of obstructive sleep apnea (OSA) in military men on active duty.Patients and Methods: A large-scale multi-site cross-sectional survey was conducted in five units of the Republic of Korea’s army. Poor sleep quality and increased risk of OSA were defined using the Pittsburgh sleep quality index (PSQI) and Berlin Questionnaire, respectively. Information on dietary behaviors, including the frequency of skipping breakfast, eating snacks, consuming a night meal, and overeating, were collected.Results: From August 2021 to September 2021, 4389 male respondents, mean age (20.8 ± 1.3 years), completed the survey; 2579 (58.8%) were assessed as having poor sleep quality, and 614 (14.0%) increased risk of OSA. After adjusting for lifestyle and occupational covariates, skipping breakfast 1– 2 times weekly was associated with an increased likelihood of experiencing poor sleep quality, compared with not skipping breakfast (odds ratio: 1.23 [95% CI 1.02– 1.47]). Eating night meals 5– 6 times weekly was also associated with poor sleep quality (odds ratio: 5.54 [95% CI 2.49– 14.18]). In addition, skipping breakfast daily (odds ratio: 2.28 [95% CI 1.27– 4.03]) and eating night meals daily (odds ratio: 2.30 [95% CI 1.21– 4.22]) were related to an increased risk of OSA.Conclusion: Dietary behaviors appear to be related to poor sleep quality and a high risk of OSA. To improve sleep quality, dietary factors could be considered when promoting health programs for military personnel in further research.Keywords: sleep, dietary behavior, insomnia, obstructive sleep apnea, military

Published
2022

7. Extracellular Traps: A Novel Therapeutic Target for Severe Asthma

Author

Choi Y, Luu QQ, and Park HS

Subjects
asthma, eosinophil extracellular trap, managements, neutrophil extracellular trap, severe asthma, therapeutics, Immunologic diseases. Allergy, RC581-607
Abstract

Youngwoo Choi,1 Quoc Quang Luu,1,2 Hae-Sim Park1,2 1Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea; 2Department of Biomedical Sciences, Graduate School of Ajou University, Suwon, KoreaCorrespondence: Hae-Sim Park, Department of Allergy and Clinical Immunology, Ajou University School of Medicine, 164 Worldcup-ro, Suwon, Korea, Tel +82-31-219-5000, Fax +82-31-219-6380, Email hspark@ajou.ac.krAbstract: Asthma is a complicated disease defined by a combination of clinical symptoms and physiological characteristics. Typically, asthma is diagnosed by the presence of episodic cough, wheezing, or dyspnea triggered by variable environmental factors (allergens and respiratory infections), and reversible airflow obstruction. To date, the majority of asthmatic patients have been adequately controlled by anti-inflammatory/bronchodilating agents, but those with severe asthma (SA) have not been sufficiently controlled by high-dose inhaled corticosteroids-long-acting beta-agonists plus additional controllers including leukotriene modifiers. Accordingly, these uncontrolled patients provoke a special issue, because they consume high healthcare resources, requiring innovative precision medicine solutions. Recently, phenotyping based on biomarkers of airway inflammation has led to elucidating the pathophysiological mechanism of SA, where emerging evidence has highlighted the significance of eosinophil or neutrophil extracellular traps contributing to the development of SA. Here, we aimed to provide current findings about extracellular traps as a novel therapeutic target for asthma to address medical unmet needs.Keywords: asthma, eosinophil, extracellular trap, neutrophil, therapeutics, unmet needs

Published
2022

8. The Incidence and Mortality Impact of Gastrointestinal Bleeding in Hospitalized COVID-19 Patients

Author

Makker J, Mantri N, Patel HK, Abbas H, Baiomi A, Sun H, Choi Y, Chilimuri S, and Nayudu SK

Subjects
sars-cov-2, covid-19, gastrointestinal bleeding, anticoagulation, coffee ground emesis, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Jasbir Makker,1,2 Nikhitha Mantri,1 Harish K Patel,1,2 Hafsa Abbas,1,2 Ahmed Baiomi,1,2 Haozhe Sun,1 Yongsub Choi,1 Sridhar Chilimuri,1,2 Suresh Kumar Nayudu1,2 1Division of Gastroenterology, BronxCare Hospital Center, Clinical Affiliate of Mt Sinai Health Systems and Academic Affiliate of Icahn School of Medicine, Bronx, NY, 10457, USA; 2Department of Medicine, BronxCare Hospital Center, Clinical Affiliate of Mt Sinai Health Systems and Academic Affiliate of Icahn School of Medicine, Bronx, NY, 10457, USACorrespondence: Jasbir MakkerDivision of Gastroenterology, Department of Medicine, BronxCare Hospital Center, Clinical Affiliate of Mt Sinai Health Systems and Academic Affiliate of Icahn School of Medicine, Bronx, NY, 10457, USAEmail jmakker@bronxcare.orgBackground: Patients requiring hospitalization to critical care units are at a higher risk for gastrointestinal (GI) bleeding. Although severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infection is predominantly a pulmonary disease, other serious manifestations including thromboembolic phenomenon are reported. Acute respiratory distress syndrome (ARDS) requiring mechanical ventilation, use of steroids and anticoagulation are all known to increase the risk of GI bleeding significantly.Aim: To study the incidence of GI bleeding and its impact on mortality in patients admitted with SARS-CoV-2.Methods: We retrospectively reviewed all patients admitted with SARS-CoV-2 from February 1, 2020 to April 15, 2020. We collected data including demographics, comorbid conditions, laboratory parameters, steroid and anticoagulant use. Coffee ground emesis, hematemesis, melena and hematochezia were defined as GI bleeding. All-cause mortality was reviewed for all patients included in the study. The relationship between GI bleeding and mortality was studied using logistic regression.Results: We had a total of 1206 patients hospitalized with SARS-CoV-2 infection with an all-cause mortality of 34% (n = 411). The overall incidence of GI bleeding was 3.1% (n = 37) with no significant difference between the patients who survived versus died during hospitalization (1.3% vs 1.5%, p = 0.77). Logistic regression analysis did not identify GI bleeding as an independent predictor of mortality. Therapeutic doses of anticoagulation were administered in 13.3% (n = 161) of patients, of which 6.8% (n = 11) developed GI bleeding. Patients were more likely to develop GI bleeding with use of therapeutic doses of anticoagulation (29.7% vs 12.8%, p = 0.003), steroids (37.8% vs 18.5%, p = 0.003) and mechanical ventilation (48.6% vs 30.4%, p = 0.018).Conclusion: Patients hospitalized with SARS-CoV-2 infection are at risk of gastrointestinal bleeding. Therapeutic doses of anticoagulation, mechanical ventilation and steroid use are significant risk factors for GI bleeding. However, GI bleeding did not significantly alter the mortality rates in SARS-CoV-2-infected patients.Keywords: SARS-CoV-2, COVID-19, gastrointestinal bleeding, anticoagulation, coffee ground emesis

Published
2021

9. Herbal Medicine for Patients with Cognitive Impairment: An Observational Study

Author

Choi Y, Kim AR, Lee JY, Kim HS, Yang C, Kim JK, Go Y, and Jung IC

Subjects
mild cognitive impairment, mild dementia, herbal medicine, korean medicine, traditional east asian medicine, observational study, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Yujin Choi,1 Ae-Ran Kim,2 Ji-Yoon Lee,3 Hae Sook Kim,3 Changsop Yang,1 Jae Kwang Kim,4 Younghoon Go,4 In Chul Jung3 1KM Science Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea; 2R&D Strategy Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea; 3Department of Neuropsychiatry, College of Korean Medicine, Daejeon University, Daejeon, Republic of Korea; 4KM Application Center, Korea Institute of Oriental Medicine, Daegu, Republic of KoreaCorrespondence: In Chul JungDepartment of Neuropsychiatry, College of Korean Medicine, Daejeon University, 75 Daedeok-daero 176beon-gil, Seo-gu, Daejeon, Republic of KoreaTel +82-42-470-9129Fax +82-42-470-9005Email npjeong@dju.krPurpose: The potential effects of herbal medicine for patients with cognitive disorders have been reported in various human and animal studies. This study aimed to explore the effect of herbal medicine treatment according to the Korean Medicine (KM) pattern identification for patients with mild cognitive impairment and early dementia.Patients and Methods: Twenty patients with mild cognitive impairment or mild dementia who planned to receive herbal medicine treatment were enrolled. Herbal formulae were prescribed based on the KM pattern for 12– 24 weeks. Seoul Neuropsychological Screening Battery II (SNSB-II) and Montreal Cognitive Assessment (MoCA) were assessed at the baseline, after 12 weeks, and after 24 weeks (Trial registration: cris.nih.go.kr, KCT0004799).Results: Herbal medicine products, including Yukmijihwang-tang, Samhwangsasim-tang, Palmul-tang, Banhasasim-tang, and Yukgunja-tang, were prescribed to the patients. Among the SNSB-II five cognitive function domains, the T scores for language, visuospatial function, memory, and frontal/executive function increased over time. The MoCA score also improved following the treatment (mean difference 4.23 [95% CI: 2.60, 5.86], p < 0.0001 at 12-week follow-up compared to the baseline). Considering the KM pattern scores, phlegm-dampness and fire-heat scores tended to improve after the treatment. No serious adverse events related to the intervention were reported.Conclusion: The potential effect of herbal medicine formulae products on improving cognitive functions in patients with cognitive impairment was observed. Further research is needed to objectify the KM pattern identification process and evaluate the KM pattern-related signs and symptoms.Keywords: mild cognitive impairment, mild dementia, herbal medicine, Korean medicine, traditional east Asian medicine, observational study

Published
2021

10. Search for $h_b(2P)\to\gamma\chi_{bJ}(1P)$ at $\sqrt{s} = 10.860$ GeV

Author

Belle Collaboration, Boschetti, A., Mussa, R., Tamponi, U., Adachi, I., Aihara, H., Asner, D. M., Aushev, T., Ayad, R., Banerjee, Sw., Belous, K., Bennett, J., Bessner, M., Biswas, D., Bobrov, A., Bodrov, D., Bozek, A., Bračko, M., Branchini, P., Browder, T. E., Budano, A., Chang, M. -C., Cheon, B. G., Chilikin, K., Cho, K., Choi, S. -K., Choi, Y., Choudhury, S., De Nardo, G., De Pietro, G., Dhamija, R., Di Capua, F., Doležal, Z., Dong, T. V., Ecker, P., Epifanov, D., Ferlewicz, D., Fulsom, B. G., Garg, R., Gaur, V., Garmash, A., Giri, A., Goldenzweig, P., Graziani, E., Gu, T., Guan, Y., Gudkova, K., Hadjivasiliou, C., Hara, T., Hayasaka, K., Hayashii, H., Hazra, S., Hou, W. -S., Hsu, C. -L., Inami, K., Ipsita, N., Itoh, R., Iwasaki, M., Jacobs, W. W., Jin, Y., Kawasaki, T., Kiesling, C., Kim, C. H., Kim, D. Y., Kim, K. -H., Kim, Y. -K., Kinoshita, K., Kodyš, P., Korpar, S., Kovalenko, E., Križan, P., Krokovny, P., Kumar, R., Kumara, K., Kwon, Y. -J., Lam, T., Levit, D., Li, L. K., Li, Y. B., Gioi, L. Li, Liventsev, D., Ma, Y., Masuda, M., Matsuda, T., Matvienko, D., Meier, F., Merola, M., Miyabayashi, K., Mizuk, R., Mohanty, G. B., Nakao, M., Natkaniec, Z., Natochii, A., Nayak, L., Nayak, M., Nishida, S., Ogawa, S., Ono, H., Pakhlova, G., Park, J., Park, S. -H., Passeri, A., Patra, S., Paul, S., Pedlar, T. K., Pestotnik, R., Piilonen, L. E., Podobnik, T., Prencipe, E., Prim, M. T., Rout, N., Russo, G., Sandilya, S., Santelj, L., Savinov, V., Schnell, G., Schwanda, C., Seino, Y., Senyo, K., Shan, W., Shen, C. P., Shiu, J. -G., Sokolov, A., Solovieva, E., Starič, M., Sumihama, M., Takizawa, M., Tanida, K., Tenchini, F., Tiwary, R., Uchida, M., Unno, Y., Uno, S., Vinokurova, A., Wang, E., Wang, M. -Z., Wang, X. L., Won, E., Yabsley, B. D., Yelton, J., Yin, J. H., Yook, Y., and Yuan, L.

Subjects
High Energy Physics - Experiment
Abstract

In the bottomonium sector, the hindered magnetic dipole (M1) transitions between P-wave states $h_b(2P) \rightarrow \chi_{bJ}(1P) \gamma$, $J=0, \, 1, \, 2$, are expected to be severely suppressed according to the Relativized Quark Model, due to the spin flip of the $b$ quark. Nevertheless, a recent model following the coupled-channel approach predicts the corresponding branching fractions to be enhanced by orders of magnitude. In this Letter, we report the first search for such transitions. We find no significant signals and set upper limits at 90% CL on the corresponding branching fractions: $\mathcal{B}[h_b(2P)\to\gamma\chi_{b0}(1P)] < 2.7 \times 10^{-1}$, $\mathcal{B}[h_b(2P)\to\gamma\chi_{b1}(1P)] < 5.4 \times 10^{-3}$ and $\mathcal{B}[h_b(2P)\to\gamma\chi_{b2}(1P)] < 1.3 \times 10^{-2}$. These values help to constrain the parameters of the coupled-channel models. The results are obtained using a $121.4 \, fb^{-1}$ data sample taken around $\sqrt{s}= 10.860 \, GeV$ with the Belle detector at the KEKB asymmetric-energy $e^+e^-$ collider.

Published
2024

11. Quantum Frequency Combs with Path Identity for Quantum Remote Sensing

Author

Dalvit, D. A. R., Volkoff, T. J., Choi, Y. -S., Azad, A. K., Chen, H. -T., and Milonni, P. W.

Subjects
Quantum Physics, Physics - Applied Physics, Physics - Optics
Abstract

Quantum sensing promises to revolutionize sensing applications by employing quantum states of light or matter as sensing probes. Photons are the clear choice as quantum probes for remote sensing because they can travel to and interact with a distant target. Existing schemes are mainly based on the quantum illumination framework, which requires a quantum memory to store a single photon of an initially entangled pair until its twin reflects off a target and returns for final correlation measurements. Existing demonstrations are limited to tabletop experiments, and expanding the sensing range faces various roadblocks, including long-time quantum storage and photon loss and noise when transmitting quantum signals over long distances. We propose a novel quantum sensing framework that addresses these challenges using quantum frequency combs with path identity for remote sensing of signatures (``qCOMBPASS"). The combination of one key quantum phenomenon and two quantum resources, namely quantum induced coherence by path identity, quantum frequency combs, and two-mode squeezed light, allows for quantum remote sensing without requiring a quantum memory. The proposed scheme is akin to a quantum radar based on entangled frequency comb pairs that uses path identity to detect/range/sense a remote target of interest by measuring pulses of one comb in the pair that never flew to target, but that contains target information ``teleported" by quantum-induced coherence from the other comb in the pair that did fly to target but is not detected., Comment: To appear in PRX

Published
2024

12. Discovery and Spectroscopic Confirmation of Aquarius III: A Low-Mass Milky Way Satellite Galaxy

Author

Cerny, W., Chiti, A., Geha, M., Mutlu-Pakdil, B., Drlica-Wagner, A., Tan, C. Y., Adamów, M., Pace, A. B., Simon, J. D., Sand, D. J., Ji, A. P., Li, T. S., Vivas, A. K., Bell, E. F., Carlin, J. L., Carballo-Bello, J. A., Chaturvedi, A., Choi, Y., Doliva-Dolinsky, A., Gnedin, O. Y., Limberg, G., Martínez-Vázquez, C. E., Mau, S., Medina, G. E., Navabi, M., Noël, N. E. D., Placco, V. M., Riley, A. H., Roederer, I. U., Stringfellow, G. S., Bom, C. R., Ferguson, P. S., James, D. J., Martínez-Delgado, D., Massana, P., Nidever, D. L., Sakowska, J. D., Santana-Silva, L., Sherman, N. F., and Tollerud, E. J.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

We present the discovery of Aquarius III, an ultra-faint Milky Way satellite galaxy identified in the second data release of the DECam Local Volume Exploration (DELVE) survey. Based on deeper follow-up imaging with DECam, we find that Aquarius III is a low-luminosity ($M_V = -2.5^{+0.3}_{-0.5}$; $L_V = 850^{+380}_{-260} \ L_{\odot}$), extended ($r_{1/2} = 41^{+9}_{-8}$ pc) stellar system located in the outer halo ($D_{\odot} = 85 \pm 4$ kpc). From medium-resolution Keck/DEIMOS spectroscopy, we identify 11 member stars and measure a mean heliocentric radial velocity of $v_{\rm sys} = -13.1^{+1.0}_{-0.9} \ \rm km \ s^{-1}$ for the system and place an upper limit of $\sigma_v < 3.5 \rm \ km \ s^{-1}$ ($\sigma_v < 1.6 \rm \ km \ s^{-1}$) on its velocity dispersion at the 95% (68%) credible level. Based on Calcium-Triplet-based metallicities of the six brightest red giant members, we find that Aquarius III is very metal-poor ([Fe/H]$ = -2.61 \pm 0.21$) with a statistically-significant metallicity spread ($\sigma_{\rm [Fe/H]} = 0.46^{+0.26}_{-0.14}$ dex). We interpret this metallicity spread as strong evidence that the system is a dwarf galaxy as opposed to a star cluster. Combining our velocity measurement with $Gaia$ proper motions, we find that Aquarius III is currently situated near its orbital pericenter in the outer halo ($r_{\rm peri} = 78 \pm 7$ kpc) and that it is plausibly on first infall onto the Milky Way. This orbital history likely precludes significant tidal disruption from the Galactic disk, notably unlike other satellites with comparably low velocity dispersion limits in the literature. Thus, if further velocity measurements confirm that its velocity dispersion is truly below $\sigma_v \lesssim 2 \rm \ km \ s^{-1}$, Aquarius III may serve as a useful laboratory for probing galaxy formation physics in low-mass halos., Comment: 25 pages, 7 figures. Submitted to AAS Journals

