17 results on '"Chisato Kodera"'
Search Results
2. Progressive idiopathic juvenile osteoporosis in pregnancy: A case report of two successive pregnancies in the same woman
- Author
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Kaori Kishimoto, Chisato Kodera, Fumitaka Saito, Takashi Ohba, and Hidetaka Katabuchi
- Subjects
Juvenile osteoporosis ,Bisphosphonate ,Osteoporosis ,Lactation ,Pregnancy ,Delivery ,Surgery ,RD1-811 ,Gynecology and obstetrics ,RG1-991 - Abstract
A 33-year-old primiparous woman with progressive idiopathic juvenile osteoporosis (IJO) who had had multiple vertebral compressions and bilateral femoral neck fractures since the age of 15 years presented for perinatal management at 11 weeks of gestation. Her vertebral bone mass was 0.634 g/cm2 before pregnancy. The target calcium intake was set at 800 mg/day. Cephalopelvic disproportion led to the patient having an elective cesarean section at 39 weeks 3 days of gestation and she delivered a female infant weighing 2785 g. After the delivery, her vertebral bone mass had increased to 0.700 g/cm2. At 34 years of age, she conceived her second child. With similar perinatal management, she delivered a female infant weighing 2580 g at 38 weeks of gestation by elective cesarean section. Her vertebral bone mass had increased again after the second pregnancy. Few cases of pregnancy complicated by progressive IJO have been reported. However, an uneventful pregnancy course can be expected with proper management, and pregnancy can be a good opportunity to increase bone mass.
- Published
- 2021
- Full Text
- View/download PDF
3. KCTD19 and its associated protein ZFP541 are independently essential for meiosis in male mice.
- Author
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Seiya Oura, Takayuki Koyano, Chisato Kodera, Yuki Horisawa-Takada, Makoto Matsuyama, Kei-Ichiro Ishiguro, and Masahito Ikawa
- Subjects
Genetics ,QH426-470 - Abstract
Meiosis is a cell division process with complex chromosome events where various molecules must work in tandem. To find meiosis-related genes, we screened evolutionarily conserved and reproductive tract-enriched genes using the CRISPR/Cas9 system and identified potassium channel tetramerization domain containing 19 (Kctd19) as an essential factor for meiosis. In prophase I, Kctd19 deficiency did not affect synapsis or the DNA damage response, and chiasma structures were also observed in metaphase I spermatocytes of Kctd19 KO mice. However, spermatocytes underwent apoptotic elimination during the metaphase-anaphase transition. We were able to rescue the Kctd19 KO phenotype with an epitope-tagged Kctd19 transgene. By immunoprecipitation-mass spectrometry, we confirmed the association of KCTD19 with zinc finger protein 541 (ZFP541) and histone deacetylase 1 (HDAC1). Phenotyping of Zfp541 KO spermatocytes demonstrated XY chromosome asynapsis and recurrent DNA damage in the late pachytene stage, leading to apoptosis. In summary, our study reveals that KCTD19 associates with ZFP541 and HDAC1, and that both KCTD19 and ZFP541 are essential for meiosis in male mice.
- Published
- 2021
- Full Text
- View/download PDF
4. Sac-Type Congenital Diaphragmatic Hernia: A Case Report of Two Siblings
- Author
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Chisato Kodera, Takashi Ohba, Tomomi Hashimoto, Munekage Yamaguchi, Hidetaka Yoshimatsu, and Hidetaka Katabuchi
- Subjects
Gynecology and obstetrics ,RG1-991 - Abstract
Congenital diaphragmatic hernia (CDH), a herniation of the abdominal contents through a defect or hypoplasia of the diaphragm, is a relatively common, severe congenital anomaly. Here we present the first case of two siblings with possibly isolated sac-type CDH and with a suspected genetic etiology. Although sibling recurrence of isolated CDH is rare, the incidence is higher than in the general population. Additionally, the second child had a more severe respiratory disorder than the first child. It is to be noted that siblings of children having isolated CDH are at risk for CDH, and prenatal evaluation should be considered individually.
