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178 results on '"Chiu Chun-Hsiang"'

5. Recommendations and guidelines for the treatment of Clostridioides difficile infection in Taiwan

Author

Wu, Kuan-Sheng, Syue, Ling-Shan, Cheng, Aristine, Yen, Ting-Yu, Chen, Hsien-Meng, Chiu, Yu-Hsin, Hsu, Yu-Lung, Chiu, Chun-Hsiang, Su, Ting-Yi, Tsai, Wan-Lin, Chen, Wei-Yu, Huang, Chung-Hao, Hung, Huei-Min, Huang, Ling-Ju, Kuo, Hong-Jie, Lin, Pei-Chin, Yang, Ching-Hsiang, Hong, Pi-Lien, Lee, Susan Shin-Jung, Chen, Yao-Shen, Liu, Yung-Ching, and Huang, Li-Ming

Published
2020
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30. Rapid establishment of a COVID-19 biobank in NHRI by National Biobank Consortium of Taiwan

Author

Huang, Shiu-Feng, primary, Huang, Yhu-Chering, additional, Chang, Feng-Yee, additional, Lin, Jung-Chung, additional, Chiu, Chun-Hsiang, additional, Chen, Chien-Wen, additional, Wang, Fu-Der, additional, Chiu, Yen-Ling, additional, Cheng, Shu-Hsing, additional, Cheng, Chien-Yu, additional, Lin, Yi-Chun, additional, Chen, Cheng-Pin, additional, Huang, Chien-Hsien, additional, Liu, Po-Yu, additional, Lee, Yuan-Ti, additional, Lee, Chen-Hsiang, additional, Chen, Yao-Shen, additional, Sy, Cheng-Len, additional, Tseng, Yu-Ting, additional, Hsu, Cheng-Ting, additional, Tseng, Chia-Chun, additional, Lee, Yu-Lin, additional, Liu, Chun-Eng, additional, and Sytwu, Huey-Kang, additional

Published
2020
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38. Thickness-Optimized Multilevel Resistive Switching of Silver Programmable Metallization Cells With Stacked SiO x /SiO2 Solid Electrolytes

Author

Chiu Chun-Hsiang, Jer-Chyi Wang, and Chen Wei-Fan

Subjects
Materials science, Silicon, business.industry, Electrical engineering, chemistry.chemical_element, Capacitance, Electronic, Optical and Magnetic Materials, Non-volatile memory, chemistry, Resistive switching, Fast ion conductor, Optoelectronics, Electrical and Electronic Engineering, business, Low resistance, Silicon oxide, Order of magnitude
Abstract

Multilevel resistive switching (RS) characteristics of silver programmable metallization cells (Ag-PMCs) with stacked SiO x /SiO2 solid electrolytes have been investigated. Combined with conventional high/low resistance states and additional two middle resistance states (MRS1/MRS2), a multilevel cell operation of stacked-solid-electrolyte Ag-PMCs is achieved and optimized by the film thickness. Furthermore, the RS mechanism at middle resistance states has been proposed to be locally discontinuous Ag conductive filament (Ag-CF) within the stacked solid electrolytes by examining the carrier transportation and two-frequency calibrated capacitance. The stacked silicon oxide layers can prevent the Ag-CF from regeneration during the multilevel retention test, contributing to the superior retention properties to more than $10^{4}$ s at 125 °C. In addition, a sequentially multilevel cycling test of more than $10^{3}$ times with a resistance ratio of two orders of magnitude between each resistance state is realized by the stacked-solid-electrolyte Ag-PMCs, suitable for future high-density nonvolatile memory applications.

Published
2015

39. In vitro and in vivo activities of imipenem combined with BLI-489 against class D β-lactamase-producing Acinetobacter baumannii.

Author

Wang, Yung-Chih, Huang, Shu-Wei, Chiang, Ming-Hsien, Lee, I-Ming, Kuo, Shu-Chen, Yang, Ya-Sung, Chiu, Chun-Hsiang, Su, Ying-Shih, Chen, Te-Li, Wang, Fu-Der, and Lee, Yi-Tzu

Subjects
ACINETOBACTER baumannii, CARBAPENEM-resistant bacteria, IMIPENEM, CAENORHABDITIS elegans, GENES, BINDING sites
Abstract

Background: According to our preliminary study, BLI-489 has the potential to inhibit the hydrolysing activity of OXA-51-like β-lactamase produced by carbapenem-resistant Acinetobacter baumannii (CRAb).Objectives: In the present study, the in vitro and in vivo activities of imipenem combined with BLI-489 against CRAb producing carbapenem-hydrolysing class D β-lactamases (CHDLs), namely OXA-23, OXA-24, OXA-51 and OXA-58, were determined.Methods: A chequerboard analysis of imipenem and BLI-489 was performed using 57 and 7 clinical CRAb isolates producing different CHDLs and MBLs, respectively. Four representative strains harbouring different CHDL genes were subjected to a time-kill assay to evaluate the synergistic effects. An in silico docking analysis was conducted to simulate the interactions between BLI-489 and the different families of CHDLs. The in vivo activities of this combination were assessed using a Caenorhabditis elegans survival assay and a mouse pneumonia model.Results: Chequerboard analysis showed that imipenem and BLI-489 had a synergistic effect on 14.3, 92.9, 100, 16.7 and 100% of MBL-, OXA-23-, OXA-24-like-, OXA-51-like- and OXA-58-producing CRAb isolates, respectively. In the time-kill assay, imipenem and BLI-489 showed synergy against OXA-24-like-, OXA-51-like- and OXA-58-, but not OXA-23-producing CRAb isolates after 24 h. The in silico docking analysis showed that BLI-489 could bind to the active sites of OXA-24 and OXA-58 to confer strong inhibition activity. The combination of imipenem and BLI-489 exhibited synergistic effects for the rescue of CRAb-infected C. elegans and mice.Conclusions: Imipenem combined with BLI-489 has synergistic effects against CHDL-producing CRAb isolates. [ABSTRACT FROM AUTHOR]