Published
2024

13. Clinical Characteristics of COPD Patients According to COPD Assessment Test (CAT) Score Level: Cross-Sectional Study

Author

Gil HI, Zo S, Jones PW, Kim BG, Kang N, Choi Y, Cho HK, Kang D, Cho J, Park HY, and Shin SH

Subjects
copd, copd assessment test, patient reported outcome, symptom, Diseases of the respiratory system, RC705-779
Abstract

Hyun-Il Gil,1,* Sungmin Zo,2,* Paul W Jones,3,4 Bo-Guen Kim,2 Noeul Kang,2 Yeonseok Choi,5 Hyun Kyu Cho,6 Danbee Kang,7 Juhee Cho,7 Hye Yun Park,2 Sun Hye Shin2 1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; 2Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; 3Institute For Infection and Immunity, St George’s University of London, London, UK; 4Value Evidence and Outcomes, Global Medical R&D, GlaxoSmithKline, Uxbridge, UK; 5Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Republic of Korea; 6Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea; 7Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University, Seoul, Republic of Korea*These authors contributed equally to this workCorrespondence: Sun Hye Shin; Hye Yun ParkDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of KoreaTel +82-2-3410-3429Fax +82-2-3410-3849Email freshsunhye@gmail.com; hyeyunpark@skku.eduPurpose: The chronic obstructive pulmonary disease (COPD) assessment test (CAT) is widely used to assess the impact of COPD symptoms on health status. Whilst the CAT consists of eight different items, details on the distribution of each item are limited. This study aimed to investigate the distribution and clinical implication of each CAT item, stratified by CAT severity group, in stable COPD patients.Patients and Methods: This was a cross-sectional study at a single referral hospital in South Korea. Spirometry confirmed COPD patients with CAT measured at the first clinical visit were retrospectively identified. Patients were categorized into three groups: low (0 ≤ CAT < 10), medium (10 ≤ CAT < 20), and high (20 ≤ CAT ≤ 40) impact group. For the purpose of this analysis, the first four items (cough, sputum, chest tightness, and dyspnea) and the remaining four items (activities, confidence, sleep and energy) were also grouped as “pulmonary” and “extra-pulmonary”, respectively.Results: A total of 815 patients were included, and mean (SD) forced expiratory volume in 1 s (FEV1) was 62.8 (17.4) % pred. Among them, 300 patients (36.8%) were in the high impact group and had a greater exacerbation history and lower lung function. The proportion of “extra-pulmonary” items score was greater in patients with higher total CAT scores, with the activity and confidence items showing higher scores.Conclusion: In our study, in addition to dyspnea, activity limitation is a particular problem in individual patients with higher CAT total scores, for which physicians need to pay more attention. Our study suggests that whilst CAT total score captures the overall impact of COPD, each item of the CAT contains potentially useful information in understanding the patient’s symptom burden.Keywords: COPD, COPD assessment test, patient reported outcome, symptom

Published
2021

14. Favorable Response to Long-Term Azithromycin Therapy in Bronchiectasis Patients with Chronic Airflow Obstruction Compared to Chronic Obstructive Pulmonary Disease Patients without Bronchiectasis

Author

Choi Y, Shin SH, Lee H, Cho HK, Im Y, Kang N, Choi HS, and Park HY

Subjects
copd, bronchiectasis, azithromycin, exacerbation, Diseases of the respiratory system, RC705-779
Abstract

Yeonseok Choi,1,* Sun Hye Shin,1,* Hyun Lee,2 Hyun Kyu Cho,1 Yunjoo Im,1 Noeul Kang,1 Hye Sook Choi,3 Hye Yun Park1 1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; 2Division of Pulmonary Medicine and Allergy, Department of Internal Medicine, Hanyang University College of Medicine, Seoul, South Korea; 3Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Kyung Hee University Hospital, Seoul, South Korea*These authors contributed equally to this workCorrespondence: Hye Yun ParkDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South KoreaTel +82-2-3410-3429Fax +82-2-3410-3849Email hyeyunpark@skku.eduPurpose: Long-term macrolide treatment is recommended for patients with chronic obstructive pulmonary disease (COPD) with frequent exacerbations. Bronchiectasis is a common comorbid condition in patients with COPD, for which long-term azithromycin is effective in preventing exacerbation. This study aimed to compare the effect of long-term azithromycin between bronchiectasis patients with chronic airflow obstruction (CAO) and COPD patients without bronchiectasis.Patients and Methods: Patients with CAO who received azithromycin for more than 12 weeks were retrospectively identified at a single referral hospital. CAO was defined as a post-bronchodilator forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) < 0.7, and bronchiectasis was determined using computed tomography. The development of exacerbation and symptom improvement were compared between bronchiectasis patients with CAO and COPD patients without bronchiectasis.Results: A total of 59 patients (43 in bronchiectasis with CAO group vs 16 in COPD without bronchiectasis group) were included in this study. Compared to COPD patients without bronchiectasis, those in bronchiectasis with CAO group were younger, more likely to be female, and never smokers. There was no difference in the previous exacerbation history or FEV1 between the two groups. The median duration of azithromycin treatment was 15 months (interquartile range, 8– 25 months). At the 12-month follow-up, the development of ≥ 2 moderate or ≥ 1 severe exacerbations was significantly lower in bronchiectasis with CAO group than in COPD without bronchiectasis group (46.5% vs 87.5%, P = 0.005). The proportion of patients with symptom improvement determined by the COPD assessment test score was also significantly higher in bronchiectasis with CAO group than COPD without bronchiectasis group at the 12-month follow-up (68.2% vs 16.7%, P = 0.004).Conclusion: Bronchiectasis patients with CAO could benefit more from long-term azithromycin treatment than COPD patients without bronchiectasis.Keywords: COPD, bronchiectasis, azithromycin, exacerbation

Published
2021

15. Photometric Redshifts Probability Density Estimation from Recurrent Neural Networks in the DECam Local Volume Exploration Survey Data Release 2

Author

Teixeira, G., Bom, C. R., Santana-Silva, L., Fraga, B. M. O., Darc, P., Teixeira, R., Wu, J. F., Ferguson, P. S., Martínez-Vázquez, C. E., Riley, A. H., Drlica-Wagner, A., Choi, Y., Mutlu-Pakdil, B., Pace, A. B., Sakowska, J. D., and Stringfellow, G. S.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Photometric wide-field surveys are imaging the sky in unprecedented detail. These surveys face a significant challenge in efficiently estimating galactic photometric redshifts while accurately quantifying associated uncertainties. In this work, we address this challenge by exploring the estimation of Probability Density Functions (PDFs) for the photometric redshifts of galaxies across a vast area of 17,000 square degrees, encompassing objects with a median 5$\sigma$ point-source depth of $g$ = 24.3, $r$ = 23.9, $i$ = 23.5, and $z$ = 22.8 mag. Our approach uses deep learning, specifically integrating a Recurrent Neural Network architecture with a Mixture Density Network, to leverage magnitudes and colors as input features for constructing photometric redshift PDFs across the whole DECam Local Volume Exploration (DELVE) survey sky footprint. Subsequently, we rigorously evaluate the reliability and robustness of our estimation methodology, gauging its performance against other well-established machine learning methods to ensure the quality of our redshift estimations. Our best results constrain photometric redshifts with the bias of $-0.0013$, a scatter of $0.0293$, and an outlier fraction of $5.1\%$. These point estimates are accompanied by well-calibrated PDFs evaluated using diagnostic tools such as Probability Integral Transform and Odds distribution. We also address the problem of the accessibility of PDFs in terms of disk space storage and the time demand required to generate their corresponding parameters. We present a novel Autoencoder model that reduces the size of PDF parameter arrays to one-sixth of their original length, significantly decreasing the time required for PDF generation to one-eighth of the time needed when generating PDFs directly from the magnitudes., Comment: 22 pages, 14 figures

Published
2024

16. A Pride of Satellites in the Constellation Leo? Discovery of the Leo VI Milky Way Satellite Galaxy with DELVE Early Data Release 3

Author

Tan, C. Y., Cerny, W., Drlica-Wagner, A., Pace, A. B., Geha, M., Ji, A. P., Li, T. S., Adamów, M., Anbajagane, D., Bom, C. R., Carballo-Bello, J. A., Carlin, J. L., Chang, C., Choi, Y., Collins, M. L. M., Doliva-Dolinsky, A., Ferguson, P. S., Gruendl, R. A., James, D. J., Limberg, G., Navabi, M., Martínez-Delgado, D., Martínez-Vázquez, C. E., Medina, G. E., Mutlu-Pakdil, B., Nidever, D. L., Noël, N. E. D., Riley, A. H., Sakowska, J. D., Sand, D. J., Sharp, J., Stringfellow, G. S., Tolley, C., and Vivas, A. K.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

We report the discovery and spectroscopic confirmation of an ultra-faint Milky Way (MW) satellite in the constellation of Leo. This system was discovered as a spatial overdensity of resolved stars observed with Dark Energy Camera (DECam) data from an early version of the third data release of the DECam Local Volume Exploration survey (DELVE EDR3). The low luminosity ($M_V = -3.56_{-0.37}^{+0.47}$; $L_V = 2300_{-800}^{+1000} L_\odot$), large size ($r_{1/2} = 90_{-30}^{+30}$ pc), and large heliocentric distance ($D = 111_{-4}^{+7}$ kpc) are all consistent with the population of ultra-faint dwarf galaxies (UFDs). Using Keck/DEIMOS observations of the system, we were able to spectroscopically confirm 11 member stars, while measuring a mass to light ratio of $1000_{-700}^{+1900} M_\odot/L_\odot$ and a non-zero metallicity dispersion of $\sigma_{[\rm Fe/H]}=0.33_{-0.14}^{+0.19}$, further confirming Leo VI's identity as an UFD. While the system has an highly elliptical shape, $\epsilon = 0.54_{-0.29}^{+0.19}$, we do not find any evidence that it is tidally disrupting. Moreover, despite its apparent on-sky proximity to members of the proposed Crater-Leo infall group, its relatively lower heliocentric distance and inconsistent position in energy-angular momentum space with the other group members make it unlikely for it to be part of the proposed infall group., Comment: 21 pages, 11 figures, 2 tables; to be submitted to AAS Journals

Published
2024

17. Evidence of $h_{b}(\text{2P}) \to \Upsilon(\text{1S})\eta$ decay and search for $h_{b}(\text{1P,2P}) \to \Upsilon(\text{1S})\pi^0$ with the Belle detector

Author

Belle Collaboration, Kovalenko, E., Adachi, I., Aihara, H., Asner, D. M., Aushev, T., Ayad, R., Babu, V., Banerjee, Sw., Belous, K., Bennett, J., Bessner, M., Bilka, T., Biswas, D., Bobrov, A., Bodrov, D., Bondar, A., Bozek, A., Bračko, M., Branchini, P., Browder, T. E., Budano, A., Campajola, M., Chang, M. -C., Cheon, B. G., Chilikin, K., Cho, H. E., Cho, K., Cho, S. -J., Choi, S. -K., Choi, Y., Choudhury, S., Dash, N., De Nardo, G., De Pietro, G., Dhamija, R., Di Capua, F., Doležal, Z., Dong, T. V., Dubey, S., Ecker, P., Epifanov, D., Ferlewicz, D., Fulsom, B. G., Garg, R., Gaur, V., Garmash, A., Giri, A., Goldenzweig, P., Graziani, E., Gu, T., Guan, Y., Gudkova, K., Hadjivasiliou, C., Hara, T., Hayasaka, K., Hazra, S., Hou, W. -S., Hsu, C. -L., Inami, K., Ipsita, N., Ishikawa, A., Itoh, R., Iwasaki, M., Jacobs, W. W., Jin, Y., Kawasaki, T., Kiesling, C., Kim, C. H., Kim, D. Y., Kim, K. -H., Kim, Y. -K., Kinoshita, K., Kodyš, P., Korobov, A., Korpar, S., Križan, P., Krokovny, P., Kuhr, T., Kumar, R., Kumara, K., Kuzmin, A., Kwon, Y. -J., Lai, Y. -T., Lam, T., Levit, D., Li, L. K., Gioi, L. Li, Libby, J., Liventsev, D., Ma, Y., Martini, A., Masuda, M., Matsuda, T., Matvienko, D., Meier, F., Merola, M., Miyabayashi, K., Mizuk, R., Mohanty, G. B., Mussa, R., Nakamura, I., Nakao, M., Natkaniec, Z., Natochii, A., Nayak, L., Nayak, M., Niiyama, M., Nishida, S., Ogawa, S., Ono, H., Pakhlova, G., Pardi, S., Park, J., Park, S. -H., Passeri, A., Patra, S., Paul, S., Pedlar, T. K., Pestotnik, R., Piilonen, L. E., Podobnik, T., Prencipe, E., Prim, M. T., Purohit, M. V., Rout, N., Russo, G., Sandilya, S., Santelj, L., Savinov, V., Schnell, G., Schwanda, C., Seino, Y., Senyo, K., Sevior, M. E., Shan, W., Sharma, C., Shiu, J. -G., Shwartz, B., Sokolov, A., Solovieva, E., Starič, M., Sumihama, M., Takizawa, M., Tamponi, U., Tanida, K., Tenchini, F., Tiwary, R., Uchida, M., Unno, Y., Uno, S., Usov, Y., Vinokurova, A., Wang, D., Wang, E., Wang, M. -Z., Wang, X. L., Won, E., Yabsley, B. D., Yan, W., Yang, S. B., Yelton, J., Yin, J. H., Yook, Y., Yuan, C. Z., Zhang, Z. P., and Zhilich, V.

Subjects
High Energy Physics - Experiment
Abstract

We report the first evidence for the $h_{b}(\text{2P}) \to \Upsilon(\text{1S})\eta$ transition with a significance of $3.5$ standard deviations. The decay branching fraction is measured to be $\mathcal{B}[h_{b}(\text{2P}) \to \Upsilon(\text{1S})\eta]=(7.1 ~^{+3.7} _{-3.2}\pm 0.8)\times10^{-3}$, which is noticeably smaller than expected. We also set upper limits on $\pi^0$ transitions of $\mathcal{B}[h_{b}(\text{2P}) \to \Upsilon(\text{1S})\pi^0] < 1.8\times10^{-3}$, and $\mathcal{B}[h_{b}(\text{1P})\to \Upsilon(\text{1S})\pi^0] < 1.8\times10^{-3}$, at the $90\%$ confidence level. These results are obtained with a $131.4$~fb$^{-1}$ data sample collected near the $\Upsilon(\text{5S})$ resonance with the Belle detector at the KEKB asymmetric-energy $e^+e^-$ collider., Comment: to be submitted to PRL

Published
2024

18. Study of $\chi_{bJ}(2P)\to\omega\Upsilon(1S)$ at Belle

Author

Belle Collaboration, Stottler, Z. S., Pedlar, T. K., Fulsom, B. G., Adachi, I., Adamczyk, K., Aihara, H., Said, S. Al, Asner, D. M., Atmacan, H., Aushev, T., Ayad, R., Babu, V., Banerjee, Sw., Bauer, M., Behera, P., Belous, K., Bennett, J., Bernlochner, F., Bessner, M., Bilka, T., Biswas, D., Bobrov, A., Bodrov, D., Bonvicini, G., Borah, J., Bozek, A., Branchini, P., Browder, T. E., Budano, A., Campajola, M., Cao, L., Červenkov, D., Chang, M. -C., Cheon, B. G., Chilikin, K., Cho, H. E., Cho, K., Choi, S. -K., Choi, Y., Choudhury, S., Cinabro, D., Das, S., De Nardo, G., De Pietro, G., Dhamija, R., Di Capua, F., Doležal, Z., Dong, T. V., Dubey, S., Ecker, P., Epifanov, D., Ferber, T., Ferlewicz, D., Gaur, V., Garmash, A., Giri, A., Goldenzweig, P., Graziani, E., Gu, T., Guan, Y., Gudkova, K., Hadjivasiliou, C., Hara, T., Hayasaka, K., Hazra, S., Hedges, M. T., Herrmann, D., Hou, W. -S., Hsu, C. -L., Inami, K., Ipsita, N., Ishikawa, A., Itoh, R., Iwasaki, M., Iwasaki, Y., Jacobs, W. W., Jia, S., Jin, Y., Kaliyar, A. B., Kawasaki, T., Kiesling, C., Kim, C. H., Kim, D. Y., Kim, K. -H., Kim, Y. -K., Kodyš, P., Korobov, A., Korpar, S., Kovalenko, E., Križan, P., Krokovny, P., Kuhr, T., Kumar, M., Kumar, R., Kumara, K., Kuzmin, A., Kwon, Y. -J., Lai, Y. -T., Lam, T., Laurenza, M., Lee, S. C., Levit, D., Lewis, P., Li, L. K., Libby, J., Lieret, K., Liventsev, D., Luo, T., Ma, Y., Masuda, M., Maurya, S. K., Meier, F., Merola, M., Miyabayashi, K., Mohanty, G. B., Nakamura, I., Nakao, M., Natochii, A., Nayak, L., Nisar, N. K., Nishida, S., Ogawa, K., Ogawa, S., Ono, H., Oskin, P., Pakhlov, P., Pakhlova, G., Pang, T., Pardi, S., Park, J., Park, S. -H., Patra, S., Paul, S., Pestotnik, R., Piilonen, L. E., Podobnik, T., Prencipe, E., Prim, M. T., Rout, N., Russo, G., Sandilya, S., Sangal, A., Santelj, L., Savinov, V., Schnell, G., Schwanda, C., Seino, Y., Senyo, K., Shan, W., Shapkin, M., Sharma, C., Shiu, J. -G., Sokolov, A., Solovieva, E., Starič, M., Sumihama, M., Sutcliffe, W., Takizawa, M., Tanida, K., Tenchini, F., Tiwary, R., Uchida, M., Unno, Y., Uno, S., Vahsen, S. E., Varner, G., Wang, D., Wang, E., Wang, M. -Z., Watanuki, S., Werbycka, O., Won, E., Yabsley, B. D., Yan, W., Yin, J. H., Yuan, C. Z., Yuan, L., Yusa, Y., Zhang, Z. P., Zhilich, V., and Zhukova, V.