- Published
- 2018
- Full Text
- View/download PDF
5. 'Welcome to <scp>OBGYN</scp> World!' A novel recruitment event for medical students organized by the Japan Society of Obstetrics and Gynecology
- Author
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Ryuta Miyake, Hiroaki Komatsu, Kei Ihira, Akihiro Hasegawa, Yuto Maeda, Satoshi Takemori, Masashi Noguchi, Mihoko Dofutsu, Yohei Onodera, Manaka Shinagawa, Tokumasa Suemitsu, Yosuke Sugita, Yayoi Higuchi, Nanae Izaki, Chisato Kodera, Yoshikazu Nagase, Kei Odawara, Junpei Ogura, Daiken Osaku, Takuma Ohsuga, Naosuke Enomoto, Takahiro Kanai, Sakurako Mishima, Keiko Morita, Satoyo Otsuka, Kensuke Suzuki, Kiyonori Miura, and Yoshio Yoshida
- Subjects
Obstetrics and Gynecology - Abstract
"Welcome to OBGYN World!" A novel recruitment event for medical students organized by the Japan Society of Obstetrics and Gynecology. Since 2012, the number of doctors in Japan who specialize in obstetrics and gynecology has shown a decreasing trend. To increase the number of doctors majoring in obstetrics and gynecology, the Japanese Trainees in Obstetrics and Gynecology subcommittee developed a new recruitment event called Welcome to OBGYN World! (WOW!); the aim of this event was to focus on lower grades of medical students. The present report describes the content of WOW! and the results of a post-event questionnaire administered to participating students and tutors. WOW! was held online in order to avoid the risk of Coronavirus Disease 2019 infection for participants. Sixty of the 82 medical schools nationwide (73.2%) participated in this event. Overall, there were 285 participating students, ranging from first to fourth grade in medical school, and 106 tutors were involved to teach material at the event. In the post-event questionnaire survey, 97.6% (248/254) and 100% of the participants stated they now had a high degree of interest in obstetrics and gynecology and found the specialty attractive, respectively. Furthermore, 93.6% (90/94) of the tutors stated that WOW! had helped recruitment activities in their universities. Based on this outcome, members of the Japanese Trainees of Obstetrics and Gynecology subcommittee will now try to increase the number of doctors specializing in obstetrics and gynecology by holding WOW! annually.
- Published
- 2022
6. Perinatal manifestation of pseudohypoaldosteronism type 2 in a mother and her children
- Author
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Takashige Kuwabara, Chisato Kodera, Takashi Ohba, and Hidetaka Katabuchi
- Subjects
Pediatrics ,medicine.medical_specialty ,business.industry ,Medicine ,Pseudohypoaldosteronism Type 2 ,business - Published
- 2021
7. Attitudes toward overtime work and self‐training: A survey on obstetricians and gynecologists in Japan
- Author
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Michinori Mayama, Chisato Kodera, Takayuki Enomoto, Michiko Kido, Tokumasa Suemitsu, Takuma Ohsuga, Masayuki Sekine, Yosuke Sugita, Takeshi Umazume, Kazutoshi Nakano, Yuto Maeda, Satoshi Nakagawa, Koji Nishijima, Takashi Murakami, Hidemichi Watari, Yukio Suzuki, Ayako Shibata, Makio Shozu, Nobuya Unno, Yohei Onodera, Jumpei Ogura, and Hiroaki Komatsu
- Subjects
Generation gap ,medicine.medical_specialty ,business.industry ,media_common.quotation_subject ,education ,Obstetrics and Gynecology ,Questionnaire ,Overtime work ,Obstetrics ,Attitude ,Japan ,Obstetrics and gynaecology ,Gynecology ,Surveys and Questionnaires ,Family medicine ,Humans ,Medicine ,Christian ministry ,Quality (business) ,business ,Self training ,Welfare ,media_common - Abstract
Aim The Ministry of Health, Labour, and Welfare of Japan proposed a regulation of overtime work as a reform in work style. However, the regulation may deteriorate the quality of medical services due to the reduction in training time. Thus, the study aimed to reveal perceptions in terms of generation gaps in views on self-training and overtime work, among members of the Japan Society of Obstetrics and Gynecology (JSOG). Methods A web-based, self-administered questionnaire survey was conducted among members of the JSOG. In total, 1256 respondents were included in the analysis. Data were collected on age, sex, experience as a medical doctor, location of workplace, work style, the type of main workplace, and number of full-time doctors in the main workplace. The study examined the attitudes of the respondents toward overtime work and self-training. The respondents were categorized based on experience as a medical doctor. Results According to years of experience, 112 (8.9%), 226 (18.0%), 383 (30.5%), 535 (42.6%) doctors have been working for ≤5, 6-10, 11-19, and ≥ 20 years, respectively. Although 54.5% of doctors with ≤5 years of experience expected the regulation on working hours to improve the quality of medical services, those with ≥20 years of experience expressed potential deterioration. After adjusting for covariates, more years of experience were significantly related with the expectation of deterioration in the quality of medical services. Conclusions The study revealed a generation gap in the views about self-training and overtime work among obstetricians and gynecologists in Japan.
