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438 results on '"Cho, Hee‐Jin"'

3. Pharmacogenomic profiling reveals molecular features of chemotherapy resistance in IDH wild-type primary glioblastoma

Author

Nam, Yoonhee, Koo, Harim, Yang, Yingxi, Shin, Sang, Zhu, Zhihan, Kim, Donggeon, Cho, Hee Jin, Mu, Quanhua, Choi, Seung Won, Sa, Jason K., Seo, Yun Jee, Kim, Yejin, Lee, Kyoungmin, Oh, Jeong-Woo, Kwon, Yong-Jun, Park, Woong-Yang, Kong, Doo-Sik, Seol, Ho Jun, Lee, Jung-Il, Park, Chul-Kee, Lee, Hye Won, Yoon, Yeup, and Wang, Jiguang

Published
2023
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5. Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling

Author

Jeon, Hye-Min, Kim, Jeong-Yub, Cho, Hee Jin, Lee, Won Jun, Nguyen, Dayna, Kim, Sung Soo, Oh, Young Taek, Kim, Hee-Jin, Jung, Chan-Woong, Pinero, Gonzalo, Joshi, Tanvi, Hambardzumyan, Dolores, Sakaguchi, Takuya, Hubert, Christopher G., McIntyre, Thomas M., Fine, Howard A., Gladson, Candece L., Wang, Bingcheng, Purow, Benjamin W., Park, Jong Bae, Park, Myung Jin, Nam, Do-Hyun, and Lee, Jeongwu

Published
2023
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7. Extrahepatic Malignancies and Antiviral Drugs for Chronic Hepatitis B: A Nationwide Cohort Study

Author

Hur, Moon Haeng, primary, Lee, Dong Hyeon, additional, Lee, Jeong-Hoon, additional, Kim, Mi-Sook, additional, Park, Jeayeon, additional, Shin, Hyunjae, additional, Chung, Sung Won, additional, Cho, Hee Jin, additional, Park, Min Kyung, additional, Jang, Heejoon, additional, Lee, Yun Bin, additional, Yu, Su Jong, additional, Lee, Sang Hyub, additional, Jung, Yong Jin, additional, Kim, Yoon Jun, additional, and Yoon, Jung-Hwan, additional

Published
2024
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9. Hepatocellular carcinoma patients with high circulating cytotoxic T cells and intra-tumoral immune signature benefit from pembrolizumab: results from a single-arm phase 2 trial

Author

Hong, Jung Yong, Cho, Hee Jin, Sa, Jason K., Liu, Xiaoqiao, Ha, Sang Yun, Lee, Taehyang, Kim, Hajung, Kang, Wonseok, Sinn, Dong Hyun, Gwak, Geum-Youn, Choi, Moon Seok, Lee, Joon Hyeok, Koh, Kwang Cheol, Paik, Seung Woon, Park, Hee Chul, Kang, Tae Wook, Rhim, Hyunchul, Lee, Su Jin, Cristescu, Razvan, Lee, Jeeyun, Paik, Yong Han, and Lim, Ho Yeong

Published
2022
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10. The Rationalization of Korean Universities

Author

Kim, Bo Kyoung, Hwang, Hokyu, Cho, Hee Jin, and Jang, Yong Suk

Abstract

The expansion of the higher education system and the rationalization of universities in South Korea, while broadly following the global patterns, reflect the characteristics of the national political system. We show the rapid growth of universities and document core organizational changes among universities: the elaboration of faculty performance evaluation rules, the expansion and differentiation of central administrations, and the emergence of engagement in vision statements. These changes, constructing universities as organizational actors, parallel the changes in higher education systems elsewhere. However, the uniqueness of the Korean experience lies with the role of the state as a catalyst guiding the overall direction and the structure and strategy of universities. We discuss the implications of our research for the rationalization of universities in a highly centralized system.