Subjects
High Energy Physics - Experiment
Abstract

We report a study of the hadronic transitions $\chi_{bJ}(2P)\to\omega\Upsilon(1S)$, with $\omega\to\pi^{+}\pi^{-}\pi^{0}$, using $28.2\times10^6~\Upsilon(3S)$ mesons recorded by the Belle detector. We present the first evidence for the near--threshold transition $\chi_{b0}(2P)\to\omega\Upsilon(1S)$, the analog of the charm sector decay $\chi_{c1}(3872)\to\omega J/\psi$, with a branching fraction of $B\big(\chi_{b0}(2P)\to\omega\Upsilon(1S)\big) = \big(0.55\pm0.19\pm0.07\big)\%$. We also obtain branching fractions of $B\big(\chi_{b1}(2P)\to\omega\Upsilon(1S)\big) = \big(2.39{}^{+0.20}_{-0.19}\pm0.24\big)\%$ and $B\big(\chi_{b2}(2P)\to\omega\Upsilon(1S)\big) = \big(0.47{}^{+0.13}_{-0.12}\pm0.06\big)\%$, confirming the measurement of the $\omega$ transitions of the $J=1,2~P$--wave states. The ratio for the $J=2$ to $J=1$ transitions is also measured and found to differ by 3.3 standard deviations from the expected value in the QCD multipole expansion., Comment: 6 pages, 2 figures

Published
2024

19. Search for charmed baryons in the $\Lambda_c^+\eta$ system and measurement of the branching fractions of $\Lambda_c(2880)^+$ and $\Lambda_c(2940)^+$ decaying to $\Lambda_c^+\eta$ and $pD^0$ relative to $\Sigma_c(2455)\pi$

Author

Belle Collaboration, Li, S. X., Shen, C. P., Adachi, I., Ahn, J. K., Aihara, H., Asner, D. M., Atmacan, H., Aushev, T., Ayad, R., Banerjee, Sw., Belous, K., Bennett, J., Bessner, M., Bilka, T., Biswas, D., Bodrov, D., Bozek, A., Bračko, M., Branchini, P., Browder, T. E., Budano, A., Campajola, M., Chang, M. -C., Cheon, B. G., Chilikin, K., Cho, H. E., Cho, K., Choi, S. -K., Choi, Y., Choudhury, S., Dash, N., De Nardo, G., De Pietro, G., Dhamija, R., Dingfelder, J., Doležal, Z., Dong, T. V., Dubey, S., Ecker, P., Ferber, T., Fulsom, B. G., Gaur, V., Garmash, A., Goldenzweig, P., Graziani, E., Grube, B., Guan, Y., Gudkova, K., Hadjivasiliou, C., Hsu, C. -L., Ipsita, N., Itoh, R., Iwasaki, M., Jacobs, W. W., Ji, Q. P., Jia, S., Jin, Y., Joo, K. K., Kiesling, C., Kim, D. Y., Kim, Y. J., Kinoshita, K., Kodyš, P., Korobov, A., Korpar, S., Kovalenko, E., Križan, P., Krokovny, P., Kuhr, T., Kumar, R., Kumara, K., Kwon, Y. -J., Li, L. K., Li, Y., Li, Y. B., Liventsev, D., Masuda, M., Maurya, S. K., Meier, F., Merola, M., Miyabayashi, K., Mizuk, R., Mussa, R., Nakano, T., Nakao, M., Natochii, A., Nayak, M., Nishida, S., Pakhlov, P., Pakhlova, G., Pardi, S., Park, J., Park, S. -H., Patra, S., Paul, S., Pedlar, T. K., Pestotnik, R., Piilonen, L. E., Podobnik, T., Prencipe, E., Prim, M. T., Russo, G., Sandilya, S., Savinov, V., Schnell, G., Schwanda, C., Seino, Y., Senyo, K., Shiu, J. -G., Solovieva, E., Starič, M., Sumihama, M., Takizawa, M., Tamponi, U., Tanida, K., Tenchini, F., Uchida, M., Uglov, T., Uno, S., Wang, E., Won, E., Yabsley, B. D., Yan, W., Yelton, J., Yin, J. H., Yuan, L., and Zhilich, V.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

We search for excited charmed baryons in the $\Lambda_c^+\eta$ system using a data sample corresponding to an integrated luminosity of 980 $\rm fb^{-1}$. The data were collected by the Belle detector at the KEKB $e^{+}$$e^{-}$ asymmetric-energy collider. No significant signals are found in the $\Lambda_c^+\eta$ mass spectrum, including the known $\Lambda_c(2880)^+$ and $\Lambda_c(2940)^+$. Clear $\Lambda_c(2880)^+$ and $\Lambda_c(2940)^+$ signals are observed in the $pD^0$ mass spectrum. We set upper limits at 90\% credibility level on ratios of branching fractions of $\Lambda_c(2880)^+$ and $\Lambda_c(2940)^+$ decaying to $\Lambda_c^+\eta$ relative to $\Sigma_c(2455)\pi$ of $<0.13$ for the $\Lambda_c(2880)^+$ and $<1.11$ for the $\Lambda_c(2940)^+$. We measure ratios of branching fractions of $\Lambda_c(2880)^+$ and $\Lambda_c(2940)^+$ decaying to $pD^0$ relative to $\Sigma_c(2455)\pi$ of $0.75 \pm 0.03(\text{stat.}) \pm 0.07(\text{syst.})$ for the $\Lambda_c(2880)^+$ and $3.59 \pm 0.21(\text{stat.}) \pm 0.56(\text{syst.})$ for the $\Lambda_c(2940)^+$., Comment: 10 pages, 4 figures, accepted for publication as a Regular Article in Physical Review D

Published
2024
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20. Combating Intracellular Pathogens with Nanohybrid-Facilitated Antibiotic Delivery

Author

Bose RJC, Tharmalingam N, Choi Y, Madheswaran T, Paulmurugan R, McCarthy JR, Lee SH, and Park H

Subjects
nanohybrids, intracellular bacterial infection, mycobacterium smegmatis, staphylococcus aureus, doxycycline, vancomycin, Medicine (General), R5-920
Abstract

Rajendran JC Bose,1– 4,* Nagendran Tharmalingam,5,* Yonghyun Choi,1 Thiagarajan Madheswaran,6 Ramasamy Paulmurugan,2,3 Jason R McCarthy,4 Soo-Hong Lee,7 Hansoo Park1 1School of Integrative Engineering, Chung-Ang University, Seoul, South Korea; 2Molecular Imaging Program at Stanford (MIPS), Department of Radiology, School of Medicine, Stanford University, Stanford, CA 94305-5427, USA; 3Canary Center at Stanford for Cancer Early Detection, Department of Radiology, School of Medicine, Stanford University, Stanford, CA 94305-5427, USA; 4Masonic Medical Research Institute, Utica, NY, USA; 5Infectious Diseases Division, Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, RI 02903, USA; 6Department of Pharmaceutical Technology, School of Pharmacy, International Medical University, Kuala Lumpur 57000, Malaysia; 7Department of Medical Biotechnology, Dongguk University, Seoul, Gyeonggi-do, South Korea*These authors contributed equally to this workCorrespondence: Soo-Hong Lee Department of Medical BiotechnologyDongguk University, Seoul, Gyeonggi-do, South KoreaTel +82-31-961-5153Email soohong@dongguk.eduHansoo ParkSchool of Integrative Engineering, Chung-Ang University, Seoul, South KoreaTel +82 2-820-5804Email heyshoo@cau.ac.krBackground: Lipid polymer hybrid nanoparticles (LPHNPs) have been widely investigated in drug and gene delivery as well as in medical imaging. A knowledge of lipid-based surface engineering and its effects on how the physicochemical properties of LPHNPs affect the cell–nanoparticle interactions, and consequently how it influences the cytological response, is in high demand.Methods: Herein, we have engineered antibiotic-loaded (doxycycline or vancomycin) LPHNPs with cationic and zwitterionic lipids and examined the effects on their physicochemical characteristics (size and charge), antibiotic entrapment efficiency, and the in vitro intracellular bacterial killing efficiency against Mycobacterium smegmatis or Staphylococcus aureus infected macrophages.Results: The incorporation of cationic or zwitterionic lipids in the LPHNP formulation resulted in a size reduction in LPHNPs formulations and shifted the surface charge of bare NPs towards positive or neutral values. Also observed were influences on the drug incorporation efficiency and modulation of the drug release from the biodegradable polymeric core. The therapeutic efficacy of LPHNPs loaded with vancomycin was improved as its minimum inhibitory concentration (MIC) (2 μg/mL) versus free vancomycin (4 μg/mL). Importantly, our results show a direct relationship between the cationic surface nature of LPHNPs and its intracellular bacterial killing efficiency as the cationic doxycycline or vancomycin loaded LPHNPs reduced 4 or 3 log CFU respectively versus the untreated controls.Conclusion: In our study, modulation of surface charge in the nanomaterial formulation increased macrophage uptake and intracellular bacterial killing efficiency of LPHNPs loaded with antibiotics, suggesting alternate way for optimizing their use in biomedical applications.Keywords: nanohybrids, intracellular bacterial infection, Mycobacterium smegmatis, Staphylococcus aureus, doxycycline, vancomycin

Published
2020

21. ADAM17 Genetic Variants and the Response of TNF-α Inhibitor in Rheumatoid Arthritis Patients

Author

Kim HJ, Trinh NT, Choi Y, Kim W, Min KH, Kang SO, Kim JH, Kim HA, Jung JY, Choi IA, and Lee KE

Subjects
rheumatoid arthritis, tnf-α inhibitor, adam17, single nucleotide polymorphism, Therapeutics. Pharmacology, RM1-950
Abstract

Hyun Jeong Kim, 1,* Nga Thi Trinh, 1,* Yunjeong Choi, 1 Woorim Kim, 1 Kyung Hyun Min, 1 Sang Oh Kang, 1 Joo Hee Kim, 2 Hyoun-Ah Kim, 3 Ju-Yang Jung, 3 In Ah Choi, 4 Kyung Eun Lee 1 1College of Pharmacy, Chungbuk National University, Cheongju-si, Republic of Korea; 2College of Pharmacy, Ajou University, Suwon, Republic of Korea; 3Department of Rheumatology, Ajou University School of Medicine, Suwon, Republic of Korea; 4Division of Rheumatology, Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, Republic of Korea*These authors contributed equally to this workCorrespondence: Kyung Eun LeeCollege of Pharmacy, Chungbuk National University, 660-1 Yeonje-ri, Osong-eup, Heungdeok-gu, Cheongju-si 28160, Republic of KoreaTel +82 43 261 3590Fax +82 43 268 2732Email kaylee@cbnu.ac.krPurpose: TNF-α is a transmembrane protein which requires cleavage by ADAM17 in order to act systemically. The activation of ADAM17 to generate soluble TNF‑α results in an increased inflammatory activity. We hypothesized that variants spanning the ADAM17 gene contribute towards the observed variation in patient response defined by the number of changes in TNF‑α inhibitors.Patients and Methods: Seven single-nucleotide polymorphisms (SNPs) of ADAM17 in 63 patients with rheumatoid arthritis who received TNF-α inhibitors were analyzed: rs57467365, rs62117540, rs117645314, rs6432013, rs532704607, rs117179141, and rs12692386. Univariate and multivariate regression analysis were employed to investigate the independent predictable factors for changes in TNF-α inhibitors.Results: ADAM17 rs117645314 and rs117179141 showed significant association with the number of changes in TNF-α inhibitors. Patients with GA in rs117645314 and AT in rs117179141 had significantly higher chance of two or more changes of TNF-α inhibitors than those with wild homozygous alleles. Multivariate analysis showed that rs117179141 explained 5.7% of the 23.8% variability in TNF-α inhibitor response.Conclusion: This study showed that the number of changes in TNF-α inhibitor is associated with ADAM17 SNPs.Keywords: rheumatoid arthritis, TNF-α inhibitor, ADAM17, single-nucleotide polymorphism

Published
2020

22. Search for Two-Body $B$ Meson Decays to $\Lambda^{0}$ and $\Omega^{(*)0}_{c}$

Author

Belle Collaboration, Savinov, V., Adachi, I., Ahn, J. K., Aihara, H., Asner, D. M., Atmacan, H., Ayad, R., Banerjee, Sw., Bennett, J., Bessner, M., Bhardwaj, V., Biswas, D., Bobrov, A., Bodrov, D., Borah, J., Bračko, M., Branchini, P., Browder, T. E., Budano, A., Červenkov, D., Chang, M. -C., Chang, P., Cheon, B. G., Cho, K., Choi, S. -K., Choi, Y., Choudhury, S., Dash, N., De Nardo, G., De Pietro, G., Dhamija, R., Di Capua, F., Dingfelder, J., Doležal, Z., Dubey, S., Ecker, P., Epifanov, D., Ferlewicz, D., Fulsom, B. G., Gaur, V., Giri, A., Goldenzweig, P., Graziani, E., Gu, T., Guan, Y., Gudkova, K., Hadjivasiliou, C., Hayashii, H., Hazra, S., Hedges, M. T., Hou, W. -S., Inami, K., Ipsita, N., Ishikawa, A., Itoh, R., Iwasaki, M., Jacobs, W. W., Jin, Y., Kalita, D., Kim, C. H., Kim, D. Y., Kim, K. -H., Kim, Y. -K., Kinoshita, K., Kodyš, P., Korobov, A., Korpar, S., Kovalenko, E., Križan, P., Krokovny, P., Kuhr, T., Kumar, R., Kumita, T., Kuzmin, A., Kwon, Y. -J., Lai, Y. -T., Lam, T., Lange, J. S., Li, L. K., Li, Y., Li, Y. B., Gioi, L. Li, Libby, J., Liventsev, D., Luo, T., Ma, Y., Masuda, M., Matsuda, T., Maurya, S. K., Meier, F., Merola, M., Nakamura, I., Nakao, M., Natkaniec, Z., Nayak, L., Nayak, M., Nishida, S., Ogawa, S., Ono, H., Pakhlov, P., Pakhlova, G., Pardi, S., Park, H., Park, J., Park, S. -H., Passeri, A., Patra, S., Pestotnik, R., Piilonen, L. E., Podobnik, T., Prencipe, E., Prim, M. T., Russo, G., Sandilya, S., Santelj, L., Schnell, G., Schwanda, C., Seino, Y., Senyo, K., Shan, W., Sharma, C., Shiu, J. -G., Solovieva, E., Starič, M., Sumihama, M., Takizawa, M., Tamponi, U., Tanida, K., Tenchini, F., Tiwary, R., Trabelsi, K., Uchida, M., Unno, Y., Uno, S., Varvell, K. E., Wang, E., Watanuki, S., Won, E., Xu, X., Yabsley, B. D., Yan, W., Yin, J. H., Yuan, C. Z., Yuan, L., Yusa, Y., Zhang, Z. P., Zhilich, V., and Zhukova, V.

