Search

Your search keyword '"Chiocchia, Virginia"' showing total 132 results
Start Over Author "Chiocchia, Virginia"
132 results on '"Chiocchia, Virginia"'

3. PROTEUS Study: A Prospective Randomized Controlled Trial Evaluating the Use of Artificial Intelligence in Stress Echocardiography

Author

Woodward, Gary, Bajre, Mamta, Bhattacharyya, Sanjeev, Breen, Maria, Chiocchia, Virginia, Dawes, Helen, Dehbi, Hakim-Moulay, Descamps, Tine, Frangou, Elena, Fazakarley, Carol-Ann, Harris, Victoria, Hawkes, Will, Hewer, Oliver, Johnson, Casey L, Krasner, Samuel, Laidlaw, Lynn, Lau, Jonathan, Marwick, Tom, Petersen, Steffen E, Piotrowska, Hania, Ridgeway, Ged, Ripley, David P, Sanderson, Emily, Savage, Natalie, Sarwar, Rizwan, Tetlow, Louise, Thompson, Ben, Thulborn, Samantha, Williamson, Victoria, Woodward, William, Upton, Ross, and Leeson, Paul

Published
2023
Full Text
View/download PDF

4. Trace amine-associated receptor 1 (TAAR1) agonism for psychosis: a living systematic review and meta-analysis of human and non-human data

Author

Siafis, Spyridon, primary, Chiocchia, Virginia, additional, Macleod, Malcolm R., additional, Austin, Charlotte, additional, Homiar, Ava, additional, Tinsdeall, Francesca, additional, Friedrich, Claire, additional, Ramage, Fiona J., additional, Kennett, Jaycee, additional, Nomura, Nobuyuki, additional, Maksym, Olena, additional, Rutigliano, Grazia, additional, Vano, Luke J., additional, McCutcheon, Robert A., additional, Gilbert, David, additional, Ostinelli, Edoardo G., additional, Stansfield, Claire, additional, Dehdarirad, Hossein, additional, Juma, Damian Omari, additional, Wright, Simonne, additional, Simple, Ouma, additional, Elugbadebo, Olufisayo, additional, Tonia, Thomy, additional, Mantas, Ioannis, additional, Howes, Oliver D., additional, Furukawa, Toshi A., additional, Milligan, Lea, additional, Moreno, Carmen, additional, Elliott, Julian H., additional, Hastings, Janna, additional, Thomas, James, additional, Michie, Susan, additional, Sena, Emily S., additional, Seedat, Soraya, additional, Egger, Matthias, additional, Potts, Jennifer, additional, Cipriani, Andrea, additional, Salanti, Georgia, additional, and Leucht, Stefan, additional

Published
2024
Full Text
View/download PDF

5. Network Meta-Analysis Results against a Fictional Treatment of Average Performance: Treatment Effects and Ranking Metric

Author

Nikolakopoulou, Adriani, Mavridis, Dimitris, Chiocchia, Virginia, Papakonstantinou, Theodoros, Furukawa, Toshi A., and Salanti, Georgia

Abstract

Background: Network meta-analysis (NMA) produces complex outputs as many comparisons between interventions are of interest. The estimated relative treatment effects are usually displayed in a forest plot or in a league table and several ranking metrics are calculated and presented. Methods: In this article, we estimate relative treatment effects of each competing treatment against a fictional treatment of average performance using the "deviation from the means" coding that has been used to parametrize categorical covariates in regression models. We then use this alternative parametrization of the NMA model to present a ranking metric (PreTA: Preferable Than Average) interpreted as the probability that a treatment is better than a fictional treatment of average performance. Results: We illustrate the alternative parametrization of the NMA model using two networks of interventions, a network of 18 antidepressants for acute depression and a network of four interventions for heavy menstrual bleeding. We also use these two networks to highlight differences among PreTA and existing ranking metrics. We further examine the agreement between PreTA and existing ranking metrics in 232 networks of interventions and conclude that their agreement depends on the precision with which relative effects are estimated. Conclusions: A forest plot with NMA relative treatment effects using "deviation from means" coding could complement presentation of NMA results in large networks and in absence of an obvious reference treatment. PreTA is a viable alternative to existing probabilistic ranking metrics that naturally incorporates uncertainty.

Published
2021
Full Text
View/download PDF

6. Techniques to increase lumbar puncture success in newborn babies: the NeoCLEAR RCT

Author

Roehr, Charles C, primary, Marshall, Andrew SJ, additional, Scrivens, Alexandra, additional, Sadarangani, Manish, additional, Williams, Rachel, additional, Yong, Jean, additional, Linsell, Louise, additional, Chiocchia, Virginia, additional, Bell, Jennifer L, additional, Stokes, Caz, additional, Santhanadass, Patricia, additional, Nicoll, Ian, additional, Adams, Eleri, additional, King, Andrew, additional, Murray, David, additional, Bowler, Ursula, additional, Stanbury, Kayleigh, additional, and Juszczak, Edmund, additional

Published
2023
Full Text
View/download PDF

8. New living evidence resource of human and non-human studies for early intervention and research prioritisation in anxiety, depression and psychosis

