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The stability of Electro Phoretic Deposition (EPD) suspensions containing nanoparticles relies on the impact of Zeta Potential (ZP or ). This property ensures that the nanoparticles have a consistent and stable surface charge, resulting in a uniform and stable coating. This research has been conducted as an experimental study and used the Taguchi method to design experiment optimization of the Zeta potential values, which were obtained by preparing nine suspensions. The study aimed to determine the optimal ZP value for the EPD suspension created with three materials mixed: nanochitason, Chitason/SrCl2/MgO, and a constant value of hydroxyapatite (HA) with consideration of the pH effect. After conducting an analysis, it was found that the suspension's Zeta Potential is negatively charged below a pH value of 8.22. Between 8.22 and 9.7, the ZP has a positive charge. The suspension's isoelectric point (IEP) is 8.22, with a high correlation coefficient indicating the model's reliability in predicting responses. The analysis showed that SrCl2 has the most significant impact on the suspension's ZP, followed by Chitason (CH), with MgO having the least impact. The results demonstrate the effectiveness of this analysis in determining the optimum ZP value for various solutions prepared from different biomaterial particles

The aim of this work was to develop a bioactive glass/hydroxylapatite/chitason composite material for bone repair. Different proportions of bioactive glass/hydroxylapatite/chitason mixture was make into scaffolds by the freeze-drying method. The microstructure and composition were observed and analysed. The third-generation rabbit mesenchymal stem cells were inoculated into the stent. The adhesion of the stent was detected, and the proliferation of cells on the stent was detected. The compatibility between the stent and cells was evaluated. The size and shapes of the prepared bioactive glass/hydroxylapatite/chitason stent were consistent with moulds. The stent has parous structure and no aggregation of bioactive glass was found. The rabbit mesenchymal stem adhered to the stent, and some cells extended and stretched out pseudopodia. Obvious proliferation of bone marrow stromal cells was found on the stent. The prepared bioactive glass/hydroxylapatite/chitason stents have good porosity, high mechanical strength, and good cell compatibility. [ABSTRACT FROM AUTHOR]