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846 results on '"Choi, J.Y."'

6. ARBM-201 as a Novel Pendrin Inhibitor, Limiting Excess Pro-inflammatory Responses in Lung Cells In Vitro

Author

Kim, E.-J., primary, Lee, H., additional, Park, D., additional, Kim, D., additional, Kim, T., additional, Park, E., additional, Jung, C., additional, Choi, S., additional, Kim, S.-Y., additional, Min, B.-K., additional, Shin, M., additional, Noh, S.H., additional, Song, D., additional, Namkung, W., additional, Han, G., additional, Park, M.S., additional, Choi, J.Y., additional, Lee, M.G., additional, Im, W., additional, and Eun, S.-Y., additional

Published
2024
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13. P144 The Effect of Progesterone Receptor Expression Level to Predict Prognosis of Estrogen Receptor Positive/ HER2 Negative Young Breast Cancer: A Single-Center Prospective Cohort Study

Author

Kwak, Y., primary, Jang, S.Y., additional, Choi, J.Y., additional, Lee, H., additional, Shin, D.S., additional, Park, Y.H., additional, Kim, J.-Y., additional, Ahn, J.-S., additional, Chae, B.-J., additional, Yu, J., additional, Lee, J.E., additional, Kim, S.W., additional, Nam, S.J., additional, and Ryu, J.M., additional

Published
2023
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14. The occurrence of Simpson's paradox if site-level effect was ignored in the TREAT Asia HIV Observational Database

Author

Ly, P.S., Khol, V., Zhang, F.J., Zhao, H.X., Han, N., Lee, M.P., Li, P.C.K., Lam, W., Chan, Y.T., Kumarasamy, N., Saghayam, S., Ezhilarasi, C., Pujari, S., Joshi, K., Gaikwad, S., Chitalikar, A., Merati, T.P., Wirawan, D.N., Yuliana, F., Yunihastuti, E., Imran, D., Widhani, A., Oka, S., Tanuma, J., Nishijima, T., Choi, J.Y., Na, S., Kim, J.M., Sim, B.L.H., Gani, Y.M., David, R., Kamarulzaman, A., Syed Omar, S.F., Ponnampalavanar, S., Azwa, I., Mustafa, M., Nordin, N., Ditangco, R., Uy, E., Bantique, R., Wong, W.W., Ku, W.W., Wu, P.C., Ng, O.T., Lim, P.L., Lee, L.S., Martinez-Vega, R., Phanuphak, P., Ruxrungtham, K., Avihingsanon, A., Chusut, P., Kiertiburanakul, S., Sungkanuparph, S., Chumla, L., Sanmeema, N., Chaiwarith, R., Sirisanthana, T., Kotarathititum, W., Praparattanapan, J., Kantipong, P., Kambua, P., Ratanasuwan, W., Sriondee, R., Nguyen, K.V., Bui, V.H., Nguyen, D.T.H., Nguyen, D.T., Pham, T.T., Cuong, D.D., Ha, H.L., Sohn, A.H., Durier, N., Petersen, B., Cooper, D.A., Law, M.G., Jiamsakul, A., Boettiger, D.C., Jiamsakul, Awachana, Kerr, Stephen J., Chandrasekaran, Ezhilarasi, Huelgas, Aizobelle, Taecharoenkul, Sineenart, Teeraananchai, Sirinya, Wan, Gang, Ly, Penh Sun, Kiertiburanakul, Sasisopin, and Law, Matthew

Published
2016
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19. Comparing the efficacy of different methods of faecal microbiota transplantation via oral capsule, oesophagogastroduodenoscopy, colonoscopy, or gastric tube

Author

Lee, E.H., primary, Lee, S.K., additional, Cheon, J.H., additional, Koh, H., additional, Lee, J.A., additional, Kim, C.H., additional, Kim, J.N., additional, Lee, K.H., additional, Lee, S.J., additional, Kim, J.H., additional, Ahn, J.Y., additional, Jeong, S.J., additional, Ku, N.S., additional, Yong, D.E., additional, Yoon, S.S., additional, Yeom, J.S., additional, and Choi, J.Y., additional

