363 results on '"Chioncel, O."'
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2. Socioeconomic variations determine the clinical presentation, aetiology, and outcome of infective endocarditis: a prospective cohort study from the ESC-EORP EURO-ENDO (European Infective Endocarditis) registry
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Sengupta, S, Prendergast, B, Laroche, C, Furnaz, S, Ronderos, R, Almaghraby, A, Asch, F, Blechova, K, Zaky, H, Strahilevitz, J, Dworakowski, R, Miyasaka, Y, Sebag, I, Izumi, C, Axler, O, Jamiel, A, Philip, M, Vieira, M, Lancellotti, P, Habib, G, Gale, C, Beleslin, B, Budaj, A, Chioncel, O, Dagres, N, Danchin, N, Emberson, J, Erlinge, D, Glikson, M, Gray, A, Kayikcioglu, M, Maggioni, A, Nagy, V, Nedoshivin, A, Petronio, A, Roos-Hesselink, J, Wallentin, L, Zeymer, U, Cosyns, B, Donal, E, Erba, P, Iung, B, Popescu, B, Tornos, P, Andarala, M, Berle, C, Brunel-Lebecq, A, Fiorucci, E, Missiamenou, V, Taylor, C, Ali Tatar-Chentir, N, Al-Mallah, M, Astrom Aneq, M, Athanassopoulos, G, Badano, L, Benyoussef, S, Calderon Aranda, E, Cardim, N, Chan, K, Cruz, I, Edvardsen, T, Goliasch, G, Hagendorff, A, Hristova, K, Kamp, O, Kang, D, Kong, W, Matskeplishvili, S, Meshaal, M, Mirocevic, M, Neskovic, A, Pazdernik, M, Plonska-Gosciniak, E, Raissouni, M, Sade, L, Sadeghpour, A, Sambola, A, Separovic-Hanzevacki, J, Takeuchi, M, Tucay, E, Tude Rodrigues, A, Varga, A, Vaskelyte, J, Yamagata, K, Yiangou, K, Granada, I, Mahia, M, Ressi, S, Na-Cinovich, F, Iribarren, A, Fernandez Oses, P, Avegliano, G, Filipini, E, Obregon, R, Bangher, M, Dho, J, Cartasegna, L, Plastino, M, Novas, V, Shigel, C, Reyes, G, De Santos, M, Gastaldello, N, Granillo Fernandez, M, Potito, M, Streit-Enberger, G, Velazco, P, Casabe, J, Cortes, C, Guevara, E, Salmo, F, Seijo, M, Weidinger, F, Heger, M, Brooks, R, Stollberger, C, Ho, C, Perschy, L, Puskas, L, Binder, C, Rosenhek, R, Schneider, M, Winter, M, Hoffer, E, Melis-Sopoulou, M, Lecoq, E, Legrand, D, Jacquet, S, Massoz, M, Pierard, L, Marchetta, S, Dulgheru, R, D'Emal, C, Oury, C, Droog-Mans, S, Kerkhove, D, Plein, D, Soens, L, Weytjens, C, Motoc, A, Roosens, B, Lemoine, I, Rodrigus, I, Paelinck, B, Am-Sel, B, Unger, P, Konopnicki, D, Beauloye, C, Pasquet, A, Vanoverschelde, J, Pierard, S, Vancraeynest, D, Sinnaeve, F, Andrade, J, Staszko, K, Dos Santos Monteiro, R, Miglioranza, M, Shuha, D, Alcantara, M, Cravo, V, Fazzio, L, Felix, A, Iso, M, Musa, C, Siciliano, A, Villaca Filho, F, Rodrigues, A, Vilela, F, Braga, J, Silva, R, Rodrigues, D, Silva, L, Morhy, S, Fischer, C, Afonso, T, Abreu, J, Falcao, S, Moises, V, Gou-Vea, A, Mancuso, F, Souza, A, Silva, C, Joao, G, Abboud, C, Bellio de Mattos Barretto, R, Ramos, A, Arnoni, R, Assef, J, Della Togna, D, Le Bihan, D, Miglioli, L, Romero Oliveira, A, Tadeu Magro Kroll, R, Cortez, D, Gelape, C, Peirira Nunes, M, De Abreu Ferrari, T, Hay, K, Le, V, Page, M, Poulin, F, Sauve, C, Serri, K, Mercure, C, Beaudoin, J, Pibarot, P, Rudski, L, Ricafort, G, Barsic, B, Krajinovic, V, Vargovic, M, Lovric, D, Reskovic-Luksic, V, Vincelj, J, Jaksic Jurinjak, S, Yiannikourides, V, Ioannides, M, Pofaides, C, Masoura, V, Pudich, J, Linhart, A, Siranec, M, Marek, J, Kamenik, M, Pelouch, R, Coufal, Z, Mikulica, M, Griva, M, Jancova, E, Mikulcova, M, Taborsky, M, Precek, J, Jecmenova, M, Latal, J, Widimsky, J, Butta, T, Machacek, S, Vancata, R, Spinar, J, Holicka, M, Pow Chon Long, F, Anzules, N, Bajana Carpio, A, Largacha, G, Penaherrera, E, Moreira, D, Mahfouz, E, Elsafty, E, Soliman, A, Zayed, Y, Aboulenein, J, Abdel-Hay, M, Abdelnaby, M, Ahmed, M, Hammad, B, Saleh, Y, Zahran, H, El-Gebaly, O, Saad, A, Ali, M, Zeid, A, El Sharkawy, R, Al Kholy, A, Doss, R, Osama, D, Rizk, H, Elmogy, A, Mishriky, M, Assayag, P, El Hatimi, S, Hubert, S, Casalta, J, Gouriet, F, Arregle, F, Cammilleri, S, Tessonnier, L, Riberi, A, Botelho-Nevers, E, Gagneux-Brunon, A, Pierrard, R, Tulane, C, Campisi, S, Fuzellier, J, Detoc, M, Mehalla, T, Boutoille, D, Lecompte, A, Lefebvre, M, Pattier, S, Al Habash, O, Asseray-Madani, N, Biron, C, Brochard, J, Caillon, J, Cueff, C, Le Tourneau, T, Lecomte, R, Magali Michel, M, Orain, J, Delarue, S, Le Bras, M, Faucher, J, Aboyans, V, Bee-Harry, A, Durox, H, Lacoste, M, Magne, J, Mohty, D, David, A, Pradel, V, Sierra, V, Neykova, A, Bettayeb, B, Elkentaoui, S, Tzvetkov, B, Landry, G, Strady, C, Ainine, K, Baumard, S, Brasselet, C, Tassigny, C, Valente-Pires, V, Lefranc, M, Hoen, B, Lefevre, B, Curlier, E, Callier, C, Fourcade, N, Jobic, Y, Ansard, S, Le Berre, R, Le Ven, F, Pouliquen, M, Prat, G, Le Roux, P, Bouchart, F, Savoure, A, Alarcon, C, Chapuzet, C, Gueit, I, Tribouilloy, C, Bohbot, Y, Peugnet, F, Gun, M, Duval, X, Lescure, X, Ilic-Habensus, E, Sadoul, N, Selton-Suty, C, Alla, F, Goehringer, F, Huttin, O, Chevalier, E, Garcia, R, Le Marcis, V, Tattevin, P, Flecher, E, Revest, M, Chirouze, C, Bouiller, K, Hustache-Mathieu, L, Klopfenstein, T, Moreau, J, Fournier, D, Brunel, A, Lim, P, Oliver, L, Ternacle, J, Moussafeur, A, Chavanet, P, Piroth, L, Salmon-Rousseau, A, Buisson, M, Mahy, S, Martins, C, Go-Hier, S, Baumann, F, Lebras, S, Piper, C, Guckel, D, Borgermann, J, Horstkotte, D, Winkelmann, E, Brockmeier, B, Grey, D, Nick-Enig, G, Schueler, R, Ozturk, C, Stohr, E, Hamm, C, Walther, T, Brandt, R, Fruhauf, A, Hartung, C, Hellner, C, Wild, C, Becker, M, Hamada, S, Kaestner, W, Stangl, K, Knebel, F, Baldenhofer, G, Brecht, A, Dreger, H, Isner, C, Pfafflin, F, Stegemann, M, Zahn, R, Fraiture, B, Kilkowski, C, Karcher, A, Klinger, S, Tolksdorf, H, Tousoulis, D, Aggeli, C, Sideris, S, Venieri, E, Sarri, G, Tsiapras, D, Armenis, I, Koutsiari, A, Floros, G, Grassos, C, Dragasis, S, Rallidis, L, Varlamos, C, Michalis, L, Naka, K, Bechlioulis, A, Kotsia, A, Lakkas, L, Pappas, K, Papadopoulos, C, Kiokas, S, Lioni, A, Misailidou, S, Bar-Betseas, J, Bonou, M, Kapelios, C, Tomprou, I, Zerva, K, Manolis, A, Hamodraka, E, Athanasiou, D, Haralambidis, G, Samaras, H, Poulimenos, L, Nagy, A, Bartykowszki, A, Gara, E, Mungulmare, K, Kasliwal, R, Bansal, M, Ranjan, S, Bhan, A, Kyavar, M, Maleki, M, Noohi Bezanjani, F, Alizadehasl, A, Boudagh, S, Ghavidel, A, Morad-Nejad, P, Pasha, H, Ghadrdoost, B, Gilon, D, Wanounou, M, Israel, S, D'Agostino, C, Colonna, P, De Michele, L, Fumarola, F, Stante, M, Mar-Chionni, N, Scheggi, V, Alterini, B, Del Pace, S, Stefano, P, Sparano, C, Ruozi, N, Tenaglia, R, Muraru, D, Limbruno, U, Cresti, A, Baratta, P, Solari, M, Giannattasio, C, Moreo, A, De Chiara, B, Lopez Montero, B, Musca, F, Orcese, C, Panzeri, F, Spano, F, Russo, C, Alferi, O, De Bonis, M, Chiappetta, S, Del Forno, B, Ripa, M, Scarpellini, P, Tassan Din, C, Castiglioni, B, Pasci-Uta, R, Carletti, S, Ferrara, D, Guffanti, M, Iaci, G, Lapenna, E, Nisi, T, Oltolini, C, Busnardo, E, Pajoro, U, Agricola, E, Meneghin, R, Schiavi, D, Piscione, F, Citro, R, Benvenga, R, Greco, L, Soriente, L, Radano, I, Prota, C, Bellino, M, Di Vece, D, Santini, F, Salsano, A, Olivieri, G, Turrini, F, Messora, R, Tondi, S, Olaru, A, Agnoletto, V, Grassi, L, Leonardi, C, Sansoni, S, Del Ponte, S, Actis Dato, G, De Martino, A, Ohte, N, Kikuchi, S, Wakami, K, Aonuma, K, Seo, Y, Ishizu, T, Machino-Ohtsuka, T, Yamamoto, M, Iida, N, Nakajima, H, Nakagawa, Y, Amano, M, Miyake, M, Takahashi, K, Shiojima, I, Maeba, H, Suwa, Y, Taniguchi, N, Tsujimoto, S, Kitai, T, Ota, M, Yuda, S, Sasaki, S, Hagiwara, N, Yamazaki, K, Ashihara, K, Arai, K, Saitou, C, Saitou, S, Suzuki, G, Shibata, Y, Watanabe, N, Nishino, S, Ashikaga, K, Kuriyama, N, Mahara, K, Okubo, T, Fujimaki, H, Shi-Tan, H, Yamamoto, H, Abe, K, Terada, M, Takanashi, S, Sata, M, Yamada, H, Kusunose, K, Saijo, Y, Seno, H, Yuichiro, O, Onishi, T, Sera, F, Nakatani, S, Mizuno, H, Sengoku, K, Park, S, Eun Kyoung, K, Ga Yeon, L, Hwang, J, Jin-Oh, C, Sang-Chol, L, Sung-A, C, Jang, S, Heo, R, Lee, S, Song, J, Jung, E, Plisiene, J, Dambrauskaite, A, Gruodyte, G, Jonkaitiene, R, Mizariene, V, Atkocaityte, J, Zvirblyte, R, Sow, R, Codreanu, A, Staub, T, Michaux, C, De la Vega, E, Jacobs-Orazi, L, Mallia Azzopardi, C, Xuereb, R, Pis-Copo, T, Farrugia, J, Fenech, M, Pllaha, E, Vella, C, Borg, D, Casha, R, Grib, L, Raevschi, E, Gre-Jdieru, A, Kravcenco, D, Prisacari, E, Samohvalov, E, Samohvalov, S, Sceglova, N, Panfle, E, Cardaniuc, L, Corcea, V, Feodorovici, A, Gaina, V, Girbu, L, Jimbei, P, Balan, G, Cardaniuc, I, Benesco, I, Marian, V, Sumarga, N, Bozovic, B, Bulatovic, N, Lakovic, P, Music, L, Budde, R, Waha-Dat, A, Gamela, T, Meijers, T, Van Melle, J, Deursen, V, Crijns, H, Bekkers, S, Cheriex, E, Gilbers, M, Kietselaer, B, Knackstedt, C, Lorusso, R, Schalla, S, Streukens, S, Chamuleau, S, Cramer, M, Teske, A, Van der Spoel, T, Wind, A, Lokhorst, J, Liesbek, O, Van Heusden, H, Tanis, W, Van der Bilt, I, Vriend, J, De Lange-Van Bruggen, H, Karijodikoro, E, Riezebos, R, van Dongen, E, Schoep, J, Stolk, V, Offstad, J, Beitnes, J, Helle-Valle, T, Skulstad, H, Skardal, R, Qamar, N, Ahmed, B, Butt, M, Khanzada, M, Saghir, T, Wahid, A, Hryniewiecki, T, Szymanski, P, Marzec, K, Misztal-Ogonowska, M, Kosmala, W, Przewlocka-Kosmala, M, Rojek, A, Woznicka, K, Zachwyc, J, Lisowska, A, Kamin-Ska, M, Kasprzak, J, Kowalczyk, E, Strzecka, D, Wejner-Mik, P, Trabulo, M, Freitas, P, Ranchordas, S, Rodrigues, G, Pinto, P, Queiros, C, Azevedo, J, Marques, L, Seabra, D, Branco, L, Cruz, M, Galrinho, A, Moreira, R, Rio, P, Timoteo, A, Selas, M, Carmelo, V, Duque Neves, B, Pereira, H, Guerra, A, Marques, A, Pintassilgo, I, Tomescu, M, Trofenciuc, N, Andor, M, Bordejevic, A, Branea, H, Caruntu, F, Velcean, L, Mavrea, A, Onel, M, Parvanescu, T, Pop, D, Pop-Moldovan, A, Puticiu, M, Cirin, L, Citu, I, Cotoraci, C, Darabantiu, D, Farcas, R, Marincu, I, Ionac, A, Cozma, D, Mornos, C, Goanta, F, Popescu, I, Beyer, R, Mada, R, Rancea, R, Tomoaia, R, Rosianu, H, Stanescu, C, Kobalava, Z, Karaulova, J, Ko-Tova, E, Milto, A, Pisaryuk, A, Povalyaev, N, Sorokina, M, Alrahimi, J, Elshiekh, A, Ahmed, A, Attia, N, Putnikovic, B, Dimic, A, Ivanovic, B, Matic, S, Trifunovic, D, Petrovic, J, Kosevic, D, Stojanovic, I, Petrovic, I, Dabic, P, Milojevic, P, Srdanovic, I, Susak, S, Velicki, L, Vulin, A, Kovacevic, M, Redzek, A, Stefanovic, M, Yeo, T, Poh, K, Vi-Lacosta, I, Ferrera, C, Olmos, C, Abd El-Nasser, M, Calvo Iglesias, F, Bianco-Gonzalez, E, Bravo Amaro, M, Lopez-Rodriguez, E, Lugo Adan, J, Germinas, A, Pazos-Lopez, P, Pereira Loureiro, M, Perez, M, Raposeiras-Roubin, S, Rasheed Yas, S, Suarez-Varela, M, Vasallo Vidal, F, Garcia-Dorado, D, Fernandez-Hidalgo, N, Gonzalez-Alujas, T, Lozano, J, Maisterra, O, Pizzi, N, Rios, R, Bayes-Genis, A, Pedro Botet, L, Vallejo, N, Llibre, C, Mateu, L, Nunez, R, Quesada, D, Berastegui, E, Bosch Portell, D, Aboal Vinas, J, Albert Bertran, X, Brugada Tar-Radellas, R, Loma-Osorio Ricon, P, Tiron de Llano, C, Arnau, M, Bel, A, Blanes, M, Osa, A, Anguita, M, Carrasco, F, Castillo, J, Zamorano, J, Moya Mur, J, Alvaro, M, Fernandez-Golfin, C, Monteagudo, J, Navas Elorza, E, Farinas Alvarez, M, Aguero Balbin, J, Zarauza, J, Gutierrez-Diez, J, Arminanzas, C, Arnaiz de las Revillas, F, Arnaiz Garcia, A, Cobo Belaustegui, M, Fernandez Sampedro, M, Gutierrez Cuadra, M, Garcia Cuello, L, Gonzalez Rico, C, Rodriguez-Alvarez, R, Goikoetxea, J, Montejo, M, Miro, J, Almela, M, Ambrosioni, J, Moreno, A, Quintana, E, Sandoval, E, Tellez, A, Tolosana, J, Vidal, B, Falces, C, Fuster, D, Garcia-De-la-Maria, C, Hernandez-Meneses, M, Llopis, J, Marco, F, Ruiz-Zamora, I, Bardaji Ruiz, A, Sanz Girgas, E, Garcia-Pardo, G, Guillen Marzo, M, Rodriguez Oviedo, A, Villares Jimenez, A, Abid, L, Ham-Mami, R, Kammoun, S, Mourali, M, Mghaieth Zghal, F, Ben Hlima, M, Boudiche, S, Ouali, S, Zakhama, L, Antit, S, Slama, I, Gulel, O, Sahin, M, Karacaglar, E, Kucukoglu, S, Cetinarslan, O, Sinan, U, Canpolat, U, Mutlu, B, Atas, H, Dervishova, R, Ileri, C, Alhashmi, J, Tahir, J, Zarger, P, Baslib, F, Woldman, S, Menezes, L, Primus, C, Uppal, R, Bvekerwa, I, Chandrasekaran, B, Kopanska, A, Chambers, J, Hancock, J, Klein, J, Rajani, R, Ursi, M, Cannata, S, Fife, A, Breeze, J, Browne-Morgan, M, Gunning, M, Streather, S, Zemedkun, M, Alyavi, B, Uzokov, J, Sengupta S. P., Prendergast B., Laroche C., Furnaz S., Ronderos R., Almaghraby A., Asch F. M., Blechova K., Zaky H., Strahilevitz J., Dworakowski R., Miyasaka Y., Sebag I., Izumi C., Axler O., Jamiel A., Philip M., Vieira M. L. C., Lancellotti P., Habib G., Gale C. P., Beleslin B., Budaj A., Chioncel O., Dagres N., Danchin N., Emberson J., Erlinge D., Glikson M., Gray A., Kayikcioglu M., Maggioni A. P., Nagy V. K., Nedoshivin A., Petronio A. -S., Roos-Hesselink J., Wallentin L., Zeymer U., Cosyns B., Donal E., Erba P., Iung B., Popescu B. A., Tornos P., Andarala M., Berle C., Brunel-Lebecq A., Fiorucci E., Missiamenou V., Taylor C., Ali Tatar-Chentir N. N., Al-Mallah M., Astrom Aneq M., Athanassopoulos G., Badano L. P., Benyoussef S., Calderon Aranda E., Cardim N. M., Chan K. -L., Cruz I., Edvardsen T., Goliasch G., Hagendorff A., Hristova K., Kamp O., Kang D. -H., Kong W., Matskeplishvili S., Meshaal M., Mirocevic M., Neskovic A. N., Pazdernik M., Plonska-Gosciniak E., Raissouni M., Sade L. E., Sadeghpour A., Sambola A., Separovic-Hanzevacki J., Takeuchi M., Tucay E., Tude Rodrigues A. C., Varga A., Vaskelyte J., Yamagata K., Yiangou K., Granada I., Mahia M., Ressi S., Na-Cinovich F., Iribarren A., Fernandez Oses P., Avegliano G., Filipini E., Obregon R., Bangher M., Dho J., Cartasegna L., Plastino M. L., Novas V., Shigel C., Reyes G., De Santos M., Gastaldello N., Granillo Fernandez M., Potito M., Streit-Enberger G., Velazco P., Casabe J. H., Cortes C., Guevara E., Salmo F., Seijo M., Weidinger F., Heger M., Brooks R., Stollberger C., Ho C. -Y., Perschy L., Puskas L., Binder C., Rosenhek R., Schneider M., Winter M. -P., Hoffer E., Melis-Sopoulou M., Lecoq E., Legrand D., Jacquet S., Massoz M., Pierard L., Marchetta S., Dulgheru R., D'Emal C., Oury C., Droog-Mans S., Kerkhove D., Plein D., Soens L., Weytjens C., Motoc A., Roosens B., Lemoine I., Rodrigus I., Paelinck B., Am-Sel B., Unger P., Konopnicki D., Beauloye C., Pasquet A., Vanoverschelde J. L., Pierard S., Vancraeynest D., Sinnaeve F., Andrade J. L., Staszko K., Dos Santos Monteiro R., Miglioranza M. H., Shuha D. L., Alcantara M., Cravo V., Fazzio L., Felix A., Iso M., Musa C., Siciliano A. P., Villaca Filho F., Rodrigues A., Vilela F., Braga J., Silva R., Rodrigues D., Silva L., Morhy S., Fischer C., Afonso T., Abreu J., Falcao S. N., Moises V. A., Gou-Vea A., Mancuso F. J., Souza A. C., Silva C. Y., Joao G., Abboud C. S., Bellio de Mattos Barretto R., Ramos A., Arnoni R., Assef J. E., Della Togna D. J., Le Bihan D., Miglioli L., Romero Oliveira A. P., Tadeu Magro Kroll R., Cortez D., Gelape C. L., Peirira Nunes M. D. C., De Abreu Ferrari T. C., Hay K., Le V., Page M., Poulin F., Sauve C., Serri K., Mercure C., Beaudoin J., Pibarot P., Rudski L. G., Ricafort G., Barsic B., Krajinovic V., Vargovic M., Lovric D., Reskovic-Luksic V., Vincelj J., Jaksic Jurinjak S., Yiannikourides V., Ioannides M., Pofaides C., Masoura V., Pudich J., Linhart A., Siranec M., Marek J., Kamenik M., Pelouch R., Coufal Z., Mikulica M., Griva M., Jancova E., Mikulcova M., Taborsky M., Precek J., Jecmenova M., Latal J., Widimsky J., Butta T., Machacek S., Vancata R., Spinar J., Holicka M., Pow Chon Long F., Anzules N., Bajana Carpio A., Largacha G., Penaherrera E., Moreira D., Mahfouz E., Elsafty E., Soliman A., Zayed Y., Aboulenein J., Abdel-Hay M., Abdelnaby M., Ahmed M., Hammad B., Saleh Y., Zahran H., El-Gebaly O., Saad A., Ali M., Zeid A., El Sharkawy R., Al Kholy A., Doss R., Osama D., Rizk H., Elmogy A., Mishriky M., Assayag P., El Hatimi S., Hubert S., Casalta J. -P., Gouriet F., Arregle F., Cammilleri S., Tessonnier L., Riberi A., Botelho-Nevers E., Gagneux-Brunon A., Pierrard R., Tulane C., Campisi S., Fuzellier J. -F., Detoc M., Mehalla T., Boutoille D., Lecompte A. S., Lefebvre M., Pattier S., Al Habash O., Asseray-Madani N., Biron C., Brochard J., Caillon J., Cueff C., Le Tourneau T., Lecomte R., Magali Michel M. M., Orain J., Delarue S., Le Bras M., Faucher J. -F., Aboyans V., Bee-Harry A., Durox H., Lacoste M., Magne J., Mohty D., David A., Pradel V., Sierra V., Neykova A., Bettayeb B., Elkentaoui S., Tzvetkov B., Landry G., Strady C., Ainine K., Baumard S., Brasselet C., Tassigny C., Valente-Pires V., Lefranc M., Hoen B., Lefevre B., Curlier E., Callier C., Fourcade N., Jobic Y., Ansard S., Le Berre R., Le Ven F., Pouliquen M. -C., Prat G., Le Roux P., Bouchart F., Savoure A., Alarcon C., Chapuzet C., Gueit I., Tribouilloy C., Bohbot Y., Peugnet F., Gun M., Duval X., Lescure X., Ilic-Habensus E., Sadoul N., Selton-Suty C., Alla F., Goehringer F., Huttin O., Chevalier E., Garcia R., Le Marcis V., Tattevin P., Flecher E., Revest M., Chirouze C., Bouiller K., Hustache-Mathieu L., Klopfenstein T., Moreau J., Fournier D., Brunel A. -S., Lim P., Oliver L., Ternacle J., Moussafeur A., Chavanet P., Piroth L., Salmon-Rousseau A., Buisson M., Mahy S., Martins C., Go-Hier S., Baumann F., Lebras S., Piper C., Guckel D., Borgermann J., Horstkotte D., Winkelmann E., Brockmeier B., Grey D., Nick-Enig G., Schueler R., Ozturk C., Stohr E., Hamm C., Walther T., Brandt R., Fruhauf A. -C., Hartung C. T., Hellner C., Wild C., Becker M., Hamada S., Kaestner W., Stangl K., Knebel F., Baldenhofer G., Brecht A., Dreger H., Isner C., Pfafflin F., Stegemann M., Zahn R., Fraiture B., Kilkowski C., Karcher A. -K., Klinger S., Tolksdorf H., Tousoulis D., Aggeli C., Sideris S., Venieri E., Sarri G., Tsiapras D., Armenis I., Koutsiari A., Floros G., Grassos C., Dragasis S., Rallidis L., Varlamos C., Michalis L., Naka K., Bechlioulis A., Kotsia A., Lakkas L., Pappas K., Papadopoulos C., Kiokas S., Lioni A., Misailidou S., Bar-Betseas J., Bonou M., Kapelios C., Tomprou I., Zerva K., Manolis A., Hamodraka E., Athanasiou D., Haralambidis G., Samaras H., Poulimenos L., Nagy A., Bartykowszki A., Gara E., Mungulmare K., Kasliwal R., Bansal M., Ranjan S., Bhan A., Kyavar M., Maleki M., Noohi Bezanjani F., Alizadehasl A., Boudagh S., Ghavidel A., Morad-Nejad P., Pasha H. R., Ghadrdoost B., Gilon D., Wanounou M., Israel S., d'Agostino C., Colonna P., De Michele L., Fumarola F., Stante M., Mar-Chionni N., Scheggi V., Alterini B., Del Pace S., Stefano P., Sparano C., Ruozi N., Tenaglia R., Muraru D., Limbruno U., Cresti A., Baratta P., Solari M., Giannattasio C., Moreo A., De Chiara B., Lopez Montero B., Musca F., Orcese C. A., Panzeri F., Spano F., Russo C. F., Alferi O., De Bonis M., Chiappetta S., Del Forno B., Ripa M., Scarpellini P., Tassan Din C., Castiglioni B., Pasci-Uta R., Carletti S., Ferrara D., Guffanti M., Iaci G., Lapenna E., Nisi T., Oltolini C., Busnardo E., Pajoro U., Agricola E., Meneghin R., Schiavi D., Piscione F., Citro R., Benvenga R. M., Greco L., Soriente L., Radano I., Prota C., Bellino M., Di Vece D., Santini F., Salsano A., Olivieri G. M., Turrini F., Messora R., Tondi S., Olaru A., Agnoletto V., Grassi L., Leonardi C., Sansoni S., Del Ponte S., Actis Dato G. M., De Martino A., Ohte N., Kikuchi S., Wakami K., Aonuma K., Seo Y., Ishizu T., Machino-Ohtsuka T., Yamamoto M., Iida N., Nakajima H., Nakagawa Y., Amano M., Miyake M., Takahashi K., Shiojima I., Maeba H., Suwa Y., Taniguchi N., Tsujimoto S., Kitai T., Ota M., Yuda S., Sasaki S., Hagiwara N., Yamazaki K., Ashihara K., Arai K., Saitou C., Saitou S., Suzuki G., Shibata Y., Watanabe N., Nishino S., Ashikaga K., Kuriyama N., Mahara K., Okubo T., Fujimaki H., Shi-Tan H., Yamamoto H., Abe K., Terada M., Takanashi S., Sata M., Yamada H., Kusunose K., Saijo Y., Seno H., Yuichiro O., Onishi T., Sera F., Nakatani S., Mizuno H., Sengoku K., Park S. W., Eun Kyoung K., Ga Yeon L., Hwang J. -W., Jin-Oh C., Park S. -J., Sang-Chol L., Sung-A C., Jang S. Y., Heo R., Lee S., Song J. -M., Jung E., Plisiene J., Dambrauskaite A., Gruodyte G., Jonkaitiene R., Mizariene V., Atkocaityte J., Zvirblyte R., Sow R., Codreanu A., Staub T., Michaux C., De la Vega E. C. L., Jacobs-Orazi L., Mallia Azzopardi C., Xuereb R. G., Pis-Copo T., Farrugia J., Fenech M., Pllaha E., Vella C., Borg D., Casha R., Grib L., Raevschi E., Gre-Jdieru A., Kravcenco D., Prisacari E., Samohvalov E., Samohvalov S., Sceglova N., Panfle E., Cardaniuc L., Corcea V., Feodorovici A., Gaina V., Girbu L., Jimbei P., Balan G., Cardaniuc I., Benesco I., Marian V., Sumarga N., Bozovic B., Bulatovic N., Lakovic P., Music L., Budde R., Waha-Dat A., Gamela T., Meijers T., Van Melle J. P., Deursen V. M., Crijns H. J., Bekkers S. C., Cheriex E. C., Gilbers M., Kietselaer B. L., Knackstedt C., Lorusso R., Schalla S., Streukens S. A., Chamuleau S., Cramer M. -J., Teske A., Van der Spoel T., Wind A., Lokhorst J., Liesbek O., Van Heusden H., Tanis W., Van der Bilt I., Vriend J., De Lange-Van Bruggen H., Karijodikoro E., Riezebos R., van Dongen E., Schoep J., Stolk V., Offstad J. T., Beitnes J. O., Helle-Valle T., Skulstad H., Skardal R., Qamar N., Ahmed B., Butt M. H., Khanzada M. F., Saghir T., Wahid A., Hryniewiecki T., Szymanski P., Marzec K., Misztal-Ogonowska M., Kosmala W., Przewlocka-Kosmala M., Rojek A., Woznicka K., Zachwyc J., Lisowska A., Kamin-Ska M., Kasprzak J. D., Kowalczyk E., Strzecka D. F., Wejner-Mik P., Trabulo M., Freitas P., Ranchordas S., Rodrigues G., Pinto P., Queiros C., Azevedo J., Marques L., Seabra D., Branco L., Cruz M., Galrinho A., Moreira R., Rio P., Timoteo A. T., Selas M., Carmelo V., Duque Neves B., Pereira H., Guerra A., Marques A., Pintassilgo I., Tomescu M. C., Trofenciuc N. -M., Andor M., Bordejevic A., Branea H. S., Caruntu F., Velcean L. A., Mavrea A., Onel M. F., Parvanescu T., Pop D., Pop-Moldovan A. L., Puticiu M. I., Cirin L., Citu I. M., Cotoraci C. A., Darabantiu D., Farcas R., Marincu I., Ionac A., Cozma D., Mornos C., Goanta F., Popescu I., Beyer R., Mada R., Rancea R., Tomoaia R., Rosianu H., Stanescu C., Kobalava Z., Karaulova J., Ko-Tova E., Milto A., Pisaryuk A., Povalyaev N., Sorokina M., Alrahimi J., Elshiekh A., Ahmed A., Attia N., Putnikovic B., Dimic A., Ivanovic B., Matic S., Trifunovic D., Petrovic J., Kosevic D., Stojanovic I., Petrovic I., Dabic P., Milojevic P., Srdanovic I., Susak S., Velicki L., Vulin A., Kovacevic M., Redzek A., Stefanovic M., Yeo T. C., Kong W. K. F., Poh K. K., Vi-Lacosta I., Ferrera C., Olmos C., Abd El-Nasser M., Calvo Iglesias F., Bianco-Gonzalez E., Bravo Amaro M., Lopez-Rodriguez E., Lugo Adan J., Germinas A. N., Pazos-Lopez P., Pereira Loureiro M., Perez M. T., Raposeiras-Roubin S., Rasheed Yas S., Suarez-Varela M. -M., Vasallo Vidal F., Garcia-Dorado D., Fernandez-Hidalgo N., Gonzalez-Alujas T., Lozano J., Maisterra O., Pizzi N., Rios R., Bayes-Genis A., Pedro Botet L., Vallejo N., Llibre C., Mateu L., Nunez R., Quesada D., Berastegui E., Bosch Portell D., Aboal Vinas J., Albert Bertran X., Brugada Tar-Radellas R., Loma-Osorio Ricon P., Tiron de Llano C., Arnau M. A., Bel A., Blanes M., Osa A., Anguita M., Carrasco F., Castillo J. C., Zamorano J. L., Moya Mur J. L., Alvaro M., Fernandez-Golfin C., Monteagudo J. M., Navas Elorza E., Farinas Alvarez M. C., Aguero Balbin J., Zarauza J., Gutierrez-Diez J. F., Arminanzas C., Arnaiz de las Revillas F., Arnaiz Garcia A., Cobo Belaustegui M., Fernandez Sampedro M., Gutierrez Cuadra M., Garcia Cuello L., Gonzalez Rico C., Rodriguez-Alvarez R., Goikoetxea J., Montejo M., Miro J. M., Almela M., Ambrosioni J., Moreno A., Quintana E., Sandoval E., Tellez A., Tolosana J. M., Vidal B., Falces C., Fuster D., Garcia-De-la-Maria C., Hernandez-Meneses M., Llopis J., Marco F., Ruiz-Zamora I., Bardaji Ruiz A., Sanz Girgas E., Garcia-Pardo G., Guillen Marzo M., Rodriguez Oviedo A., Villares Jimenez A., Abid L., Ham-Mami R., Kammoun S., Mourali M. S., Mghaieth Zghal F., Ben Hlima M., Boudiche S., Ouali S., Zakhama L., Antit S., Slama I., Gulel O., Sahin M., Karacaglar E., Kucukoglu S., Cetinarslan O., Sinan U. Y., Canpolat U., Mutlu B., Atas H., Dervishova R., Ileri C., Alhashmi J., Tahir J., Zarger P., Baslib F., Woldman S., Menezes L., Primus C., Uppal R., Bvekerwa I., Chandrasekaran B., Kopanska A., Chambers J., Hancock J., Klein J., Rajani R., Ursi M. P., Cannata S., Fife A., Breeze J., Browne-Morgan M., Gunning M., Streather S., Zemedkun M., Alyavi B., Uzokov J., Sengupta, S, Prendergast, B, Laroche, C, Furnaz, S, Ronderos, R, Almaghraby, A, Asch, F, Blechova, K, Zaky, H, Strahilevitz, J, Dworakowski, R, Miyasaka, Y, Sebag, I, Izumi, C, Axler, O, Jamiel, A, Philip, M, Vieira, M, Lancellotti, P, Habib, G, Gale, C, Beleslin, B, Budaj, A, Chioncel, O, Dagres, N, Danchin, N, Emberson, J, Erlinge, D, Glikson, M, Gray, A, Kayikcioglu, M, Maggioni, A, Nagy, V, Nedoshivin, A, Petronio, A, Roos-Hesselink, J, Wallentin, L, Zeymer, U, Cosyns, B, Donal, E, Erba, P, Iung, B, Popescu, B, Tornos, P, Andarala, M, Berle, C, Brunel-Lebecq, A, Fiorucci, E, Missiamenou, V, Taylor, C, Ali Tatar-Chentir, N, Al-Mallah, M, Astrom Aneq, M, Athanassopoulos, G, Badano, L, Benyoussef, S, Calderon Aranda, E, Cardim, N, Chan, K, Cruz, I, Edvardsen, T, Goliasch, G, Hagendorff, A, Hristova, K, Kamp, O, Kang, D, Kong, W, Matskeplishvili, S, Meshaal, M, Mirocevic, 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A., Darabantiu D., Farcas R., Marincu I., Ionac A., Cozma D., Mornos C., Goanta F., Popescu I., Beyer R., Mada R., Rancea R., Tomoaia R., Rosianu H., Stanescu C., Kobalava Z., Karaulova J., Ko-Tova E., Milto A., Pisaryuk A., Povalyaev N., Sorokina M., Alrahimi J., Elshiekh A., Ahmed A., Attia N., Putnikovic B., Dimic A., Ivanovic B., Matic S., Trifunovic D., Petrovic J., Kosevic D., Stojanovic I., Petrovic I., Dabic P., Milojevic P., Srdanovic I., Susak S., Velicki L., Vulin A., Kovacevic M., Redzek A., Stefanovic M., Yeo T. C., Kong W. K. F., Poh K. K., Vi-Lacosta I., Ferrera C., Olmos C., Abd El-Nasser M., Calvo Iglesias F., Bianco-Gonzalez E., Bravo Amaro M., Lopez-Rodriguez E., Lugo Adan J., Germinas A. N., Pazos-Lopez P., Pereira Loureiro M., Perez M. 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M., Vidal B., Falces C., Fuster D., Garcia-De-la-Maria C., Hernandez-Meneses M., Llopis J., Marco F., Ruiz-Zamora I., Bardaji Ruiz A., Sanz Girgas E., Garcia-Pardo G., Guillen Marzo M., Rodriguez Oviedo A., Villares Jimenez A., Abid L., Ham-Mami R., Kammoun S., Mourali M. S., Mghaieth Zghal F., Ben Hlima M., Boudiche S., Ouali S., Zakhama L., Antit S., Slama I., Gulel O., Sahin M., Karacaglar E., Kucukoglu S., Cetinarslan O., Sinan U. Y., Canpolat U., Mutlu B., Atas H., Dervishova R., Ileri C., Alhashmi J., Tahir J., Zarger P., Baslib F., Woldman S., Menezes L., Primus C., Uppal R., Bvekerwa I., Chandrasekaran B., Kopanska A., Chambers J., Hancock J., Klein J., Rajani R., Ursi M. P., Cannata S., Fife A., Breeze J., Browne-Morgan M., Gunning M., Streather S., Zemedkun M., Alyavi B., and Uzokov J.
- Abstract
Aims Infective endocarditis (IE) is a life-threatening disease associated with high mortality and morbidity worldwide. We sought to determine how socioeconomic factors might influence its epidemiology, clinical presentation, investigation and management, and outcome, in a large international multicentre registry. Methods and results The EurObservational Programme (EORP) of the European Society of Cardiology EURO-ENDO (European Infective Endocarditis) registry comprises a prospective cohort of 3113 adult patients admitted for IE in 156 hospitals in 40 countries between January 2016 and March 2018. Patients were separated in three groups, according to World Bank economic stratification [group 1: high income (75.6%); group 2: upper-middle income (15.4%); group 3: lower-middle income (9.1%)]. Group 3 patients were younger [median age (interquartile range, IQR): group 1, 66 (53-75) years; group 2, 57 (41-68) years; group 3, 33 (26-43) years; P < 0.001] with a higher frequency of smokers, intravenous drug use, and human immunodeficiency virus infection (all P < 0.001) and presented later [median (IQR) days since symptom onset: group 1, 12 (3-35); group 2, 19 (6-54); group 3, 31 (12-62); P < 0.001] with a higher likelihood of developing congestive heart failure (13.6%, 11.1%, and 22.6%, respectively; P < 0.001) and persistent fever (9.8%, 14.2%, and 27.9%, respectively; P < 0.001). Among 2157 (69.3%) patients with theoretical indication for cardiac surgery, surgery was performed less frequently in group 3 patients (75.5%, 76.8%, and 51.3%, respectively; P < 0.001), who also demonstrated the highest mortality (15.0%, 23.0%, and 23.7%, respectively; P < 0.001). Conclusion Socioeconomic factors influence the clinical profile of patients presenting with IE across the world. Despite younger age, patients from the poorest countries presented with more frequent complications and higher mortality associated with delayed diagnosis and lower use of surgery.
