194 results on '"Chiu, Francis"'
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2. An in vitro toolbox to accelerate anti-malarial drug discovery and development
3. Using Human Plasma as an Assay Medium in Caco-2 Studies Improves Mass Balance for Lipophilic Compounds
4. Metabolic, Pharmacokinetic, and Activity Profile of the Liver Stage Antimalarial (RC-12)
5. Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria
6. Simultaneous determination of OZ277, a synthetic 1,2,4-trioxolane antimalarial, and its polar metabolites in rat plasma using hydrophilic interaction chromatography
7. Discovery and Structure–Activity Relationships of Quinazolinone-2-carboxamide Derivatives as Novel Orally Efficacious Antimalarials
8. Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439
9. MOESM1 of An in vitro toolbox to accelerate anti-malarial drug discovery and development
10. Identification and quantification of antioxidants in Fructus lycii
11. Identification of an antimalarial synthetic trioxolane drug development candidate
12. Metabolic, Pharmacokinetic, and Activity Profile of the Liver Stage Antimalarial (RC-12).
13. Sensitive method for the quantitative determination of proguanil and its metabolites in rat blood and plasma by liquid chromatography–mass spectrometry
14. Observation of amide anions in solution by electrospray ionization mass spectrometry
15. Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria
16. Structure–Activity Relationship of Antischistosomal Ozonide Carboxylic Acids
17. CpG methylation potentiates pixantrone and doxorubicin-induced DNA damage and is a marker of drug sensitivity
18. Comment on: Development and validation of a reversed-phase high-performance liquid chromatography assay for polymyxin B in human plasma
19. Mechanistic Investigation of the Reduction in Antimicrobial Activity of Ciprofloxacin by Metal Cations
20. Genistein- and daidzein 7-O-β-D-glucuronic acid retain the ability to inhibit copper-mediated lipid oxidation of low density lipoprotein
21. Development and validation of a reversed-phase high-performance liquid chromatography assay for polymyxin B in human plasma
22. Triazolines 34. Structure and Stability Relationships of Novel Δ2-l,2,3-Triazoline Anticonvulsants
23. Manufacturing cell operating characteristics
24. Potential Diagnostic Imaging of Alzheimer’s Disease with Copper-64 Complexes That Bind to Amyloid-β Plaques
25. 3,3′-Disubstituted 5,5′-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity
26. A Longitudinal Study on the Prevalence and Risk Factors for Depression and Anxiety, Quality of Life, and Clinical Outcomes in Incident Peritoneal Dialysis Patients
27. Morphiceptin analogs as ligands for the putative ϵ opioid receptor
28. Inhibitors of HIV protease based on modified peptide substrates
29. The effect of yeast elicitor on the growth and secondary metabolism of hairy root cultures of Salvia miltiorrhiza
30. Pre-column derivatization and gas chromatographic determination of alkaloids in bulbs of Fritillaria
31. Structure–Activity Relationship of the Antimalarial Ozonide Artefenomel (OZ439)
32. The Prognostic Value of Admission AVPU and Glasgow Coma Scales in Acute Drug Poisoning Patients.
33. Structure–Activity Relationship of Antischistosomal Ozonide Carboxylic Acids
34. Revisiting the SAR of the Antischistosomal Aryl Hydantoin (Ro 13-3978)
35. A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria
36. Understanding Oxadiazolothiazinone Biological Properties: Negative Inotropic Activity versus Cytochrome P450-Mediated Metabolism
37. Evidence for the in Vitro Bioactivation of Aminopyrazole Derivatives: Trapping Reactive Aminopyrazole Intermediates Using Glutathione Ethyl Ester in Human Liver Microsomes
38. Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins
39. Structure-Activity Relationship of the Antimalarial Ozonide Artefenomel (OZ439).
40. Revisiting the SAR of the Antischistosomal Aryl Hydantoin (Ro 13-3978).
41. The comparative antimalarial properties of weak base and neutral synthetic ozonides
42. Two Analogues of Fenarimol Show Curative Activity in an Experimental Model of Chagas Disease
43. Synthesis and biological evaluation of polysulfated oligosaccharide glycosides as inhibitors of angiogenesis and tumor growth
44. Comparative Antimalarial Activities and ADME Profiles of Ozonides (1,2,4-trioxolanes) OZ277, OZ439, and Their 1,2-Dioxolane, 1,2,4-Trioxane, and 1,2,4,5-Tetraoxane Isosteres
45. Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins.
46. Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277
47. The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson’s disease
48. Design, synthesis, and evaluation of a new fluorescent probe for measuring polymyxin–lipopolysaccharide binding interactions
49. Synthesis and Biological Evaluation of Polysulfated Oligosaccharide Glycosides as Inhibitors of Angiogenesis and Tumor Growth
50. Stability of Peroxide Antimalarials in the Presence of Human Hemoglobin
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