Author

Cipriani, Andrea, primary, Seedat, Soraya, additional, Milligan, Lea, additional, Salanti, Georgia, additional, Macleod, Malcolm, additional, Hastings, Janna, additional, Thomas, James, additional, Michie, Susan, additional, Furukawa, Toshi A, additional, Gilbert, David, additional, Soares-Weiser, Karla, additional, Moreno, Carmen, additional, Leucht, Stefan, additional, Egger, Matthias, additional, Mansoori, Parisa, additional, Barker, James M, additional, Siafis, Spyridon, additional, Ostinelli, Edoardo Giuseppe, additional, McCutcheon, Robert, additional, Wright, Simonne, additional, Simpson, Matilda, additional, Elugbadebo, Olufisayo, additional, Chiocchia, Virginia, additional, Tonia, Thomy, additional, Elgarf, Rania, additional, Kurtulmus, Ayse, additional, Sena, Emily, additional, Simple, Ouma, additional, Boyce, Niall, additional, Chung, Sophie, additional, Sharma, Anjuli, additional, Wolpert, Miranda, additional, Potts, Jennifer, additional, and Elliott, Julian H, additional

Published
2023
Full Text
View/download PDF

11. New living evidence resource of human and non-human studies for early intervention and research prioritisation in anxiety, depression and psychosis [perspective]

Author

Cipriani, Andrea, Seedat, Soraya, Milligan, Lea, Salanti, Georgia, Macleod, Malcolm, Hastings, Janna, Thomas, James, Michie, Susan, Furukawa, Toshi A, Gilbert, David, Soares-Weiser, Karla, Moreno, Carmen, Leucht, Stefan, Egger, Matthias, Mansoori, Parisa, Barker, James M, Siafis, Spyridon, Ostinelli, Edoardo Giuseppe, McCutcheon, Robert, Wright, Simonne, Simpson, Matilda, Elugbadebo, Olufisayo, Chiocchia, Virginia, Tonia, Thomy, Elgarf, Rania, Kurtulmus, Ayse, Sena, Emily, Simple, Ouma, Boyce, Niall, Chung, Sophie, Sharma, Anjuli, Wolpert, Miranda, Potts, Jennifer, and Elliott, Julian H

Subjects
360 Social problems & social services, 610 Medicine & health
Abstract

In anxiety, depression and psychosis, there has been frustratingly slow progress in developing novel therapies that make a substantial difference in practice, as well as in predicting which treatments will work for whom and in what contexts. To intervene early in the process and deliver optimal care to patients, we need to understand the underlying mechanisms of mental health conditions, develop safe and effective interventions that target these mechanisms, and improve our capabilities in timely diagnosis and reliable prediction of symptom trajectories. Better synthesis of existing evidence is one way to reduce waste and improve efficiency in research towards these ends. Living systematic reviews produce rigorous, up-to-date and informative evidence summaries that are particularly important where research is emerging rapidly, current evidence is uncertain and new findings might change policy or practice. Global Alliance for Living Evidence on aNxiety, depressiOn and pSychosis (GALENOS) aims to tackle the challenges of mental health science research by cataloguing and evaluating the full spectrum of relevant scientific research including both human and preclinical studies. GALENOS will also allow the mental health community-including patients, carers, clinicians, researchers and funders-to better identify the research questions that most urgently need to be answered. By creating open-access datasets and outputs in a state-of-the-art online resource, GALENOS will help identify promising signals early in the research process. This will accelerate translation from discovery science into effective new interventions for anxiety, depression and psychosis, ready to be translated in clinical practice across the world.

Published
2023

13. A randomized trial of normothermic preservation in liver transplantation

Author

Nasralla, David, Coussios, Constantin C., Mergental, Hynek, Akhtar, M. Zeeshan, Butler, Andrew J., Ceresa, Carlo D. L., and Chiocchia, Virginia

Subjects
Liver transplantation -- Methods, Aspartate, Enzymes, Surgery, Organ transplantation, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Liver transplantation is a highly successful treatment, but is severely limited by the shortage in donor organs. However, many potential donor organs cannot be used; this is because sub-optimal livers do not tolerate conventional cold storage and there is no reliable way to assess organ viability preoperatively. Normothermic machine perfusion maintains the liver in a physiological state, avoids cooling and allows recovery and functional testing. Here we show that, in a randomized trial with 220 liver transplantations, compared to conventional static cold storage, normothermic preservation is associated with a 50% lower level of graft injury, measured by hepatocellular enzyme release, despite a 50% lower rate of organ discard and a 54% longer mean preservation time. There was no significant difference in bile duct complications, graft survival or survival of the patient. If translated to clinical practice, these results would have a major impact on liver transplant outcomes and waiting list mortality.Normothermic machine perfusion of the liver improved early graft function, demonstrated by reduced peak serum aspartate transaminase levels and early allograft dysfunction rates, and improved organ utilization and preservation times, although no differences were seen in graft or patient survival., Author(s): David Nasralla [sup.1] , Constantin C. Coussios [sup.2] , Hynek Mergental [sup.3] , M. Zeeshan Akhtar [sup.1] [sup.4] , Andrew J. Butler [sup.5] , Carlo D. L. Ceresa [sup.1] [...]