- Published
- 2023
3. Performance of Prognostic Risk Scores in Chronic Heart Failure Patients Enrolled in the European Society of Cardiology Heart Failure Long-Term Registry
- Author
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T., Losic, R., Bombek, M., Krajnc, I., Krunic, B., Horvat, S., Kovac, D., Rajtman, D., Cencic, V., Letonja, M., Winkler, R., Valentincic, M., Melihen-Bartolic, C., Bartolic, A., Pusnik Vrckovnik, M., Kladnik, M., Slemenik Pusnik, C., Marolt, A., Klen, J., Drnovsek, B., Leskovar, B., Fernandez Anguita, M.J., Gallego Page, J.C., Salmeron Martinez, F.M., Andres, J., Genis, A.B., Mirabet, S., Mendez, A., Garcia-Cosio, L., Roig, E., Leon, V., Gonzalez-Costello, J., Muntane, G., Garay, A., Alcade-Martinez, V., Lopez Fernandez, S., Rivera-Lopez, R., Puga-Martinez, M., Fernandez-Alvarez, M., Serrano-Martinez, J.L., Grille-Cancela, Z., Marzoa-Rivas, R., Blanco-Canosa, P., Paniagua-Martin, M.J., Barge-Caballero, E., Laynez Cerdena, I., Famara Hernandez Baldomero, I., Lara Padron, A., Ofelia Rosillo, S., Dalmau Gonzalez-Gallarza, R., Salvador Montanes, O., Iniesta Manjavacas, A.M., Castro Conde, A., Araujo, A., Soria, T., Garcia-Pavia, P., Gomez-Bueno, M., Cobo-Marcos, M., Alonso-Pulpon, L., 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Olsson, L., Afzelius, M., Karlström, P., Tengvall, L., Wiklund, P.-A., Olsson, B., Kalayci, S., Cavusoglu, Y., Gencer, E., Yilmaz, M.B., Gunes, H., Canepa, Marco, Fonseca, Candida, Chioncel, Ovidiu, Laroche, Cécile, Crespo-Leiro, Maria G., Coats, Andrew J.S., Mebazaa, Alexandre, Piepoli, Massimo F., Tavazzi, Luigi, and Maggioni, Aldo P.
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- 2018
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4. Characteristics, management, and outcomes of patients with left-sided infective endocarditis complicated by heart failure: a substudy of the ESC-EORP EURO-ENDO (European infective endocarditis) registry
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M., Vidal B., Falces C., Fuster D., Garcia-de-la-Maria C., Llopis J., Marco F., Ruiz-Zamora I., Bardaji Ruiz A., Sanz Girgas E., Garcia-Pardo G., Guillen Marzo M., Rodriguez Oviedo A., Villares Jimenez A., Abid L., Hammami R., Kammoun S., Mourali M. S., Mghaieth Zghal F., Ben Hlima M., Boudiche S., Ouali S., Zakhama L., Antit S., Slama I., Gulel O., Sahin M., Karacaglar E., Kucukoglu S., Cetinarslan O., Sinan U. Y., Canpolat U., Atas H., Dervishova R., Ileri C., Alhashmi J., Tahir J., Zarger P., Baslib F., Woldman S., Menezes L., Primus C., Uppal R., Bvekerwa I., Chandrasekaran B., Kopanska A., Chambers J., Hancock J., Klein J., Rajani R., Ursi M. P., Cannata S., Dworakowski R., Fife A., Breeze J., Browne-Morgan M., Gunning M., Streather S., Asch F. 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Sengupta, S, Separovic-Hanzevacki, J, Takeuchi, M, Tucay, E, Tude Rodrigues, A, Varga, A, Vaskelyte, J, Yamagata, K, Yiangou, K, Zaky, H, Granada, I, Mahia, M, Ressi, S, Nacinovich, F, Iribarren, A, Fernandez Oses, P, Avegliano, G, Filipini, E, Obregon, R, Bangher, M, Dho, J, Cartasegna, L, Plastino, M, Novas, V, Shigel, C, De Santos, M, Gastaldello, N, Granillo Fernandez, M, Potito, M, Streitenberger, G, Velazco, P, Casabe, J, Cortes, C, Guevara, E, Salmo, F, Seijo, M, Weidinger, F, Heger, M, Brooks, R, Stollberger, C, Ho, C, Perschy, L, Puskas, L, Binder, C, Rosenhek, R, Schneider, M, Winter, M, Hoffer, E, Lecoq, E, Legrand, D, Jacquet, S, Massoz, M, Pierard, L, Marchetta, S, Dulgheru, R, D'Emal, C, Oury, C, Droogmans, S, Kerkhove, D, Plein, D, Soens, L, Weytjens, C, Motoc, A, Roosens, B, Lemoine, I, Rodrigus, I, Paelinck, B, Amsel, B, Unger, P, Konopnicki, D, Beauloye, C, Pasquet, A, Vanoverschelde, J, Pierard, S, Vancraeynest, D, Sinnaeve, F, Andrade, J, Staszko, K, Dos Santos Monteiro, R, Miglioranza, M, Shuha, D, Alcantara, M, Cravo, V, Fazzio, L, Felix, A, Iso, M, Musa, C, Siciliano, A, Villaca Filho, F, Rodrigues, A, Vilela, F, Braga, J, Silva, R, Rodrigues, D, Silva, L, Morhy, S, Fischer, C, Vieira, M, Afonso, T, Abreu, J, Falcao, S, Moises, V, Gouvea, A, Mancuso, F, Souza, A, Silva, C, Joao, G, Abboud, C, Bellio de Mattos Barretto, R, Ramos, A, Arnoni, R, Assef, J, Della Togna, D, Le Bihan, D, Miglioli, L, Romero Oliveira, A, Tadeu Magro Kroll, R, Cortez, D, Gelape, C, Peirira Nunes, M, De Abreu Ferrari, T, Hay, K, Le, V, Page, M, Poulin, F, Sauve, C, Serri, K, Mercure, C, Beaudoin, J, Pibarot, P, Sebag, I, Rudski, L, Ricafort, G, Barsic, B, Krajinovic, V, Vargovic, M, Lovric, D, Reskovic-Luksic, V, Vincelj, J, Jaksic Jurinjak, S, Yiannikourides, V, Ioannides, M, Pofaides, C, Masoura, V, Pudich, J, Linhart, A, Siranec, M, Marek, J, Blechova, K, Kamenik, M, Pelouch, R, Coufal, Z, Mikulica, M, Griva, M, Jancova, E, Mikulcova, M, Taborsky, M, Precek, J, Jecmenova, M, Latal, J, Widimsky, J, Butta, T, Machacek, S, Vancata, R, Spinar, J, Holicka, M, Pow Chon Long, F, Anzules, N, Bajana Carpio, A, Largacha, G, Penaherrera, E, Moreira, D, Mahfouz, E, Elsafty, E, Soliman, A, Zayed, Y, Aboulenein, J, Abdel-Hay, M, Almaghraby, A, Abdelnaby, M, Ahmed, M, Hammad, B, Saleh, Y, Zahran, H, Elgebaly, O, Saad, A, Ali, M, Zeid, A, El Sharkawy, R, Al Kholy, A, Doss, R, Osama, D, Rizk, H, Elmogy, A, Mishriky, M, Assayag, P, El Hatimi, S, Hubert, S, Casalta, J, Gouriet, F, Arregle, F, Cammilleri, S, Tessonnier, L, Riberi, A, Botelho-Nevers, E, Gagneux-Brunon, A, Pierrard, R, Tulane, C, Campisi, S, Fuzellier, J, Detoc, M, Mehalla, T, Boutoille, D, Lecompte, A, Lefebvre, M, Pattier, S, Al Habash, O, Asseray-Madani, N, Biron, C, Brochard, J, Caillon, J, Cueff, C, Le Tourneau, T, Lecomte, R, Magali Michel, M, Orain, J, Delarue, S, Le Bras, M, Faucher, J, Aboyans, V, Beeharry, A, Durox, H, Lacoste, M, Magne, J, Mohty, D, David, A, Pradel, V, Sierra, V, Neykova, A, Bettayeb, B, Elkentaoui, S, Tzvetkov, B, Landry, G, Strady, C, Ainine, K, Baumard, S, Brasselet, C, Tassigny, C, Valente-Pires, V, Lefranc, M, Hoen, B, Lefevre, B, Curlier, E, Callier, C, Fourcade, N, Jobic, Y, Ansard, S, Le Berre, R, Le Ven, F, Pouliquen, M, Prat, G, Le Roux, P, Bouchart, F, Savoure, A, Alarcon, C, Chapuzet, C, Gueit, I, Peugnet, F, Gun, M, Duval, X, Lescure, X, Ilic-Habensus, E, Sadoul, N, Selton-Suty, C, Alla, F, Goehringer, F, Huttin, O, Chevalier, E, Garcia, R, Le Marcis, V, Tattevin, P, Flecher, E, Revest, M, Bouiller, K, Hustache-Mathieu, L, Klopfenstein, T, Moreau, J, Fournier, D, Brunel, A, Lim, P, Oliver, L, Ternacle, J, Moussafeur, A, Chavanet, P, Piroth, L, Salmon-Rousseau, A, Buisson, M, Mahy, S, Martins, C, Gohier, S, Axler, O, Baumann, F, Lebras, S, Piper, C, Guckel, D, Borgermann, J, Horstkotte, D, Winkelmann, E, Brockmeier, B, Grey, D, Nickenig, G, Schueler, R, Ozturk, C, Hamm, C, Walther, T, Brandt, R, Fruhauf, A, Hartung, C, Hellner, C, 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Del Pace, S, Stefano, P, Sparano, C, Ruozi, N, Tenaglia, R, Muraru, D, Limbruno, U, Cresti, A, Baratta, P, Solari, M, Giannattasio, C, Moreo, A, De Chiara, B, Lopez Montero, B, Musca, F, Orcese, C, Panzeri, F, Spano, F, Russo, C, Alfieri, O, De Bonis, M, Chiappetta, S, Del Forno, B, Ripa, M, Scarpellini, P, Tassan Din, C, Castiglioni, B, Pasciuta, R, Carletti, S, Ferrara, D, Guffanti, M, Iaci, G, Lapenna, E, Nisi, T, Oltolini, C, Busnardo, E, Pajoro, U, Agricola, E, Meneghin, R, Schiavi, D, Piscione, F, Citro, R, Benvenga, R, Greco, L, Soriente, L, Radano, I, Prota, C, Bellino, M, Di Vece, D, Santini, F, Salsano, A, Olivieri, G, Turrini, F, Messora, R, Tondi, S, Olaru, A, Agnoletto, V, Grassi, L, Leonardi, C, Sansoni, S, Del Ponte, S, Actis Dato, G, De Martino, A, Ohte, N, Kikuchi, S, Wakami, K, Aonuma, K, Seo, Y, Ishizu, T, Machino-Ohtsuka, T, Yamamoto, M, Iida, N, Nakajima, H, Nakagawa, Y, Izumi, C, Amano, M, Miyake, M, Takahashi, K, Shiojima, I, Miyasaka, Y, Maeba, H, Suwa, Y, 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Jimbei, P, Balan, G, Cardaniuc, I, Benesco, I, Marian, V, Sumarga, N, Bozovic, B, Bulatovic, N, Lakovic, P, Music, L, Budde, R, Wahadat, A, Gamela, T, Meijers, T, Van Melle, J, Deursen, V, Crijns, H, Bekkers, S, Cheriex, E, Gilbers, M, Kietselaer, B, Knackstedt, C, Lorusso, R, Schalla, S, Streukens, S, Chamuleau, S, Cramer, M, Teske, A, Van der Spoel, T, Wind, A, Lokhorst, J, Liesbek, O, Van Heusden, H, Tanis, W, Van der Bilt, I, Vriend, J, De Lange-van Bruggen, H, Karijodikoro, E, Riezebos, R, van Dongen, E, Schoep, J, Stolk, V, Offstad, J, Beitnes, J, Helle-Valle, T, Skulstad, H, Skardal, R, Qamar, N, Furnaz, S, Ahmed, B, Butt, M, Khanzada, M, Saghir, T, Wahid, A, Hryniewiecki, T, Szymanski, P, Marzec, K, Misztal-Ogonowska, M, Kosmala, W, Przewlocka-Kosmala, M, Rojek, A, Woznicka, K, Zachwyc, J, Lisowska, A, Kaminska, M, Kasprzak, J, Kowalczyk, E, Strzecka, D, Wejner-Mik, P, Trabulo, M, Freitas, P, Ranchordas, S, Rodrigues, G, Pinto, P, Queiros, C, Azevedo, J, Marques, L, Seabra, D, Cruz, M, Galrinho, A, Moreira, R, Rio, P, Timoteo, A, Selas, M, Carmelo, V, Duque Neves, B, Pereira, H, Guerra, A, Marques, A, Pintassilgo, I, Tomescu, M, Trofenciuc, N, Andor, M, Bordejevic, A, Branea, H, Caruntu, F, Velcean, L, Mavrea, A, Onel, M, Parvanescu, T, Pop, D, Pop-Moldovan, A, Puticiu, M, Cirin, L, Citu, I, Cotoraci, C, Darabantiu, D, Farcas, R, Marincu, I, Ionac, A, Cozma, D, Mornos, C, Goanta, F, Popescu, I, Beyer, R, Mada, R, Rancea, R, Tomoaia, R, Rosianu, H, Stanescu, C, Kobalava, Z, Karaulova, J, Kotova, E, Milto, A, Pisaryuk, A, Povalyaev, N, Sorokina, M, Alrahimi, J, Elshiekh, A, Jamiel, A, Ahmed, A, Attia, N, Putnikovic, B, Dimic, A, Ivanovic, B, Matic, S, Trifunovic, D, Petrovic, J, Kosevic, D, Stojanovic, I, Petrovic, I, Dabic, P, Milojevic, P, Srdanovic, I, Susak, S, Velicki, L, Vulin, A, Kovacevic, M, Redzek, A, Stefanovic, M, Yeo, T, Poh, K, Vilacosta, I, Ferrera, C, Abd El- Nasser, M, Calvo Iglesias, F, Blanco-Gonzalez, E, Bravo Amaro, M, Lopez-Rodriguez, E, Lugo Adan, J, Germinas, A, Pazos-Lopez, P, Pereira Loureiro, M, Perez, M, Raposeiras-Roubin, S, Rasheed Yas, S, Suarez-Varela, M, Vasallo Vidal, F, Garcia-Dorado, D, Fernandez-Hidalgo, N, Gonzalez-Alujas, T, Lozano, J, Maisterra, O, Pizzi, N, Rios, R, Bayes-Genis, A, Pedro Botet, L, Vallejo, N, Llibre, C, Mateu, L, Nunez, R, Quesada, D, Berastegui, E, Bosch Portell, D, Aboal Vinas, J, Albert Bertran, X, Brugada Tarradellas, R, Loma-Osorio Ricon, P, Tiron de Llano, C, Arnau, M, Bel, A, Blanes, M, Osa, A, Anguita, M, Carrasco, F, Castillo, J, Zamorano, J, Moya Mur, J, Alvaro, M, Fernandez-Golfin, C, Monteagudo, J, Navas Elorza, E, Farinas Alvarez, M, Aguero Balbin, J, Zarauza, J, Gutierrez-Diez, J, Arminanzas, C, Arnaiz de las Revillas, F, Arnaiz Garcia, A, Cobo Belaustegui, M, Fernandez Sampedro, M, Gutierrez Cuadra, M, Garcia Cuello, L, Gonzalez Rico, C, Rodriguez-Alvarez, R, Goikoetxea, J, Montejo, M, Miro, J, Almela, M, Ambrosioni, J, Moreno, A, Quintana, E, Sandoval, E, Tellez, A, Tolosana, J, Vidal, B, Falces, C, Fuster, D, Garcia-de-la-Maria, C, Llopis, J, Marco, F, Ruiz-Zamora, I, Bardaji Ruiz, A, Sanz Girgas, E, Garcia-Pardo, G, Guillen Marzo, M, Rodriguez Oviedo, A, Villares Jimenez, A, Abid, L, Hammami, R, Kammoun, S, Mourali, M, Mghaieth Zghal, F, Ben Hlima, M, Boudiche, S, Ouali, S, Zakhama, L, Antit, S, Slama, I, Gulel, O, Sahin, M, Karacaglar, E, Kucukoglu, S, Cetinarslan, O, Sinan, U, Canpolat, U, Atas, H, Dervishova, R, Ileri, C, Alhashmi, J, Tahir, J, Zarger, P, Baslib, F, Woldman, S, Menezes, L, Primus, C, Uppal, R, Bvekerwa, I, Chandrasekaran, B, Kopanska, A, Chambers, J, Hancock, J, Klein, J, Rajani, R, Ursi, M, Cannata, S, Dworakowski, R, Fife, A, Breeze, J, Browne-Morgan, M, Gunning, M, Streather, S, Asch, F, Zemedkun, M, Alyavi, B, Uzokov, J, Bohbot Y., Habib G., Laroche C., Stohr E., Chirouze C., Hernandez-Meneses M., Melissopoulou M., Mutlu B., Scheggi V., Branco L., Olmos C., Reyes G., Pazdernik M., Iung B., Sow R., Mirocevic M., Lancellotti P., Tribouilloy C., Gale C. P., Beleslin B., Budaj A., Chioncel O., Dagres N., Danchin N., Emberson J., Erlinge D., Glikson M., Gray A., Kayikcioglu M., Maggioni A. P., Nagy V. K., Nedoshivin A., Petronio A. -S., Roos-Hesselink J., Wallentin L., Zeymer U., Cosyns B., Donal E., Erba P., Popescu B. A., Prendergast B., Tornos P., Andarala M., Berle C., Brunel-Lebecq A., Fiorucci E., Missiamenou V., Taylor C., Ali Tatar-Chentir N. N., Al-Mallah M., Astrom Aneq M., Athanassopoulos G., Badano L., Benyoussef S., Calderon Aranda E., Cardim N. M., Chan K. -L., Cruz I., Edvardsen T., Goliasch G., Hagendorff A., Hristova K., Kamp O., Kang D. -H., Kong W., Matskeplishvili S., Meshaal M., Neskovic A. N., Plonska-Gosciniak E., Raissouni M., Ronderos R., Sade L. E., Sadeghpour A., Sambola A., Sengupta S., Separovic-Hanzevacki J., Takeuchi M., Tucay E., Tude Rodrigues A. C., Varga A., Vaskelyte J., Yamagata K., Yiangou K., Zaky H., Granada I., Mahia M., Ressi S., Nacinovich F., Iribarren A., Fernandez Oses P., Avegliano G., Filipini E., Obregon R., Bangher M., Dho J., Cartasegna L., Plastino M. L., Novas V., Shigel C., De Santos M., Gastaldello N., Granillo Fernandez M., Potito M., Streitenberger G., Velazco P., Casabe J. H., Cortes C., Guevara E., Salmo F., Seijo M., Weidinger F., Heger M., Brooks R., Stollberger C., Ho C. -Y., Perschy L., Puskas L., Binder C., Rosenhek R., Schneider M., Winter M. -P., Hoffer E., Lecoq E., Legrand D., Jacquet S., Massoz M., Pierard L., Marchetta S., Dulgheru R., D'Emal C., Oury C., Droogmans S., Kerkhove D., Plein D., Soens L., Weytjens C., Motoc A., Roosens B., Lemoine I., Rodrigus I., Paelinck B., Amsel B., Unger P., Konopnicki D., Beauloye C., Pasquet A., Vanoverschelde J. L., Pierard S., Vancraeynest D., Sinnaeve F., Andrade J. L., Staszko K., Dos Santos Monteiro R., Miglioranza M. H., Shuha D. L., Alcantara M., Cravo V., Fazzio L., Felix A., Iso M., Musa C., Siciliano A. P., Villaca Filho F., Rodrigues A., Vilela F., Braga J., Silva R., Rodrigues D., Silva L., Morhy S., Fischer C., Vieira M., Afonso T., Abreu J., Falcao S. N., Moises V. A., Gouvea A., Mancuso F. J., Souza A. C., Silva C. Y., Joao G., Abboud C. S., Bellio de Mattos Barretto R., Ramos A., Arnoni R., Assef J. E., Della Togna D. J., Le Bihan D., Miglioli L., Romero Oliveira A. P., Tadeu Magro Kroll R., Cortez D., Gelape C. L., Peirira Nunes M., De Abreu Ferrari T. C., Hay K., Le V., Page M., Poulin F., Sauve C., Serri K., Mercure C., Beaudoin J., Pibarot P., Sebag I. A., Rudski L. G., Ricafort G., Barsic B., Krajinovic V., Vargovic M., Lovric D., Reskovic-Luksic V., Vincelj J., Jaksic Jurinjak S., Yiannikourides V., Ioannides M., Pofaides C., Masoura V., Pudich J., Linhart A., Siranec M., Marek J., Blechova K., Kamenik M., Pelouch R., Coufal Z., Mikulica M., Griva M., Jancova E., Mikulcova M., Taborsky M., Precek J., Jecmenova M., Latal J., Widimsky J., Butta T., Machacek S., Vancata R., Spinar J., Holicka M., Pow Chon Long F., Anzules N., Bajana Carpio A., Largacha G., Penaherrera E., Moreira D., Mahfouz E., Elsafty E., Soliman A., Zayed Y., Aboulenein J., Abdel-Hay M., Almaghraby A., Abdelnaby M., Ahmed M., Hammad B., Saleh Y., Zahran H., Elgebaly O., Saad A., Ali M., Zeid A., El Sharkawy R., Al Kholy A., Doss R., Osama D., Rizk H., Elmogy A., Mishriky M., Assayag P., El Hatimi S., Hubert S., Casalta J. -P., Gouriet F., Arregle F., Cammilleri S., Tessonnier L., Riberi A., Botelho-Nevers E., Gagneux-Brunon A., Pierrard R., Tulane C., Campisi S., Fuzellier J. -F., Detoc M., Mehalla T., Boutoille D., Lecompte A. S., Lefebvre M., Pattier S., Al Habash O., Asseray-Madani N., Biron C., Brochard J., Caillon J., Cueff C., Le Tourneau T., Lecomte R., Magali Michel M. M., Orain J., Delarue S., Le Bras M., Faucher J. -F., Aboyans V., Beeharry A., Durox H., Lacoste M., Magne J., Mohty D., David A., Pradel V., Sierra V., Neykova A., Bettayeb B., Elkentaoui S., Tzvetkov B., Landry G., Strady C., Ainine K., Baumard S., Brasselet C., Tassigny C., Valente-Pires V., Lefranc M., Hoen B., Lefevre B., Curlier E., Callier C., Fourcade N., Jobic Y., Ansard S., Le Berre R., Le Ven F., Pouliquen M. -C., Prat G., Le Roux P., Bouchart F., Savoure A., Alarcon C., Chapuzet C., Gueit I., Peugnet F., Gun M., Duval X., Lescure X., Ilic-Habensus E., Sadoul N., Selton-Suty C., Alla F., Goehringer F., Huttin O., Chevalier E., Garcia R., Le Marcis V., Tattevin P., Flecher E., Revest M., Bouiller K., Hustache-Mathieu L., Klopfenstein T., Moreau J., Fournier D., Brunel A. -S., Lim P., Oliver L., Ternacle J., Moussafeur A., Chavanet P., Piroth L., Salmon-Rousseau A., Buisson M., Mahy S., Martins C., Gohier S., Axler O., Baumann F., Lebras S., Piper C., Guckel D., Borgermann J., Horstkotte D., Winkelmann E., Brockmeier B., Grey D., Nickenig G., Schueler R., Ozturk C., Hamm C., Walther T., Brandt R., Fruhauf A. -C., Hartung C. T., Hellner C., Wild C., Becker M., Hamada S., Kaestner W., Stangl K., Knebel F., Baldenhofer G., Brecht A., Dreger H., Isner C., Pfafflin F., Stegemann M., Zahn R., Fraiture B., Kilkowski C., Karcher A. -K., Klinger S., Tolksdorf H., Tousoulis D., Aggeli C., Sideris S., Venieri E., Sarri G., Tsiapras D., Armenis I., Koutsiari A., Floros G., Grassos C., Dragasis S., Rallidis L., Varlamos C., Michalis L., Naka K., Bechlioulis A., Kotsia A., Lakkas L., Pappas K., Papadopoulos C., Kiokas S., Lioni A., Misailidou S., Barbetseas J., Bonou M., Kapelios C., Tomprou I., Zerva K., Manolis A., Hamodraka E., Athanasiou D., Haralambidis G., Samaras H., Poulimenos L., Nagy A., Bartykowszki A., Gara E., Mungulmare K., Kasliwal R., Bansal M., Ranjan S., Bhan A., Kyavar M., Maleki M., Bezanjani F. N., Alizadehasl A., Boudagh S., Ghavidel A., Moradnejad P., Pasha H. R., Ghadrdoost B., Gilon D., Strahilevitz J., Wanounou M., Israel S., d'Agostino C., Colonna P., De Michele L., Fumarola F., Stante M., Marchionni N., Alterini B., Del Pace S., Stefano P., Sparano C., Ruozi N., Tenaglia R., Muraru D., Limbruno U., Cresti A., Baratta P., Solari M., Giannattasio C., Moreo A., De Chiara B., Lopez Montero B., Musca F., Orcese C. A., Panzeri F., Spano F., Russo C. F., Alfieri O., De Bonis M., Chiappetta S., Del Forno B., Ripa M., Scarpellini P., Tassan Din C., Castiglioni B., Pasciuta R., Carletti S., Ferrara D., Guffanti M., Iaci G., Lapenna E., Nisi T., Oltolini C., Busnardo E., Pajoro U., Agricola E., Meneghin R., Schiavi D., Piscione F., Citro R., Benvenga R. M., Greco L., Soriente L., Radano I., Prota C., Bellino M., Di Vece D., Santini F., Salsano A., Olivieri G. M., Turrini F., Messora R., Tondi S., Olaru A., Agnoletto V., Grassi L., Leonardi C., Sansoni S., Del Ponte S., Actis Dato G. M., De Martino A., Ohte N., Kikuchi S., Wakami K., Aonuma K., Seo Y., Ishizu T., Machino-Ohtsuka T., Yamamoto M., Iida N., Nakajima H., Nakagawa Y., Izumi C., Amano M., Miyake M., Takahashi K., Shiojima I., Miyasaka Y., Maeba H., Suwa Y., Taniguchi N., Tsujimoto S., Kitai T., Ota M., Yuda S., Sasaki S., Hagiwara N., Yamazaki K., Ashihara K., Arai K., Saitou C., Saitou S., Suzuki G., Shibata Y., Watanabe N., Nishino S., Ashikaga K., Kuriyama N., Mahara K., Okubo T., Fujimaki H., Shitan H., Yamamoto H., Abe K., Terada M., Takanashi S., Sata M., Yamada H., Kusunose K., Saijo Y., Seno H., Yuichiro O., Onishi T., Sera F., Nakatani S., Mizuno H., Sengoku K., Park S. W., Kyoung K. E., Yeon L. G., Hwang J. -W., Jin-Oh C., Park S. -J., Sang-Chol L., Sung-A C., Jang S. Y., Heo R., Lee S., Song J. -M., Jung E., Plisiene J., Dambrauskaite A., Gruodyte G., Jonkaitiene R., Mizariene V., Atkocaityte J., Zvirblyte R., Codreanu A., Staub T., Michaux C., De la Vega E. C. L., Jacobs-Orazi L., Mallia Azzopardi C., Xuereb R. G., Piscopo T., Farrugia J., Fenech M., Pllaha E., Vella C., Borg D., Casha R., Grib L., Raevschi E., Grejdieru A., Kravcenco D., Prisacari E., Samohvalov E., Samohvalov S., Sceglova N., Panfile E., Cardaniuc L., Corcea V., Feodorovici A., Gaina V., Girbu L., Jimbei P., Balan G., Cardaniuc I., Benesco I., Marian V., Sumarga N., Bozovic B., Bulatovic N., Lakovic P., Music L., Budde R., Wahadat A., Gamela T., Meijers T., Van Melle J. P., Deursen V. M., Crijns H. J., Bekkers S. C., Cheriex E. C., Gilbers M., Kietselaer B. L., Knackstedt C., Lorusso R., Schalla S., Streukens S. A., Chamuleau S., Cramer M. -J., Teske A., Van der Spoel T., Wind A., Lokhorst J., Liesbek O., Van Heusden H., Tanis W., Van der Bilt I., Vriend J., De Lange-van Bruggen H., Karijodikoro E., Riezebos R., van Dongen E., Schoep J., Stolk V., Offstad J. T., Beitnes J. O., Helle-Valle T., Skulstad H., Skardal R., Qamar N., Furnaz S., Ahmed B., Butt M. H., Khanzada M. F., Saghir T., Wahid A., Hryniewiecki T., Szymanski P., Marzec K., Misztal-Ogonowska M., Kosmala W., Przewlocka-Kosmala M., Rojek A., Woznicka K., Zachwyc J., Lisowska A., Kaminska M., Kasprzak J. D., Kowalczyk E., Strzecka D. F., Wejner-Mik P., Trabulo M., Freitas P., Ranchordas S., Rodrigues G., Pinto P., Queiros C., Azevedo J., Marques L., Seabra D., Cruz M., Galrinho A., Moreira R., Rio P., Timoteo A. T., Selas M., Carmelo V., Duque Neves B., Pereira H., Guerra A., Marques A., Pintassilgo I., Tomescu M. C., Trofenciuc N. -M., Andor M., Bordejevic A., Branea H. S., Caruntu F., Velcean L. A., Mavrea A., Onel M. F., Parvanescu T., Pop D., Pop-Moldovan A. L., Puticiu M. I., Cirin L., Citu I. M., Cotoraci C. A., Darabantiu D., Farcas R., Marincu I., Ionac A., Cozma D., Mornos C., Goanta F., Popescu I., Beyer R., Mada R., Rancea R., Tomoaia R., Rosianu H., Stanescu C., Kobalava Z., Karaulova J., Kotova E., Milto A., Pisaryuk A., Povalyaev N., Sorokina M., Alrahimi J., Elshiekh A., Jamiel A., Ahmed A., Attia N., Putnikovic B., Dimic A., Ivanovic B., Matic S., Trifunovic D., Petrovic J., Kosevic D., Stojanovic I., Petrovic I., Dabic P., Milojevic P., Srdanovic I., Susak S., Velicki L., Vulin A., Kovacevic M., Redzek A., Stefanovic M., Yeo T. C., Kong W. K. F., Poh K. K., Vilacosta I., Ferrera C., Abd El- Nasser M., Calvo Iglesias F., Blanco-Gonzalez E., Bravo Amaro M., Lopez-Rodriguez E., Lugo Adan J., Germinas A. N., Pazos-Lopez P., Pereira Loureiro M., Perez M. T., Raposeiras-Roubin S., Rasheed Yas S., Suarez-Varela M. -M., Vasallo Vidal F., Garcia-Dorado D., Fernandez-Hidalgo N., Gonzalez-Alujas T., Lozano J., Maisterra O., Pizzi N., Rios R., Bayes-Genis A., Pedro Botet L., Vallejo N., Llibre C., Mateu L., Nunez R., Quesada D., Berastegui E., Bosch Portell D., Aboal Vinas J., Albert Bertran X., Brugada Tarradellas R., Loma-Osorio Ricon P., Tiron de Llano C., Arnau M. A., Bel A., Blanes M., Osa A., Anguita M., Carrasco F., Castillo J. C., Zamorano J. L., Moya Mur J. L., Alvaro M., Fernandez-Golfin C., Monteagudo J. M., Navas Elorza E., Farinas Alvarez M. C., Aguero Balbin J., Zarauza J., Gutierrez-Diez J. F., Arminanzas C., Arnaiz de las Revillas F., Arnaiz Garcia A., Cobo Belaustegui M., Fernandez Sampedro M., Gutierrez Cuadra M., Garcia Cuello L., Gonzalez Rico C., Rodriguez-Alvarez R., Goikoetxea J., Montejo M., Miro J. M., Almela M., Ambrosioni J., Moreno A., Quintana E., Sandoval E., Tellez A., Tolosana J. M., Vidal B., Falces C., Fuster D., Garcia-de-la-Maria C., Llopis J., Marco F., Ruiz-Zamora I., Bardaji Ruiz A., Sanz Girgas E., Garcia-Pardo G., Guillen Marzo M., Rodriguez Oviedo A., Villares Jimenez A., Abid L., Hammami R., Kammoun S., Mourali M. S., Mghaieth Zghal F., Ben Hlima M., Boudiche S., Ouali S., Zakhama L., Antit S., Slama I., Gulel O., Sahin M., Karacaglar E., Kucukoglu S., Cetinarslan O., Sinan U. Y., Canpolat U., Atas H., Dervishova R., Ileri C., Alhashmi J., Tahir J., Zarger P., Baslib F., Woldman S., Menezes L., Primus C., Uppal R., Bvekerwa I., Chandrasekaran B., Kopanska A., Chambers J., Hancock J., Klein J., Rajani R., Ursi M. P., Cannata S., Dworakowski R., Fife A., Breeze J., Browne-Morgan M., Gunning M., Streather S., Asch F. M., Zemedkun M., Alyavi B., and Uzokov J.
- Abstract
Aims: To evaluate the current management and survival of patients with left-sided infective endocarditis (IE) complicated by congestive heart failure (CHF) in the ESC-EORP European Endocarditis (EURO-ENDO) registry. Methods and results: Among the 3116 patients enrolled in this prospective registry, 2449 (mean age: 60 years, 69% male) with left-sided (native or prosthetic) IE were included in this study. Patients with CHF (n = 698, 28.5%) were older, with more comorbidity and more severe valvular damage (mitro-aortic involvement, vegetations >10 mm and severe regurgitation/new prosthesis dehiscence) than those without CHF (all p ≤ 0.019). Patients with CHF experienced higher 30-day and 1-year mortality than those without (20.5% vs. 9.0% and 36.1% vs. 19.3%, respectively) and CHF remained strongly associated with 30-day (odds ratio[OR] 2.37, 95% confidence interval [CI] [1.73–3.24; p < 0.001) and 1-year mortality (hazard ratio [HR] 1.69, 95% CI 1.39–2.05; p < 0.001) after adjustment for established outcome predictors, including early surgery, or after propensity matching for age, sex, and comorbidity (n = 618 [88.5%] for each group, both p < 0.001). Early surgery, performed on 49% of these patients with IE complicated by CHF, remained associated with a substantial reduction in 30-day mortality following multivariable analysis, after adjustment for age, sex, Charlson comorbidity index, cerebrovascular accident, Staphylococcus aureus IE, streptococcal IE, uncontrolled infection, vegetation size >10 mm, severe valvular regurgitation and/or new prosthetic dehiscence, perivalvular complication, and prosthetic IE (OR 0.22, 95% CI 0.12–0.38; p < 0.001) and in 1-year mortality (HR 0.29, 95% CI 0.20–0.41; p < 0.001). Conclusion: Congestive heart failure is common in left-sided IE and is associated with older age, greater comorbidity, more advanced lesions, and markedly higher 30-day and 1-year mortality. Early surgery is strongly associated with lower mort
- Published
- 2022
5. Characteristics, management, and outcomes of patients with left-sided infective endocarditis complicated by heart failure:a substudy of the ESC-EORP EURO-ENDO (European infective endocarditis) registry
- Author
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Bohbot, Yohann, Habib, Gilbert, Laroche, Cécile, Stöhr, Elisabeth, Chirouze, Catherine, Hernandez-Meneses, Marta, Melissopoulou, Maria, Mutlu, Bülent, Scheggi, Valentina, Branco, Luísa, Olmos, Carmen, Reyes, Graciela, Pazdernik, Michal, Iung, Bernard, Sow, Rouguiatou, Mirocevic, Maja, Lancellotti, Patrizio, Tribouilloy, Christophe, P Gale, C, Beleslin, B, Budaj, A, Chioncel, O, Dagres, N, Danchin, N, Emberson, J, Erlinge, D, Glikson, M, Gray, A, Kayikcioglu, M, P Maggioni, A, K Nagy, V, Nedoshivin, A, A-S, Petronio, Roos-Hesselink, J, Wallentin, L, Zeymer, U, Habib, G, Lancellotti, P, Cosyns, B, Donal, E, Erba, P, Iung, B, A Popescu, B, Prendergast, B, Tornos, P, Andarala, M, Berle, C, Brunel-Lebecq, A, Fiorucci, E, Laroche, C, Missiamenou, V, Taylor, C, N Ali Tatar-Chentir, N, Al-Mallah, M, M Astrom Aneq, Athanassopoulos, G, P Badano, L, Benyoussef, S, E Calderon Aranda, M Cardim, N, K-L, Chan, Cruz, I, Edvardsen, T, Goliasch, G, Hagendorff, A, Hristova, K, Kamp, O, D-H, Kang, Kong, 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M, Kietselaer, B, Knackstedt, C, Lorusso, R, Schalla, S, Streukens, S, Chamuleau, S, Cramer, M, Teske, A, Van der Spoel, T, Wind, A, Lokhorst, J, Liesbek, O, Van Heusden, H, Tanis, W, Van der Bilt, I, Vriend, J, De Lange-van Bruggen, H, Karijodikoro, E, Riezebos, R, van Dongen, E, Schoep, J, Stolk, V, Offstad, J, Beitnes, J, Helle-Valle, T, Skulstad, H, Skardal, R, Qamar, N, Furnaz, S, Ahmed, B, Butt, M, Khanzada, M, Saghir, T, Wahid, A, Hryniewiecki, T, Szymanski, P, Marzec, K, Misztal-Ogonowska, M, Kosmala, W, Przewlocka-Kosmala, M, Rojek, A, Woznicka, K, Zachwyc, J, Lisowska, A, Kaminska, M, Kasprzak, J, Kowalczyk, E, Strzecka, D, Wejner-Mik, P, Trabulo, M, Freitas, P, Ranchordas, S, Rodrigues, G, Pinto, P, Queiros, C, Azevedo, J, Marques, L, Seabra, D, Cruz, M, Galrinho, A, Moreira, R, Rio, P, Timoteo, A, Selas, M, Carmelo, V, Duque Neves, B, Pereira, H, Guerra, A, Marques, A, Pintassilgo, I, Tomescu, M, Trofenciuc, N, Andor, M, Bordejevic, A, Branea, H, Caruntu, F, Velcean, L, Mavrea, A, Onel, M, Parvanescu, T, Pop, D, Pop-Moldovan, A, Puticiu, M, Cirin, L, Citu, I, Cotoraci, C, Darabantiu, D, Farcas, R, Marincu, I, Ionac, A, Cozma, D, Mornos, C, Goanta, F, Popescu, I, Beyer, R, Mada, R, Rancea, R, Tomoaia, R, Rosianu, H, Stanescu, C, Kobalava, Z, Karaulova, J, Kotova, E, Milto, A, Pisaryuk, A, Povalyaev, N, Sorokina, M, Alrahimi, J, Elshiekh, A, Jamiel, A, Ahmed, A, Attia, N, Putnikovic, B, Dimic, A, Ivanovic, B, Matic, S, Trifunovic, D, Petrovic, J, Kosevic, D, Stojanovic, I, Petrovic, I, Dabic, P, Milojevic, P, Srdanovic, I, Susak, S, Velicki, L, Vulin, A, Kovacevic, M, Redzek, A, Stefanovic, M, Yeo, T, Poh, K, Vilacosta, I, Ferrera, C, Abd El- Nasser, M, Calvo Iglesias, F, Blanco-Gonzalez, E, Bravo Amaro, M, Lopez-Rodriguez, E, Lugo Adan, J, Germinas, A, Pazos-Lopez, P, Pereira Loureiro, M, Perez, M, Raposeiras-Roubin, S, Rasheed Yas, S, Suarez-Varela, M, Vasallo Vidal, F, Garcia-Dorado, D, Fernandez-Hidalgo, N, Gonzalez-Alujas, T, Lozano, J, Maisterra, O, Pizzi, N, Rios, R, Bayes-Genis, A, Pedro Botet, L, Vallejo, N, Llibre, C, Mateu, L, Nunez, R, Quesada, D, Berastegui, E, Bosch Portell, D, Aboal Vinas, J, Albert Bertran, X, Brugada Tarradellas, R, Loma-Osorio Ricon, P, Tiron de Llano, C, Arnau, M, Bel, A, Blanes, M, Osa, A, Anguita, M, Carrasco, F, Castillo, J, Zamorano, J, Moya Mur, J, Alvaro, M, Fernandez-Golfin, C, Monteagudo, J, Navas Elorza, E, Farinas Alvarez, M, Aguero Balbin, J, Zarauza, J, Gutierrez-Diez, J, Arminanzas, C, Arnaiz de las Revillas, F, Arnaiz Garcia, A, Cobo Belaustegui, M, Fernandez Sampedro, M, Gutierrez Cuadra, M, Garcia Cuello, L, Gonzalez Rico, C, Rodriguez-Alvarez, R, Goikoetxea, J, Montejo, M, Miro, J, Almela, M, Ambrosioni, J, Moreno, A, Quintana, E, Sandoval, E, Tellez, A, Tolosana, J, Vidal, B, Falces, C, Fuster, D, Garcia-de-la-Maria, C, Llopis, J, Marco, F, Ruiz-Zamora, I, Bardaji Ruiz, A, Sanz Girgas, E, Garcia-Pardo, G, Guillen Marzo, M, Rodriguez Oviedo, A, Villares Jimenez, A, Abid, L, Hammami, R, Kammoun, S, Mourali, M, Mghaieth Zghal, F, Ben Hlima, M, Boudiche, S, Ouali, S, Zakhama, L, Antit, S, Slama, I, Gulel, O, Sahin, M, Karacaglar, E, Kucukoglu, S, Cetinarslan, O, Sinan, U, Canpolat, U, Atas, H, Dervishova, R, Ileri, C, Alhashmi, J, Tahir, J, Zarger, P, Baslib, F, Woldman, S, Menezes, L, Primus, C, Uppal, R, Bvekerwa, I, Chandrasekaran, B, Kopanska, A, Chambers, J, Hancock, J, Klein, J, Rajani, R, Ursi, M, Cannata, S, Dworakowski, R, Fife, A, Breeze, J, Browne-Morgan, M, Gunning, M, Streather, S, Asch, F, Zemedkun, M, Alyavi, B, and Uzokov, J
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Male ,Congestive heart failure ,Survival ,SURGERY ,IMPACT ,Hospital mortality ,Infective endocarditi ,Sağlık Bilimleri ,Cardiovascular ,Clinical Medicine (MED) ,Endocarditis, Bacterial/complications ,PROGNOSTIC-FACTORS ,KALP VE KALP DAMAR SİSTEMLERİ ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Early surgery ,Klinik Tıp (MED) ,Prospective Studies ,Registries ,PREDICTORS ,ComputingMilieux_MISCELLANEOUS ,Outcome ,RISK ,[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases ,Klinik Tıp ,DEATH ,Middle Aged ,Tıp ,Heart Failure/complications ,[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology ,Medicine ,Female ,EURO-ENDO ,Cardiology and Cardiovascular Medicine ,Kardiyoloji ,Kardiyoloji ve Kardiyovasküler Tıp ,NATIVE VALVE ENDOCARDITIS ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Endocarditis/complications ,Health Sciences ,Humans ,[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology ,Retrospective Studies ,Internal Medicine Sciences ,MORTALITY ,MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE ,Dahili Tıp Bilimleri ,ADULTS ,Infective endocarditis ,CLINICAL MEDICINE ,[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology ,CARDIAC & CARDIOVASCULAR SYSTEMS - Abstract
International audience; AIMS: To evaluate the current management and survival of patients with left-sided infective endocarditis (IE) complicated by congestive heart failure (CHF) in the ESC-EORP European Endocarditis (EURO-ENDO) registry. METHODS AND RESULTS: Among the 3116 patients enrolled in this prospective registry, 2449 (mean age: 60 years, 69% male) with left-sided (native or prosthetic) IE were included in this study. Patients with CHF (n~=~698, 28.5%) were older, with more comorbidity and more severe valvular damage (mitro-aortic involvement, vegetations >10\,mm and severe regurgitation/new prosthesis dehiscence) than those without CHF (all p\,≤q\,0.019). Patients with CHF experienced higher 30-day and 1-year mortality than those without (20.5% vs. 9.0% and 36.1% vs. 19.3%, respectively) and CHF remained strongly associated with 30-day (odds ratio[OR] 2.37, 95% confidence interval [CI] [1.73-3.24; p\,10\,mm, severe valvular regurgitation and/or new prosthetic dehiscence, perivalvular complication, and prosthetic IE (OR 0.22, 95% CI 0.12-0.38; p\
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- 2022
6. ST Segment Elevation Myocardial Infarction Due to Severe Ostial Left Main Stem Stenosis in a Patient with Syphilitic Aortitis
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Predescu L.M., Zarma L., Platon P., Postu M., Bucsa A., Croitoru M., Prodan B., Chioncel O., and Delean D.