Published
2019
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14. Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment

Author

Wang, Qianghu, Hu, Baoli, Hu, Xin, Kim, Hoon, Squatrito, Massimo, Scarpace, Lisa, deCarvalho, Ana C, Lyu, Sali, Li, Pengping, Li, Yan, Barthel, Floris, Cho, Hee Jin, Lin, Yu-Hsi, Satani, Nikunj, Martinez-Ledesma, Emmanuel, Zheng, Siyuan, Chang, Edward, Sauvé, Charles-Etienne Gabriel, Olar, Adriana, Lan, Zheng D, Finocchiaro, Gaetano, Phillips, Joanna J, Berger, Mitchel S, Gabrusiewicz, Konrad R, Wang, Guocan, Eskilsson, Eskil, Hu, Jian, Mikkelsen, Tom, DePinho, Ronald A, Muller, Florian, Heimberger, Amy B, Sulman, Erik P, Nam, Do-Hyun, and Verhaak, Roel GW

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Genetics, Brain Cancer, Neurosciences, Brain Disorders, Cancer, Rare Diseases, 2.1 Biological and endogenous factors, Aetiology, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Glioblastoma, Humans, Phenotype, Recurrence, Survival Analysis, T-Lymphocytes, Tumor Microenvironment, disease recurrence, glioblastoma, immune cells, macrophages/microglia, mesenchymal subtype, proneural to mesenchymal transition, tumor evolution, tumor microenvironment, Oncology & Carcinogenesis, Biochemistry and cell biology, Oncology and carcinogenesis
Abstract

We leveraged IDH wild-type glioblastomas, derivative neurospheres, and single-cell gene expression profiles to define three tumor-intrinsic transcriptional subtypes designated as proneural, mesenchymal, and classical. Transcriptomic subtype multiplicity correlated with increased intratumoral heterogeneity and presence of tumor microenvironment. In silico cell sorting identified macrophages/microglia, CD4+ T lymphocytes, and neutrophils in the glioma microenvironment. NF1 deficiency resulted in increased tumor-associated macrophages/microglia infiltration. Longitudinal transcriptome analysis showed that expression subtype is retained in 55% of cases. Gene signature-based tumor microenvironment inference revealed a decrease in invading monocytes and a subtype-dependent increase in macrophages/microglia cells upon disease recurrence. Hypermutation at diagnosis or at recurrence associated with CD8+ T cell enrichment. Frequency of M2 macrophages detection associated with short-term relapse after radiation therapy.

Published
2017

16. The semaphorin 3A/neuropilin-1 pathway promotes clonogenic growth of glioblastoma via activation of TGF-β signaling

Author

Jeon, Hye-Min, primary, Shin, Yong Jae, additional, Lee, Jaehyun, additional, Chang, Nakho, additional, Woo, Dong-Hun, additional, Lee, Won Jun, additional, Nguyen, Dayna, additional, Kang, Wonyoung, additional, Cho, Hee Jin, additional, Yang, Heekyoung, additional, Lee, Jin-Ku, additional, Sa, Jason K., additional, Lee, Yeri, additional, Kim, Dong Geon, additional, Purow, Benjamin W., additional, Yoon, Yeup, additional, Nam, Do-Hyun, additional, and Lee, Jeongwu, additional

Published
2023
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17. Identifying predictors of glioma evolution from longitudinal sequencing

Author

Mu, Quanhua, primary, Chai, Ruichao, additional, Pang, Bo, additional, Yang, Yingxi, additional, Liu, Hanjie, additional, Zhao, Zheng, additional, Bao, Zhaoshi, additional, Song, Dong, additional, Zhu, Zhihan, additional, Yan, Mengli, additional, Jiang, Biaobin, additional, Mo, Zongchao, additional, Tang, Jihong, additional, Sa, Jason K., additional, Cho, Hee Jin, additional, Chang, Yuzhou, additional, Chan, Kaitlin Hao Yi, additional, Loi, Danson Shek Chun, additional, Tam, Sindy Sing Ting, additional, Chan, Aden Ka Yin, additional, Wu, Angela Ruohao, additional, Liu, Zhaoqi, additional, Poon, Wai Sang, additional, Ng, Ho Keung, additional, Chan, Danny Tat Ming, additional, Iavarone, Antonio, additional, Nam, Do-Hyun, additional, Jiang, Tao, additional, and Wang, Jiguang, additional

Published
2023
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21. Transcriptional regulatory networks of tumor-associated macrophages that drive malignancy in mesenchymal glioblastoma