Published
2018
Full Text
View/download PDF

14. Metabolic side effects in persons with schizophrenia during mid‐ to long‐term treatment with antipsychotics: a network meta‐analysis of randomized controlled trials

Author

Burschinski, Angelika, primary, Schneider‐Thoma, Johannes, additional, Chiocchia, Virginia, additional, Schestag, Kristina, additional, Wang, Dongfang, additional, Siafis, Spyridon, additional, Bighelli, Irene, additional, Wu, Hui, additional, Hansen, Wulf‐Peter, additional, Priller, Josef, additional, Davis, John M., additional, Salanti, Georgia, additional, and Leucht, Stefan, additional

Published
2023
Full Text
View/download PDF

15. Planned delivery for pre-eclampsia between 34 and 37 weeks of gestation: the PHOENIX RCT

Author

Chappell, Lucy C, primary, Brocklehurst, Peter, additional, Green, Marcus, additional, Hardy, Pollyanna, additional, Hunter, Rachael, additional, Beardmore-Gray, Alice, additional, Bowler, Ursula, additional, Brockbank, Anna, additional, Chiocchia, Virginia, additional, Cox, Alice, additional, Duhig, Kate, additional, Fleminger, Jessica, additional, Gill, Carolyn, additional, Greenland, Melanie, additional, Hendy, Eleanor, additional, Kennedy, Ann, additional, Leeson, Paul, additional, Linsell, Louise, additional, McCarthy, Fergus P, additional, O’Driscoll, Jamie, additional, Placzek, Anna, additional, Poston, Lucilla, additional, Robson, Stephen, additional, Rushby, Pauline, additional, Sandall, Jane, additional, Scholtz, Laura, additional, Seed, Paul T, additional, Sparkes, Jenie, additional, Stanbury, Kayleigh, additional, Tohill, Sue, additional, Thilaganathan, Basky, additional, Townend, John, additional, Juszczak, Edmund, additional, Marlow, Neil, additional, and Shennan, Andrew, additional

Published
2022
Full Text
View/download PDF

16. ROB-MEN: a tool to assess risk of bias due to missing evidence in network meta-analysis

Author

Chiocchia, Virginia, Nikolakopoulou, Adriani, Higgins, Julian P T, Page, Matthew J, Papakonstantinou, Theodoros, Cipriani, Andrea, Furukawa, Toshi A, Siontis, George C.M., Egger, Matthias, Salanti, Georgia, Centre for Infectious Disease Epidemiology and Research (CIDER), and Faculty of Health Sciences

Subjects
Adult, Depressive Disorder, Major, 360 Soziale Probleme, Sozialdienste, 610 Medicine & health, Guideline, Publication bias, Risk Assessment, Risk of bias, 360 Social problems & social services, Evidence synthesis, Selective outcome reporting, Reporting bias, Humans, Medicine, Missing evidence, 610 Medizin und Gesundheit, Network meta-analysis
Abstract

Background Selective outcome reporting and publication bias threaten the validity of systematic reviews and meta-analyses and can affect clinical decision-making. A rigorous method to evaluate the impact of this bias on the results of network meta-analyses of interventions is lacking. We present a tool to assess the Risk Of Bias due to Missing Evidence in Network meta-analysis (ROB-MEN). Methods ROB-MEN first evaluates the risk of bias due to missing evidence for each of the possible pairwise comparison that can be made between the interventions in the network. This step considers possible bias due to the presence of studies with unavailable results (within-study assessment of bias) and the potential for unpublished studies (across-study assessment of bias). The second step combines the judgements about the risk of bias due to missing evidence in pairwise comparisons with (i) the contribution of direct comparisons to the network meta-analysis estimates, (ii) possible small-study effects evaluated by network meta-regression, and (iii) any bias from unobserved comparisons. Then, a level of “low risk”, “some concerns”, or “high risk” for the bias due to missing evidence is assigned to each estimate, which is our tool’s final output. Results We describe the methodology of ROB-MEN step-by-step using an illustrative example from a published NMA of non-diagnostic modalities for the detection of coronary artery disease in patients with low risk acute coronary syndrome. We also report a full application of the tool on a larger and more complex published network of 18 drugs from head-to-head studies for the acute treatment of adults with major depressive disorder. Conclusions ROB-MEN is the first tool for evaluating the risk of bias due to missing evidence in network meta-analysis and applies to networks of all sizes and geometry. The use of ROB-MEN is facilitated by an R Shiny web application that produces the Pairwise Comparisons and ROB-MEN Table and is incorporated in the reporting bias domain of the CINeMA framework and software.

Published
2021

22. Additional file 6 of ROB-MEN: a tool to assess risk of bias due to missing evidence in network meta-analysis

Author

Chiocchia, Virginia, Nikolakopoulou, Adriani, Higgins, Julian P. T., Page, Matthew J., Papakonstantinou, Theodoros, Cipriani, Andrea, Furukawa, Toshi A., Siontis, George C. M., Egger, Matthias, and Salanti, Georgia

Abstract

Additional file 6. Contribution matrix for the network of non-invasive diagnostic modalities for coronary artery disease in patients with low risk acute coronary syndrome.