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myocardial infarction ,left main stem stenosis ,syphilitic aortitis ,Internal medicine ,RC31-1245 - Abstract
Cardiovascular manifestations of tertiary syphilis infections are uncommon, but represent an important cause of mortality and morbidity. Syphilitic aortitis is characterized by aortic regurgitation, dilatation of ascending aorta and ostial coronary artery lesions.
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- 2016
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7. Socio-Economic Variations Determine the Clinical Presentation, Aetiology and Outcome of Infective Endocarditis: a Prospective Cohort Study from the ESC-EORP EURO-ENDO (European Infective Endocarditis) Registry
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Sengupta, Shantanu P, Prendergast, Bernard, Laroche, Cécile, Furnaz, Shumaila, Ronderos, Ricardo, Almaghraby, Abdallah, Asch, Federico M, Blechova, Kamila, Zaky, Hosam, Strahilevitz, Jacob, Dworakowski, Rafal, Miyasaka, Yoko, Sebag, Igal, Izumi, Chisato, Axler, Olivier, Jamiel, Abdulrahman, Philip, Mary, Campos Vieira, Marcelo Luiz, Lancellotti, Patrizio, Habib, Gilbert, P Gale, C, Beleslin, B, Budaj, A, Chioncel, O, Dagres, N, Danchin, N, Emberson, J, Erlinge, D, Glikson, M, Gray, A, Kayikcioglu, M, P Maggioni, A, K Nagy, V, Nedoshivin, A, A-S, Petronio, Roos-Hesselink, J, Wallentin, L, Zeymer, U, Habib, G, Lancellotti, P, Cosyns, B, Donal, E, Erba, P, Iung, B, A Popescu, B, Prendergast, B, Tornos, P, Andarala, M, Berle, C, Brunel-Lebecq, A, Fiorucci, E, Laroche, C, Missiamenou, V, Taylor, C, N Ali Tatar-Chentir, N, Al-Mallah, M, M Astrom Aneq, Athanassopoulos, G, P Badano, L, Benyoussef, S, E Calderon Aranda, M Cardim, N, K-L, Chan, Cruz, I, Edvardsen, T, Goliasch, G, Hagendorff, A, 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Chandrasekaran, B, Kopanska, A, Chambers, J, Hancock, J, Klein, J, Rajani, R, Ursi, M, Cannata, S, Fife, A, Breeze, J, Browne-Morgan, M, Gunning, M, Streather, S, Zemedkun, M, Alyavi, B, and Uzokov, J
- Subjects
Socioeconomic ,[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases ,Endocarditis ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Health Policy ,[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology ,Socio-economic ,[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology ,Endocarditi ,Cardiology and Cardiovascular Medicine ,[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology - Abstract
Aims Infective endocarditis (IE) is a life-threatening disease associated with high mortality and morbidity worldwide. We sought to determine how socioeconomic factors might influence its epidemiology, clinical presentation, investigation and management, and outcome, in a large international multicentre registry. Methods and results The EurObservational Programme (EORP) of the European Society of Cardiology EURO-ENDO (European Infective Endocarditis) registry comprises a prospective cohort of 3113 adult patients admitted for IE in 156 hospitals in 40 countries between January 2016 and March 2018. Patients were separated in three groups, according to World Bank economic stratification [group 1: high income (75.6%); group 2: upper-middle income (15.4%); group 3: lower-middle income (9.1%)]. Group 3 patients were younger [median age (interquartile range, IQR): group 1, 66 (53–75) years; group 2, 57 (41–68) years; group 3, 33 (26–43) years; P < 0.001] with a higher frequency of smokers, intravenous drug use, and human immunodeficiency virus infection (all P < 0.001) and presented later [median (IQR) days since symptom onset: group 1, 12 (3–35); group 2, 19 (6–54); group 3, 31 (12–62); P < 0.001] with a higher likelihood of developing congestive heart failure (13.6%, 11.1%, and 22.6%, respectively; P < 0.001) and persistent fever (9.8%, 14.2%, and 27.9%, respectively; P < 0.001). Among 2157 (69.3%) patients with theoretical indication for cardiac surgery, surgery was performed less frequently in group 3 patients (75.5%, 76.8%, and 51.3%, respectively; P < 0.001), who also demonstrated the highest mortality (15.0%, 23.0%, and 23.7%, respectively; P < 0.001). Conclusion Socioeconomic factors influence the clinical profile of patients presenting with IE across the world. Despite younger age, patients from the poorest countries presented with more frequent complications and higher mortality associated with delayed diagnosis and lower use of surgery.
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- 2022
8. Cardiac rupture after ST elevation myocardial infarction – a decade's experience of a tertiary cardiology centre
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Margineanu, C, primary, Antohi, E L, additional, Bubenek, S, additional, Carp, A, additional, Deleanu, D, additional, Filipescu, D, additional, Filipescu, R, additional, Geavlete, O D, additional, Iliescu, V, additional, Radulescu, B, additional, Stiru, O, additional, Stoica, E, additional, and Chioncel, O, additional
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- 2022
- Full Text
- View/download PDF
9. Pathophysiology of Takotsubo syndrome – a joint scientific statement from the Heart Failure Association Takotsubo Syndrome Study Group and Myocardial Function Working Group of the European Society of Cardiology – Part 2: vascular pathophysiology, gender and sex hormones, genetics, chronic cardiovascular problems and clinical implications
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Omerovic, E, Citro, R, Bossone, E, Redfors, B, Backs, J, Bruns, B, Ciccarelli, M, Couch, L, Dawson, D, Grassi, G, Iacoviello, M, Parodi, G, Schneider, B, Templin, C, Ghadri, J, Thum, T, Chioncel, O, Tocchetti, C, Van Der Velden, J, Heymans, S, Lyon, A, Omerovic E., Citro R., Bossone E., Redfors B., Backs J., Bruns B., Ciccarelli M., Couch L. S., Dawson D., Grassi G., Iacoviello M., Parodi G., Schneider B., Templin C., Ghadri J. R., Thum T., Chioncel O., Tocchetti C. G., Van Der Velden J., Heymans S., Lyon A. R., Omerovic, E, Citro, R, Bossone, E, Redfors, B, Backs, J, Bruns, B, Ciccarelli, M, Couch, L, Dawson, D, Grassi, G, Iacoviello, M, Parodi, G, Schneider, B, Templin, C, Ghadri, J, Thum, T, Chioncel, O, Tocchetti, C, Van Der Velden, J, Heymans, S, Lyon, A, Omerovic E., Citro R., Bossone E., Redfors B., Backs J., Bruns B., Ciccarelli M., Couch L. S., Dawson D., Grassi G., Iacoviello M., Parodi G., Schneider B., Templin C., Ghadri J. R., Thum T., Chioncel O., Tocchetti C. G., Van Der Velden J., Heymans S., and Lyon A. R.
- Abstract
While the first part of the scientific statement on the pathophysiology of Takotsubo syndrome was focused on catecholamines and the sympathetic nervous system, in the second part we focus on the vascular pathophysiology including coronary and systemic vascular responses, the role of the central and peripheral nervous systems during the acute phase and abnormalities in the subacute phase, the gender differences and integrated effects of sex hormones, genetics of Takotsubo syndrome including insights from microRNA studies and inducible pluripotent stem cell models of Takotsubo syndrome. We then discuss the chronic abnormalities of cardiovascular physiology in survivors, the limitations of current clinical and preclinical studies, the implications of the knowledge of pathophysiology for clinical management and future perspectives and directions of research.
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- 2021
10. COVID-19 vaccination in patients with heart failure: a position paper of the Heart Failure Association of the European Society of Cardiology
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Rosano, G, Jankowska, E, Ray, R, Metra, M, Abdelhamid, M, Adamopoulos, S, Anker, S, Bayes-Genis, A, Belenkov, Y, Gal, T, Böhm, M, Chioncel, O, Cohen-Solal, A, Farmakis, D, Filippatos, G, González, A, Gustafsson, F, Hill, L, Jaarsma, T, Jouhra, F, Lainscak, M, Lambrinou, E, Lopatin, Y, Lund, L, Milicic, D, Moura, B, Mullens, W, Piepoli, M, Ponikowski, P, Rakisheva, A, Ristic, A, Savarese, G, Seferovic, P, Senni, M, Thum, T, Tocchetti, C, Van Linthout, S, Volterrani, M, Coats, A, Rosano G, Jankowska EA, Ray R, Metra M, Abdelhamid M, Adamopoulos S, Anker SD, Bayes-Genis A, Belenkov Y, Gal TB, Böhm M, Chioncel O, Cohen-Solal A, Farmakis D, Filippatos G, González A, Gustafsson F, Hill L, Jaarsma T, Jouhra F, Lainscak M, Lambrinou E, Lopatin Y, Lund LH, Milicic D, Moura B, Mullens W, Piepoli MF, Ponikowski P, Rakisheva A, Ristic A, Savarese G, Seferovic P, Senni M, Thum T, Tocchetti CG, Van Linthout S, Volterrani M, Coats AJS, Rosano, G, Jankowska, E, Ray, R, Metra, M, Abdelhamid, M, Adamopoulos, S, Anker, S, Bayes-Genis, A, Belenkov, Y, Gal, T, Böhm, M, Chioncel, O, Cohen-Solal, A, Farmakis, D, Filippatos, G, González, A, Gustafsson, F, Hill, L, Jaarsma, T, Jouhra, F, Lainscak, M, Lambrinou, E, Lopatin, Y, Lund, L, Milicic, D, Moura, B, Mullens, W, Piepoli, M, Ponikowski, P, Rakisheva, A, Ristic, A, Savarese, G, Seferovic, P, Senni, M, Thum, T, Tocchetti, C, Van Linthout, S, Volterrani, M, Coats, A, Rosano G, Jankowska EA, Ray R, Metra M, Abdelhamid M, Adamopoulos S, Anker SD, Bayes-Genis A, Belenkov Y, Gal TB, Böhm M, Chioncel O, Cohen-Solal A, Farmakis D, Filippatos G, González A, Gustafsson F, Hill L, Jaarsma T, Jouhra F, Lainscak M, Lambrinou E, Lopatin Y, Lund LH, Milicic D, Moura B, Mullens W, Piepoli MF, Ponikowski P, Rakisheva A, Ristic A, Savarese G, Seferovic P, Senni M, Thum T, Tocchetti CG, Van Linthout S, Volterrani M, and Coats AJS
- Abstract
Patients with heart failure (HF) who contract SARS-CoV-2 infection are at a higher risk of cardiovascular and non-cardiovascular morbidity and mortality. Regardless of therapeutic attempts in COVID-19, vaccination remains the most promising global approach at present for controlling this disease. There are several concerns and misconceptions regarding the clinical indications, optimal mode of delivery, safety and efficacy of COVID-19 vaccines for patients with HF. This document provides guidance to all healthcare professionals regarding the implementation of a COVID-19 vaccination scheme in patients with HF. COVID-19 vaccination is indicated in all patients with HF, including those who are immunocompromised (e.g. after heart transplantation receiving immunosuppressive therapy) and with frailty syndrome. It is preferable to vaccinate against COVID-19 patients with HF in an optimal clinical state, which would include clinical stability, adequate hydration and nutrition, optimized treatment of HF and other comorbidities (including iron deficiency), but corrective measures should not be allowed to delay vaccination. Patients with HF who have been vaccinated against COVID-19 need to continue precautionary measures, including the use of facemasks, hand hygiene and social distancing. Knowledge on strategies preventing SARS-CoV-2 infection (including the COVID-19 vaccination) should be included in the comprehensive educational programmes delivered to patients with HF.
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- 2021
11. Management of a rare cardiomyopathy presented with congestive heart failure and electrical storm: 86
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Covaliov, A, Radulescu, C, Antohi, L, Ciudin, R, and Chioncel, O
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- 2017
12. Cardiac remodelling – Part 1: From cells and tissues to circulating biomarkers. A review from the Study Group on Biomarkers of the Heart Failure Association of the European Society of Cardiology
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González, A, Richards, AM, de Boer, RA, Thum, T, Arfsten, H, Hülsmann, M, Falcao-Pires, I, Díez, J, Foo, RS, Chan, MYY, Aimo, A, Anene-Nzelu, GC, Abdelhamid, M, Adamopoulos, S, Anker, SD, Belenkov, Y, Gal, TB, Cohen-Solal, A, Böhm, M, Chioncel, O, Delgado, V, Emdin, M, Jankowska, EA, Gustafsson, F, Hill, L, Jaarsma, T, Januzzi, JL, Jhund, PS, Lopatin, Y, Lund, LH, Metra, M, Milicic, D, Moura, B, Mueller, C, Mullens, W, Núñez, J, Piepoli, MF, Rakisheva, A, Ristic, A, Rossignol, P, Savarese, G, Tocchetti, CG, Van Linthout, S, Volterrani, M, Seferovic, P, Rosano, G, Coats, AJ, and Bayes-Genis, A
- Abstract
Cardiac remodelling refers to changes in left ventricular structure and function over time, with a progressive deterioration that may lead to heart failure (HF) development (adverse remodelling) or vice versa a recovery (reverse remodelling) in response to HF treatment. Adverse remodelling predicts a worse outcome, whilst reverse remodelling predicts a better prognosis. The geometry, systolic and diastolic function and electric activity of the left ventricle are affected, as well as the left atrium and on the long term even right heart chambers. At a cellular and molecular level, remodelling involves all components of cardiac tissue: cardiomyocytes, fibroblasts, endothelial cells and leucocytes. The molecular, cellular and histological signatures of remodelling may differ according to the cause and severity of cardiac damage, and clearly to the global trend toward worsening or recovery. These processes cannot be routinely evaluated through endomyocardial biopsies, but may be reflected by circulating levels of several biomarkers. Different classes of biomarkers (e.g. proteins, non-coding RNAs, metabolites and/or epigenetic modifications) and several biomarkers of each class might inform on some aspects on HF development, progression and long-term outcomes, but most have failed to enter clinical practice. This may be due to the biological complexity of remodelling, so that no single biomarker could provide great insight on remodelling when assessed alone. Another possible reason is a still incomplete understanding of the role of biomarkers in the pathophysiology of cardiac remodelling. Such role will be investigated in the first part of this review paper on biomarkers of cardiac remodelling.
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- 2022
13. Cardiac remodelling - Part 2: Clinical, imaging and laboratory findings. A review from the Study Group on Biomarkers of the Heart Failure Association of the European Society of Cardiology
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Aimo, A, Vergaro, G, Gonzalez, A, Barison, A, Lupon, J, Delgado, V, Richards, AM, de Boer, RA, Thum, T, Arfsten, H, Hulsmann, M, Falcao-Pires, I, Diez, J, Foo, RSY, Chan, MYY, Anene-Nzelu, CG, Abdelhamid, M, Adamopoulos, S, Anker, SD, Belenkov, Y, Gal, TB, Cohen-Solal, A, Bohm, M, Chioncel, O, Jankowska, EA, Gustafsson, F, Hill, L, Jaarsma, T, Januzzi, JL, Jhund, P, Lopatin, Y, Lund, LH, Metra, M, Milicic, D, Moura, B, Mueller, C, Mullens, W, Nunez, J, Piepoli, MF, Rakisheva, A, Ristic, AD, Rossignol, P, Savarese, G, Tocchetti, CG, van Linthout, S, Volterrani, M, Seferovic, P, Rosano, G, Coats, AJS, Emdin, M, and Bayes-Genis, A
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Ejection fraction ,Predictors ,Therapies ,Remodelling ,Heart failure ,Biomarkers ,Imaging - Abstract
In patients with heart failure, the beneficial effects of drug and device therapies counteract to some extent ongoing cardiac damage. According to the net balance between these two factors, cardiac geometry and function may improve (reverse remodelling, RR) and even completely normalize (remission), or vice versa progressively deteriorate (adverse remodelling, AR). RR or remission predict a better prognosis, while AR has been associated with worsening clinical status and outcomes. The remodelling process ultimately involves all cardiac chambers, but has been traditionally evaluated in terms of left ventricular volumes and ejection fraction. This is the second part of a review paper by the Study Group on Biomarkers of the Heart Failure Association of the European Society of Cardiology dedicated to ventricular remodelling. This document examines the proposed criteria to diagnose RR and AR, their prevalence and prognostic value, and the variables predicting remodelling in patients managed according to current guidelines. Much attention will be devoted to RR in patients with heart failure with reduced ejection fraction because most studies on cardiac remodelling focused on this setting.
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- 2022
14. Impact analysis of heart failure across European countries: an ESC-HFA position paper
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Rosano, GMC, Seferovic, P, Savarese, G, Spoletini, I, Lopatin, Y, Gustafsson, F, Bayes-Genis, A, Jaarsma, T, Abdelhamid, M, Miqueo, AG, Piepoli, M, Tocchetti, CG, Ristic, AD, Jankowska, E, Moura, B, Hill, L, Filippatos, G, Metra, M, Milicic, D, Thum, T, Chioncel, O, Ben Gal, T, Lund, LH, Farmakis, D, Mullens, W, Adamopoulos, S, Bohm, M, Norhammar, A, Bollmann, A, Banerjee, A, Maggioni, AP, Voors, A, Solal, AC, Coats, AJS, Maggioni, Aldo Pietro/0000-0003-2764-6779, Hill, Loreena/0000-0001-5232-0936, Gustafsson, Finn/0000-0003-2144-341X, Rosano, Giuseppe M. C., Seferovic, Petar, Savarese, Gianluigi, Spoletini, Ilaria, Lopatin, Yuri, Gustafsson, Fin, Bayes-Genis, Antoni, Jaarsma, Tiny, Abdelhamid, Magdy, Miqueo, Arantxa Gonzalez, Piepoli, Massimo, Tocchetti, Carlo G., Ristic, Arsen D., Jankowska, Ewa, Moura, Brenda, Hill, Loreena, Filippatos, Gerasimos, Metra, Marco, Milicic, Davor, Thum, Thomas, Chioncel, Ovidiu, Ben Gal, Tuvia, Lund, Lars H., Farmakis, Dimitrios, MULLENS, Wilfried, Adamopoulos, Stamatis, Bohm, Michael, Norhammar, Anna, Bollmann, Andreas, Banerjee, Amitava, Maggioni, Aldo P., Voors, Adriaan, Solal, Alain Cohen, and Coats, Andrew J. S.
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Quality of life ,Impact ,Epidemiology ,Heart failure ,Mortality ,Morbidity ,Prognosis - Abstract
Heart failure (HF) is a long-term clinical syndrome, with increasing prevalence and considerable healthcare costs that are further expected to increase dramatically. Despite significant advances in therapy and prevention, mortality and morbidity remain high and quality of life poor. Epidemiological data, that is, prevalence, incidence, mortality, and morbidity, show geographical variations across the European countries, depending on differences in aetiology, clinical characteristics, and treatment. However, data on the prevalence of the disease are scarce, as are those on quality of life. For these reasons, the ESC-HFA has developed a position paper to comprehensively assess our understanding of the burden of HF in Europe, in order to guide future policies for this syndrome. This manuscript will discuss the available epidemiological data on HF prevalence, outcomes, and human costs-in terms of quality of life-in European countries.
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- 2022
15. Evaluation of the effect of intravenous nitroglycerine on short-term survival of patients with acute heart failure according to congestion and perfusion status at emergency department arrival
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Miró Ò, Espinosa B, Gil V, Jacob J, Alquézar-Arbé A, Masip J, Llauger L, Tost J, Andueza JA, Garrido JM, Mojarro EM, Urbano CA, Núñez J, Chioncel O, Mullens W, Cotter G, and Llorens P
- Abstract
We investigated if the phenotypic classification of acute heart failure (AHF) based on the number of signs/symptoms of congestion and hypoperfusion at emergency department (ED) arrival identifies subgroups in which intravenous (IV) nitroglycerine (NTG) use improves short-term survival. We included consecutive AHF patients diagnosed in 45 Spanish EDs, who were grouped according to phenotype severity. The main outcome was 30-day all-cause death. Propensity scores (PS) for NTG use were generated using variables associated with death. Analysis of interaction was performed in subgroups of patients based on congestion, hypoperfusion, age, sex, coronary artery disease (CAD), left ventricular ejection fraction (LVEF) and SBP. We analyzed 16 437 AHF patients (median = 83 years; women = 56%); 1882 received NTG (11.4%). In the whole cohort, the cumulative 30-day mortality in patients receiving NTG was higher (11.5% vs. 9.6%; unadjusted HR, 1.19; 95% CI, 1.04-1.36), but not in the PS-matched cohorts (1698 pairs of patients; 11.5% vs. 10.5%; HR, 1.10; 95% CI, 0.90-1.35). Mortality was increased in NTG-treated patients with mild congestion (HR, 2.09; 95% CI, 1.19-3.67), especially in those without hypoperfusion (HR, 2.51; 95% CI, 1.24-5.10). Interaction analysis of the PS-matched cohorts confirmed detrimental effects of NTG use in less congested patients, whereas beneficial effects were only observed in patients with decreased LVEF (
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- 2022
16. Linee guida ESC 2021 per la diagnosi e il trattamento dello scompenso cardiaco acuto e cronico elaborate dalla Task Force per la diagnosi e il trattamento dello scompenso cardiaco acuto e cronico della Società Europea di Cardiologia (ESC) con il contributo straordinario della Heart Failure Association (HFA) dell’ESC = [2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). With the special contribution of the Heart Failure Association (HFA) of the ESC]
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Mcdonagh, T.A., Metra, M., Adamo, M., Gardner, R.S., Baumbach, A., Boehm, M., Burri, H., Butler, J., Celutkiene, J., Chioncel, O., Cleland, J.G.F., Coats, A.J.S., Crespo-Leiro, M.G., Farmakis, D., Gilard, M., Heymans, S., Hoes, A.W., Jaarsma, T., Jankowska, E.A., Lainscak, M., Lam, C.S.P., Lyon, A.R., Mcmurray, John, J., V, Mebazaa, A., Mindham, R., Muneretto, C., Piepoli, M.F., Price, S., Rosano, G.M.C., Ruschitzka, F., and Skibelund, A.K.
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Settore MED/11 - Malattie dell'Apparato Cardiovascolare - Published
- 2022
17. Clinical presentation, aetiology and outcome of infective endocarditis. Results of the ESC-EORP EURO-ENDO (European infective endocarditis) registry: A prospective cohort study
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Habib, G, Erba, P, Iung, B, Donal, E, Cosyns, B, Laroche, C, Popescu, B, Prendergast, B, Tornos, P, Sadeghpour, A, Oliver, L, Vaskelyte, J, Sow, R, Axler, O, Maggioni, A, Lancellotti, P, Gale, C, Beleslin, B, Budaj, A, Chioncel, O, Dagres, N, Danchin, N, Emberson, J, Erlinge, D, Glikson, M, Gray, A, Kayikcioglu, M, Nagy, V, Nedoshivin, A, Petronio, A, Roos-Hesselink, J, Wallentin, L, Zeymer, U, Andarala, M, Berle, C, Brunel-Lebecq, A, Fiorucci, E, Missiamenou, V, Taylor, C, Ali Tatar-Chentir, N, Al-Mallah, M, Astrom Aneq, M, Athanassopoulos, G, Badano, L, Benyoussef, S, Calderon Aranda, E, Cardim, N, Chan, K, Cruz, I, Edvardsen, T, Goliasch, G, Hagendorff, A, Hristova, K, Kamp, O, Kang, D, Kong, W, Matskeplishvili, S, Meshaal, M, Mirocevic, M, Neskovic, A, Pazdernik, M, Plonska-Gosciniak, E, Raissouni, M, Ronderos, R, Sade, L, Sambola, A, Sengupta, S, Separovic-Hanzevacki, J, Takeuchi, M, Tucay, E, Tude Rodrigues, A, Varga, A, Yamagata, K, Yiangou, K, Zaky, H, Granada, I, Mahia, M, Ressi, S, Nacinovich, F, Iribarren, A, Fernandez Oses, P, Avegliano, G, Filipini, E, Obregon, R, Bangher, M, Dho, J, Cartasegna, L, Plastino, M, Novas, V, Shigel, C, Reyes, G, De Santos, M, Gastaldello, N, Granillo Fernandez, M, Potito, M, Streitenberger, G, Velazco, P, Casabe, J, Cortes, C, Guevara, E, Salmo, F, Seijo, M, Weidinger, F, Heger, M, Brooks, R, Stollberger, C, Ho, C, Perschy, L, Puskas, L, Binder, C, Rosenhek, R, Schneider, M, Winter, M, Hoffer, E, Melissopoulou, M, Lecoq, E, Legrand, D, Jacquet, S, Massoz, M, Pierard, L, Marchetta, S, Dulgheru, R, Emal, C, Oury, C, Droogmans, S, Kerkhove, D, Plein, D, Soens, L, Weytjens, C, Motoc, A, Roosens, B, Lemoine, I, Rodrigus, I, Paelinck, B, Amsel, B, Unger, P, Konopnicki, D, Beauloye, C, Pasquet, A, Vanoverschelde, J, Pierard, S, Vancraeynest, D, Sinnaeve, F, Andrade, J, Staszko, K, Dos Santos Monteiro, R, Miglioranza, M, Shuha, D, Alcantara, M, Cravo, V, Fazzio, L, Felix, A, Iso, M, Musa, C, Siciliano, A, Villaca Filho, F, Rodrigues, A, Vilela, F, Braga, J, Silva, R, Rodrigues, D, Silva, L, Morhy, S, Fischer, C, Vieira, M, Afonso, T, Abreu, J, Falcao, S, Moises, V, Gouvea, A, Mancuso, F, Souza, A, Silva, C, Joao, G, Abboud, C, Bellio de Mattos Barretto, R, Ramos, A, Arnoni, R, Assef, J, Della Togna, D, Le Bihan, D, Miglioli, L, Romero Oliveira, A, Tadeu Magro Kroll, R, Cortez, D, Gelape, C, Peirira Nunes, M, De Abreu Ferrari, T, Hay, K, Le, V, Page, M, Poulin, F, Sauve, C, Serri, K, Mercure, C, Beaudoin, J, Pibarot, P, Sebag, I, Rudski, L, Ricafort, G, Barsic, B, Krajinovic, V, Vargovic, M, Lovric, D, Reskovic-Luksic, V, Vincelj, J, Jaksic Jurinjak, S, Yiannikourides, V, Ioannides, M, Pofaides, C, Masoura, V, Pudich, J, Linhart, A, Siranec, M, Marek, J, Blechova, K, Kamenik, M, Pelouch, R, Coufal, Z, Mikulica, M, Griva, M, Jancova, E, Mikulcova, M, Taborsky, M, Precek, J, Jecmenova, M, Latal, J, Widimsky, J, Butta, T, Machacek, S, Vancata, R, Spinar, J, Holicka, M, Pow Chon Long, F, Anzules, N, Bajana Carpio, A, Largacha, G, Penaherrera, E, Moreira, D, Mahfouz, E, Elsafty, E, Soliman, A, Zayed, Y, Aboulenein, J, Abdel-Hay, M, Almaghraby, A, Abdelnaby, M, Ahmed, M, Hammad, B, Saleh, Y, Zahran, H, Elgebaly, O, Saad, A, Ali, M, Zeid, A, El Sharkawy, R, Al Kholy, A, Doss, R, Osama, D, Rizk, H, Elmogy, A, Mishriky, M, Assayag, P, El Hatimi, S, Hubert, S, Casalta, J, Gouriet, F, Arregle, F, Cammilleri, S, Tessonnier, L, Riberi, A, Botelho-Nevers, E, Gagneux-Brunon, A, Pierrard, R, Tulane, C, Campisi, S, Fuzellier, J, Detoc, M, Mehalla, T, Boutoille, D, Lecompte, A, Lefebvre, M, Pattier, S, Al Habash, O, Asseray-Madani, N, Biron, C, Brochard, J, Caillon, J, Cueff, C, Le Tourneau, T, Lecomte, R, Magali Michel, M, Orain, J, Delarue, S, Le Bras, M, Faucher, J, Aboyans, V, Beeharry, A, Durox, H, Lacoste, M, Magne, J, Mohty, D, David, A, Pradel, V, Sierra, V, Neykova, A, Bettayeb, B, Elkentaoui, S, Tzvetkov, B, Landry, G, Strady, C, Ainine, K, Baumard, S, Brasselet, C, Tassigny, C, Valente-Pires, V, Lefranc, M, Hoen, B, Lefevre, B, Curlier, E, Callier, C, Fourcade, N, Jobic, Y, Ansard, S, Le Berre, R, Le Ven, F, Pouliquen, M, Prat, G, Le Roux, P, Bouchart, F, Savoure, A, Alarcon, C, Chapuzet, C, Gueit, I, Tribouilloy, C, Bohbot, Y, Peugnet, F, Gun, M, Duval, X, Lescure, X, Ilic-Habensus, E, Sadoul, N, Selton-Suty, C, Alla, F, Goehringer, F, Huttin, O, Chevalier, E, Garcia, R, Le Marcis, V, Tattevin, P, Flecher, E, Revest, M, Chirouze, C, Bouiller, K, Hustache-Mathieu, L, Klopfenstein, T, Moreau, J, Fournier, D, Brunel, A, Lim, P, Ternacle, J, Moussafeur, A, Chavanet, P, Piroth, L, Salmon-Rousseau, A, Buisson, M, Mahy, S, Martins, C, Gohier, S, Baumann, F, Lebras, S, Piper, C, Guckel, D, Borgermann, J, Horstkotte, D, Winkelmann, E, Brockmeier, B, Grey, D, Nickenig, G, Schueler, R, Ozturk, C, Stohr, E, Hamm, C, Walther, T, Brandt, R, Fruhauf, A, Hartung, C, Hellner, C, Wild, C, Becker, M, Hamada, S, Kaestner, W, Stangl, K, Knebel, F, Baldenhofer, G, Brecht, A, Dreger, H, Isner, C, Pfafflin, F, Stegemann, M, Zahn, R, Fraiture, B, Kilkowski, C, Karcher, A, Klinger, S, Tolksdorf, H, Tousoulis, D, Aggeli, C, Sideris, S, Venieri, E, Sarri, G, Tsiapras, D, Armenis, I, Koutsiari, A, Floros, G, Grassos, C, Dragasis, S, Rallidis, L, Varlamos, C, Michalis, L, Naka, K, Bechlioulis, A, Kotsia, A, Lakkas, L, Pappas, K, Papadopoulos, C, Kiokas, S, Lioni, A, Misailidou, S, Barbetseas, J, Bonou, M, Kapelios, C, Tomprou, I, Zerva, K, Manolis, A, Hamodraka, E, Athanasiou, D, Haralambidis, G, Samaras, H, Poulimenos, L, Nagy, A, Bartykowszki, A, Gara, E, Mungulmare, K, Kasliwal, R, Bansal, M, Ranjan, S, Bhan, A, Kyavar, M, Maleki, M, Noohi Bezanjani, F, Alizadehasl, A, Boudagh, S, Ghavidel, A, Moradnejad, P, Pasha, H, Ghadrdoost, B, Gilon, D, Strahilevitz, J, Wanounou, M, Israel, S, D'Agostino, C, Colonna, P, De Michele, L, Fumarola, F, Stante, M, Marchionni, N, Scheggi, V, Alterini, B, Del Pace, S, Stefano, P, Sparano, C, Ruozi, N, Tenaglia, R, Muraru, D, 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C., Varga A., Yamagata K., Yiangou K., Zaky H., Granada I., Mahia M., Ressi S., Nacinovich F., Iribarren A., Fernandez Oses P., Avegliano G., Filipini E., Obregon R., Bangher M., Dho J., Cartasegna L., Plastino M. L., Novas V., Shigel C., Reyes G., De Santos M., Gastaldello N., Granillo Fernandez M., Potito M., Streitenberger G., Velazco P., Casabe J. H., Cortes C., Guevara E., Salmo F., Seijo M., Weidinger F., Heger M., Brooks R., Stollberger C., Ho C. Y., Perschy L., Puskas L., Binder C., Rosenhek R., Schneider M., Winter M. P., Hoffer E., Melissopoulou M., Lecoq E., Legrand D., Jacquet S., Massoz M., Pierard L., Marchetta S., Dulgheru R., Emal C. D., Oury C., Droogmans S., Kerkhove D., Plein D., Soens L., Weytjens C., Motoc A., Roosens B., Lemoine I., Rodrigus I., Paelinck B., Amsel B., Unger P., Konopnicki D., Beauloye C., Pasquet A., Vanoverschelde J. L., Pierard S., Vancraeynest D., Sinnaeve F., Andrade J. L., Staszko K., Dos Santos Monteiro R., Miglioranza M. H., Shuha D. L., Alcantara M., Cravo V., Fazzio L., Felix A., Iso M., Musa C., Siciliano A. P., Villaca Filho F., Rodrigues A., Vilela F., Braga J., Silva R., Rodrigues D., Silva L., Morhy S., Fischer C., Vieira M., Afonso T., Abreu J., Falcao S. N., Moises V. A., Gouvea A., Mancuso F. J., Souza A. C., Silva C. Y., Joao G., Abboud C. S., Bellio de Mattos Barretto R., Ramos A., Arnoni R., Assef J. E., Della Togna D. J., Le Bihan D., Miglioli L., Romero Oliveira A. P., Tadeu Magro Kroll R., Cortez D., Gelape C. L., Peirira Nunes MDC., De Abreu Ferrari T. C., Hay K., Le V., Page M., Poulin F., Sauve C., Serri K., Mercure C., Beaudoin J., Pibarot P., Sebag I. A., Rudski L. G., Ricafort G., Barsic B., Krajinovic V., Vargovic M., Lovric D., Reskovic-Luksic V., Vincelj J., Jaksic Jurinjak S., Yiannikourides V., Ioannides M., Pofaides C., Masoura V., Pudich J., Linhart A., Siranec M., Marek J., Blechova K., Kamenik M., Pelouch R., Coufal Z., Mikulica M., Griva M., Jancova E., Mikulcova M., Taborsky M., Precek J., Jecmenova M., Latal J., Widimsky J., Butta T., Machacek S., Vancata R., Spinar J., Holicka M., Pow Chon Long F., Anzules N., Bajana Carpio A., Largacha G., Penaherrera E., Moreira D., Mahfouz E., Elsafty E., Soliman A., Zayed Y., Aboulenein J., Abdel-Hay M., Almaghraby A., Abdelnaby M., Ahmed M., Hammad B., Saleh Y., Zahran H., Elgebaly O., Saad A., Ali M., Zeid A., El Sharkawy R., Al Kholy A., Doss R., Osama D., Rizk H., Elmogy A., Mishriky M., Assayag P., El Hatimi S., Hubert S., Casalta J. P., Gouriet F., Arregle F., Cammilleri S., Tessonnier L., Riberi A., Botelho-Nevers E., Gagneux-Brunon A., Pierrard R., Tulane C., Campisi S., Fuzellier J. F., Detoc M., Mehalla T., Boutoille D., Lecompte A. S., Lefebvre M., Pattier S., Al Habash O., Asseray-Madani N., Biron C., Brochard J., Caillon J., Cueff C., Le Tourneau T., Lecomte R., Magali Michel M. M., Orain J., Delarue S., Le Bras M., Faucher J. F., Aboyans V., Beeharry A., Durox H., Lacoste M., Magne J., Mohty D., David A., Pradel V., Sierra V., Neykova A., Bettayeb B., Elkentaoui S., Tzvetkov B., Landry G., Strady C., Ainine K., Baumard S., Brasselet C., Tassigny C., Valente-Pires V., Lefranc M., Hoen B., Lefevre B., Curlier E., Callier C., Fourcade N., Jobic Y., Ansard S., Le Berre R., Le Ven F., Pouliquen