Author

Sa, Jason K., Chang, Nakho, Lee, Hye Won, Cho, Hee Jin, Ceccarelli, Michele, Cerulo, Luigi, Yin, Jinlong, Kim, Sung Soo, Caruso, Francesca P., Lee, Mijeong, Kim, Donggeon, Oh, Young Taek, Lee, Yeri, Her, Nam-Gu, Min, Byeongkwi, Kim, Hye-Jin, Jeong, Da Eun, Kim, Hye-Mi, Kim, Hyunho, Chung, Seok, Woo, Hyun Goo, Lee, Jeongwu, Kong, Doo-Sik, Seol, Ho Jun, Lee, Jung-Il, Kim, Jinho, Park, Woong-Yang, Wang, Qianghu, Sulman, Erik P., Heimberger, Amy B., Lim, Michael, Park, Jong Bae, Iavarone, Antonio, Verhaak, Roel G. W., and Nam, Do-Hyun

Published
2020
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22. Neck Pain Disability on Headache Impact and the Association between Sleep Disturbance and Neck Pain in Migraine

Author

Cho, Hee-Jin Im, Yoo-Ha Hong, and Soo-Jin

Subjects
neck pain, migraine, primary headache, headache frequency, headache burden
Abstract

Neck pain (NP) is a prevalent symptom among migraine patients, but its disability on headache impact and the contributing factors for comorbid NP are poorly understood. This study aimed to investigate NP disability on the impact of headaches among migraineurs and factors linked to comorbid NP, including sleep-related variables. This cross-sectional study was conducted at a university hospital headache center, for headache patients at their first visits. Included in the study were 295 patients with migraines (217 females; 39.0  ±  10.8 years; 101 chronic migraine). Information on NP, history of physician-diagnosed cervical spine or disc disorders, detailed parameters of headache, and sleep and mood variables were collected. Logistic analysis of the severe impact of headache and contributing factors for NP were performed. NP was present in 153 participants (51.9%) with migraine, with high NP disability observed in 28 patients, and 125 patients had low NP disability. In multivariable analysis, NP disability, medication days per month, severe disability of migraine, and excessive daytime sleepiness were significant predictors for severe impact of headache. Thirty-seven patients with physician-diagnosed cervical spine or disc disorders were excluded from the NP analysis. Higher monthly headache days, female gender, and a high likelihood of obstructive sleep apnea were positively correlated with the presence of NP among migraineurs in multivariable analysis. Overall, the study highlights the potential impact of sleep-related variables and monthly headache days on NP in these patients. The high disability of NP was also associated with severe impact of headache.

Published
2023
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23. Pharmacogenomic landscape of patient-derived tumor cells informs precision oncology therapy

Author

Lee, Jin-Ku, Liu, Zhaoqi, Sa, Jason K., Shin, Sang, Wang, Jiguang, Bordyuh, Mykola, Cho, Hee Jin, Elliott, Oliver, Chu, Timothy, Choi, Seung Won, Rosenbloom, Daniel I. S., Lee, In-Hee, Shin, Yong Jae, Kang, Hyun Ju, Kim, Donggeon, Kim, Sun Young, Sim, Moon-Hee, Kim, Jusun, Lee, Taehyang, Seo, Yun Jee, Shin, Hyemi, Lee, Mijeong, Kim, Sung Heon, Kwon, Yong-Jun, Oh, Jeong-Woo, Song, Minsuk, Kim, Misuk, Kong, Doo-Sik, Choi, Jung Won, Seol, Ho Jun, Lee, Jung-Il, Kim, Seung Tae, Park, Joon Oh, Kim, Kyoung-Mee, Song, Sang-Yong, Lee, Jeong-Won, Kim, Hee-Cheol, Lee, Jeong Eon, Choi, Min Gew, Seo, Sung Wook, Shim, Young Mog, Zo, Jae Ill, Jeong, Byong Chang, Yoon, Yeup, Ryu, Gyu Ha, Kim, Nayoung K. D., Bae, Joon Seol, Park, Woong-Yang, Lee, Jeongwu, Verhaak, Roel G. W., Iavarone, Antonio, Lee, Jeeyun, Rabadan, Raul, and Nam, Do-Hyun