- Published
- 2021
8. Clinical manifestations of placental mesenchymal dysplasia in Japan: A multicenter case series
- Author
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Takashi Ohba, Masaharu Fukunaga, Yoshiki Mikami, Hidetaka Katabuchi, Ken Higashimoto, Hidenobu Soejima, Chisato Kodera, and Saori Aoki
- Subjects
medicine.medical_specialty ,Fetus ,Pregnancy ,Placenta Diseases ,Cesarean Section ,business.industry ,Obstetrics ,Placenta ,Mortality rate ,Infant, Newborn ,Pregnancy Outcome ,Obstetrics and Gynecology ,medicine.disease ,Placental Mesenchymal Dysplasia ,Human chorionic gonadotropin ,Japan ,Obstetrics and gynaecology ,Humans ,Medicine ,Female ,Fetal Demise ,Child ,business ,Adverse effect - Abstract
Aim This study aimed to evaluate the clinical features and pregnancy outcomes of placental mesenchymal dysplasia (PMD) in Japan. Methods We requested detailed clinical information and placental tissue of PMD cases in 2000-2018 from Japanese facilities with departments of obstetrics and gynecology and analyzed the pregnancy course and neonatal outcomes. Results We collected 49 cases of PMD. Of 18 patients with measured maternal serum alpha-fetoprotein (MSAFP) levels, 15 (83.3%) had elevated levels. Maternal serum human chorionic gonadotropin (MShCG) levels were transiently elevated in five (17.8%) of 28 patients. Forty-seven patients continued their pregnancies. All pregnancies were singleton and 40 (85.1%) were associated with adverse events including fetal growth restriction (FGR), threatened premature delivery, fetal demise, and hypertensive disorder of pregnancy in 34 (72.3%), 14 (29.8%), eight (17.0%), and six (12.8%) patients, respectively. Of 47 infants, there were eight stillbirths. There were 40 (85.1%) female infants, and eight (17.0%) had Beckwith-Wiedemann syndrome. Of 39 live births, 23 (59.0%) were associated with premature induction of labor or cesarean section for obstetric indications related to FGR. Eighteen (46.2%) neonates had complications. PMD-affected placentas were pathologically heterogeneous in both grossly PMD-affected and non-affected areas. Conclusions Our study included the largest number of PMD cases with detailed clinical information. PMD is a high-risk condition for both the mother and the child. Elevated MSAFP levels with normal MShCG levels indicate PMD. Conventional perinatal management of FGR in Japan might be effective in reducing the fetal mortality rate.
