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2. Selective Brain Hypothermia in Acute Ischemic Stroke: Reperfusion Without Reperfusion Injury

Author

Choi, Jae H, Poli, Sven, Chen, Michael, Nguyen, Thanh N, Saver, Jeffrey L, Matouk, Charles, and Pile-Spellman, John

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Neurosciences, Brain Disorders, Stroke, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, stroke, reperfusion, reperfusion injury, hypothermia, brain cooling, selective endovascular brain cooling, neuroprotection, Psychology, Clinical sciences, Biological psychology
Abstract

In acute ischemic stroke, early recanalization of the occluded artery is crucial for best outcome to be achieved. Recanalization aims at restoring blood flow to the ischemic tissue (reperfusion) and is achieved with pharmacological thrombolytic drugs, endovascular thrombectomy (EVT) devices, or both. The introduction of modern endovascular devices has led to tremendous anatomical and clinical success with rates of substantial reperfusion exceeding 80% and proven clinical benefit in patients with anterior circulation large vessel occlusions (LVOs). However, not every successful reperfusion procedure leads to the desired clinical outcome. In fact, the rate of non-disabled outcome at 3 months with current EVT treatment is ~1 out of 4. A constraint upon better outcomes is that reperfusion, though resolving ischemic stress, may not restore the anatomic structures and metabolic functions of ischemic tissue to their baseline states. In fact, ischemia triggers a complex cascade of destructive mechanisms that can sometimes be exacerbated rather than alleviated by reperfusion therapy. Such reperfusion injury may cause infarct progression, intracranial hemorrhage, and unfavorable outcome. Therapeutic hypothermia has been shown to have a favorable impact on the molecular elaboration of ischemic injury, but systemic hypothermia is limited by slow speed of attaining target temperatures and clinical complications. A novel approach is endovascular delivery of hypothermia to cool the affected brain tissue selectively and rapidly with tight local temperature control, features not available with systemic hypothermia devices. In this perspective article, we discuss the possible benefits of adjunctive selective endovascular brain hypothermia during interventional stroke treatment.

Published
2020

4. Non-invasive Dual-Channel Broadband Diffuse Optical Spectroscopy of Massive Hemorrhage and Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) in Swine

Author

Lam, Jesse H, O'Sullivan, Thomas D, Park, Tim S, Choi, Jae H, Warren, Robert V, Chen, Wen-Pin, McLaren, Christine E, Cancio, Leopoldo C, Batchinsky, Andriy I, and Tromberg, Bruce J

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Cardiovascular, Bioengineering, Animals, Aorta, Disease Models, Animal, Endovascular Procedures, Hemoglobins, Hemorrhage, Oxyhemoglobins, Quality of Health Care, Resuscitation, Spectrum Analysis, Swine, Human Movement and Sports Sciences, Public Health and Health Services, Strategic, Defence & Security Studies, Clinical sciences, Health services and systems
Abstract

ObjectiveTo quantitatively measure tissue composition and hemodynamics during resuscitative endovascular balloon occlusion of the aorta (REBOA) in two tissue compartments using non-invasive two-channel broadband diffuse optical spectroscopy (DOS).MethodsTissue concentrations of oxy- and deoxyhemoglobin (HbO2 and HbR), water, and lipid were measured in a porcine model (n = 10) of massive hemorrhage (65% total blood volume over 1 h) and 30-min REBOA superior and inferior to the aortic balloon.ResultsAfter hemorrhage, hemoglobin oxygen saturation (StO2 = HbO2/[HbO2 + HbR]) at both sites decreased significantly (-29.9% and -42.3%, respectively). The DOS measurements correlated with mean arterial pressure (MAP) (R2 = 0.79, R2 = 0.88), stroke volume (SV) (R2 = 0.68, R2 = 0.88), and heart rate (HR) (R2 = 0.72, R2 = 0.88). During REBOA, inferior StO2 continued to decline while superior StO2 peaked 12 min after REBOA before decreasing again. Inferior DOS parameters did not associate with MAP, SV, or HR during REBOA.ConclusionsDual-channel regional tissue DOS measurements can be used to non-invasively track the formation of hemodynamically distinct tissue compartments during hemorrhage and REBOA. Conventional systemic measures MAP, HR, and SV are uncorrelated with tissue status in inferior (downstream) sites. Multi-compartment DOS may provide a more complete picture of the efficacy of REBOA and similar resuscitation procedures.

Published
2018

8. Intravenous Autologous Bone Marrow–derived Mesenchymal Stromal Cells Delay Acute Respiratory Distress Syndrome in Swine

Author

Batchinsky, Andriy I., primary, Roberts, Teryn R., additional, Antebi, Ben, additional, Necsoiu, Corina, additional, Choi, Jae H., additional, Herzig, Maryanne, additional, Cap, Andrew P., additional, McDaniel, Jennifer S., additional, Rathbone, Christopher R., additional, Chung, Kevin K., additional, and Cancio, Leopoldo C., additional

Published
2023
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13. MultipleXed Population Selection and Enrichment single nucleus RNA sequencing (XPoSE-seq) enables sample identity retention during transcriptional profiling of rare populations

Author

Savell, Katherine E, primary, Madangopal, Rajtarun, additional, Saravanan, Padmashri, additional, Palaganas, Ryan G, additional, Woods, Kareem D, additional, Thompson, Drake J, additional, Drake, Olivia R, additional, Brenner, Megan B, additional, Weber, Sophia J, additional, Van Leer, Elise, additional, Choi, Jae H, additional, Martin, Toni L, additional, Martin, Jody C, additional, Steinberg, Mia K, additional, Austin, James W, additional, Charendoff, Chloe I, additional, and Hope, Bruce T, additional

Published
2023
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24. Global Impact of COVID-19 on Stroke Care and Intravenous Thrombolysis