Published
2021
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44. Leptospirosis and Depression

Author

Chiu, Chun-Hsiang, primary, Wang, Ying-Chuan, additional, Lin, Cheng-Li, additional, Lee, Feng-You, additional, and Kao, Chia-Hung, additional

Published
2017
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45. The effectiveness of the telehomecare for self-care behaviors of patients with diabetes in Taiwan: A consecutive observational study

Author

Liu, Chieh-Hsing, primary, Chiu, Szu-Han, additional, Hsiao, Po-Jen, additional, Chan, Jenq-Shyong, additional, Lin, Hung-Che, additional, Tu, Hsiu-Mei, additional, Cheng, Chih-Jen, additional, Shih, Cheng-Ping, additional, Lin, Yuan-Yung, additional, Chiu, Chun-Hsiang, additional, Wang, Chih-Chien, additional, and Tung, Chen-Yin, additional

Published
2017
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47. Recommendations and guidelines for the treatment of Clostridioides difficileinfection in Taiwan

Author

Wu, Kuan-Sheng, Syue, Ling-Shan, Cheng, Aristine, Yen, Ting-Yu, Chen, Hsien-Meng, Chiu, Yu-Hsin, Hsu, Yu-Lung, Chiu, Chun-Hsiang, Su, Ting-Yi, Tsai, Wan-Lin, Chen, Wei-Yu, Huang, Chung-Hao, Hung, Huei-Min, Huang, Ling-Ju, Kuo, Hong-Jie, Lin, Pei-Chin, Yang, Ching-Hsiang, Hong, Pi-Lien, Lee, Susan Shin-Jung, Chen, Yao-Shen, Liu, Yung-Ching, and Huang, Li-Ming

Abstract

Clostridioides difficileinfection (CDI) is a major enteric disease associated with antibiotic use and a leading cause of hospital-acquired infections worldwide. This is the first guideline for treatment of CDI in Taiwan, aiming to optimize medical care for patients with CDI. The target audience of this document includes all healthcare personnel who are involved in the medical care of patients with CDI. The 2018 Guidelines Recommendations for Evidence-based Antimicrobial agents use in Taiwan (GREAT) working group was formed, comprising of infectious disease specialists from 13 medical centers in Taiwan, to review the evidence and draft recommendations using the grading of recommendations assessment, development, and evaluation (GRADE) methodology. A nationwide expert panel reviewed the recommendations during a consensus meeting in March 2019. The recommendation is endorsed by the Infectious Diseases Society of Taiwan (IDST). This guideline describes the epidemiology and risk factors of CDI, and provides recommendations for treatment of CDI in both adults and children. Recommendations for treatment of the first episode of CDI, first recurrence, second and subsequent recurrences of CDI, severe CDI, fulminant CDI, and pediatric CDI are provided.

Published
2020
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48. Bacterial membrane vesicles from Acinetobacter baumanniiinduced by ceftazidime are more virulent than those induced by imipenem

Author

Chiu, Chun-Hsiang, Lee, Yi-Tzu, Lin, Yu-Chun, Kuo, Shu-Chen, Yang, Ya-Sung, Wang, Yung-Chih, Liu, Yu-Han, Lin, Jung-Chung, Chang, Feng-Yee, and Chen, Te-Li

Abstract

ABSTRACTPatients with Acinetobacter baumanniibacteremia treated with antipseudomonal cephalosporins showed higher 14-day mortality than patients treated with antipseudomonal carbapenems. We hypothesized that the bacterial membrane vesicles (BMVs) induced by antipseudomonal cephalosporins are more virulent than BMVs induced by antipseudomonal carbapenems.To simulate the clinical condition with inadequate antimicrobial treatment, carbapenem-resistant A. baumanniiwas treated with ceftazidime (an antipseudomonal cephalosporin) or imipenem (an antipseudomonal carbapenem) at 1/2 the minimum inhibitory concentration. BMVs and BMV-carried lipopolysaccharide were measured by nanoparticle tracking analysis and western blotting, respectively. Cytokine expression in RAW264.7 macrophages or mice serum induced by the BMVs was determined by ELISA, fluorescent bead-based immunoassay or western blotting. The virulence of the BMVs was assessed in mice. Liquid chromatography tandem-mass spectrometry was used to determine the protein contents of the BMVs.We found that ceftazidime induced a higher number of BMVs (CAZ-BMV), which carried more LPS, and induced higher expression levels of iNOS, IL-1β, and IL-6 in macrophages, higher expression of many cytokines in mice, more neutrophil infiltration in lung interstitium, and higher mortality in mice than imipenem-induced BMVs (IMP-BMV). When adjusted to same amount of LPS, CAZ-BMV still led to higher mortality than IMP-BMV. Proteomic analysis revealed different protein contents in CAZ-BMV and IMP-BMV. In conclusion, A. baumanniiBMVs induced by ceftazidime are more virulent than BMVs induced by imipenem.

Published
2020
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