- Published
- 2021
9. Maternal thrombocytopenia due to inflammatory changes in the placenta precedes fetal death associated with COVID-19
- Author
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Akihito Sagara, Munekage Yamaguchi, Saori Yoshimura, Chisato Kodera, Takashi Ohba, and Eiji Kondoh
- Subjects
Reproductive Medicine ,Obstetrics and Gynecology ,Developmental Biology - Published
- 2022
10. Progressive idiopathic juvenile osteoporosis in pregnancy: A case report of two successive pregnancies in the same woman
- Author
-
Takashi Ohba, Hidetaka Katabuchi, Chisato Kodera, Kaori Kishimoto, and Fumitaka Saito
- Subjects
medicine.medical_specialty ,RD1-811 ,medicine.medical_treatment ,Osteoporosis ,Femoral Neck Fractures ,Article ,Pregnancy ,Lactation ,medicine ,Bisphosphonate ,Juvenile osteoporosis ,Obstetrics ,business.industry ,Cephalopelvic disproportion ,Obstetrics and Gynecology ,Gynecology and obstetrics ,medicine.disease ,medicine.anatomical_structure ,RG1-991 ,Gestation ,Surgery ,business ,Delivery - Abstract
A 33-year-old primiparous woman with progressive idiopathic juvenile osteoporosis (IJO) who had had multiple vertebral compressions and bilateral femoral neck fractures since the age of 15 years presented for perinatal management at 11 weeks of gestation. Her vertebral bone mass was 0.634 g/cm2 before pregnancy. The target calcium intake was set at 800 mg/day. Cephalopelvic disproportion led to the patient having an elective cesarean section at 39 weeks 3 days of gestation and she delivered a female infant weighing 2785 g. After the delivery, her vertebral bone mass had increased to 0.700 g/cm2. At 34 years of age, she conceived her second child. With similar perinatal management, she delivered a female infant weighing 2580 g at 38 weeks of gestation by elective cesarean section. Her vertebral bone mass had increased again after the second pregnancy. Few cases of pregnancy complicated by progressive IJO have been reported. However, an uneventful pregnancy course can be expected with proper management, and pregnancy can be a good opportunity to increase bone mass., Highlights • We managed two pregnancies with progressive idiopathic juvenile osteoporosis. • These patients could drive increases in bone volume during pregnancy. • Proper nutritional management can provide a favorable perinatal prognosis.
- Published
- 2021
11. KCTD19 associates with ZFP541 and HDAC1 and is required for meiotic exit in male mice
- Author
-
Seiya Oura, Takayuki Koyano, Yuki Horisawa-Takada, Kei-ichiro Ishiguro, Chisato Kodera, Masahito Ikawa, and Makoto Matsuyama
- Subjects
Chromosome segregation ,Meiosis ,Cell division ,Homologous chromosome ,Synapsis ,Chromosome ,Biology ,Homologous recombination ,Chiasma ,Cell biology - Abstract
Meiosis is a cell division process with complex chromosome events where various molecules must work in tandem. To find meiosis-related genes, we screened evolutionarily conserved and reproductive tract-enriched genes using the CRISPR/Cas9 system and identified potassium channel tetramerization domain containing 19 (Kctd19) as an essential factor for meiosis. In prophase I, Kctd19 deficiency did not affect synapsis or the DNA damage response, and chiasma structures were also observed in metaphase I spermatocytes of Kctd19 KO mice. However, spermatocytes underwent apoptotic elimination during the metaphase-anaphase transition. We were able to rescue the Kctd19 KO phenotype with an epitope-tagged Kctd19 transgene. Immunoprecipitation-mass spectrometry identified zinc finger protein 541 (ZFP541) and histone deacetylase 1 (HDAC1) as binding partners of KCTD19, indicating that KCTD19 is involved in chromatin modification. Phenotyping of Zfp541 KO spermatocytes demonstrated XY chromosome asynapsis and recurrent DNA damage in the late pachytene stage, leading to apoptosis. In summary, our study reveals that KCTD19 associates with ZFP541 and HDAC1, and that both KCTD19 and ZFP541 were essential for meiotic exit in male mice.Author summaryMeiosis is a fundamental process that consisting of one round of genomic DNA replication and two rounds of chromosome segregation producing four haploid cells. To properly distribute their genetic material, cells need to undergo complex chromosome events such as a physical linkage of homologous chromosomes (termed synapsis) and meiotic recombination. The molecules involved in these events have not been fully characterized yet, especially in mammals. Using a CRISPR/Cas9-screening system, we identified the potassium channel tetramerization domain containing 19 (Kctd19) as an essential factor for meiosis in male mice. Further, we identified zinc finger protein 541 (ZFP541) and histone deacetylase 1 (HDAC1) as binding partners of KCTD19. By observing meiosis of Zfp541 knockout germ cells, we found that Zfp541 was also essential for meiotic completion. These results show that the KCTD19/ZFP541 complex plays a critical role and is indispensable for male meiosis and fertility.
