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1. Embryonic Hematopoietic Progenitor Cells Reside in Muscle before Bone Marrow Hematopoiesis.

Author

Yuka Tanaka, Tomoko Inoue-Yokoo, Kasem Kulkeaw, Chiyo Yanagi-Mizuochi, Senji Shirasawa, Yoichi Nakanishi, and Daisuke Sugiyama

Subjects
Medicine, Science
Abstract

In mice, hematopoietic cells home to bone marrow from fetal liver prenatally. To elucidate mechanisms underlying homing, we performed immunohistochemistry with the hematopoietic cell marker c-Kit, and observed c-Kit(+) cells localized inside muscle surrounding bone after 14.5 days post coitum. Flow cytometric analysis showed that CD45(+) c-Kit(+) hematopoietic cells were more abundant in muscle than in bone marrow between 14.5 and 17.5 days post coitum, peaking at 16.5 days post coitum. CD45(+) c-Kit(+) cells in muscle at 16.5 days post coitum exhibited higher expression of Gata2, among several hematopoietic genes, than did fetal liver or bone marrow cells. Colony formation assays revealed that muscle hematopoietic cells possess hematopoietic progenitor activity. Furthermore, exo utero transplantation revealed that fetal liver hematopoietic progenitor cells home to muscle and then to BM. Our findings demonstrate that hematopoietic progenitor cell homing occurs earlier than previously reported and that hematopoietic progenitor cells reside in muscle tissue before bone marrow hematopoiesis occurs during mouse embryogenesis.

Published
2015
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2. Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells

Author

Christine L. Mummery, Hiroshi Kawamoto, Mitsuru Morimoto, Hiroki Sato, Misako Yoneda, Kim M. Summers, Haruhiko Koseki, Carsten O. Daub, Imad Abugessaisa, Olga Hrydziuszko, Akira Hasegawa, Afsaneh Eslami, J Kenneth Baillie, Dan Goldowitz, Frank Brombacher, Piero Carninci, Thomas J. Ha, Tomokatsu Ikawa, Peter G. Zhang, Andru Tomoiu, Erik Arner, Robin Andersson, Soichi Kojima, Margaret Patrikakis, Andreas Lennartsson, Christine A. Wells, Valerio Orlando, Miki Kojima, Lesley M. Forrester, Peter Arner, Marina Lizio, Christopher J. Mungall, Geoffrey J. Faulkner, Berit Lilje, David A. Hume, Takeya Kasukawa, Hideya Kawaji, Louise N. Winteringham, Soichi Ogishima, Kristoffer Vitting-Seerup, Jayson Harshbarger, Michael Detmar, Anita Schwegmann, Yasushi Okazaki, Rolf Swoboda, Alka Saxena, Jun Kawai, Hiromi Nishiyori-Sueki, Mitsuko Hara, Yoshihide Hayashizaki, Ernst J. Wolvetang, Chieko Kai, Naoto Kondo, Richard A Axton, Albin Sandelin, James Briggs, Yutaka Nakachi, Dmitry A. Ovchinnikov, Carmelo Ferrai, Mitsuyoshi Murata, Masayoshi Itoh, Finn Drabløs, Anthony G Beckhouse, Lynsey Fairbairn, Meenhard Herlyn, Mariko Okada-Hatakeyama, Beatrice Bodega, Susan E. Zabierowski, Morana Vitezic, Michiel J. L. de Hoon, Masaaki Furuno, Ana Pombo, Reto Guler, Hiroshi Tanaka, Alistair R. R. Forrest, Serkan Sahin, Timo Lassmann, Robert Passier, S. Peter Klinken, Tom C. Freeman, Alexander D. Diehl, Niklas Mejhert, Anna Ehrlund, Ken Miyaguchi, Michela Fagiolini, Nicolas Bertin, Michelle Rönnerblad, Sayaka Nagao-Sato, Levon M. Khachigian, Mitsuhiro Endoh, Margaret B. Davis, Shiro Fukuda, Daisuke Sugiyama, Xian-Yang Qin, Malcolm E. Fisher, Yosuke Mizuno, Jessica Severin, Sarah Klein, Suzana Savvi, Kelly J. Morris, Terrence F. Meehan, Yuri Ishizu, Fumi Hori, Ahmad M. N. Alhendi, Sachi Ishikawa-Kato, Tsugumi Kawashima, Harukazu Suzuki, Sugata Roy, and Chiyo Yanagi-Mizuochi