Published
2021
Full Text
View/download PDF

23. Additional file 3 of ROB-MEN: a tool to assess risk of bias due to missing evidence in network meta-analysis

Author

Chiocchia, Virginia, Nikolakopoulou, Adriani, Higgins, Julian P. T., Page, Matthew J., Papakonstantinou, Theodoros, Cipriani, Andrea, Furukawa, Toshi A., Siontis, George C. M., Egger, Matthias, and Salanti, Georgia

Subjects
ComputingMilieux_GENERAL, ComputingMilieux_THECOMPUTINGPROFESSION, Data_FILES, ComputerSystemsOrganization_PROCESSORARCHITECTURES, Hardware_REGISTER-TRANSFER-LEVELIMPLEMENTATION
Abstract

Additional file 3. Instructions for filling in the ROB-MEN Table.

Published
2021
Full Text
View/download PDF

24. Additional file 4 of ROB-MEN: a tool to assess risk of bias due to missing evidence in network meta-analysis

Author

Chiocchia, Virginia, Nikolakopoulou, Adriani, Higgins, Julian P. T., Page, Matthew J., Papakonstantinou, Theodoros, Cipriani, Andrea, Furukawa, Toshi A., Siontis, George C. M., Egger, Matthias, and Salanti, Georgia

Subjects
psychological phenomena and processes
Abstract

Additional file 4. Description of the judgements from the across-study assessment of bias for the example of non-invasive diagnostic modalities for detection of coronary artery disease in patients with low risk acute coronary syndromes.

Published
2021
Full Text
View/download PDF

26. Additional file 5 of ROB-MEN: a tool to assess risk of bias due to missing evidence in network meta-analysis

Author

Chiocchia, Virginia, Nikolakopoulou, Adriani, Higgins, Julian P. T., Page, Matthew J., Papakonstantinou, Theodoros, Cipriani, Andrea, Furukawa, Toshi A., Siontis, George C. M., Egger, Matthias, and Salanti, Georgia

Abstract

Additional file 5. Flow chart for assessing overall risk of bias due to missing evidence in pairwise comparisons.

Published
2021
Full Text
View/download PDF

27. Additional file 1 of ROB-MEN: a tool to assess risk of bias due to missing evidence in network meta-analysis

Author

Chiocchia, Virginia, Nikolakopoulou, Adriani, Higgins, Julian P. T., Page, Matthew J., Papakonstantinou, Theodoros, Cipriani, Andrea, Furukawa, Toshi A., Siontis, George C. M., Egger, Matthias, and Salanti, Georgia

Abstract

Additional file 1. Network graph, methods and forest plot for the network meta-analysis of non-invasive diagnostic modalities for the detection of coronary artery disease in patients with low risk acute coronary syndromes.

Published
2021
Full Text
View/download PDF

28. Additional file 2 of ROB-MEN: a tool to assess risk of bias due to missing evidence in network meta-analysis

Author

Chiocchia, Virginia, Nikolakopoulou, Adriani, Higgins, Julian P. T., Page, Matthew J., Papakonstantinou, Theodoros, Cipriani, Andrea, Furukawa, Toshi A., Siontis, George C. M., Egger, Matthias, and Salanti, Georgia

Subjects
ComputingMethodologies_PATTERNRECOGNITION, TheoryofComputation_ANALYSISOFALGORITHMSANDPROBLEMCOMPLEXITY, Data_FILES, Hardware_CONTROLSTRUCTURESANDMICROPROGRAMMING, MathematicsofComputing_DISCRETEMATHEMATICS
Abstract

Additional file 2. Instructions for filling in the Pairwise Comparisons Table.

Published
2021
Full Text
View/download PDF

31. Additional file 1 of Study protocol: NeoCLEAR: Neonatal Champagne Lumbar punctures Every time – An RCT: a multicentre, randomised controlled 2 × 2 factorial trial to investigate techniques to increase lumbar puncture success

Author

Marshall, Andrew S. J., Sadarangani, Manish, Scrivens, Alexandra, Williams, Rachel, Yong, Jean, Bowler, Ursula, Linsell, Louise, Chiocchia, Virginia, Bell, Jennifer L., Caz Stokes, Santhanadass, Patricia, Adams, Eleri, Juszczak, Edmund, and Roehr, Charles C.

Abstract

Additional file 1. Supplementary appendix: List of tested and untested outcomes.

Published
2020
Full Text
View/download PDF

32. Study protocol: NeoCLEAR: Neonatal Champagne Lumbar punctures Every time – An RCT: a multicentre, randomised controlled 2 × 2 factorial trial to investigate techniques to increase lumbar puncture success

Author

Marshall, Andrew S J, Sadarangani, Manish, Scrivens, Alexandra, Williams, Rachel, Yong, Jean, Bowler, Ursula, Linsell, Louise, Chiocchia, Virginia, Bell, Jennifer L, Stokes, Caz, Santhanadass, Patricia, Adams, Eleri, Juszczak, Edmund, and Roehr, Charles C