Author

Nogueira, Raul G, Qureshi, Muhammed M, Abdalkader, Mohamad, Martins, Sheila Ouriques, Yamagami, Hiroshi, Qiu, Zhongming, Mansour, Ossama Yassin, Sathya, Anvitha, Czlonkowska, Anna, Tsivgoulis, Georgios, Aguiar de Sousa, Diana, Demeestere, Jelle, Mikulik, Robert, Vanacker, Peter, Siegler, James E, Kõrv, Janika, Biller, Jose, Liang, Conrad W, Sangha, Navdeep S, Zha, Alicia M, Czap, Alexandra L, Holmstedt, Christine Anne, Turan, Tanya N, Ntaios, George, Malhotra, Konark, Tayal, Ashis, Loochtan, Aaron, Ranta, Annamarei, Mistry, Eva A, Alexandrov, Anne W, Huang, David Y, Yaghi, Shadi, Raz, Eytan, Sheth, Sunil A, Mohammaden, Mahmoud H, Frankel, Michael, Bila Lamou, Eric Guemekane, Aref, Hany M, Elbassiouny, Ahmed, Hassan, Farouk, Menecie, Tarek, Mustafa, Wessam, Shokri, Hossam M, Roushdy, Tamer, Sarfo, Fred S, Alabi, Tolulope Oyetunde, Arabambi, Babawale, Nwazor, Ernest O, Sunmonu, Taofiki Ajao, Wahab, Kolawole, Yaria, Joseph, Mohammed, Haytham Hussein, Adebayo, Philip B, Riahi, Anis D, Ben Sassi, Samia, Gwaunza, Lenon, Ngwende, Gift Wilson, Sahakyan, David, Rahman, Aminur, Ai, Zhibing, Bai, Fanghui, Duan, Zhenhui, Hao, Yonggang, Huang, Wenguo, Li, Guangwen, Li, Wei, Liu, Ganzhe, Luo, Jun, Shang, Xianjin, Sui, Yi, Tian, Ling, Wen, Hongbin, Wu, Bo, Yan, Yuying, Yuan, Zhengzhou, Zhang, Hao, Zhang, Jun, Zhao, Wenlong, Zi, Wenjie, Leung, Thomas W, Chugh, Chandril, Huded, Vikram, Menon, Bindu, Pandian, Jeyaraj Durai, Sylaja, P N, Usman, Fritz Sumantri, Farhoudi, Mehdi, Hokmabadi, Elyar Sadeghi, Horev, Anat, Reznik, Anna, Hoffmann, Rotem Sivan, Ohara, Nobuyuki, Sakai, Nobuyuki, Watanabe, Daisuke, Yamamoto, Ryoo, Doijiri, Ryosuke, Tokuda, Naoki, Yamada, Takehiro, Terasaki, Tadashi, Yazawa, Yukako, Uwatoko, Takeshi, Dembo, Tomohisa, Shimizu, Hisao, Sugiura, Yuri, Miyashita, Fumio, Fukuda, Hiroki, Miyake, Kosuke, Shimbo, Junsuke, Sugimura, Yusuke, Yagita, Yoshiki, Takenobu, Yohei, Matsumaru, Yuji, Yamada, Satoshi, Kono, Ryuhei, Kanamaru, Takuya, Yamazaki, Hidekazu, Sakaguchi, Manabu, Todo, Kenichi, Yamamoto, Nobuaki, Sonoda, Kazutaka, Yoshida, Tomoko, Hashimoto, Hiroyuki, Nakahara, Ichiro, Kondybayeva, Aida, Faizullina, Kamila, Kamenova, Saltanat, Zhanuzakov, Murat, Baek, Jang-Hyun, Hwang, Yangha, Lee, Jin Soo, Lee, Si Baek, Moon, Jusun, Park, Hyungjong, Seo, Jung Hwa, Seo, Kwon-Duk, Sohn, Sung Il, Young, Chang Jun, Ahdab, Rechdi, Wan Zaidi, Wan Asyraf, Aziz, Zariah Abdul, Basri, Hamidon Bin, Chung, Law Wan, Ibrahim, Aznita Binti, Ibrahim, Khairul Azmi, Looi, Irene, Tan, Wee Yong, Yahya, Nafisah Wan, Groppa, Stanislav, Leahu, Pavel, Al Hashmi, Amal M, Imam, Yahia Zakaria, Akhtar, Naveed, Pineda-Franks, Maria Carissa, Co, Christian Oliver, Kandyba, Dmitriy, Alhazzani, Adel, Al-Jehani, Hosam, Tham, Carol Huilian, Mamauag, Marlie Jane, Venketasubramanian, Narayanaswamy, Chen, Chih-Hao, Tang, Sung-Chun, Churojana, Anchalee, Akil, Esref, Aykaç, Ozlem, Ozdemir, Atilla Ozcan, Giray, Semih, Hussain, Syed Irteza, John, Seby, Le Vu, Huynh, Tran, Anh Duc, Nguyen, Huy Hoang, Pham, Thong Nhu, Nguyen, Thang Huy, Nguyen, Trung Quoc, Gattringer, Thomas, Enzinger, Christian, Killer-Oberpfalzer, Monika, Bellante, Flavio, De Blauwe, Sofie, Vanhooren, Geert, De Raedt, Sylvie, Dusart, Anne, Lemmens, Robin, Ligot, Noemie, Rutgers, Matthieu Pierre, Yperzeele, Laetitia, Alexiev, Filip, Sakelarova, Teodora, Bedeković, Marina Roje, Budincevic, Hrvoje, Cindrić, Igor, Hucika, Zlatko, Ozretic, David, Saric, Majda Seferovic, Pfeifer, Frantiek, Karpowic, Igor, Cernik, David, Sramek, Martin, Skoda, Miroslav, Hlavacova, Helena, Klecka, Lukas, Koutny, Martin, Vaclavik, Daniel, Skoda, Ondrej, Fiksa, Jan, Hanelova, Katerina, Nevsimalova, Miroslava, Rezek, Robert, Prochazka, Petr, Krejstova, Gabriela, Neumann, Jiri, Vachova, Marta, Brzezanski, Henryk, Hlinovsky, David, Tenora, Dusan, Jura, Rene, Jurák, Lubomír, Novak, Jan, Novak, Ales, Topinka, Zdenek, Fibrich, Petr, Sobolova, Helena, Volny, Ondrej, Christensen, Hanne Krarup, Drenck, Nicolas, Iversen, Helle Klingenberg, Simonsen, Claus Z, Truelsen, Thomas Clement, Wienecke, Troels, Vibo, Riina, Gross-Paju, Katrin, Toomsoo, Toomas, Antsov, Katrin, Caparros, Francois, Cordonnier, Charlotte, Dan, Maria, Faucheux, Jean-Marc, Mechtouff, Laura, Eker, Omer, Lesaine, Emilie, Ondze, Basile, Peres, Roxane, Pico, Fernando, Piotin, Michel, Pop, Raoul, Rouanet, Francois, Gubeladze, Tatuli, Khinikadze, Mirza, Lobjanidze, Nino, Tsikaridze, Alexander, Nagel, Simon, Ringleb, Peter Arthur, Rosenkranz, Michael, Schmidt, Holger, Sedghi, Annahita, Siepmann, Timo, Szabo, Kristina, Thomalla, Götz, Palaiodimou, Lina, Sagris, Dimitrios, Kargiotis, Odysseas, Klivenyi, Peter, Szapary, Laszlo, Tarkanyi, Gabor, Adami, Alessandro, Bandini, Fabio, Calabresi, Paolo, Frisullo, Giovanni, Renieri, Leonardo, Sangalli, Davide, Pirson, Anne V, Uyttenboogaart, Maarten, van den Wijngaard, Ido, Kristoffersen, Espen Saxhaug, Brola, Waldemar, Fudala, Małgorzata, Horoch-Lyszczarek, Ewa, Karlinski, Michal, Kazmierski, Radoslaw, Kram, Pawel, Rogoziewicz, Marcin, Kaczorowski, Rafal, Luchowski, Piotr, Sienkiewicz-Jarosz, Halina, Sobolewski, Piotr, Fryze, Waldemar, Wisniewska, Anna, Wiszniewska, Malgorzata, Ferreira, Patricia, Ferreira, Paulo, Fonseca, Luisa, Marto, João Pedro, Pinho E Melo, Teresa, Nunes, Ana Paiva, Rodrigues, Miguel, Cruz, Vítor Tedim, Falup-Pecurariu, Cristian, Krastev, Georgi, Mako, Miroslav, Alonso de Leciñana, María, Arenillas, Juan F, Ayo-Martin, Oscar, Culebras, Antonio Cruz, Tejedor, Exuperio Diez, Montaner, Joan, Pérez-Sánchez, Soledad, Tola Arribas, Miguel Angel, Vasquez, Alejandro Rodriguez, Mazya, Michael, Bernava, Gianmarco, Brehm, Alex, Machi, Paolo, Fischer, Urs, Gralla, Jan, Michel, Patrik L, Psychogios, Marios-Nikos, Strambo, Davide, Banerjee, Soma, Krishnan, Kailash, Kwan, Joseph, Butt, Asif, Catanese, Luciana, Demchuk, Andrew, Field, Thalia, Haynes, Jennifer, Hill, Michael D, Khosravani, Houman, Mackey, Ariane, Pikula, Aleksandra, Saposnik, Gustavo, Scott, Courtney Anne, Shoamanesh, Ashkan, Shuaib, Ashfaq, Yip, Samuel, Barboza, Miguel A, Barrientos, Jose Domingo, Portillo Rivera, Ligia Ibeth, Gongora-Rivera, Fernando, Novarro-Escudero, Nelson, Blanco, Anmylene, Abraham, Michael, Alsbrook, Diana, Altschul, Dorothea, Alvarado-Ortiz, Anthony J, Bach, Ivo, Badruddin, Aamir, Barazangi, Nobl, Brereton, Charmaine, Castonguay, Alicia, Chaturvedi, Seemant, Chaudhry, Saqib A, Choe, Hana, Choi, Jae H, Dharmadhikari, Sushrut, Desai, Kinjal, Devlin, Thomas G, Doss, Vinodh T, Edgell, Randall, Etherton, Mark, Farooqui, Mudassir, Frei, Don, Gandhi, Dheeraj, Grigoryan, Mikayel, Gupta, Rishi, Hassan, Ameer E, Helenius, Johanna, Kaliaev, Artem, Kaushal, Ritesh, Khandelwal, Priyank, Khawaja, Ayaz M, Khoury, Naim N, Kim, Benny S, Kleindorfer, Dawn O, Koyfman, Feliks, Lee, Vivien H, Leung, Lester Y, Linares, Guillermo, Linfante, Italo, Lutsep, Helmi L, Macdougall, Lisa, Male, Shailesh, Malik, Amer, Masoud, Hesham, McDermott, Molly, Mehta, Brijesh P, Min, Jiangyong, Mittal, Manoj, Morris, Jane G, Multani, Sumeet S, Nahab, Fadi, Nalleballe, Krishna, Nguyen, Claude B, Novakovic-White, Roberta, Ortega-Gutierrez, Santiago, Rahangdale, Rahul H, Ramakrishnan, Pankajavalli, Romero, Jose Rafael, Rost, Natalia, Rothstein, Aaron, Ruland, Sean, Shah, Ruchir, Sharma, Malveeka, Silver, Brian, Simmons, Marc, Singh, Abhishek, Starosciak, Amy K, Strasser, Sheryl L, Szeder, Viktor, Teleb, Mohamed, Tsai, Jenny P, Voetsch, Barbara, Balaguera, Oscar, Pujol Lereis, Virginia A, Luraschi, Adriana, Almeida, Marcele Schettini, Cardoso, Fabricio Buchdid, Conforto, Adriana, De Deus Silva, Leonardo, Giacomini, Luidia Varrone, Lima, Fabricio Oliveira, Longo, Alexandre L, Magalhães, Pedro Sc, Martins, Rodrigo Targa, Mont'alverne, Francisco, Mora Cuervo, Daissy Liliana, Rebello, Leticia Costa, Valler, Lenise, Zetola, Viviane Flumignan, Lavados, Pablo M, Navia, Victor, Olavarría, Verónica V, Almeida Toro, Juan Manuel, Ricardo Amaya, Pablo Felipe, Bayona, Hernan, Corredor-Quintero, Angel Basilio, Rivera Ordonez, Carlos Eduardo, Mantilla Barbosa, Diana Katherine, Lara, Osvaldo, Patiño, Mauricio R, Diaz Escobar, Luis Fernando, Dejesus Melgarejo Farina, Donoband Edson, Villamayor, Analia Cardozo, Zelaya Zarza, Adolfo Javier, Barrientos Iman, Danny Moises, Kadota, Liliana Rodriguez, Campbell, Bruce, Hankey, Graeme J, Hair, Casey, Kleinig, Timothy, Ma, Alice, Martins, Rodrigo Tomazini, Sahathevan, Ramesh, Thijs, Vincent, Salazar, Daniel, Yuan-Hao Wu, Teddy, Haussen, Diogo C, Liebeskind, David, Yavagal, Dileep, Jovin, Tudor G, Zaidat, Osama O, and Nguyen, Thanh N