- Published
- 2021
12. KCTD19 and its associated protein ZFP541 are independently essential for meiosis in male mice
- Author
-
Chisato Kodera, Kei-ichiro Ishiguro, Takayuki Koyano, Masahito Ikawa, Makoto Matsuyama, Seiya Oura, and Yuki Horisawa-Takada
- Subjects
Male ,Cancer Research ,Cell division ,Chromosomal Proteins, Non-Histone ,Cell Cycle Proteins ,Histone Deacetylase 1 ,Apoptosis ,Immunostaining ,QH426-470 ,Mice ,0302 clinical medicine ,Spermatocytes ,Animal Cells ,Testis ,Medicine and Health Sciences ,Transgenes ,Cell Cycle and Cell Division ,Meiotic Prophase I ,Genetics (clinical) ,Conserved Sequence ,Zinc finger ,Staining ,0303 health sciences ,Genes, Essential ,Cell Death ,Chromosome Biology ,Genetically Modified Organisms ,Synapsis ,Nuclear Proteins ,Seminiferous Tubules ,Spermatids ,Chiasma ,Cell biology ,Precipitation Techniques ,Meiosis ,Phenotype ,Cell Processes ,Engineering and Technology ,Cellular Types ,Anatomy ,Genetic Engineering ,Genital Anatomy ,Research Article ,Biotechnology ,DNA damage ,Bioengineering ,Biology ,Research and Analysis Methods ,Evolution, Molecular ,03 medical and health sciences ,Genetics ,Animals ,Immunoprecipitation ,Molecular Biology ,Metaphase ,Ecology, Evolution, Behavior and Systematics ,030304 developmental biology ,Cell Nucleus ,Genetically Modified Animals ,Reproductive System ,Chromosome ,Biology and Life Sciences ,Cell Biology ,Sperm ,Chromosome Pairing ,Fertility ,Germ Cells ,Specimen Preparation and Treatment ,Pachytene Stage ,CRISPR-Cas Systems ,Anaphase ,030217 neurology & neurosurgery ,DNA Damage ,Transcription Factors - Abstract
Meiosis is a cell division process with complex chromosome events where various molecules must work in tandem. To find meiosis-related genes, we screened evolutionarily conserved and reproductive tract-enriched genes using the CRISPR/Cas9 system and identified potassium channel tetramerization domain containing 19 (Kctd19) as an essential factor for meiosis. In prophase I, Kctd19 deficiency did not affect synapsis or the DNA damage response, and chiasma structures were also observed in metaphase I spermatocytes of Kctd19 KO mice. However, spermatocytes underwent apoptotic elimination during the metaphase-anaphase transition. We were able to rescue the Kctd19 KO phenotype with an epitope-tagged Kctd19 transgene. By immunoprecipitation-mass spectrometry, we confirmed the association of KCTD19 with zinc finger protein 541 (ZFP541) and histone deacetylase 1 (HDAC1). Phenotyping of Zfp541 KO spermatocytes demonstrated XY chromosome asynapsis and recurrent DNA damage in the late pachytene stage, leading to apoptosis. In summary, our study reveals that KCTD19 associates with ZFP541 and HDAC1, and that both KCTD19 and ZFP541 are essential for meiosis in male mice., Author summary Meiosis is a fundamental process that consists of one round of genomic DNA replication and two rounds of chromosome segregation, producing four haploid cells. To properly distribute their genetic material, cells need to undergo complex chromosome events such as a physical linkage of homologous chromosomes (termed synapsis) and meiotic recombination. The molecules involved in these events have not been fully characterized yet, especially in mammals. Using a CRISPR/Cas9-screening system, we identified the potassium channel tetramerization domain containing 19 (Kctd19) as an essential factor for meiosis in male mice. Further, we confirmed the association of KCTD19 with zinc finger protein 541 (ZFP541) and histone deacetylase 1 (HDAC1). By observing meiosis of Zfp541 knockout germ cells, we found that Zfp541 was also essential for meiosis. These results show that the KCTD19/ZFP541 complex plays a critical role and is indispensable for male meiosis and fertility.
