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433 results on '"Choi, Kuiwon"'

1. Biomimetic Aggrecan Reduces Cartilage Extracellular Matrix From Degradation and Lowers Catabolic Activity in Ex Vivo and In Vivo Models

Author

Sharma, Shaili, Lee, Aeju, Choi, Kuiwon, Kim, Kwangmeyung, Youn, Inchan, Trippel, Stephen B, and Panitch, Alyssa

Subjects
Control Engineering, Mechatronics and Robotics, Engineering, Biomedical Engineering, Regenerative Medicine, Arthritis, Osteoarthritis, Aging, Biotechnology, Musculoskeletal, Aged, Aged, 80 and over, Aggrecans, Animals, Biomimetic Materials, Cartilage, Articular, Cattle, Chondrocytes, Chondroitin Sulfates, Cytokines, Disease Models, Animal, Extracellular Matrix, Gene Expression Regulation, Humans, Hyaluronic Acid, Inflammation Mediators, Matrix Metalloproteinase 13, Middle Aged, Rats, Rats, Sprague-Dawley, aggrecan, biomimetics, cartilage, extracellular matrix, proteolytic enzymes, Macromolecular and Materials Chemistry, Chemical Engineering, Polymers, Macromolecular and materials chemistry, Biomedical engineering
Abstract

Aggrecan, a major macromolecule in cartilage, protects the extracellular matrix (ECM) from degradation during the progression of osteoarthritis (OA). However, aggrecan itself is also susceptible to proteolytic cleavage. Here, the use of a biomimetic proteoglycan (mAGC) is presented, which functionally mimics aggrecan but lacks the known cleavage sites, protecting the molecule from proteolytic degradation. The objective of this study is to test the efficacy of this molecule in ex vivo (human OA synovial fluid) and in vivo (Sprague-Dawley rats) osteoarthritic models. These results indicate that mAGC's may protect articular cartilage against the loss of key ECM components, and lower catabolic protein and gene expression in both models. This suppression of matrix degradation has the potential to provide a healthy environment for tissue repair.

Published
2013

8. 3D Visualization for Tele-medical Diagnosis

Author

Yoo, Sun K., Key, Jaehong, Choi, Kuiwon, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Gavrilova, Marina, editor, Gervasi, Osvaldo, editor, Kumar, Vipin, editor, Tan, C. J. Kenneth, editor, Taniar, David, editor, Laganá, Antonio, editor, Mun, Youngsong, editor, and Choo, Hyunseung, editor

Published
2006
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11. Web-Based Hybrid Visualization of Medical Images

Author

Yoo, Sun K., Key, Jaehong, Choi, Kuiwon, Jo, Jinho, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Leow, Wee-Kheng, editor, Lew, Michael S., editor, Chua, Tat-Seng, editor, Ma, Wei-Ying, editor, Chaisorn, Lekha, editor, and Bakker, Erwin M., editor

Published
2005
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40. Estimation of muscle response using three-dimensional musculoskeletal models before impact situation: a simulation study

Author

Bae, Tae Soo, Loan, Peter, Choi, Kuiwon, Hong, Daehie, and Mun, Mu Seong

Subjects
Muscles -- Research, Muscles -- Models, Muscles -- Mechanical properties, Skeleton -- Research, Skeleton -- Models, Engineering and manufacturing industries, Science and technology
Abstract

When car crash experiments are performed using cadavers or dummies, the active muscles' reaction on crash situations cannot be observed. The aim of this study is to estimate muscles' response of the major muscle groups using three-dimensional musculoskeletal model by dynamic simulations of low-speed sled-impact. The three-dimensional musculoskeletal models of eight subjects were developed, including 241 degrees of freedom and 86 muscles. The muscle parameters considering limb lengths and the forcegenerating properties of the muscles were redefined by optimization to fit for each subject. Kinematic data and external forces measured by motion tracking system and dynamometer were then input as boundary conditions. Through a least-squares optimization algorithm, active muscles' responses were calculated during inverse dynamic analysis tracking the motion of each subject. Electromyography for major muscles at elbow, knee, and ankle joints was measured to validate each model. For low-speed sled-impact crash, experiment and simulation with optimized and unoptimized muscle parameters were performed at 9.4 m/h and 10 m/h and muscle activities were compared among them. The muscle activities with optimized parameters were closer to experimental measurements than the results without optimization. In addition, the extensor muscle activities at knee, ankle, and elbow joint were found considerably at impact time, unlike previous studies using cadaver or dummies. This study demonstrated the need to optimize the muscle parameters to predict impact situation correctly in computational studies using musculoskeletal models. And to improve accuracy of analysis for car crash injury using humanlike dummies, muscle reflex function, major extensor muscles' response at elbow, knee, and ankle joints, should be considered. [DOI: 10.1115/1.4002795] Keywords: low-speed impact, 3D musculoskeletal model muscle parameters, muscle responses

Published
2010

42. An anatomical and biomechanical comparison of anteromedial and anterolateral approaches for tibial tunnel of posterior cruciate ligament reconstruction: evaluation of the widening effect of the anterolateral approach

Author

Ahn, Jin Hwan, Bae, Ji Hoon, Lee, Yong Seuk, Choi, Kuiwon, Bae, Tae Soo, and Wang, Joon Ho

Subjects
Orthopedic surgery -- Methods, Orthopedic surgery -- Patient outcomes, Orthopedic surgery -- Research, Posterior cruciate ligament -- Injuries, Posterior cruciate ligament -- Physiological aspects, Posterior cruciate ligament -- Research, Health, Sports and fitness
Published
2009

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