Subjects
610 Medicine & health
Abstract

OBJECTIVE The objectives of this study were to measure the global impact of the pandemic on the volumes for intravenous thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at the height of the pandemic (March 1 to June 30, 2020) compared with two control 4-month periods. METHODS We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, and 457 stroke centers. Diagnoses were identified by their ICD-10 codes and/or classifications in stroke databases. RESULTS There were 91,373 stroke admissions in the 4 months immediately before compared to 80,894 admissions during the pandemic months, representing an 11.5% (95%CI, -11.7 to - 11.3, p

Published
2021
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25. Global impact of the COVID-19 pandemic on stroke care and intravenous thrombolysis

Author

Thanh Nguyen, Phuong, Qureshi, Muhammad, Martins, Sheila, Yamagami, Hiroshi, Qiu, Zhongming, Mansour, Ossama, Czlonkowska, Anna, Abdalkader, Mohamad, Sathya, Anvitha, de Sousa, Diana Aguiar, Demeestere, Jelle, Mikulik, Robert, Vanacker, Peter, Siegler, James, Korv, Janika, Biller, Jose, Liang, Conrad, Sangha, Navdeep, Zha, Alicia, Czap, Alexandra, Holmstedt, Christine, Turan, Tanya, Grant, Cheryl, Ntaios, George, Malhotra, Konard, Tayal, Ashis, Loochtan, Aaron, Mistry, Eva, Alexandrov, Anne, Huang, David, Yaghi, Shadi, Raz, Eytan, Sheth, Sunil, Frankel, Michael, Lamou, Eric Gueumekane Bila, Aref, Hany, Elbassiouny, Ahmed, Hassan, Farouk, Mustafa, Wessam, Menecie, Tarek, Shokri, Hossam, Roushdy, Tamer, Sarfo, Fred Stephen, Alabi, Tolulope, Arabambi, Babawale, Nwazor, Ernest, Sunmonu, Taofiki Ajao, Wahab, Kolawole W., Mohammed, Haythem Hussein, Adebayo, Philip B., Riahi, Anis, Ben Sassi, Samia, Gwaunza, Lenon, Rahman, Aminur, Ai, Zhibing, Bai, Fanghui, Duan, Zhenhui, Hao, Yonggang, Huang, Wenguo, Li, Guangwen, Li, Wei, Liu, Ganzhe, Luo, Jun, Shang, Xianjin, Sui, Yi, Tian, Ling, Wen, Hongbin, Wu, Bo, Yan, Yuying, Yuan, Zhengzhou, Zhang, Hao, Zhang, Jun, Zhao, Wenlong, Zi, Wenjie, Leung, Thomas K., Sahakyan, David, Chugh, Chandril, Huded, Vikram, Menon, Bindu, Pandian, Jeyaraj, Sylaja, P. N., Usman, Fritz Sumantri, Farhoudi, Mehdi, Sadeghi-Hokmabadi, Elyar, Reznik, Anna, Sivan-Hoffman, Rotem, Horev, Anat, Ohara, Nobuyuki, Sakai, Nobuyuki, Watanabe, Daisuke, Yamamoto, Ryoo, Doijiri, Ryosuke, Tokuda, Naoki, Yamada, Takehiro, Terasaki, Tadashi, Yazawa, Yukako, Uwatoko, Takeshi, Dembo, Tomohisa, Shimizu, Hisao, Sugiura, Yuri, Miyashita, Fumio, Fukuda, Hiroki, Miyake, Kosuke, Shimbo, Junsuke, Sugimura, Yusuke, Yagita, Yoshika, Takenobu, Yohei, Matsumaru, Yuji, Yamada, Satoshi, Kono, Ryuhei, Kanamaru, Takuya, Yamazaki, Hidekazu, Sakaguchi, Manabu, Todo, Kenichi, Yamamoto, Nobuaki, Sonodda, Kazutaka, Yoshida, Tomoko, Hashimoto, Hiroyuki, Nakahara, Ichiro, Faizullina, Kamila, Kamenova, Saltanat, Kondybayeva, Aida, Zhanuzakov, Murat, Baek, Jang-Hyun, Hwang, Yangha, Lee, Si Baek, Moon, Jusun, Park, Hyungjong, Seo, Jung Hwa, Seo, Kwon-Duk, Young, Chang Jun, Ahdab, Rechdi, Aziz, Zariah Abdul, Zaidi, Wan Asyraf Wan, Bin Basri, Hamidon, Chung, Law Wan, Husin, Mazlina, Ibrahim, Aznita Binti, Ibrahim, Khairul Azmi, Looi, Irene, Tan, Wee Yong, Yahya, Wan Nur Nafisah Wan, Groppa, Stanislav, Leahu, Pavel, Al Hashmi, Amal, Imam, Yehai Z., Akhtar, Naveed, Oliver, Christian, Kandyba, Dmitriy, Alhazzani, Adel, Al-Jehani, Hosam, Tham, Carol Huilian, Mamauag, Marlie Jane, Narayanaswamy, Ram, Chen, Chih-Hao, Tang, Sung-Chun, Churojana, Anchalee, Aykac, Ozlem, Ozdemir, Atilla Ozcan, Hussain, Syed Irteza, John, Seby, Huynh Le Vu, Anh Duc Tran, Huy Hoang Nguyen, Pham Nhu Thong, Nguyen, Thang, Nguyen, Trung, Gattringer, Thomas, Enzinger, Christian, Killer-Oberpfalzer, Monika, Bellante, Flavio, De Blauwe, Sofie, Van Hooren, Geert, De Raedt, Sylvie, Dusart, Anne, Ligot, Noemie, Rutgers, Matthieu, Yperzeele, Laetitia, Alexiev, Filip, Sakelarova, Teodora, Bedekovic, Marina Roje, Budincevic, Hrvoje, Cindric, Igor, Hucika, Zlatko, Ozretic, David, Saric, Majda Seferovic, Pfeifer, Frantisek, Karpowicz, Igor, Cernik, David, Sramek, Martin, Skoda, Miroslav, Hlavacova, Helena, Klecka, Lukas, Koutny, Martin, Vaclavik, Dan, Skoda, Ondrej, Fiksa, Jan, Hanelova, Katerina, Nevsimalova, Miroslava, Rezek, Robert, Prochazka, Petr, Krejstova, Gabriela, Neumann, Jiri, Vachova, Marta, Brzezanski, Henry, Hlinovsky, David, Tenora, Dusan, Jura, Rene, Jurak, Lubomir, Novak, Jan, Novak, Ales, Topinka, Zdenek, Fibrich, Petr, Sobolova, Helena, Volny, Ondrej, Christensen, Hanne Krarup, Drenck, Nicolas, Iversen, Helle, Simonsen, Claus, Truelsen, Thomas, Wienecke, Troels, Vibo, Riina, Gross-Paju, Katrin, Toomsoo, Toomas, Antsov, Katrin, Caparros, Francois, Cordonnier, Charlotte, Dan, Maria, Faucheux, Jean-Marc, Mechtouff, Laura, Eker, Omer, Lesaine, Emillie, Ondze, Basile, Pico, Fernando, Pop, Raoul, Rouanet, Francois, Gubeladze, Tatuli, Khinikadze, Mirza, Lobjanidze, Nina, Tsiskaridze, Alexander, Nagel, Simon, Ringleb, Peter Arthur, Rosenkranz, Michael, Schmidt, Holger, Sedghi, Annahita, Siepmann, Timo, Szabo, Kristina, Thomalla, Gotz, Palaiodimou, Lina, Sagris, Dimitrios, Kargiotis, Odysseas, Kaliaev, Artem, Liebeskind, David, Hassan, Ameer, Ranta, Anna, Devlin, Thomas, Zaidat, Osama, Castonguay, Alicia, Jovin, Tudor, Tsivgoulis, Georgios, Malik, Amer, Ma, Alice, Campbell, Bruce, Kleinig, Timothy, Wu, Teddy, Gongora, Fernando, Lavados, Pablo, Olavarria, Veronica, Lereis, Virginia Pujol, Corredor, Angel, Barbosa, Diana Mantilla, Bayona, Hernan, Barrientos, Jose Domingo, Patino, Mauricio, Thijs, Vincent, Pirson, Anne, Kristoffersen, Espen