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427 results on '"Cho, Kyu-Sup"'

5. Immunomodulatory Effect of Adipose Stem Cell-Derived Extra-Cellular Vesicles on Cytokine Expression and Regulatory T Cells in Patients with Asthma.

Author

Jung, Jae Hoon, Kang, Shin Ae, Park, Ji-Hwan, Kim, Sung-Dong, Yu, Hak Sun, Mun, Sue Jean, and Cho, Kyu-Sup

Subjects
MONONUCLEAR leukocytes, REGULATORY T cells, MESENCHYMAL stem cells, CELL analysis, FAT cells, T cells
Abstract

Although mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) are as effective as MSCs in the suppression of allergic airway inflammation, few studies have evaluated the immunomodulatory capacity of MSC-derived EVs in patients with asthma. Thus, we assessed the effects of adipose stem cell (ASC)-derived EVs on cytokine expression and regulatory T cells (Tregs) in peripheral blood mononuclear cells (PBMCs) of asthmatic patients. PBMCs (1 × 106 cells/mL) were isolated from asthmatic patient and healthy controls and co-cultured with 1 μg/mL of ASC-derived EVs. Th (T helper) 1-, Th2-, and Treg-related cytokine expression, fluorescence-activated cell sorting analysis of CD4+CD25+FOXP3+ T cells, and co-stimulatory molecules were analyzed before and after ASC-derived EV treatment. The expression levels of IL-4 and costimulatory molecules such as CD83 and CD86 were significantly higher in PBMCs of asthmatic patients than in control PBMCs. However, ASC-derived EV treatment significantly decreased the levels of interleukin (IL)-4 and co-stimulatory molecules such as CD83 and CD86 in the phytohemagglutinin (PHA)-stimulated PBMC of asthmatic patients. Furthermore, ASC-derived EVs remarkably increased the transforming growth factor-β (TGF-β) levels and expression of Tregs in the PBMC of asthmatic patients. ASC-derived EVs induce Treg expansion and have immunomodulatory effects by downregulating IL-4 and upregulating TGF-β in PBMCs of asthmatic patients. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Resection of Huge Nasal Septal Chondroma Via Endoscopic Septoplasty Approach Through Modified Killian Incision.

Author

Kwak, Hyun-Ho, Park, Ji-Hwan, Kim, Sung-Dong, and Cho, Kyu-Sup

Subjects
NASAL cavity, PARANASAL sinuses, COMPUTED tomography, ENDOSCOPIC surgery, NASAL tumors, MAGNETIC resonance imaging, NASAL mucosa, ENCHONDROMA, NASAL septum, ENDOSCOPY, SYMPTOMS
Abstract

Chondromas are benign cartilaginous tumors that frequently occur in the long bones, pelvis, sternum, ribs, and scapula. They seldom develop in the head and neck region, and there have been rare reports of them arising in the nasal septum. Although the mainstay of management is surgery, surgical treatment strategies vary depending on the size, location, and extent of the disease. Herein, we describe a case of huge chondroma originated from the anterior nasal septum, which was completely removed by endoscopic septoplasty approach thorough modified Killian incision. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Chronic Eustachian Tube Dilatory Dysfunction as a Manifestation of Meningioma.

Author

Choi, Sung-Won, Hwangbo, Lee, Cho, Kyu-Sup, and Kong, Soo-Keun

Subjects
EUSTACHIAN tube, COMPUTED tomography, RADIOSURGERY, TREATMENT effectiveness, AUDIOMETRY, MAGNETIC resonance imaging, MENINGIOMA, HEARING disorders, SYMPTOMS
Abstract

The article describes the case of chronic Eustachian tube dilatory dysfunction (ETD) as a manifestation of meningioma and highlights the importance of first-line imaging in the diagnosis. Topics discussed include findings on computed tomography (CT) scans, clinical characteristics of chronic ETD, and rarity of diagnoses of meningiomas extending to the ET.

Published
2024
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41. Image-guided navigation surgery for bilateral choanal atresia with a Tessier number 3 facial cleft in an adult

Author

Sung, Ji Yoon, Cho, Kyu-Sup, Bae, Yong Chan, and Bae, Seong Hwan

Subjects
Imaging, three-dimensional, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, Surgery, plastic, Craniofacial abnormality, medicine.medical_treatment, Case Report, Choanal atresia, Nose, Otolaryngology, 03 medical and health sciences, 0302 clinical medicine, Craniofacial abnormalities, otorhinolaryngologic diseases, medicine, Computer-assisted, Craniofacial, 030223 otorhinolaryngology, business.industry, Facial cleft, 030206 dentistry, medicine.disease, Nasal obstruction, Surgery, Bilateral choanal atresia, Septoplasty, medicine.anatomical_structure, Otorhinolaryngology, Face, Atresia, business
Abstract

The coexistence of craniofacial cleft and bilateral choanal atresia has only been reported in three cases in the literature, and only one of those cases involved a Tessier number 3 facial cleft. It is also rare for bilateral choanal atresia to be found in adulthood, with 10 previous cases reported in the literature. This report presents the case of a 19-year-old woman with a Tessier number 3 facial cleft who was diagnosed with bilateral choanal atresia in adulthood. At first, the diagnosis of bilateral choanal atresia was missed and septoplasty was performed. After septoplasty, the patient’s symptoms did not improve, and an endoscopic examination revealed previously unnoticed bilateral choanal atresia. Computed tomography showed left membranous atresia and right bony atresia. The patient underwent an operation for opening and widening of the left choana with an image-guided navigation system (IGNS), which enabled accurate localization of the lesion while ensuring patient safety. Postoperatively, the patient became able to engage in nasal breathing and reported that it was easier for her to breathe, and there were no signs of restenosis at a 26-month follow-up. The patient was successfully treated with an IGNS.

Published
2020
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