Subjects
High Energy Physics - Experiment
Abstract

We report the results of the first search for Standard Model and baryon-number-violating two-body decays of the neutral $B$ mesons to $\Lambda^{0}$ and $\Omega^{(*)0}_c$ using 711~${\rm fb^{-1}}$ of data collected at the $\Upsilon(4S)$ resonance with the Belle detector at the KEKB asymmetric-energy $e^+ e^-$ collider. We observe no evidence of signal from any such decays and set 95\% confidence-level upper limits on the products of $B^0$ and $\bar{B}^0$ branching fractions for these two-body decays with $\mathcal{B}(\Omega_{c}^{0} \to \pi^+ \Omega^-)$ in the range between 9.5~$\times 10^{-8}$ and 31.2~$\times 10^{-8}$., Comment: 6 pages, 2 figures, submitted to PRD(L)

Published
2024

23. Determination of the CKM angle $\phi_{3}$ from a combination of Belle and Belle II results

Author

Belle, Collaborations, Belle II, Adachi, I., Aggarwal, L., Aihara, H., Akopov, N., Aloisio, A., Said, S. Al, Ky, N. Anh, Asner, D. M., Atmacan, H., Aushev, V., Aversano, M., Ayad, R., Babu, V., Bae, H., Bahinipati, S., Bambade, P., Banerjee, Sw., Bansal, S., Barrett, M., Baudot, J., Baur, A., Beaubien, A., Becherer, F., Becker, J., Belous, K., Bennett, J. V., Bernlochner, F. U., Bertacchi, V., Bertemes, M., Bertholet, E., Bessner, M., Bettarini, S., Bhuyan, B., Bianchi, F., Bierwirth, L., Bilka, T., Bilokin, S., Biswas, D., Bobrov, A., Bodrov, D., Bolz, A., Bondar, A., Bozek, A., Bračko, M., Branchini, P., Briere, R. A., Browder, T. E., Budano, A., Bussino, S., Campajola, M., Cao, L., Casarosa, G., Cecchi, C., Cerasoli, J., Chang, M. -C., Chang, P., Cheaib, R., Cheema, P., Cheon, B. G., Chilikin, K., Chirapatpimol, K., Cho, H. -E., Cho, K., Choi, S. -K., Choi, Y., Choudhury, S., Corona, L., Das, S., Dattola, F., De La Cruz-Burelo, E., De La Motte, S. A., de Marino, G., De Nardo, G., De Nuccio, M., De Pietro, G., de Sangro, R., Destefanis, M., Dhamija, R., Di Canto, A., Di Capua, F., Dingfelder, J., Doležal, Z., Dong, T. V., Dorigo, M., Dort, K., Dossett, D., Dreyer, S., Dubey, S., Dujany, G., Ecker, P., Eliachevitch, M., Epifanov, D., Feichtinger, P., Ferber, T., Ferlewicz, D., Fillinger, T., Finocchiaro, G., Fodor, A., Forti, F., Frey, A., Fulsom, B. G., Gabrielli, A., Ganiev, E., Garcia-Hernandez, M., Garg, R., Gaudino, G., Gaur, V., Gaz, A., Gellrich, A., Ghevondyan, G., Ghosh, D., Ghumaryan, H., Giakoustidis, G., Giordano, R., Giri, A., Gobbo, B., Godang, R., Gogota, O., Goldenzweig, P., Gradl, W., Grammatico, T., Granderath, S., Graziani, E., Greenwald, D., Gruberová, Z., Gu, T., Guan, Y., Gudkova, K., Halder, S., Han, Y., Hara, T., Hayashii, H., Hazra, S., Hedges, M. T., Heidelbach, A., de la Cruz, I. Heredia, Villanueva, M. Hernández, Higuchi, T., Hoek, M., Hohmann, M., Horak, P., Hsu, C. -L., Humair, T., Iijima, T., Inami, K., Ipsita, N., Ishikawa, A., Itoh, R., Iwasaki, M., Jackson, P., Jacobs, W. W., Jang, E. -J., Ji, Q. P., Jia, S., Jin, Y., Junkerkalefeld, H., Kalita, D., Kaliyar, A. B., Kandra, J., Kawasaki, T., Keil, F., Kiesling, C., Kim, C. -H., Kim, D. Y., Kim, K. -H., Kim, Y. -K., Kindo, H., Kinoshita, K., Kodyš, P., Koga, T., Kohani, S., Kojima, K., Korobov, A., Korpar, S., Kovalenko, E., Kowalewski, R., Kraetzschmar, T. M. G., Križan, P., Krokovny, P., Kuhr, T., Kumar, J., Kumar, M., Kumar, R., Kumara, K., Kunigo, T., Kuzmin, A., Kwon, Y. -J., Lacaprara, S., Lai, Y. -T., Lam, T., Lanceri, L., Lange, J. S., Laurenza, M., Lee, M. J., Levit, D., Lewis, P. M., Li, C., Li, L. K., Li, Y., Li, Y. B., Libby, J., Liu, M. H., Liu, Q. Y., Liu, Z. Q., Liventsev, D., Longo, S., Lueck, T., Lyu, C., Ma, Y., Maggiora, M., Maharana, S. P., Maiti, R., Maity, S., Mancinelli, G., Manfredi, R., Manoni, E., Mantovano, M., Marcantonio, D., Marcello, S., Marinas, C., Martel, L., Martellini, C., Martini, A., Martinov, T., Massaccesi, L., Masuda, M., Matvienko, D., Maurya, S. K., McKenna, J. A., Mehta, R., Meier, F., Merola, M., Metzner, F., Miller, C., Mirra, M., Miyabayashi, K., Miyake, H., Mohanty, G. B., Molina-Gonzalez, N., Mondal, S., Moneta, S., Moser, H. -G., Mrvar, M., Mussa, R., Nakamura, I., Nakamura, K. R., Nakao, M., Nakazawa, Y., Charan, A. Narimani, Naruki, M., Narwal, D., Natkaniec, Z., Natochii, A., Nayak, L., Nayak, M., Nazaryan, G., Neu, M., Niebuhr, C., Nishida, S., Ogawa, S., Onishchuk, Y., Ono, H., Oskin, P., Otani, F., Pakhlov, P., Pakhlova, G., Panta, A., Pardi, S., Parham, K., Park, H., Park, S. -H., Passeri, A., Patra, S., Paul, S., Pedlar, T. K., Peschke, R., Pestotnik, R., Piccolo, M., Piilonen, L. E., Angioni, G. Pinna, Podesta-Lerma, P. L. M., Podobnik, T., Pokharel, S., Praz, C., Prell, S., Prencipe, E., Prim, M. T., Purwar, H., Rados, P., Raeuber, G., Raiz, S., Rauls, N., Reif, M., Reiter, S., Remnev, M., Ripp-Baudot, I., Rizzo, G., Robertson, S. H., Roehrken, M., Roney, J. M., Rostomyan, A., Rout, N., Russo, G., Sanders, D. A., Sandilya, S., Santelj, L., Sato, Y., Savinov, V., Scavino, B., Schmitt, C., Schnell, G., Schwanda, C., Schwickardi, M., Seino, Y., Selce, A., Senyo, K., Serrano, J., Sevior, M. E., Sfienti, C., Shan, W., Shi, X. D., Shillington, T., Shimasaki, T., Shiu, J. -G., Shtol, D., Shwartz, B., Sibidanov, A., Simon, F., Singh, J. B., Skorupa, J., Sobie, R. J., Sobotzik, M., Soffer, A., Sokolov, A., Solovieva, E., Spataro, S., Spruck, B., Starič, M., Stavroulakis, P., Stefkova, S., Stroili, R., Sumihama, M., Sumisawa, K., Sutcliffe, W., Suwonjandee, N., Takizawa, M., Tamponi, U., Tanida, K., Tenchini, F., Tittel, O., Tiwary, R., Tonelli, D., Torassa, E., Trabelsi, K., Tsaklidis, I., Uchida, M., Ueda, I., Uematsu, Y., Uglov, T., Unger, K., Unno, Y., Uno, K., Uno, S., Urquijo, P., Ushiroda, Y., Vahsen, S. E., van Tonder, R., Varvell, K. E., Veronesi, M., Vinokurova, A., Vismaya, V. S., Vitale, L., Vobbilisetti, V., Volpe, R., Wach, B., Wakai, M., Wallner, S., Wang, E., Wang, M. -Z., Wang, X. L., Wang, Z., Warburton, A., Watanuki, S., Wessel, C., Won, E., Xu, X. P., Yabsley, B. D., Yamada, S., Yan, W., Yang, S. B., Yelton, J., Yin, J. H., Yoshihara, K., Yuan, C. Z., Zhang, B., Zhang, Y., Zhilich, V., Zhou, Q. D., and Zhukova, V. I.

Subjects
High Energy Physics - Experiment
Abstract

We report a determination of the CKM angle $\phi_{3}$, also known as $\gamma$, from a combination of measurements using samples of up to 711~fb$^{-1}$ from the Belle experiment and up to 362~fb$^{-1}$ from the Belle II experiment. We combine results from analyses of $B^+\to DK^+, B^+\to D\pi^+$, and $B^+ \to D^{*}K^+$ decays, where $D$ is an admixture of $D^0$ and $\overline{D}{}^{0}$ mesons, in a likelihood fit to obtain $\phi_{3} = (78.6^{+7.2}_{-7.3})^{\circ}$. We also briefly discuss the interpretation of this result., Comment: 31 pages, 4 figures

Published
2024

24. Search for Rare $b \to d\ell^+\ell^-$ Transitions at Belle

Author

Belle, Collaborations, Belle II, Adachi, I., Aggarwal, L., Aihara, H., Akopov, N., Aloisio, A., Said, S. Al, Asner, D. M., Atmacan, H., Aushev, V., Aversano, M., Ayad, R., Babu, V., Bae, H., Bahinipati, S., Bambade, P., Banerjee, Sw., Bansal, S., Barrett, M., Baudot, J., Beaubien, A., Becherer, F., Becker, J., Belous, K., Bennett, J. V., Bernlochner, F. U., Bertacchi, V., Bertemes, M., Bertholet, E., Bessner, M., Bettarini, S., Bianchi, F., Bierwirth, L., Bilka, T., Biswas, D., Bobrov, A., Bodrov, D., Bolz, A., Borah, J., Bozek, A., Bračko, M., Branchini, P., Briere, R. A., Browder, T. E., Budano, A., Bussino, S., Campajola, M., Cao, L., Casarosa, G., Cecchi, C., Cerasoli, J., Chang, M. -C., Chang, P., Cheaib, R., Cheema, P., Chen, C., Cheon, B. G., Chilikin, K., Chirapatpimol, K., Cho, H. -E., Cho, K., Cho, S. -J., Choi, S. -K., Choi, Y., Choudhury, S., Cochran, J., Corona, L., Das, S., Dattola, F., De La Cruz-Burelo, E., De La Motte, S. A., de Marino, G., De Nardo, G., De Pietro, G., de Sangro, R., Destefanis, M., Dey, S., Dhamija, R., Di Capua, F., Dingfelder, J., Doležal, Z., Dong, T. V., Dorigo, M., Dort, K., Dossett, D., Dreyer, S., Dubey, S., Dugic, K., Dujany, G., Ecker, P., Epifanov, D., Feichtinger, P., Ferber, T., Ferlewicz, D., Fillinger, T., Finck, C., Finocchiaro, G., Fodor, A., Forti, F., Fulsom, B. G., Gabrielli, A., Ganiev, E., Garcia-Hernandez, M., Garg, R., Gaudino, G., Gaur, V., Gellrich, A., Ghevondyan, G., Ghosh, D., Ghumaryan, H., Giakoustidis, G., Giordano, R., Giri, A., Glazov, A., Gobbo, B., Godang, R., Gogota, O., Goldenzweig, P., Grammatico, T., Granderath, S., Graziani, E., Greenwald, D., Gruberová, Z., Gu, T., Guan, Y., Gudkova, K., Han, Y., Hara, T., Hayasaka, K., Hayashii, H., Hazra, S., Hedges, M. T., Heidelbach, A., de la Cruz, I. Heredia, Villanueva, M. Hernández, Higuchi, T., Hoek, M., Hohmann, M., Horak, P., Hsu, C. -L., Humair, T., Iijima, T., Inami, K., Inguglia, G., Ipsita, N., Ishikawa, A., Itoh, R., Iwasaki, M., Jacobs, W. W., Jang, E. -J., Ji, Q. P., Jia, S., Jin, Y., Junkerkalefeld, H., Kalita, D., Kaliyar, A. B., Kandra, J., Kang, S., Karyan, G., Kawasaki, T., Keil, F., Kiesling, C., Kim, C. -H., Kim, D. Y., Kim, K. -H., Kim, Y. -K., Kinoshita, K., Kodyš, P., Koga, T., Kohani, S., Kojima, K., Korobov, A., Korpar, S., Kovalenko, E., Kowalewski, R., Kraetzschmar, T. M. G., Križan, P., Krokovny, P., Kuhr, T., Kulii, Y., Kumar, J., Kumar, M., Kumara, K., Kunigo, T., Kuzmin, A., Kwon, Y. -J., Lacaprara, S., Lai, Y. -T., Lalwani, K., Lam, T., Lanceri, L., Lange, J. S., Laurenza, M., Lautenbach, K., Leboucher, R., Diberder, F. R. Le, Lee, M. J., Leo, P., Levit, D., Lewis, P. M., Li, L. K., Li, Y., Li, Y. B., Libby, J., Liu, Q. Y., Liu, Y., Liu, Z. Q., Liventsev, D., Longo, S., Lueck, T., Luo, T., Lyu, C., Ma, Y., Maggiora, M., Maharana, S. P., Maiti, R., Maity, S., Mancinelli, G., Manfredi, R., Manoni, E., Mantovano, M., Marcantonio, D., Marinas, C., Martellini, C., Martinov, T., Massaccesi, L., Masuda, M., Matvienko, D., Maurya, S. K., McKenna, J. A., Mehta, R., Meier, F., Merola, M., Metzner, F., Miller, C., Mirra, M., Mitra, S., Miyabayashi, K., Miyake, H., Mizuk, R., Mohanty, G. B., Moneta, S., Moser, H. -G., Mrvar, M., Mussa, R., Nakamura, I., Nakamura, K. R., Nakao, M., Nakazawa, Y., Charan, A. Narimani, Naruki, M., Natkaniec, Z., Natochii, A., Nayak, L., Nayak, M., Nazaryan, G., Neu, M., Ninkovic, J., Nishida, S., Ogawa, S., Onishchuk, Y., Ono, H., Otani, F., Pakhlova, G., Panta, A., Pardi, S., Parham, K., Park, S. -H., Paschen, B., Passeri, A., Patra, S., Pedlar, T. K., Peschke, R., Pestotnik, R., Piilonen, L. E., Podesta-Lerma, P. L. M., Podobnik, T., Pokharel, S., Praz, C., Prell, S., Prencipe, E., Prim, M. T., Purwar, H., Rados, P., Raeuber, G., Raiz, S., Rauls, N., Reif, M., Reiter, S., Remnev, M., Ripp-Baudot, I., Rizzo, G., Robertson, S. H., Roehrken, M., Roney, J. M., Rostomyan, A., Rout, N., Russo, G., Sanders, D. A., Sandilya, S., Santelj, L., Sato, Y., Savinov, V., Scavino, B., Schmitt, C., Schnell, G., Schwanda, C., Schwickardi, M., Seino, Y., Selce, A., Senyo, K., Sevior, M. E., Sfienti, C., Shan, W., Shi, X. D., Shillington, T., Shiu, J. -G., Shtol, D., Shwartz, B., Sibidanov, A., Simon, F., Singh, J. B., Skorupa, J., Sobie, R. J., Sobotzik, M., Soffer, A., Sokolov, A., Solovieva, E., Spataro, S., Spruck, B., Starič, M., Stavroulakis, P., Stefkova, S., Stroili, R., Sumihama, M., Sumisawa, K., Sutcliffe, W., Suwonjandee, N., Svidras, H., Takizawa, M., Tamponi, U., Tanida, K., Tenchini, F., Tittel, O., Tiwary, R., Torassa, E., Trabelsi, K., Tsaklidis, I., Uchida, M., Ueda, I., Uglov, T., Unger, K., Unno, Y., Uno, K., Uno, S., Urquijo, P., Ushiroda, Y., Vahsen, S. E., van Tonder, R., Varvell, K. E., Veronesi, M., Vinokurova, A., Vismaya, V. S., Vitale, L., Vobbilisetti, V., Volpe, R., Wakai, M., Wallner, S., Wang, E., Wang, M. -Z., Wang, X. L., Wang, Z., Warburton, A., Watanabe, M., Watanuki, S., Wessel, C., Won, E., Xu, X. P., Yabsley, B. D., Yamada, S., Yan, W., Yang, S. B., Yelton, J., Yin, J. H., Yoshihara, K., Yuan, C. Z., Zani, L., Zeng, F., Zhang, B., Zhang, Y., Zhilich, V., Zhou, Q. D., Zhukova, V. I., and Žlebčík, R.

Subjects
High Energy Physics - Experiment
Abstract

We present the results of a search for the $b \to d\ell^+\ell^-$ flavor-changing neutral-current rare decays $B^{+, 0} \to (\eta, \omega, \pi^{+,0}, \rho^{+, 0}) e^+e^-$ and $B^{+, 0} \to (\eta, \omega, \pi^{0}, \rho^{+}) \mu^+\mu^-$ using a $711$ fb$^{-1}$ data sample that contains $772 \times 10^{6}$ $B\overline{B}$ events. The data were collected at the $\Upsilon(4S)$ resonance with the Belle detector at the KEKB asymmetric-energy $e^+e^-$ collider. We find no evidence for signal and set upper limits on branching fractions at the $90\%$ confidence level in the range $(3.8 - 47) \times 10^{-8}$ depending on the decay channel. The obtained limits are the world's best results. This is the first search for the channels $B^{+, 0} \to (\omega, \rho^{+,0}) e^+e^-$ and $B^{+, 0} \to (\omega, \rho^{+})\mu^+\mu^-$., Comment: 7 pages, 12 figures

Published
2024
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25. Angular analysis of $B \to K^* e^+ e^-$ in the low-$q^2$ region with new electron identification at Belle

Author

Belle Collaboration, Ferlewicz, D., Urquijo, P., Adachi, I., Adamczyk, K., Aihara, H., Asner, D. M., Atmacan, H., Ayad, R., Babu, V., Banerjee, Sw., Behera, P., Belous, K., Bennett, J., Bessner, M., Bhardwaj, V., Bhuyan, B., Bilka, T., Biswas, D., Bodrov, D., Bračko, M., Branchini, P., Browder, T. E., Budano, A., Campajola, M., Cao, L., Červenkov, D., Chang, M. -C., Cheon, B. G., Chilikin, K., Cho, H. E., Cho, K., Choi, S. -K., Choi, Y., Choudhury, S., Das, S., Dash, N., de Marino, G., De Pietro, G., Dhamija, R., Di Capua, F., Dingfelder, J., Doležal, Z., Dong, T. V., Dubey, S., Ecker, P., Epifanov, D., Ferber, T., Fulsom, B. G., Gaur, V., Garmash, A., Giri, A., Goldenzweig, P., Graziani, E., Gu, T., Guan, Y., Gudkova, K., Hadjivasiliou, C., Hara, T., Hayasaka, K., Hayashii, H., Hazra, S., Hedges, M. T., Herrmann, D., Hou, W. -S., Hsu, C. -L., Iijima, T., Ishikawa, A., Itoh, R., Iwasaki, M., Jacobs, W. W., Jia, S., Jin, Y., Kaliyar, A. B., Kiesling, C., Kim, C. H., Kim, D. Y., Kim, K. -H., Kim, Y. -K., Kinoshita, K., Kodyš, P., Konno, T., Korobov, A., Korpar, S., Kou, E., Kovalenko, E., Križan, P., Krokovny, P., Kuhr, T., Kumar, R., Kumara, K., Kuzmin, A., Kwon, Y. -J., Lai, Y. -T., Lam, T., Lee, S. C., Levit, D., Lewis, P., Li, L. K., Li, Y. B., Gioi, L. Li, Libby, J., Liventsev, D., Ma, Y., Matvienko, D., Meier, F., Merola, M., Metzner, F., Miyabayashi, K., Mizuk, R., Mohanty, G. B., Nakamura, I., Nakao, M., Natochii, A., Nayak, L., Nishida, S., Ogawa, S., Ono, H., Pardi, S., Park, J., Passeri, A., Patra, S., Paul, S., Pedlar, T. K., Pestotnik, R., Piilonen, L. E., Podobnik, T., Prencipe, E., Prim, M. T., Rout, N., Russo, G., Sandilya, S., Savinov, V., Schnell, G., Schwanda, C., Seino, Y., Senyo, K., Sevior, M. E., Shan, W., Sharma, C., Shiu, J. -G., Shwartz, B., Solovieva, E., Starič, M., Sumihama, M., Takizawa, M., Tamponi, U., Tanida, K., Tenchini, F., Uchida, M., Unno, Y., Uno, S., Ushiroda, Y., Vahsen, S. E., Varvell, K. E., Wang, E., Wang, M. -Z., Watanuki, S., Won, E., Yabsley, B. D., Yan, W., Yang, S. B., Yelton, J., Yin, J. H., Yuan, C. Z., Yuan, L., Yusa, Y., Zhang, Z. P., Zhilich, V., and Zhukova, V.