Saxhaug, Patrik, Michel, Fischer, Urs, Bernava, Gianmarco, Renieri, Leonardo, Strambo, Davide, Ayo-Martin, Oscar, Montaner, Joan, Karlinski, Michal, Cruz-Culebras, Antonio, Luchowski, Piotr, Krastev, Georgi, Arenillas, Juan, Gralla, Jan, Mangiafico, Salvatore, Blasco, Jordi, Fonseca, Luisa, Silva, M. Luis, Kwan, Joseph, Banerjee, Soma, Sangalli, Davide, Frisullo, Giovanni, Yavagal, Dileep, Uyttenboogaart, Maarten, Bandini, Fabio, Adami, Alessandro, de Lecina, Maria Alonso, Arribas, Miguel Angel Tola, Ferreira, Paulo, Cruz, Vitor Tedim, Nunes, Ana Paiva, Marto, Joao Pedro, Rodrigues, Miguel, Melo, Teresa, Saposnik, Gustavo, Scott, Courtney Anne, Shuaib, Ashfaq, Khosravani, Houman, Fields, Thalia, Shoamanesh, Ashkan, Catanese, Luciana, Mackey, Ariane, Hill, Michael, Etherton, Mark, Rost, Natalia, Lutsep, Helmi, Lee, Vivien, Mehta, Brijesh, Pikula, Aleksandra, Simmons, Marc, Macdougall, Lisa, Silver, Brian, Khandelwal, Priyank, Morris, Jane, Novakovic-White, Roberta, Ramakrishnan, Pankajavalli, Shah, Ruchir, Altschul, Dorothea, Almufti, Fawaz, Amaya, Pablo, Ordonez, Carlos Eduardo Rivera, Lara, Osvalda, Kadota, Liliana Rodriguez, Rivera, Ligia Ibeth Portillo, Novarro, Nelson, Escobar, Luis Diaz, Melgarejo, Donoband, Cardozo, Analia, Blanco, Anmylene, Zelaya, Javier Adolfo, Luraschi, Adriana, Gonzalez, Victor Hugo Navia, Almeida, Juan, Conforto, Adriana, Almeida, Marcele Schettini, Silva, Leonardo de Deus, Cuervo, Daissy Liliana Mora, Zetola, Viviane Flumignan, Martins, Rodrigo Targa, Valler, Lenise, Giacomini, Luidia Varrone, Cardoso, Fabricio Buchdid, Sahathevan, Ramesh, Hair, Casey, Hankey, Graeme, Salazar, Daniel, Lima, Fabricio Oliveira, Mont'Alverne, Francisco, Moises, Danny, Iman, Barrientos, Magalhaes, Pedro, Longo, Alexandre, Rebello, Leticia, Falup-Pecurariu, Cristian, Mazya, Michael, Wisniewska, Anna, Fryze, Waldemar, Kazmierski, Radoslaw, Wisniewska, Malgorzata, Horoch, Ewa, Sienkiewicz-Jarosz, Halina, Fudala, Malgorzata, Rogoziewicz, Marcin, Brola, Waldemar, Sobolewski, Piotr, Kaczorowski, Rafal, Stepien, Adam, Klivenyi, Peter, Szapary, Laszlo, van den Wijngaard, Ido, Demchuk, Andrew, Abraham, Michael, Alvarado-Ortiz, Tony, Kaushal, Ritesh, Ortega-Gutierrez, Santiago, Farooqui, Mudassir, Bach, Ivo, Badruddin, Aamir, Barazangi, Nobl, Nguyen, Claude, Brereton, Charmaine, Choi, Jae H., Dharmadhikari, Sushrut, Desai, Kinjal, Doss, Vinodh, Edgell, Randall, Linares, Guillermo, Frei, Donald, Chaturvedi, Seemant, Gandhi, Dheeraj, Chaudhry, Saqib, Choe, Hana, Grigoryan, Mikayel, Gupta, Rishi, Helenius, Johanna, Voetsch, Barbara, Khwaja, Ayaz, Khoury, Naim, Kim, Benny S., Kleindorfer, Dawn, McDermott, Molly, Koyfman, Feliks, Leung, Lester, Linfante, Italo, Male, Shailesh, Masoud, Hesham, Min, Jiangyong, Mittal, Manoj, Multani, Sumeet, Nahab, Fadi, Nalleballe, Krishna, Rahangdale, Rahul, Rafael, Jose, Rothstein, Aaron, Ruland, Sean, Sharma, Malveeka, Singh, Abishek, Starosciak, Amy, Strasser, Sheryl, Szeder, Viktor, Teleb, Mohamed, Tsai, Jenny, Mohammaden, Mahmoud, Pineda-Franks, Carissa, Asyraf, Wan, Trung Quoch Nguyen, Tarkanyi, Gabor, Haussen, Diogo, Balaguera, Oscar, Vasquez, Alejandro Rodriguez, Nogueira, Raul, Thanh Nguyen, Phuong, Qureshi, Muhammad, Martins, Sheila, Yamagami, Hiroshi, Qiu, Zhongming, Mansour, Ossama, Czlonkowska, Anna, Abdalkader, Mohamad, Sathya, Anvitha, de Sousa, Diana Aguiar, Demeestere, Jelle, Mikulik, Robert, Vanacker, Peter, Siegler, James, Korv, Janika, Biller, Jose, Liang, Conrad, Sangha, Navdeep, Zha, Alicia, Czap, Alexandra, Holmstedt, Christine, Turan, Tanya, Grant, Cheryl, Ntaios, George, Malhotra, Konard, Tayal, Ashis, Loochtan, Aaron, Mistry, Eva, Alexandrov, Anne, Huang, David, Yaghi, Shadi, Raz, Eytan, Sheth, Sunil, Frankel, Michael, Lamou, Eric Gueumekane Bila, Aref, Hany, Elbassiouny, Ahmed, Hassan, Farouk, Mustafa, Wessam, Menecie, Tarek, Shokri, Hossam, Roushdy, Tamer, Sarfo, Fred Stephen, Alabi, Tolulope, Arabambi, Babawale, Nwazor, Ernest, Sunmonu, Taofiki Ajao, Wahab, Kolawole W., Mohammed, Haythem Hussein, Adebayo, Philip B., Riahi, Anis, Ben Sassi, Samia, Gwaunza, Lenon, Rahman, Aminur, Ai, Zhibing, Bai, Fanghui, Duan, Zhenhui, Hao, Yonggang, Huang, Wenguo, Li, Guangwen, Li, Wei, Liu, Ganzhe, Luo, Jun, Shang, Xianjin, Sui, Yi, Tian, Ling, Wen, Hongbin, Wu, Bo, Yan, Yuying, Yuan, Zhengzhou, Zhang, Hao, Zhang, Jun, Zhao, Wenlong, Zi, Wenjie, Leung, Thomas K., Sahakyan, David, Chugh, Chandril, Huded, Vikram, Menon, Bindu, Pandian, Jeyaraj, Sylaja, P. N., Usman, Fritz Sumantri, Farhoudi, Mehdi, Sadeghi-Hokmabadi, Elyar, Reznik, Anna, Sivan-Hoffman, Rotem, Horev, Anat, Ohara, Nobuyuki, Sakai, Nobuyuki, Watanabe, Daisuke, Yamamoto, Ryoo, Doijiri, Ryosuke, Tokuda, Naoki, Yamada, Takehiro, Terasaki, Tadashi, Yazawa, Yukako, Uwatoko, Takeshi, Dembo, Tomohisa, Shimizu, Hisao, Sugiura, Yuri, Miyashita, Fumio, Fukuda, Hiroki, Miyake, Kosuke, Shimbo, Junsuke, Sugimura, Yusuke, Yagita, Yoshika, Takenobu, Yohei, Matsumaru, Yuji, Yamada, Satoshi, Kono, Ryuhei, Kanamaru, Takuya, Yamazaki, Hidekazu, Sakaguchi, Manabu, Todo, Kenichi, Yamamoto, Nobuaki, Sonodda, Kazutaka, Yoshida, Tomoko, Hashimoto, Hiroyuki, Nakahara, Ichiro, Faizullina, Kamila, Kamenova, Saltanat, Kondybayeva, Aida, Zhanuzakov, Murat, Baek, Jang-Hyun, Hwang, Yangha, Lee, Si Baek, Moon, Jusun, Park, Hyungjong, Seo, Jung Hwa, Seo, Kwon-Duk, Young, Chang Jun, Ahdab, Rechdi, Aziz, Zariah Abdul, Zaidi, Wan Asyraf Wan, Bin Basri, Hamidon, Chung, Law Wan, Husin, Mazlina, Ibrahim, Aznita Binti, Ibrahim, Khairul Azmi, Looi, Irene, Tan, Wee