Published
2023
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43. Functional annotation of the 2q35 breast cancer risk locus implicates a structural variant in influencing activity of a long-range enhancer element

Author

Baxter, J.S., Johnson, N., Tomczyk, K., Gillespie, A., Maguire, S., Brough, R., Fachal, L., Michailidou, K., Bolla, M.K., Wang, Q., Dennis, J., Ahearn, T.U., Andrulis, I.L., Anton-Culver, H., Antonenkova, N.N., Arndt, V., Aronson, K.J., Augustinsson, A., Becher, H., Beckmann, M.W., Behrens, S., Benitez, J., Bermisheva, M., Bogdanova, N.V., Bojesen, S.E., Brenner, H., Brucker, S.Y., Cai, Q.Y., Campa, D., Canzian, F., Castelao, J.E., Chan, T.L., Chang-Claude, J., Chanock, S.J., Chenevix-Trench, G., Choi, J.Y., Clarke, C.L., Collaborators, N., Colonna, S., Conroy, D.M., Couch, F.J., Cox, A., Cross, S.S., Czene, K., Daly, M.B., Devilee, P., Dork, T., Dossus, L., Dwek, M., Eccles, D.M., Ekici, A.B., Eliassen, A.H., Engel, C., Fasching, P.A., Figueroa, J., Flyger, H., Gago-Dominguez, M., Gao, C., Garcia-Closas, M., Garcia-Saenz, J.A., Ghoussaini, M., Giles, G.G., Goldberg, M.S., Gonzalez-Neira, A., Guenel, P., Gundert, M., Haeberle, L., Hahnen, E., Haiman, C.A., Hall, P., Hamann, U., Hartman, M., Hatse, S., Hauke, J., Hollestelle, A., Hoppe, R., Hopper, J.L., Hou, M.F., Ito, H., Iwasaki, M., Jager, A., Jakubowska, A., Janni, W., John, E.M., Joseph, V., Jung, A., Kaaks, R., Kang, D., Keeman, R., Khusnutdinova, E., Kim, S.W., Kosma, V.M., Kraft, P., Kristensen, V.N., Kubelka-Sabit, K., Kurian, A.W., Kwong, A., Lacey, J.V., Lambrechts, D., Larson, N.L., Larsson, S.C., Marchand, L. le, Lejbkowicz, F., Li, J.M., Long, J.R., Lophatananon, A., LubiNski, J., Mannermaa, A., Manoochehri, M., Manoukian, S., Margolin, S., Matsuo, K., Mavroudis, D., Mayes, R., Menon, U., Milne, R.L., Taib, N.A.M., Muir, K., Muranen, T.A., Murphy, R.A., Nevanlinna, H., O'Brien, K.M., Offit, K., Olson, J.E., Olsson, H., Park, S.K., Park-Simon, T.W., Patel, A.V., Peterlongo, P., Peto, J., Plaseska-Karanfilska, D., Presneau, N., Pylkas, K., Rack, B., Rennert, G., Romero, A., Ruebner, M., Rudiger, T., Saloustros, E., Sandler, D.P., Sawyer, E.J., Schmidt, M.K., Schmutzler, R.K., Schneeweiss, A., Schoemaker, M.J., Shah, M., Shen, C.Y., Shu, X.O., Simard, J., Southey, M.C., Stone, J., Surowy, H., Swerdlow, A.J., Tamimi, R.M., Tapper, W.J., Taylor, J.A., Teo, S.H., Teras, L.R., Terry, M.B., Toland, A.E., Tomlinson, I., Truong, T., Tseng, C.C., Untch, M., Vachon, C.M., Ouweland, A.M.W. van den, Wang, S.S., Weinberg, C.R., Wendt, C., Winham, S.J., Winqvist, R., Wolk, A., Wu, A.H., Yamaji, T., Zheng, W., Ziogas, A., Pharoah, P.D.P., Dunning, A.M., Easton, D.F., Pettitt, S.J., Lord, C.J., Haider, S., Orr, N., Fletcher, O., kConFab Investigators, ABCTB Investigators, Medical Oncology, Clinical Genetics, HUS Gynecology and Obstetrics, Department of Obstetrics and Gynecology, Biosciences, Dennis, Joe [0000-0003-4591-1214], Pharoah, Paul [0000-0001-8494-732X], Dunning, Alison [0000-0001-6651-7166], Easton, Douglas [0000-0003-2444-3247], and Apollo - University of Cambridge Repository