M. C., Prat G., Le Roux P., Bouchart F., Savoure A., Alarcon C., Chapuzet C., Gueit I., Tribouilloy C., Bohbot Y., Peugnet F., Gun M., Duval X., Lescure X., Ilic-Habensus E., Sadoul N., Selton-Suty C., Alla F., Goehringer F., Huttin O., Chevalier E., Garcia R., Le Marcis V., Tattevin P., Flecher E., Revest M., Chirouze C., Bouiller K., Hustache-Mathieu L., Klopfenstein T., Moreau J., Fournier D., Brunel A. S., Lim P., Ternacle J., Moussafeur A., Chavanet P., Piroth L., Salmon-Rousseau A., Buisson M., Mahy S., Martins C., Gohier S., Baumann F., Lebras S., Piper C., Guckel D., Borgermann J., Horstkotte D., Winkelmann E., Brockmeier B., Grey D., Nickenig G., Schueler R., Ozturk C., Stohr E., Hamm C., Walther T., Brandt R., Fruhauf A. C., Hartung C. T., Hellner C., Wild C., Becker M., Hamada S., Kaestner W., Stangl K., Knebel F., Baldenhofer G., Brecht A., Dreger H., Isner C., Pfafflin F., Stegemann M., Zahn R., Fraiture B., Kilkowski C., Karcher A. K., Klinger S., Tolksdorf H., Tousoulis D., Aggeli C., Sideris S., Venieri E., Sarri G., Tsiapras D., Armenis I., Koutsiari A., Floros G., Grassos C., Dragasis S., Rallidis L., Varlamos C., Michalis L., Naka K., Bechlioulis A., Kotsia A., Lakkas L., Pappas K., Papadopoulos C., Kiokas S., Lioni A., Misailidou S., Barbetseas J., Bonou M., Kapelios C., Tomprou I., Zerva K., Manolis A., Hamodraka E., Athanasiou D., Haralambidis G., Samaras H., Poulimenos L., Nagy A., Bartykowszki A., Gara E., Mungulmare K., Kasliwal R., Bansal M., Ranjan S., Bhan A., Kyavar M., Maleki M., Noohi Bezanjani F., Alizadehasl A., Boudagh S., Ghavidel A., Moradnejad P., Pasha H. R., Ghadrdoost B., Gilon D., Strahilevitz J., Wanounou M., Israel S., d'Agostino C., Colonna P., De Michele L., Fumarola F., Stante M., Marchionni N., Scheggi V., Alterini B., Del Pace S., Stefano P., Sparano C., Ruozi N., Tenaglia R., Muraru D., Limbruno U., Cresti A., Baratta P., Solari M., Giannattasio C., Moreo A., De Chiara B., Lopez Montero B., Musca F., Orcese C. A., Panzeri F., Spano F., Russo C. F., Alfieri O., De Bonis M., Chiappetta S., Del Forno B., Ripa M., Scarpellini P., Tassan Din C., Castiglioni B., Pasciuta R., Carletti S., Ferrara D., Guffanti M., Iaci G., Lapenna E., Nisi T., Oltolini C., Busnardo E., Pajoro U., Agricola E., Meneghin R., Schiavi D., Piscione F., Citro R., Benvenga R. M., Greco L., Soriente L., Radano I., Prota C., Bellino M., Di Vece D., Santini F., Salsano A., Olivieri G. M., Turrini F., Messora R., Tondi S., Olaru A., Agnoletto V., Grassi L., Leonardi C., Sansoni S., Del Ponte S., Actis Dato G. M., De Martino A., Ohte N., Kikuchi S., Wakami K., Aonuma K., Seo Y., Ishizu T., Machino-Ohtsuka T., Yamamoto M., Iida N., Nakajima H., Nakagawa Y., Izumi C., Amano M., Miyake M., Takahashi K., Shiojima I., Miyasaka Y., Maeba H., Suwa Y., Taniguchi N., Tsujimoto S., Kitai T., Ota M., Yuda S., Sasaki S., Hagiwara N., Yamazaki K., Ashihara K., Arai K., Saitou C., Saitou S., Suzuki G., Shibata Y., Watanabe N., Nishino S., Ashikaga K., Kuriyama N., Mahara K., Okubo T., Fujimaki H., Shitan H., Yamamoto H., Abe K., Terada M., Takanashi S., Sata M., Yamada H., Kusunose K., Saijo Y., Seno H., Yuichiro O., Onishi T., Sera F., Nakatani S., Mizuno H., Sengoku K., Park S. W., Eun Kyoung K., Ga Yeon L., Hwang J. W., Jin-Oh C., Park S. J., Sang-Chol L., Sung-A C., Jang S. Y., Heo R., Lee S., Song J. M., Jung E., Plisiene J., Dambrauskaite A., Gruodyte G., Jonkaitiene R., Mizariene V., Atkocaityte J., Zvirblyte R., Codreanu A., Staub T., Michaux C., De la Vega ECL., Jacobs-Orazi L., Mallia Azzopardi C., Xuereb R. G., Piscopo T., Farrugia J., Fenech M., Pllaha E., Vella C., Borg D., Casha R., Grib L., Raevschi E., Grejdieru A., Kravcenco D., Prisacari E., Samohvalov E., Samohvalov S., Sceglova N., Panfile E., Cardaniuc L., Corcea V., Feodorovici A., Gaina V., Girbu L., Jimbei P., Balan G., Cardaniuc I., Benesco I., Marian V., Sumarga N., Bozovic B., Bulatovic N., Lakovic P., Music L., Budde R., Wahadat A., Gamela T., Meijers T., Van Melle J. P., Deursen V. M., Crijns H. J., Bekkers S. C., Cheriex E. C., Gilbers M., Kietselaer B. L., Knackstedt C., Lorusso R., Schalla S., Streukens S. A., Chamuleau S., Cramer M. J., Teske A., Van der Spoel T., Wind A., Lokhorst J., Liesbek O., Van Heusden H., Tanis W., Van der Bilt I., Vriend J., De Lange-van Bruggen H., Karijodikoro E., Riezebos R., van Dongen E., Schoep J., Stolk V., Offstad J. T., Beitnes J. O., Helle-Valle T., Skulstad H., Skardal R., Qamar N., Furnaz S., Ahmed B., Butt M. H., Khanzada M. F., Saghir T., Wahid A., Hryniewiecki T., Szymanski P., Marzec K., Misztal-Ogonowska M., Kosmala W., Przewlocka-Kosmala M., Rojek A., Woznicka K., Zachwyc J., Lisowska A., Kaminska M., Kasprzak J. D., Kowalczyk E., Strzecka D. F., Wejner-Mik P., Trabulo M., Freitas P., Ranchordas S., Rodrigues G., Pinto P., Queiros C., Azevedo J., Marques L., Seabra D., Branco L., Cruz M., Galrinho A., Moreira R., Rio P., Timoteo A. T., Selas M., Carmelo V., Duque Neves B., Pereira H., Guerra A., Marques A., Pintassilgo I., Tomescu M. C., Trofenciuc N. M., Andor M., Bordejevic A., Branea H. S., Caruntu F., Velcean L. A., Mavrea A., Onel M. F., Parvanescu T., Pop D., Pop-Moldovan A. L., Puticiu M. I., Cirin L., Citu I. M., Cotoraci C. A., Darabantiu D., Farcas R., Marincu I., Ionac A., Cozma D., Mornos C., Goanta F., Popescu I., Beyer R., Mada R., Rancea R., Tomoaia R., Rosianu H., Stanescu C., Kobalava Z., Karaulova J., Kotova E., Milto A., Pisaryuk A., Povalyaev N., Sorokina M., Alrahimi J., Elshiekh A., Jamiel A., Ahmed A., Attia N., Putnikovic B., Dimic A., Ivanovic B., Matic S., Trifunovic D., Petrovic J., Kosevic D., Stojanovic I., Petrovic I., Dabic P., Milojevic P., Srdanovic I., Susak S., Velicki L., Vulin A., Kovacevic M., Redzek A., Stefanovic M., Yeo T. C., Kong W. K., Poh K. K., Vilacosta I., Ferrera C., Olmos C., Abd El-Nasser M., Calvo Iglesias F., Blanco-Gonzalez E., Bravo Amaro M., Lopez-Rodriguez E., Lugo Adan J., Germinas A. N., Pazos-Lopez P., Pereira Loureiro M., Perez M. T., Raposeiras-Roubin S., Rasheed Yas S., Suarez-Varela M. M., Vasallo Vidal F., Garcia-Dorado D., Fernandez-Hidalgo N., Gonzalez-Alujas T., Lozano J., Maisterra O., Pizzi N., Rios R., Bayes-Genis A., Pedro Botet L., Vallejo N., Llibre C., Mateu L., Nunez R., Quesada D., Berastegui E., Bosch Portell D., Aboal Vinas J., Albert Bertran X., Brugada Tarradellas R., Loma-Osorio Ricon P., Tiron de Llano C., Arnau M. A., Bel A., Blanes M., Osa A., Anguita M., Carrasco F., Castillo J. C., Zamorano J. L., Moya Mur J. L., Alvaro M., Fernandez-Golfin C., Monteagudo J. M., Navas Elorza E., Farinas Alvarez M. C., Aguero Balbin J., Zarauza J., Gutierrez-Diez J. F., Arminanzas C., Arnaiz de Las Revillas F., Arnaiz Garcia A., Cobo Belaustegui M., Fernandez Sampedro M., Gutierrez Cuadra M., Garcia Cuello L., Gonzalez Rico C., Rodriguez-Alvarez R., Goikoetxea J., Montejo M., Miro J. M., Almela M., Ambrosioni J., Moreno A., Quintana E., Sandoval E., Tellez A., Tolosana J. M., Vidal B., Falces C., Fuster D., Garcia-de-la-Maria C., Hernandez-Meneses M., Llopis J., Marco F., Ruiz-Zamora I., Bardaji Ruiz A., Sanz Girgas E., Garcia-Pardo G., Guillen Marzo M., Rodriguez Oviedo A., Villares Jimenez A., Abid L., Hammami R., Kammoun S., Mourali M. S., Ben Hlima M., Boudiche S., Ouali S., Zakhama L., Antit S., Slama I., Gulel O., Sahin M., Karacaglar E., Kucukoglu S., Cetinarslan O., Yasar U. S., Canpolat U., Mutlu B., Atas H., Dervishova R., Ileri C., Alhashmi J., Tahir J., Zarger P., Baslib F., Woldman S., Menezes L., Primus C., Uppal R., Bvekerwa I., Chandrasekaran B., Kopanska A., Chambers J., Hancock J., Klein J., Rajani R., Ursi M. P., Cannata S., Dworakowski R., Fife A., Breeze J., Browne-Morgan M., Gunning M., Streather S., Asch F. M., Zemedkun M., Alyavi B., Uzokov J., Habib, G, Erba, P, Iung, B, Donal, E, Cosyns, B, Laroche, C, Popescu, B, Prendergast, B, Tornos, P, Sadeghpour, A, Oliver, L, Vaskelyte, J, Sow, R, Axler, O, Maggioni, A, Lancellotti, P, Gale, C, Beleslin, B, Budaj, A, Chioncel, O, Dagres, N, Danchin, N, Emberson, J, Erlinge, D, Glikson, M, Gray, A, Kayikcioglu, M, Nagy, V, Nedoshivin, A, Petronio, A, Roos-Hesselink, J, Wallentin, L, Zeymer, U, Andarala, M, Berle, C, Brunel-Lebecq, A, Fiorucci, E, Missiamenou, V, Taylor, C, Ali Tatar-Chentir, N, Al-Mallah, M, Astrom Aneq, M, Athanassopoulos, G, Badano, L, Benyoussef, S, Calderon Aranda, E, Cardim, N, Chan, K, Cruz, I, Edvardsen, T, Goliasch, G, Hagendorff, A, Hristova, K, Kamp, O, Kang, D, Kong, W, Matskeplishvili, S, Meshaal, M, Mirocevic, M, Neskovic, A, Pazdernik, M, Plonska-Gosciniak, E, Raissouni, M, Ronderos, R, Sade, L, Sambola, A, Sengupta, S, Separovic-Hanzevacki, J, Takeuchi, M, Tucay, E, Tude Rodrigues, A, Varga, A, Yamagata, K, 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A., Iung B., Donal E., Cosyns B., Laroche C., Popescu B. A., Prendergast B., Tornos P., Sadeghpour A., Oliver L., Vaskelyte J. -J., Sow R., Axler O., Maggioni A. P., Lancellotti P., Gale C. P., Beleslin B., Budaj A., Chioncel O., Dagres N., Danchin N., Emberson J., Erlinge D., Glikson M., Gray A., Kayikcioglu M., Nagy V. K., Nedoshivin A., Petronio A. S., Roos-Hesselink J., Wallentin L., Zeymer U., Andarala M., Berle C., Brunel-Lebecq A., Fiorucci E., Missiamenou V., Taylor C., Ali Tatar-Chentir N. N., Al-Mallah M., Astrom Aneq M., Athanassopoulos G., Badano L. P., Benyoussef S., Calderon Aranda E., Cardim N. M., Chan K. L., Cruz I., Edvardsen T., Goliasch G., Hagendorff A., Hristova K., Kamp O., Kang D. H., Kong W., Matskeplishvili S., Meshaal M., Mirocevic M., Neskovic A. N., Pazdernik M., Plonska-Gosciniak E., Raissouni M., Ronderos R., Sade L. E., Sambola A., Sengupta S., Separovic-Hanzevacki J., Takeuchi M., Tucay E., Tude Rodrigues A. C., Varga A., Yamagata K., Yiangou K., Zaky H., Granada I., Mahia M., Ressi S., Nacinovich F., Iribarren A., Fernandez Oses P., Avegliano G., Filipini E., Obregon R., Bangher M., Dho J., Cartasegna L., Plastino M. L., Novas V., Shigel C., Reyes G., De Santos M., Gastaldello N., Granillo Fernandez M., Potito M., Streitenberger G., Velazco P., Casabe J. H., Cortes C., Guevara E., Salmo F., Seijo M., Weidinger F., Heger M., Brooks R., Stollberger C., Ho C. Y., Perschy L., Puskas L., Binder C., Rosenhek R., Schneider M., Winter M. P., Hoffer E., Melissopoulou M., Lecoq E., Legrand D., Jacquet S., Massoz M., Pierard L., Marchetta S., Dulgheru R., Emal C. D., Oury C., Droogmans S., Kerkhove D., Plein D., Soens L., Weytjens C., Motoc A., Roosens B., Lemoine I., Rodrigus I., Paelinck B., Amsel B., Unger P., Konopnicki D., Beauloye C., Pasquet A., Vanoverschelde J. L., Pierard S., Vancraeynest D., Sinnaeve F., Andrade J. L., Staszko K., Dos Santos Monteiro R., Miglioranza M. H., Shuha D. L., Alcantara M., Cravo V., Fazzio L., Felix A., Iso M., Musa C., Siciliano A. P., Villaca Filho F., Rodrigues A., Vilela F., Braga J., Silva R., Rodrigues D., Silva L., Morhy S., Fischer C., Vieira M., Afonso T., Abreu J., Falcao S. N., Moises V. A., Gouvea A., Mancuso F. J., Souza A. C., Silva C. Y., Joao G., Abboud C. S., Bellio de Mattos Barretto R., Ramos A., Arnoni R., Assef J. E., Della Togna D. J., Le Bihan D., Miglioli L., Romero Oliveira A. P., Tadeu Magro Kroll R., Cortez D., Gelape C. L., Peirira Nunes MDC., De Abreu Ferrari T. C., Hay K., Le V., Page M., Poulin F., Sauve C., Serri K., Mercure C., Beaudoin J., Pibarot P., Sebag I. A., Rudski L. G., Ricafort G., Barsic B., Krajinovic V., Vargovic M., Lovric D., Reskovic-Luksic V., Vincelj J., Jaksic Jurinjak S., Yiannikourides V., Ioannides M., Pofaides C., Masoura V., Pudich J., Linhart A., Siranec M., Marek J., Blechova K., Kamenik M., Pelouch R., Coufal Z., Mikulica M., Griva M., Jancova E., Mikulcova M., Taborsky M., Precek J., Jecmenova M., Latal J., Widimsky J., Butta T., Machacek S., Vancata R., Spinar J., Holicka M., Pow Chon Long F., Anzules N., Bajana Carpio A., Largacha G., Penaherrera E., Moreira D., Mahfouz E., Elsafty E., Soliman A., Zayed Y., Aboulenein J., Abdel-Hay M., Almaghraby A., Abdelnaby M., Ahmed M., Hammad B., Saleh Y., Zahran H., Elgebaly O., Saad A., Ali M., Zeid A., El Sharkawy R., Al Kholy A., Doss R., Osama D., Rizk H., Elmogy A., Mishriky M., Assayag P., El Hatimi S., Hubert S., Casalta J. P., Gouriet F., Arregle F., Cammilleri S., Tessonnier L., Riberi A., Botelho-Nevers E., Gagneux-Brunon A., Pierrard R., Tulane C., Campisi S., Fuzellier J. F., Detoc M., Mehalla T., Boutoille D., Lecompte A. S., Lefebvre M., Pattier S., Al Habash O., Asseray-Madani N., Biron C., Brochard J., Caillon J., Cueff C., Le Tourneau T., Lecomte R., Magali Michel M. M., Orain J., Delarue S., Le Bras M., Faucher J. F., Aboyans V., Beeharry A., Durox H., Lacoste M., Magne J., Mohty D., David A., Pradel V., Sierra V., Neykova A., Bettayeb B., Elkentaoui S., Tzvetkov B., Landry G., Strady C., Ainine K., Baumard S., Brasselet C., Tassigny C., Valente-Pires V., Lefranc M., Hoen B., Lefevre B., Curlier E., Callier C., Fourcade N., Jobic Y., Ansard S., Le Berre R., Le Ven F., Pouliquen M. C., Prat G., Le Roux P., Bouchart F., Savoure A., Alarcon C., Chapuzet C., Gueit I., Tribouilloy C., Bohbot Y., Peugnet F., Gun M., Duval X., Lescure X., Ilic-Habensus E., Sadoul N., Selton-Suty C., Alla F., Goehringer F., Huttin O., Chevalier E., Garcia R., Le Marcis V., Tattevin P., Flecher E., Revest M., Chirouze C., Bouiller K., Hustache-Mathieu L., Klopfenstein T., Moreau J., Fournier D., Brunel A. S., Lim P., Ternacle J., Moussafeur A., Chavanet P., Piroth L., Salmon-Rousseau A., Buisson M., Mahy S., Martins C., Gohier S., Baumann F., Lebras S., Piper C., Guckel D., Borgermann J., Horstkotte D., Winkelmann E., Brockmeier B., Grey D., Nickenig G., Schueler R., Ozturk C., Stohr E., Hamm C., Walther T., Brandt R., Fruhauf A. C., Hartung C. T., Hellner C., Wild C., Becker M., Hamada S., Kaestner W., Stangl K., Knebel F., Baldenhofer G., Brecht A., Dreger H., Isner C., Pfafflin F., Stegemann M., Zahn R., Fraiture B., Kilkowski C., Karcher A. K., Klinger S., Tolksdorf H., Tousoulis D., Aggeli C., Sideris S., Venieri E., Sarri G., Tsiapras D., Armenis I., Koutsiari A., Floros G., Grassos C., Dragasis S., Rallidis L., Varlamos C., Michalis L., Naka K., Bechlioulis A., Kotsia A., Lakkas L., Pappas K., Papadopoulos C., Kiokas S., Lioni A., Misailidou S., Barbetseas J., Bonou M., Kapelios C., Tomprou I., Zerva K., Manolis A., Hamodraka E., Athanasiou D., Haralambidis G., Samaras H., Poulimenos L., Nagy A., Bartykowszki A., Gara E., Mungulmare K., Kasliwal R., Bansal M., Ranjan S., Bhan A., Kyavar M., Maleki M., Noohi Bezanjani F., Alizadehasl A., Boudagh S., Ghavidel A., Moradnejad P., Pasha H. R., Ghadrdoost B., Gilon D., Strahilevitz J., Wanounou M., Israel S., d'Agostino C., Colonna P., De Michele L., Fumarola F., Stante M., Marchionni N., Scheggi V., Alterini B., Del Pace S., Stefano P., Sparano C., Ruozi N., Tenaglia R., Muraru D., Limbruno U., Cresti A., Baratta P., Solari M., Giannattasio C., Moreo A., De Chiara B., Lopez Montero B., Musca F., Orcese C. A., Panzeri F., Spano F., Russo C. F., Alfieri O., De Bonis M., Chiappetta S., Del Forno B., Ripa M., Scarpellini P., Tassan Din C., Castiglioni B., Pasciuta R., Carletti S., Ferrara D., Guffanti M., Iaci G., Lapenna E., Nisi T., Oltolini C., Busnardo E., Pajoro U., Agricola E., Meneghin R., Schiavi D., Piscione F., Citro R., Benvenga R. M., Greco L., Soriente L., Radano I., Prota C., Bellino M., Di Vece D., Santini F., Salsano A., Olivieri G. M., Turrini F., Messora R., Tondi S., Olaru A., Agnoletto V., Grassi L., Leonardi C., Sansoni S., Del Ponte S., Actis Dato G. M., De Martino A., Ohte N., Kikuchi S., Wakami K., Aonuma K., Seo Y., Ishizu T., Machino-Ohtsuka T., Yamamoto M., Iida N., Nakajima H., Nakagawa Y., Izumi C., Amano M., Miyake M., Takahashi K., Shiojima I., Miyasaka Y., Maeba H., Suwa Y., Taniguchi N., Tsujimoto S., Kitai T., Ota M., Yuda S., Sasaki S., Hagiwara N., Yamazaki K., Ashihara K., Arai K., Saitou C., Saitou S., Suzuki G., Shibata Y., Watanabe N., Nishino S., Ashikaga K., Kuriyama N., Mahara K., Okubo T., Fujimaki H., Shitan H., Yamamoto H., Abe K., Terada M., Takanashi S., Sata M., Yamada H., Kusunose K., Saijo Y., Seno H., Yuichiro O., Onishi T., Sera F., Nakatani S., Mizuno H., Sengoku K., Park S. W., Eun Kyoung K., Ga Yeon L., Hwang J. W., Jin-Oh C., Park S. J., Sang-Chol L., Sung-A C., Jang S. Y., Heo R., Lee S., Song J. M., Jung E., Plisiene J., Dambrauskaite A., Gruodyte G., Jonkaitiene R., Mizariene V., Atkocaityte J., Zvirblyte R., Codreanu A., Staub T., Michaux C., De la Vega ECL., Jacobs-Orazi L., Mallia Azzopardi C., Xuereb R. G., Piscopo T., Farrugia J., Fenech M., Pllaha E., Vella C., Borg D., Casha R., Grib L., Raevschi E., Grejdieru A., Kravcenco D., Prisacari E., Samohvalov E., Samohvalov S., Sceglova N., Panfile E., Cardaniuc L., Corcea V., Feodorovici A., Gaina V., Girbu L., Jimbei P., Balan G., Cardaniuc I., Benesco I., Marian V., Sumarga N., Bozovic B., Bulatovic N., Lakovic P., Music L., Budde R., Wahadat A., Gamela T., Meijers T., Van Melle J. P., Deursen V. M., Crijns H. J., Bekkers S. C., Cheriex E. C., Gilbers M., Kietselaer B. L., Knackstedt C., Lorusso R., Schalla S., Streukens S. A., Chamuleau S., Cramer M. J., Teske A., Van der Spoel T., Wind A., Lokhorst J., Liesbek O., Van Heusden H., Tanis W., Van der Bilt I., Vriend J., De Lange-van Bruggen H., Karijodikoro E., Riezebos R., van Dongen E., Schoep J., Stolk V., Offstad J. T., Beitnes J. O., Helle-Valle T., Skulstad H., Skardal R., Qamar N., Furnaz S., Ahmed B., Butt M. H., Khanzada M. F., Saghir T., Wahid A., Hryniewiecki T., Szymanski P., Marzec K., Misztal-Ogonowska M., Kosmala W., Przewlocka-Kosmala M., Rojek A., Woznicka K., Zachwyc J., Lisowska A., Kaminska M., Kasprzak J. D., Kowalczyk E., Strzecka D. F., Wejner-Mik P., Trabulo M., Freitas P., Ranchordas S., Rodrigues G., Pinto P., Queiros C., Azevedo J., Marques L., Seabra D., Branco L., Cruz M., Galrinho A., Moreira R., Rio P., Timoteo A. T., Selas M., Carmelo V., Duque Neves B., Pereira H., Guerra A., Marques A., Pintassilgo I., Tomescu M. C., Trofenciuc N. M., Andor M., Bordejevic A., Branea H. S., Caruntu F., Velcean L. A., Mavrea A., Onel M. F., Parvanescu T., Pop D., Pop-Moldovan A. L., Puticiu M. I., Cirin L., Citu I. M., Cotoraci C. A., Darabantiu D., Farcas R., Marincu I., Ionac A., Cozma D., Mornos C., Goanta F., Popescu I., Beyer R., Mada R., Rancea R., Tomoaia R., Rosianu H., Stanescu C., Kobalava Z., Karaulova J., Kotova E., Milto A., Pisaryuk A., Povalyaev N., Sorokina M., Alrahimi J., Elshiekh A., Jamiel A., Ahmed A., Attia N., Putnikovic B., Dimic A., Ivanovic B., Matic S., Trifunovic D., Petrovic J., Kosevic D., Stojanovic I., Petrovic I., Dabic P., Milojevic P., Srdanovic I., Susak S., Velicki L., Vulin A., Kovacevic M., Redzek A., Stefanovic M., Yeo T. C., Kong W. K., Poh K. K., Vilacosta I., Ferrera C., Olmos C., Abd El-Nasser M., Calvo Iglesias F., Blanco-Gonzalez E., Bravo Amaro M., Lopez-Rodriguez E., Lugo Adan J., Germinas A. N., Pazos-Lopez P., Pereira Loureiro M., Perez M. T., Raposeiras-Roubin S., Rasheed Yas S., Suarez-Varela M. M., Vasallo Vidal F., Garcia-Dorado D., Fernandez-Hidalgo N., Gonzalez-Alujas T., Lozano J., Maisterra O., Pizzi N., Rios R., Bayes-Genis A., Pedro Botet L., Vallejo N., Llibre C., Mateu L., Nunez R., Quesada D., Berastegui E., Bosch Portell D., Aboal Vinas J., Albert Bertran X., Brugada Tarradellas R., Loma-Osorio Ricon P., Tiron de Llano C., Arnau M. A., Bel A., Blanes M., Osa A., Anguita M., Carrasco F., Castillo J. C., Zamorano J. L., Moya Mur J. L., Alvaro M., Fernandez-Golfin C., Monteagudo J. M., Navas Elorza E., Farinas Alvarez M. C., Aguero Balbin J., Zarauza J., Gutierrez-Diez J. F., Arminanzas C., Arnaiz de Las Revillas F., Arnaiz Garcia A., Cobo Belaustegui M., Fernandez Sampedro M., Gutierrez Cuadra M., Garcia Cuello L., Gonzalez Rico C., Rodriguez-Alvarez R., Goikoetxea J., Montejo M., Miro J. M., Almela M., Ambrosioni J., Moreno A., Quintana E., Sandoval E., Tellez A., Tolosana J. M., Vidal B., Falces C., Fuster D., Garcia-de-la-Maria C., Hernandez-Meneses M., Llopis J., Marco F., Ruiz-Zamora I., Bardaji Ruiz A., Sanz Girgas E., Garcia-Pardo G., Guillen Marzo M., Rodriguez Oviedo A., Villares Jimenez A., Abid L., Hammami R., Kammoun S., Mourali M. S., Ben Hlima M., Boudiche S., Ouali S., Zakhama L., Antit S., Slama I., Gulel O., Sahin M., Karacaglar E., Kucukoglu S., Cetinarslan O., Yasar U. S., Canpolat U., Mutlu B., Atas H., Dervishova R., Ileri C., Alhashmi J., Tahir J., Zarger P., Baslib F., Woldman S., Menezes L., Primus C., Uppal R., Bvekerwa I., Chandrasekaran B., Kopanska A., Chambers J., Hancock J., Klein J., Rajani R., Ursi M. P., Cannata S., Dworakowski R., Fife A., Breeze J., Browne-Morgan M., Gunning M., Streather S., Asch F. M., Zemedkun M., Alyavi B., and Uzokov J.
- Abstract
Aims: The EURO-ENDO registry aimed to study the management and outcomes of patients with infective endocarditis (IE). Methods and results: Prospective cohort of 3116 adult patients (2470 from Europe, 646 from non-ESC countries), admitted to 156 hospitals in 40 countries between January 2016 and March 2018 with a diagnosis of IE based on ESC 2015 diagnostic criteria. Clinical, biological, microbiological, and imaging [echocardiography, computed tomography (CT) scan, 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT)] data were collected. Infective endocarditis was native (NVE) in 1764 (56.6%) patients, prosthetic (PVIE) in 939 (30.1%), and device-related (CDRIE) in 308 (9.9%). Infective endocarditis was community-acquired in 2046 (65.66%) patients. Microorganisms involved were staphylococci in 1085 (44.1%) patients, oral streptococci in 304 (12.3%), enterococci in 390 (15.8%), and Streptococcus gallolyticus in 162 (6.6%). 18F-fluorodeoxyglucose positron emission tomography/computed tomography was performed in 518 (16.6%) patients and presented with cardiac uptake (major criterion) in 222 (42.9%) patients, with a better sensitivity in PVIE (66.8%) than in NVE (28.0%) and CDRIE (16.3%). Embolic events occurred in 20.6% of patients, and were significantly associated with tricuspid or pulmonary IE, presence of a vegetation and Staphylococcus aureus IE. According to ESC guidelines, cardiac surgery was indicated in 2160 (69.3%) patients, but finally performed in only 1596 (73.9%) of them. In-hospital death occurred in 532 (17.1%) patients and was more frequent in PVIE. Independent predictors of mortality were Charlson index, creatinine > 2 mg/dL, congestive heart failure, vegetation length > 10 mm, cerebral complications, abscess, and failure to undertake surgery when indicated. Conclusion: Infective endocarditis is still a life-threatening disease with frequent lethal outcome despite profound changes in its clinical, microbiolog
- Published
- 2019
18. 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes
- Author
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Knuuti, Juhani, Wijns, William, Saraste, Antti, Capodanno, Davide, Barbato, Emanuele, Funck-Brentano, Christian, Prescott, Eva, Storey, Robert F, Deaton, Christi, Cuisset, Thomas, Agewall, Stefan, Dickstein, Kenneth, Edvardsen, Thor, Escaned, Javier, Gersh, Bernard J, Svitil, Pavel, Gilard, Martine, Hasdai, David, Hatala, Robert, Mahfoud, Felix, Masip, Josep, Muneretto, Claudio, Valgimigli, Marco, Achenbach, Stephan, Bax, Jeroen J, Neumann FJ, Sechtem U, Banning AP, Bonaros N, Bueno H, Bugiardini R, Chieffo A, Crea F, Czerny M, Delgado V, Dendale P, Flachskampf FA, Gohlke H, Grove EL, James S, Katritsis D, Landmesser U, Lettino M, Matter CM, Nathoe H, Niessner A, Patrono C, Petronio AS, Pettersen SE, Piccolo R, Piepoli MF, Popescu BA, Räber L, Richter DJ, Roffi M, Roithinger FX, Shlyakhto E, Sibbing D, Silber S, Simpson IA, Sousa-Uva M, Vardas P, Witkowski A, Zamorano JL, Achenbach S, Agewall S, Barbato E, Bax JJ, Capodanno D, Cuisset T, Deaton C, Dickstein K, Edvardsen T, Escaned J, Funck-Brentano C, Gersh BJ, Gilard M, Hasdai D, Hatala R, Mahfoud F, Masip J, Muneretto C, Prescott E, Saraste A, Storey RF, Svitil P, Valgimigli M, Windecker S, Aboyans V, Baigent C, Collet JP, Dean V, Fitzsimons D, Gale CP, Grobbee D, Halvorsen S, Hindricks G, Iung B, Jüni P, Katus HA, Leclercq C, Lewis BS, Merkely B, Mueller C, Petersen S, Touyz RM, Benkhedda S, Metzler B, Sujayeva V, Cosyns B, Kusljugic Z, Velchev V, Panayi G, Kala P, Haahr-Pedersen SA, Kabil H, Ainla T, Kaukonen T, Cayla G, Pagava Z, Woehrle J, Kanakakis J, Tóth K, Gudnason T, Peace A, Aronson D, Riccio C, Elezi S, Mirrakhimov E, Hansone S, Sarkis A, Babarskiene R, Beissel J, Maempel AJC, Revenco V, de Grooth GJ, Pejkov H, Juliebø V, Lipiec P, Santos J, Chioncel O, Duplyakov D, Bertelli L, Dikic AD, Studenčan M, Bunc M, Alfonso F, Bäck M, Zellweger M, Addad F, Yildirir A, Sirenko Y, Clapp B, Sorbonne Université (SU), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de pharmacologie médicale [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Département de Cardiologie [Hôpital de la Timone - APHM], Hôpital de la Timone [CHU - APHM] (TIMONE)-Assistance Publique - Hôpitaux de Marseille (APHM), Knuuti, Juhani, Wijns, William, Saraste, Antti, Capodanno, Davide, Barbato, Emanuele, Funck-Brentano, Christian, Prescott, Eva, Storey, Robert F, Deaton, Christi, Cuisset, Thoma, Agewall, Stefan, Dickstein, Kenneth, Edvardsen, Thor, Escaned, Javier, Gersh, Bernard J, Svitil, Pavel, Gilard, Martine, Hasdai, David, Hatala, Robert, Mahfoud, Felix, Masip, Josep, Muneretto, Claudio, Valgimigli, Marco, Achenbach, Stephan, Bax, Jeroen J, Neumann FJ, Sechtem U, Banning AP, Bonaros N, Bueno H, Bugiardini R, Chieffo A, Crea F, Czerny M, Delgado V, Dendale P, Flachskampf FA, Gohlke H, Grove EL, James S, Katritsis D, Landmesser U, Lettino M, Matter CM, Nathoe H, Niessner A, Patrono C, Petronio AS, Pettersen SE, Piccolo R, Piepoli MF, Popescu BA, Räber L, Richter DJ, Roffi M, Roithinger FX, Shlyakhto E, Sibbing D, Silber S, Simpson IA, Sousa-Uva M, Vardas P, Witkowski A, Zamorano JL, Achenbach S, Agewall S, Barbato E, Bax JJ, Capodanno D, Cuisset T, Deaton C, Dickstein K, Edvardsen T, Escaned J, Funck-Brentano C, Gersh BJ, Gilard M, Hasdai D, Hatala R, Mahfoud F, Masip J, Muneretto C, Prescott E, Saraste A, Storey RF, Svitil P, Valgimigli M, Windecker S, Aboyans V, Baigent C, Collet JP, Dean V, Delgado V, Fitzsimons D, Gale CP, Grobbee D, Halvorsen S, Hindricks G, Iung B, Jüni P, Katus HA, Landmesser U, Leclercq C, Lettino M, Lewis BS, Merkely B, Mueller C, Petersen S, Petronio AS, Richter DJ, Roffi M, Shlyakhto E, Simpson IA, Sousa-Uva M, Touyz RM, Benkhedda S, Metzler B, Sujayeva V, Cosyns B, Kusljugic Z, Velchev V, Panayi G, Kala P, Haahr-Pedersen SA, Kabil H, Ainla T, Kaukonen T, Cayla G, Pagava Z, Woehrle J, Kanakakis J, Tóth K, Gudnason T, Peace A, Aronson D, Riccio C, Elezi S, Mirrakhimov E, Hansone S, Sarkis A, Babarskiene R, Beissel J, Maempel AJC, Revenco V, de Grooth GJ, Pejkov H, Juliebø V, Lipiec P, Santos J, Chioncel O, Duplyakov D, Bertelli L, Dikic AD, Studenčan M, Bunc M, Alfonso F, Bäck M, Zellweger M, Addad F, Yildirir A, Sirenko Y, Clapp B, Clinical sciences, Cardio-vascular diseases, Cardiology, Knuuti, Juhani [0000-0003-3156-9593], Apollo - University of Cambridge Repository, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), University of Zurich, Knuuti, J., Wijns, W., Achenbach, S., Agewall, S., Barbato, E., Bax, J. J., Capodanno, D., Cuisset, T., Deaton, C., Dickstein, K., Edvardsen, T., Escaned, J., Funck-Brentano, C., Gersh, B. J., Gilard, M., Hasdai, D., Hatala, R., Mahfoud, F., Masip, J., Muneretto, C., Prescott, E., Saraste, A., Storey, R. F., Svitil, P., Valgimigli, M., Windecker, S., Aboyans, V., Baigent, C., Collet, J. -P., Dean, V., Delgado, V., Fitzsimons, D., Gale, C. P., Grobbee, D. E., Halvorsen, S., Hindricks, G., Iung, B., Juni, P., Katus, H. A., Landmesser, U., Leclercq, C., Lettino, M., Lewis, B. S., Merkely, B., Mueller, C., Petersen, S., Petronio, A. S., Richter, D. J., Roffi, M., Shlyakhto, E., Simpson, I. A., Sousa-Uva, M., Touyz, R. M., Benkhedda, S., Metzler, B., Sujayeva, V., Cosyns, B., Kusljugic, Z., Velchev, V., Panayi, G., Kala, P., Haahr-Pedersen, S. A., Kabil, H., Ainla, T., Kaukonen, T., Cayla, G., Pagava, Z., Woehrle, J., Kanakakis, J., Toth, K., Gudnason, T., Peace, A., Aronson, D., Riccio, C., Elezi, S., Mirrakhimov, E., Hansone, S., Sarkis, A., Babarskiene, R., Beissel, J., Cassar Maempel, A. J., Revenco, V., de Grooth, G. J., Pejkov, H., Juliebo, V., Lipiec, P., Santos, J., Chioncel, O., Duplyakov, D., Bertelli, L., Dikic, A. D., Studencan, M., Bunc, M., Alfonso, F., Back, M., Zellweger, M., Addad, F., Yildirir, A., Sirenko, Y., and Clapp, B.
- Subjects
anti-ischaemic drug ,chronic coronary syndromes ,medicine.medical_treatment ,[SDV]Life Sciences [q-bio] ,lipid-lowering drugs ,Diagnostic Techniques, Cardiovascular ,antithrombotic therapy ,Disease ,030204 cardiovascular system & hematology ,Guideline ,Coronary artery disease ,0302 clinical medicine ,Disease management (health) ,Societies, Medical ,ComputingMilieux_MISCELLANEOUS ,chronic coronary syndrome ,angina pectori ,Disease Management ,food and beverages ,imaging ,risk assessment ,Syndrome ,3. Good health ,Natural history ,Europe ,Cardiology ,Cardiology and Cardiovascular Medicine ,coronary artery disease ,medicine.medical_specialty ,lifestyle modifications ,anti-ischaemic drugs ,Ischemia ,610 Medicine & health ,vasospastic angina ,Guidelines ,Revascularization ,diagnostic testing ,11171 Cardiocentro Ticino ,2705 Cardiology and Cardiovascular Medicine ,03 medical and health sciences ,angina pectoris ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Internal medicine ,medicine ,Journal Article ,Humans ,business.industry ,screening ,fungi ,030229 sport sciences ,medicine.disease ,lipid-lowering drug ,Angina pectoris ,Anti-ischaemic drugs ,Antithrombotic therapy ,Chronic coronary syndromes ,Diagnostic testing ,Imaging ,Lifestyle modifications ,Lipid-lowering drugs ,Microvascular angina ,Myocardial ischaemia ,Myocardial revascularization ,Risk assessment ,Screening ,Vasospastic angina ,myocardial ischaemia ,myocardial revascularization ,Heart failure ,microvascular angina ,Chronic Disease ,Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE ,lifestyle modification ,Coronary Artery Disease/diagnosis ,business ,Fibrinolytic agent - Abstract
Coronary artery disease (CAD) is a pathological process characterized by atherosclerotic plaque accumulation in the epicardial arteries, whether obstructive or non-obstructive. This process can be modified by lifestyle adjustments, pharmacological therapies, and invasive interventions designed to achieve disease stabilization or regression. The disease can have long, stable periods but can also become unstable at any time, typically due to an acute atherothrombotic event caused by plaque rupture or erosion. However, the disease is chronic, most often progressive, and hence serious, even in clinically apparently silent periods. The dynamic nature of the CAD process results in various clinical presentations, which can be conveniently categorized as either acute coronary syndromes (ACS) or chronic coronary syndromes (CCS). The Guidelines presented here refer to the management of patients with CCS. The natural history of CCS is illustrated in Figure 1.