Yong, Yahya, Wan Nur Nafisah Wan, Groppa, Stanislav, Leahu, Pavel, Al Hashmi, Amal, Imam, Yehai Z., Akhtar, Naveed, Oliver, Christian, Kandyba, Dmitriy, Alhazzani, Adel, Al-Jehani, Hosam, Tham, Carol Huilian, Mamauag, Marlie Jane, Narayanaswamy, Ram, Chen, Chih-Hao, Tang, Sung-Chun, Churojana, Anchalee, Aykac, Ozlem, Ozdemir, Atilla Ozcan, Hussain, Syed Irteza, John, Seby, Huynh Le Vu, Anh Duc Tran, Huy Hoang Nguyen, Pham Nhu Thong, Nguyen, Thang, Nguyen, Trung, Gattringer, Thomas, Enzinger, Christian, Killer-Oberpfalzer, Monika, Bellante, Flavio, De Blauwe, Sofie, Van Hooren, Geert, De Raedt, Sylvie, Dusart, Anne, Ligot, Noemie, Rutgers, Matthieu, Yperzeele, Laetitia, Alexiev, Filip, Sakelarova, Teodora, Bedekovic, Marina Roje, Budincevic, Hrvoje, Cindric, Igor, Hucika, Zlatko, Ozretic, David, Saric, Majda Seferovic, Pfeifer, Frantisek, Karpowicz, Igor, Cernik, David, Sramek, Martin, Skoda, Miroslav, Hlavacova, Helena, Klecka, Lukas, Koutny, Martin, Vaclavik, Dan, Skoda, Ondrej, Fiksa, Jan, Hanelova, Katerina, Nevsimalova, Miroslava, Rezek, Robert, Prochazka, Petr, Krejstova, Gabriela, Neumann, Jiri, Vachova, Marta, Brzezanski, Henry, Hlinovsky, David, Tenora, Dusan, Jura, Rene, Jurak, Lubomir, Novak, Jan, Novak, Ales, Topinka, Zdenek, Fibrich, Petr, Sobolova, Helena, Volny, Ondrej, Christensen, Hanne Krarup, Drenck, Nicolas, Iversen, Helle, Simonsen, Claus, Truelsen, Thomas, Wienecke, Troels, Vibo, Riina, Gross-Paju, Katrin, Toomsoo, Toomas, Antsov, Katrin, Caparros, Francois, Cordonnier, Charlotte, Dan, Maria, Faucheux, Jean-Marc, Mechtouff, Laura, Eker, Omer, Lesaine, Emillie, Ondze, Basile, Pico, Fernando, Pop, Raoul, Rouanet, Francois, Gubeladze, Tatuli, Khinikadze, Mirza, Lobjanidze, Nina, Tsiskaridze, Alexander, Nagel, Simon, Ringleb, Peter Arthur, Rosenkranz, Michael, Schmidt, Holger, Sedghi, Annahita, Siepmann, Timo, Szabo, Kristina, Thomalla, Gotz, Palaiodimou, Lina, Sagris, Dimitrios, Kargiotis, Odysseas, Kaliaev, Artem, Liebeskind, David, Hassan, Ameer, Ranta, Anna, Devlin, Thomas, Zaidat, Osama, Castonguay, Alicia, Jovin, Tudor, Tsivgoulis, Georgios, Malik, Amer, Ma, Alice, Campbell, Bruce, Kleinig, Timothy, Wu, Teddy, Gongora, Fernando, Lavados, Pablo, Olavarria, Veronica, Lereis, Virginia Pujol, Corredor, Angel, Barbosa, Diana Mantilla, Bayona, Hernan, Barrientos, Jose Domingo, Patino, Mauricio, Thijs, Vincent, Pirson, Anne, Kristoffersen, Espen Saxhaug, Patrik, Michel, Fischer, Urs, Bernava, Gianmarco, Renieri, Leonardo, Strambo, Davide, Ayo-Martin, Oscar, Montaner, Joan, Karlinski, Michal, Cruz-Culebras, Antonio, Luchowski, Piotr, Krastev, Georgi, Arenillas, Juan, Gralla, Jan, Mangiafico, Salvatore, Blasco, Jordi, Fonseca, Luisa, Silva, M. Luis, Kwan, Joseph, Banerjee, Soma, Sangalli, Davide, Frisullo, Giovanni, Yavagal, Dileep, Uyttenboogaart, Maarten, Bandini, Fabio, Adami, Alessandro, de Lecina, Maria Alonso, Arribas, Miguel Angel Tola, Ferreira, Paulo, Cruz, Vitor Tedim, Nunes, Ana Paiva, Marto, Joao Pedro, Rodrigues, Miguel, Melo, Teresa, Saposnik, Gustavo, Scott, Courtney Anne, Shuaib, Ashfaq, Khosravani, Houman, Fields, Thalia, Shoamanesh, Ashkan, Catanese, Luciana, Mackey, Ariane, Hill, Michael, Etherton, Mark, Rost, Natalia, Lutsep, Helmi, Lee, Vivien, Mehta, Brijesh, Pikula, Aleksandra, Simmons, Marc, Macdougall, Lisa, Silver, Brian, Khandelwal, Priyank, Morris, Jane, Novakovic-White, Roberta, Ramakrishnan, Pankajavalli, Shah, Ruchir, Altschul, Dorothea, Almufti, Fawaz, Amaya, Pablo, Ordonez, Carlos Eduardo Rivera, Lara, Osvalda, Kadota, Liliana Rodriguez, Rivera, Ligia Ibeth Portillo, Novarro, Nelson, Escobar, Luis Diaz, Melgarejo, Donoband, Cardozo, Analia, Blanco, Anmylene, Zelaya, Javier Adolfo, Luraschi, Adriana, Gonzalez, Victor Hugo Navia, Almeida, Juan, Conforto, Adriana, Almeida, Marcele Schettini, Silva, Leonardo de Deus, Cuervo, Daissy Liliana Mora, Zetola, Viviane Flumignan, Martins, Rodrigo Targa, Valler, Lenise, Giacomini, Luidia Varrone, Cardoso, Fabricio Buchdid, Sahathevan, Ramesh, Hair, Casey, Hankey, Graeme, Salazar, Daniel, Lima, Fabricio Oliveira, Mont'Alverne, Francisco, Moises, Danny, Iman, Barrientos, Magalhaes, Pedro, Longo, Alexandre, Rebello, Leticia, Falup-Pecurariu, Cristian, Mazya, Michael, Wisniewska, Anna, Fryze, Waldemar, Kazmierski, Radoslaw, Wisniewska, Malgorzata, Horoch, Ewa, Sienkiewicz-Jarosz, Halina, Fudala, Malgorzata, Rogoziewicz, Marcin, Brola, Waldemar, Sobolewski, Piotr, Kaczorowski, Rafal, Stepien, Adam, Klivenyi, Peter, Szapary, Laszlo, van den Wijngaard, Ido, Demchuk, Andrew, Abraham, Michael, Alvarado-Ortiz, Tony, Kaushal, Ritesh, Ortega-Gutierrez, Santiago, Farooqui, Mudassir, Bach, Ivo, Badruddin, Aamir, Barazangi, Nobl, Nguyen, Claude, Brereton, Charmaine, Choi, Jae H., Dharmadhikari, Sushrut, Desai, Kinjal, Doss, Vinodh, Edgell, Randall, Linares, Guillermo, Frei, Donald, Chaturvedi, Seemant, Gandhi, Dheeraj, Chaudhry, Saqib, Choe, Hana, Grigoryan, Mikayel, Gupta, Rishi, Helenius, Johanna, Voetsch, Barbara, Khwaja, Ayaz, Khoury, Naim, Kim, Benny S., Kleindorfer, Dawn, McDermott, Molly, Koyfman, Feliks, Leung, Lester, Linfante, Italo, Male, Shailesh, Masoud, Hesham, Min, Jiangyong, Mittal, Manoj, Multani, Sumeet, Nahab, Fadi, Nalleballe, Krishna, Rahangdale, Rahul, Rafael, Jose, Rothstein, Aaron, Ruland, Sean, Sharma, Malveeka, Singh, Abishek, Starosciak, Amy, Strasser, Sheryl, Szeder, Viktor, Teleb, Mohamed, Tsai, Jenny, Mohammaden, Mahmoud, Pineda-Franks, Carissa, Asyraf, Wan, Trung Quoch Nguyen, Tarkanyi, Gabor, Haussen, Diogo, Balaguera, Oscar, Vasquez, Alejandro Rodriguez, and Nogueira, Raul

