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149 results on '"Chobufo, Muchi Ditah"'

2. Gestational diabetes mellitus in Cameroon: prevalence, risk factors and screening strategies

Author

Eugene Sobngwi, Joelle Sobngwi-Tambekou, Jean Claude Katte, Justin B. Echouffo-Tcheugui, Eric V. Balti, Andre-Pascal Kengne, Leopold Fezeu, Chobufo Muchi Ditah, Alain-Patrick Tchatchoua, Mesmin Dehayem, Nigel C. Unwin, Judith Rankin, Jean Claude Mbanya, and Ruth Bell

Subjects
gestational diabetes mellitus, screening, prevalence, risk factors, Cameroon, sub-Saharan Africa, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

BackgroundThe burden of gestational diabetes (GDM) and the optimal screening strategies in African populations are yet to be determined. We assessed the prevalence of GDM and the performance of various screening tests in a Cameroonian population.MethodsWe carried out a cross-sectional study involving the screening of 983 women at 24-28 weeks of pregnancy for GDM using serial tests, including fasting plasma (FPG), random blood glucose (RBG), a 1-hour 50g glucose challenge test (GCT), and standard 2-hour oral glucose tolerance test (OGTT). GDM was defined using the World Health Organization (WHO 1999), International Association of Diabetes and Pregnancy Special Group (IADPSG 2010), and National Institute for Health Care Excellence (NICE 2015) criteria. GDM correlates were assessed using logistic regressions, and c-statistics were used to assess the performance of screening strategies.FindingsGDM prevalence was 5·9%, 17·7%, and 11·0% using WHO, IADPSG, and NICE criteria, respectively. Previous stillbirth [odds ratio: 3·14, 95%CI: 1·27-7·76)] was the main correlate of GDM. The optimal cut-points to diagnose WHO-defined GDM were 5·9 mmol/L for RPG (c-statistic 0·62) and 7·1 mmol/L for 1-hour 50g GCT (c-statistic 0·76). The same cut-off value for RPG was applicable for IADPSG-diagnosed GDM while the threshold was 6·5 mmol/L (c-statistic 0·61) for NICE-diagnosed GDM. The optimal cut-off of 1-hour 50g GCT was similar for IADPSG and NICE-diagnosed GDM. WHO-defined GDM was always confirmed by another diagnosis strategy while IADPSG and GCT independently identified at least 66·9 and 41·0% of the cases.InterpretationGDM is common among Cameroonian women. Effective detection of GDM in under-resourced settings may require simpler algorithms including the initial use of FPG, which could substantially increase screening yield.

Published
2024
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8. Sex and Racial Disparities in Proportionate Mortality of Premature Myocardial Infarction in the United States: 1999 to 2020

Author

Gonuguntla, Karthik, primary, Badu, Irisha, additional, Duhan, Sanchit, additional, Sandhyavenu, Harigopal, additional, Chobufo, Muchi Ditah, additional, Taha, Amro, additional, Thyagaturu, Harshith, additional, Sattar, Yasar, additional, Keisham, Bijeta, additional, Ali, Shafaqat, additional, Khan, Muhammad Zia, additional, Latchana, Sharaad, additional, Naeem, Minahil, additional, Shaik, Ayesha, additional, Balla, Sudarshan, additional, and Gulati, Martha, additional

Published
2024
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10. Temporal Trends of Infant Mortality Secondary to Congenital Heart Disease: National CDC Cohort Analysis (1999–2020).

Author

Chobufo, Muchi Ditah, Ali, Shafaqat, Taha, Amro, Duhan, Sanchit, Patel, Neel, Gonuguntla, Karthik, Ludhwani, Dipesh, Thyagaturu, Harshith, Keisham, Bijeta, Shaik, Ayesha, Alharbi, Anas, Sattar, Yasar, Mamas, Mamas A., Kohli, Utkarsh, and Balla, Sudarshan

Abstract

Background: Infant mortality continues to be a significant problem for patients with congenital heart disease (CHD). Limited data exist on the recent trends of mortality in infants with CHD. Methods: The CDC WONDER (Centers for Disease Control and Prevention Wide‐Ranging Online Data for Epidemiologic Research) was queried to identify deaths occurring within the United States with CHD listed as one of the causes of death between 1999 and 2020. Subsequently, trends were calculated using the Joinpoint regression program (version 4.9.1.0; National Cancer Institute). Results: A total of 47,015 deaths occurred in infants due to CHD at the national level from the year 1999 to 2020. The overall proportional infant mortality (compared to all deaths) declined (47.3% to 37.1%, average annual percent change [AAPC]: −1.1 [95% CI −1.6 to −0.6, p < 0.001]). There was a significant decline in proportional mortality in both Black (45.3% to 34.3%, AAPC: −0.5 [−0.8 to −0.2, p = 0.002]) and White patients (55.6% to 48.6%, AAPC: −1.2 [−1.7 to −0.7, p = 0.001]), with a steeper decline among White than Black patients. A statistically significant decline in the proportional infant mortality in both non‐Hispanic (43.3% to 33.0%, AAPC: −1.3% [95% CI −1.9 to −0.7, p < 0.001]) and Hispanic (67.6% to 57.7%, AAPC: −0.7 [95% CI −0.9 to −0.4, p < 0.001]) patients was observed, with a steeper decline among non‐Hispanic infant population. The proportional infant mortality decreased in males (47.5% to 53.1%, AAPC: −1.4% [−1.9 to −0.9, p < 0.001]) and females (47.1% to 39.6%, AAPC: −0.9 [−1.9 to 0.0, p = 0.05]). A steady decline in for both females and males was noted. Conclusion: Our study showed a significant decrease in CHD‐related mortality rate in infants and age‐adjusted mortality rate (AAMR) between 1999 and 2020. However, sex‐based, racial/ethnic disparities were noted, with female, Black, and Hispanic patients showing a lesser decline than male, White, and non‐Hispanic patients. [ABSTRACT FROM AUTHOR]