Subjects
High Energy Physics - Experiment
Abstract

We perform an angular analysis of the $B\to K^* e^+ e^-$ decay for the dielectron mass squared, $q^2$, range of $0.0008$ to $1.1200 ~\text{GeV}^2 /c^4$ using the full Belle data set in the $K^{*0} \to K^+ \pi^-$ and $K^{*+} \to K_S^0 \pi^+$ channels, incorporating new methods of electron identification to improve the statistical power of the data set. This analysis is sensitive to contributions from right-handed currents from physics beyond the Standard Model by constraining the Wilson coefficients $\mathcal{C}_7^{(\prime)}$. We perform a fit to the $B\to K^* e^+ e^-$ differential decay rate and measure the imaginary component of the transversality amplitude to be $A_T^{\rm Im} = -1.27 \pm 0.52 \pm 0.12$, and the $K^*$ transverse asymmetry to be $A_T^{(2)} = 0.52 \pm 0.53 \pm 0.11$, with $F_L$ and $A_T^{\rm Re}$ fixed to the Standard Model values. The resulting constraints on the value of $\mathcal{C}_7^{\prime}$ are consistent with the Standard Model within a $2\sigma$ confidence interval., Comment: Accepted by PRD

Published
2024

26. Search for a pentaquark state decaying into $pJ/\psi$ in $\Upsilon(1,2S)$ inclusive decays at Belle

Author

Belle Collaboration, Dong, X., Zhang, H. Y., Wang, X. L., Adachi, I., Ahn, J. K., Aihara, H., Said, S. Al, Asner, D. M., Atmacan, H., Ayad, R., Bahinipati, S., Banerjee, Sw., Bessner, M., Bhardwaj, V., Biswas, D., Bodrov, D., Bozek, A., Bračko, M., Branchini, P., Browder, T. E., Budano, A., Campajola, M., Červenkov, D., Chang, M. -C., Chang, P., Cheon, B. G., Cho, H. E., Cho, K., Choi, S. -K., Choi, Y., Choudhury, S., Das, S., De Nardo, G., De Pietro, G., Dhamija, R., Di Capua, F., Dingfelder, J., Doležal, Z., Dong, T. V., Ecker, P., Epifanov, D., Ferber, T., Ferlewicz, D., Fulsom, B. G., Garg, R., Gaur, V., Giri, A., Goldenzweig, P., Graziani, E., Gu, T., Guan, Y., Gudkova, K., Hadjivasiliou, C., Hayashii, H., Hazra, S., Hedges, M. T., Hou, W. -S., Hsu, C. -L., Inami, K., Ipsita, N., Ishikawa, A., Itoh, R., Iwasaki, M., Jacobs, W. W., Jia, S., Jin, Y., Kalita, D., Kawasaki, T., Kim, D. Y., Kim, K. -H., Kim, Y. J., Kim, Y. -K., Kinoshita, K., Kodyš, P., Korobov, A., Korpar, S., Kovalenko, E., Križan, P., Krokovny, P., Kuhr, T., Kumar, R., Kumita, T., Kuzmin, A., Kwon, Y. -J., Lai, Y. -T., Lam, T., Lange, J. S., Levit, D., Li, L. K., Li, Y., Li, Y. B., Gioi, L. Li, Libby, J., Liventsev, D., Ma, Y., Masuda, M., Matsuda, T., Maurya, S. K., Meier, F., Merola, M., Metzner, F., Miyabayashi, K., Mussa, R., Nakamura, I., Nakano, T., Nakao, M., Natkaniec, Z., Natochii, A., Nayak, L., Nayak, M., Nishida, S., Ogawa, S., Ono, H., Pakhlova, G., Pardi, S., Park, H., Park, J., Park, S. -H., Passeri, A., Patra, S., Paul, S., Pestotnik, R., Piilonen, L. E., Podobnik, T., Prencipe, E., Prim, M. T., Russo, G., Sandilya, S., Savinov, V., Schnell, G., Schwanda, C., Seino, Y., Senyo, K., Sevior, M. E., Shan, W., Sharma, C., Shiu, J. -G., Singh, J. B., Solovieva, E., Starič, M., Takizawa, M., Tanida, K., Tenchini, F., Tiwary, R., Uchida, M., Unno, Y., Uno, S., Urquijo, P., Usov, Y., Vinokurova, A., Watanuki, S., Won, E., Yabsley, B. D., Yan, W., Yang, S. B., Yelton, J., Yin, J. H., Yook, Y., Yuan, C. Z., Yuan, L., Yusa, Y., Zhang, Z. P., and Zhilich, V.

Subjects
High Energy Physics - Experiment
Abstract

Using the data samples of 102 million $\Upsilon(1S)$ and 158 million $\Upsilon(2S)$ events collected by the Belle detector, we search for a pentaquark state in the $pJ/\psi$ final state from $\Upsilon(1,2S)$ inclusive decays. Here, the charge-conjugate $\bar{p}J/\psi$ is included. We observe clear $pJ/\psi$ production in $\Upsilon(1,2S)$ decays and measure the branching fractions to be $\mathcal{B}[\Upsilon(1S) \to pJ/\psi + anything] = [4.27 \pm 0.16(stat.) \pm 0.20(syst.)] \times 10^{-5}$ and $\mathcal{B}[\Upsilon(2S) \to pJ/\psi + anything] = [3.59 \pm 0.14(stat.) \pm 0.16(syst.)] \times 10^{-5}$. We also measure the cross section of inclusive $pJ/\psi$ production in $e^+e^-$ annihilation to be $\sigma(e^+e^- \to pJ/\psi + anything) = [57.5 \pm 2.1 (stat.) \pm 2.5(syst.)]$~fb at $\sqrt{s} = 10.52~\hbox{GeV}$ using an 89.5~fb$^{-1}$ continuum data sample. There is no significant $P_c(4312)^+$, $P_c(4440)^+$ or $P_c(4457)^+$ signal found in the $pJ/\psi$ final states in $\Upsilon(1,2S)$ inclusive decays. We determine the upper limits of $\mathcal{B}[\Upsilon(1,2S)\to P_c^{+} + anything] \cdot \mathcal{B}(P_c^{+}\to pJ/\psi)$ to be at the $10^{-6}$ level.

Published
2024

27. RISK FACTORS OF ANEMIA AMONG CHILDREN AGED 6-59 MONTHS IN MADAGASCAR

Author

Kim, Y., Choi, Y., Kim, C., Seo, E., and Kang, Y.

Subjects
Anemia in children -- Risk factors -- Diagnosis -- Distribution, Disease susceptibility -- Evaluation, Company distribution practices, Agricultural industry, Food/cooking/nutrition, Health
Abstract

While child anemia remains an uncontrolled health issue in developing and underdeveloped countries, the public health burden of child anemia is high in Madagascar. Using cross-sectional data from Madagascar Demographic and Health Survey 2021 (Madagascar DHS 2021), this study aims to examine the prevalence and risk factors of child anemia by region and socioeconomic status in the country. A total of 5,048 children aged 6-59 months with hemoglobin (Hb) concentration data were used for the study. First, the associations between child anemia (Hb< 11.0g/dl) and the household, parental, and child characteristics were tested by univariate logistic regression analysis. Variables with a p-value Key words: Anemia prevention, anemia control, Madagascar, child health, public health, INTRODUCTION Anemia is a deficiency in red blood cells, or hemoglobin, which results in a decreased oxygen-carrying capacity of blood to human body [1]. Anemia leads to serious impacts on [...]

Published
2024
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30. Status of the RAON heavy-ion accelerator

Author

Chung, Y. S., Kang, J., Kwon, M., Kwon, E., Kwon, J. W., Kim, G. D., Kim, D. G., Kim, M. S., Kim, S., Kim, Y., Kim, Y. H., Kim, Y., Kim, J. W., Kim, J., Kim, H., Kim, H. J., Kim, H., Do, H., Park, M. J., Park, B. S., Park, I., Park, H., Bae, S. Y., Baek, B. Y., Seo, C. S., Seol, K. T., Son, K. T., Son, C., Son, H. J., Shin, J. H., Ahn, Y., Yang, K. S., Woo, H. J., Yoo, J. H., Yoon, J., Lee, D. Y., Lee, M. K., Lee, S. -. G., Lee, Y. H., Lee, J. W., Lee, J., Lim, E. H., Jang, J. H., Jang, H. M., Jang, H., Jeon, D., Jeon, S., Jung, Y., Jung, H. C., Jo, K. H., Jo, H. C., Jo, Y. W., Cho, J. H., Joo, J. D., Jin, H., Choi, S., Choi, O., Choi, Y. J., Choi, J. W., Choi, C. J., Han, J., Heo, J. I., Hyun, M. O., Hong, I. S., Ki, T., Kim, D. M., Moon, S., Yoon, S., Lee, S., and Choi, H. S.

Published
2024
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31. Reversible Horner’s syndrome after cervical spinal cord stimulator implantation in a patient with complex regional pain syndrome

Author

Yang J, Choi Y, Park J, Jeong J, Lee B, Lee K, Lee J, and Choi R

Subjects
Spinal cord stimulator, Horner’s syndrome, Complex regional pain syndrome, Superior cervical ganglion block, Medicine (General), R5-920
Abstract

Jaeyoung Yang, Yusun Choi, Juyoung Park, Junhyug Jeong, Bousung Lee, Kwanghaeng Lee, Jaedo Lee, Rakmin Choi Department of Anesthesiology and Pain Medicine, Veterans Health Service Medical Center, Seoul, South Korea Abstract: We successfully performed cervical spinal cord stimulator (SCS) surgery in a 27-year-old man with complex regional pain syndrome to control intractable pain. The SCS trial was performed twice to adjust the SCS coverage region. After permanent implantation surgery, the patient developed Horner’s syndrome when the region near the C4 spinal dorsal root was stimulated. However, Horner’s syndrome disappeared after changing the stimulation leads. This case report suggests that cervical SCS can be associated with superior cervical ganglion stimulation. Keywords: spinal cord stimulator, Horner’s syndrome, complex regional pain syndrome, superior cervical ganglion block

Published
2018

32. Pharmacokinetic interaction between fimasartan and atorvastatin in healthy male volunteers

Author

Choi Y, Lee S, Jang IJ, and Yu KS

Subjects
Angiotensin receptor blocker (ARB), Atorvastatin, Drug interaction, Fimasartan, HMG-CoA inhibitor, Pharmacokinetics, Therapeutics. Pharmacology, RM1-950
Abstract

Yewon Choi, SeungHwan Lee, In-Jin Jang, Kyung-Sang Yu Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea Introduction: Major cardiovascular risk factors, including hypertension and dyslipidemia, are often comorbidities, frequently leading to concurrent prescription of angiotensin receptor blockers and 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins). The study’s objective was to evaluate the effect of coadministration of fimasartan and atorvastatin on their pharmacokinetics (PKs). Subjects and methods: In a randomized, open-label, three-period, six-sequence, crossover, multiple-dose study, 36 healthy subjects received 120 mg fimasartan, 40 mg atorvastatin, or both (based on their assigned sequence) once daily for 7 days in each period, with a 7-day washout between periods. Blood samples for the PK analysis of fimasartan, atorvastatin, and the 2-hydroxy atorvastatin metabolite were collected up to 48 h after the last dose. Results: The coadministration of fimasartan and atorvastatin was well tolerated and led to an increase in the peak concentration and area under the concentration–time curve at steady state of fimasartan by 2.18-fold (95% confidence interval [CI], 1.79–2.65) and 1.35-fold (95% CI, 1.26–1.43) and those of atorvastatin increased by 1.82-fold (95% CI, 1.51–2.18) and 1.12-fold (95% CI, 1.04–1.22), respectively. Conclusion: Coadministration increased the systemic exposures of fimasartan and atorvastatin, but the clinical significance of this finding needs to be evaluated with respect to exposure responses and clinical outcomes. Keywords: angiotensin receptor blocker, statin, HMG-CoA inhibitor, fixed dose combination, FDC

Published
2018

33. Effect of food on the pharmacokinetic characteristics of a single oral dose of LCB01-0371, a novel oxazolidinone antibiotic

Author

Sunwoo J, Kim YK, Choi Y, Yu KS, Nam H, Cho YL, Yoon S, and Chung JY

Subjects
food effect, pharmacokinetics, oxazolidinone, novel antibiotic, Therapeutics. Pharmacology, RM1-950
Abstract

Jung Sunwoo,1 Yu Kyong Kim,1 Yewon Choi,1 Kyung-Sang Yu,1 Heesook Nam,2 Young Lag Cho,2 Seonghae Yoon,3 Jae-Yong Chung3 1Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, 2LegoChem Biosciences, Inc., Daejeon, 3Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Bundang Hospital, Seongnam, Republic of Korea Background: LCB01-0371 is a novel oxazolidinone antibiotic that blocks protein production by binding to bacterial 23S ribosomes. This antibiotic is active against Gram-positive bacteria. This study aimed to evaluate the effect of food on the pharmacokinetics (PKs) of LCB01-0371 and evaluate its safety profile.Subjects and methods: A randomized, open-label, two-way crossover study was performed in 18 healthy Korean male subjects. All subjects received a single oral 800 mg dose of LCB01-0371 in each period under fed or fasting condition with a 7-day washout in between. The fed condition was defined as consumption of a meal of 800–1,000 kcal containing ~50% of fat content. Serial blood samples were collected over 24 h after dosing, and the PK parameters were calculated by noncompartment analysis. All available data of the subjects who received LCB01-0371 at least once were included in the safety data summaries.Results: In the fed condition, both the maximum plasma concentration (Cmax) and the total systemic exposure (area under the plasma concentration–time curve from time zero to the last observed time point [AUClast]) decreased by ~33% and 10%, respectively. The time to reach Cmax was delayed by ~1.25 h in the fed condition, whereas the mean elimination half-life remained similar in both conditions. In the fed/fasting condition, the geometric mean ratios and 90% CI of the Cmax and AUClast were 0.666 (0.470–0.945) and 0.897 (0.761–1.057), respectively. There were no drug-related adverse events (AEs) or serious AEs.Conclusion: Although the Tmax after a single oral 800 mg dose of LCB01-0371 was slightly delayed under the fed condition compared to the fasting condition, the total systemic exposure was similar under both conditions. Therefore, LCB01-0371 could be administered regardless of food intake. Keywords: antibiotic resistance, gram-positive bacteria, clinical trial

Published
2018

34. Pharmacokinetic characteristics of telaprevir in healthy Korean male subjects and comparisons with Japanese

Author

Choi Y, Yoon S, Matsumoto K, Ohta Y, Lee S, Yu KS, and Jang IJ

Subjects
Telaprevir, hepatitis C virus, pharmacokinetics, Therapeutics. Pharmacology, RM1-950
Abstract