- Published
- 2019
19. Unravelling the interplay between hyperkalaemia, renin-angiotensin-aldosterone inhibitor use and clinical outcomes. Data from 9222 chronic heart failure patients of the ESC-HFA-EORP Heart Failure Long-Term Registry
- Author
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Rossignol, P., Lainscak, M., Crespo-Leiro, M. G., Laroche, C., Piepoli, M. F., Filippatos, G., Rosano, G. M. C., Savarese, G., Anker, S. D., Seferovic, P. M., Ruschitzka, F., Coats, A. J. S., Mebazaa, A., Mcdonagh, T., Sahuquillo, A., Penco, M., Maggioni, A. P., Lund, L. H., Christopher Peter Gale, G. B., Branko Beleslin, R. S., Andrzej Budaj, P. L., Ovidiu Chioncel, R. O., Nikolaos Dagres, D. E., Nicolas Danchin, F. R., David Erlinge, S. E., Jonathan Emberson, G. B., Michael Glikson, I. L., Alastair Gray, G. B., Meral Kayikcioglu, T. R., Aldo Maggioni, I. T., Klaudia Vivien Nagy, H. U., Aleksandr Nedoshivin, R. U., Anna-Sonia Petronio, I. T., Jolien Roos-Hesselink, N. L., Lars Wallentin, S. E., Uwe Zeymer, D. E., Crespo-Leiro, M., Anker, S., Coats, A., Ferrari, R., Goda, A., Diez, M., Fernandez, A., Fruhwald, F., Fazlibegovic, E., Gatzov, P., Kurlianskaya, A., Hullin, R., Christodoulides, T., Hradec, J., Nielsen, O. W., Nedjar, R., Uuetoa, T., Hassanein, M., Jimenez, J. F. D., Harjola, V. P., Logeart, D., Chumburidze, V., Tousoulis, D., Milicic, D., Merkely, B., O'Donoghue, E., Amir, O., Shotan, A., Shafie, D., Metra, M., Matsumori, A., Mirrakhimov, E., Kavoliuniene, A., Erglis, A., Vataman, E., Otljanska, M., Kostovska, E. S., Demarco, D. C., Drozdz, J., Fonseca, C., Chioncel, O., Dekleva, M., Shkolnik, E., Dahlstrom, U., Goncalvesova, E., Temizhan, A., Estrago, V., Bajraktari, G., Auer, J., Ablasser, K., Dolze, T., Brandner, K., Gstrein, S., Poelzl, G., Moertl, D., Reiter, S., Podczeck-Schweighofer, A., Muslibegovic, A., Vasilj, M., Cesko, M., Zelenika, D., Palic, B., Pravdic, D., Cuk, D., Vitlianova, K., Katova, T., Velikov, T., Kurteva, T., Kamenova, D., Antova, M., Sirakova, V., Krejci, J., Mikolaskova, M., Spinar, J., Krupicka, J., Malek, F., Hegarova, M., Lazarova, M., Monhart, Z., Sobhy, M., El Messiry, F., El Shazly, A. H., Elrakshy, Y., Youssef, A., Moneim, A. A., Noamany, M., Reda, A., Dayem, T. K. A., Farag, N., Halawa, S. I., Hamid, M. A., Said, K., Saleh, A., Ebeid, H., Hanna, R., Aziz, R., Louis, O., Enen, M. A., Ibrahim, B. S., Nasr, G., Elbahry, A., Sobhy, H., Ashmawy, M., Gouda, M., Aboleineen, W., Bernard, Y., Luporsi, P., Meneveau, N., Pillot, M., Morel, M., Seronde, M. -F., Schiele, F., Briand, F., Delahaye, F., Damy, T., Eicher, J. -C., de Groote, P., Fertin, M., Lamblin, N., Isnard, R., Lefol, C., Thevenin, S., Hagege, A., Jondeau, G., Le Marcis, V., J. -F., Ly, Coisne, D., Lequeux, B., Le Moal, V., Mascle, S., Lotton, P., Behar, N., Donal, E., Thebault, C., Ridard, C., Reynaud, A., Basquin, A., Bauer, F., Codjia, R., Galinier, M., Tourikis, P., Stavroula, M., Stefanadis, C., Chrysohoou, C., Kotrogiannis, I., Matzaraki, V., Dimitroula, T., Karavidas, A., Tsitsinakis, G., Kapelios, C., Nanas, J., Kampouri, H., Nana, E., Kaldara, E., Eugenidou, A., Vardas, P., Saloustros, I., Patrianakos, A., Tsaknakis, T., Evangelou, S., Nikoloulis, N., Tziourganou, H., Tsaroucha, A., Papadopoulou, A., Douras, A., Polgar, L., Kosztin, A., Nyolczas, N., Nagy, A. C., Halmosi, R., Elber, J., Alony, I., Fuhrmann, A. V., Romano, S., Marcon, S., Di Mauro, M., Lemme, E., Carubelli, V., Rovetta, R., Bulgari, M., Quinzani, F., Lombardi, C., Bosi, S., Schiavina, G., Squeri, A., Barbieri, A., Di Tano, G., Pirelli, S., Fucili, A., Passero, T., Musio, S., Di Biase, M., Correale, M., Salvemini, G., Brognoli, S., Zanelli, E., Giordano, A., Agostoni, P., Italiano, G., Salvioni, E., Copelli, S., Modena, M. G., Reggianini, L., Valenti, C., Olaru, A., Bandino, S., Deidda, M., Mercuro, G., Dessalvi, C. C., Marino, P. N., Di Ruocco, M. V., Sartori, C., Piccinino, C., Parrinello, G., Licata, G., Torres, D., Giambanco, S., Busalacchi, S., Arrotti, S., Novo, S., Inciardi, R. M., Pieri, P., Chirco, P. R., Galifi, M. A., Teresi, G., Buccheri, D., Minacapelli, A., Veniani, M., Frisinghelli, A., Priori, S. G., Cattaneo, S., Opasich, C., Gualco, A., Pagliaro, M., Mancone, M., Fedele, F., Cinque, A., Vellini, M., Scarfo, I., Romeo, F., Ferraiuolo, F., Sergi, D., Anselmi, M., Melandri, F., Leci, E., Iori, E., Bovolo, V., Pidello, S., Frea, S., Bergerone, S., Botta, M., Canavosio, F. G., Gaita, F., Merlo, M., Cinquetti, M., Sinagra, G., Ramani, F., Fabris, E., Stolfo, D., Artico, J., Miani, D., Fresco, C., Daneluzzi, C., Proclemer, A., Cicoira, M., Zanolla, L., Marchese, G., Torelli, F., Vassanelli, C., Voronina, N., Tamakauskas, V., Smalinskas, V., Karaliute, R., Petraskiene, I., Kazakauskaite, E., Rumbinaite, E., Vysniauskas, V., Brazyte-Ramanauskiene, R., Petraskiene, D., Stankala, S., Switala, P., Juszczyk, Z., Sinkiewicz, W., Gilewski, W., Pietrzak, J., Orzel, T., Kasztelowicz, P., Kardaszewicz, P., Lazorko-Piega, M., Gabryel, J., Mosakowska, K., Bellwon, J., Rynkiewicz, A., Raczak, G., Lewicka, E., Dabrowska-Kugacka, A., Bartkowiak, R., Sosnowska-Pasiarska, B., Wozakowska-Kaplon, B., Krzeminski, A., Zabojszcz, M., Mirek-Bryniarska, E., Grzegorzko, A., Bury, K., Nessler, J., Zalewski, J., Furman, A., Broncel, M., Poliwczak, A., Bala, A., Zycinski, P., Rudzinska, M., Jankowski, L., Kasprzak, J. D., Michalak, L., Soska, K. W., Huziuk, I., Retwinski, A., Flis, P., Weglarz, J., Bodys, A., Grajek, S., Kaluzna-Oleksy, M., Straburzynska-Migaj, E., Dankowski, R., Szymanowska, K., Grabia, J., Szyszka, A., Nowicka, A., Samcik, M., Wolniewicz, L., Baczynska, K., Komorowska, K., Poprawa, I., Komorowska, E., Sajnaga, D., Zolbach, A., Dudzik-Plocica, A., Abdulkarim, A. -F., Lauko-Rachocka, A., Kaminski, L., Kostka, A., Cichy, A., Ruszkowski, P., Splawski, M., Fitas, G., Szymczyk, A., Serwicka, A., Fiega, A., Zysko, D., Krysiak, W., Szabowski, S., Skorek, E., Pruszczyk, P., Bienias, P., Ciurzynski, M., Welnicki, M., Mamcarz, A., Folga, A., Zielinski, T., Rywik, T., Leszek, P., Sobieszczanska-Malek, M., Piotrowska, M., Kozar-Kaminska, K., Komuda, K., Wisniewska, J., Tarnowska, A., Balsam, P., Marchel, M., Opolski, G., Kaplon-Cieslicka, A., Gil, R. J., Mozenska, O., Byczkowska, K., Gil, K., Pawlak, A., Michalek, A., Krzesinski, P., Piotrowicz, K., Uzieblo-Zyczkowska, B., Stanczyk, A., Skrobowski, A., Ponikowski, P., Jankowska, E., Rozentryt, P., Polonski, L., Gadula-Gacek, E., Nowalany-Kozielska, E., Kuczaj, A., Kalarus, Z., Szulik, M., Przybylska, K., Klys, J., Prokop-Lewicka, G., Kleinrok, A., Aguiar, C. T., Ventosa, A., Pereira, S., Faria, R., Chin, J., De Jesus, I., Santos, R., Silva, P., Moreno, N., Queiros, C., Lourenco, C., Pereira, A., Castro, A., Andrade, A., Guimaraes, T. O., Martins, S., Placido, R., Lima, G., Brito, D., Francisco, A. R., Cardiga, R., Proenca, M., Araujo, I., Marques, F., Moura, B., Leite, S., Campelo, M., Silva-Cardoso, J., Rodrigues, J., Rangel, I., Martins, E., Correia, A. S., Peres, M., Marta, L., da Silva, G. F., Severino, D., Durao, D., Leao, S., Magalhaes, P., Moreira, I., Cordeiro, A. F., Ferreira, C., Araujo, C., Ferreira, A., Baptista, A., Radoi, M., Bicescu, G., Vinereanu, D., Sinescu, C. -J., Macarie, C., Popescu, R., Daha, I., Dan, G. -A., Stanescu, C., Dan, A., Craiu, E., Nechita, E., Aursulesei, V., Christodorescu, R., Otasevic, P., Simeunovic, D., Ristic, A. D., Celic, V., Pavlovic-Kleut, M., Lazic, J. S., Stojcevski, B., Pencic, B., Stevanovic, A., Andric, A., Simic, D., Asanin, M., Iric-Cupic, V., Jovic, M., Davidovic, G., Milanov, S., Mitic, V., Atanaskovic, V., Antic, S., Pavlovic, M., Stanojevic, D., Stoickov, V., Ilic, S., Ilic, M. D., Petrovic, D., Stojsic, S., Kecojevic, S., Dodic, S., Adic, N. C., Cankovic, M., Stojiljkovic, J., Mihajlovic, B., Radin, A., Radovanovic, S., Krotin, M., Klabnik, A., Pernicky, M., Murin, J., Kovar, F., Kmec, J., Semjanova, H., Strasek, M., Iskra, M. S., Ravnikar, T., Suligoj, N. C., Komel, J., Fras, Z., Jug, B., Glavic, T., Losic, R., Bombek, M., Krajnc, I., Krunic, B., Horvat, S., Kovac, D., Rajtman, D., Cencic, V., Letonja, M., Winkler, R., Valentincic, M., Melihen-Bartolic, C., Bartolic, A., Vrckovnik, M. P., Kladnik, M., Pusnik, C. S., Marolt, A., Klen, J., Drnovsek, B., Leskovar, B., Anguita, M. J. F., Page, J. C. G., Martinez, F. M. S., Andres, J., Bayes-Genis, A., Mirabet, S., Mendez, A., Garcia-Cosio, L., Roig, E., Leon, V., Gonzalez-Costello, J., Muntane, G., Garay, A., Alcade-Martinez, V., Fernandez, S. L., Rivera-Lopez, R., Puga-Martinez, M., Fernandez-Alvarez, M., Serrano-Martinez, J. L., Grille-Cancela, Z., Marzoa-Rivas, R., Blanco-Canosa, P., Paniagua-Martin, M. J., Barge-Caballero, E., Cerdena, I. L., Baldomero, I. F. H., Padron, A. L., Rosillo, S. O., Gonzalez-Gallarza, R. D., Montanes, O. S., Manjavacas, A. M. I., Conde, A. C., Araujo, A., Soria, T., Garcia-Pavia, P., Gomez-Bueno, M., Cobo-Marcos, M., Alonso-Pulpon, L., Cubero, J. S., Sayago, I., Gonzalez-Segovia, A., Briceno, A., Subias, P. E., Hernandez, M. V., Cano, M. J. R., Sanchez, M. A. G., Garrido-Lestache, E. B., Pinilla, J. M. G., de la Villa, B. G., Marques, R. B., Calvo, F. T., Perez-Martinez, M. T., Gracia-Rodenas, M. R., Garrido-Bravo, I. P., Pastor-Perez, F., Pascual-Figal, D. A., Molina, B. D., Orus, J., Gonzalo, F. E., Bertomeu, V., Valero, R., Martinez-Abellan, R., Quiles, J., Rodrigez-Ortega, J. A., Mateo, I., Elamrani, A., Fernandez-Vivancos, C., Valero, D. B., Almenar-Bonet, L., Sanchez-Lazaro, I. J., Marques-Sule, E., Facila-Rubio, L., Perez-Silvestre, J., Garcia-Gonzalez, P., Ridocci-Soriano, F., Garcia-Escriva, D., Pellicer-Cabo, A., de la Fuente Galan, L., Diaz, J. L., Platero, A. R., Arias, J. C., Blasco-Peiro, T., Julve, M. S., Sanchez-Insa, E., Aured-Guallar, C., Portoles-Ocampo, A., Melin, M., Hagglund, E., Stenberg, A., Lindahl, I. -M., Asserlund, B., Olsson, L., Afzelius, M., Karlstrom, P., Tengvall, L., Olsson, B., Kalayci, S., Cavusoglu, Y., Gencer, E., Yilmaz, M. B., Gunes, H., Modena, Mg, University of Zurich, Rossignol, Patrick, Rossignol, P., Lainscak, M., Crespo-Leiro, M. G., Laroche, C., Piepoli, M. F., Filippatos, G., Rosano, G. M. C., Savarese, G., Anker, S. D., Seferovic, P. M., Ruschitzka, F., Coats, A. J. S., Mebazaa, A., Mcdonagh, T., Sahuquillo, A., Penco, M., Maggioni, A. P., Lund, L. H., Christopher Peter Gale, G. B., Branko Beleslin, R. S., Andrzej Budaj, P. L., Ovidiu Chioncel, R. O., Nikolaos Dagres, D. E., Nicolas Danchin, F. R., David Erlinge, S. E., Jonathan Emberson, G. B., Michael Glikson, I. L., Alastair Gray, G. B., Meral Kayikcioglu, T. R., Aldo Maggioni, I. T., Klaudia Vivien Nagy, H. U., Aleksandr Nedoshivin, R. U., Anna-Sonia Petronio, I. T., Jolien Roos-Hesselink, N. L., Lars Wallentin, S. E., Uwe Zeymer, D. E., Crespo-Leiro, M., Anker, S., Coats, A., Ferrari, R., Goda, A., Diez, M., Fernandez, A., Fruhwald, F., Fazlibegovic, E., Gatzov, P., Kurlianskaya, A., Hullin, R., Christodoulides, T., Hradec, J., Nielsen, O. W., Nedjar, R., Uuetoa, T., Hassanein, M., Jimenez, J. F. D., Harjola, V. P., Logeart, D., Chumburidze, V., Tousoulis, D., Milicic, D., Merkely, B., O'Donoghue, E., Amir, O., Shotan, A., Shafie, D., Metra, M., Matsumori, A., Mirrakhimov, E., Kavoliuniene, A., Erglis, A., Vataman, E., Otljanska, M., Kostovska, E. S., Demarco, D. C., Drozdz, J., Fonseca, C., Chioncel, O., Dekleva, M., Shkolnik, E., Dahlstrom, U., Goncalvesova, E., Temizhan, A., Estrago, V., Bajraktari, G., Auer, J., Ablasser, K., Dolze, T., Brandner, K., Gstrein, S., Poelzl, G., Moertl, D., Reiter, S., Podczeck-Schweighofer, A., Muslibegovic, A., Vasilj, M., Cesko, M., Zelenika, D., Palic, B., Pravdic, D., Cuk, D., Vitlianova, K., Katova, T., Velikov, T., Kurteva, T., Kamenova, D., Antova, M., Sirakova, V., Krejci, J., Mikolaskova, M., Spinar, J., Krupicka, J., Malek, F., Hegarova, M., Lazarova, M., Monhart, Z., Sobhy, M., El Messiry, F., El Shazly, A. H., Elrakshy, Y., Youssef, A., Moneim, A. A., Noamany, M., Reda, A., Dayem, T. K. A., Farag, N., Halawa, S. I., Hamid, M. A., Said, K., Saleh, A., Ebeid, H., Hanna, R., Aziz, R., Louis, O., Enen, M. A., Ibrahim, B. S., Nasr, G., Elbahry, A., Sobhy, H., Ashmawy, M., Gouda, M., Aboleineen, W., Bernard, Y., Luporsi, P., Meneveau, N., Pillot, M., Morel, M., Seronde, M. -F., Schiele, F., Briand, F., Delahaye, F., Damy, T., Eicher, J. -C., de Groote, P., Fertin, M., Lamblin, N., Isnard, R., Lefol, C., Thevenin, S., Hagege, A., Jondeau, G., Le Marcis, V., Ly, J. -F., Coisne, D., Lequeux, B., Le Moal, V., Mascle, S., Lotton, P., Behar, N., Donal, E., Thebault, C., Ridard, C., Reynaud, A., Basquin, A., Bauer, F., Codjia, R., Galinier, M., Tourikis, P., Stavroula, M., Stefanadis, C., Chrysohoou, C., Kotrogiannis, I., Matzaraki, V., Dimitroula, T., Karavidas, A., Tsitsinakis, G., Kapelios, C., Nanas, J., Kampouri, H., Nana, E., Kaldara, E., Eugenidou, A., Vardas, P., Saloustros, I., Patrianakos, A., Tsaknakis, T., Evangelou, S., Nikoloulis, N., Tziourganou, H., Tsaroucha, A., Papadopoulou, A., Douras, A., Polgar, L., Kosztin, A., Nyolczas, N., Nagy, A. C., Halmosi, R., Elber, J., Alony, I., Fuhrmann, A. V., Romano, S., Marcon, S., Di Mauro, M., Lemme, E., Carubelli, V., Rovetta, R., Bulgari, M., Quinzani, F., Lombardi, C., Bosi, S., Schiavina, G., Squeri, A., Barbieri, A., Di Tano, G., Pirelli, S., Fucili, A., Passero, T., Musio, S., Di Biase, M., Correale, M., Salvemini, G., Brognoli, S., Zanelli, E., Giordano, A., Agostoni, P., Italiano, G., Salvioni, E., Copelli, S., Modena, M. G., Reggianini, L., Valenti, C., Olaru, A., Bandino, S., Deidda, M., Mercuro, G., Dessalvi, C. C., Marino, P. N., Di Ruocco, M. V., Sartori, C., Piccinino, C., Parrinello, G., Licata, G., Torres, D., Giambanco, S., Busalacchi, S., Arrotti, S., Novo, S., Inciardi, R. M., Pieri, P., Chirco, P. R., Galifi, M. A., Teresi, G., Buccheri, D., Minacapelli, A., Veniani, M., Frisinghelli, A., Priori, S. 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G., Gaita, F., Merlo, M., Cinquetti, M., Sinagra, G., Ramani, F., Fabris, E., Stolfo, D., Artico, J., Miani, D., Fresco, C., Daneluzzi, C., Proclemer, A., Cicoira, M., Zanolla, L., Marchese, G., Torelli, F., Vassanelli, C., Voronina, N., Tamakauskas, V., Smalinskas, V., Karaliute, R., Petraskiene, I., Kazakauskaite, E., Rumbinaite, E., Vysniauskas, V., Brazyte-Ramanauskiene, R., Petraskiene, D., Stankala, S., Switala, P., Juszczyk, Z., Sinkiewicz, W., Gilewski, W., Pietrzak, J., Orzel, T., Kasztelowicz, P., Kardaszewicz, P., Lazorko-Piega, M., Gabryel, J., Mosakowska, K., Bellwon, J., Rynkiewicz, A., Raczak, G., Lewicka, E., Dabrowska-Kugacka, A., Bartkowiak, R., Sosnowska-Pasiarska, B., Wozakowska-Kaplon, B., Krzeminski, A., Zabojszcz, M., Mirek-Bryniarska, E., Grzegorzko, A., Bury, K., Nessler, J., Zalewski, J., Furman, A., Broncel, M., Poliwczak, A., Bala, A., Zycinski, P., Rudzinska, M., Jankowski, L., Kasprzak, J. D., Michalak, L., Soska, K. W., Huziuk, I., Retwinski, A., Flis, P., Weglarz, J., Bodys, A., Grajek, S., Kaluzna-Oleksy, M., Straburzynska-Migaj, E., Dankowski, R., Szymanowska, K., Grabia, J., Szyszka, A., Nowicka, A., Samcik, M., Wolniewicz, L., Baczynska, K., Komorowska, K., Poprawa, I., Komorowska, E., Sajnaga, D., Zolbach, A., Dudzik-Plocica, A., Abdulkarim, A. -F., Lauko-Rachocka, A., Kaminski, L., Kostka, A., Cichy, A., Ruszkowski, P., Splawski, M., Fitas, G., Szymczyk, A., Serwicka, A., Fiega, A., Zysko, D., Krysiak, W., Szabowski, S., Skorek, E., Pruszczyk, P., Bienias, P., Ciurzynski, M., Welnicki, M., Mamcarz, A., Folga, A., Zielinski, T., Rywik, T., Leszek, P., Sobieszczanska-Malek, M., Piotrowska, M., Kozar-Kaminska, K., Komuda, K., Wisniewska, J., Tarnowska, A., Balsam, P., Marchel, M., Opolski, G., Kaplon-Cieslicka, A., Gil, R. J., Mozenska, O., Byczkowska, K., Gil, K., Pawlak, A., Michalek, A., Krzesinski, P., Piotrowicz, K., Uzieblo-Zyczkowska, B., Stanczyk, A., Skrobowski, A., Ponikowski, P., Jankowska, E., Rozentryt, P., Polonski, L., Gadula-Gacek, E., Nowalany-Kozielska, E., Kuczaj, A., Kalarus, Z., Szulik, M., Przybylska, K., Klys, J., Prokop-Lewicka, G., Kleinrok, A., Aguiar, C. T., Ventosa, A., Pereira, S., Faria, R., Chin, J., De Jesus, I., Santos, R., Silva, P., Moreno, N., Queiros, C., Lourenco, C., Pereira, A., Castro, A., Andrade, A., Guimaraes, T. O., Martins, S., Placido, R., Lima, G., Brito, D., Francisco, A. R., Cardiga, R., Proenca, M., Araujo, I., Marques, F., Moura, B., Leite, S., Campelo, M., Silva-Cardoso, J., Rodrigues, J., Rangel, I., Martins, E., Correia, A. S., Peres, M., Marta, L., da Silva, G. F., Severino, D., Durao, D., Leao, S., Magalhaes, P., Moreira, I., Cordeiro, A. F., Ferreira, C., Araujo, C., Ferreira, A., Baptista, A., Radoi, M., Bicescu, G., Vinereanu, D., Sinescu, C. -J., Macarie, C., Popescu, R., Daha, I., Dan, G. -A., Stanescu, C., Dan, A., Craiu, E., Nechita, E., Aursulesei, V., Christodorescu, R., Otasevic, P., Simeunovic, D., Ristic, A. D., Celic, V., Pavlovic-Kleut, M., Lazic, J. S., Stojcevski, B., Pencic, B., Stevanovic, A., Andric, A., Simic, D., Asanin, M., Iric-Cupic, V., Jovic, M., Davidovic, G., Milanov, S., Mitic, V., Atanaskovic, V., Antic, S., Pavlovic, M., Stanojevic, D., Stoickov, V., Ilic, S., Ilic, M. D., Petrovic, D., Stojsic, S., Kecojevic, S., Dodic, S., Adic, N. C., Cankovic, M., Stojiljkovic, J., Mihajlovic, B., Radin, A., Radovanovic, S., Krotin, M., Klabnik, A., Pernicky, M., Murin, J., Kovar, F., Kmec, J., Semjanova, H., Strasek, M., Iskra, M. S., Ravnikar, T., Suligoj, N. C., Komel, J., Fras, Z., Jug, B., Glavic, T., Losic, R., Bombek, M., Krajnc, I., Krunic, B., Horvat, S., Kovac, D., Rajtman, D., Cencic, V., Letonja, M., Winkler, R., Valentincic, M., Melihen-Bartolic, C., Bartolic, A., Vrckovnik, M. P., Kladnik, M., Pusnik, C. S., Marolt, A., Klen, J., Drnovsek, B., Leskovar, B., Anguita, M. J. F., Page, J. C. G., Martinez, F. M. S., Andres, J., Bayes-Genis, A., Mirabet, S., Mendez, A., Garcia-Cosio, L., Roig, E., Leon, V., Gonzalez-Costello, J., Muntane, G., Garay, A., Alcade-Martinez, V., Fernandez, S. L., Rivera-Lopez, R., Puga-Martinez, M., Fernandez-Alvarez, M., Serrano-Martinez, J. L., Grille-Cancela, Z., Marzoa-Rivas, R., Blanco-Canosa, P., Paniagua-Martin, M. J., Barge-Caballero, E., Cerdena, I. L., Baldomero, I. F. H., Padron, A. L., Rosillo, S. O., Gonzalez-Gallarza, R. D., Montanes, O. S., Manjavacas, A. M. I., Conde, A. C., Araujo, A., Soria, T., Garcia-Pavia, P., Gomez-Bueno, M., Cobo-Marcos, M., Alonso-Pulpon, L., Cubero, J. S., Sayago, I., Gonzalez-Segovia, A., Briceno, A., Subias, P. E., Hernandez, M. V., Cano, M. J. R., Sanchez, M. A. G., Garrido-Lestache, E. B., Pinilla, J. M. G., de la Villa, B. G., Marques, R. B., Calvo, F. T., Perez-Martinez, M. T., Gracia-Rodenas, M. R., Garrido-Bravo, I. P., Pastor-Perez, F., Pascual-Figal, D. A., Molina, B. D., Orus, J., Gonzalo, F. E., Bertomeu, V., Valero, R., Martinez-Abellan, R., Quiles, J., Rodrigez-Ortega, J. A., Mateo, I., Elamrani, A., Fernandez-Vivancos, C., Valero, D. B., Almenar-Bonet, L., Sanchez-Lazaro, I. J., Marques-Sule, E., Facila-Rubio, L., Perez-Silvestre, J., Garcia-Gonzalez, P., Ridocci-Soriano, F., Garcia-Escriva, D., Pellicer-Cabo, A., de la Fuente Galan, L., Diaz, J. L., Platero, A. R., Arias, J. C., Blasco-Peiro, T., Julve, M. S., Sanchez-Insa, E., Aured-Guallar, C., Portoles-Ocampo, A., Melin, M., Hagglund, E., Stenberg, A., Lindahl, I. -M., Asserlund, B., Olsson, L., Afzelius, M., Karlstrom, P., Tengvall, L., Olsson, B., Kalayci, S., Cavusoglu, Y., Gencer, E., Yilmaz, M. B., Gunes, H., Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM), Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Université de Lorraine (UL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], French-Clinical Research Infrastructure Network - F-CRIN [Paris] (Cardiovascular & Renal Clinical Trialists - CRCT ), University of Ljubljana, University of A Coruña (UDC), EURObservational Research Programme, European Society of Cardiology, Cardiac Department, G. da Saliceto Hospital, AUSL Piacenza, National and Kapodistrian University of Athens (NKUA), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS San Raffaele Pisana), Karolinska Institutet [Stockholm], Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Berlin-Brandenburg Center for Regenerative Medicine [Berlin, Germany] (BCRT), University hospital of Zurich [Zurich], Marqueurs cardiovasculaires en situation de stress (MASCOT (UMR_S_942 / U942)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Université Sorbonne Paris Nord, Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), King's College Hospital (KCH), Hospital de Manacor, Università degli Studi dell'Aquila (UNIVAQ), ANMCO Research Center, Firenze,Italy, Since the start of EORP, the following companies have supported the programme: Abbott Vascular Int. (2011-2021), Amgen Cardiovascular (2009-2018), AstraZeneca (2014-2021), Bayer AG (2009-2018), Boehringer Ingelheim (2009-2019), Boston Scientific (2009-2012), The Bristol Myers Squibb and Pfizer Alliance (2011-2019), Daiichi Sankyo Europe GmbH (2011-2020), The Alliance Daiichi Sankyo Europe GmbH and Eli Lilly and Company (2014-2017), Edwards (2016-2019), Gedeon Richter Plc. (2014-2016), Menarini Int. Op. (2009-2012), MSD-Merck & Co. (2011-2014), Novartis Pharma AG (2014-2020), ResMed (2014-2016), Sanofi (2009-2011), SERVIER (2009-2018), Vifor (2019-2022)., Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), and Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)
- Subjects
medicine.medical_specialty ,Angiotensin receptor ,Angiotensins ,Prognosi ,Angiotensin-Converting Enzyme Inhibitors ,Heart failure ,610 Medicine & health ,030204 cardiovascular system & hematology ,Hyperkalaemia ,Hypokalaemia ,Mineralocorticoid receptor antagonists ,Prognosis ,Renin–angiotensin–aldosterone system inhibitors ,2705 Cardiology and Cardiovascular Medicine ,Angiotensin Receptor Antagonists ,03 medical and health sciences ,0302 clinical medicine ,Mineralocorticoid receptor ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Internal medicine ,Renin ,Renin–angiotensin system ,Humans ,Medicine ,Registries ,cardiovascular diseases ,Risk factor ,Aldosterone ,Ejection fraction ,business.industry ,Mineralocorticoid receptor antagonist ,Renin-angiotensin-aldosterone system inhibitors ,medicine.disease ,3. Good health ,Discontinuation ,Cardiology ,10209 Clinic for Cardiology ,Hyperkalemia ,Cardiology and Cardiovascular Medicine ,business ,Lower mortality - Abstract
[Abstract] Aims. We assessed the interplay between hyperkalaemia (HK) and renin–angiotensin–aldosterone system inhibitor (RAASi) use, dose and discontinuation, and their association with all‐cause or cardiovascular death in patients with chronic heart failure (HF). We hypothesized that HK‐associated increased death may be related to RAASi withdrawal. Methods and results. The ESC‐HFA‐EORP Heart Failure Long‐Term Registry was used. Among 9222 outpatients (HF with reduced ejection fraction: 60.6%, HF with mid‐range ejection fraction: 22.9%, HF with preserved ejection fraction: 16.5%) from 31 countries, 16.6% had HK (≥5.0 mmol/L) at baseline. Angiotensin‐converting enzyme inhibitor (ACEi) or angiotensin receptor blocker (ARB) was used in 88.3%, a mineralocorticoid receptor antagonist (MRA) in 58.7%, or a combination in 53.2%; of these, at ≥50% of target dose in ACEi: 61.8%; ARB: 64.7%; and MRA: 90.3%. At a median follow‐up of 12.2 months, there were 789 deaths (8.6%). Both hypokalaemia and HK were independently associated with higher mortality, and ACEi/ARB prescription at baseline with lower mortality. MRA prescription was not retained in the model. In multivariable analyses, HK at baseline was independently associated with MRA non‐prescription at baseline and subsequent discontinuation. When considering subsequent discontinuation of RAASi (instead of baseline use), HK was no longer found associated with all‐cause deaths. Importantly, all RAASi (ACEi, ARB, or MRA) discontinuations were strongly associated with mortality. Conclusions. In HF, hyper‐ and hypokalaemia were associated with mortality. However, when adjusting for RAASi discontinuation, HK was no longer associated with mortality, suggesting that HK may be a risk marker for RAASi discontinuation rather than a risk factor for worse outcomes. Funding for open access charge: Universidad de Granada / CBUA. The work was funded by the Courel Mountains UGGp
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- 2020
20. Association between loop diuretic dose changes and outcomes in chronic heart failure: observations from the ESC-EORP Heart Failure Long-Term Registry
- Author
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Gonzalez-Segovia, A. Briceno, A. Subias, P.E. Cano, M.J.R. Sanchez, M.A.G. Jimenez, J.F.D. Pinilla, J.M.G. de la Villa, B.G. Sahuquillo, A. Marques, R.B. Calvo, F.T. Perez-Martinez, M.T. Garrido-Bravo, I.P. Pastor-Perez, F. Pascual-Figal, D.A. Molina, B.D. Orus, J. Gonzalo, F.E. Bertomeu, V. Valero, R. Martinez-Abellan, R. Quiles, J. Mateo, I. ElAmrani, A. Fernandez-Vivancos, C. Valero, D.B. Almenar-Bonet, L. Sanchez-Lazaro, I.J. Marques-Sule, E. Facila-Rubio, L. Perez-Silvestre, J. Garcia-Gonzalez, P. Garcia-Escriva, D. Pellicer-Cabo, A. de laFuente Galan, L. Diaz, J.L. Platero, A.R. Arias, J.C. Blasco-Peiro, T. Julve, M.S. Sanchez-Insa, E. Portoles-Ocampo, A. Melin, M. Hägglund Lindahl, I.-M. Asserlund, B. Olsson, L. Dahlström, U. Afzelius, M. Karlström, P. Tengvall, L. Olsson, B. Kalayci, S. Cavusoglu, Y. Gencer, E. Yilmaz, M.B. Gunes, H.