Subjects
Transcription, Genetic, Cellular differentiation, Enhancer RNAs, Biology, Article, Mice, Dogs, Transcription (biology), Animals, RNA, Messenger, Enhancer, Gene, Transcription factor, Genetics, Regulation of gene expression, Multidisciplinary, Binding Sites, Stem Cells, Gene Expression Regulation, Developmental, Promoter, Cell Differentiation, Cell biology, Rats, Enhancer Elements, Genetic, Cattle, Transcription Factors
Abstract

Uncaging promoter and enhancer dynamics In order to understand cellular differentiation, it is important to understand the timing of the regulation of gene expression. Arner et al. used cap analysis of gene expression (CAGE) to analyze gene enhancer and promoter activities in a number of human and mouse cell types. The RNA of enhancers was transcribed first, followed by that of transcription factors, and finally by genes that are not transcription factors. Science , this issue p. 1010

Published
2015

3. FANTOM5 CAGE profiles of human and mouse samples

Author

Jun Kawai, Anthony G Beckhouse, Dipti Vijayan, Michael Rehli, Toshiyuki Nakamura, Yuki Hasegawa, Timothy C. Barnett, Hisashi Shimoji, Erik Arner, Masayoshi Itoh, Masahide Hamaguchi, Sarah Klein, Reto Guler, Patrizia Rizzu, Atsutaka Kubosaki, Soichi Kojima, Timo Lassmann, Kelly J. Morris, Mutsumi Kanamori-Katayama, Ri Ichiroh Manabe, Hiromasa Morikawa, Kelly J Hitchens, Fumi Hori, Linda M. van den Berg, Yasushi Okazaki, Andru Tomoiu, Antti Sajantila, Akiko Saka, Thierry Sengstag, Alessandro Bonetti, Haruhiko Koseki, Matthias Edinger, Mitsuhiro Ohshima, Carsten O. Daub, Jayson Harshbarger, Sachi Ishikawa-Kato, Tsugumi Kawashima, Christine L. Mummery, Niklas Mejhert, Jun Takai, Dan Goldowitz, Naoko Suzuki, Guojun Sheng, David A. Hume, Hiroshi Kawamoto, Ai Kaiho, Jun Ichi Furusawa, Ailsa J Carlisle, Tomokatsu Ikawa, Shiro Fukuda, Peter G. Zhang, Akira Hasegawa, James Briggs, Toshio Kitamura, Alistair R. R. Forrest, Takahiro Arakawa, Marcvande Wetering, Shohei Noma, Fumio Nakahara, Jessica Severin, Sven Guhl, Atsushi Kondo, Mary C. Farach-Carson, Hans Clevers, Afsaneh Eslami, Christian Schmidl, Peter Heutink, Hideki Tatsukawa, Anita Schwegmann, Noriko Ninomiya, Antje Blumenthal, Yoshihide Hayashizaki, Suzana Savvi, Thomas J. Ha, Claudio Schneider, Daisuke Sugiyama, Hironori Satoh, Mitsuru Morimoto, Hiroki Sato, Yosuke Mizuno, Meenhard Herlyn, Hozumi Motohashi, Shigehiro Yoshida, Hiroo Toyoda, Christophe Simon, Piero Carninci, Tadasuke Nozaki, Hideya Kawaji, Louise N. Winteringham, Swati Pradhan-Bhatt, Imad Abugessaisa, Michihira Tagami, Tony J. Kenna, Yoko Yamaguchi, Geoffrey J. Faulkner, Alka Saxena, Naoto Kondo, Dmitry A. Ovchinnikov, Rie Fujita, Ernst J. Wolvetang, Michael Detmar, Miki Kojima, Peter Arner, Mitsuko Hara, Stefano Gustincich, Carrie A. Davis, Judith S. Kempfle, Margaret Patrikakis, Alan Mackay-Sim, Carmelo Ferrai, Yutaka Nakachi, Juha Kere, Mitsuyoshi Murata, Shimon Sakaguchi, Soichi Ogishima, Silvia Zucchelli, Andreas Lennartsson, Thomas R. Gingeras, Masanori Suzuki, Beatrice Bodega, Sugata Roy, Sayaka Nagao-Sato, Mitsuhiro Endoh, Anna Ehrlund, J Kenneth Baillie, Mizuho Sakai, Michela Fagiolini, Taeko Dohi, Christine A. Wells, Frank Brombacher, Masayuki Yamamoto, Robert Passier, Lynsey Fairbairn, Teunis B. H. Geijtenbeek, Shigeo Koyasu, Hiromi Nishiyori-Sueki, Yuri Ishizu, Yuki I. Kawamura, Chiyo Yanagi-Mizuochi, Roberto Verardo, Misako Yoneda, Mariko Okada-Hatakeyama, Kaoru Kaida, Ana Pombo, Gundula Schulze-Tanzil, Lesley M. Forrester, Kim M. Summers, Harukazu Suzuki, Naganari Ohkura, Weon Ju Lee, Hiroshi Tanaka, Alan J. Knox, Karl Ekwall, Yukio Nakamura, Serkan Sahin, Shuhei Noguchi, Hiroshi Ohno, Yohei Yonekura, Richard A Axton, Marina Lizio, S. Peter Klinken, Malcolm E. Fisher, Shoko Watanabe, Magda Babina, Xian-Yang Qin, Takaaki Sugiyama, B. Albert S. Edge, Eri Saijyo, Valerio Orlando, Takeya Kasukawa, Kazuyo Moro, Kenichi Nakazato, Naoko Takahashi, Levon M. Khachigian, Chieko Kai, Masaaki Furuno, Jay W. Shin, Hideki Enomoto, Hubrecht Institute for Developmental Biology and Stem Cell Research, AII - Infectious diseases, Infectious diseases, and AII - Amsterdam institute for Infection and Immunity