- Published
- 2021
13. Meiosis-specific ZFP541 repressor complex promotes meiotic prophase exit during spermatogenesis
- Author
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Kazumasa Takemoto, Chisato Kodera, Sayoko Fujimura, Takashi Ohba, Hitoshi Niwa, Naoki Tani, Kimi Araki, Shingo Usuki, Ryuki Shimada, Akihiko Sakashita, Atsushi Suzuki, Yuki Horisawa-Takada, Kei-ichiro Ishiguro, Makoto Tachibana, Tomohiko Akiyama, Ryo Maeda, Hidetaka Katabuchi, Satoshi H. Namekawa, Kumi Matsuura, and Kenichi Horisawa
- Subjects
Prophase ,Meiosis ,Gene expression ,Transcriptional regulation ,Repressor ,Biology ,Gene ,Covalent chromatin modification ,Cell biology ,Chromatin - Abstract
SummaryDuring spermatogenesis, meiosis is accompanied by robust alteration in gene expression and chromatin status. However, it remained elusive how meiotic transcriptional program is established to ensure completion of meiotic prophase. Here, we identified a novel protein complex consisting of germ-cell-specific zinc-finger protein ZFP541 and its interactor KCTD19 as the key transcriptional regulator for meiotic prophase exit. Our genetic study showed that ZFP541 and KCTD19 are co-expressed from pachytene onward and play an essential role in the completion of meiotic prophase program in the testis. Furthermore, our ChIP-seq and transcriptome analyses revealed that ZFP541 binds to and suppresses a broad range of genes whose function is associated with biological processes of transcriptional regulation and covalent chromatin modification. The present study demonstrated that germ-cell specific ZFP541-KCTD19 containing complex promotes meiotic prophase exit in males, and triggers reconstruction of the transcription network and chromatin organization leading to post-meiotic development.
- Published
- 2021
14. Meiosis-specific ZFP541 repressor complex promotes developmental progression of meiotic prophase towards completion during mouse spermatogenesis
- Author
-
Chisato Kodera, Akihiko Sakashita, Kazumasa Takemoto, Atsushi Suzuki, Ryo Maeda, Satoshi H. Namekawa, Kimi Araki, Takashi Ohba, Shingo Usuki, Naoki Tani, Yuki Horisawa-Takada, Kumi Matsuura, Ryuki Shimada, Kenichi Horisawa, Tomohiko Akiyama, Kei-ichiro Ishiguro, Sayoko Fujimura, Hitoshi Niwa, Hidetaka Katabuchi, and Makoto Tachibana
- Subjects
0301 basic medicine ,Male ,Potassium Channels ,Transcription, Genetic ,Chromosomal Proteins, Non-Histone ,General Physics and Astronomy ,Histone Deacetylase 2 ,Cell Cycle Proteins ,Histone Deacetylase 1 ,Covalent chromatin modification ,Transcriptome ,Mice ,0302 clinical medicine ,Transcriptional regulation ,RNA-Seq ,Mice, Knockout ,Multidisciplinary ,Voltage-Gated ,Nuclear Proteins ,Spermatids ,Chromatin ,Cell biology ,Chromosomal Proteins ,Meiosis ,Potassium Channels, Voltage-Gated ,Chromatin Immunoprecipitation Sequencing ,Stem Cell Research - Nonembryonic - Non-Human ,Female ,Transcription ,Biotechnology ,Science ,Knockout ,1.1 Normal biological development and functioning ,Repressor ,Biology ,General Biochemistry, Genetics and Molecular Biology ,Article ,03 medical and health sciences ,Prophase ,Genetic ,Underpinning research ,Genetics ,Animals ,Humans ,Spermatogenesis ,Gene ,Infertility, Male ,urogenital system ,Animal ,Contraception/Reproduction ,fungi ,Human Genome ,General Chemistry ,Non-Histone ,Stem Cell Research ,Disease Models, Animal ,030104 developmental biology ,Infertility ,Disease Models ,Oocytes ,Pachytene Stage ,030217 neurology & neurosurgery ,Transcription Factors - Abstract
