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11 results on '"Cho, Hae-Ra"'

4. XB130 Deficiency Causes Congenital Hypothyroidism in Mice due to Disorganized Apical Membrane Structure and Function of Thyrocytes

Author

Wang, Yingchun, primary, Shimizu, Hiroki, additional, Xiang, Yun-Yan, additional, Sugihara, Junichi, additional, Lu, Wei-Yang, additional, Liao, Xiao-Hui, additional, Cho, Hae-Ra, additional, Toba, Hiroaki, additional, Bai, Xiao-Hui, additional, Asa, Sylvia L., additional, Arvan, Peter, additional, Refetoff, Samuel, additional, and Liu, Mingyao, additional

Published
2021
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6. Pentraxin 3 deficiency enhances features of chronic rejection in a mouse orthotopic lung transplantation model

Author

Yoshida, Mitsuteru, Oishi, Hisashi, Martinu, Tereza, Hwang, David M., Takizawa, Hiromitsu, Sugihara, Junichi, McKee, Trevor D., Bai, Xiaohui, Guana, Zehong, Lua, Christina, Cho, Hae-Ra, Juvet, Stephen, Cypel, Marcelo, Keshavjee, Shaf, Liu, Mingyao, Yoshida, Mitsuteru, Oishi, Hisashi, Martinu, Tereza, Hwang, David M., Takizawa, Hiromitsu, Sugihara, Junichi, McKee, Trevor D., Bai, Xiaohui, Guana, Zehong, Lua, Christina, Cho, Hae-Ra, Juvet, Stephen, Cypel, Marcelo, Keshavjee, Shaf, and Liu, Mingyao

Abstract

Chronic lung allograft dysfunction (CLAD) is a serious complication after lung transplantation and thought to represent chronic rejection. Increased expression of Pentraxin 3 (PTX3), an acute phase protein, was associated with worse outcome in lung transplant patients. To determine the role of recipient PTX3 in development of chronic rejection, we used a minor alloantigen-mismatched murine orthotopic single lung transplant model. Male C57BL/10 mice were used as donors. Male PTX3 knockout (KO) mice and their wild type (WT) littermates on 129/SvEv/C57BL6/J background were used as recipients. In KO recipients, 7/13 grafted lungs were consolidated without volume recovery on CT scan, while only 2/9 WT mice showed similar graft consolidation. For grafts where lung volume could be reliably analyzed by CT scan, the lung volume recovery was significantly reduced in KO mice compared to WT. Interstitial inflammation, parenchymal fibrosis and bronchiolitis obliterans scores were significantly higher in KO mice. Presence of myofibroblasts and lymphoid aggregation was significantly enhanced in the grafts of PTX3 KO recipients. Recipient PTX3 deficiency enhanced chronic rejection-like lesions by promoting a fibrotic process in the airways and lung parenchyma. The underlying mechanisms and potential protective role of exogenous PTX3 as a therapy should be further explored.

Published
2018

7. Pentraxin 3 deficiency enhances features of chronic rejection in a mouse orthotopic lung transplantation model

Author

Yoshida, Mitsuteru, primary, Oishi, Hisashi, additional, Martinu, Tereza, additional, Hwang, David M., additional, Takizawa, Hiromitsu, additional, Sugihara, Junichi, additional, McKee, Trevor D., additional, Bai, Xiaohui, additional, Guana, Zehong, additional, Lua, Christina, additional, Cho, Hae-Ra, additional, Juvet, Stephen, additional, Cypel, Marcelo, additional, Keshavjee, Shaf, additional, and Liu, Mingyao, additional

Published
2018
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9. XB130—A Novel Adaptor Protein: Gene, Function, and Roles in Tumorigenesis

Author

Bai, Xiao-Hui, Cho, Hae-Ra, Moodley, Serisha, and Liu, Mingyao

Subjects
Article Subject
Abstract

Several adaptor proteins have previously been shown to play an important role in the promotion of tumourigenesis. XB130 (AFAP1L2) is an adaptor protein involved in many cellular functions, such as cell survival, cell proliferation, migration, and gene and miRNA expression. XB130’s functional domains and motifs enable its interaction with a multitude of proteins involved in several different signaling pathways. As a tyrosine kinase substrate, tyrosine phosphorylated XB130 associates with the p85α regulatory subunit of phosphoinositol-3-kinase (PI3K) and subsequently affects Akt activity and its downstream signalling. Tumourigenesis studies show that downregulation of XB130 expression by RNAi inhibits tumor growth in mouse xenograft models. Furthermore, XB130 affects tumor oncogenicity by regulating the expression of specific tumour suppressing miRNAs. The expression level and pattern of XB130 has been studied in various human tumors, such as thyroid, esophageal, and gastric cancers, as well as, soft tissue tumors. Studies show the significant effects of XB130 in tumourigenesis and suggest its potential as a diagnostic biomarker and therapeutic target for cancer treatments.

Published
2014
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