1. [Pulmonary aspergillosis in a child with chronic granulomatous disease].
- Author
-
Abdelmoula MS, Abdelmalek R, Chleyfa K, Bejaoui M, Tebib N, Ben Turkia H, and Ben Dridi MF
- Subjects
- Child, Humans, Male, Aspergillosis complications, Granulomatous Disease, Chronic complications, Lung Diseases, Fungal complications
- Abstract
The chronic granulomatous disease is characterised by the occurence of multiple bacterial and fungal infections since the early childhood. This susceptibility to infections must be prevented by a primary prophlylaxis against the opportunistic germs like pneumocystis and aspergillus. Our case is about a twelve-year-old boy who had a prophylaxis since his fourth month of life. At 10 years he presented a pleuro-pneumonia refractory to a large spectrum antibiotherapy. The aspergillar etiology was established on clinical, radiological and serological arguments. An amphotericine B treatment allowed a good clinical and radiological outcome of this pleuro-pulmonary affection. However, a dorsal spondylodiscitis complicated the course of the disease. A secondary vertebral aspergillosis or a Pott's disease were suspected. The vertebral bipsy was'nt conclusive. The association of antituberculous and antifungal agents with adjuvant molecules (IFN, granulotic transfusions and GM-CSF) permitted a good clinical outcome and the stabilisation of the radiological lesions.
- Published
- 2003