Search

Fission 99Mo, which is one of the fission products from the irradiated 235U target, has been mainly produced through the dissolving procedure in an alkali solution. However, this approach has problems with the explosion of the generated hydrogen gas. In this research, we designed the porous alumina ball immobilized in CuO (CuO‐PAB) for the hydrogen removal. The CuO‐PAB was prepared by calcining the commercial PAB absorbed Cu ion. The nano‐sized CuO particles are distributed evenly in the porous network of PAB without any significant aggregation. Also, the wall of the PAB's pore channel hinders the aggregation and growth of CuO particles during the hydrogen removal process. These structural benefits show that the CuO‐PAB is superior to bulk‐CuO at the capacity and reaction rate of hydrogen conversion. Furthermore, these performances were durable in the recycling experiments. [ABSTRACT FROM AUTHOR]

This separation study employed reversed-phase ion-pair liquid chromatography, which uses a silica gel containing polar groups such as nitrile and alkyl siloxane as a stationary phase to prepare high-purity Lu from an enriched Yb target. Adequate mobile phases were identified for the selected columns, and the reproducibility of separation was assessed during a continuous use of the columns. No-carrier added (nca) Lu was perfectly separated from 10 mg of the YbO target that had been neutron-irradiated in the HANARO reactor, and the separation performance of the column was unaffected after 10 repeated separations. The results of this study are expected to be useful when applied to produce nca Lu of a few hundred mCi using a several milligram Yb target, or an additional purification stage to produce curies-level Lu with bulk a YbO target. [ABSTRACT FROM AUTHOR]

Abstract: Technetium coordination chemistry has been a subject of interest in the development of radiopharmaceuticals, especially imaging radiotracers. Due to the extensive work done on developing chelates for 99mTc, various chelators have been investigated and applied to radiopharmceuticals. Previous studies on the coordination chemistry of the [99mTc=O] core have established peptide-derived sequences as effective chelating ligands. These observations led to the design of tetradentate ligands derived from amino acid sequences. Such amino acid sequences provide a tetradentate coordination site for chelation to the radionuclide and an effective functional group for conjugation to biomolecules using conventional solid-phase synthetic routes. A derivative of a novel tripeptide chelating sequence, Pro–Gly–Cys (PGC) has been developed where it is possible to form stable technetium complexes with the [99mTc=O] via N3S1 tetradentate coordination core that serves this function and can be readily incorporated into biomolecules using solid-phase synthesis techniques. As a model system, the RGD peptide was selected which has been well known to target the integrin receptor for angiogenesis and tumor imaging agents. The results of in vivo studies with these novel radiolabeled compounds in tumor xenografts demonstrated a distribution in tumor targeting and other organs, such as kidney, liver and intestines. [ABSTRACT FROM AUTHOR]