Published
2021

27. Global impact of the COVID-19 pandemic on stroke care and intravenous thrombolysis (1462)

Author

Nguyen, Thanh, primary, Qureshi, Muhammad, additional, Martins, Sheila, additional, Yamagami, Hiroshi, additional, Qiu, Zhongming, additional, Mansour, Ossama, additional, Czlonkowska, Anna, additional, Abdalkader, Mohamad, additional, Sathya, Anvitha, additional, de Sousa, Diana Aguiar, additional, Demeestere, Jelle, additional, Mikulik, Robert, additional, Vanacker, Peter, additional, Siegler, James, additional, Korv, Janika, additional, Biller, Jose, additional, Liang, Conrad, additional, Sangha, Navdeep, additional, Zha, Alicia, additional, Czap, Alexandra, additional, Holmstedt, Christine, additional, Turan, Tanya, additional, Grant, Cheryl, additional, Ntaios, George, additional, Malhotra, Konard, additional, Tayal, Ashis, additional, Loochtan, Aaron, additional, Mistry, Eva, additional, Alexandrov, Anne, additional, Huang, David, additional, Yaghi, Shadi, additional, Raz, Eytan, additional, Sheth, Sunil, additional, Frankel, Michael, additional, Lamou, Eric Gueumekane Bila, additional, Aref, Hany, additional, Elbassiouny, Ahmed, additional, Hassan, Farouk, additional, Mustafa, Wessam, additional, Menecie, Tarek, additional, Shokri, Hossam, additional, Roushdy, Tamer, additional, Sarfo, Fred Stephen, additional, Alabi, Tolulope, additional, Arabambi, Babawale, additional, Nwazor, Ernest, additional, Sunmonu, Taofiki Ajao, additional, Wahab, Kolawole W., additional, Mohammed, Haythem Hussein, additional, Adebayo, Philip B., additional, Riahi, Anis, additional, Ben Sassi, Samia, additional, Gwaunza, Lenon, additional, Rahman, Aminur, additional, Ai, Zhibing, additional, Bai, Fanghui, additional, Duan, Zhenhui, additional, Hao, Yonggang, additional, Huang, Wenguo, additional, Li, Guangwen, additional, Li, Wei, additional, Liu, Ganzhe, additional, Luo, Jun, additional, Shang, Xianjin, additional, Sui, Yi, additional, Tian, Ling, additional, Wen, Hongbin, additional, Wu, Bo, additional, Yan, Yuying, additional, Yuan, Zhengzhou, additional, Zhang, Hao, additional, Zhang, Jun, additional, Zhao, Wenlong, additional, Zi, Wenjie, additional, Leung, Thomas K., additional, Sahakyan, David, additional, Chugh, Chandril, additional, Huded, Vikram, additional, Menon, Bindu, additional, Pandian, Jeyaraj, additional, Sylaja, P.N., additional, Usman, Fritz Sumantri, additional, Farhoudi, Mehdi, additional, Sadeghi-Hokmabadi, Elyar, additional, Reznik, Anna, additional, Sivan-Hoffman, Rotem, additional, Horev, Anat, additional, Ohara, Nobuyuki, additional, Sakai, Nobuyuki, additional, Watanabe, Daisuke, additional, Yamamoto, Ryoo, additional, Doijiri, Ryosuke, additional, Tokuda, Naoki, additional, Yamada, Takehiro, additional, Terasaki, Tadashi, additional, Yazawa, Yukako, additional, Uwatoko, Takeshi, additional, Dembo, Tomohisa, additional, Shimizu, Hisao, additional, Sugiura, Yuri, additional, Miyashita, Fumio, additional, Fukuda, Hiroki, additional, Miyake, Kosuke, additional, Shimbo, Junsuke, additional, Sugimura, Yusuke, additional, Yagita, Yoshika, additional, Takenobu, Yohei, additional, Matsumaru, Yuji, additional, Yamada, Satoshi, additional, Kono, Ryuhei, additional, Kanamaru, Takuya, additional, Yamazaki, Hidekazu, additional, Sakaguchi, Manabu, additional, Todo, Kenichi, additional, Yamamoto, Nobuaki, additional, Sonodda, Kazutaka, additional, Yoshida, Tomoko, additional, Hashimoto, Hiroyuki, additional, Nakahara, Ichiro, additional, Faizullina, Kamila, additional, Kamenova, Saltanat, additional, Kondybayeva, Aida, additional, Zhanuzakov, Murat, additional, Baek, Jang-Hyun, additional, Hwang, Yangha, additional, Lee, Si Baek, additional, Moon, Jusun, additional, Park, Hyungjong, additional, Seo, Jung Hwa, additional, Seo, Kwon-Duk, additional, Young, Chang Jun, additional, Ahdab, Rechdi, additional, Aziz, Zariah Abdul, additional, Zaidi, Wan Asyraf Wan, additional, Basri, Hamidon Bin, additional, Chung, Law Wan, additional, Husin, Mazlina, additional, Ibrahim, Aznita Binti, additional, Ibrahim, Khairul Azmi, additional, Looi, Irene, additional, Tan, Wee Yong, additional, Yahya, Wan Nur Nafisah Wan, additional, Groppa, Stanislav, additional, Leahu, Pavel, additional, Al Hashmi, Amal, additional, Imam, Yehai Z., additional, Akhtar, Naveed, additional, Oliver, Christian, additional, Kandyba, Dmitriy, additional, Alhazzani, Adel, additional, Al-Jehani, Hosam, additional, Tham, Carol Huilian, additional, Mamauag, Marlie Jane, additional, Narayanaswamy, Ram, additional, Chen, Chih-Hao, additional, Tang, Sung-Chun, additional, Churojana, Anchalee, additional, Aykaç, Ozlem, additional, Özdemir, Atilla Özcan, additional, Hussain, Syed Irteza, additional, John, Seby, additional, Le Vu, Huynh, additional, Tran, Anh Duc, additional, Nguyen, Huy Hoang, additional, Thong, Pham Nhu, additional, Nguyen, Thang, additional, Nguyen, Trung, additional, Gattringer, Thomas, additional, Enzinger, Christian, additional, Killer-Oberpfalzer, Monika, additional, Bellante, Flavio, additional, De Blauwe, Sofie, additional, Van Hooren, Geert, additional, De Raedt, Sylvie, additional, Dusart, Anne, additional, Ligot, Noemie, additional, Rutgers, Matthieu, additional, Yperzeele, Laetitia, additional, Alexiev, Filip, additional, Sakelarova, Teodora, additional, Bedekovic, Marina Roje, additional, Budincevic, Hrvoje, additional, Cindric, Igor, additional, Hucika, Zlatko, additional, Ozretic, David, additional, Saric, Majda Seferovic, additional, Pfeifer, František, additional, Karpowicz, Igor, additional, Cernik, David, additional, Sramek, Martin, additional, Skoda, Miroslav, additional, Hlavacova, Helena, additional, Klecka, Lukas, additional, Koutny, Martin, additional, Vaclavik, Dan, additional, Skoda, Ondrej, additional, Fiksa, Jan, additional, Hanelova, Katerina, additional, Nevsimalova, Miroslava, additional, Rezek, Robert, additional, Prochazka, Petr, additional, Krejstova, Gabriela, additional, Neumann, Jiri, additional, Vachova, Marta, additional, Brzezanski, Henry, additional, Hlinovsky, David, additional, Tenora, Dusan, additional, Jura, Rene, additional, Jurak, Lubomir, additional, Novak, Jan, additional, Novak, Ales, additional, Topinka, Zdenek, additional, Fibrich, Petr, additional, Sobolova, Helena, additional, Volny, Ondrej, additional, Christensen, Hanne Krarup, additional, Drenck, Nicolas, additional, Iversen, Helle, additional, Simonsen, Claus, additional, Truelsen, Thomas, additional, Wienecke, Troels, additional, Vibo, Riina, additional, Gross-Paju, Katrin, additional, Toomsoo, Toomas, additional, Antsov, Katrin, additional, Caparros, Francois, additional, Cordonnier, Charlotte, additional, Dan, Maria, additional, Faucheux, Jean-Marc, additional, Mechtouff, Laura, additional, Eker, Omer, additional, Lesaine, Emillie, additional, Ondze, Basile, additional, Pico, Fernando, additional, Pop, Raoul, additional, Rouanet, Francois, additional, Gubeladze, Tatuli, additional, Khinikadze, Mirza, additional, Lobjanidze, Nina, additional, Tsiskaridze, Alexander, additional, Nagel, Simon, additional, Ringleb, Peter Arthur, additional, Rosenkranz, Michael, additional, Schmidt, Holger, additional, Sedghi, Annahita, additional, Siepmann, Timo, additional, Szabo, Kristina, additional, Thomalla, Gotz, additional, Palaiodimou, Lina, additional, Sagris, Dimitrios, additional, Kargiotis, Odysseas, additional, Kaliaev, Artem, additional, Liebeskind, David, additional, Hassan, Ameer, additional, Ranta, Anna, additional, Devlin, Thomas, additional, Zaidat, Osama, additional, Castonguay, Alicia, additional, Jovin, Tudor, additional, Tsivgoulis, Georgios, additional, Malik, Amer, additional, Ma, Alice, additional, Campbell, Bruce, additional, Kleinig, Timothy, additional, Wu, Teddy, additional, Gongora, Fernando, additional, Lavados, Pablo, additional, Olavarria, Veronica, additional, Lereis, Virginia Pujol, additional, Corredor, Angel, additional, Barbosa, Diana Mantilla, additional, Bayona, Hernan, additional, Barrientos, Jose Domingo, additional, Patino, Mauricio, additional, Thijs, Vincent, additional, Pirson, Anne, additional, Kristoffersen, Espen Saxhaug, additional, Patrik, Michel, additional, Fischer, Urs, additional, Bernava, Gianmarco, additional, Renieri, Leonardo, additional, Strambo, Davide, additional, Ayo-Martin, Oscar, additional, Montaner, Joan, additional, Karlinski, Michal, additional, Cruz-Culebras, Antonio, additional, Luchowski, Piotr, additional, Krastev, Georgi, additional, Arenillas, Juan, additional, Gralla, Jan, additional, Mangiafico, Salvatore, additional, Blasco, Jordi, additional, Fonseca, Luisa, additional, Silva, M. Luis, additional, Kwan, Joseph, additional, Banerjee, Soma, additional, Sangalli, Davide, additional, Frisullo, Giovanni, additional, Yavagal, Dileep, additional, Uyttenboogaart, Maarten, additional, Bandini, Fabio, additional, Adami, Alessandro, additional, de Lecina, Maria Alonso, additional, Arribas, Miguel Angel Tola, additional, Ferreira, Paulo, additional, Cruz, Vitor Tedim, additional, Nunes, Ana Paiva, additional, Marto, Joao Pedro, additional, Rodrigues, Miguel, additional, Melo, Teresa, additional, Saposnik, Gustavo, additional, Scott, Courtney Anne, additional, Shuaib, Ashfaq, additional, Khosravani, Houman, additional, Fields, Thalia, additional, Shoamanesh, Ashkan, additional, Catanese, Luciana, additional, Mackey, Ariane, additional, Hill, Michael, additional, Etherton, Mark, additional, Rost, Natalia, additional, Lutsep, Helmi, additional, Lee, Vivien, additional, Mehta, Brijesh, additional, Pikula, Aleksandra, additional, Simmons, Marc, additional, Macdougall, Lisa, additional, Silver, Brian, additional, Khandelwal, Priyank, additional, Morris, Jane, additional, Novakovic-White, Roberta, additional, Ramakrishnan, Pankajavalli, additional, Shah, Ruchir, additional, Altschul, Dorothea, additional, Almufti, Fawaz, additional, Amaya, Pablo, additional, Ordonez, Carlos Eduardo Rivera, additional, Lara, Osvalda, additional, Kadota, Liliana Rodriguez, additional, Rivera, Ligia Ibeth Portillo, additional, Novarro, Nelson, additional, Escobar, Luis Diaz, additional, Melgarejo, Donoband, additional, Cardozo, Analia, additional, Blanco, Anmylene, additional, Zelaya, Javier Adolfo, additional, Luraschi, Adriana, additional, Gonzalez, Victor Hugo Navia, additional, Almeida, Juan, additional, Conforto, Adriana, additional, Almeida, Marcele Schettini, additional, de Deus Silva, Leonardo, additional, Cuervo, Daissy Liliana Mora, additional, Zetola, Viviane Flumignan, additional, Martins, Rodrigo Targa, additional, Valler, Lenise, additional, Giacomini, Luidia Varrone, additional, Cardoso, Fabricio Buchdid, additional, Sahathevan, Ramesh, additional, Hair, Casey, additional, Hankey, Graeme, additional, Salazar, Daniel, additional, Lima, Fabricio Oliveira, additional, Mont’Alverne, Francisco, additional, Iman, Danny Moises Barrientos, additional, Magalhaes, Pedro, additional, Longo, Alexandre, additional, Rebello, Leticia, additional, Falup-Pecurariu, Cristian, additional, Mazya, Michael, additional, Wisniewska, Anna, additional, Fryze, Waldemar, additional, Kazmierski, Radoslaw, additional, Wisniewska, Malgorzata, additional, Horoch, Ewa, additional, Sienkiewicz-Jarosz, Halina, additional, Fudala, Malgorzata, additional, Rogoziewicz, Marcin, additional, Brola, Waldemar, additional, Sobolewski, Piotr, additional, Kaczorowski, Rafal, additional, Stepien, Adam, additional, Klivenyi, Peter, additional, Szapary, Laszlo, additional, van den Wijngaard, Ido, additional, Demchuk, Andrew, additional, Abraham, Michael, additional, Alvarado-Ortiz, Tony, additional, Kaushal, Ritesh, additional, Ortega-Gutierrez, Santiago, additional, Farooqui, Mudassir, additional, Bach, Ivo, additional, Badruddin, Aamir, additional, Barazangi, Nobl, additional, Nguyen, Claude, additional, Brereton, Charmaine, additional, Choi, Jae H., additional, Dharmadhikari, Sushrut, additional, Desai, Kinjal, additional, Doss, Vinodh, additional, Edgell, Randall, additional, Linares, Guillermo, additional, Frei, Donald, additional, Chaturvedi, Seemant, additional, Gandhi, Dheeraj, additional, Chaudhry, Saqib, additional, Choe, Hana, additional, Grigoryan, Mikayel, additional, Gupta, Rishi, additional, Helenius, Johanna, additional, Voetsch, Barbara, additional, Khwaja, Ayaz, additional, Khoury, Naim, additional, Kim, Benny S., additional, Kleindorfer, Dawn, additional, McDermott, Molly, additional, Koyfman, Feliks, additional, Leung, Lester, additional, Linfante, Italo, additional, Male, Shailesh, additional, Masoud, Hesham, additional, Min, Jiangyong, additional, Mittal, Manoj, additional, Multani, Sumeet, additional, Nahab, Fadi, additional, Nalleballe, Krishna, additional, Rahangdale, Rahul, additional, Rafael, Jose, additional, Rothstein, Aaron, additional, Ruland, Sean, additional, Sharma, Malveeka, additional, Singh, Abishek, additional, Starosciak, Amy, additional, Strasser, Sheryl, additional, Szeder, Viktor, additional, Teleb, Mohamed, additional, Tsai, Jenny, additional, Mohammaden, Mahmoud, additional, Pineda-Franks, Carissa, additional, Asyraf, Wan, additional, Nguyen, Trung QuocH, additional, Tarkanyi, Gabor, additional, Haussen, Diogo, additional, Balaguera, Oscar, additional, Vasquez, Alejandro Rodriguez, additional, and Nogueira, Raul, additional