Abstract

Background: The neonatal period carries the highest risk of bacterial meningitis (~ 1 in 5000 births), bearing high mortality (~ 10%) and morbidity (20–50%) rates. Lumbar puncture (LP) remains essential to the diagnosis of meningitis. Though LP is a common procedure in neonates, success rates are lower (50–60%) than in other patient populations. None of the currently-practised neonatal LP techniques are supported by evidence from adequately-powered, randomised controlled trials (RCTs). NeoCLEAR aims to compare two modifications to the traditional technique which are free, accessible, and commonly practised: sitting (as opposed to lying) position, and ‘early’ (as opposed to ‘late’) stylet removal. Methods/design Written parental informed consent permitting, infants in neonatal/maternity wards, of 27⁺ ⁰ to 44⁺ ⁰ weeks corrected gestational age and weighing ≥1000 g, who require an LP, will be randomly allocated to sitting or lying position, and to early or late stylet removal. The co-primary objectives are to compare success rates (the proportion of infants with cerebrospinal fluid red cell count < 10,000/mm³ on first LP procedure) in 1020 infants between the two positions, and between the two methods of stylet removal. Secondary outcomes relate to LP procedures, complications, diagnoses of meningitis, duration of antibiotics and hospital stay. A modified intention-to-treat analysis will be conducted. Discussion Two modifications to the traditional LP technique (sitting vs lying position; and early vs late stylet removal) will be simultaneously investigated in an efficient and appropriately-powered 2 × 2 factorial RCT design. Analysis will identify the optimal techniques (in terms of obtaining easily-interpretable cerebrospinal fluid), as well as the impact on infants, parents and healthcare systems whilst providing robust safety data. Using a pragmatic RCT design, all practitioners will be trained in all LP techniques, but there will inevitably be variation between unit practice guidelines and other aspects of individual care. An improved LP technique would result in: • Fewer uninterpretable samples, repeated attempts and procedures • Reduced distress for infants and families • Decreased antibiotic use and risk of antibiotic resistance • Reduced healthcare costs due to fewer procedures, reduced length of stay, shorter antibiotic courses, and minimised antibiotic-associated complications Trial registration ISRCTN14040914. Date assigned: 26/06/2018.

Published
2020
Full Text
View/download PDF

34. Oxygenated versus standard cold perfusion preservation in kidney transplantation (COMPARE): a randomised, double-blind, paired, phase 3 trial

Author

Jochmans, Ina, primary, Brat, Aukje, additional, Davies, Lucy, additional, Hofker, H Sijbrand, additional, van de Leemkolk, Fenna E M, additional, Leuvenink, Henri G D, additional, Knight, Simon R, additional, Pirenne, Jacques, additional, Ploeg, Rutger J, additional, Abramowicz, Daniel, additional, Banga, Neal, additional, Bemelman, Frederike J, additional, Betjes, Michiel GH, additional, Burns, Richéal, additional, Chiocchia, Virginia, additional, Christiaans, Maarten HL, additional, Darius, Tom, additional, de Jonge, Jeroen, additional, de Vries, Aiko PJ, additional, Detry, Olivier, additional, Hilbrands, Luuk B, additional, Hoksbergen, Arjan WJ, additional, Huurman, Volkert AL, additional, Idu, Mirza M, additional, Jacobs-Tulleneers-Thevissen, Daniel, additional, Jochmans, Ina, additional, Kaisar, Maria, additional, Kanaan, Nada, additional, Kimenai, Diederik, additional, Kuypers, Dirk, additional, Le Moine, Alain, additional, Marshall, Carl, additional, Meurisse, Nicolas, additional, Mikhalski, Dimitri, additional, Moers, Cyril, additional, Monbaliu, Diethard, additional, Nijboer, Willemijn N, additional, Nurmohamed, S Azam, additional, O'Callaghan, John, additional, Papalois, Vassilios, additional, Pipeleers, Lissa, additional, Poyck, Paul PC, additional, Quiroga, Isabel, additional, Randon, Caren, additional, Schurink, Geert W, additional, Seelen, Marc, additional, Szabo, Laszlo, additional, Toorop, Raechel J, additional, van de Poll, Marcel CG, additional, van der Jagt, Michel FP, additional, Van Laecke, Steven, additional, van Zuilen, Arjan D, additional, Weekers, Laurent, additional, and Ysebaert, Dirk, additional

Published
2020
Full Text
View/download PDF

37. Intravenous co-amoxiclav to prevent infection after operative vaginal delivery: the ANODE RCT

Author

Knight, Marian, primary, Chiocchia, Virginia, additional, Partlett, Christopher, additional, Rivero-Arias, Oliver, additional, Hua, Xinyang, additional, Bowler, Ursula, additional, Gray, James, additional, Gray, Shan, additional, Hinshaw, Kim, additional, Khunda, Aethele, additional, Moore, Philip, additional, Mottram, Linda, additional, Owino, Nelly, additional, Pasupathy, Dharmintra, additional, Sanders, Julia, additional, Sultan, Abdul H, additional, Thakar, Ranee, additional, Tuffnell, Derek, additional, Linsell, Louise, additional, and Juszczak, Edmund, additional

Published
2019
Full Text
View/download PDF

38. Additional file 3: of Planned delivery or expectant management for late preterm pre-eclampsia: study protocol for a randomised controlled trial (PHOENIX trial)

Author

Chappell, Lucy, Green, Marcus, Marlow, Neil, Sandall, Jane, Hunter, Rachael, Robson, Stephen, Bowler, Ursula, Chiocchia, Virginia, Pollyanna Hardy, Juszczak, Edmund, Linsell, Louise, Placzek, Anna, Brocklehurst, Peter, and Shennan, Andrew

