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4. Association between obesity and cancer risk in HIV-infected Asians

Author

Jang, Yoonyoung, primary, Kim, Taehwa, additional, Choi, Yunsu, additional, Ahn, Kyoung Hwan, additional, Kim, Jung Ho, additional, Seong, Hye, additional, Kim, Youn Jeong, additional, Kim, Shin-Woo, additional, Choi, Jun Yong, additional, Kim, Hyo Youl, additional, Song, Joon Young, additional, Choi, Hee Jung, additional, Kim, Sang Il., additional, Sohn, Jang Wook, additional, Chin, BumSik, additional, Choi, Bo-Youl, additional, and Park, Boyoung, additional

Published
2024
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6. Trends for Syndromic Surveillance of Norovirus in Emergency Department Data Based on Chief Complaints.

Author

Kim, Soyeoun, Kim, Sohee, Choi, Bo Youl, and Park, Boyoung

Subjects
EMERGENCY room visits, DIGESTIVE system diseases, EARLY diagnosis, HOSPITAL emergency services, MOVING average process
Abstract

Background This study compared trends in norovirus cases to determine whether chief complaint–based emergency department (ED) visit data could reflect trends of norovirus in Korea. Methods The ED visits from the National Emergency Department Information System database and the weekly reported number of noroviruses from the sentinel surveillance system were collected between August 2017 and December 2020. The correlation between weekly norovirus cases and weekly ED visits considering the chief complaint and discharge diagnosis code was estimated using a 3-week moving average. Results In total, 6 399 774 patients with chief complaints related to digestive system disease visited an ED. A higher correlation between reported norovirus cases and ED visit with chief complaint of vomiting and discharge diagnosis code of gastroenteritis and colitis of unspecified origin or other and unspecified gastroenteritis and colitis of infectious origin was observed (R = 0.88, P <.0001). The correlation was highest for the age group 0–4 years (R = 0.89, P <.0001). However, no correlation was observed between the reported norovirus cases and the number of ED visits with norovirus identified as a discharge diagnosis code. Conclusions ED visit data considering a combination of chief complaints and discharged diagnosis code would be useful for early detection of infectious disease trends. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference.

Author

Wen, Wanqing, Kato, Norihiro, Hwang, Joo-Yeon, Guo, Xingyi, Tabara, Yasuharu, Li, Huaixing, Dorajoo, Rajkumar, Yang, Xiaobo, Tsai, Fuu-Jen, Li, Shengxu, Wu, Ying, Wu, Tangchun, Kim, Soriul, Guo, Xiuqing, Liang, Jun, Shungin, Dmitry, Adair, Linda S, Akiyama, Koichi, Allison, Matthew, Cai, Qiuyin, Chang, Li-Ching, Chen, Chien-Hsiun, Chen, Yuan-Tsong, Cho, Yoon Shin, Choi, Bo Youl, Gao, Yutang, Go, Min Jin, Gu, Dongfeng, Han, Bok-Ghee, He, Meian, Hixson, James E, Hu, Yanling, Huang, Tao, Isono, Masato, Jung, Keum Ji, Kang, Daehee, Kim, Young Jin, Kita, Yoshikuni, Lee, Juyoung, Lee, Nanette R, Lee, Jeannette, Wang, Yiqin, Liu, Jian-Jun, Long, Jirong, Moon, Sanghoon, Nakamura, Yasuyuki, Nakatochi, Masahiro, Ohnaka, Keizo, Rao, Dabeeru, Shi, Jiajun, Sull, Jae Woong, Tan, Aihua, Ueshima, Hirotsugu, Wu, Chen, Xiang, Yong-Bing, Yamamoto, Ken, Yao, Jie, Ye, Xingwang, Yokota, Mitsuhiro, Zhang, Xiaomin, Zheng, Yan, Qi, Lu, Rotter, Jerome I, Jee, Sun Ha, Lin, Dongxin, Mohlke, Karen L, He, Jiang, Mo, Zengnan, Wu, Jer-Yuarn, Tai, E Shyong, Lin, Xu, Miki, Tetsuro, Kim, Bong-Jo, Takeuchi, Fumihiko, Zheng, Wei, and Shu, Xiao-Ou