Published
2021
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31. 4-1BB-mediated immunotherapy of rheumatoid arthritis

Author

Seo, Su K, Choi, Jae H, Kim, Young H, Kang, Woo J, Park, Hye Y, Suh, Jae H, Choi, Beom K, Vinay, Dass S, and Kwon, Byoung S

Abstract

Collagen type II-induced arthritis is a CD4[sup.+] T-cell-dependent chronic inflammation in susceptible DBA/1 mice and represents an animal model of human rheumatoid arthritis. We found that development of this condition, and even established disease, are inhibited by an agonistic anti-4-1BB monoclonal antibody. Anti-4-1BB suppressed serum antibodies to collagen type II and CD4[sup.+] T-cell recall responses to collagen type II. Crosslinking of 4-1BB evoked an antigen-specific, active suppression mechanism that differed from the results of blocking the interaction between 4-1BB and its ligand, 4-1BBL. Anti-4-1BB monoclonal antibodies induced massive, antigen-dependent clonal expansion of CD11c[sup.+]CD8[sup.+] T cells and accumulation of indoleamine 2,3-dioxygenase in CD11b[sup.+] monocytes and CD11c[sup.+] dendritic cells. Both anti-interferon-[gamma] and 1-methyltryptophan, a pharmacological inhibitor of indoleamine 2,3-dioxygenase, reversed the anti-4-1BB effect. We conclude that the suppression of collagen-induced arthritis was caused by an expansion of new CD11c[sup.+]CD8[sup.+] T cells, and that interferon-[gamma] produced by these cells suppresses antigen-specific CD4[sup.+] T cells through an indoleamine 2,3-dioxygenase-dependent mechanism., Author(s): Su K Seo [1]; Jae H Choi [1]; Young H Kim [1]; Woo J Kang [1]; Hye Y Park [1]; Jae H Suh [2]; Beom K Choi [1]; Dass [...]

Published
2004
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33. Contributors