Published
2018
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24. Abstract CT038: Comprehensive molecular characterization of clinical response to durvalumab plus pazopanib combination in patients with advanced soft tissue sarcomas: A phase 2 clinical trial

Author

Cho, Hee Jin, primary, Yun, Kum-Hee, additional, Shin, Su-Jin, additional, Lee, Young Han, additional, Kim, Seung Hyun, additional, Baek, Wooyeol, additional, Han, Yoon Dae, additional, Kim, Sang Kyum, additional, Lee, JooHee, additional, Cho, Iksung, additional, Go, Heounjeong, additional, Ko, Jiwon, additional, Jung, Inkyung, additional, Jeon, Min Kyung, additional, Ryu, Hyang Joo, additional, Rha, Sun Young, additional, Kim, Hyo Song, additional, and Jun, Hyun Jung, additional

Published
2023
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30. Data from Transglutaminase 2 Inhibition Reverses Mesenchymal Transdifferentiation of Glioma Stem Cells by Regulating C/EBPβ Signaling

Author

Yin, Jinlong, primary, Oh, Young Taek, primary, Kim, Jeong-Yub, primary, Kim, Sung Soo, primary, Choi, Eunji, primary, Kim, Tae Hoon, primary, Hong, Jun Hee, primary, Chang, Nakho, primary, Cho, Hee Jin, primary, Sa, Jason K., primary, Kim, Jeong Cheol, primary, Kwon, Hyung Joon, primary, Park, Saewhan, primary, Lin, Weiwei, primary, Nakano, Ichiro, primary, Gwak, Ho-Shin, primary, Yoo, Heon, primary, Lee, Seung-Hoon, primary, Lee, Jeongwu, primary, Kim, Jong Heon, primary, Kim, Soo-Youl, primary, Nam, Do-Hyun, primary, Park, Myung-Jin, primary, and Park, Jong Bae, primary

Published
2023
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31. Supplementary Figure 1-3 from Transglutaminase 2 Inhibition Reverses Mesenchymal Transdifferentiation of Glioma Stem Cells by Regulating C/EBPβ Signaling

Author

Yin, Jinlong, primary, Oh, Young Taek, primary, Kim, Jeong-Yub, primary, Kim, Sung Soo, primary, Choi, Eunji, primary, Kim, Tae Hoon, primary, Hong, Jun Hee, primary, Chang, Nakho, primary, Cho, Hee Jin, primary, Sa, Jason K., primary, Kim, Jeong Cheol, primary, Kwon, Hyung Joon, primary, Park, Saewhan, primary, Lin, Weiwei, primary, Nakano, Ichiro, primary, Gwak, Ho-Shin, primary, Yoo, Heon, primary, Lee, Seung-Hoon, primary, Lee, Jeongwu, primary, Kim, Jong Heon, primary, Kim, Soo-Youl, primary, Nam, Do-Hyun, primary, Park, Myung-Jin, primary, and Park, Jong Bae, primary

Published
2023
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33. Integrated pharmaco-proteogenomics defines two subgroups in isocitrate dehydrogenase wild-type glioblastoma with prognostic and therapeutic opportunities

Author

Oh, Sejin, Yeom, Jeonghun, Cho, Hee Jin, Kim, Ju-Hwa, Yoon, Seon-Jin, Kim, Hakhyun, Sa, Jason K., Ju, Shinyeong, Lee, Hwanho, Oh, Myung Joon, Lee, Wonyeop, Kwon, Yumi, Li, Honglan, Choi, Seunghyuk, Han, Jang Hee, Chang, Jong Hee, Choi, Eunsuk, Kim, Jayeon, Her, Nam-Gu, Kim, Se Hoon, Kang, Seok-Gu, Paek, Eunok, Nam, Do-Hyun, Lee, Cheolju, and Kim, Hyun Seok

Published
2020
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34. Comprehensive pharmacogenomic characterization of gastric cancer