Subjects
0301 basic medicine, 500 Naturwissenschaften und Mathematik::570 Biowissenschaften, Biologie, Data Descriptor, Molecular biology, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit, Genome, Mice, 0302 clinical medicine, Transcription (biology), Promoter Regions, Genetic, Non-U.S. Gov't, Regulation of gene expression, Research Support, Non-U.S. Gov't, Statistics, Computer Science Applications1707 Computer Vision and Pattern Recognition, Computer Science Applications, Library and Information Sciences, Information Systems, Statistics, Probability and Uncertainty, Statistics and Probability, ddc:500, Cell activation, Systems biology, Cell biology, Computational biology, Biology, Research Support, Education, 03 medical and health sciences, Species Specificity, Developmental biology, Journal Article, Animals, Humans, Enhancer, Gene Expression Profiling, Promoter, Cap analysis gene expression, Computational biology and bioinformatics, Gene expression profiling, 030104 developmental biology, Gene Expression Regulation, Cardiovascular and Metabolic Diseases, Probability and Uncertainty, 030217 neurology & neurosurgery
Abstract

Scientific Data, 4, ISSN:2052-4463

Published
2017
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4. Embryonic Hematopoietic Progenitor Cells Reside in Muscle before Bone Marrow Hematopoiesis

Author

Kasem Kulkeaw, Yoichi Nakanishi, Daisuke Sugiyama, Chiyo Yanagi-Mizuochi, Senji Shirasawa, Tomoko Inoue-Yokoo, and Yuka Tanaka

Subjects
Male, Time Factors, Green Fluorescent Proteins, CD34, lcsh:Medicine, Bone Marrow Cells, Mice, Transgenic, Biology, Andrology, Colony-Forming Units Assay, Organ Culture Techniques, Bone Marrow, medicine, Myocyte, Animals, lcsh:Science, Embryonic Stem Cells, Multidisciplinary, Microscopy, Confocal, Reverse Transcriptase Polymerase Chain Reaction, Muscles, GATA2, lcsh:R, Days post coitum, Gene Expression Regulation, Developmental, Flow Cytometry, Hematopoietic Stem Cells, Embryonic stem cell, Molecular biology, Hematopoiesis, GATA2 Transcription Factor, Mice, Inbred C57BL, Haematopoiesis, Proto-Oncogene Proteins c-kit, medicine.anatomical_structure, Liver, embryonic structures, Leukocyte Common Antigens, Female, lcsh:Q, Bone marrow, Homing (hematopoietic), Research Article
Abstract

In mice, hematopoietic cells home to bone marrow from fetal liver prenatally. To elucidate mechanisms underlying homing, we performed immunohistochemistry with the hematopoietic cell marker c-Kit, and observed c-Kit(+) cells localized inside muscle surrounding bone after 14.5 days post coitum. Flow cytometric analysis showed that CD45(+) c-Kit(+) hematopoietic cells were more abundant in muscle than in bone marrow between 14.5 and 17.5 days post coitum, peaking at 16.5 days post coitum. CD45(+) c-Kit(+) cells in muscle at 16.5 days post coitum exhibited higher expression of Gata2, among several hematopoietic genes, than did fetal liver or bone marrow cells. Colony formation assays revealed that muscle hematopoietic cells possess hematopoietic progenitor activity. Furthermore, exo utero transplantation revealed that fetal liver hematopoietic progenitor cells home to muscle and then to BM. Our findings demonstrate that hematopoietic progenitor cell homing occurs earlier than previously reported and that hematopoietic progenitor cells reside in muscle tissue before bone marrow hematopoiesis occurs during mouse embryogenesis.

Published
2015

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