Yewon Choi,1 Seonghae Yoon,1 Kyoko Matsumoto,2 Yoshiyasu Ohta,3 SeungHwan Lee,1 Kyung-Sang Yu,1 In-Jin Jang1 1Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea; 2Ikuyaku Integrated Value Development Division, Mitsubishi Tanabe Pharma Corporation, Osaka, Japan; 3Sohyaku Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Tokyo, Japan Introduction: Telaprevir, a reversible selective inhibitor of viral protease and a potential blocker of viral replication, is indicated for the treatment of hepatitis C virus genotype 1 infection. In this study, the pharmacokinetic profile, safety, and tolerability of telaprevir and the effect of food on telaprevir exposure were evaluated in healthy Korean subjects, and compared with data from a previous study in Japanese male subjects. Methods: The single ascending dose study was conducted in 3 dose-based groups (500, 750, and 1,250 mg, six subjects each) in a fasted state. In the multiple dose study, eight subjects in the fed state received 750 mg of telaprevir once on Day 1 and every 8 hours from Day 2 until the morning of Day 6. Serial blood samples for pharmacokinetic analysis were collected for up to 24 hours in the single ascending dose study and for 6 days in the multiple dose study. Individual pharmacokinetic parameters were calculated using a non-compartmental analysis method. Safety and tolerability profiles were evaluated throughout the study. Results: Following multiple administrations of telaprevir, maximum plasma concentrations (Cmax), area under the concentration–time curve (AUC0–8), and Ctrough (concentration at 8 h after drug administration) increased by ~2.41-fold. Compared to fasted state values, mean Cmax and AUC0–24 increased by 4.92- and 4.81-fold, respectively, after food intake. The Cmax and AUCinf of Korean subjects were 26%–34% higher than those of Japanese subjects; however, these differences were not clinically significant. All observed adverse events were mild and there was no discontinuation due to AEs. Conclusion: In conclusion, the telaprevir’s pharmacokinetic characteristics were similar in Korean and Japanese subjects. Telaprevir was well tolerated in a single dose of up to 1,250 mg and in multiple doses of 750 mg. Keywords: antiviral agents, hepatitis C virus, NS3/4A protease, ethnicity, pharmacokinetic profile

Published
2018

35. Search for a heavy neutral lepton that mixes predominantly with the tau neutrino

Author

Belle Collaboration, Nayak, M., Dey, S., Soffer, A., Adachi, I., Aihara, H., Said, S. Al, Asner, D. M., Atmacan, H., Ayad, R., Babu, V., Banerjee, Sw., Bauer, M., Behera, P., Belous, K., Bessner, M., Bhardwaj, V., Bhuyan, B., Bilka, T., Biswas, D., Bobrov, A., Bodrov, D., Bračko, M., Branchini, P., Browder, T. E., Budano, A., Campajola, M., Červenkov, D., Chang, M. -C., Cheon, B. G., Cho, H. E., Cho, K., Choi, Y., Choudhury, S., Das, S., De Nardo, G., De Pietro, G., Dhamija, R., Di Capua, F., Dingfelder, J., Doležal, Z., Dong, T. V., Dubey, S., Ecker, P., Epifanov, D., Ferber, T., Fogel, O., Fulsom, B. G., Gaur, V., Giri, A., Goldenzweig, P., Graziani, E., Gudkova, K., Hadjivasiliou, C., Halder, S., Hara, T., Hayasaka, K., Hayashii, H., Hazra, S., Hedges, M. T., Herrmann, D., Hou, W. -S., Hsu, C. -L., Inami, K., Ishikawa, A., Itoh, R., Iwasaki, M., Jacobs, W. W., Jia, S., Jin, Y., Kawasaki, T., Kiesling, C., Kim, C. H., Kim, D. Y., Kinoshita, K., Kodyš, P., Korobov, A., Korpar, S., Križan, P., Krokovny, P., Kuhr, T., Kumar, D., Kumar, R., Kuzmin, A., Kwon, Y. -J., Lai, Y. -T., Lam, T., Lange, J. S., Laurenza, M., Lee, S. C., Li, L. K., Li, Y. B., Gioi, L. Li, Libby, J., Lieret, K., Lin, Y. -R., Liventsev, D., Luo, T., Ma, Y., Masuda, M., Maurya, S. K., Meier, F., Merola, M., Miyabayashi, K., Mizuk, R., Mohanty, G. B., Mussa, R., Nakamura, I., Nakao, M., Natkaniec, Z., Natochii, A., Nayak, L., Nishida, S., Ogawa, S., Ono, H., Oskin, P., Pakhlov, P., Pakhlova, G., Pardi, S., Park, H., Park, J., Park, S. -H., Passeri, A., Patra, S., Paul, S., Pestotnik, R., Piilonen, L. E., Podobnik, T., Prencipe, E., Prim, M. T., Röhrken, M., Rostomyan, A., Rout, N., Russo, G., Sandilya, S., Santelj, L., Savinov, V., Schnell, G., Schwanda, C., Seino, Y., Senyo, K., Sevior, M. E., Shan, W., Sharma, C., Shen, C. P., Shiu, J. -G., Singh, J. B., Sokolov, A., Solovieva, E., Starič, M., Sumihama, M., Takizawa, M., Tanida, K., Tenchini, F., Unno, Y., Uno, S., Ushiroda, Y., Vahsen, S. E., Wang, M. -Z., Watanuki, S., Won, E., Yabsley, B. D., Yan, W., Yin, J. H., Yuan, L., Zhang, Z. P., Zhilich, V., and Zhukova, V.

Subjects
High Energy Physics - Experiment
Abstract

We report a search for a heavy neutral lepton (HNL) that mixes predominantly with $\nu_\tau$. The search utilizes data collected with the Belle detector at the KEKB asymmetric energy $e^+ e^-$ collider. The data sample was collected at and just below the center-of-mass energies of the $\Upsilon(4S)$ and $\Upsilon(5S)$ resonances and has an integrated luminosity of $915~\textrm{fb}^{-1}$, corresponding to $(836\pm 12)\times 10^6$ $e^+e^\to\tau^+\tau^-$ events. We search for production of the HNL (denoted $N$) in the decay $\tau^-\to \pi^- N$ followed by its decay via $N \to \mu^+\mu^- \nu_\tau$. The search focuses on the parameter-space region in which the HNL is long lived, so that the $\mu^+\mu^-$ originate from a common vertex that is significantly displaced from the collision point of the KEKB beams. Consistent with the expected background yield, one event is observed in the data sample after application of all the event-selection criteria. We report limits on the mixing parameter of the HNL with the $\tau$ neutrino as a function of the HNL mass., Comment: 10 pages, 5 figures

Published
2024
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36. Search for Baryon-Number-Violating Processes in $B^-$ Decays to the $\bar{\Xi}_{c}^{0} \bar{\Lambda}_{c}^{-}$ Final State

Author

Belle Collaboration, Gu, T., Savinov, V., Adachi, I., Aihara, H., Asner, D. M., Atmacan, H., Aushev, T., Ayad, R., Banerjee, Sw., Belous, K., Bennett, J., Bessner, M., Bhardwaj, V., Bhuyan, B., Biswas, D., Bobrov, A., Bodrov, D., Borah, J., Bozek, A., Bračko, M., Branchini, P., Browder, T. E., Budano, A., Campajola, M., Červenkov, D., Chang, M. -C., Chang, P., Cheon, B. G., Chilikin, K., Cho, K., Choi, S. -K., Choi, Y., Choudhury, S., Das, S., De Nardo, G., De Pietro, G., Dhamija, R., Di Capua, F., Dingfelder, J., Doležal, Z., Dong, T. V., Dubey, S., Ecker, P., Ferber, T., Ferlewicz, D., Fulsom, B. G., Gaur, V., Giri, A., Goldenzweig, P., Graziani, E., Guan, Y., Gudkova, K., Hadjivasiliou, C., Hayasaka, K., Hayashii, H., Hedges, M. T., Herrmann, D., Hou, W. -S., Hsu, C. -L., Ipsita, N., Ishikawa, A., Itoh, R., Iwasaki, M., Jacobs, W. W., Jia, S., Jin, Y., Joo, K. K., Kawasaki, T., Kiesling, C., Kim, C. H., Kim, D. Y., Kim, K. -H., Kim, Y. J., Kodyš, P., Korobov, A., Korpar, S., Kovalenko, E., Križan, P., Krokovny, P., Kuhr, T., Kumara, K., Kumita, T., Kwon, Y. -J., Lai, Y. -T., Lee, S. C., Levit, D., Li, L. K., Li, Y. B., Gioi, L. Li, Liventsev, D., Masuda, M., Matsuda, T., Maurya, S. K., Meier, F., Merola, M., Metzner, F., Miyabayashi, K., Mizuk, R., Mohanty, G. B., Mussa, R., Nakamura, I., Nakao, M., Natkaniec, Z., Natochii, A., Nayak, L., Nayak, M., Niiyama, M., Nishida, S., Ogawa, S., Pakhlova, G., Pardi, S., Park, H., Park, J., Park, S. -H., Passeri, A., Patra, S., Paul, S., Pedlar, T. K., Pestotnik, R., Piilonen, L. E., Podobnik, T., Prencipe, E., Prim, M. T., Röhrken, M., Russo, G., Sandilya, S., Santelj, L., Schnell, G., Schwanda, C., Seino, Y., Senyo, K., Sevior, M. E., Shan, W., Sharma, C., Shiu, J. -G., Solovieva, E., Starič, M., Takizawa, M., Tamponi, U., Tanida, K., Tenchini, F., Tiwary, R., Trabelsi, K., Uchida, M., Unno, Y., Uno, S., Usov, Y., Vahsen, S. E., Varvell, K. E., Vinokurova, A., Wang, E., Wang, M. -Z., Wang, X. L., Watanuki, S., Won, E., Xu, X., Yabsley, B. D., Yan, W., Yang, S. B., Yuan, L., Zhang, Z. P., Zhilich, V., and Zhukova, V.

Subjects
High Energy Physics - Experiment
Abstract

We report the results of the first search for $B^-$ decays to the $\bar{\Xi}_{c}^{0} \bar{\Lambda}_{c}^{-}$ final state using 711~${\rm fb^{-1}}$ of data collected at the $\Upsilon(4S)$ resonance with the Belle detector at the KEKB asymmetric-energy $e^+ e^-$ collider. The results are interpreted in terms of both direct baryon-number-violating $B^-$ decay and $\Xi_{c}^{0}-\bar{\Xi}_{c}^{0}$ oscillations which follow the Standard Model decay $B^- \to \Xi_{c}^{0} \bar{\Lambda}_{c}^{-}$. We observe no evidence for baryon number violation and set the 95\% confidence-level upper limits on the ratio of baryon-number-violating and Standard Model branching fractions ${\mathcal{B}(B^- \rightarrow \bar{\Xi}_{c}^{0} \bar{\Lambda}_{c}^{-})}/{\mathcal{B}(B^- \rightarrow \Xi_{c}^{0} \bar{\Lambda}_{c}^{-})}$ to be $< 2.7\%$ and on the $\Xi_{c}^{0} - \bar{\Xi}_{c}^{0}$ oscillation angular frequency $\omega$ to be $< 0.76\ \mathrm{ps}^{-1}$ (equivalent to $\tau_{\rm mix} > 1.3$~ps)., Comment: 7 pages, 2 figures, submitted to Phys. Rev. Lett

Published
2024

37. Measurements of the branching fraction, polarization, and $CP$ asymmetry for the decay $B^0\rightarrow \omega \omega$

Author

Belle Collaboration, Guan, Y., Schwartz, A. J., Kinoshita, K., Adachi, I., Aihara, H., Said, S. Al, Asner, D. M., Atmacan, H., Ayad, R., Bahinipati, S., Banerjee, Sw., Belous, K., Bennett, J., Bessner, M., Bhardwaj, V., Bhuyan, B., Biswas, D., Bobrov, A., Bodrov, D., Borah, J., Bozek, A., Bračko, M., Branchini, P., Budano, A., Campajola, M., Cao, L., Červenkov, D., Chang, M. -C., Chang, P., Cheon, B. G., Chilikin, K., Cho, H. E., Cho, K., Choi, S. -K., Choi, Y., Choudhury, S., Das, S., De Nardo, G., De Pietro, G., Dhamija, R., Di Capua, F., Dingfelder, J., Doležal, Z., Dong, T. V., Dubey, S., Ecker, P., Epifanov, D., Ferber, T., Ferlewicz, D., Fulsom, B. G., Gaur, V., Giri, A., Goldenzweig, P., Graziani, E., Gu, T., Gudkova, K., Hadjivasiliou, C., Hayasaka, K., Hayashii, H., Hazra, S., Hedges, M. T., Hou, W. -S., Hsu, C. -L., Ipsita, N., Ishikawa, A., Itoh, R., Iwasaki, M., Jacobs, W. W., Jia, S., Jin, Y., Joo, K. K., Kawasaki, T., Kim, C. H., Kim, D. Y., Kim, K. -H., Kim, Y. J., Kim, Y. -K., Kodyš, P., Korobov, A., Korpar, S., Kovalenko, E., Križan, P., Krokovny, P., Kuhr, T., Kumar, R., Kumara, K., Kumita, T., Kwon, Y. -J., Lai, Y. -T., Lee, S. C., Levit, D., Li, L. K., Li, Y., Li, Y. B., Gioi, L. Li, Libby, J., Liventsev, D., Luo, T., Masuda, M., Matsuda, T., Maurya, S. K., Meier, F., Merola, M., Metzner, F., Miyabayashi, K., Mizuk, R., Mohanty, G. B., Mussa, R., Nakamura, I., Nakao, M., Natkaniec, Z., Natochii, A., Nayak, L., Nayak, M., Niiyama, M., Nishida, S., Ogawa, S., Ono, H., Pakhlova, G., Pardi, S., Park, H., Park, J., Park, S. -H., Paul, S., Pestotnik, R., Piilonen, L. E., Podobnik, T., Prencipe, E., Prim, M. T., Röhrken, M., Russo, G., Sandilya, S., Santelj, L., Savinov, V., Schnell, G., Schwanda, C., Seino, Y., Senyo, K., Sevior, M. E., Shan, W., Shiu, J. -G., Solovieva, E., Starič, M., Sumisawa, K., Takizawa, M., Tamponi, U., Tanida, K., Tenchini, F., Tiwary, R., Trabelsi, K., Uchida, M., Unno, Y., Uno, S., Urquijo, P., Usov, Y., Vahsen, S. E., Varvell, K. E., Vinokurova, A., Wang, M. -Z., Watanuki, S., Won, E., Xu, X., Yabsley, B. D., Yan, W., Yook, Y., Yuan, L., Zhang, Z. P., Zhilich, V., and Zhukova, V.

Subjects
High Energy Physics - Experiment
Abstract

We present a measurement of $B^{0} \rightarrow \omega \omega$, a charmless decay into two vector mesons, using 772 $\times 10^6$ $B\overline{B}$ pairs collected with the Belle detector at the KEKB $e^+e^-$ collider. The decay is observed with a significance of 7.9 standard deviations. We measure a branching fraction $\mathcal{B} = (1.53 \pm 0.29 \pm 0.17) \times 10^{-6}$, a fraction of longitudinal polarization $f_L = 0.87 \pm 0.13 \pm 0.13$, and a time-integrated $CP$ asymmetry $A_{CP}$ = $-0.44 \pm 0.43 \pm 0.11$, where the first uncertainties listed are statistical and the second are systematic. This is the first observation of $B^{0} \rightarrow \omega \omega$, and the first measurements of $f_L$ and $A_{CP}$ for this decay., Comment: 7 pages, 1 figure, submitted to Phys. Rev. Lett

Published
2024

38. Technological developments and accelerator improvements for the FRIB beam power ramp-up

Author

Wei, J, Alleman, C, Ao, H, Arend, B, Barofsky, D, Beher, S, Bollen, G, Bultman, N, Casagrande, F, Chang, W, Choi, Y, Cogan, S, Cole, P, Compton, C, Cortesi, M, Curtin, J, Davidson, K, Di Carlo, S, Du, X, Elliott, K, Ewert, B, Facco, A, Fila, A, Fukushima, K, Ganni, V, Ganshyn, A, Ginter, T, Glasmacher, T, Gonzalez, A, Hao, Y, Hartung, W, Hasan, N, Hausmann, M, Holland, K, Hseuh, HC, Ikegami, M, Jager, D, Jones, S, Joseph, N, Kanemura, T, Kim, SH, Knowles, C, Konomi, T, Kortum, B, Kulkarni, N, Kwan, E, Lange, T, Larmann, M, Larter, T, Laturkar, K, LaVere, M, Laxdal, RE, LeTourneau, J, Li, Z-Y, Lidia, S, Machicoane, G, Magsig, C, Manwiller, P, Marti, F, Maruta, T, Metzgar, E, Miller, S, Momozaki, Y, Mugerian, M, Morris, D, Nesterenko, I, Nguyen, C, Ostroumov, P, Patil, M, Plastun, A, Popielarski, L, Portillo, M, Powers, A, Priller, J, Rao, X, Reaume, M, Rodriguez, S, Rogers, S, Saito, K, Sherrill, BM, Smith, MK, Song, J, Steiner, M, Stolz, A, Tarasov, O, Tousignant, B, Walker, R, Wang, X, Wenstrom, J, West, G, Witgen, K, Wright, M, Xu, T, Yamazaki, Y, Zhang, T, Zhao, Q, Zhao, S, Hurh, P, Prestemon, S, and Shen, T

Subjects
Nuclear and Plasma Physics, Engineering, Synchrotrons and Accelerators, Physical Sciences, Nuclear & Particles Physics, Physical sciences
Abstract

The Facility for Rare Isotope Beams (FRIB) began operation with 1 kW beam power for scientific users in May 2022 upon completion of 8 years of project construction. The ramp-up to the ultimate beam power of 400 kW, planned over a 6-year period, will enable the facility to reach its full potential for scientific discovery in isotope science and applications. In December 2023, a record-high beam power of 10.4 kW uranium was delivered to the target. Technological developments and accelerator improvements are being made over the entire facility and are key to completion of the power ramp-up. Major technological developments entail the phased deployment of high-power beam-intercepting systems, including the charge strippers, the charge selection systems, the production target, and the beam dump, along with support systems, including non-conventional utilities (NCU) and remote handling facilities. Major accelerator improvements include renovations to aging legacy systems associated with experimental beam lines and system automation for improved operational efficiency and better machine availability. Experience must be gained to safely handle the increased radiological impacts associated with high beam power; extensive machine studies and advanced beam tuning procedures are needed to minimize uncontrolled beam losses for the desired operating conditions. This paper discusses the technological developments and accelerator improvements with emphasis on major R&D efforts.