Published
2024
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30. IMPACT OF DIFFERENT LVOT GEOMETRIES IN CALCULATING AORTIC VALVE AREA

Author

Gonuguntla, Karthik, primary, Uqaily, Muhammad, additional, Ludhwani, Dipesh, additional, Sattar, Yasar, additional, Sankaramangalam, Kesavan, additional, Bansal, Raahat, additional, Chobufo, Muchi Ditah, additional, Thyagaturu, Harshith, additional, Hamirani, Yasmin S., additional, Daggubati, Ramesh Babu, additional, and Zeb, Irfan, additional

Published
2023
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34. Trends and Outcomes of Type 2 Myocardial Infarction During the COVID-19 Pandemic in the United States

Author

Thyagaturu, Harshith, primary, Roma, Nicholas, additional, Angirekula, Aakash, additional, Thangjui, Sittinun, additional, Bolton, Alex, additional, Gonuguntla, Karthik, additional, Sattar, Yasar, additional, Chobufo, Muchi Ditah, additional, Challa, Abhiram, additional, Patel, Neel, additional, Bondi, Gayatri, additional, and Raina, Sameer, additional

Published
2023
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40. HIGHER BODY MASS INDEX IN EARLY ADULTHOOD AND SUBSEQUENT RISK OF HEART FAILURE

Author

Rahman, Ebad Ur, primary, Farah, Fatima, additional, Chobufo, Muchi Ditah, additional, Ezeh, Ebubechukwu, additional, Mansoor, Kanaan, additional, Olubowale, Olusola, additional, Tashani, Mohamed, additional, Fonarow, Gregg C., additional, Studeny, Mark A., additional, Thompson, Ellen A., additional, and Rios, Carlos Alberto Rueda, additional

Published
2022
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42. Ethical implications of HIV self-testing: the game is far from being over

Author

Luchuo Engelbert Bain, Chobufo Muchi Ditah, Paschal Kum Awah, and Nkoke Clovis Ekukwe

Subjects
ethics, self-testing, hiv, aids, Medicine
Abstract

The use of combined Anti-Retroviral Therapy (cART) has been revolutionary in the history of the fight against HIV-AIDS, with remarkable reductions in HIV associated morbidity and mortality. Knowing one's HIV status early, not only increases chances of early initiation of effective, affordable and available treatment, but has lately been associated with an important potential to reduce disease transmission. A public health priority lately has been to lay emphasis on early and wide spread HIV screening. With many countries having already in the market over the counter self-testing kits, the ethical question whether self-testing in HIV with such kits is acceptable remains unanswered. Many Western authors have been firm on the fact that this approach enhances patient autonomy and is ethically grounded. We argue that the notion of patient autonomy as proposed by most ethicists assumes perfect understanding of information around HIV, neglects HIV associated stigma as well as proper identification of risky situations that warrant an HIV test. Putting traditional clinic based HIV screening practice into the shadows might be too early, especially for developing countries and potentially very dangerous. Encouraging self-testing as a measure to accompany clinic based testing in our opinion stands as main precondition for public health to invest in HIV self-testing. We agree with most authors that hard to reach risky groups like men and Men Who Have Sex with Men (MSM) are easily reached with the self-testing approach. However, linking self-testers to the medical services they need remains a key challenge, and an understudied indispensable obstacle in making this approach to obtain its desired goals.

Published
2016
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50. Outcomes of

Author

Vijay, Gayam, Amrendra Kumar, Mandal, Chobufo Muchi, Ditah, Jasdeep, Sidhu, Venu Madhav, Konala, Sreedhar, Adapa, Srikanth, Naramala, and Pavani, Garlapati

Subjects
Male, Length of Stay, Middle Aged, Patient Acceptance of Health Care, Vitamin D Deficiency, United States, Hospitalization, Treatment Outcome, Clostridium Infections, Humans, Female, Hospital Mortality, Propensity Score, Retrospective Studies
Abstract

We aimed to determine in-hospital outcomes, length of hospital stay, and resource utilization in a contemporary cohort ofThe National Inpatient Sample database for 2016 and 2017 was used for data analysis usingWe identified 202,234 patients with CDI, 4515 of whom were patients with VDD and 197,719 of whom were without VDD. After propensity matching, there was no difference in the in-hospital mortality between the two groups (odds ratio [OR] 1.5, 95% confidence interval [CI] 0.58-4.3;In this large cohort in a propensity-matched analysis, VDD does not increase the in-hospital mortality in CDI. VDD increases the odds of complications with a higher LOS and resource utilization. These findings may be clinically relevant to guide clinicians to routinely monitor vitamin D status and supplement in patients at risk of CDI.

Published
2020

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