Author

Sa, Jason K., Hong, Jung Yong, Lee, In-Kyoung, Kim, Ju-sun, Sim, Moon-Hee, Kim, Ha Jung, An, Ji Yeong, Sohn, Tae Sung, Lee, Joon Ho, Bae, Jae Moon, Kim, Sung, Kim, Kyoung-Mee, Kim, Seung Tae, Park, Se Hoon, Park, Joon Oh, Lim, Ho Yeong, Kang, Won Ki, Her, Nam-Gu, Lee, Yeri, Cho, Hee Jin, Shin, Yong Jae, Kim, Misuk, Koo, Harim, Kim, Mirinae, Seo, Yun Jee, Kim, Ja Yeon, Choi, Min-Gew, Nam, Do-Hyun, and Lee, Jeeyun

Published
2020
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35. Pharmacogenomic analysis of patient-derived tumor cells in gynecologic cancers

Author

Sa, Jason K., Hwang, Jae Ryoung, Cho, Young-Jae, Ryu, Ji-Yoon, Choi, Jung-Joo, Jeong, Soo Young, Kim, Jihye, Kim, Myeong Seon, Paik, E. Sun, Lee, Yoo-Young, Choi, Chel Hun, Kim, Tae-Joong, Kim, Byoung-Gie, Bae, Duk-Soo, Lee, Yeri, Her, Nam-Gu, Shin, Yong Jae, Cho, Hee Jin, Kim, Ja Yeon, Seo, Yun Jee, Koo, Harim, Oh, Jeong-Woo, Lee, Taebum, Kim, Hyun-Soo, Song, Sang Yong, Bae, Joon Seol, Park, Woong-Yang, Han, Hee Dong, Ahn, Hyung Jun, Sood, Anil K., Rabadan, Raul, Lee, Jin-Ku, Nam, Do-Hyun, and Lee, Jeong-Won

Published
2019
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37. Graphene-Based Composite Materials for Chemical Sensor Application

Author

Kim, Il-Doo, Choi, Seon-Jin, Cho, Hee-Jin, Avouris, Phaedon, Series editor, Bhushan, Bharat, Series editor, Bimberg, Dieter, Series editor, von Klitzing, Klaus, Series editor, Wiesendanger, Roland, Series editor, Macagnano, Antonella, editor, Zampetti, Emiliano, editor, and Kny, Erich, editor

Published
2015
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38. Phase II Trial with Correlative Genomic Analysis of Durvalumab Plus Pazopanib Combination in Patients with Advanced Soft Tissue Sarcomas

Author

Cho, Hee Jin, primary, Yun, Kum-Hee, additional, Shin, Su-Jin, additional, Lee, Young Han, additional, Kim, Seung Hyun, additional, Baek, Wooyeol, additional, Han, Yoon Dae, additional, Kim, Sang Kyum, additional, Ryu, Hyang Joo, additional, Lee, Joohee, additional, Cho, Iksung, additional, Go, Heounjeong, additional, Ko, Jiwon, additional, Jung, Inkyung, additional, Jeon, Min Kyung, additional, Rha, Sun Young, additional, and Kim, Hyo Song, additional

Published
2023
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39. Additional file 2 of Pharmacogenomic profiling reveals molecular features of chemotherapy resistance in IDH wild-type primary glioblastoma

Author

Nam, Yoonhee, Koo, Harim, Yang, Yingxi, Shin, Sang, Zhu, Zhihan, Kim, Donggeon, Cho, Hee Jin, Mu, Quanhua, Choi, Seung Won, Sa, Jason K., Seo, Yun Jee, Kim, Yejin, Lee, Kyoungmin, Oh, Jeong-Woo, Kwon, Yong-Jun, Park, Woong-Yang, Kong, Doo-Sik, Seol, Ho Jun, Lee, Jung-Il, Park, Chul-Kee, Lee, Hye Won, Yoon, Yeup, and Wang, Jiguang

Abstract

Additional file 2: Fig. S1. Timeline of sample acquisition, sequencing, in vitro culture and TMZ screening. Fig. S2. Gaussian Mixture Model used to identify genes with the same expression profile between patient-derived cells (PDCs) and tumor tissues. Fig. S3. Principal Component Analysis and differentially expressed gene analysis on 34 tissue RNA-seq samples. Fig. S4. Association of MGMT promoter methylation status to survival and in vitro TMZ screening in the main cohort. Fig. S5. Copy number estimation by GliomaSCAN. Fig. S6. Copy number estimation by RNA-seq. Fig. S7. Machine learning model feature importance. Fig. S8. Correlations between GBM subtypes and TMZ response. Fig. S9. Comparison of survival prediction in TCGA cohort. Fig. S10. Genomic landscape of multi-sector samples. Fig. S11. TMZ-resistant marker expression and CNV comparison in patient M13 and M14. Fig. S12. Progression free survival difference in patients with multi-sector samples.