Abstract

Statistical analysis plan. (DOCX 187 kb)

Published
2019
Full Text
View/download PDF

40. Additional file 1: of Planned delivery or expectant management for late preterm pre-eclampsia: study protocol for a randomised controlled trial (PHOENIX trial)

Author

Chappell, Lucy, Green, Marcus, Marlow, Neil, Sandall, Jane, Hunter, Rachael, Robson, Stephen, Bowler, Ursula, Chiocchia, Virginia, Pollyanna Hardy, Juszczak, Edmund, Linsell, Louise, Placzek, Anna, Brocklehurst, Peter, and Shennan, Andrew

Subjects
body regions, nervous system, fungi, cardiovascular system, lipids (amino acids, peptides, and proteins)
Abstract

Participant information leaflet. (PDF 1587 kb)

Published
2019
Full Text
View/download PDF

41. Additional file 4: of Planned delivery or expectant management for late preterm pre-eclampsia: study protocol for a randomised controlled trial (PHOENIX trial)

Author

Chappell, Lucy, Green, Marcus, Marlow, Neil, Sandall, Jane, Hunter, Rachael, Robson, Stephen, Bowler, Ursula, Chiocchia, Virginia, Pollyanna Hardy, Juszczak, Edmund, Linsell, Louise, Placzek, Anna, Brocklehurst, Peter, and Shennan, Andrew

Abstract

SPIRIT 2013 Checklist: Recommended items to address in a clinical trial protocol and related documents. (DOC 121 kb)

Published
2019
Full Text
View/download PDF

43. Planned early delivery or expectant management for late preterm pre-eclampsia (PHOENIX): a randomised controlled trial

Author

Chappell, Lucy C, primary, Brocklehurst, Peter, additional, Green, Marcus E, additional, Hunter, Rachael, additional, Hardy, Pollyanna, additional, Juszczak, Edmund, additional, Linsell, Louise, additional, Chiocchia, Virginia, additional, Greenland, Melanie, additional, Placzek, Anna, additional, Townend, John, additional, Marlow, Neil, additional, Sandall, Jane, additional, Shennan, Andrew, additional, Agarwal, Umber, additional, Ahmed, Irshad, additional, Ajay, Bini, additional, Alfirevic, Zarko, additional, Arya, Rita, additional, Bambridge, Gabrielle, additional, Bamfo, Jacqueline, additional, Basak, Sambita, additional, Bowler, Ursula, additional, Cameron, Helen, additional, Churchill, David, additional, Cresswell, Janet, additional, Crosfill, Fiona, additional, Denbow, Mark, additional, Dey, Madhuchanda, additional, Everden, Caroline, additional, Ficquet, Jo, additional, Gajewska-Knapik, Katarzyna, additional, Ganapathy, Ramesh, additional, Garrett, Angela, additional, Girling, Joanna, additional, Gornall, Adam, additional, Harding, Kate, additional, Hendy, Eleanor, additional, Howard, Richard, additional, James, Mark, additional, Johnson, Antoinette, additional, Kemp, Michelle, additional, Khalil, Asma, additional, Khan, Rehan, additional, Khan, Rahila, additional, Knox, Ellen, additional, Margarit, Lavinia, additional, Marsden, Philippa, additional, McIntyre, Karen, additional, Myers, Jenny, additional, Nugent, Justine, additional, Rao, Sanjay, additional, Robinson, Zoey, additional, Robson, Stephen, additional, Rushby, Pauline, additional, Scholz, Laura, additional, Shahin, Mohamed, additional, Sharma, Bhavna, additional, Simpson, Nigel, additional, Singh, Natasha, additional, Sparkes, Jenie, additional, Stone, Sophia, additional, Subair, Seni, additional, Tan, Bee, additional, Thakur, Vidya, additional, Thamban, Sujatha, additional, Thornton, Jim, additional, Tohill, Sue, additional, Tsoi, Elly, additional, Tuffnell, Derek, additional, Waterstone, Mark, additional, Waugh, Jason, additional, Wiesender, Cornelia, additional, and Wu, Pensee, additional

Published
2019
Full Text
View/download PDF

44. Very low-dose dexamethasone to facilitate extubation of preterm babies at risk of bronchopulmonary dysplasia: the MINIDEX feasibility RCT

Author

Yates, Helen, primary, Chiocchia, Virginia, additional, Linsell, Louise, additional, Orsi, Nicolas, additional, Juszczak, Edmund, additional, Johnson, Kathryn, additional, Chetcuti, Philip, additional, Illingworth, Claire, additional, Hardy, Pollyanna, additional, Monk, Vaneesha, additional, Newell, Simon, additional, and Turner, Mark, additional

Published
2019
Full Text
View/download PDF

45. Prophylactic antibiotics in the prevention of infection after operative vaginal delivery (ANODE): a multicentre randomised controlled trial

Author

Knight, Marian, primary, Chiocchia, Virginia, additional, Partlett, Christopher, additional, Rivero-Arias, Oliver, additional, Hua, Xinyang, additional, Hinshaw, Kim, additional, Tuffnell, Derek, additional, Linsell, Louise, additional, Juszczak, Edmund, additional, Knight, Marian, additional, Enderby, Helen, additional, Thakar, Ranee, additional, Sultan, Abdul H, additional, Sanders, Julia, additional, Pasupathy, Dharmintra, additional, Moore, Philip, additional, Gray, James, additional, and Khunda, Aethele, additional

Published
2019
Full Text
View/download PDF

46. Network meta‐analysis results against a fictional treatment of average performance: Treatment effects and ranking metric.