- Abstract
Aims: Guidelines recommend down-titration of loop diuretics (LD) once euvolaemia is achieved. In outpatients with heart failure (HF), we investigated LD dose changes in daily cardiology practice, agreement with guideline recommendations, predictors of successful LD down-titration and association between dose changes and outcomes. Methods and results: We included 8130 HF patients from the ESC-EORP Heart Failure Long-Term Registry. Among patients who had dose decreased, successful decrease was defined as the decrease not followed by death, HF hospitalization, New York Heart Association class deterioration, or subsequent increase in LD dose. Mean age was 66 ± 13 years, 71% men, 62% HF with reduced ejection fraction, 19% HF with mid-range ejection fraction, 19% HF with preserved ejection fraction. Median [interquartile range (IQR)] LD dose was 40 (25–80) mg. LD dose was increased in 16%, decreased in 8.3% and unchanged in 76%. Median (IQR) follow-up was 372 (363–419) days. Diuretic dose increase (vs. no change) was associated with HF death [hazard ratio (HR) 1.53, 95% confidence interval (CI) 1.12–2.08; P = 0.008] and nominally with cardiovascular death (HR 1.25, 95% CI 0.96–1.63; P = 0.103). Decrease of diuretic dose (vs. no change) was associated with nominally lower HF (HR 0.59, 95% CI 0.33–1.07; P = 0.083) and cardiovascular mortality (HR 0.62,. 95% CI 0.38–1.00; P = 0.052). Among patients who had LD dose decreased, systolic blood pressure [odds ratio (OR) 1.11 per 10 mmHg increase, 95% CI 1.01–1.22; P = 0.032], and absence of (i) sleep apnoea (OR 0.24, 95% CI 0.09–0.69; P = 0.008), (ii) peripheral congestion (OR 0.48, 95% CI 0.29–0.80; P = 0.005), and (iii) moderate/severe mitral regurgitation (OR 0.57, 95% CI 0.37–0.87; P = 0.008) were independently associated with successful decrease. Conclusion: Diuretic dose was unchanged in 76% and decreased in 8.3% of outpatients with chronic HF. LD dose increase was associated with worse outcomes, while the LD dose decrease group showed a trend for better outcomes compared with the no-change group. Higher systolic blood pressure, and absence of (i) sleep apnoea, (ii) peripheral congestion, and (iii) moderate/severe mitral regurgitation were independently associated with successful dose decrease. © 2020 European Society of Cardiology
- Published
- 2020
21. Association between loop diuretic dose changes and outcomes in chronic heart failure: observations from the ESC-EORP Heart Failure Long-Term Registry
- Author
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Kapelios, C. J., Laroche, C., Crespo-Leiro, M. G., Anker, S. D., Coats, A. J. S., Diaz-Molina, B., Filippatos, G., Lainscak, M., Maggioni, A. P., Mcdonagh, T., Mebazaa, A., Metra, M., Moura, B., Mullens, W., Piepoli, M. F., Rosano, G. M. C., Ruschitzka, F., Seferovic, P. M., Lund, L. H., Gale, C. P., Beleslin, B., Budaj, A., Chioncel, O., Dagres, N., Danchin, N., Erlinge, D., Emberson, J., Glikson, M., Gray, A., Kayikcioglu, M., Maggioni, A., Nagy, K. V., Nedoshivin, A., Petronio, A. -S., Roos-Hesselink, J., Wallentin, L., Zeymer, U., Crespo-Leiro, M., Anker, S., Coats, A., Ferrari, R., Goda, A., Diez, M., Fernandez, A., Fruhwald, F., Gatzov, P., Kurlianskaya, A., Hullin, R., Christodoulides, T., Hradec, J., Nielsen, O. W., Nedjar, R., Uuetoa, T., Jimenez, J. F. D., Harjola, V. -P., Logeart, D., Tousoulis, D., Milicic, D., Merkely, B., Amir, O., Shotan, A., Shafie, D., Mirrakhimov, E., Kavoliuniene, A., Erglis, A., Otljanska, M., Kostovska, E. S., Demarco, D. C., Drozdz, J., Fonseca, C., Dekleva, M., Dahlstrom, U., Goncalvesova, E., Estrago, V., Bajraktari, G., Auer, J., Ablasser, K., Dolze, T., Brandner, K., Gstrein, S., Poelzl, G., Moertl, D., Reiter, S., Muslibegovic, A., Vasilj, M., Fazlibegovic, E., Cesko, M., Zelenika, D., Palic, B., Pravdic, D., Cuk, D., Vitlianova, K., Katova, T., Kurteva, T., Kamenova, D., Antova, M., Krejci, J., Spinar, J., Krupicka, J., Malek, F., Hegarova, M., Lazarova, M., Monhart, Z., Hassanein, M., El Messiry, F., El Shazly, A. H., Elrakshy, Y., Youssef, A., Moneim, A. A., Noamany, M., Dayem, T. K. A., Farag, N., Halawa, S. I., Hamid, M. A., Saleh, A., Ebeid, H., Hanna, R., Louis, O., Enen, M. A., Ibrahim, B. S., Nasr, G., Elbahry, A., Sobhy, H., Ashmawy, M., Gouda, M., Aboleineen, W., Bernard, Y., Meneveau, N., Pillot, M., Morel, M., Seronde, M. -F., Schiele, F., Briand, F., Delahaye, F., Damy, T., Eicher, J. -C., de Groote, P., Fertin, M., Lamblin, N., Isnard, R., Thevenin, S., Hagege, A., Le Marcis, V., J. -F., Ly, Coisne, D., Lequeux, B., Le Moal, V., Mascle, S., Lotton, P., Behar, N., Donal, E., Ridard, C., Reynaud, A., Basquin, A., Bauer, F., Codjia, R., Galinier, M., Tourikis, P., Stavroula, M., Stefanadis, C., Chrysohoou, C., Kotrogiannis, I., Matzaraki, V., Karavidas, A., Tsitsinakis, G., Kapelios, C., Nanas, J., Kampouri, H., Nana, E., Kaldara, E., Eugenidou, A., Vardas, P., Saloustros, I., Tsaknakis, T., Evangelou, S., Tziourganou, H., Tsaroucha, A., Papadopoulou, A., Douras, A., Polgar, L., Kosztin, A., Nyolczas, N., Nagy, A. C., Halmosi, R., Elber, J., Fuhrmann, A. V., Romano, S., Marcon, S., Penco, M., Di Mauro, M., Lemme, E., Carubelli, V., Rovetta, R., Bulgari, M., Quinzani, F., Bosi, S., Schiavina, G., Squeri, A., Di Tano, G., Pirelli, S., Fucili, A., Passero, T., Musio, S., Di Biase, M., Correale, M., Salvemini, G., Brognoli, S., Zanelli, E., Giordano, A., Agostoni, P., Salvioni, E., Copelli, S., Modena, M. G., Valenti, C., Olaru, A., Bandino, S., Deidda, M., Mercuro, G., Marino, P. N., Di Ruocco, M. V., Piccinino, C., Parrinello, G., Licata, G., Torres, D., Giambanco, S., Busalacchi, S., Arrotti, S., Novo, S., Inciardi, R. M., Pieri, P., Galifi, M. A., Teresi, G., Buccheri, D., Minacapelli, A., Veniani, M., Frisinghelli, A., Priori, S. G., Cattaneo, S., Opasich, C., Gualco, A., Pagliaro, M., Mancone, M., Fedele, F., Cinque, A., Vellini, M., Scarfo, I., Romeo, F., Ferraiuolo, F., Sergi, D., Anselmi, M., Melandri, F., Leci, E., Iori, E., Bovolo, V., Frea, S., Bergerone, S., Botta, M., Canavosio, F. G., Gaita, F., Merlo, M., Cinquetti, M., Sinagra, G., Ramani, F., Fabris, E., Artico, J., Miani, D., Fresco, C., Daneluzzi, C., Proclemer, A., Cicoira, M., Zanolla, L., Marchese, G., Torelli, F., Vassanelli, C., Voronina, N., Tamakauskas, V., Smalinskas, V., Karaliute, R., Petraskiene, I., Rumbinaite, E., Brazyte-Ramanauskiene, R., Petraskiene, D., Sinkiewicz, W., Gilewski, W., Pietrzak, J., Orzel, T., Kardaszewicz, P., Lazorko-Piega, M., Mosakowska, K., Bellwon, J., Rynkiewicz, A., Raczak, G., Lewicka, E., Dabrowska-Kugacka, A., Bartkowiak, R., Wozakowska-Kaplon, B., Krzeminski, A., Zabojszcz, M., Grzegorzko, A., Bury, K., Nessler, J., Zalewski, J., Furman, A., Poliwczak, A., Bala, A., Zycinski, P., Rudzinska, M., Jankowski, L., Kasprzak, J. D., Michalak, L., Soska, K. W., Huziuk, I., Flis, P., Weglarz, J., Bodys, A., Grajek, S., Straburzynska-Migaj, E., Dankowski, R., Szymanowska, K., Szyszka, A., Nowicka, A., Samcik, M., Wolniewicz, L., Komorowska, K., Poprawa, I., Komorowska, E., Sajnaga, D., Zolbach, A., Abdulkarim, A. -F., Lauko-Rachocka, A., Kaminski, L., Kostka, A., Cichy, A., Ruszkowski, P., Splawski, M., Fitas, G., Szymczyk, A., Serwicka, A., Fiega, A., Zysko, D., Krysiak, W., Szabowski, S., Skorek, E., Pruszczyk, P., Bienias, P., Ciurzynski, M., Welnicki, M., Mamcarz, A., Folga, A., Zielinski, T., Rywik, T., Leszek, P., Sobieszczanska-Malek, M., Kozar-Kaminska, K., Komuda, K., Wisniewska, J., Tarnowska, A., Marchel, M., Opolski, G., Kaplon-Cieslicka, A., Gil, R. J., Mozenska, O., Gil, K., Pawlak, A., Michalek, A., Krzesinski, P., Piotrowicz, K., Stanczyk, A., Skrobowski, A., Ponikowski, P., Jankowska, E., Rozentryt, P., Polonski, L., Nowalany-Kozielska, E., Kuczaj, A., Kalarus, Z., Szulik, M., Klys, J., Prokop-Lewicka, G., Kleinrok, A., Tavaresaguiar, C., Ventosa, A., Pereira, S., Faria, R., Chin, J., Dejesus, I., Santos, R., Silva, P., Moreno, N., Lourenco, C., Pereira, A., Castro, A., Andrade, A., Oliveiraguimaraes, T., Martins, S., Placido, R., Lima, G., Brito, D., Francisco, A. R., Proenca, M., Araujo, I., Marques, F., Campelo, M., Silva-Cardoso, J., Rodrigues, J., Rangel, I., Martins, E., Peres, M., Marta, L., Severino, D., Durao, D., Leao, S., Magalhaes, P., Moreira, I., Ferreira, C., Araujo, C., Ferreira, A., Baptista, A., Radoi, M., Bicescu, G., Vinereanu, D., Sinescu, C. -J., Macarie, C., Popescu, R., Daha, I., Dan, G. -A., Stanescu, C., Dan, A., Craiu, E., Nechita, E., Christodorescu, R., Otasevic, P., Simeunovic, D., Ristic, A. D., Celic, V., Pavlovic-Kleut, M., Stojcevski, B., Pencic, B., Stevanovic, A., Andric, A., Simic, D., Asanin, M., Iric-Cupic, V., Jovic, M., Milanov, S., Mitic, V., Atanaskovic, V., Antic, S., Pavlovic, M., Stanojevic, D., Stoickov, V., Ilic, S., Deljaninilic, M., Petrovic, D., Stojsic, S., Kecojevic, S., Dodic, S., Adic, N. C., Cankovic, M., Stojiljkovic, J., Mihajlovic, B., Radin, A., Radovanovic, S., Krotin, M., Klabnik, A., Pernicky, M., Murin, J., Kovar, F., Kmec, J., Strasek, M., Iskra, M. S., Ravnikar, T., Suligoj, N. C., Fras, Z., Jug, B., Glavic, T., Losic, R., Bombek, M., Krunic, B., Horvat, S., Kovac, D., Rajtman, D., Letonja, M., Winkler, R., Melihen-Bartolic, C., Bartolic, A., Kladnik, M., Pusnik, C. S., Marolt, A., Klen, J., Drnovsek, B., Leskovar, B., Anguita, M. J. F., Gallegopage, J. C., Martinez, F. M. S., Andres, J., Bayes-Genis, A., Mirabet, S., Mendez, A., Garcia-Cosio, L., Leon, V., Gonzalez-Costello, J., Muntane, G., Garay, A., Alcade-Martinez, V., Fernandez, S. L., Rivera-Lopez, R., Fernandez-Alvarez, M., Serrano-Martinez, J. L., Grille-Cancela, Z., Marzoa-Rivas, R., Paniagua-Martin, M. J., Barge-Caballero, E., Gonzalez-Gallarza, R. D., Salvadormontanes, O., Manjavacas, A. M. I., Conde, A. C., Araujo, A., Soria, T., Gomez-Bueno, M., Cobo-Marcos, M., Alonso-Pulpon, L., Segoviacubero, J., Sayago, I., Gonzalez-Segovia, A., Briceno, A., Subias, P. E., Cano, M. J. R., Sanchez, M. A. G., Pinilla, J. M. G., de la Villa, B. G., Sahuquillo, A., Marques, R. B., Calvo, F. T., Perez-Martinez, M. T., Garrido-Bravo, I. P., Pastor-Perez, F., Pascual-Figal, D. A., Molina, B. D., Orus, J., Gonzalo, F. E., Bertomeu, V., Valero, R., Martinez-Abellan, R., Quiles, J., Mateo, I., Elamrani, A., Fernandez-Vivancos, C., Valero, D. B., Almenar-Bonet, L., Sanchez-Lazaro, I. J., Marques-Sule, E., Facila-Rubio, L., Perez-Silvestre, J., Garcia-Gonzalez, P., Garcia-Escriva, D., Pellicer-Cabo, A., de laFuente Galan, L., Diaz, J. L., Platero, A. R., Arias, J. C., Blasco-Peiro, T., Julve, M. S., Sanchez-Insa, E., Portoles-Ocampo, A., Melin, M., Hagglund, Stenberg, A., Lindahl, I. -M., Asserlund, B., Olsson, L., Afzelius, M., Karlstrom, P., Tengvall, L., Olsson, B., Kalayci, S., Cavusoglu, Y., Gencer, E., Yilmaz, M. B., Gunes, H., Kapelios, C. J., Laroche, C., Crespo-Leiro, M. G., Anker, S. D., Coats, A. J. S., Diaz-Molina, B., Filippatos, G., Lainscak, M., Maggioni, A. P., Mcdonagh, T., Mebazaa, A., Metra, M., Moura, B., Mullens, W., Piepoli, M. F., Rosano, G. M. C., Ruschitzka, F., Seferovic, P. M., Lund, L. H., Gale, C. P., Beleslin, B., Budaj, A., Chioncel, O., Dagres, N., Danchin, N., Erlinge, D., Emberson, J., Glikson, M., Gray, A., Kayikcioglu, M., Maggioni, A., Nagy, K. V., Nedoshivin, A., Petronio, A. -S., Roos-Hesselink, J., Wallentin, L., Zeymer, U., Crespo-Leiro, M., Anker, S., Coats, A., Ferrari, R., Goda, A., Diez, M., Fernandez, A., Fruhwald, F., Gatzov, P., Kurlianskaya, A., Hullin, R., Christodoulides, T., Hradec, J., Nielsen, O. W., Nedjar, R., Uuetoa, T., Jimenez, J. F. D., Harjola, V. -P., Logeart, D., Tousoulis, D., Milicic, D., Merkely, B., Amir, O., Shotan, A., Shafie, D., Mirrakhimov, E., Kavoliuniene, A., Erglis, A., Otljanska, M., Kostovska, E. S., Demarco, D. C., Drozdz, J., Fonseca, C., Dekleva, M., Dahlstrom, U., Goncalvesova, E., Estrago, V., Bajraktari, G., Auer, J., Ablasser, K., Dolze, T., Brandner, K., Gstrein, S., Poelzl, G., Moertl, D., Reiter, S., Muslibegovic, A., Vasilj, M., Fazlibegovic, E., Cesko, M., Zelenika, D., Palic, B., Pravdic, D., Cuk, D., Vitlianova, K., Katova, T., Kurteva, T., Kamenova, D., Antova, M., Krejci, J., Spinar, J., Krupicka, J., Malek, F., Hegarova, M., Lazarova, M., Monhart, Z., Hassanein, M., El Messiry, F., El Shazly, A. H., Elrakshy, Y., Youssef, A., Moneim, A. A., Noamany, M., Dayem, T. K. A., Farag, N., Halawa, S. I., Hamid, M. A., Saleh, A., Ebeid, H., Hanna, R., Louis, O., Enen, M. A., Ibrahim, B. S., Nasr, G., Elbahry, A., Sobhy, H., Ashmawy, M., Gouda, M., Aboleineen, W., Bernard, Y., Meneveau, N., Pillot, M., Morel, M., Seronde, M. -F., Schiele, F., Briand, F., Delahaye, F., Damy, T., Eicher, J. -C., de Groote, P., Fertin, M., Lamblin, N., Isnard, R., Thevenin, S., Hagege, A., Le Marcis, V., Ly, J. -F., Coisne, D., Lequeux, B., Le Moal, V., Mascle, S., Lotton, P., Behar, N., Donal, E., Ridard, C., Reynaud, A., Basquin, A., Bauer, F., Codjia, R., Galinier, M., Tourikis, P., Stavroula, M., Stefanadis, C., Chrysohoou, C., Kotrogiannis, I., Matzaraki, V., Karavidas, A., Tsitsinakis, G., Kapelios, C., Nanas, J., Kampouri, H., Nana, E., Kaldara, E., Eugenidou, A., Vardas, P., Saloustros, I., Tsaknakis, T., Evangelou, S., Tziourganou, H., Tsaroucha, A., Papadopoulou, A., Douras, A., Polgar, L., Kosztin, A., Nyolczas, N., Nagy, A. C., Halmosi, R., Elber, J., Fuhrmann, A. V., Romano, S., Marcon, S., Penco, M., Di Mauro, M., Lemme, E., Carubelli, V., Rovetta, R., Bulgari, M., Quinzani, F., Bosi, S., Schiavina, G., Squeri, A., Di Tano, G., Pirelli, S., Fucili, A., Passero, T., Musio, S., Di Biase, M., Correale, M., Salvemini, G., Brognoli, S., Zanelli, E., Giordano, A., Agostoni, P., Salvioni, E., Copelli, S., Modena, M. G., Valenti, C., Olaru, A., Bandino, S., Deidda, M., Mercuro, G., Marino, P. N., Di Ruocco, M. V., Piccinino, C., Parrinello, G., Licata, G., Torres, D., Giambanco, S., Busalacchi, S., Arrotti, S., Novo, S., Inciardi, R. M., Pieri, P., Galifi, M. A., Teresi, G., Buccheri, D., Minacapelli, A., Veniani, M., Frisinghelli, A., Priori, S. G., Cattaneo, S., Opasich, C., Gualco, A., Pagliaro, M., Mancone, M., Fedele, F., Cinque, A., Vellini, M., Scarfo, I., Romeo, F., Ferraiuolo, F., Sergi, D., Anselmi, M., Melandri, F., Leci, E., Iori, E., Bovolo, V., Frea, S., Bergerone, S., Botta, M., Canavosio, F. G., Gaita, F., Merlo, M., Cinquetti, M., Sinagra, G., Ramani, F., Fabris, E., Artico, J., Miani, D., Fresco, C., Daneluzzi, C., Proclemer, A., Cicoira, M., Zanolla, L., Marchese, G., Torelli, F., Vassanelli, C., Voronina, N., Tamakauskas, V., Smalinskas, V., Karaliute, R., Petraskiene, I., Rumbinaite, E., Brazyte-Ramanauskiene, R., Petraskiene, D., Sinkiewicz, W., Gilewski, W., Pietrzak, J., Orzel, T., Kardaszewicz, P., Lazorko-Piega, M., Mosakowska, K., Bellwon, J., Rynkiewicz, A., Raczak, G., Lewicka, E., Dabrowska-Kugacka, A., Bartkowiak, R., Wozakowska-Kaplon, B., Krzeminski, A., Zabojszcz, M., Grzegorzko, A., Bury, K., Nessler, J., Zalewski, J., Furman, A., Poliwczak, A., Bala, A., Zycinski, P., Rudzinska, M., Jankowski, L., Kasprzak, J. D., Michalak, L., Soska, K. W., Huziuk, I., Flis, P., Weglarz, J., Bodys, A., Grajek, S., Straburzynska-Migaj, E., Dankowski, R., Szymanowska, K., Szyszka, A., Nowicka, A., Samcik, M., Wolniewicz, L., Komorowska, K., Poprawa, I., Komorowska, E., Sajnaga, D., Zolbach, A., Abdulkarim, A. -F., Lauko-Rachocka, A., Kaminski, L., Kostka, A., Cichy, A., Ruszkowski, P., Splawski, M., Fitas, G., Szymczyk, A., Serwicka, A., Fiega, A., Zysko, D., Krysiak, W., Szabowski, S., Skorek, E., Pruszczyk, P., Bienias, P., Ciurzynski, M., Welnicki, M., Mamcarz, A., Folga, A., Zielinski, T., Rywik, T., Leszek, P., Sobieszczanska-Malek, M., Kozar-Kaminska, K., Komuda, K., Wisniewska, J., Tarnowska, A., Marchel, M., Opolski, G., Kaplon-Cieslicka, A., Gil, R. J., Mozenska, O., Gil, K., Pawlak, A., Michalek, A., Krzesinski, P., Piotrowicz, K., Stanczyk, A., Skrobowski, A., Ponikowski, P., Jankowska, E., Rozentryt, P., Polonski, L., Nowalany-Kozielska, E., Kuczaj, A., Kalarus, Z., Szulik, M., Klys, J., Prokop-Lewicka, G., Kleinrok, A., Tavaresaguiar, C., Ventosa, A., Pereira, S., Faria, R., Chin, J., Dejesus, I., Santos, R., Silva, P., Moreno, N., Lourenco, C., Pereira, A., Castro, A., Andrade, A., Oliveiraguimaraes, T., Martins, S., Placido, R., Lima, G., Brito, D., Francisco, A. R., Proenca, M., Araujo, I., Marques, F., Campelo, M., Silva-Cardoso, J., Rodrigues, J., Rangel, I., Martins, E., Peres, M., Marta, L., Severino, D., Durao, D., Leao, S., Magalhaes, P., Moreira, I., Ferreira, C., Araujo, C., Ferreira, A., Baptista, A., Radoi, M., Bicescu, G., Vinereanu, D., Sinescu, C. -J., Macarie, C., Popescu, R., Daha, I., Dan, G. -A., Stanescu, C., Dan, A., Craiu, E., Nechita, E., Christodorescu, R., Otasevic, P., Simeunovic, D., Ristic, A. D., Celic, V., Pavlovic-Kleut, M., Stojcevski, B., Pencic, B., Stevanovic, A., Andric, A., Simic, D., Asanin, M., Iric-Cupic, V., Jovic, M., Milanov, S., Mitic, V., Atanaskovic, V., Antic, S., Pavlovic, M., Stanojevic, D., Stoickov, V., Ilic, S., Deljaninilic, M., Petrovic, D., Stojsic, S., Kecojevic, S., Dodic, S., Adic, N. C., Cankovic, M., Stojiljkovic, J., Mihajlovic, B., Radin, A., Radovanovic, S., Krotin, M., Klabnik, A., Pernicky, M., Murin, J., Kovar, F., Kmec, J., Strasek, M., Iskra, M. S., Ravnikar, T., Suligoj, N. C., Fras, Z., Jug, B., Glavic, T., Losic, R., Bombek, M., Krunic, B., Horvat, S., Kovac, D., Rajtman, D., Letonja, M., Winkler, R., Melihen-Bartolic, C., Bartolic, A., Kladnik, M., Pusnik, C. S., Marolt, A., Klen, J., Drnovsek, B., Leskovar, B., Anguita, M. J. F., Gallegopage, J. C., Martinez, F. M. S., Andres, J., Bayes-Genis, A., Mirabet, S., Mendez, A., Garcia-Cosio, L., Leon, V., Gonzalez-Costello, J., Muntane, G., Garay, A., Alcade-Martinez, V., Fernandez, S. L., Rivera-Lopez, R., Fernandez-Alvarez, M., Serrano-Martinez, J. L., Grille-Cancela, Z., Marzoa-Rivas, R., Paniagua-Martin, M. J., Barge-Caballero, E., Gonzalez-Gallarza, R. D., Salvadormontanes, O., Manjavacas, A. M. I., Conde, A. C., Araujo, A., Soria, T., Gomez-Bueno, M., Cobo-Marcos, M., Alonso-Pulpon, L., Segoviacubero, J., Sayago, I., Gonzalez-Segovia, A., Briceno, A., Subias, P. E., Cano, M. J. R., Sanchez, M. A. G., Pinilla, J. M. G., de la Villa, B. G., Sahuquillo, A., Marques, R. B., Calvo, F. T., Perez-Martinez, M. T., Garrido-Bravo, I. P., Pastor-Perez, F., Pascual-Figal, D. A., Molina, B. D., Orus, J., Gonzalo, F. E., Bertomeu, V., Valero, R., Martinez-Abellan, R., Quiles, J., Mateo, I., Elamrani, A., Fernandez-Vivancos, C., Valero, D. B., Almenar-Bonet, L., Sanchez-Lazaro, I. J., Marques-Sule, E., Facila-Rubio, L., Perez-Silvestre, J., Garcia-Gonzalez, P., Garcia-Escriva, D., Pellicer-Cabo, A., de laFuente Galan, L., Diaz, J. L., Platero, A. R., Arias, J. C., Blasco-Peiro, T., Julve, M. S., Sanchez-Insa, E., Portoles-Ocampo, A., Melin, M., Hagglund, Stenberg, A., Lindahl, I. -M., Asserlund, B., Olsson, L., Afzelius, M., Karlstrom, P., Tengvall, L., Olsson, B., Kalayci, S., Cavusoglu, Y., Gencer, E., Yilmaz, M. B., Gunes, H., University of Zurich, and Kapelios, Chris J
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medicine.medical_specialty ,medicine.drug_class ,medicine.medical_treatment ,610 Medicine & health ,030204 cardiovascular system & hematology ,2705 Cardiology and Cardiovascular Medicine ,Loop diuretics ,03 medical and health sciences ,0302 clinical medicine ,Interquartile range ,Furosemide ,Internal medicine ,medicine ,Loop diuretic ,Mortality ,Ejection fraction ,business.industry ,Hazard ratio ,medicine.disease ,Prognosis ,Chronic heart failure ,3. Good health ,Blood pressure ,Heart failure ,Drug titration ,10209 Clinic for Cardiology ,Cardiology ,Diuretic ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Abstract
[Abstract] Aims. Guidelines recommend down-titration of loop diuretics (LD) once euvolaemia is achieved. In outpatients with heart failure (HF), we investigated LD dose changes in daily cardiology practice, agreement with guideline recommendations, predictors of successful LD down-titration and association between dose changes and outcomes. Methods and results. We included 8130 HF patients from the ESC-EORP Heart Failure Long-Term Registry. Among patients who had dose decreased, successful decrease was defined as the decrease not followed by death, HF hospitalization, New York Heart Association class deterioration, or subsequent increase in LD dose. Mean age was 66±13 years, 71% men, 62% HF with reduced ejection fraction, 19% HF with mid-range ejection fraction, 19% HF with preserved ejection fraction. Median [interquartile range (IQR)] LD dose was 40 (25–80) mg. LD dose was increased in 16%, decreased in 8.3% and unchanged in 76%. Median (IQR) follow-up was 372 (363–419) days. Diuretic dose increase (vs. no change) was associated with HF death [hazard ratio (HR) 1.53, 95% confidence interval (CI) 1.12–2.08; P = 0.008] and nominally with cardiovascular death (HR 1.25, 95% CI 0.96–1.63; P = 0.103). Decrease of diuretic dose (vs. no change) was associated with nominally lower HF (HR 0.59, 95% CI 0.33–1.07; P = 0.083) and cardiovascular mortality (HR 0.62 95% CI 0.38–1.00; P = 0.052). Among patients who had LD dose decreased, systolic blood pressure [odds ratio (OR) 1.11 per 10 mmHg increase, 95% CI 1.01–1.22; P = 0.032], and absence of (i) sleep apnoea (OR 0.24, 95% CI 0.09–0.69; P = 0.008), (ii) peripheral congestion (OR 0.48, 95% CI 0.29–0.80; P = 0.005), and (iii) moderate/severe mitral regurgitation (OR 0.57, 95% CI 0.37–0.87; P = 0.008) were independently associated with successful decrease. Conclusion. Diuretic dose was unchanged in 76% and decreased in 8.3% of outpatients with chronic HF. LD dose increase was associated with worse outcomes, while the LD dose decrease group showed a trend for better outcomes compared with the no-change group. Higher systolic blood pressure, and absence of (i) sleep apnoea, (ii) peripheral congestion, and (iii) moderate/severe mitral regurgitation were independently associated with successful dose decrease.
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- 2020
22. Thromboembolic events in peripartum cardiomyopathy: Results from the ESC EORP PPCM registry.
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Tromp, Jasper, Jackson, Alice M., Abdelhamid, Magdy, Fouad, Doaa, Youssef, Ghada, Petrie, Mark C., Bauersachs, Johann, Sliwa, Karen, van der Meer, Peter, Gale, C.P., Beleslin, B., Budaj, A., Chioncel, O., Dagres, N., Danchin, N., Emberson, J., Erlinge, D., Glikson, M., Gray, A., and Kayikcioglu, M.
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PERIPARTUM cardiomyopathy ,THROMBOEMBOLISM ,SYMPTOMS ,PERINATAL period ,MEDICAL research - Abstract
Of 749 women with baseline data on TE, 41 (5.5%) had a TE at the time of PPCM diagnosis ( I Figure i 1A), 1.1% had a stroke, 1.7% an arterial TE and 4.2% a venous TE. The most common causes of death were HF and stroke (each accounting for 40% of deaths) in women with TE compared with HF in women without TE (41% due to HF, 33% sudden). Peripartum cardiomyopathy (PPCM) is a form of heart failure (HF) that develops towards the end of pregnancy or within the first months after delivery.[1] Rates of thromboembolism in PPCM are reportedly higher than in many other cardiomyopathies.[2] In the United States, thromboembolism was the most common serious complication in PPCM, occurring in 6.6% of affected women.[3] In the multinational European Society of Cardiology (ESC) EURObservational Research Programme (EORP) PPCM registry, 5% of patients had a thromboembolic event (TE) during the index hospitalization.[4] The peripartum period is a hypercoagulative phase, an evolutionary remnant to minimize postpartum haemorrhage.[5] The combination of left ventricular (LV) dilatation, endothelial injury, immobility, and postpartum hypercoagulable state, may explain the high prevalence of TE in women with PPCM. [Extracted from the article]
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- 2023
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23. Clinical phenotypes of acute heart failure based on signs and symptoms of perfusion and congestion at emergency department presentation and their relationship with patient management and outcomes
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Javaloyes, P., Miro, O., Gil, V., Martin-Sanchez, F.J., Jacob, J., Herrero, P., Takagi, K., Alquezar-Arbe, A., Diez, M.P.L., Martin, E., Bibiano, C., Escoda, R., Gil, C., Fuentes, M., Garcia, G.L., Perez, J.M.A., Jerez, A., Tost, J., Llauger, L., Romero, R., Garrido, J.M., Rodriguez-Adrada, E., Sanchez, C., Rossello, X., Parissis, J., Mebazaa, A., Chioncel, O., Llorens, P., Alonso, H., Perez-Llantada, E., Cadenas, M.S., Xipell, C., Perez-Dura, M.J., Salvo, E., Pavon, J., Noval, A., Torres, J.M., Lopez-Grima, M.L., Valero, A., Juan, M.A., Aguirre, A., Pedragosa, M.A., Maso, S.M., Alonso, M.I., Ruiz, F., Franco, J.M., Mecina, A.B., Berenguer, M., Donea, R., Ramon, S.S., Rodriguez, V.C., Pinera, P., Nicolas, J.A.S., Garate, R.T., Rizzi, M.A., Herrera, S., Cabello, I., Haro, A., Richard, F., Alvarez, J.V., Garcia, B.P., Garcia, M.G., Gonzalez, M.S., Marquina, V., Jimenez, I., Hernandez, N., Brouzet, B., Espinosa, B., Andueza, J.A., Ruiz, M., Calvache, R., Serralta, M.T.L., Jave, L.E.C., Amores Arriaga, B., Bergua, B.S., Mojarro, E.M., Jimenez, B.S.A., Becquer, L.T., Burillo, G., Garcia, L.L., LaSalle, G.C., Urbano, C.A., Soto, A.B.G., Padial, E.D., Ferrer, E.S., Lucas-Imbernon, F.J., Gaya, R., Mir, M., Rodriguez, B., Carballo, J.L., and Miranda, B.R.
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Perfusion ,Acute heart failure, Clinical profiles, Congestion, Emergency department, Perfusion ,Clinical profiles ,Emergency department ,Congestion ,Acute heart failure ,humanities - Abstract
Objective To compare the clinical characteristics and outcomes of patients with acute heart failure (AHF) according to clinical profiles based on congestion and perfusion determined in the emergency department (ED). Methods and results Overall, 11 261 unselected AHF patients from 41 Spanish EDs were classified according to perfusion (normoperfusion = warm; hypoperfusion = cold) and congestion (not = dry; yes = wet). Baseline and decompensation characteristics were recorded as were the main wards to which patients were admitted. The primary outcome was 1-year all-cause mortality; secondary outcomes were need for hospitalisation during the index AHF event, in-hospital all-cause mortality, prolonged hospitalisation, 7-day post-discharge ED revisit for AHF and 30-day post-discharge rehospitalisation for AHF. A total of 8558 patients (76.0%) were warm+ wet, 1929 (17.1%) cold+ wet, 675 (6.0%) warm+ dry, and 99 (0.9%) cold+ dry; hypoperfused (cold) patients were more frequently admitted to intensive care units and geriatrics departments, and warm+ wet patients were discharged home without admission. The four phenotypes differed in most of the baseline and decompensation characteristics. The 1-year mortality was 30.8%, and compared to warm+ dry, the adjusted hazard ratios were significantly increased for cold+ wet (1.660; 95% confidence interval 1.400-1.968) and cold+ dry (1.672; 95% confidence interval 1.189-2.351). Hypoperfused (cold) phenotypes also showed higher rates of index episode hospitalisation and in-hospital mortality, while congestive (wet) phenotypes had a higher risk of prolonged hospitalisation but decreased risk of rehospitalisation. No differences were observed among phenotypes in ED revisit risk. Conclusions Bedside clinical evaluation of congestion and perfusion of AHF patients upon ED arrival and classification according to phenotypic profiles proposed by the latest European Society of Cardiology guidelines provide useful complementary information and help to rapidly predict patient outcomes shortly after ED patient arrival.
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- 2021
24. Poster session 3: Thursday 4 December 2014, 14: 00–18: 00Location: Poster area
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Savu, O, Carstea, N, Stoica, E, Macarie, C, Moldovan, H, Iliescu, V, and Chioncel, O
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- 2014
25. Factors associated with in-hospital mortality and adverse outcomes during the vulnerable post-discharge phase after the first episode of acute heart failure: results of the NOVICA-2 study (Sept, 10.1007/s12170-012-0259-8, 2020)
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Rizzi, M, Sarasola, A, Arbe, A, Mateo, S, Gil, V, Llorens, P, Jacob, J, Martin-Sanchez, F, Puente, P, Escoda, R, Espinosa, B, Roset, A, Torres-Garate, R, Torres-Murillo, J, Mecina, A, Lopez-Diez, M, Perez, J, Tost, J, Salvo, E, Lopez-Grima, M, Gil, C, Mir, M, Ruschitzka, F, Chioncel, O, Miro, O, and ICA-SEMES Research Group
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- 2021
26. Patient profiling in heart failure for tailoring medical therapy. A consensus document of the Heart Failure Association of the European Society of Cardiology
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Rosano, G.M.C. Moura, B. Metra, M. Böhm, M. Bauersachs, J. Ben Gal, T. Adamopoulos, S. Abdelhamid, M. Bistola, V. Čelutkienė, J. Chioncel, O. Farmakis, D. Ferrari, R. Filippatos, G. Hill, L. Jankowska, E.A. Jaarsma, T. Jhund, P. Lainscak, M. Lopatin, Y. Lund, L.H. Milicic, D. Mullens, W. Pinto, F. Ponikowski, P. Savarese, G. Thum, T. Volterrani, M. Anker, S.D. Seferovic, P.M. Coats, A.J.S.
- Abstract
Despite guideline recommendations and available evidence, implementation of treatment in heart failure (HF) is poor. The majority of patients are not prescribed drugs at target doses that have been proven to positively impact morbidity and mortality. Among others, tolerability issues related to low blood pressure, heart rate, impaired renal function or hyperkalaemia are responsible. Chronic kidney disease plays an important role as it affects up to 50% of patients with HF. Also, dynamic changes in estimated glomerular filtration rate may occur during the course of HF, resulting in inappropriate dose reduction or even discontinuation of decongestive or neurohormonal modulating therapy in clinical practice. As patients with HF are rarely naïve to pharmacologic therapies, the challenge is to adequately prioritize or select the most appropriate up-titration schedule according to patient profile. In this consensus document, we identified nine patient profiles that may be relevant for treatment implementation in HF patients with a reduced ejection fraction. These profiles take into account heart rate (70 bpm), the presence of atrial fibrillation, symptomatic low blood pressure, estimated glomerular filtration rate (30 mL/min/1.73 m2) or hyperkalaemia. The pre-discharge patient, frequently still congestive, is also addressed. A personalized approach, adjusting guideline-directed medical therapy to patient profile, may allow to achieve a better and more comprehensive therapy for each individual patient than the more traditional, forced titration of each drug class before initiating treatment with the next. © 2021 European Society of Cardiology
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- 2021
27. Synergistic Impact of Systolic Blood Pressure and Perfusion Status on Mortality in Acute Heart Failure
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Rossello, X, Bueno, H, Gil, V, Jacob, J, Martin-Sanchez, FJ, Llorens, P, Puente, PH, Alquezar-Arbe, A, Espinosa, B, Raposeiras-Roubin, S, Muller, CE, Mebazaa, A, Maggioni, AP, Pocock, S, Chioncel, O, Miro, O, and ICA-SEMES Res Grp
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blood pressure ,heart failure ,prognosis ,mortality - Abstract
Background: Physical examination remains the cornerstone in the assessment of acute heart failure. There is a lack of adequately powered studies assessing the combined impact of both systolic blood pressure (SBP) and hypoperfusion on short-term mortality. Methods: Patients with acute heart failure from 41 Spanish emergency departments were recruited consecutively in 3 time periods between 2011 and 2016. Logistic regression models were used to assess the association of 30-day mortality with SBP (= 130 mm Hg) and with manifestations of hypoperfusion (cold skin, cutaneous pallor, delayed capillary refill, livedo reticularis, and mental confusion) at admission. Results: Among 10 979 patients, 1143 died within the first 30 days (10.2%). There was an inverse association between 30-day mortality and initial SBP (35.4%, 18.9%, 12.4%, and 7.5% for SBP= 130 mm Hg, respectively; P= 2 signs/symptoms of hypoperfusion, respectively; P= 130 mm Hg (odds ratio [OR]=1.03 [95% CI, 0.77-1.36] and OR=1.18 [95% CI, 0.86-1.62] for 1 and >= 2 compared with 0 manifestations of hypoperfusion), SBP 110 to 129 mm Hg (OR=1.23 [95% CI, 0.86-1.77] and OR=2.18 [95% CI, 1.44-3.31], respectively), SBP 90 to 109 mm Hg (OR=1.29 [95% CI, 0.79-2.10] and OR=2.24 [95% CI, 1.36-3.66], respectively), and SBP
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- 2021
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28. Outcomes of patients with heart failure with preserved ejection fraction discharged on treatment with neurohormonal antagonists after an episode of decompensation
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Tost J, Llorens P, Cotter G, Davison B, Jacob J, Gil V, Herrero P, Martin-Sanchez F, Donea R, Rodriguez B, Lucas-Imbernon F, Andueza J, Mecina A, Torres-Garate R, Pinera P, Alquezar-Arbe A, Espinosa B, Mebazaa A, Chioncel O, Miro O, and ICA-SEMES Grp
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Antineurohormonal drugs ,Acute heart failure ,Preserved ejection fraction ,Prognosis ,Emergency departments - Abstract
Aims: To analyze the frequency with which patients with heart failure with preserved ejection fraction (HFpEF) discharged after an acute heart failure (AHF) episode are treated with antineurohormonal drugs (ANHD), the variables related to ANHD prescription and their relationship with outcomes. Methods: We included consecutive HFpEF patients (left ventricular ejection fraction >= 50%) discharged after an AHF episode from 45 Spanish hospitals whose chronic medications and treatment at discharge were available. Patients were classified according to whether they were discharged with or without ANHD, including beta-blockers (BB), renin-angiotensin-aldosterone-system inhibitors (RAASi) and mineralcorticosteroid-receptor antagonists (MRA). Co-primary outcomes consisted of 1-year all-cause mortality and 90-day combined adverse event (revisit to emergency department -ED-, hospitalization due to AHF or all-cause death). Secondary outcomes were 90-day adverse events taken individually. Adjusted associations of ANHD treatment with outcomes were calculated. Results: We analyzed 3,305 patients with HFpEF (median age: 83, 60% women), 2,312 (70%) discharged with ANHD. The ANHD most frequently prescribed was BB (45.8%). The 1-year mortality was 26.9% (adjusted HR for ANHD patients:1.17, 95%CI=0.98-1.38) and the 90-day combined adverse event was 54.4% (HR=1.14, 95% CI=0.99-1.31). ED revisit was significantly increased by ANHD (HR=1.15, 95%CI=1.01-1.32). MRA and BB were associated with worse results in some co-primary or secondary endpoints, while RAASi (alone) reduced 90-day hospitalization (HR=0.73, 98%CI=0.56-0.96). Conclusion: 70% of HFpEF patients are discharged with ANHD after an AHF episode. ANHD do not seem to reduce mortality or adverse events in HFpEF patients, only RAASi could provide some benefits, reducing the risk of hospitalization for AHF.
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- 2021
29. The FAST-FURO study: effect of very early administration of intravenous furosemide in the prehospital setting to patients with acute heart failure attending the emergency department
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Miró Ò, Harjola P, Rossello X, Gil V, Jacob J, Llorens P, Martín-Sánchez FJ, Herrero P, Martínez-Nadal G, Aguiló S, López-Grima ML, Fuentes M, Álvarez Pérez JM, Rodríguez-Adrada E, Mir M, Tost J, Llauger L, Ruschitzka F, Harjola VP, Mullens W, Masip J, Chioncel O, Peacock WF, Müller C, Mebazaa A, ICA-SEMES Research Group, and University of Zurich
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medicine.medical_specialty ,Emergency Medical Services ,New York Heart Association Class ,610 Medicine & health ,030204 cardiovascular system & hematology ,Critical Care and Intensive Care Medicine ,03 medical and health sciences ,0302 clinical medicine ,Furosemide ,Internal medicine ,Epidemiology ,medicine ,Emergency medical services ,Humans ,030212 general & internal medicine ,Mortality ,Original Scientific Papers ,Diuretics ,Outcome ,Heart Failure ,business.industry ,Emergency department ,Acute heart failure ,Atrial fibrillation ,General Medicine ,Odds ratio ,medicine.disease ,3. Good health ,Heart failure ,Acute Disease ,10209 Clinic for Cardiology ,Cardiology and Cardiovascular Medicine ,business ,Emergency Service, Hospital ,medicine.drug - Abstract
Aims The effect of early administration of intravenous (IV) furosemide in the emergency department (ED) on short-term outcomes of acute heart failure (AHF) patients remains controversial, with one recent Japanese study reporting a decrease of in-hospital mortality and one Korean study reporting a lack of clinical benefit. Both studies excluded patients receiving prehospital IV furosemide and only included patients requiring hospitalization. To assess the impact on short-term outcomes of early IV furosemide administration by emergency medical services (EMS) before patient arrival to the ED. Methods and results In a secondary analysis of the Epidemiology of Acute Heart Failure in Emergency Departments (EAHFE) registry of consecutive AHF patients admitted to Spanish EDs, patients treated with IV furosemide at the ED were classified according to whether they received IV furosemide from the EMS (FAST-FURO group) or not (CONTROL group). In-hospital all-cause mortality, 30-day all-cause mortality, and prolonged hospitalization (>10 days) were assessed. We included 12 595 patients (FAST-FURO = 683; CONTROL = 11 912): 968 died during index hospitalization [7.7%; FAST-FURO = 10.3% vs. CONTROL = 7.5%; odds ratio (OR) = 1.403, 95% confidence interval (95% CI) = 1.085–1.813; P = 0.009], 1269 died during the first 30 days (10.2%; FAST-FURO = 13.4% vs. CONTROL = 9.9%; OR = 1.403, 95% CI = 1.146–1.764; P = 0.004), and 2844 had prolonged hospitalization (22.8%; FAST-FURO = 25.8% vs. CONTROL = 22.6%; OR = 1.189, 95% CI = 0.995–1.419; P = 0.056). FAST-FURO group patients had more diabetes mellitus, ischaemic cardiomyopathy, peripheral artery disease, left ventricular systolic dysfunction, and severe decompensations, and had a better New York Heart Association class and had less atrial fibrillation. After adjusting for these significant differences, early IV furosemide resulted in no impact on short-term outcomes: OR = 1.080 (95% CI = 0.817–1.427) for in-hospital mortality, OR = 1.086 (95% CI = 0.845–1.396) for 30-day mortality, and OR = 1.095 (95% CI = 0.915–1.312) for prolonged hospitalization. Several sensitivity analyses, including analysis of 599 pairs of patients matched by propensity score, showed consistent findings. Conclusion Early IV furosemide during the prehospital phase was administered to the sickest patients, was not associated with changes in short-term mortality or length of hospitalization after adjustment for several confounders.
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- 2021
30. The FAST-FURO study: effect of very early administration of intravenous furosemide in the prehospital setting to patients with acute heart failure attending the emergency department
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Miro, O, Harjola, P, Rossello, X, Gil, V, Jacob, J, Llorens, P, Martin-Sanchez, FJ, Herrero, P, Martinez-Nadal, G, Aguilo, S, Lopez-Grima, ML, Fuentes, M, Perez, JMA, Rodriguez-Adrada, E, Mir, M, Tost, J, Llauger, L, Ruschitzka, F, Harjola, VP, Mullens, W, Masip, J, Chioncel, O, Peacock, WF, Muller, C, Mebazaa, A, Alquezar A., Rizzi M.A., Herrera S., and ICA-SEMES Res Grp
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Furosemide ,Emergency department ,Acute heart failure ,Mortality ,Diuretics ,Outcome - Abstract
Aims The effect of early administration of intravenous (IV) furosemide in the emergency department (ED) on short-term outcomes of acute heart failure (AHF) patients remains controversial, with one recent Japanese study reporting a decrease of in-hospital mortality and one Korean study reporting a lack of clinical benefit. Both studies excluded patients receiving prehospital IV furosemide and only included patients requiring hospitalization. To assess the impact on short-term outcomes of early IV furosemide administration by emergency medical services (EMS) before patient arrival to the ED. Methods and results In a secondary analysis of the Epidemiology of Acute Heart Failure in Emergency Departments (EAHFE) registry of consecutive AHF patients admitted to Spanish EDs, patients treated with IV furosemide at the ED were classified according to whether they received IV furosemide from the EMS (FAST-FURO group) or not (CONTROL group). In-hospital all-cause mortality, 30-day all-cause mortality, and prolonged hospitalization (>10 days) were assessed. We included 12 595 patients (FAST-FURO = 683; CONTROL = 11 912): 968 died during index hospitalization [7.7%; FAST-FURO = 10.3% vs. CONTROL=7.5%; odds ratio (OR) = 1.403, 95% confidence interval (95% CI) = 1.085-1.813; P = 0.009], 1269 died during the first 30 days (10.2%; FAST-FURO = 13.4% vs. CONTROL = 9.9%; OR = 1.403, 95% CI = 1.146-1.764; P = 0.004), and 2844 had prolonged hospitalization (22.8%; FAST-FURO = 25.8% vs. CONTROL = 22.6%; OR = 1.189, 95% CI = 0.995-1.419; P = 0.056). FAST-FURO group patients had more diabetes mellitus, ischaemic cardiomyopathy, peripheral artery disease, left ventricular systolic dysfunction, and severe decompensations, and had a better New York Heart Association class and had less atrial fibrillation. After adjusting for these significant differences, early IV furosemide resulted in no impact on short-term outcomes: OR = 1.080 (95% CI = 0.817-1.427) for in-hospital mortality, OR = 1.086 (95% CI = 0.845-1.396) for 30-day mortality, and OR = 1.095 (95% CI = 0.915-1.312) for prolonged hospitalization. Several sensitivity analyses, including analysis of 599 pairs of patients matched by propensity score, showed consistent findings. Conclusion Early IV furosemide during the prehospital phase was administered to the sickest patients, was not associated with changes in short-term mortality or length of hospitalization after adjustment for several confounders.