Author

Abe, Takato, primary, Adams, Harold P., additional, Adeoye, Opeolu, additional, Agarwal, Sachin, additional, Aguilar, Maria I., additional, Al-Khoury, Lama, additional, Arboix, Adrià, additional, Auer, Roland N., additional, Awad, Issam A., additional, Baird, Alison E., additional, Baltan, Selva, additional, Barnett, Henry J.M., additional, Batjer, H. Hunt, additional, Benavente, Oscar R., additional, Bendok, Bernard R., additional, Bershad, Eric M., additional, Binder, Jeffrey R., additional, Boulos, Alan S., additional, Bousser, Marie-Germaine, additional, Bova, Frank J., additional, Brainin, Michael, additional, Brisman, Jonathan L., additional, Brown, Wendy, additional, Brust, John C.M., additional, Canhão, Patrícia, additional, Caplan, Louis R., additional, Castellanos, Mar, additional, Chabriat, Hugues, additional, Chamorro, Angel, additional, Choi, Jae H., additional, Chopp, Michael, additional, Connolly, E. Sander, additional, Coull, Bruce M., additional, Cucchiara, Brett L., additional, Dalkara, Turgay, additional, Dani, Krishna A., additional, Dannenbaum, Mark J., additional, Dashti, Shervin R., additional, Davis, Patricia H., additional, Dawson, Ted M., additional, Dawson, Valina L., additional, Day, Arthur L., additional, De Leo, Michael J., additional, del Zoppo, Gregory J., additional, Diedler, Jennifer, additional, Diener, Hans-Christoph, additional, Di Tullio, Marco R., additional, Dobkin, Bruce H., additional, Drake, Kendra, additional, Du, Rose, additional, Ducros, Anne, additional, Dzialowski, Imanuel, additional, Eddleman, Christopher S., additional, Elhammady, Mohamed Samy, additional, Elkind, Mitchell S.V., additional, Elliott, J. Paul, additional, Ferro, José M., additional, Findlay, J. Max, additional, Friedman, William A., additional, Furie, Karen L., additional, Furlan, Anthony J., additional, Geibprasert, Sasikhan, additional, Gobin, Y. Pierre, additional, Goldberg, Mark P., additional, Goldstein, Larry B., additional, Gonzales, Nicole R., additional, Gounis, Matthew J., additional, Greenberg, Steven M., additional, Greer, David M., additional, Grotta, James C., additional, Hacke, Werner, additional, Hallenbeck, John, additional, Hamann, Gerhard F., additional, Hartmann, Andreas, additional, Hennerici, Michael, additional, Heros, Roberto C., additional, Higashida, Randall, additional, Homma, Shunichi, additional, Hongo, Kazuhiro, additional, Hopkins, L. Nelson, additional, Horiuchi, Tetsuyoshi, additional, Howard, George, additional, Howard, Virginia J., additional, Huddle, Daniel, additional, Iadecola, Costantino, additional, Joutel, Anne, additional, Jüttler, Eric, additional, Kakarla, Udaya K., additional, Kalafut, Mary A., additional, Kannel, William B., additional, Kase, Carlos S., additional, Kasner, Scott E., additional, Kaste, Markku, additional, Khaw, Alexander, additional, Kidwell, Chelsea S., additional, Kim, Helen, additional, Kim, Louis J., additional, Kim, Stanley H., additional, Klijn, Catharina J.M. (Karin), additional, Kobayashi, Shigeaki, additional, Komotar, Ricardo J., additional, Krings, Timo, additional, Kunz, Alexander, additional, Kurth, Tobias, additional, Lamy, Catherine, additional, Lazar, Ronald M., additional, Levy, Elad I., additional, Liebeskind, David S., additional, Lyden, Patrick D., additional, Markham, Joanne, additional, Marshall, Randolph S., additional, Martí-Vilalta, J.L., additional, Mas, Jean-Louis, additional, Mast, Henning, additional, Masuda, Junichi, additional, Mathers, Colin D., additional, Mayberg, Marc R., additional, Meairs, Stephen, additional, Mendelow, Alexander David, additional, Meschia, James F., additional, Miller, Alyson A., additional, Miyawaki, Takahiro, additional, Mocco, J, additional, Mohr, J.P., additional, Morcos, Jacques J., additional, Morgenstern, Lewis B., additional, Moskowitz, Michael A., additional, Nahed, Brian V., additional, Newell, David W., additional, Ofengeim, Dimitry, additional, Ogata, Jun, additional, Ogilvy, Christopher S., additional, Palesch, Yuko Y., additional, Pancioli, Arthur, additional, Park, Min S., additional, Pawlikowska, Ludmila, additional, Pile-Spellman, John, additional, Powers, William J., additional, Puetz, Volker, additional, Ransom, Bruce R., additional, Roine, Risto O., additional, Ruigrok, Ynte M., additional, Rundek, Tatjana, additional, Sacco, Ralph L., additional, Sattenberg, Ronald J., additional, Saver, Jeffrey L., additional, Savitz, Sean I., additional, Seshadri, Sudha, additional, Sharma, Jitendra, additional, Silverboard, Gerald, additional, Singhal, Aneesh B., additional, Sobey, Christopher G., additional, Spetzler, Robert F., additional, Stapf, Christian, additional, Starke, Robert M., additional, Stiefel, Michael F., additional, Strong, Kathleen, additional, Suarez, José I., additional, Sykora, Marek, additional, Tafreshi, Gilda, additional, Brugge, Karel ter, additional, Tilley, Barbara C., additional, Toni, Danilo, additional, Tournier-Lasserve, Elisabeth, additional, Vilela, Marcelo D., additional, von Kummer, Rüdiger, additional, Wakhloo, Ajay K., additional, Warach, Steven, additional, Weksler, Babette B., additional, Willey, Joshua Z., additional, Wintermark, Max, additional, Wolf, Philip A., additional, Woo, Daniel, additional, Yamaguchi, Takenori, additional, Yasaka, Masahiro, additional, Young, William L., additional, Zahuranec, Darin B., additional, Zazulia, Allyson R., additional, Zhang, Zheng Gang, additional, Zukin, R. Suzanne, additional, and Zweifler, Richard M., additional

Published
2011
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41. Evaluation of Novel Sr Precursors for Atomic Layer Deposition of SrO Thin Film

Author

Kim, Ki-Chul, primary, Cho, Kyuho, additional, Lee, Kwanghee, additional, Kim, Younsoo, additional, Choi, Jae H., additional, Lim, Jae-Soon, additional, Kim, Jin Y., additional, Kim, Wan-Don, additional, Kwon, Oh S., additional, Tak, Yong S., additional, Chung, Jeong-Hee, additional, Kim, Young-Sun, additional, Kim, Sung-Tae, additional, and Han, Woosung, additional

Published
2019
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44. Comparison of Synthetic Computed Tomography Generation Methods, Incorporating Male and Female Anatomical Differences, for Magnetic Resonance Imaging-Only Definitive Pelvic Radiotherapy.

Author

O'Connor, Laura M., Choi, Jae H., Dowling, Jason A., Warren-Forward, Helen, Martin, Jarad, and Greer, Peter B.

Subjects
COMPUTED tomography, MAGNETIC resonance imaging, MAGNETIC resonance, RADIOTHERAPY treatment planning, PELVIS
Abstract

Purpose: There are several means of synthetic computed tomography (sCT) generation for magnetic resonance imaging (MRI)-only planning; however, much of the research omits large pelvic treatment regions and female anatomical specific methods. This research aimed to apply four of the most popular methods of sCT creation to facilitate MRI-only radiotherapy treatment planning for male and female anorectal and gynecological neoplasms. sCT methods were validated against conventional computed tomography (CT), with regard to Hounsfield unit (HU) estimation and plan dosimetry. Methods and Materials: Paired MRI and CT scans of 40 patients were used for sCT generation and validation. Bulk density assignment, tissue class density assignment, hybrid atlas, and deep learning sCT generation methods were applied to all 40 patients. Dosimetric accuracy was assessed by dose difference at reference point, dose volume histogram (DVH) parameters, and 3D gamma dose comparison. HU estimation was assessed by mean error and mean absolute error in HU value between each sCT and CT. Results: The median percentage dose difference between the CT and sCT was <1.0% for all sCT methods. The deep learning method resulted in the lowest median percentage dose difference to CT at −0.03% (IQR 0.13, −0.31) and bulk density assignment resulted in the greatest difference at −0.73% (IQR −0.10, −1.01). The mean 3D gamma dose agreement at 3%/2 mm among all sCT methods was 99.8%. The highest agreement at 1%/1 mm was 97.3% for the deep learning method and the lowest was 93.6% for the bulk density method. Deep learning and hybrid atlas techniques gave the lowest difference to CT in mean error and mean absolute error in HU estimation. Conclusions: All methods of sCT generation used in this study resulted in similarly high dosimetric agreement for MRI-only planning of male and female cancer pelvic regions. The choice of the sCT generation technique can be guided by department resources available and image guidance considerations, with minimal impact on dosimetric accuracy. [ABSTRACT FROM AUTHOR]

Published
2022
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49. Designing with plastics: considering part recyclability and the use of recycled materials

Author

D'Anjou, Louis O., Choi, Jae H., Glantschnig, Werner J., and Stefanacci, Emil F.

Subjects
AT&T Corp. -- Environmental policy -- 00300471, Recycling (Waste, etc.) -- Economic aspects, Plastics -- Environmental aspects, Waste minimization -- Economic aspects
Abstract

It is a widely shared view that economic development will not be sustainable unless industry embarks on more innovative and proactive approaches to corporate environmental stewardship. "Green" product realization strategies - such as design for recycling (DFR) - and the increased use of recycled materials in the manufacture of new products are viewed as crucial components of such an approach. AT&T's design and engineering community is active in both fields. DFR is introduced as part of a broader design for environment (DFE) program. In addition, there are ambitious initiatives to find suitable internal uses for plastics recyclate, which AT&T's material reclamation organizations have produced from scrapped telephone housings for many years. These two programs are symbiotic: The greater the number of products designed for recycling, the greater the amount of high-value materials that can be readily recovered from them at the end of their useful lives. In turn, the higher the quality of the recycled materials, the easier to recycle those materials into new products. This paper describes strategies for DFR applicable to plastic parts and discusses two initial applications of post-consumer recycled plastics in new AT&T products.

Published
1995

50. Role of casein kinase 1 in the glucose sensor-mediated signaling pathway in yeast

Author

Choi Jae H, Chakraborty Samujjwal, Pasula Satish, and Kim Jeong-Ho

Subjects
Cytology, QH573-671
Abstract

Abstract Background In yeast, glucose-dependent degradation of the Mth1 protein, a corepressor of the glucose transporter gene (HXT) repressor Rgt1, is a crucial event enabling expression of several HXT. This event occurs through a signaling pathway that involves the Rgt2 and Snf3 glucose sensors and yeast casein kinase 1 and 2 (Yck1/2). In this study, we examined whether the glucose sensors directly couple with Yck1/2 to convert glucose binding into an intracellular signal that leads to the degradation of Mth1. Results High levels of glucose induce degradation of Mth1 through the Rgt2/Snf3 glucose signaling pathway. Fluorescence microscopy analysis indicates that, under glucose-limited conditions, GFP-Mth1 is localized in the nucleus and does not shuttle between the nucleus and cytoplasm. If glucose-induced degradation is prevented due to disruption of the Rgt2/Snf3 pathway, GFP-Mth1 accumulates in the nucleus. When engineered to be localized to the cytoplasm, GFP-Mth1 is degraded regardless of the presence of glucose or the glucose sensors. In addition, removal of Grr1 from the nucleus prevents degradation of GFP-Mth1. These results suggest that glucose-induced, glucose sensor-dependent Mth1 degradation occurs in the nucleus. We also show that, like Yck2, Yck1 is localized to the plasma membrane via C-terminal palmitoylation mediated by the palmitoyl transferase Akr1. However, glucose-dependent degradation of Mth1 is not impaired in the absence of Akr1, suggesting that a direct interaction between the glucose sensors and Yck1/2 is not required for Mth1 degradation. Conclusion Glucose-induced, glucose sensor-regulated degradation of Mth1 occurs in the nucleus and does not require direct interaction of the glucose sensors with Yck1/2.

Published
2010
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