Subjects
Humans, Obesity, Genetic Predisposition to Disease, Waist-Hip Ratio, Sex Factors, Quantitative Trait, Heritable, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Asian Continental Ancestry Group, Asia, Female, Male, Waist Circumference, Genome-Wide Association Study, Quantitative Trait, Heritable, Polymorphism, Single Nucleotide, Clinical Research, Genetics, 2.1 Biological and endogenous factors, Cardiovascular, Biochemistry and Cell Biology, Other Physical Sciences
Abstract

Sixty genetic loci associated with abdominal obesity, measured by waist circumference (WC) and waist-hip ratio (WHR), have been previously identified, primarily from studies conducted in European-ancestry populations. We conducted a meta-analysis of associations of abdominal obesity with approximately 2.5 million single nucleotide polymorphisms (SNPs) among 53,052 (for WC) and 48,312 (for WHR) individuals of Asian descent, and replicated 33 selected SNPs among 3,762 to 17,110 additional individuals. We identified four novel loci near the EFEMP1, ADAMTSL3 , CNPY2, and GNAS genes that were associated with WC after adjustment for body mass index (BMI); two loci near the NID2 and HLA-DRB5 genes associated with WHR after adjustment for BMI, and three loci near the CEP120, TSC22D2, and SLC22A2 genes associated with WC without adjustment for BMI. Functional enrichment analyses revealed enrichment of corticotropin-releasing hormone signaling, GNRH signaling, and/or CDK5 signaling pathways for those newly-identified loci. Our study provides additional insight on genetic contribution to abdominal obesity.

Published
2016

12. Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index

Author

Wen, Wanqing, Zheng, Wei, Okada, Yukinori, Takeuchi, Fumihiko, Tabara, Yasuharu, Hwang, Joo-Yeon, Dorajoo, Rajkumar, Li, Huaixing, Tsai, Fuu-Jen, Yang, Xiaobo, He, Jiang, Wu, Ying, He, Meian, Zhang, Yi, Liang, Jun, Guo, Xiuqing, Sheu, Wayne Huey-Herng, Delahanty, Ryan, Guo, Xingyi, Kubo, Michiaki, Yamamoto, Ken, Ohkubo, Takayoshi, Go, Min Jin, Liu, Jian Jun, Gan, Wei, Chen, Ching-Chu, Gao, Yong, Li, Shengxu, Lee, Nanette R, Wu, Chen, Zhou, Xueya, Song, Huaidong, Yao, Jie, Lee, I-Te, Long, Jirong, Tsunoda, Tatsuhiko, Akiyama, Koichi, Takashima, Naoyuki, Cho, Yoon Shin, Ong, Rick TH, Lu, Ling, Chen, Chien-Hsiun, Tan, Aihua, Rice, Treva K, Adair, Linda S, Gui, Lixuan, Allison, Matthew, Lee, Wen-Jane, Cai, Qiuyin, Isomura, Minoru, Umemura, Satoshi, Kim, Young Jin, Seielstad, Mark, Hixson, James, Xiang, Yong-Bing, Isono, Masato, Kim, Bong-Jo, Sim, Xueling, Lu, Wei, Nabika, Toru, Lee, Juyoung, Lim, Wei-Yen, Gao, Yu-Tang, Takayanagi, Ryoichi, Kang, Dae-Hee, Wong, Tien Yin, Hsiung, Chao Agnes, Wu, I-Chien, Juang, Jyh-Ming Jimmy, Shi, Jiajun, Choi, Bo Youl, Aung, Tin, Hu, Frank, Kim, Mi Kyung, Lim, Wei Yen, Wang, Tzung-Dao, Shin, Min-Ho, Lee, Jeannette, Ji, Bu-Tian, Lee, Young-Hoon, Young, Terri L, Shin, Dong Hoon, Chun, Byung-Yeol, Cho, Myeong-Chan, Han, Bok-Ghee, Hwu, Chii-Min, Assimes, Themistocles L, Absher, Devin, Yan, Xiaofei, Kim, Eric, Kuo, Jane Z, Kwon, Soonil, Taylor, Kent D, Chen, Yii-Der I, Rotter, Jerome I, Qi, Lu, Zhu, Dingliang, Wu, Tangchun, Mohlke, Karen L, and Gu, Dongfeng