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- 2021
31. Self-care of heart failure patients: practical management recommendations from the Heart Failure Association of the European Society of Cardiology
- Author
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Verplegingswetenschap, Circulatory Health, HAG Hart- Vaatziekten, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Jaarsma, T, Hill, L, Bayes-Genis, A, Brunner La Rocca, H P, Castiello, T, Čelutkienė, J, Marques-Sule, E, Plymen, C M, Piper, S E, Riegel, B, Rutten, F H, Ben Gal, T, Bauersachs, J, Coats, Ajs, Chioncel, O, Lopatin, Y, Lund, L H, Lainscak, M, Moura, B, Mullens, W, Piepoli, M F, Rosano, G, Seferovic, P, Strömberg, A, Verplegingswetenschap, Circulatory Health, HAG Hart- Vaatziekten, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Jaarsma, T, Hill, L, Bayes-Genis, A, Brunner La Rocca, H P, Castiello, T, Čelutkienė, J, Marques-Sule, E, Plymen, C M, Piper, S E, Riegel, B, Rutten, F H, Ben Gal, T, Bauersachs, J, Coats, Ajs, Chioncel, O, Lopatin, Y, Lund, L H, Lainscak, M, Moura, B, Mullens, W, Piepoli, M F, Rosano, G, Seferovic, P, and Strömberg, A
- Published
- 2021
32. Acute heart failure congestion and perfusion status – impact of the clinical classification on in-hospital and long-term outcomes; insights from the ESC-EORP-HFA Heart Failure Long-Term Registry
- Author
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Chioncel, O., Mebazaa, A., Maggioni, A. P., Harjola, V. -P., Rosano, G., Laroche, C., Piepoli, M. F., Crespo-Leiro, M. G., Lainscak, M., Ponikowski, P., Filippatos, G., Ruschitzka, F., Seferovic, P., Coats, A. J. S., Lund, L. H., Auer, J., Ablasser, K., Fruhwald, F., Dolze, T., Brandner, K., Gstrein, S., Poelzl, G., Moertl, D., Reiter, S., Podczeck-Schweighofer, A., Muslibegovic, A., Vasilj, M., Fazlibegovic, E., Cesko, M., Zelenika, D., Palic, B., Pravdic, D., Cuk, D., Vitlianova, K., Katova, T., Velikov, T., Kurteva, T., Gatzov, P., Kamenova, D., Antova, M., Sirakova, V., Krejci, J., Mikolaskova, M., Spinar, J., Krupicka, J., Malek, F., Hegarova, M., Lazarova, M., Monhart, Z., Hassanein, M., Sobhy, M., El Messiry, F., El Shazly, A. H., Elrakshy, Y., Youssef, A., Moneim, A. A., Noamany, M., Reda, A., Dayem, T. K. A., Farag, N., Halawa, S. I., Hamid, M. A., Said, K., Saleh, A., Ebeid, H., Hanna, R., Aziz, R., Louis, O., Enen, M. A., Ibrahim, B. S., Nasr, G., Elbahry, A., Sobhy, H., Ashmawy, M., Gouda, M., Aboleineen, W., Bernard, Y., Luporsi, P., Meneveau, N., Pillot, M., Morel, M., Seronde, M. -F., Schiele, F., Briand, F., Delahaye, F., Damy, T., Eicher, J. -C., de Groote, P., Fertin, M., Lamblin, N., Isnard, R., Lefol, C., Thevenin, S., Hagege, A., Jondeau, G., Logeart, D., Le Marcis, V., J. -F., Ly, Coisne, D., Lequeux, B., Le Moal, V., Mascle, S., Lotton, P., Behar, N., Donal, E., Thebault, C., Ridard, C., Reynaud, A., Basquin, A., Bauer, F., Codjia, R., Galinier, M., Tourikis, P., Stavroula, M., Tousoulis, D., Stefanadis, C., Chrysohoou, C., Kotrogiannis, I., Matzaraki, V., Dimitroula, T., Karavidas, A., Tsitsinakis, G., Kapelios, C., Nanas, J., Kampouri, H., Nana, E., Kaldara, E., Eugenidou, A., Vardas, P., Saloustros, I., Patrianakos, A., Tsaknakis, T., Evangelou, S., Nikoloulis, N., Tziourganou, H., Tsaroucha, A., Papadopoulou, A., Douras, A., Polgar, L., Merkely, B., Kosztin, A., Nyolczas, N., Nagy, A. C., Halmosi, R., Elber, J., Alony, I., Shotan, A., Fuhrmann, A. V., Amir, O., Romano, S., Marcon, S., Penco, M., Di Mauro, M., Lemme, E., Carubelli, V., Rovetta, R., Metra, M., Bulgari, M., Quinzani, F., Lombardi, C., Bosi, S., Schiavina, G., Squeri, A., Barbieri, A., Di Tano, G., Pirelli, S., Ferrari, R., Fucili, A., Passero, T., Musio, S., Di Biase, M., Correale, M., Salvemini, G., Brognoli, S., Zanelli, E., Giordano, A., Agostoni, P., Italiano, G., Salvioni, E., Copelli, S., Modena, M. G., Reggianini, L., Valenti, C., Olaru, A., Bandino, S., Deidda, M., Mercuro, G., Dessalvi, C. C., Marino, P. N., Di Ruocco, M. V., Sartori, C., Piccinino, C., Parrinello, G., Licata, G., Torres, D., Giambanco, S., Busalacchi, S., Arrotti, S., Novo, S., Inciardi, R. M., Pieri, P., Chirco, P. R., Galifi, M. A., Teresi, G., Buccheri, D., Minacapelli, A., Veniani, M., Frisinghelli, A., Priori, S. G., Cattaneo, S., Opasich, C., Gualco, A., Pagliaro, M., Mancone, M., Fedele, F., Cinque, A., Vellini, M., Scarfo, I., Romeo, F., Ferraiuolo, F., Sergi, D., Anselmi, M., Melandri, F., Leci, E., Iori, E., Bovolo, V., Pidello, S., Frea, S., Bergerone, S., Botta, M., Canavosio, F. G., Gaita, F., Merlo, M., Cinquetti, M., Sinagra, G., Ramani, F., Fabris, E., Stolfo, D., Artico, J., Miani, D., Fresco, C., Daneluzzi, C., Proclemer, A., Cicoira, M., Zanolla, L., Marchese, G., Torelli, F., Vassanelli, C., Voronina, N., Erglis, A., Tamakauskas, V., Smalinskas, V., Karaliute, R., Petraskiene, I., Kazakauskaite, E., Rumbinaite, E., Kavoliuniene, A., Vysniauskas, V., Brazyte-Ramanauskiene, R., Petraskiene, D., Stankala, S., Switala, P., Juszczyk, Z., Sinkiewicz, W., Gilewski, W., Pietrzak, J., Orzel, T., Kasztelowicz, P., Kardaszewicz, P., Lazorko-Piega, M., Gabryel, J., Mosakowska, K., Bellwon, J., Rynkiewicz, A., Raczak, G., Lewicka, E., Dabrowska-Kugacka, A., Bartkowiak, R., Sosnowska-Pasiarska, B., Wozakowska-Kaplon, B., Krzeminski, A., Zabojszcz, M., Mirek-Bryniarska, E., Grzegorzko, A., Bury, K., Nessler, J., Zalewski, J., Furman, A., Broncel, M., Poliwczak, A., Bala, A., Zycinski, P., Rudzinska, M., Jankowski, L., Kasprzak, J. D., Michalak, L., Soska, K. W., Drozdz, J., Huziuk, I., Retwinski, A., Flis, P., Weglarz, J., Bodys, A., Grajek, S., Kaluzna-Oleksy, M., Straburzynska-Migaj, E., Dankowski, R., Szymanowska, K., Grabia, J., Szyszka, A., Nowicka, A., Samcik, M., Wolniewicz, L., Baczynska, K., Komorowska, K., Poprawa, I., Komorowska, E., Sajnaga, D., Zolbach, A., Dudzik-Plocica, A., Abdulkarim, A. -F., Lauko-Rachocka, A., Kaminski, L., Kostka, A., Cichy, A., Ruszkowski, P., Splawski, M., Fitas, G., Szymczyk, A., Serwicka, A., Fiega, A., Zysko, D., Krysiak, W., Szabowski, S., Skorek, E., Pruszczyk, P., Bienias, P., Ciurzynski, M., Welnicki, M., Mamcarz, A., Folga, A., Zielinski, T., Rywik, T., Leszek, P., Sobieszczanska-Malek, M., Piotrowska, M., Kozar-Kaminska, K., Komuda, K., Wisniewska, J., Tarnowska, A., Balsam, P., Marchel, M., Opolski, G., Kaplon-Cieslicka, A., Gil, R. J., Mozenska, O., Byczkowska, K., Gil, K., Pawlak, A., Michalek, A., Krzesinski, P., Piotrowicz, K., Uzieblo-Zyczkowska, B., Stanczyk, A., Skrobowski, A., Jankowska, E., Rozentryt, P., Polonski, L., Gadula-Gacek, E., Nowalany-Kozielska, E., Kuczaj, A., Kalarus, Z., Szulik, M., Przybylska, K., Klys, J., Prokop-Lewicka, G., Kleinrok, A., Aguiar, C. T., Ventosa, A., Pereira, S., Faria, R., Chin, J., De Jesus, I., Santos, R., Silva, P., Moreno, N., Queiros, C., Lourenco, C., Pereira, A., Castro, A., Andrade, A., Guimaraes, T. O., Martins, S., Placido, R., Lima, G., Brito, D., Francisco, A. R., Cardiga, R., Proenca, M., Araujo, I., Marques, F., Fonseca, C., Moura, B., Leite, S., Campelo, M., Silva-Cardoso, J., Rodrigues, J., Rangel, I., Martins, E., Correia, A. S., Peres, M., Marta, L., da Silva, G. F., Severino, D., Durao, D., Leao, S., Magalhaes, P., Moreira, I., Cordeiro, A. F., Ferreira, C., Araujo, C., Ferreira, A., Baptista, A., Radoi, M., Bicescu, G., Vinereanu, D., Sinescu, C. -J., Macarie, C., Popescu, R., Daha, I., Dan, G. -A., Stanescu, C., Dan, A., Craiu, E., Nechita, E., Aursulesei, V., Christodorescu, R., Otasevic, P., Seferovic, P. M., Simeunovic, D., Ristic, A. D., Celic, V., Pavlovic-Kleut, M., Lazic, J. S., Stojcevski, B., Pencic, B., Stevanovic, A., Andric, A., Iric-Cupic, V., Jovic, M., Davidovic, G., Milanov, S., Mitic, V., Atanaskovic, V., Antic, S., Pavlovic, M., Stanojevic, D., Stoickov, V., Ilic, S., Ilic, M. D., Petrovic, D., Stojsic, S., Kecojevic, S., Dodic, S., Adic, N. C., Cankovic, M., Stojiljkovic, J., Mihajlovic, B., Radin, A., Radovanovic, S., Krotin, M., Klabnik, A., Goncalvesova, E., Pernicky, M., Murin, J., Kovar, F., Kmec, J., Semjanova, H., Strasek, M., Iskra, M. S., Ravnikar, T., Suligoj, N. C., Komel, J., Fras, Z., Jug, B., Glavic, T., Losic, R., Bombek, M., Krajnc, I., Krunic, B., Horvat, S., Kovac, D., Rajtman, D., Cencic, V., Letonja, M., Winkler, R., Valentincic, M., Melihen-Bartolic, C., Bartolic, A., Vrckovnik, M. P., Kladnik, M., Pusnik, C. S., Marolt, A., Klen, J., Drnovsek, B., Leskovar, B., Anguita, M. J. F., Page, J. C. G., Martinez, F. M. S., Andres, J., Genis, A. B., Mirabet, S., Mendez, A., Garcia-Cosio, L., Roig, E., Leon, V., Gonzalez-Costello, J., Muntane, G., Garay, A., Alcade-Martinez, V., Fernandez, S. L., Rivera-Lopez, R., Puga-Martinez, M., Fernandez-Alvarez, M., Serrano-Martinez, J. L., Crespo-Leiro, M., Grille-Cancela, Z., Marzoa-Rivas, R., Blanco-Canosa, P., Paniagua-Martin, M. J., Barge-Caballero, E., Cerdena, I. L., Baldomero, I. F. H., Padron, A. L., Rosillo, S. O., Gonzalez-Gallarza, R. D., Montanes, O. S., Manjavacas, A. M. I., Conde, A. C., Araujo, A., Soria, T., Garcia-Pavia, P., Gomez-Bueno, M., Cobo-Marcos, M., Alonso-Pulpon, L., Cubero, J. S., Sayago, I., Gonzalez-Segovia, A., Briceno, A., Subias, P. E., Hernandez, M. V., Cano, M. J. R., Sanchez, M. A. G., Jimenez, J. F. D., Garrido-Lestache, E. B., Pinilla, J. M. G., de la Villa, B. G., Sahuquillo, A., Marques, R. B., Calvo, F. T., Perez-Martinez, M. T., Gracia-Rodenas, M. R., Garrido-Bravo, I. P., Pastor-Perez, F., Pascual-Figal, D. A., Molina, B. D., Orus, J., Gonzalo, F. E., Bertomeu, V., Valero, R., Martinez-Abellan, R., Quiles, J., Rodrigez-Ortega, J. A., Mateo, I., Elamrani, A., Fernandez-Vivancos, C., Valero, D. B., Almenar-Bonet, L., Sanchez-Lazaro, I. J., Marques-Sule, E., Facila-Rubio, L., Perez-Silvestre, J., Garcia-Gonzalez, P., Ridocci-Soriano, F., Garcia-Escriva, D., Pellicer-Cabo, A., de la Fuente Galan, L., Diaz, J. L., Platero, A. R., Arias, J. C., Blasco-Peiro, T., Julve, M. S., Sanchez-Insa, E., Aured-Guallar, C., Portoles-Ocampo, A., Melin, M., Hagglund, E., Stenberg, A., Lindahl, I. -M., Asserlund, B., Olsson, L., Dahlstrom, U., Afzelius, M., Karlstrom, P., Tengvall, L., Wiklund, P. -A., Olsson, B., Kalayci, S., Temizhan, A., Cavusoglu, Y., Gencer, E., Yilmaz, M. B., Gunes, H., Chioncel, O., Mebazaa, A., Maggioni, A. P., Harjola, V. -P., Rosano, G., Laroche, C., Piepoli, M. F., Crespo-Leiro, M. G., Lainscak, M., Ponikowski, P., Filippatos, G., Ruschitzka, F., Seferovic, P., Coats, A. J. S., Lund, L. H., Auer, J., Ablasser, K., Fruhwald, F., Dolze, T., Brandner, K., Gstrein, S., Poelzl, G., Moertl, D., Reiter, S., Podczeck-Schweighofer, A., Muslibegovic, A., Vasilj, M., Fazlibegovic, E., Cesko, M., Zelenika, D., Palic, B., Pravdic, D., Cuk, D., Vitlianova, K., Katova, T., Velikov, T., Kurteva, T., Gatzov, P., Kamenova, D., Antova, M., Sirakova, V., Krejci, J., Mikolaskova, M., Spinar, J., Krupicka, J., Malek, F., Hegarova, M., Lazarova, M., Monhart, Z., Hassanein, M., Sobhy, M., El Messiry, F., El Shazly, A. H., Elrakshy, Y., Youssef, A., Moneim, A. A., Noamany, M., Reda, A., Dayem, T. K. A., Farag, N., Halawa, S. I., Hamid, M. A., Said, K., Saleh, A., Ebeid, H., Hanna, R., Aziz, R., Louis, O., Enen, M. A., Ibrahim, B. S., Nasr, G., Elbahry, A., Sobhy, H., Ashmawy, M., Gouda, M., Aboleineen, W., Bernard, Y., Luporsi, P., Meneveau, N., Pillot, M., Morel, M., Seronde, M. -F., Schiele, F., Briand, F., Delahaye, F., Damy, T., Eicher, J. -C., de Groote, P., Fertin, M., Lamblin, N., Isnard, R., Lefol, C., Thevenin, S., Hagege, A., Jondeau, G., Logeart, D., Le Marcis, V., Ly, J. -F., Coisne, D., Lequeux, B., Le Moal, V., Mascle, S., Lotton, P., Behar, N., Donal, E., Thebault, C., Ridard, C., Reynaud, A., Basquin, A., Bauer, F., Codjia, R., Galinier, M., Tourikis, P., Stavroula, M., Tousoulis, D., Stefanadis, C., Chrysohoou, C., Kotrogiannis, I., Matzaraki, V., Dimitroula, T., Karavidas, A., Tsitsinakis, G., Kapelios, C., Nanas, J., Kampouri, H., Nana, E., Kaldara, E., Eugenidou, A., Vardas, P., Saloustros, I., Patrianakos, A., Tsaknakis, T., Evangelou, S., Nikoloulis, N., Tziourganou, H., Tsaroucha, A., Papadopoulou, A., Douras, A., Polgar, L., Merkely, B., Kosztin, A., Nyolczas, N., Nagy, A. C., Halmosi, R., Elber, J., Alony, I., Shotan, A., Fuhrmann, A. V., Amir, O., Romano, S., Marcon, S., Penco, M., Di Mauro, M., Lemme, E., Carubelli, V., Rovetta, R., Metra, M., Bulgari, M., Quinzani, F., Lombardi, C., Bosi, S., Schiavina, G., Squeri, A., Barbieri, A., Di Tano, G., Pirelli, S., Ferrari, R., Fucili, A., Passero, T., Musio, S., Di Biase, M., Correale, M., Salvemini, G., Brognoli, S., Zanelli, E., Giordano, A., Agostoni, P., Italiano, G., Salvioni, E., Copelli, S., Modena, M. G., Reggianini, L., Valenti, C., Olaru, A., Bandino, S., Deidda, M., Mercuro, G., Dessalvi, C. C., Marino, P. N., Di Ruocco, M. V., Sartori, C., Piccinino, C., Parrinello, G., Licata, G., Torres, D., Giambanco, S., Busalacchi, S., Arrotti, S., Novo, S., Inciardi, R. M., Pieri, P., Chirco, P. R., Galifi, M. A., Teresi, G., Buccheri, D., Minacapelli, A., Veniani, M., Frisinghelli, A., Priori, S. G., Cattaneo, S., Opasich, C., Gualco, A., Pagliaro, M., Mancone, M., Fedele, F., Cinque, A., Vellini, M., Scarfo, I., Romeo, F., Ferraiuolo, F., Sergi, D., Anselmi, M., Melandri, F., Leci, E., Iori, E., Bovolo, V., Pidello, S., Frea, S., Bergerone, S., Botta, M., Canavosio, F. G., Gaita, F., Merlo, M., Cinquetti, M., Sinagra, G., Ramani, F., Fabris, E., Stolfo, D., Artico, J., Miani, D., Fresco, C., Daneluzzi, C., Proclemer, A., Cicoira, M., Zanolla, L., Marchese, G., Torelli, F., Vassanelli, C., Voronina, N., Erglis, A., Tamakauskas, V., Smalinskas, V., Karaliute, R., Petraskiene, I., Kazakauskaite, E., Rumbinaite, E., Kavoliuniene, A., Vysniauskas, V., Brazyte-Ramanauskiene, R., Petraskiene, D., Stankala, S., Switala, P., Juszczyk, Z., Sinkiewicz, W., Gilewski, W., Pietrzak, J., Orzel, T., Kasztelowicz, P., Kardaszewicz, P., Lazorko-Piega, M., Gabryel, J., Mosakowska, K., Bellwon, J., Rynkiewicz, A., Raczak, G., Lewicka, E., Dabrowska-Kugacka, A., Bartkowiak, R., Sosnowska-Pasiarska, B., Wozakowska-Kaplon, B., Krzeminski, A., Zabojszcz, M., Mirek-Bryniarska, E., Grzegorzko, A., Bury, K., Nessler, J., Zalewski, J., Furman, A., Broncel, M., Poliwczak, A., Bala, A., Zycinski, P., Rudzinska, M., Jankowski, L., Kasprzak, J. D., Michalak, L., Soska, K. W., Drozdz, J., Huziuk, I., Retwinski, A., Flis, P., Weglarz, J., Bodys, A., Grajek, S., Kaluzna-Oleksy, M., Straburzynska-Migaj, E., Dankowski, R., Szymanowska, K., Grabia, J., Szyszka, A., Nowicka, A., Samcik, M., Wolniewicz, L., Baczynska, K., Komorowska, K., Poprawa, I., Komorowska, E., Sajnaga, D., Zolbach, A., Dudzik-Plocica, A., Abdulkarim, A. -F., Lauko-Rachocka, A., Kaminski, L., Kostka, A., Cichy, A., Ruszkowski, P., Splawski, M., Fitas, G., Szymczyk, A., Serwicka, A., Fiega, A., Zysko, D., Krysiak, W., Szabowski, S., Skorek, E., Pruszczyk, P., Bienias, P., Ciurzynski, M., Welnicki, M., Mamcarz, A., Folga, A., Zielinski, T., Rywik, T., Leszek, P., Sobieszczanska-Malek, M., Piotrowska, M., Kozar-Kaminska, K., Komuda, K., Wisniewska, J., Tarnowska, A., Balsam, P., Marchel, M., Opolski, G., Kaplon-Cieslicka, A., Gil, R. J., Mozenska, O., Byczkowska, K., Gil, K., Pawlak, A., Michalek, A., Krzesinski, P., Piotrowicz, K., Uzieblo-Zyczkowska, B., Stanczyk, A., Skrobowski, A., Jankowska, E., Rozentryt, P., Polonski, L., Gadula-Gacek, E., Nowalany-Kozielska, E., Kuczaj, A., Kalarus, Z., Szulik, M., Przybylska, K., Klys, J., Prokop-Lewicka, G., Kleinrok, A., Aguiar, C. T., Ventosa, A., Pereira, S., Faria, R., Chin, J., De Jesus, I., Santos, R., Silva, P., Moreno, N., Queiros, C., Lourenco, C., Pereira, A., Castro, A., Andrade, A., Guimaraes, T. O., Martins, S., Placido, R., Lima, G., Brito, D., Francisco, A. R., Cardiga, R., Proenca, M., Araujo, I., Marques, F., Fonseca, C., Moura, B., Leite, S., Campelo, M., Silva-Cardoso, J., Rodrigues, J., Rangel, I., Martins, E., Correia, A. S., Peres, M., Marta, L., da Silva, G. F., Severino, D., Durao, D., Leao, S., Magalhaes, P., Moreira, I., Cordeiro, A. F., Ferreira, C., Araujo, C., Ferreira, A., Baptista, A., Radoi, M., Bicescu, G., Vinereanu, D., Sinescu, C. -J., Macarie, C., Popescu, R., Daha, I., Dan, G. -A., Stanescu, C., Dan, A., Craiu, E., Nechita, E., Aursulesei, V., Christodorescu, R., Otasevic, P., Seferovic, P. M., Simeunovic, D., Ristic, A. D., Celic, V., Pavlovic-Kleut, M., Lazic, J. S., Stojcevski, B., Pencic, B., Stevanovic, A., Andric, A., Iric-Cupic, V., Jovic, M., Davidovic, G., Milanov, S., Mitic, V., Atanaskovic, V., Antic, S., Pavlovic, M., Stanojevic, D., Stoickov, V., Ilic, S., Ilic, M. D., Petrovic, D., Stojsic, S., Kecojevic, S., Dodic, S., Adic, N. C., Cankovic, M., Stojiljkovic, J., Mihajlovic, B., Radin, A., Radovanovic, S., Krotin, M., Klabnik, A., Goncalvesova, E., Pernicky, M., Murin, J., Kovar, F., Kmec, J., Semjanova, H., Strasek, M., Iskra, M. S., Ravnikar, T., Suligoj, N. C., Komel, J., Fras, Z., Jug, B., Glavic, T., Losic, R., Bombek, M., Krajnc, I., Krunic, B., Horvat, S., Kovac, D., Rajtman, D., Cencic, V., Letonja, M., Winkler, R., Valentincic, M., Melihen-Bartolic, C., Bartolic, A., Vrckovnik, M. P., Kladnik, M., Pusnik, C. S., Marolt, A., Klen, J., Drnovsek, B., Leskovar, B., Anguita, M. J. F., Page, J. C. G., Martinez, F. M. S., Andres, J., Bayes-Genis, A., Mirabet, S., Mendez, A., Garcia-Cosio, L., Roig, E., Leon, V., Gonzalez-Costello, J., Muntane, G., Garay, A., Alcade-Martinez, V., Fernandez, S. L., Rivera-Lopez, R., Puga-Martinez, M., Fernandez-Alvarez, M., Serrano-Martinez, J. L., Crespo-Leiro, M., Grille-Cancela, Z., Marzoa-Rivas, R., Blanco-Canosa, P., Paniagua-Martin, M. J., Barge-Caballero, E., Cerdena, I. L., Baldomero, I. F. H., Padron, A. L., Rosillo, S. O., Gonzalez-Gallarza, R. D., Montanes, O. S., Manjavacas, A. M. I., Conde, A. C., Araujo, A., Soria, T., Garcia-Pavia, P., Gomez-Bueno, M., Cobo-Marcos, M., Alonso-Pulpon, L., Cubero, J. S., Sayago, I., Gonzalez-Segovia, A., Briceno, A., Subias, P. E., Hernandez, M. V., Cano, M. J. R., Sanchez, M. A. G., Jimenez, J. F. D., Garrido-Lestache, E. B., Pinilla, J. M. G., de la Villa, B. G., Sahuquillo, A., Marques, R. B., Calvo, F. T., Perez-Martinez, M. T., Gracia-Rodenas, M. R., Garrido-Bravo, I. P., Pastor-Perez, F., Pascual-Figal, D. A., Molina, B. D., Orus, J., Gonzalo, F. E., Bertomeu, V., Valero, R., Martinez-Abellan, R., Quiles, J., Rodrigez-Ortega, J. A., Mateo, I., Elamrani, A., Fernandez-Vivancos, C., Valero, D. B., Almenar-Bonet, L., Sanchez-Lazaro, I. J., Marques-Sule, E., Facila-Rubio, L., Perez-Silvestre, J., Garcia-Gonzalez, P., Ridocci-Soriano, F., Garcia-Escriva, D., Pellicer-Cabo, A., de la Fuente Galan, L., Diaz, J. L., Platero, A. R., Arias, J. C., Blasco-Peiro, T., Julve, M. S., Sanchez-Insa, E., Aured-Guallar, C., Portoles-Ocampo, A., Melin, M., Hagglund, E., Stenberg, A., Lindahl, I. -M., Asserlund, B., Olsson, L., Dahlstrom, U., Afzelius, M., Karlstrom, P., Tengvall, L., Wiklund, P. -A., Olsson, B., Kalayci, S., Temizhan, A., Cavusoglu, Y., Gencer, E., Yilmaz, M. B., and Gunes, H.
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Adult ,Male ,Registry ,medicine.medical_specialty ,New York Heart Association Class ,Acute heart failure ,Congestion ,Forrester classification ,Outcomes ,Perfusion ,Acute Disease ,Aged ,Blood Pressure ,Coronary Circulation ,Female ,Follow-Up Studies ,Heart Failure ,Hospital Mortality ,Humans ,Long-Term Care ,Middle Aged ,Registries ,Risk Factors ,Treatment Outcome ,Hospitalization ,030204 cardiovascular system & hematology ,Lower risk ,03 medical and health sciences ,0302 clinical medicine ,Diabetes mellitus ,Long term outcomes ,Medicine ,Outcome ,business.industry ,Hazard ratio ,acute heart failure ,congestion ,forrester classification ,outcomes ,perfusion ,registry ,acute disease ,adult ,aged ,blood pressure ,coronary circulation ,female ,follow-up studies ,heart failure ,hospital mortality ,humans ,long-term care ,male ,middle aged ,registries ,risk factors ,treatment outcome ,hospitalization ,medicine.disease ,Confidence interval ,3. Good health ,Heart failure ,Emergency medicine ,Cardiology and Cardiovascular Medicine ,business - Abstract
[Abstract] Aims: Classification of acute heart failure (AHF) patients into four clinical profiles defined by evidence of congestion and perfusion is advocated by the 2016 European Society of Cardiology (ESC)guidelines. Based on the ESC-EORP-HFA Heart Failure Long-Term Registry, we compared differences in baseline characteristics, in-hospital management and outcomes among congestion/perfusion profiles using this classification. Methods and results: We included 7865 AHF patients classified at admission as: 'dry-warm' (9.9%), 'wet-warm' (69.9%), 'wet-cold' (19.8%) and 'dry-cold' (0.4%). These groups differed significantly in terms of baseline characteristics, in-hospital management and outcomes. In-hospital mortality was 2.0% in 'dry-warm', 3.8% in 'wet-warm', 9.1% in 'dry-cold' and 12.1% in 'wet-cold' patients. Based on clinical classification at admission, the adjusted hazard ratios (95% confidence interval) for 1-year mortality were: 'wet-warm' vs. 'dry-warm' 1.78 (1.43-2.21) and 'wet-cold' vs. 'wet-warm' 1.33 (1.19-1.48). For profiles resulting from discharge classification, the adjusted hazard ratios (95% confidence interval) for 1-year mortality were: 'wet-warm' vs. 'dry-warm' 1.46 (1.31-1.63) and 'wet-cold' vs. 'wet-warm' 2.20 (1.89-2.56). Among patients discharged alive, 30.9% had residual congestion, and these patients had higher 1-year mortality compared to patients discharged without congestion (28.0 vs. 18.5%). Tricuspid regurgitation, diabetes, anaemia and high New York Heart Association class were independently associated with higher risk of congestion at discharge, while beta-blockers at admission, de novo heart failure, or any cardiovascular procedure during hospitalization were associated with lower risk of residual congestion. Conclusion: Classification based on congestion/perfusion status provides clinically relevant information at hospital admission and discharge. A better understanding of the clinical course of the two entities could play an important role towards the implementation of targeted strategies that may improve outcomes.
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- 2019
33. Lessons learned in acute heart failure
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Cheema, B, Ambrosy, A, Kaplan, R, Senni, M, Fonarow, G, Chioncel, O, Butler, J, Gheorghiade, M, Cheema B, Ambrosy AP, Kaplan RM, Senni M, Fonarow GC, Chioncel O, Butler J, Gheorghiade M., Cheema, B, Ambrosy, A, Kaplan, R, Senni, M, Fonarow, G, Chioncel, O, Butler, J, Gheorghiade, M, Cheema B, Ambrosy AP, Kaplan RM, Senni M, Fonarow GC, Chioncel O, Butler J, and Gheorghiade M.
- Abstract
Acute heart failure (HF) is a global pandemic with more than one million admissions to hospital annually in the US and millions more worldwide. Post-discharge mortality and readmission rates remain unchanged and unacceptably high. Although recent drug development programmes have failed to deliver novel therapies capable of reducing cardiovascular morbidity and mortality in patients hospitalized for worsening chronic HF, hospitalized HF registries and clinical trial databases have generated a wealth of information improving our collective understanding of the HF syndrome. This review will summarize key insights from clinical trials in acute HF and hospitalized HF registries over the last several decades, focusing on improving the management of patients with HF and reduced ejection fraction.
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- 2018
34. Sodium–glucose co‐transporter 2 inhibitors in heart failure: beyond glycaemic control. The position paper of the Heart Failure Association of the European Society of Cardiology
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Seferović, PM, Fragasso, G, Petrie, M, Mullens, W, Ferrari, R, Thum, T, Bauersachs, J, Anker, SD, Ray, R, Çavuşoğlu, Y, Polovina, M, Metra, M, Ambrosio, G, Prasad, K, Seferović, J, Jhund, PS, Dattilo, G, Čelutkiene, J, Piepoli, M, Moura, B, Chioncel, O, Gal, TB, Heymans, S, De Boer, RA, Jaarsma, T, Hill, L, Lopatin, Y, Lyon, AR, Ponikowski, P, Lainščak, M, Jankowska, E, Mueller, C, Cosentino, F, Lund, L, Filippatos, GS, Ruschitzka, F, Coats, AJS, and Rosano, GMC
- Abstract
Heart failure (HF) is common and associated with a poor prognosis, despite advances in treatment. Over the last decade cardiovascular outcome trials with sodium–glucose co‐transporter 2 (SGLT2) inhibitors in patients with type 2 diabetes mellitus have demonstrated beneficial effects for three SGLT2 inhibitors (empagliflozin, canagliflozin and dapagliflozin) in reducing hospitalisations for HF. More recently, dapagliflozin reduced the risk of worsening HF or death from cardiovascular causes in patients with chronic HF with reduced left ventricular ejection fraction, with or without type 2 diabetes mellitus. A number of additional trials in HF patients with reduced and/or preserved left ventricular ejection fraction are ongoing and/or about to be reported. The present position paper summarises recent clinical trial evidence and discusses the role of SGLT2 inhibitors in the treatment of HF, pending the results of ongoing trials in different populations of patients with HF.
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- 2020
35. Role of cardiovascular imaging in cancer patients receiving cardiotoxic therapies
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Celutkiene, J., Pudil, R., Lopez-Fernandez, T., Grapsa, J., Nihoyannopoulos, P., Bergler-Klein, J., Cohen-Solal, A., Farmakis, D., Tocchetti, C. G., Haehling, S., Barberis, V., Flachskampf, F. A., Ceponlene, J., Haegler-Laube, E., Suter, T., Lapinskas, T., Prasad, S., Boer, R. A., Wechalekar, K., Anker, M. S., Iakobishvili, Z., Bucciarelli-Ducci, C., Schulz-Menger, J., Cosyns, B., Gaemperli, O., Belenkov, Y., Hulot, J-S, Galderisi, M., Lancellotti, P., Bax, J., Marwick, T. H., Chioncel, O., Jaarsma, T., Mullens, W., Piepoli, M., Thum, T., Heymans, S., Mueller, C., Moura, B., Ruschitzka, F., Zamorano, J. L., Rosano, G., Coats, A. J. S., Asteggiano, R., Seferovic, P., Thor Edvardsen, Lyon, A. R., Cardiovascular Centre (CVC), Hulot, Jean-Sebastien/0000-0001-5463-6117, Edvardsen, Thor/0000-0002-3800-765X, Bucciarelli-Ducci, Chiara/0000-0002-2515-0852, Clinical sciences, Cardio-vascular diseases, Cardiology, Cardiologie, MUMC+: MA Med Staf Spec Cardiologie (9), and RS: Carim - H02 Cardiomyopathy
- Subjects
Vascular Endothelial Growth Factor A ,Global longitudinal strain ,SPECKLE-TRACKING ECHOCARDIOGRAPHY ,Cardiac magnetic resonance ,Cardiology ,Antineoplastic Agents ,Heart failure ,ANTHRACYCLINE CARDIOTOXICITY ,Imaging ,LEFT-VENTRICULAR FUNCTION ,Neoplasms ,MAGNETIC-RESONANCE ,BREAST-CANCER ,Humans ,AMERICAN SOCIETY ,Computed tomography ,Cardiotoxicity ,MYOCARDIAL STRAIN ,DIASTOLIC FUNCTION ,Cardio-oncology ,Radiology Nuclear Medicine and imaging ,Echocardiography ,oncology ,Female ,CHAMBER QUANTIFICATION ,Cardiology and Cardiovascular Medicine ,Nuclear imaging - Abstract
Cardiovascular (CV) imaging is an important tool in baseline risk assessment and detection of CV disease in oncology patients receiving cardiotoxic cancer therapies. This position statement examines the role of echocardiography, cardiac magnetic resonance, nuclear cardiac imaging and computed tomography in the management of cancer patients. The Imaging and Cardio-Oncology Study Groups of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) in collaboration with the European Association of Cardiovascular Imaging (EACVI) and the Cardio-Oncology Council of the ESC have evaluated the current evidence for the value of modern CV imaging in the cardio-oncology field. The most relevant echocardiographic parameters, including global longitudinal strain and three-dimensional ejection fraction, are proposed. The protocol for baseline pre-treatment evaluation and specific surveillance algorithms or pathways for anthracycline chemotherapy, HER2-targeted therapies such as trastuzumab, vascular endothelial growth factor tyrosine kinase inhibitors, BCr-Abl tyrosine kinase inhibitors, proteasome inhibitors and immune checkpoint inhibitors are presented. The indications for CV imaging after completion of oncology treatment are considered. The typical consequences of radiation therapy and the possibility of their identification in the long term are also summarized. Special populations are discussed including female survivors planning pregnancy, patients with carcinoid disease, patients with cardiac tumours and patients with right heart failure. Future directions and ongoing CV imaging research in cardio-oncology are discussed. R.A.d.B. is supported by the Netherlands Heart Foundation (CVON DOSIS, grant 2014-40, CVON SHE-PREDICTS-HF, grant 2017-21, and CVON RED-CVD, grant 2017-11), and the European Research Council (ERC CoG 818715, SECRETE-HF). C.G.T. is supported by a Federico II University/Ricerca di Ateneo grant. Celutkiene, J (corresponding author), Vilnius Univ, Fac Med, Inst Clin Med, Clin Cardiac & Vasc Dis, Santariskiu 2, LT-08661 Vilnius, Lithuania. jelena.celutkiene@santa.lt
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- 2020
36. 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD
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Cosentino, F., Grant, P. J., Aboyans, V., Bailey, C. J., Ceriello, A., Delgado, V., Federici, M., Filippatos, G., Grobbee, D. E., Hansen, T. B., Huikuri, H. V., Johansson, I., Juni, P., Lettino, M., Marx, N., Mellbin, L. G., Ostgren, C. J., Rocca, Bianca, Roffi, M., Sattar, N., Seferovic, P. M., Sousa-Uva, M., Valensi, P., Wheeler, D. C., Piepoli, M. F., Birkeland, K. I., Adamopoulos, S., Ajjan, R., Avogaro, A., Baigent, C., Brodmann, M., Bueno, H., Ceconi, C., Chioncel, O., Coats, A., Collet, J. -P., Collins, P., Cosyns, B., Di Mario, C., Fisher, M., Fitzsimons, D., Halvorsen, S., Hansen, D., Hoes, A., Holt, R. I. G., Home, P., Katus, H. A., Khunti, K., Komajda, M., Lambrinou, E., Landmesser, U., Lewis, B. S., Linde, C., Lorusso, R., Mach, F., Mueller, C., Neumann, F. -J., Persson, F., Petersen, S. E., Petronio, A. S., Richter, D. J., Rosano, G. M. C., Rossing, P., Ryden, L., Shlyakhto, E., Simpson, I. A., Touyz, R. M., Wijns, W., Wilhelm, M., Williams, B., Windecker, S., Dean, V., Gale, C. P., Hindricks, G., Iung, B., Leclercq, C., Merkely, B., Zelveian, P. H., Scherr, D., Jahangirov, T., Lazareva, I., Shivalkar, B., Naser, N., Gruev, I., Milicic, D., Petrou, P. M., Linhart, A., Hildebrandt, P., Hasan-Ali, H., Marandi, T., Lehto, S., Mansourati, J., Kurashvili, R., Siasos, G., Lengyel, C., Thrainsdottir, I. S., Aronson, D., Di Lenarda, A., Raissova, A., Ibrahimi, P., Abilova, S., Trusinskis, K., Saade, G., Benlamin, H., Petrulioniene, Z., Banu, C., Magri, C. J., David, L., Boskovic, A., Alami, M., Liem, A. H., Bosevski, M., Svingen, G. F. T., Janion, M., Gavina, C., Vinereanu, D., Nedogoda, S., Mancini, T., Ilic, M. D., Fabryova, L., Fras, Z., Jimenez-Navarro, M. F., Norhammar, A., Lehmann, R., Mourali, M. S., Ural, D., Nesukay, E., Chowdhury, T. A., Clinical sciences, Cardio-vascular diseases, Cardiology, Human Physiology and Special Physiology of Physical Education, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), University of Zurich, and Cosentino, Francesco
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Settore MED/09 - Medicina Interna ,Epidemiology ,[SDV]Life Sciences [q-bio] ,10265 Clinic for Endocrinology and Diabetology ,Psychological intervention ,Disease ,Impaired glucose tolerance ,Diabetes mellitus ,Health care ,risk factors ,Guidelines ,cardiovascular diseases ,cardiovascular risk assessment ,diabetes mellitus ,epidemiology ,impaired glucose tolerance ,patient management ,patient-centred care ,pharmacological treatment ,prevention ,revascularization ,Prediabetes ,ComputingMilieux_MISCELLANEOUS ,Societies, Medical ,ddc:616 ,Cardiovascular risk assessment ,3. Good health ,Europe ,Cardiovascular diseases ,Pre diabetes ,Practice Guidelines as Topic ,Cardiology and Cardiovascular Medicine ,Pharmacological treatment ,medicine.medical_specialty ,Patient management ,Patient-centred care ,Prevention ,Revascularization ,Risk factors ,Settore BIO/14 - FARMACOLOGIA ,Cardiology ,610 Medicine & health ,2705 Cardiology and Cardiovascular Medicine ,Prediabetic State ,medicine ,Humans ,business.industry ,medicine.disease ,Diabetes Mellitus, Type 2 ,Family medicine ,business - Abstract
This is the second iteration of the European Society of Cardiology (ESC) and European Association for the Study of Diabetes (EASD) joining forces to write guidelines on the management of diabetes mellitus (DM), pre-diabetes, and cardiovascular disease (CVD), designed to assist clinicians and other healthcare workers to make evidence-based management decisions. The growing awareness of the strong biological relationship between DM and CVD rightly prompted these two large organizations to collaborate to generate guidelines relevant to their joint interests, the first of which were published in 2007. Some assert that too many guidelines are being produced but, in this burgeoning field, five years in the development of both basic and clinical science is a long time and major trials have reported in this period, making it necessary to update the previous Guidelines.