Subjects
Basic medicine, breast cancer risk, 0302 clinical medicine, Transcription (biology), Risk Factors, WIDE ASSOCIATION, TRANSCRIPTION, Promoter Regions, Genetic, Genetics (clinical), Sequence Deletion, Genetics, Genetics & Heredity, 0303 health sciences, Chromosome Mapping, 3. Good health, 030220 oncology & carcinogenesis, Chromosomes, Human, Pair 2, Pair 2, Female, Medical Genetics, Life Sciences & Biomedicine, Human, Tumor suppressor gene, SUSCEPTIBILITY LOCI, In silico, 3122 Cancers, Locus (genetics), Breast Neoplasms, Biology, Chromosomes, Article, Cell Line, RNAS, Promoter Regions, 03 medical and health sciences, functional annotation, risk locus, CRISPR-Cas Systems, Genetic Association Studies, Genetic Variation, Humans, Insulin-Like Growth Factor Binding Protein 5, Molecular Sequence Annotation, 11Q13, Genetic, SDG 3 - Good Health and Well-being, Enhancer, Transcription factor, 030304 developmental biology, Medicinsk genetik, Reporter gene, Science & Technology, IDENTIFICATION, Clinical medicine, Estrogen receptor alpha
Abstract

A combination of genetic and functional approaches has identified three independent breast cancer risk loci at 2q35. A recent fine-scale mapping analysis to refine these associations resulted in 1 (signal 1), 5 (signal 2), and 42 (signal 3) credible causal variants at these loci. We used publicly available in silico DNase I and ChIP-seq data with in vitro reporter gene and CRISPR assays to annotate signals 2 and 3. We identified putative regulatory elements that enhanced cell-type-specific transcription from the IGFBP5 promoter at both signals (30- to 40-fold increased expression by the putative regulatory element at signal 2, 2- to 3-fold by the putative regulatory element at signal 3). We further identified one of the five credible causal variants at signal 2, a 1.4 kb deletion (esv3594306), as the likely causal variant; the deletion allele of this variant was associated with an average additional increase in IGFBP5 expression of 1.3-fold (MCF-7) and 2.2-fold (T-47D). We propose a model in which the deletion allele of esv3594306 juxtaposes two transcription factor binding regions (annotated by estrogen receptor alpha ChIP-seq peaks) to generate a single extended regulatory element. This regulatory element increases cell-type-specific expression of the tumor suppressor gene IGFBP5 and, thereby, reduces risk of estrogen receptor-positive breast cancer (odds ratio = 0.77, 95% CI 0.74-0.81, p = 3.1 × 10-31). ispartof: AMERICAN JOURNAL OF HUMAN GENETICS vol:108 issue:7 pages:1190-1203 ispartof: location:United States status: published

Published
2021

44. Viral hepatitis cascade of care among adults living with HIV in Asia-Pacific

Author

Rupasinghe, D., Choi, J.Y., Kumarasamy, N., Pujari, S., Ly, P.S., Merati, T.P., Lee, M.P., Nguyen, K.V., Kiertiburanakul, S., Do, C.D., Avihingsanon, A., Ross, J., and Jiamsakul, A.

Subjects
Comorbidity -- Influence, Hepatitis B -- Development and progression -- Care and treatment, Medical care -- Quality management, Hepatitis C -- Development and progression -- Care and treatment, HIV infection -- Complications and side effects -- Care and treatment, Health
Abstract

Background: Data on viral hepatitis (VH) diagnosis, treatment and cure rates among PLHIV from the Asia-Pacific region are limited. With targets set to eliminate VH as a global epidemic by [...]

Published
2021
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