Published
2024

39. Solar neutrino measurements using the full data period of Super-Kamiokande-IV

Author

Collaboration, Super-Kamiokande, Abe, K., Bronner, C., Hayato, Y., Hiraide, K., Hosokawa, K., Ieki, K., Ikeda, M., Imaizumi, S., Iyogi, K., Kameda, J., Kanemura, Y., Kaneshima, R., Kashiwagi, Y., Kataoka, Y., Kato, Y., Kishimoto, Y., Miki, S., Mine, S., Miura, M., Mochizuki, T., Moriyama, S., Nagao, Y., Nakahata, M., Nakano, Y., Nakayama, S., Noguchi, Y., Okada, T., Okamoto, K., Orii, A., Sato, K., Sekiya, H., Shiba, H., Shimizu, K., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Takenaka, A., Tanaka, H., Watanabe, S., Yano, T., Han, S., Kajita, T., Okumura, K., Tashiro, T., Tomiya, T., Wang, R., Wang, X., Yoshida, S., Bravo-Berguno, D., Fernandez, P., Labarga, L., Ospina, N., Zaldivar, B., Pointon, B. W., Blaszczyk, F. d. M., Kachulis, C., Kearns, E., Raaf, J. L., Stone, J. L., Wan, L., Wester, T., Bian, J., Griskevich, N. J., Kropp, W. R., Locke, S., Smy, M. B., Sobel, H. W., Takhistov, V., Weatherly, P., Yankelevich, A., Ganezer, K. S., Hill, J., Jang, M. C., Kim, J. Y., Lee, S., Lim, I. T., Moon, D. H., Park, R. G., Bodur, B., Scholberg, K., Walter, C. W., Beauchene, A., Bernard, L., Coffani, A., Drapier, O., Hedri, S. El, Giampaolo, A., Imber, J., Mueller, Th. A., Paganini, P., Rogly, R., Quilain, B., Santos, A., Nakamura, T., Jang, J. S., Machado, L. N., Learned, J. G., Matsuno, S., Iovine, N., Choi, K., Cao, S., Anthony, L. H. V., Litchfield, R. P., Prouse, N., Marin, D., Scott, M., Sztuc, A. A., Uchida, Y., Berardi, V., Catanesi, M. G., Intonti, R. A., Radicioni, E., Calabria, N. F., De Rosa, G., Langella, A., Collazuol, G., Iacob, F., Lamoureux, M., Mattiazzi, M., Ludovici, L., Gonin, M., Perisse, L., Pronost, G., Fujisawa, C., Maekawa, Y., Nishimura, Y., Okazaki, R., Friend, M., Hasegawa, T., Ishida, T., Jakkapu, M., Kobayashi, T., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Boschi, T., Bhuiyan, N., Burton, G. T., Gao, J., Goldsack, A., Katori, T., Di Lodovico, F., Migenda, J., Sedgwick, S. Molina, Ramsden, R. M., Taani, M., Xie, Z., Zsoldos, S., Abe, KE., Hasegawa, M., Isobe, Y., Kotsar, Y., Miyabe, H., Ozaki, H., Shiozawa, T., Sugimoto, T., Suzuki, A. T., Takagi, Y., Takeuchi, Y., Yamamoto, S., Zhong, H., Ashida, Y., Feng, J., Feng, L., Hayashino, T., Hirota, S., Hu, J. R., Hu, Z., Jiang, M., Kawaue, M., Kikawa, T., Mori, M., Nakamura, KE., Nakaya, T., Wendell, R. A., Yasutome, K., Jenkins, S. J., McCauley, N., Mehta, P., Pritchard, A., Tarrant, A., Wilking, M. J., Fukuda, Y., Itow, Y., Menjo, H., Murase, M., Ninomiya, K., Niwa, T., Tsukada, M., Yoshioka, Y., Frankiewicz, K., Lagoda, J., Mandal, M., Mijakowski, P., Prabhu, Y. S., Zalipska, J., Jiang, J., Jia, M., Jung, C. K., Palomino, J. L., Santucci, G., Shi, W., Vilela, C., Yanagisawa, C., Fukuda, D., Hagiwara, K., Harada, M., Hino, Y., Horai, T., Ishino, H., Ito, S., Kitagawa, H., Koshio, Y., Ma, W., Nakanishi, F., Piplani, N., Sakai, S., Sakuda, M., Tada, T., Tano, T., Xu, C., Yamaguchi, R., Ishizuka, T., Kuno, Y., Barr, G., Barrow, D., Cook, L., Samani, S., Simpson, C., Wark, D., Holin, A. M., Nova, F., Jung, S., Yang, B., Yang, J. Y., Yoo, J., Fannon, J. E. P., Kneale, L., Malek, M., McElwee, J. M., Stone, O., Thiesse, M. D., Thompson, L. F., Wilson, S. T., Okazawa, H., Lakshmi, S. M., Choi, Y., Kim, S. B., Kwon, E., Seo, J. W., Yu, I., Ichikawa, A. K., Tairahune, S., Nishijima, K., Eguchi, A., Iwamoto, K., Nakagiri, K., Nakajima, Y., Ogawa, N., Shima, S., Watanabe, E., Yokoyama, M., Calland, R. G., Fujita, S., Jesus-Valls, C., Junjie, X., Ming, T. K., de Perio, P., Martens, K., Murdoch, M., Vagins, M. R., Izumiyama, S., Kuze, M., Matsumoto, R., Okajima, Y., Tanaka, M., Yoshida, T., Inomoto, M., Ishitsuka, M., Ito, H., Kinoshita, T., Ohta, K., Ommura, Y., Shinoki, M., Shigeta, N., Suganuma, T., Yamaguchi, K., Martin, J. F., Nantais, C. M., Tanaka, H. A., Towstego, T., Gaur, R., Gousy-Leblanc, V., Hartz, M., Konaka, A., Li, X., Chen, S., Xu, B. D., Zhang, B., Berkman, S., Posiadala-Zezula, M., Boyd, S. B., Edwards, R., Hadley, D., Nicholson, M., O'Flaherty, M., Richards, B., Ali, A., Jamieson, B., Walker, J., Amanai, S., Marti, Ll., Minamino, A., Pintaudi, G., Sano, S., Sasaki, R., Suzuki, S., and Wada, K.

Subjects
High Energy Physics - Experiment
Abstract

An analysis of solar neutrino data from the fourth phase of Super-Kamiokande~(SK-IV) from October 2008 to May 2018 is performed and the results are presented. The observation time of the data set of SK-IV corresponds to $2970$~days and the total live time for all four phases is $5805$~days. For more precise solar neutrino measurements, several improvements are applied in this analysis: lowering the data acquisition threshold in May 2015, further reduction of the spallation background using neutron clustering events, precise energy reconstruction considering the time variation of the PMT gain. The observed number of solar neutrino events in $3.49$--$19.49$ MeV electron kinetic energy region during SK-IV is $65,443^{+390}_{-388}\,(\mathrm{stat.})\pm 925\,(\mathrm{syst.})$ events. Corresponding $\mathrm{^{8}B}$ solar neutrino flux is $(2.314 \pm 0.014\, \rm{(stat.)} \pm 0.040 \, \rm{(syst.)}) \times 10^{6}~\mathrm{cm^{-2}\,s^{-1}}$, assuming a pure electron-neutrino flavor component without neutrino oscillations. The flux combined with all SK phases up to SK-IV is $(2.336 \pm 0.011\, \rm{(stat.)} \pm 0.043 \, \rm{(syst.)}) \times 10^{6}~\mathrm{cm^{-2}\,s^{-1}}$. Based on the neutrino oscillation analysis from all solar experiments, including the SK $5805$~days data set, the best-fit neutrino oscillation parameters are $\rm{sin^{2} \theta_{12,\,solar}} = 0.306 \pm 0.013 $ and $\Delta m^{2}_{21,\,\mathrm{solar}} = (6.10^{+ 0.95}_{-0.81}) \times 10^{-5}~\rm{eV}^{2}$, with a deviation of about 1.5$\sigma$ from the $\Delta m^{2}_{21}$ parameter obtained by KamLAND. The best-fit neutrino oscillation parameters obtained from all solar experiments and KamLAND are $\sin^{2} \theta_{12,\,\mathrm{global}} = 0.307 \pm 0.012 $ and $\Delta m^{2}_{21,\,\mathrm{global}} = (7.50^{+ 0.19}_{-0.18}) \times 10^{-5}~\rm{eV}^{2}$., Comment: 47 pages, 61 figures

Published
2023
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40. Search for the semileptonic decays $\Xi_c^0 \to \Xi^0\ell^+\ell^-$ at Belle

Author

Belle Collaboration, Cui, J. X., Li, Y. B., Shen, C. P., Adachi, I., Aihara, H., Said, S. Al, Asner, D. M., Aushev, T., Ayad, R., Babu, V., Bahinipati, S., Banerjee, Sw., Bauer, M., Behera, P., Belous, K., Bennett, J., Bessner, M., Bhuyan, B., Bilka, T., Biswas, D., Bobrov, A., Bodrov, D., Borah, J., Bračko, M., Branchini, P., Browder, T. E., Budano, A., Campajola, M., Červenkov, D., Chang, M. -C., Cheon, B. G., Chilikin, K., Cho, K., Choi, S. -K., Choi, Y., Choudhury, S., Das, S., Dash, N., De Nardo, G., De Pietro, G., Dhamija, R., Di Capua, F., Dingfelder, J., Doležal, Z., Dong, T. V., Dubey, S., Ecker, P., Epifanov, D., Ferber, T., Ferlewicz, D., Fulsom, B. G., Garg, R., Gaur, V., Garmash, A., Giri, A., Goldenzweig, P., Graziani, E., Gudkova, K., Hadjivasiliou, C., Halder, S., Hayasaka, K., Hayashii, H., Hazra, S., Herrmann, D., Hou, W. -S., Hsu, C. -L., Inami, K., Ipsita, N., Ishikawa, A., Itoh, R., Iwasaki, M., Jacobs, W. W., Jia, S., Jin, Y., Kalita, D., Kiesling, C., Kim, D. Y., Kim, K. -H., Kim, Y. -K., Kinoshita, K., Kodyš, P., Korobov, A., Korpar, S., Kovalenko, E., Križan, P., Krokovny, P., Kuhr, T., Kumar, D., Kumar, R., Kwon, Y. -J., Lam, T., Lee, S. C., Li, L. K., Li, Y., Gioi, L. Li, Libby, J., Liventsev, D., Ma, Y., Masuda, M., Matvienko, D., Maurya, S. K., Meier, F., Merola, M., Miyabayashi, K., Mizuk, R., Mussa, R., Nakao, M., Natkaniec, Z., Natochii, A., Nayak, L., Nishida, S., Ogawa, S., Ono, H., Oskin, P., Pakhlov, P., Pakhlova, G., Pardi, S., Park, H., Park, J., Park, S. -H., Patra, S., Paul, S., Pedlar, T. K., Pestotnik, R., Piilonen, L. E., Podobnik, T., Prim, M. T., Rout, N., Russo, G., Sandilya, S., Santelj, L., Savinov, V., Schnell, G., Schwanda, C., Seino, Y., Senyo, K., Sevior, M. E., Shan, W., Sharma, C., Shiu, J. -G., Sokolov, A., Solovieva, E., Starič, M., Stottler, Z. S., Sumihama, M., Takizawa, M., Tanida, K., Tenchini, F., Tiwary, R., Uglov, T., Unno, Y., Uno, S., Usov, Y., Vinokurova, A., Wang, M. -Z., Watanuki, S., Won, E., Yabsley, B. D., Yan, W., Yelton, J., Yin, J. H., Yuan, L., Zhang, Z. P., Zhilich, V., and Zhukova, V.

Subjects
High Energy Physics - Experiment
Abstract

Using the full data sample of 980 $\mathrm{fb}^{-1}$ collected with the Belle detector at the KEKB asymmetric energy electron-positron collider, we report the results of the first search for the rare semileptonic decays $\Xi_c^0 \to \Xi^0\ell^+\ell^-$ ($\ell=e$ or $\mu)$. No significant signals are observed in the $\Xi^0\ell^+\ell^-$ invariant-mass distributions. Taking the decay $\Xi_c^0 \to \Xi^- \pi^+$ as the normalization mode, we report 90\% credibility upper limits on the branching fraction ratios ${\cal{B}} (\Xi_c^0 \to \Xi^0 e^+ e^-) / {\cal{B}}(\Xi_c^0\to \Xi^-\pi^+) < 6.7 \times 10^{-3}$ and ${\cal{B}} (\Xi_c^0 \to \Xi^0 \mu^+ \mu^-) / {\cal{B}}(\Xi_c^0\to \Xi^-\pi^+) < 4.3 \times 10^{-3}$ based on the phase-space assumption for signal decays. The 90\% credibility upper limits on the absolute branching fractions of ${\cal{B}} (\Xi_c^0 \to \Xi^0 e^+ e^-)$ and ${\cal{B}} (\Xi_c^0 \to \Xi^0 \mu^+ \mu^-)$ are found to be $9.9 \times 10^{-5}$ and $6.5 \times 10^{-5}$, respectively., Comment: 8 pages, 4 figures, submitted to PRD

Published
2023
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44. Search for the decay $B_s^0\to J/\psi\pi^0$ at Belle experiment

Author

Belle Collaboration, Kumar, D., Bhuyan, B., Aihara, H., Asner, D. M., Aushev, T., Ayad, R., Babu, V., Banerjee, Sw., Bauer, M., Behera, P., Belous, K., Bennett, J., Bessner, M., Bilka, T., Biswas, D., Bobrov, A., Bodrov, D., Borah, J., Bračko, M., Branchini, P., Browder, T. E., Budano, A., Campajola, M., Červenkov, D., Chang, M. -C., Chen, C., Cheon, B. G., Chilikin, K., Cho, K., Choi, S. -K., Choi, Y., Choudhury, S., Das, S., Dash, N., De Nardo, G., De Pietro, G., Dhamija, R., Doležal, Z., Dong, T. V., Ecker, P., Epifanov, D., Ferlewicz, D., Fulsom, B. G., Garg, R., Gaur, V., Garmash, A., Giri, A., Goldenzweig, P., Graziani, E., Gudkova, K., Hadjivasiliou, C., Hayasaka, K., Hayashii, H., Hazra, S., Herrmann, D., Hou, W. -S., Hsu, C. -L., Ipsita, N., Ishikawa, A., Itoh, R., Iwasaki, M., Jacobs, W. W., Jia, S., Jin, Y., Kalita, D., Kaliyar, A. B., Kiesling, C., Kim, C. H., Kim, D. Y., Kim, K. -H., Kim, Y. -K., Kinoshita, K., Kodyš, P., Korobov, A., Korpar, S., Kovalenko, E., Križan, P., Krokovny, P., Kuhr, T., Kumar, R., Kumara, K., Kumita, T., Kuzmin, A., Kwon, Y. -J., Lam, T., Lee, S. C., Levit, D., Li, L. K., Li, Y., Li, Y. B., Gioi, L. Li, Libby, J., Liventsev, D., Ma, Y., Masuda, M., Matsuda, T., Matvienko, D., Maurya, S. K., Meier, F., Merola, M., Metzner, F., Miyabayashi, K., Mizuk, R., Mohanty, G. B., Mussa, R., Nakao, M., Natkaniec, Z., Natochii, A., Nayak, L., Nayak, M., Nishida, S., Ogawa, S., Ono, H., Pakhlov, P., Pakhlova, G., Pardi, S., Park, J., Park, S. -H., Passeri, A., Paul, S., Pedlar, T. K., Pestotnik, R., Piilonen, L. E., Podobnik, T., Prim, M. T., Rout, N., Russo, G., Sandilya, S., Santelj, L., Savinov, V., Schnell, G., Schwanda, C., Seino, Y., Sevior, M. E., Shan, W., Sharma, C., Shen, C. P., Shiu, J. -G., Singh, J. B., Solovieva, E., Starič, M., Stottler, Z. S., Sumihama, M., Takizawa, M., Tanida, K., Tenchini, F., Tiwary, R., Uglov, T., Unno, Y., Uno, S., Ushiroda, Y., Vahsen, S. E., Varvell, K. E., Vinokurova, A., Wang, D., Wang, X. L., Watanuki, S., Won, E., Yabsley, B. D., Yan, W., Yelton, J., Yin, J. H., Yuan, L., Zhang, Z. P., Zhilich, V., and Zhukova, V.

Subjects
High Energy Physics - Experiment
Abstract

We have analyzed 121.4 fb$^{-1}$ of data collected at the $\Upsilon(5S)$ resonance by the Belle experiment using the KEKB asymmetric-energy $e^+e^-$ collider to search for the decay $B_s^0\to J/\psi\pi^0$. We observe no signal and report an upper limit on the branching fraction $\mathcal{B}(B_s^0\to J/\psi\pi^0)$ of $1.21\times 10^{-5}$ at 90\% confidence level. This result is the most stringent, improving the previous bound by two orders of magnitude., Comment: Published in PRD

Published
2023
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45. Kondo screening in a Majorana metal

Author

Lee, S., Choi, Y. S., Do, S. -H., Lee, W., Lee, C. H., Lee, M., Vojta, M., Wang, C. N., Luetkens, H., Guguchia, Z., and Choi, K. -Y.