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- 2020
37. Departments involved during the first episode of acute heart failure and analysis of emergency department revisits and rehospitalisations: an outlook through the NOVICA cohort (vol 21, pg 1231, 2019)
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Miro O, Sarasola A, Fuenzalida C, Calderon S, Jacob J, Aguirre A, Wu D, Rizzi M, Malchair P, Haro A, Herrera S, Gil V, Martin-Sanchez F, Llorens P, Puente P, Bueno H, Rodriguez A, Muller C, Mebazaa A, Chioncel O, Alquezar-Arbe A, and ICA-SEMES Res Grp
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- 2020
38. Common mechanistic pathways in cancer and heart failure. A scientific roadmap on behalf of the Translational Research Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC)
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de Boer, R.A. Hulot, J.-S. Tocchetti, C.G. Aboumsallem, J.P. Ameri, P. Anker, S.D. Bauersachs, J. Bertero, E. Coats, A.J.S. Čelutkienė, J. Chioncel, O. Dodion, P. Eschenhagen, T. Farmakis, D. Bayes-Genis, A. Jäger, D. Jankowska, E.A. Kitsis, R.N. Konety, S.H. Larkin, J. Lehmann, L. Lenihan, D.J. Maack, C. Moslehi, J.J. Müller, O.J. Nowak-Sliwinska, P. Piepoli, M.F. Ponikowski, P. Pudil, R. Rainer, P.P. Ruschitzka, F. Sawyer, D. Seferovic, P.M. Suter, T. Thum, T. van der Meer, P. Van Laake, L.W. von Haehling, S. Heymans, S. Lyon, A.R. Backs, J.
- Abstract
The co-occurrence of cancer and heart failure (HF) represents a significant clinical drawback as each disease interferes with the treatment of the other. In addition to shared risk factors, a growing body of experimental and clinical evidence reveals numerous commonalities in the biology underlying both pathologies. Inflammation emerges as a common hallmark for both diseases as it contributes to the initiation and progression of both HF and cancer. Under stress, malignant and cardiac cells change their metabolic preferences to survive, which makes these metabolic derangements a great basis to develop intersection strategies and therapies to combat both diseases. Furthermore, genetic predisposition and clonal haematopoiesis are common drivers for both conditions and they hold great clinical relevance in the context of personalized medicine. Additionally, altered angiogenesis is a common hallmark for failing hearts and tumours and represents a promising substrate to target in both diseases. Cardiac cells and malignant cells interact with their surrounding environment called stroma. This interaction mediates the progression of the two pathologies and understanding the structure and function of each stromal component may pave the way for innovative therapeutic strategies and improved outcomes in patients. The interdisciplinary collaboration between cardiologists and oncologists is essential to establish unified guidelines. To this aim, pre-clinical models that mimic the human situation, where both pathologies coexist, are needed to understand all the aspects of the bidirectional relationship between cancer and HF. Finally, adequately powered clinical studies, including patients from all ages, and men and women, with proper adjudication of both cancer and cardiovascular endpoints, are essential to accurately study these two pathologies at the same time. © 2020 The Authors. European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.
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- 2020
39. Heart Failure Association of the European Society of Cardiology update on sodium–glucose co-transporter 2 inhibitors in heart failure (an update on the sodium–glucose co-transporter 2 inhibitors in heart failure: beyond glycaemic control. A position paper of the Heart Failure Association of the European Society of Cardiology)
- Author
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Seferovic, P. M., Fragasso, G., Petrie, M., Mullens, W., Ferrari, R., Thum, T., Bauersachs, J., Anker, S. D., Ray, R., Cavusoglu, Y., Polovina, M., Metra, M., Ambrosio, G., Prasad, K., Seferovic, J., Jhund, P. S., Dattilo, G., Celutkiene, J., Piepoli, M., Moura, B., Chioncel, O., Ben Gal, T., Heymans, S., Jaarsma, T., Hill, L., Lopatin, Y., Lyon, A. R., Ponikowski, P., Lainscak, M., Jankowska, E., Mueller, C., Cosentino, F., Lund, L. H., Filippatos, G. S., Ruschitzka, F., Coats, A. J. S., and Rosano, G. M. C.
- Subjects
Cardiovascular outcomes ,Type 2 diabetes mellitus ,Heart failure ,Sodium–glucose co-transporter 2 inhibitors ,Renal function - Published
- 2020
40. Role of serum biomarkers in cancer patients receiving cardiotoxic cancer therapies: a position statement from the Cardio-Oncology Study Group of the Heart Failure Association and the Cardio-Oncology Council of the European Society of Cardiology
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Pudil, R. Mueller, C. Čelutkienė, J. Henriksen, P.A. Lenihan, D. Dent, S. Barac, A. Stanway, S. Moslehi, J. Suter, T.M. Ky, B. Štěrba, M. Cardinale, D. Cohen-Solal, A. Tocchetti, C.G. Farmakis, D. Bergler-Klein, J. Anker, M.S. Von Haehling, S. Belenkov, Y. Iakobishvili, Z. Maack, C. Ciardiello, F. Ruschitzka, F. Coats, A.J.S. Seferovic, P. Lainscak, M. Piepoli, M.F. Chioncel, O. Bax, J. Hulot, J.-S. Skouri, H. Hägler-Laube, E.S. Asteggiano, R. Fernandez, T.L. de Boer, R.A. Lyon, A.R.
- Abstract
Serum biomarkers are an important tool in the baseline risk assessment and diagnosis of cardiovascular disease in cancer patients receiving cardiotoxic cancer treatments. Increases in cardiac biomarkers including cardiac troponin and natriuretic peptides can be used to guide initiation of cardioprotective treatments for cancer patients during treatment and to monitor the response to cardioprotective treatments, and they also offer prognostic value. This position statement examines the role of cardiac biomarkers in the management of cancer patients. The Cardio-Oncology Study Group of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) in collaboration with the Cardio-Oncology Council of the ESC have evaluated the current evidence for the role of cardiovascular biomarkers in cancer patients before, during and after cardiotoxic cancer therapies. The characteristics of the main two biomarkers troponin and natriuretic peptides are discussed, the link to the mechanisms of cardiovascular toxicity, and the evidence for their clinical use in surveillance during and after anthracycline chemotherapy, trastuzumab and HER2-targeted therapies, vascular endothelial growth factor inhibitors, proteasome inhibitors, immune checkpoint inhibitors, cyclophosphamide and radiotherapy. Novel surveillance clinical pathways integrating cardiac biomarkers for cancer patients receiving anthracycline chemotherapy or trastuzumab biomarkers are presented and future direction in cardio-oncology biomarker research is discussed. © 2020 European Society of Cardiology
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- 2020
41. Heart Failure Association of the European Society of Cardiology update on sodium–glucose co-transporter 2 inhibitors in heart failure
- Author
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Seferović, P.M. Fragasso, G. Petrie, M. Mullens, W. Ferrari, R. Thum, T. Bauersachs, J. Anker, S.D. Ray, R. Çavuşoğlu, Y. Polovina, M. Metra, M. Ambrosio, G. Prasad, K. Seferović, J. Jhund, P.S. Dattilo, G. Čelutkiene, J. Piepoli, M. Moura, B. Chioncel, O. Ben Gal, T. Heymans, S. Jaarsma, T. Hill, L. Lopatin, Y. Lyon, A.R. Ponikowski, P. Lainščak, M. Jankowska, E. Mueller, C. Cosentino, F. Lund, L.H. Filippatos, G.S. Ruschitzka, F. Coats, A.J.S. Rosano, G.M.C.
- Abstract
The Heart Failure Association (HFA) of the European Society of Cardiology (ESC) has recently issued a position paper on the role of sodium–glucose co-transporter 2 (SGLT2) inhibitors in heart failure (HF). The present document provides an update of the position paper, based of new clinical trial evidence. Accordingly, the following recommendations are given:. • Canagliflozin, dapagliflozin empagliflozin, or ertugliflozin are recommended for the prevention of HF hospitalization in patients with type 2 diabetes mellitus and established cardiovascular disease or at high cardiovascular risk. • Dapagliflozin or empagliflozin are recommended to reduce the combined risk of HF hospitalization and cardiovascular death in symptomatic patients with HF and reduced ejection fraction already receiving guideline-directed medical therapy regardless of the presence of type 2 diabetes mellitus. © 2020 European Society of Cardiology
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- 2020
42. Baseline cardiovascular risk assessment in cancer patients scheduled to receive cardiotoxic cancer therapies: a position statement and new risk assessment tools from the Cardio-Oncology Study Group of the Heart Failure Association of the European Society of Cardiology in collaboration with the International Cardio-Oncology Society
- Author
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Lyon, A.R. Dent, S. Stanway, S. Earl, H. Brezden-Masley, C. Cohen-Solal, A. Tocchetti, C.G. Moslehi, J.J. Groarke, J.D. Bergler-Klein, J. Khoo, V. Tan, L.L. Anker, M.S. von Haehling, S. Maack, C. Pudil, R. Barac, A. Thavendiranathan, P. Ky, B. Neilan, T.G. Belenkov, Y. Rosen, S.D. Iakobishvili, Z. Sverdlov, A.L. Hajjar, L.A. Macedo, A.V.S. Manisty, C. Ciardiello, F. Farmakis, D. de Boer, R.A. Skouri, H. Suter, T.M. Cardinale, D. Witteles, R.M. Fradley, M.G. Herrmann, J. Cornell, R.F. Wechelaker, A. Mauro, M.J. Milojkovic, D. de Lavallade, H. Ruschitzka, F. Coats, A.J.S. Seferovic, P.M. Chioncel, O. Thum, T. Bauersachs, J. Andres, M.S. Wright, D.J. López-Fernández, T. Plummer, C. Lenihan, D.
- Abstract
This position statement from the Heart Failure Association of the European Society of Cardiology Cardio-Oncology Study Group in collaboration with the International Cardio-Oncology Society presents practical, easy-to-use and evidence-based risk stratification tools for oncologists, haemato-oncologists and cardiologists to use in their clinical practice to risk stratify oncology patients prior to receiving cancer therapies known to cause heart failure or other serious cardiovascular toxicities. Baseline risk stratification proformas are presented for oncology patients prior to receiving the following cancer therapies: anthracycline chemotherapy, HER2-targeted therapies such as trastuzumab, vascular endothelial growth factor inhibitors, second and third generation multi-targeted kinase inhibitors for chronic myeloid leukaemia targeting BCR-ABL, multiple myeloma therapies (proteasome inhibitors and immunomodulatory drugs), RAF and MEK inhibitors or androgen deprivation therapies. Applying these risk stratification proformas will allow clinicians to stratify cancer patients into low, medium, high and very high risk of cardiovascular complications prior to starting treatment, with the aim of improving personalised approaches to minimise the risk of cardiovascular toxicity from cancer therapies. © 2020 The Authors. European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.
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- 2020
43. European Society of Cardiology/Heart Failure Association position paper on the role and safety of new glucose-lowering drugs in patients with heart failure
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Seferović, P.M. Coats, A.J.S. Ponikowski, P. Filippatos, G. Huelsmann, M. Jhund, P.S. Polovina, M.M. Komajda, M. Seferović, J. Sari, I. Cosentino, F. Ambrosio, G. Metra, M. Piepoli, M. Chioncel, O. Lund, L.H. Thum, T. De Boer, R.A. Mullens, W. Lopatin, Y. Volterrani, M. Hill, L. Bauersachs, J. Lyon, A. Petrie, M.C. Anker, S. Rosano, G.M.C.
- Abstract
Type 2 diabetes mellitus (T2DM) is common in patients with heart failure (HF) and associated with considerable morbidity and mortality. Significant advances have recently occurred in the treatment of T2DM, with evidence of several new glucose-lowering medications showing either neutral or beneficial cardiovascular effects. However, some of these agents have safety characteristics with strong practical implications in HF [i.e. dipeptidyl peptidase-4 (DPP-4) inhibitors, glucagon-like peptide-1 receptor agonists (GLP-1 RA), and sodium–glucose co-transporter type 2 (SGLT-2) inhibitors]. Regarding safety of DPP-4 inhibitors, saxagliptin is not recommended in HF because of a greater risk of HF hospitalisation. There is no compelling evidence of excess HF risk with the other DPP-4 inhibitors. GLP-1 RAs have an overall neutral effect on HF outcomes. However, a signal of harm suggested in two small trials of liraglutide in patients with reduced ejection fraction indicates that their role remains to be defined in established HF. SGLT-2 inhibitors (empagliflozin, canagliflozin and dapagliflozin) have shown a consistent reduction in the risk of HF hospitalisation regardless of baseline cardiovascular risk or history of HF. Accordingly, SGLT-2 inhibitors could be recommended to prevent HF hospitalisation in patients with T2DM and established cardiovascular disease or with multiple risk factors. The recently completed trial with dapagliflozin has shown a significant reduction in cardiovascular mortality and HF events in patients with HF and reduced ejection fraction, with or without T2DM. Several ongoing trials will assess whether the results observed with dapagliflozin could be extended to other SGLT-2 inhibitors in the treatment of HF, with either preserved or reduced ejection fraction, regardless of the presence of T2DM. This position paper aims to summarise relevant clinical trial evidence concerning the role and safety of new glucose-lowering therapies in patients with HF. © 2019 The Authors. European Journal of Heart Failure © 2019 European Society of Cardiology
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- 2020
44. Epidemiology, pathophysiology and contemporary management of cardiogenic shock – a position statement from the Heart Failure Association of the European Society of Cardiology
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Chioncel, O. Parissis, J. Mebazaa, A. Thiele, H. Desch, S. Bauersachs, J. Harjola, V.-P. Antohi, E.-L. Arrigo, M. Gal, T.B. Celutkiene, J. Collins, S.P. DeBacker, D. Iliescu, V.A. Jankowska, E. Jaarsma, T. Keramida, K. Lainscak, M. Lund, L.H. Lyon, A.R. Masip, J. Metra, M. Miro, O. Mortara, A. Mueller, C. Mullens, W. Nikolaou, M. Piepoli, M. Price, S. Rosano, G. Vieillard-Baron, A. Weinstein, J.M. Anker, S.D. Filippatos, G. Ruschitzka, F. Coats, A.J.S. Seferovic, P.
- Abstract
Cardiogenic shock (CS) is a complex multifactorial clinical syndrome with extremely high mortality, developing as a continuum, and progressing from the initial insult (underlying cause) to the subsequent occurrence of organ failure and death. There is a large spectrum of CS presentations resulting from the interaction between an acute cardiac insult and a patient's underlying cardiac and overall medical condition. Phenotyping patients with CS may have clinical impact on management because classification would support initiation of appropriate therapies. CS management should consider appropriate organization of the health care services, and therapies must be given to the appropriately selected patients, in a timely manner, whilst avoiding iatrogenic harm. Although several consensus-driven algorithms have been proposed, CS management remains challenging and substantial investments in research and development have not yielded proof of efficacy and safety for most of the therapies tested, and outcome in this condition remains poor. Future studies should consider the identification of the new pathophysiological targets, and high-quality translational research should facilitate incorporation of more targeted interventions in clinical research protocols, aimed to improve individual patient outcomes. Designing outcome clinical trials in CS remains particularly challenging in this critical and very costly scenario in cardiology, but information from these trials is imperiously needed to better inform the guidelines and clinical practice. The goal of this review is to summarize the current knowledge concerning the definition, epidemiology, underlying causes, pathophysiology and management of CS based on important lessons from clinical trials and registries, with a focus on improving in-hospital management. © 2020 European Society of Cardiology
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- 2020
45. Unravelling the interplay between hyperkalaemia, renin–angiotensin–aldosterone inhibitor use and clinical outcomes. Data from 9222 chronic heart failure patients of the ESC-HFA-EORP Heart Failure Long-Term Registry
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Rossignol, P. Lainscak, M. Crespo-Leiro, M.G. Laroche, C. Piepoli, M.F. Filippatos, G. Rosano, G.M.C. Savarese, G. Anker, S.D. Seferovic, P.M. Ruschitzka, F. Coats, A.J.S. Mebazaa, A. McDonagh, T. Sahuquillo, A. Penco, M. Maggioni, A.P. Lund, L.H. Christopher Peter Gale, G.B. Branko Beleslin, R.S. Andrzej Budaj, P.L. Ovidiu Chioncel, R.O. Nikolaos Dagres, D.E. Nicolas Danchin, F.R. David Erlinge, S.E. Jonathan Emberson, G.B. Michael Glikson, I.L. Alastair Gray, G.B. Meral Kayikcioglu, T.R. Aldo Maggioni, I.T. Klaudia Vivien Nagy, H.U. Aleksandr Nedoshivin, R.U. Anna-Sonia Petronio, I.T. Jolien Roos-Hesselink, N.L. Lars Wallentin, S.E. Uwe Zeymer, D.E. Anker, S. Mebazaa, A. Coats, A. Filippatos, G. Ferrari, R. Maggioni, A.P. Goda, A. Diez, M. Fernandez, A. Fruhwald, F. Fazlibegovic, E. Gatzov, P. Kurlianskaya, A. Hullin, R. Christodoulides, T. Hradec, J. Nielsen, O.W. Nedjar, R. Uuetoa, T. Hassanein, M. Jimenez, J.F.D. Harjola, V.P. Logeart, D. Chumburidze, V. Tousoulis, D. Milicic, D. Merkely, B. O'Donoghue, E. Amir, O. Shotan, A. Shafie, D. Metra, M. Matsumori, A. Mirrakhimov, E. Kavoliuniene, A. Erglis, A. Vataman, E. Otljanska, M. Kostovska, E.S. DeMarco, D.C. Drozdz, J. Fonseca, C. Chioncel, O. Dekleva, M. Shkolnik, E. Dahlstrom, U. Lainscak, M. Goncalvesova, E. Temizhan, A. Estrago, V. Bajraktari, G. Auer, J. Ablasser, K. Fruhwald, F. Dolze, T. Brandner, K. Gstrein, S. Poelzl, G. Moertl, D. Reiter, S. Podczeck-Schweighofer, A. Muslibegovic, A. Vasilj, M. Fazlibegovic, E. Cesko, M. Zelenika, D. Palic, B. Pravdic, D. Cuk, D. Vitlianova, K. Katova, T. Velikov, T. Kurteva, T. Gatzov, P. Kamenova, D. Antova, M. Sirakova, V. Krejci, J. Mikolaskova, M. Spinar, J. Krupicka, J. Malek, F. Hegarova, M. Lazarova, M. Monhart, Z. Hassanein, M. Sobhy, M. El Messiry, F. El Shazly, A.H. Elrakshy, Y. Youssef, A. Moneim, A.A. Noamany, M. Reda, A. Dayem, T.K.A. Farag, N. Halawa, S.I. Hamid, M.A. Said, K. Saleh, A. Ebeid, H. Hanna, R. Aziz, R. Louis, O. Enen, M.A. Ibrahim, B.S. Nasr, G. Elbahry, A. Sobhy, H. Ashmawy, M. Gouda, M. Aboleineen, W. Bernard, Y. Luporsi, P. Meneveau, N. Pillot, M. Morel, M. Seronde, M.-F. Schiele, F. Briand, F. Delahaye, F. Damy, T. Eicher, J.-C. de Groote, P. Fertin, M. Lamblin, N. Isnard, R. Lefol, C. Thevenin, S. Hagege, A. Jondeau, G. Logeart, D. Le Marcis, V. Ly, J.-F. Coisne, D. Lequeux, B. Le Moal, V. Mascle, S. Lotton, P. Behar, N. Donal, E. Thebault, C. Ridard, C. Reynaud, A. Basquin, A. Bauer, F. Codjia, R. Galinier, M. Tourikis, P. Stavroula, M. Tousoulis, D. Stefanadis, C. Chrysohoou, C. Kotrogiannis, I. Matzaraki, V. Dimitroula, T. Karavidas, A. Tsitsinakis, G. Kapelios, C. Nanas, J. Kampouri, H. Nana, E. Kaldara, E. Eugenidou, A. Vardas, P. Saloustros, I. Patrianakos, A. Tsaknakis, T. Evangelou, S. Nikoloulis, N. Tziourganou, H. Tsaroucha, A. Papadopoulou, A. Douras, A. Polgar, L. Kosztin, A. Nyolczas, N. Nagy, A.C. Halmosi, R. Elber, J. Alony, I. Shotan, A. Fuhrmann, A.V. Amir, O. Romano, S. Marcon, S. Penco, M. Di Mauro, M. Lemme, E. Carubelli, V. Rovetta, R. Bulgari, M. Quinzani, F. Lombardi, C. Bosi, S. Schiavina, G. Squeri, A. Barbieri, A. Di Tano, G. Pirelli, S. Ferrari, R. Fucili, A. Passero, T. Musio, S. Di Biase, M. Correale, M. Salvemini, G. Brognoli, S. Zanelli, E. Giordano, A. Agostoni, P. Italiano, G. Salvioni, E. Copelli, S. Modena, M.G. Reggianini, L. Valenti, C. Olaru, A. Bandino, S. Deidda, M. Mercuro, G. Dessalvi, C.C. Marino, P.N. Di Ruocco, M.V. Sartori, C. Piccinino, C. Parrinello, G. Licata, G. Torres, D. Giambanco, S. Busalacchi, S. Arrotti, S. Novo, S. Inciardi, R.M. Pieri, P. Chirco, P.R. Galifi, M.A. Teresi, G. Buccheri, D. Minacapelli, A. Veniani, M. Frisinghelli, A. Priori, S.G. Cattaneo, S. Opasich, C. Gualco, A. Pagliaro, M. Mancone, M. Fedele, F. Cinque, A. Vellini, M. Scarfo, I. Romeo, F. Ferraiuolo, F. Sergi, D. Anselmi, M. Melandri, F. Leci, E. Iori, E. Bovolo, V. Pidello, S. Frea, S. Bergerone, S. Botta, M. Canavosio, F.G. Gaita, F. Merlo, M. Cinquetti, M. Sinagra, G. Ramani, F. Fabris, E. Stolfo, D. Artico, J. Miani, D. Fresco, C. Daneluzzi, C. Proclemer, A. Cicoira, M. Zanolla, L. Marchese, G. Torelli, F. Vassanelli, C. Voronina, N. Tamakauskas, V. Smalinskas, V. Karaliute, R. Petraskiene, I. Kazakauskaite, E. Rumbinaite, E. Kavoliuniene, A. Vysniauskas, V. Brazyte-Ramanauskiene, R. Petraskiene, D. Stankala, S. Switala, P. Juszczyk, Z. Sinkiewicz, W. Gilewski, W. Pietrzak, J. Orzel, T. Kasztelowicz, P. Kardaszewicz, P. Lazorko-Piega, M. Gabryel, J. Mosakowska, K. Bellwon, J. Rynkiewicz, A. Raczak, G. Lewicka, E. Dabrowska-Kugacka, A. Bartkowiak, R. Sosnowska-Pasiarska, B. Wozakowska-Kaplon, B. Krzeminski, A. Zabojszcz, M. Mirek-Bryniarska, E. Grzegorzko, A. Bury, K. Nessler, J. Zalewski, J. Furman, A. Broncel, M. Poliwczak, A. Bala, A. Zycinski, P. Rudzinska, M. Jankowski, L. Kasprzak, J.D. Michalak, L. Soska, K.W. Drozdz, J. Huziuk, I. Retwinski, A. Flis, P. Weglarz, J. Bodys, A. Grajek, S. Kaluzna-Oleksy, M. Straburzynska-Migaj, E. Dankowski, R. Szymanowska, K. Grabia, J. Szyszka, A. Nowicka, A. Samcik, M. Wolniewicz, L. Baczynska, K. Komorowska, K. Poprawa, I. Komorowska, E. Sajnaga, D. Zolbach, A. Dudzik-Plocica, A. Abdulkarim, A.-F. Lauko-Rachocka, A. Kaminski, L. Kostka, A. Cichy, A. Ruszkowski, P. Splawski, M. Fitas, G. Szymczyk, A. Serwicka, A. Fiega, A. Zysko, D. Krysiak, W. Szabowski, S. Skorek, E. Pruszczyk, P. Bienias, P. Ciurzynski, M. Welnicki, M. Mamcarz, A. Folga, A. Zielinski, T. Rywik, T. Leszek, P. Sobieszczanska-Malek, M. Piotrowska, M. Kozar-Kaminska, K. Komuda, K. Wisniewska, J. Tarnowska, A. Balsam, P. Marchel, M. Opolski, G. Kaplon-Cieslicka, A. Gil, R.J. Mozenska, O. Byczkowska, K. Gil, K. Pawlak, A. Michalek, A. Krzesinski, P. Piotrowicz, K. Uzieblo-Zyczkowska, B. Stanczyk, A. Skrobowski, A. Ponikowski, P. Jankowska, E. Rozentryt, P. Polonski, L. Gadula-Gacek, E. Nowalany-Kozielska, E. Kuczaj, A. Kalarus, Z. Szulik, M. Przybylska, K. Klys, J. Prokop-Lewicka, G. Kleinrok, A. Aguiar, C.T. Ventosa, A. Pereira, S. Faria, R. Chin, J. De Jesus, I. Santos, R. Silva, P. Moreno, N. Queirós, C. Lourenço, C. Pereira, A. Castro, A. Andrade, A. Guimaraes, T.O. Martins, S. Placido, R. Lima, G. Brito, D. Francisco, A.R. Cardiga, R. Proenca, M. Araujo, I. Marques, F. Fonseca, C. Moura, B. Leite, S. Campelo, M. Silva-Cardoso, J. Rodrigues, J. Rangel, I. Martins, E. Correia, A.S. Peres, M. Marta, L. da Silva, G.F. Severino, D. Durao, D. Leao, S. Magalhaes, P. Moreira, I. Cordeiro, A.F. Ferreira, C. Araujo, C. Ferreira, A. Baptista, A. Radoi, M. Bicescu, G. Vinereanu, D. Sinescu, C.-J. Macarie, C. Popescu, R. Daha, I. Dan, G.-A. Stanescu, C. Dan, A. Craiu, E. Nechita, E. Aursulesei, V. Christodorescu, R. Otasevic, P. Seferovic, P.M. Simeunovic, D. Ristic, A.D. Celic, V. Pavlovic-Kleut, M. Lazic, J.S. Stojcevski, B. Pencic, B. Stevanovic, A. Andric, A. Simić, D. Ašanin, M. Iric-Cupic, V. Jovic, M. Davidovic, G. Milanov, S. Mitic, V. Atanaskovic, V. Antic, S. Pavlovic, M. Stanojevic, D. Stoickov, V. Ilic, S. Ilic, M.D. Petrovic, D. Stojsic, S. Kecojevic, S. Dodic, S. Adic, N.C. Cankovic, M. Stojiljkovic, J. Mihajlovic, B. Radin, A. Radovanovic, S. Krotin, M. Klabnik, A. Goncalvesova, E. Pernicky, M. Murin, J. Kovar, F. Kmec, J. Semjanova, H. Strasek, M. Iskra, M.S. Ravnikar, T. Suligoj, N.C. Komel, J. Fras, Z. Jug, B. Glavic, T. Losic, R. Bombek, M. Krajnc, I. Krunic, B. Horvat, S. Kovac, D. Rajtman, D. Cencic, V. Letonja, M. Winkler, R. Valentincic, M. Melihen-Bartolic, C. Bartolic, A. Vrckovnik, M.P. Kladnik, M. Pusnik, C.S. Marolt, A. Klen, J. Drnovsek, B. Leskovar, B. Anguita, M.J.F. Page, J.C.G. Martinez, F.M.S. Andres, J. Bayes-Genis, A. Mirabet, S. Mendez, A. Garcia-Cosio, L. Roig, E. Leon, V. Gonzalez-Costello, J. Muntane, G. Garay, A. Alcade-Martinez, V. Fernandez, S.L. Rivera-Lopez, R. Puga-Martinez, M. Fernandez-Alvarez, M. Serrano-Martinez, J.L. Grille-Cancela, Z. Marzoa-Rivas, R. Blanco-Canosa, P. Paniagua-Martin, M.J. Barge-Caballero, E. Cerdena, I.L. Baldomero, I.F.H. Padron, A.L. Rosillo, S.O. Gonzalez-Gallarza, R.D. Montanes, O.S. Manjavacas, A.M.I. Conde, A.C. Araujo, A. Soria, T. Garcia-Pavia, P. Gomez-Bueno, M. Cobo-Marcos, M. Alonso-Pulpon, L. Cubero, J.S. Sayago, I. Gonzalez-Segovia, A. Briceno, A. Subias, P.E. Hernandez, M.V. Cano, M.J.R. Sanchez, M.A.G. Jimenez, J.F.D. Garrido-Lestache, E.B. Pinilla, J.M.G. de la Villa, B.G. Sahuquillo, A. Marques, R.B. Calvo, F.T. Perez-Martinez, M.T. Gracia-Rodenas, M.R. Garrido-Bravo, I.P. Pastor-Perez, F. Pascual-Figal, D.A. Molina, B.D. Orus, J. Gonzalo, F.E. Bertomeu, V. Valero, R. Martinez-Abellan, R. Quiles, J. Rodrigez-Ortega, J.A. Mateo, I. ElAmrani, A. Fernandez-Vivancos, C. Valero, D.B. Almenar-Bonet, L. Sanchez-Lazaro, I.J. Marques-Sule, E. Facila-Rubio, L. Perez-Silvestre, J. Garcia-Gonzalez, P. Ridocci-Soriano, F. Garcia-Escriva, D. Pellicer-Cabo, A. de la Fuente Galan, L. Diaz, J.L. Platero, A.R. Arias, J.C. Blasco-Peiro, T. Julve, M.S. Sanchez-Insa, E. Aured-Guallar, C. Portoles-Ocampo, A. Melin, M. Hägglund, E. Stenberg, A. Lindahl, I.-M. Asserlund, B. Olsson, L. Dahlström, U. Afzelius, M. Karlström, P. Tengvall, L. Olsson, B. Kalayci, S. Temizhan, A. Cavusoglu, Y. Gencer, E. Yilmaz, M.B. Gunes, H.
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cardiovascular diseases - Abstract
Aims: We assessed the interplay between hyperkalaemia (HK) and renin–angiotensin–aldosterone system inhibitor (RAASi) use, dose and discontinuation, and their association with all-cause or cardiovascular death in patients with chronic heart failure (HF). We hypothesized that HK-associated increased death may be related to RAASi withdrawal. Methods and results: The ESC-HFA-EORP Heart Failure Long-Term Registry was used. Among 9222 outpatients (HF with reduced ejection fraction: 60.6%, HF with mid-range ejection fraction: 22.9%, HF with preserved ejection fraction: 16.5%) from 31 countries, 16.6% had HK (≥5.0 mmol/L) at baseline. Angiotensin-converting enzyme inhibitor (ACEi) or angiotensin receptor blocker (ARB) was used in 88.3%, a mineralocorticoid receptor antagonist (MRA) in 58.7%, or a combination in 53.2%; of these, at ≥50% of target dose in ACEi: 61.8%; ARB: 64.7%; and MRA: 90.3%. At a median follow-up of 12.2 months, there were 789 deaths (8.6%). Both hypokalaemia and HK were independently. associated with higher mortality, and ACEi/ARB prescription at baseline with lower mortality. MRA prescription was not retained in the model. In multivariable analyses, HK at baseline was independently associated with MRA non-prescription at baseline and subsequent discontinuation. When considering subsequent discontinuation of RAASi (instead of baseline use), HK was no longer found associated with all-cause deaths. Importantly, all RAASi (ACEi, ARB, or MRA) discontinuations were strongly associated with mortality. Conclusions: In HF, hyper- and hypokalaemia were associated with mortality. However, when adjusting for RAASi discontinuation, HK was no longer associated with mortality, suggesting that HK may be a risk marker for RAASi discontinuation rather than a risk factor for worse outcomes. © 2020 European Society of Cardiology
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- 2020
46. Sodium–glucose co-transporter 2 inhibitors in heart failure: beyond glycaemic control. A position paper of the Heart Failure Association of the European Society of Cardiology
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Seferović, P.M. Fragasso, G. Petrie, M. Mullens, W. Ferrari, R. Thum, T. Bauersachs, J. Anker, S.D. Ray, R. Çavuşoğlu, Y. Polovina, M. Metra, M. Ambrosio, G. Prasad, K. Seferović, J. Jhund, P.S. Dattilo, G. Čelutkiene, J. Piepoli, M. Moura, B. Chioncel, O. Ben Gal, T. Heymans, S. de Boer, R.A. Jaarsma, T. Hill, L. Lopatin, Y. Lyon, A.R. Ponikowski, P. Lainščak, M. Jankowska, E. Mueller, C. Cosentino, F. Lund, L. Filippatos, G.S. Ruschitzka, F. Coats, A.J.S. Rosano, G.M.C.
- Abstract
Heart failure (HF) is common and associated with a poor prognosis, despite advances in treatment. Over the last decade cardiovascular outcome trials with sodium–glucose co-transporter 2 (SGLT2) inhibitors in patients with type 2 diabetes mellitus have demonstrated beneficial effects for three SGLT2 inhibitors (empagliflozin, canagliflozin and dapagliflozin) in reducing hospitalisations for HF. More recently, dapagliflozin reduced the risk of worsening HF or death from cardiovascular causes in patients with chronic HF with reduced left ventricular ejection fraction, with or without type 2 diabetes mellitus. A number of additional trials in HF patients with reduced and/or preserved left ventricular ejection fraction are ongoing and/or about to be reported. The present position paper summarises recent clinical trial evidence and discusses the role of SGLT2 inhibitors in the treatment of HF, pending the results of ongoing trials in different populations of patients with HF. © 2020 European Society of Cardiology
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- 2020
47. Baseline cardiovascular risk assessment in cancer patients scheduled to receive cardiotoxic cancer therapies: a position statement and new risk assessment tools from theCardio-OncologyStudyGroup of theHeartFailureAssociation of theEuropeanSociety ofCardiology in collaboration with theInternationalCardio-OncologySociety
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Lyon, AR, Dent, S, Stanway, S, Earl, H, Brezden-Masley, C, Cohen-Solal, A, Tocchetti, CG, Moslehi, JJ, Groarke, JD, Bergler-Klein, J, Khoo, V, Tan, LL, Anker, MS, von Haehling, S, Maack, C, Pudil, R, Barac, A, Thavendiranathan, P, Ky, B, Neilan, TG, Belenkov, Y, Rosen, SD, Iakobishvili, Z, Sverdlov, AL, Hajjar, LA, Macedo, AVS, Manisty, C, Ciardiello, F, Farmakis, D, de Boer, RA, Skouri, H, Suter, TM, Cardinale, D, Witteles, RM, Fradley, MG, Herrmann, J, Cornell, RF, Wechelaker, A, Mauro, MJ, Milojkovic, D, de Lavallade, H, Ruschitzka, F, Coats, AJS, Seferovic, PM, Chioncel, O, Thum, T, Bauersachs, J, Andres, MS, Wright, DJ, Lopez-Fernandez, T, Plummer, C, Lenihan, D, Lyon, AR, Dent, S, Stanway, S, Earl, H, Brezden-Masley, C, Cohen-Solal, A, Tocchetti, CG, Moslehi, JJ, Groarke, JD, Bergler-Klein, J, Khoo, V, Tan, LL, Anker, MS, von Haehling, S, Maack, C, Pudil, R, Barac, A, Thavendiranathan, P, Ky, B, Neilan, TG, Belenkov, Y, Rosen, SD, Iakobishvili, Z, Sverdlov, AL, Hajjar, LA, Macedo, AVS, Manisty, C, Ciardiello, F, Farmakis, D, de Boer, RA, Skouri, H, Suter, TM, Cardinale, D, Witteles, RM, Fradley, MG, Herrmann, J, Cornell, RF, Wechelaker, A, Mauro, MJ, Milojkovic, D, de Lavallade, H, Ruschitzka, F, Coats, AJS, Seferovic, PM, Chioncel, O, Thum, T, Bauersachs, J, Andres, MS, Wright, DJ, Lopez-Fernandez, T, Plummer, C, and Lenihan, D
- Abstract
This position statement from the Heart Failure Association of the European Society of Cardiology Cardio-Oncology Study Group in collaboration with the International Cardio-Oncology Society presents practical, easy-to-use and evidence-based risk stratification tools for oncologists, haemato-oncologists and cardiologists to use in their clinical practice to risk stratify oncology patients prior to receiving cancer therapies known to cause heart failure or other serious cardiovascular toxicities. Baseline risk stratification proformas are presented for oncology patients prior to receiving the following cancer therapies: anthracycline chemotherapy, HER2-targeted therapies such as trastuzumab, vascular endothelial growth factor inhibitors, second and third generation multi-targeted kinase inhibitors for chronic myeloid leukaemia targeting BCR-ABL, multiple myeloma therapies (proteasome inhibitors and immunomodulatory drugs), RAF and MEK inhibitors or androgen deprivation therapies. Applying these risk stratification proformas will allow clinicians to stratify cancer patients into low, medium, high and very high risk of cardiovascular complications prior to starting treatment, with the aim of improving personalised approaches to minimise the risk of cardiovascular toxicity from cancer therapies.
- Published
- 2020
48. Role of cardiovascular imaging in cancer patients receiving cardiotoxic therapies: a position statement on behalf of the Heart Failure Association (HFA), the European Association of Cardiovascular Imaging (EACVI) and the Cardio-Oncology Council of the European Society of Cardiology (ESC)
- Author
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Celutkiene, J, Pudil, R, Lopez-Fernandez, T, Grapsa, J, Nihoyannopoulos, P, Bergler-Klein, J, Cohen-Solal, A, Farmakis, D, Tocchetti, CG, von Haehling, S, Barberis, V, Flachskampf, FA, Ceponiene, I, Haegler-Laube, E, Suter, T, Lapinskas, T, Prasad, S, de Boer, RA, Wechalekar, K, Anker, MS, Iakobishvili, Z, Bucciarelli-Ducci, C, Schulz-Menger, J, Cosyns, B, Gaemperli, O, Belenkov, Y, Hulot, J-S, Galderisi, M, Lancellotti, P, Bax, J, Marwick, TH, Chioncel, O, Jaarsma, T, Mullens, W, Piepoli, M, Thum, T, Heymans, S, Mueller, C, Moura, B, Ruschitzka, F, Zamorano, JL, Rosano, G, Coats, AJS, Asteggiano, R, Seferovic, P, Edvardsen, T, Lyon, AR, Celutkiene, J, Pudil, R, Lopez-Fernandez, T, Grapsa, J, Nihoyannopoulos, P, Bergler-Klein, J, Cohen-Solal, A, Farmakis, D, Tocchetti, CG, von Haehling, S, Barberis, V, Flachskampf, FA, Ceponiene, I, Haegler-Laube, E, Suter, T, Lapinskas, T, Prasad, S, de Boer, RA, Wechalekar, K, Anker, MS, Iakobishvili, Z, Bucciarelli-Ducci, C, Schulz-Menger, J, Cosyns, B, Gaemperli, O, Belenkov, Y, Hulot, J-S, Galderisi, M, Lancellotti, P, Bax, J, Marwick, TH, Chioncel, O, Jaarsma, T, Mullens, W, Piepoli, M, Thum, T, Heymans, S, Mueller, C, Moura, B, Ruschitzka, F, Zamorano, JL, Rosano, G, Coats, AJS, Asteggiano, R, Seferovic, P, Edvardsen, T, and Lyon, AR
- Abstract
Cardiovascular (CV) imaging is an important tool in baseline risk assessment and detection of CV disease in oncology patients receiving cardiotoxic cancer therapies. This position statement examines the role of echocardiography, cardiac magnetic resonance, nuclear cardiac imaging and computed tomography in the management of cancer patients. The Imaging and Cardio-Oncology Study Groups of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) in collaboration with the European Association of Cardiovascular Imaging (EACVI) and the Cardio-Oncology Council of the ESC have evaluated the current evidence for the value of modern CV imaging in the cardio-oncology field. The most relevant echocardiographic parameters, including global longitudinal strain and three-dimensional ejection fraction, are proposed. The protocol for baseline pre-treatment evaluation and specific surveillance algorithms or pathways for anthracycline chemotherapy, HER2-targeted therapies such as trastuzumab, vascular endothelial growth factor tyrosine kinase inhibitors, BCr-Abl tyrosine kinase inhibitors, proteasome inhibitors and immune checkpoint inhibitors are presented. The indications for CV imaging after completion of oncology treatment are considered. The typical consequences of radiation therapy and the possibility of their identification in the long term are also summarized. Special populations are discussed including female survivors planning pregnancy, patients with carcinoid disease, patients with cardiac tumours and patients with right heart failure. Future directions and ongoing CV imaging research in cardio-oncology are discussed.
- Published
- 2020
49. Left atrial dysfunction in patients with prosthesis-patient mismatch after transcatheter aortic valve replacement
- Author
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Cadil, D, primary, Calin, A, additional, Parasca, CA, additional, Mateescu, A, additional, Rosca, M, additional, Enache, R, additional, Beladan, C, additional, Ginghina, C, additional, Deleanu, D, additional, Chioncel, O, additional, Bubenek, S, additional, Iliescu, V, additional, and Popescu, BA, additional
- Published
- 2021
- Full Text
- View/download PDF
50. ROTEM-based Point-of-care Coagulation Management in Patients with Acute Aortic Dissection: P73
- Author
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Filipescu, D., Marinica, I., Luchian, M., Paunescu, A., Marin, S., Manofu, C., and Chioncel, O.
- Published
- 2013
- Full Text
- View/download PDF
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