Subjects
Biological Sciences, Genetics, Obesity, Nutrition, Human Genome, Women's Health, 5'-Nucleotidase, Aldehyde Dehydrogenase, Aldehyde Dehydrogenase, Mitochondrial, Asian People, Blood Proteins, Body Mass Index, Cardiac Myosins, Asia, Eastern, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Glycoproteins, Humans, KCNQ1 Potassium Channel, Male, Myosin Light Chains, Polymorphism, Single Nucleotide, Proteinase Inhibitory Proteins, Secretory, Medical and Health Sciences, Genetics & Heredity
Abstract

Recent genetic association studies have identified 55 genetic loci associated with obesity or body mass index (BMI). The vast majority, 51 loci, however, were identified in European-ancestry populations. We conducted a meta-analysis of associations between BMI and ∼2.5 million genotyped or imputed single nucleotide polymorphisms among 86 757 individuals of Asian ancestry, followed by in silico and de novo replication among 7488-47 352 additional Asian-ancestry individuals. We identified four novel BMI-associated loci near the KCNQ1 (rs2237892, P = 9.29 × 10(-13)), ALDH2/MYL2 (rs671, P = 3.40 × 10(-11); rs12229654, P = 4.56 × 10(-9)), ITIH4 (rs2535633, P = 1.77 × 10(-10)) and NT5C2 (rs11191580, P = 3.83 × 10(-8)) genes. The association of BMI with rs2237892, rs671 and rs12229654 was significantly stronger among men than among women. Of the 51 BMI-associated loci initially identified in European-ancestry populations, we confirmed eight loci at the genome-wide significance level (P < 5.0 × 10(-8)) and an additional 14 at P < 1.0 × 10(-3) with the same direction of effect as reported previously. Findings from this analysis expand our knowledge of the genetic basis of obesity.

Published
2014

18. Association Between Relative Quadriceps Strength and Type 2 Diabetes Mellitus in Older Adults: The Yangpyeong Cohort of the Korean Genome and Epidemiology Study.

Author

Song, Bong Kil, Kim, Geon Hui, Kim, Jung Woon, Lefferts, Elizabeth C., Brellenthin, Angelique G., Lee, Duck-Chul, Kim, Yu-Mi, Kim, Mi Kyung, Choi, Bo Youl, and Kim, Yeon Soo

Subjects
QUADRICEPS muscle, MUSCLE strength, TYPE 2 diabetes, DISEASE prevalence, HEALTH of older people, BODY mass index, EPIDEMIOLOGICAL research
Abstract

Background: To examine the independent and combined association between relative quadriceps strength and the prevalence of type 2 diabetes mellitus (T2DM) in older adults. Methods: Among 1441 Korean older adults aged ≥65 years (71 [4.7] y) recruited between 2007 and 2016, 1055 older adults with no history of myocardial infarction, stroke, or cancer were included in the analysis. Cases of T2DM were identified by self-reported physician diagnosis, use antihyperglycemic medication or insulin, or fasting blood glucose ≥126 mg/dL. Logistic regression was used to calculate the odds ratios and 95% confidence intervals of T2DM by quartiles of relative quadriceps strength. Results: There were 162 T2DM cases (15%). Compared with the lowest quartile (weakest), the odds ratios (95% confidence intervals) of T2DM were 0.56 (0.34–0.90), 0.60 (0.37–0.96), and 0.47 (0.28–0.80) in the second, third, and fourth quartiles, respectively, after adjusting for possible confounders, including body mass index. In the joint analysis, compared with the "weak and overweight/obese" group, the odds (odds ratios [95% confidence intervals]) of T2DM was only lower in the "strong and normal weight" group (0.36 [0.22–0.60]) after adjusting for possible confounders. Conclusions: Greater relative quadriceps strength is associated with reduced odds of T2DM in older adults after adjusting for potential confounders including body mass index. [ABSTRACT FROM AUTHOR]