During spermatogenesis, meiosis is accompanied by a robust alteration in gene expression and chromatin status. However, it remains elusive how the meiotic transcriptional program is established to ensure completion of meiotic prophase. Here, we identify a protein complex that consists of germ-cell-specific zinc-finger protein ZFP541 and its interactor KCTD19 as the key transcriptional regulators in mouse meiotic prophase progression. Our genetic study shows that ZFP541 and KCTD19 are co-expressed from pachytene onward and play an essential role in the completion of the meiotic prophase program in the testis. Furthermore, our ChIP-seq and transcriptome analyses identify that ZFP541 binds to and suppresses a broad range of genes whose function is associated with biological processes of transcriptional regulation and covalent chromatin modification. The present study demonstrates that a germ-cell specific complex that contains ZFP541 and KCTD19 promotes the progression of meiotic prophase towards completion in male mice, and triggers the reconstruction of the transcriptional network and chromatin organization leading to post-meiotic development., The authors add to our knowledge of the transcriptional regulation of the meiotic program in mice spermatocytes, showing ZFP541 regulates meiotic prophase and transition to the division phase by being the target for upstream factors MEIOSIN/STRA8.
- Published
- 2021
15. 本邦における間葉性異形成胎盤の臨床像:多施設共同ケースシリーズ
- Author
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Chisato, Kodera
- Subjects
377.5 - Published
- 2020
16. Sac-Type Congenital Diaphragmatic Hernia: A Case Report of Two Siblings
- Author
-
Hidetaka Katabuchi, Hidetaka Yoshimatsu, Chisato Kodera, Tomomi Hashimoto, Takashi Ohba, and Munekage Yamaguchi
- Subjects
0301 basic medicine ,Pediatrics ,medicine.medical_specialty ,education.field_of_study ,business.industry ,Incidence (epidemiology) ,Population ,Obstetrics and Gynecology ,Congenital diaphragmatic hernia ,Case Report ,medicine.disease ,lcsh:Gynecology and obstetrics ,Hypoplasia ,Diaphragm (structural system) ,03 medical and health sciences ,030104 developmental biology ,Genetic etiology ,medicine ,Respiratory system ,Sibling ,business ,education ,lcsh:RG1-991 - Abstract
Congenital diaphragmatic hernia (CDH), a herniation of the abdominal contents through a defect or hypoplasia of the diaphragm, is a relatively common, severe congenital anomaly. Here we present the first case of two siblings with possibly isolated sac-type CDH and with a suspected genetic etiology. Although sibling recurrence of isolated CDH is rare, the incidence is higher than in the general population. Additionally, the second child had a more severe respiratory disorder than the first child. It is to be noted that siblings of children having isolated CDH are at risk for CDH, and prenatal evaluation should be considered individually.
- Published
- 2018
17. Umbilical cord edema with umbilical cord hemangioma in pregnancy, a case report
- Author
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Risa Shimokawa, Chisato Kodera, Hidetaka Katabuchi, Hiroshi Mitubuchi, Tetsuo Naramura, and Takasi Ohaba
- Subjects
Pregnancy ,Pathology ,medicine.medical_specialty ,business.industry ,Obstetrics and Gynecology ,medicine.disease ,Umbilical cord ,medicine.anatomical_structure ,Reproductive Medicine ,Edema ,Medicine ,medicine.symptom ,business ,Umbilical cord hemangioma ,Developmental Biology - Published
- 2019
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