Published
2023
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40. Additional file 3 of Pharmacogenomic profiling reveals molecular features of chemotherapy resistance in IDH wild-type primary glioblastoma

Author

Nam, Yoonhee, Koo, Harim, Yang, Yingxi, Shin, Sang, Zhu, Zhihan, Kim, Donggeon, Cho, Hee Jin, Mu, Quanhua, Choi, Seung Won, Sa, Jason K., Seo, Yun Jee, Kim, Yejin, Lee, Kyoungmin, Oh, Jeong-Woo, Kwon, Yong-Jun, Park, Woong-Yang, Kong, Doo-Sik, Seol, Ho Jun, Lee, Jung-Il, Park, Chul-Kee, Lee, Hye Won, Yoon, Yeup, and Wang, Jiguang

Abstract

Additional file 3. Supplementary methods.

Published
2023
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46. Recapitulated Crosstalk between Cerebral Metastatic Lung Cancer Cells and Brain Perivascular Tumor Microenvironment in a Microfluidic Co‐Culture Chip (Adv. Sci. 22/2022)

Author

Kim, Hyunho, primary, Sa, Jason K., additional, Kim, Jaehoon, additional, Cho, Hee Jin, additional, Oh, Hyun Jeong, additional, Choi, Dong‐Hee, additional, Kang, Seok‐Hyeon, additional, Jeong, Da Eun, additional, Nam, Do‐Hyun, additional, Lee, Hakho, additional, Lee, Hye Won, additional, and Chung, Seok, additional

Published
2022
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47. Characteristics of spinal and bulbar muscular atrophy in South Korea: a cross-sectional study of 157 patients.

Author

Cho, Hee-Jin, Shin, Jin-Hong, Park, Young-Eun, Sohn, Eunhee, Nam, Tai-Seung, Kang, Min-Gu, Park, Jin-Mo, Park, Donghwi, and Park, Jin-Sung

Subjects
*SPINAL muscular atrophy, *AMYOTROPHIC lateral sclerosis, *CARPAL tunnel syndrome, *SPINOCEREBELLAR ataxia, *ANDROGEN receptors, *X chromosome, *KOREANS
Abstract

Spinal and bulbar muscular atrophy, namely Kennedy disease, is a rare progressive neurodegenerative disorder caused by the expansion of a CAG repeat in the first exon of the androgen receptor gene on the X chromosome. We assessed the clinical history, laboratory findings, functional scales and electrophysiological data, as well as the levels of luteinizing hormone, follicle-stimulating hormone and testosterone, in 157 Korean patients with genetically confirmed spinal and bulbar muscular atrophy (mean age at data collection = 56.9 years; range = 33–83 years). Hand tremor was the first symptom noticed by patients at a median age of 35 years, followed by gynaecomastia, orofacial fasciculation, cramps and fatigability in ascending order. Clinical symptoms such as paraesthesia and dysphagia appeared during the later stages of the disease. Cane use during ambulation began at a median age of 62 years. There were statistically significant differences between patients and controls in the results of sensory nerve studies, motor conduction velocity, and distal latencies. Furthermore, among the hormone markers analysed, the level of luteinizing hormone exhibited a negative correlation with the spinal and bulbar muscular atrophy functional rating scale, Korean version. However, among the patients with a disease duration of ≤5 years, the levels of luteinizing hormone showed a significant correlation with assessments using the amyotrophic lateral sclerosis functional rating scale-revised, spinal and bulbar muscular atrophy functional rating scale, Korean version and the 6-minute walk test. In conclusion, our findings provide clinical information from a substantial number of patients with spinal and bulbar muscular atrophy in Korea that accorded with that of patients with this disease worldwide but with updated clinical features. [ABSTRACT FROM AUTHOR]

Published
2023
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