Author

Nikolakopoulou, Adriani, Mavridis, Dimitris, Chiocchia, Virginia, Papakonstantinou, Theodoros, Furukawa, Toshi A., and Salanti, Georgia

Subjects
TREATMENT effectiveness, MENSTRUATION, REGRESSION analysis
Abstract

Background: Network meta‐analysis (NMA) produces complex outputs as many comparisons between interventions are of interest. The estimated relative treatment effects are usually displayed in a forest plot or in a league table and several ranking metrics are calculated and presented. Methods: In this article, we estimate relative treatment effects of each competing treatment against a fictional treatment of average performance using the "deviation from the means" coding that has been used to parametrize categorical covariates in regression models. We then use this alternative parametrization of the NMA model to present a ranking metric (PreTA: Preferable Than Average) interpreted as the probability that a treatment is better than a fictional treatment of average performance. Results: We illustrate the alternative parametrization of the NMA model using two networks of interventions, a network of 18 antidepressants for acute depression and a network of four interventions for heavy menstrual bleeding. We also use these two networks to highlight differences among PreTA and existing ranking metrics. We further examine the agreement between PreTA and existing ranking metrics in 232 networks of interventions and conclude that their agreement depends on the precision with which relative effects are estimated. Conclusions: A forest plot with NMA relative treatment effects using "deviation from means" coding could complement presentation of NMA results in large networks and in absence of an obvious reference treatment. PreTA is a viable alternative to existing probabilistic ranking metrics that naturally incorporates uncertainty. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