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

Kondo impurities provide a nontrivial probe to unravel the character of the excitations of a quantum spin liquid. In the S=1/2 Kitaev model on the honeycomb lattice, Kondo impurities embedded in the spin-liquid host can be screened by itinerant Majorana fermions via gauge-flux binding. Here, we report experimental signatures of metallic-like Kondo screening at intermediate temperatures in the Kitaev honeycomb material {\alpha}-RuCl3 with dilute Cr3+ (S=3/2) impurities. The static magnetic susceptibility, the muon Knight shift, and the muon spin-relaxation rate all feature logarithmic divergences, a hallmark of a metallic Kondo effect. Concurrently, the linear coefficient of the magnetic specific heat is large in the same temperature regime, indicating the presence of a host Majorana metal. This observation opens new avenues for exploring uncharted Kondo physics in insulating quantum magnets., Comment: published in Nature Communications, 37 pages, 10 figures

Published
2023

46. Measurement of the Ratio of Partial Branching Fractions of Inclusive $\overline{B} \to X_u \ell \overline{\nu}$ to $\overline{B} \to X_{c} \ell \overline{\nu}$ and the Ratio of their Spectra with Hadronic Tagging

Author

Belle Collaboration, Hohmann, M., Urquijo, P., Adachi, I., Aihara, H., Asner, D. M., Aushev, T., Ayad, R., Babu, V., Banerjee, Sw., Bauer, M., Bennett, J., Bernlochner, F., Bessner, M., Bhuyan, B., Bilka, T., Biswas, D., Bobrov, A., Bodrov, D., Bonvicini, G., Borah, J., Bozek, A., Bračko, M., Branchini, P., Browder, T. E., Budano, A., Campajola, M., Cao, L., Chang, M. -C., Cheon, B. G., Cho, K., Choi, S. -K., Choi, Y., Das, S., Dash, N., De Nardo, G., De Pietro, G., Dhamija, R., Dingfelder, J., Doležal, Z., Dong, T. V., Dubey, S., Ecker, P., Ferber, T., Ferlewicz, D., Frey, A., Fulsom, B. G., Gaur, V., Giri, A., Goldenzweig, P., Graziani, E., Gu, T., Gudkova, K., Hadjivasiliou, C., Hartbrich, O., Hayasaka, K., Hayashii, H., Hazra, S., Hedges, M. T., Herrmann, D., Hou, W. -S., Hsu, C. -L., Inami, K., Ishikawa, A., Itoh, R., Iwasaki, M., Jacobs, W. W., Ji, Q. P., Jia, S., Jin, Y., Kawasaki, T., Kiesling, C., Kim, D. Y., Kim, K. -H., Kim, Y. -K., Kinoshita, K., Korobov, A., Kovalenko, E., Križan, P., Kuhr, T., Kumar, M., Kumar, R., Kumara, K., Kwon, Y. -J., Lam, T., Laurenza, M., Lee, S. C., Levit, D., Lewis, P., Li, L. K., Gioi, L. Li, Liventsev, D., Masuda, M., Matsuda, T., Matvienko, D., Maurya, S. K., Meier, F., Merola, M., Metzner, F., Mizuk, R., Miyabayashi, K., Mohanty, G. B., Mussa, R., Nakao, M., Natkaniec, Z., Natochii, A., Nayak, L., Nishida, S., Ogawa, S., Ono, H., Oskin, P., Pakhlova, G., Pardi, S., Park, H., Park, J., Park, S. -H., Passeri, A., Patra, S., Paul, S., Pedlar, T. K., Pestotnik, R., Piilonen, L. E., Podobnik, T., Prencipe, E., Prim, M. T., Röhrken, M., Rozanska, M., Russo, G., Sandilya, S., Savinov, V., Schnell, G., Schwanda, C., Schwartz, A. J., Seino, Y., Senyo, K., Shan, W., Sharma, C., Shiu, J. -G., Shwartz, B., Solovieva, E., Starič, M., Sumihama, M., Sumisawa, K., Takizawa, M., Tanida, K., Tenchini, F., Trabelsi, K., Uchida, M., Uno, S., Vahsen, S. E., Varvell, K. E., Vinokurova, A., Wang, M. -Z., Won, E., Yabsley, B. D., Yan, W., Yang, S. B., Yook, Y., Zhilich, V., and Zhukova, V.

Subjects
High Energy Physics - Experiment
Abstract

We present a measurement of the ratio of partial branching fractions of the semi-leptonic inclusive decays, $\overline{B} \to X_{u} \ell \overline{\nu}$ to $\overline{B} \to X_{c} \ell \overline{\nu}$, where $\ell = (e, \mu)$, using the full Belle sample of $772 \times 10^{6}$ $B \kern 0.18em\overline{\kern -0.18em B}$ pairs collected at the $\Upsilon(4S)$ resonance. The ratio is measured via a two-dimensional fit to the squared four-momentum transfer to the lepton pair, and the charged lepton energy in the $B$ meson rest frame, where the latter must be larger than $1$ Ge\kern -0.1em V, covering approximately $86\%$ and $78\%$ of the $\overline{B} \to X_{u} \ell \overline{\nu}$ and $\overline{B} \to X_{c} \ell \overline{\nu}$ phase space, respectively. We find $\Delta \mathcal{B}(\overline{B} \to X_{u} \ell \overline{\nu})/ \Delta \mathcal{B}(\overline{B} \to X_{c} \ell \overline{\nu}) = 0.0196(1 \pm 8.4\%_{\rm stat} \pm 7.9\%_{\rm syst})$ where the uncertainties are statistical and systematic, respectively. In addition, we report the partial branching fractions separately for charged and neutral $B$ meson decays, and for electron and muon decay channels. We place a limit on isospin breaking in $\overline{B} \to X_{u} \ell \overline{\nu}$ decays, and find no indication of lepton flavor universality violation in either the charmed or charmless mode. Furthermore, we unfold the $\overline{B} \to X_{u} \ell \overline{\nu}$ and $\overline{B} \to X_{c} \ell \overline{\nu}$ yields and report the differential ratio in lepton energy and four-momentum transfer squared., Comment: 22 pages, 13 figures

Published
2023

47. Measurement of Angular Coefficients of $\bar{B} \to D^* \ell \bar{\nu}_\ell$: Implications for $|V_{cb}|$ and Tests of Lepton Flavor Universality

Author

Belle Collaboration, Prim, M. T., Bernlochner, F., Metzner, F., Aihara, H., Asner, D. M., Aushev, T., Ayad, R., Babu, V., Banerjee, Sw., Behera, P., Belous, K., Bennett, J., Bessner, M., Bhardwaj, V., Bhuyan, B., Bilka, T., Biswas, D., Bodrov, D., Bondar, A., Borah, J., Bračko, M., Branchini, P., Browder, T. E., Budano, A., Campajola, M., Cao, L., Červenkov, D., Chang, P., Cheon, B. G., Choi, S. -K., Choi, Y., Choudhury, S., Cochran, J., Das, S., Dash, N., De Nardo, G., De Pietro, G., Dhamija, R., Di Capua, F., Doležal, Z., Dong, T. V., Dubey, S., Ecker, P., Epifanov, D., Ferber, T., Ferlewicz, D., Fulsom, B. G., Garg, R., Gaur, V., Giri, A., weig, P. Goldenz, Gu, T., Gudkova, K., Hadjivasiliou, C., Hara, T., Hayashii, H., Hazra, S., Hedges, M. T., Herrmann, D., Villanueva, M. Hernández, Hou, W. -S., Hsu, C. -L., Inami, K., Inguglia, G., Ipsita, N., Ishikawa, A., Itoh, R., Iwasaki, M., Jacobs, W. W., Kiesling, C., Kim, C. H., Kim, D. Y., Kim, K. -H., Kodyš, P., Konno, T., Korobov, A., Korpar, S., Kovalenko, E., Križan, P., Krokovny, P., Kuhr, T., Kumar, M., Kumar, R., Kwon, Y. -J., Lam, T., Lee, S. C., Lewis, P., Li, L. K., Gioi, L. Li, Libby, J., Liventsev, D., Ma, Y., Matsuda, T., Matvienko, D., Maurya, S. K., Meier, F., Merola, M., Miyabayashi, K., Mizuk, R., Mohanty, G. B., Nakamura, I., Nakao, M., Narwal, D., Natkaniec, Z., Natochii, A., Nayak, L., Nishida, S., Ono, H., Oskin, P., Pakhlov, P., Pakhlova, G., Park, S. -H., Passeri, A., Patra, S., Pedlar, T. K., Pestotnik, R., Piilonen, L. E., Podobnik, T., Prencipe, E., Röhrken, M., Rout, N., Russo, G., Sandilya, S., Santelj, L., Savinov, V., Schmolz, P., Schnell, G., Schwanda, C., Seino, Y., Senyo, K., Shan, W., Shiu, J. -G., Singh, J. B., Solovieva, E., Starič, M., Stottler, Z. S., Sumihama, M., Takizawa, M., Tanida, K., Tenchini, F., Tiwary, R., Trabelsi, K., Unno, Y., Uno, S., Urquijo, P., Usov, Y., Vahsen, S. E., Varvell, K. E., Vossen, A., Wang, M. -Z., Wang, X. L., Won, E., Yabsley, B. D., Yan, W., Yang, S. B., Yin, J. H., Yuan, L., Zhang, Z. P., Zhilich, V., and Zhukova, V.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

We measure the complete set of angular coefficients $J_i$ for exclusive $\bar{B} \to D^* \ell \bar{\nu}_\ell$ decays ($\ell = e, \mu$). Our analysis uses the full $711\,\mathrm{fb}^{-1}$ Belle data set with hadronic tag-side reconstruction. The results allow us to extract the form factors describing the $B \to D^*$ transition and the Cabibbo-Kobayashi-Maskawa matrix element $|V_{\rm cb}|$. Using recent lattice QCD calculations for the hadronic form factors, we find $|V_{\rm cb}| = (41.0 \pm 0.7) \times 10^3 $ using the BGL parameterization, compatible with determinations from inclusive semileptonic decays. We search for lepton flavor universality violation as a function of the hadronic recoil parameter $w$, and investigate the differences of the electron and muon angular distributions. We find no deviation from Standard Model expectations.

Published
2023

48. A dark siren measurement of the Hubble constant using gravitational wave events from the first three LIGO/Virgo observing runs and DELVE

Author

Alfradique, V., Bom, C. R., Palmese, A., Teixeira, G., Santana-Silva, L., Drlica-Wagner, A., Riley, A. H., Martínez-Vázquez, C. E., Sand, D. J., Stringfellow, G. S., Medina, G. E., Carballo-Bello, J. A., Choi, Y., Esteves, J., Limberg, G., Mutlu-Pakdil, B., Noël, N. E. D., Pace, A. B., Sakowska, J. D., and Wu, J. F.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract

The current and next observation seasons will detect hundreds of gravitational waves (GWs) from compact binary systems coalescence at cosmological distances. When combined with independent electromagnetic measurements, the source redshift will be known, and we will be able to obtain precise measurements of the Hubble constant $H_0$ via the distance-redshift relation. However, most observed mergers are not expected to have electromagnetic counterparts, which prevents a direct redshift measurement. In this scenario, one of the possibilities is to use the dark sirens method that statistically marginalizes over all the potential host galaxies within the GW location volume to provide a probabilistic redshift to the source. Here we presented $H_{0}$ measurements using two new dark sirens compared to previous analyses using DECam data, GW190924$\_$021846 and GW200202$\_$154313. The photometric redshifts of the possible host galaxies of these two events are acquired from the DECam Local Volume Exploration Survey (DELVE) carried out on the Blanco telescope at Cerro Tololo in Chile. The combination of the $H_0$ posterior from GW190924$\_$021846 and GW200202$\_$154313 together with the bright siren GW170817 leads to $H_{0} = 68.84^{+15.51}_{-7.74}\, \rm{km/s/Mpc}$. Including these two dark sirens improves the 68% confidence interval (CI) by 7% over GW170817 alone. This demonstrates that the inclusion of well-localized dark sirens in such analysis improves the precision with which cosmological measurements can be made. Using a sample containing 10 well-localized dark sirens observed during the third LIGO/Virgo observation run, we determine a measurement of $H_{0} = 76.00^{+17.64}_{-13.45}\, \rm{km /s/Mpc}$., Comment: v2: minor corrections and references added

Published
2023

49. Search for baryon and lepton number violating decays $\boldsymbol{D \rightarrow p\ell}$

Author

Belle Collaboration, Maity, S., Garg, R., Bahinipati, S., Bhardwaj, V., Aihara, H., Said, S. Al, Asner, DM, Atmacan, H., Aushev, T., Ayad, R., Babu, V., Banerjee, Sw., Bauer, M., Bennett, J., Bessner, M., Biswas, D., Bobrov, A., Bodrov, D., Bonvicini, G., Borah, J., Bračko, M., Branchini, P., Budano, A., Campajola, M., Červenkov, D., Chang, M. -C., Chang, P., Chilikin, K., Cho, H. E., Cho, K., Cho, S. -J., Choi, S. -K., Choi, Y., Choudhury, S., Das, S., Dash, N., De Pietro, G., Dhamija, R., Di Capua, F., Dingfelder, J., Dong, TV, Ecker, P., Epifanov, D., Ferber, T., Fulsom, BG, Gaur, V., Giri, A., Goldenzweig, P., Graziani, E., Gu, T., Gudkova, K., Hadjivasiliou, C., Hayasaka, K., Hayashii, H., Hazra, S., Hou, W. -S., Hsu, C. -L., Inami, K., Ipsita, N., Ishikawa, A., Itoh, R., Iwasaki, M., Jacobs, WW, Jin, Y., Kalita, D., Kiesling, C., Kim, CH, Kim, DY, Kinoshita, K., }, P. Kody\v{s, Korobov, A., Korpar, S., Križan, P., Krokovny, P., Kumar, M., Kumar, R., Kumara, K., Kuzmin, A., Kwon, Y. -J., Lam, T., Lee, SC, Levit, D., Li, LK, Li, Y., Li, YB, Gioi, L. Li, Lieret, K., Liventsev, D., Masuda, M., Matsuda, T., Matvienko, D., Maurya, SK, Meier, F., Merola, M., Metzner, F., Mizuk, R., Mohanty, G. B., Mussa, R., Nakao, M., Narwal, D., Natochii, A., Nayak, L., Nishida, S., Ogawa, S., Ono, H., Oskin, P., Pakhlova, G., Pardi, S., Park, H., Park, J., Park, S. -H., Passeri, A., Patra, S., Paul, S., Pedlar, TK, Pestotnik, R., Piilonen, LE, Podobnik, T., Prell, S., Prencipe, E., Prim, MT, Rout, N., Russo, G., Sakai, Y., Sandilya, S., Santelj., L., Savinov, V., Schnell, G., Schwanda, C., Seino, Y., Senyo, K., Shan, W., Sharma, C., Shiu, J. -G., Solovieva, E., Starič, M., Sumihama, M., Takizawa, M., Tanida, K., Tenchini, F., Trabelsi, K., Uchida, M., Uglov, T., Unno, Y., Uno, S., Urquijo, P., Usov, Y., Varvell, K. E., Wang, E., Wang, M. -Z., Watanuki, S., Wiechczynski, J., Xu, X., Yabsley, B. D., Yan, W., Yang, S. B., Yin, J. H., Yuan, L., Zhang, Z. P., Zhilich, V., and Zhukova, V.

Subjects
High Energy Physics - Experiment
Abstract

We search for the baryon and lepton number violating charm decays, $D \rightarrow p\ell$, where $D$ is either a $D^0$ or a $\overline{D}^0$ and $\ell$ is a muon or an electron, using a data sample of $921\,\mathrm{fb}^{-1}$ collected by the Belle detector at the KEKB asymmetric energy $e^{+}e^{-}$ collider. In the absence of significant signals, we set upper limits on the branching fractions in the range $(5 - 8) \times 10^{-7}$ at a 90\% confidence level, depending on the decay mode., Comment: 6 pages, 4 figures, PHYSICAL REVIEW D 109, L031101 (2024)[DOI: : 10.1103/PhysRevD.109.L031101]

Published
2023

50. Quantum spin nematic phase in a square-lattice iridate

Author

Kim, Hoon, Kim, Jin-Kwang, Kim, Jimin, Kim, Hyun-Woo J., Ha, Seunghyeok, Kim, Kwangrae, Lee, Wonjun, Kim, Jonghwan, Cho, Gil Young, Heo, Hyeokjun, Jang, Joonho, Strempfer, J., Fabbris, G., Choi, Y., Haskel, D., Kim, Jungho, Kim, J. -W., and Kim, B. J.

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

Spin nematic (SN) is a magnetic analog of classical liquid crystals, a fourth state of matter exhibiting characteristics of both liquid and solid. Particularly intriguing is a valence-bond SN, in which spins are quantum entangled to form a multi-polar order without breaking time-reversal symmetry, but its unambiguous experimental realization remains elusive. Here, we establish a SN phase in the square-lattice iridate Sr$_2$IrO$_4$, which approximately realizes a pseudospin one-half Heisenberg antiferromagnet (AF) in the strong spin-orbit coupling limit. Upon cooling, the transition into the SN phase at T$_C$ $\approx$ 263 K is marked by a divergence in the static spin quadrupole susceptibility extracted from our Raman spectra, and concomitant emergence of a collective mode associated with the spontaneous breaking of rotational symmetries. The quadrupolar order persists in the antiferromagnetic (AF) phase below T$_N$ $\approx$ 230 K, and becomes directly observable through its interference with the AF order in resonant x-ray diffraction, which allows us to uniquely determine its spatial structure. Further, we find using resonant inelastic x-ray scattering a complete breakdown of coherent magnon excitations at short-wavelength scales, suggesting a resonating-valence-bond-like quantum entanglement in the AF state. Taken together, our results reveal a quantum order underlying the N\'eel AF that is widely believed to be intimately connected to the mechanism of high temperature superconductivity (HTSC)., Comment: Published in https://www.nature.com/articles/s41586-023-06829-4

Published
2023
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