Published
2021
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20. GAREM1 regulates the PR interval on electrocardiograms

Author

Kim, Hye Ok, Lim, Ji Eun, Kim, Myung Jun, Kang, Ji-One, Kim, Sung-Moon, Nam, Jeong Min, Tak, Jihoon, Konishi, Hiroaki, Nishino, Tasuku, Koh, In Song, Jin, Young-Ho, Baik, Hyung Hwan, Kim, Jin-Bae, Kim, Mi Kyung, Choi, Bo Youl, Lee, Sang-Hak, Jang, Yangsoo, Shin, Jinho, and Oh, Bermseok

Published
2018
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23. Understanding School Health Environment through Interviews with Key Stakeholders in Lao PDR, Mongolia, Nepal and Sri Lanka

Author

Park, Sohyun, Lee, Eun Young, Gittelsohn, Joel, Nkala, Denis, and Choi, Bo Youl

Abstract

Studies on health promoting schools (HPS) in low- and middle-income countries (LMICs) are scarce. To contribute to the development of HPS in these countries, we conducted formative research to understand the school environment in Lao PDR, Mongolia, Nepal, and Sri Lanka. Forty-three teachers, 10 government workers and 5 parents participated in three one-on-one interviews and 14 natural group interviews. Six themes emerged that centered on insufficient resources as reasons for suboptimal health conditions. At the individual level, participants mentioned the deficiency of personal resources to cope with cold weather and poor diet. At the school level, the lack of physical resources such as water purifiers and latrines was discussed. Interviewees also pointed out the schools' overdependence on external resources and therefore the lack of sustainability. Last, the shortage of health services at the school and community level was commonly mentioned. Based on these results, we believe that the basic concept of HPSs should also be applied when working with schools in LMICs. In conclusion, there was a lack of perception of the importance of policy and capacity development programs, which are important in developing HPSs. Therefore, future school health programs should stress improving these elements.

Published
2015
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24. Assessment of Disease Burden and Immunization Rates for Vaccine-Preventable Diseases in People Living with HIV: The Korea HIV/AIDS Cohort Study

Author

Seong, Hye, primary, Choi, Yunsu, additional, Ahn, Kyoung Hwan, additional, Choi, Jun Yong, additional, Kim, Shin-Woo, additional, Kim, Sang Il, additional, Kee, Mee-Kyung, additional, Choi, Bo Youl, additional, Park, Boyoung, additional, Hyun, Hak Jun, additional, Yoon, Jin Gu, additional, Noh, Ji Yun, additional, Cheong, Hee Jin, additional, Kim, Woo Joo, additional, and Song, Joon Young, additional

Published
2023
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35. Mortality and Causes of Death among Individuals Diagnosed with Human Immunodeficiency Virus in Korea, 2004–2018: An Analysis of a Nationwide Population-Based Claims Database

Author

Park, Boyoung, primary, Choi, Yunsu, additional, Kim, Jung Ho, additional, Seong, Hye, additional, Kim, Youn Jeong, additional, Lee, Myungsun, additional, Seong, Jaehyun, additional, Kim, Shin-Woo, additional, Song, Joon Young, additional, Choi, Hee-Jung, additional, Park, Dae Won, additional, Kim, Hyo Youl, additional, Choi, Jun Yong, additional, Kim, Sang Il, additional, and Choi, Bo-Youl, additional

Published
2022
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