47. Methods for Evaluating Medical Tests and Biomarkers

Author

Gopalakrishna, Gowri, Langendam, Miranda, Scholten, Rob, Bossuyt, Patrick, Leeflang, Mariska, Noel-Storr, Anna, Thomas, James, Marshall, Iain, Wallace, Byron, Whiting, Penny, Davenport, Clare, GopalaKrishna, Gowri, de Salis, Isabel, Mallett, Sue, Wolff, Robert, Riley, Richard, Westwood, Marie, Kleinen, Jos, Collins, Gary, Reitsma, Hans, Moons, Karel, Zapf, Antonia, Hoyer, Annika, Kramer, Katharina, Kuss, Oliver, Ensor, J., Deeks, J. J., Martin, E. C., Riley, R. D., Rücker, Gerta, Steinhauser, Susanne, Schumacher, Martin, Ensor, Joie, Snell, Kym, Willis, Brian, Debray, Thomas, Deeks, Jon, di Ruffano, Lavinia Ferrante, Taylor-Phillips, Sian, Hyde, Chris, Taylor, Stuart A., Batnagar, Gauraang, Di Ruffano, Lavinia Ferrante, Seedat, Farah, Clarke, Aileen, Byron, Sarah, Nixon, Frances, Albrow, Rebecca, Walker, Thomas, Deakin, Carla, Zhelev, Zhivko, Hunt, Harriet, Yang, Yaling, Abel, Lucy, Buchanan, James, Fanshawe, Thomas, Shinkins, Bethany, Wynants, Laure, Verbakel, Jan, Van Huffel, Sabine, Timmerman, Dirk, Van Calster, Ben, Zwinderman, Aeliko, Oke, Jason, O’Sullivan, Jack, Perera, Rafael, Nicholson, Brian, Bromley, Hannah L., Roberts, Tracy E., Francis, Adele, Petrie, Denniis, Mann, G. Bruce, Malottki, Kinga, Smith, Holly, Billingham, Lucinda, Sitch, Alice, Gerke, Oke, Holm-Vilstrup, Mie, Segtnan, Eivind Antonsen, Halekoh, Ulrich, Høilund-Carlsen, Poul Flemming, Francq, Bernard G., Dinnes, Jac, Parkes, Julie, Gregory, Walter, Hewison, Jenny, Altman, Doug, Rosenberg, William, Selby, Peter, Asselineau, Julien, Perez, Paul, Paye, Aïssatou, Bessede, Emilie, Proust-Lima, Cécile, Naaktgeboren, Christiana, de Groot, Joris, Rutjes, Anne, Reitsma, Johannes, Ogundimu, Emmanuel, Cook, Jonathan, Le Manach, Yannick, Vergouwe, Yvonne, Pajouheshnia, Romin, Groenwold, Rolf, Moons, Karen, Peelen, Linda, Nieboer, Daan, De Cock, Bavo, Pencina, Micael J., Steyerberg, Ewout W., Cooper, Jennifer, Parsons, Nick, Stinton, Chris, Smith, Steve, Dickens, Andy, Jordan, Rachel, Enocson, Alexandra, Fitzmaurice, David, Adab, Peymane, Boachie, Charles, Vidmar, Gaj, Freeman, Karoline, Connock, Martin, Court, Rachel, Moons, Carl, Harris, Jessica, Mumford, Andrew, Plummer, Zoe, Lee, Kurtis, Reeves, Barnaby, Rogers, Chris, Verheyden, Veerle, Angelini, Gianni D., Murphy, Gavin J., Huddy, Jeremy, Ni, Melody, Good, Katherine, Cooke, Graham, Hanna, George, Ma, Jie, Moons, K. G. M. (Carl), de Groot, Joris A. H., Altman, Doug G., Reitsma, Johannes B., Collins, Gary S., Moons, Karel G. M., Altman, Douglas G., Kamarudin, Adina Najwa, Kolamunnage-Dona, Ruwanthi, Cox, Trevor, Borsci, Simone, Pérez, Teresa, Pardo, M.Carmen, Candela-Toha, Angel, Muriel, Alfonso, Zamora, Javier, Sanghera, Sabina, Mohiuddin, Syed, Martin, Richard, Donovan, Jenny, Coast, Joanna, Seo, Mikyung Kelly, Cairns, John, Mitchell, Elizabeth, Smith, Alison, Wright, Judy, Hall, Peter, Messenger, Michael, Calder, Nicola, Wickramasekera, Nyantara, Vinall-Collier, Karen, Lewington, Andrew, Damen, Johanna, Cairns, David, Hutchinson, Michelle, Sturgeon, Cathie, Mitchel, Liz, Kift, Rebecca, Christakoudi, Sofia, Rungall, Manohursingh, Mobillo, Paula, Montero, Rosa, Tsui, Tjir-Li, Kon, Sui Phin, Tucker, Beatriz, Sacks, Steven, Farmer, Chris, Strom, Terry, Chowdhury, Paramit, Rebollo-Mesa, Irene, Hernandez-Fuentes, Maria, Damen, Johanna A. A. G., Debray, Thomas P. A., Heus, Pauline, Hooft, Lotty, Scholten, Rob J. P. M., Schuit, Ewoud, Tzoulaki, Ioanna, Lassale, Camille M., Siontis, George C. M., Chiocchia, Virginia, Roberts, Corran, Schlüssel, Michael Maia, Gerry, Stephen, Black, James A., van der Schouw, Yvonne T., Peelen, Linda M., Spence, Graeme, McCartney, David, van den Bruel, Ann, Lasserson, Daniel, Hayward, Gail, Vach, Werner, de Jong, Antoinette, Burggraaff, Coreline, Hoekstra, Otto, Zijlstra, Josée, de Vet, Henrica, Graziadio, Sara, Allen, Joy, Johnston, Louise, O’Leary, Rachel, Power, Michael, Johnson, Louise, Waters, Ray, Simpson, John, Fanshawe, Thomas R., Phillips, Peter, Plumb, Andrew, Helbren, Emma, Halligan, Steve, Gale, Alastair, Sekula, Peggy, Sauerbrei, Willi, Forman, Julia R., Dutton, Susan J., Takwoingi, Yemisi, Hensor, Elizabeth M., Nichols, Thomas E., Kempf, Emmanuelle, Porcher, Raphael, de Beyer, Jennifer, Altman, Douglas, Hopewell, Sally, Dennis, John, Shields, Beverley, Jones, Angus, Henley, William, Pearson, Ewan, Hattersley, Andrew, Scheibler, Fueloep, Rummer, Anne, Sturtz, Sibylle, Großelfinger, Robert, Banister, Katie, Ramsay, Craig, Azuara-Blanco, Augusto, Burr, Jennifer, Kumarasamy, Manjula, Bourne, Rupert, Uchegbu, Ijeoma, Murphy, Jennifer, Carter, Alex, Murphy, Jen, Marti, Joachim, Eatock, Julie, Robotham, Julie, Dudareva, Maria, Gilchrist, Mark, Holmes, Alison, Monaghan, Phillip, Lord, Sarah, StJohn, Andrew, Sandberg, Sverre, Cobbaert, Christa, Lennartz, Lieselotte, Verhagen-Kamerbeek, Wilma, Ebert, Christoph, Horvath, Andrea, Jenniskens, Kevin, Peters, Jaime, Grigore, Bogdan, Ukoumunne, Obi, Levis, Brooke, Benedetti, Andrea, Levis, Alexander W., Ioannidis, John P. A., Shrier, Ian, Cuijpers, Pim, Gilbody, Simon, Kloda, Lorie A., McMillan, Dean, Patten, Scott B, Steele, Russell J., Ziegelstein, Roy C, Bombardier, Charles H., Osório, Flavia de Lima, Fann, Jesse R., Gjerdingen, Dwenda, Lamers, Femke, Lotrakul, Manote, Loureiro, Sonia R, Löwe, Bernd, Shaaban, Juwita, Stafford, Lesley, van Weert, Henk C. P. M., Whooley, Mary A., Williams, Linda S., Wittkampf, Karin A., Yeung, Albert S., Thombs, Brett D., Cooper, Chris, Nieto, Tom, Smith, Claire, Tucker, Olga, Dretzke, Janine, Beggs, Andrew, Rai, Nirmala, Bayliss, Sue, Stevens, Simon, Mallet, Sue, Sundar, Sudha, Hall, Emma, Porta, Nuria, Estelles, David Lorente, and de Bono, Johann

Subjects
Faecal Immunochemical Test, Chronic Obstructive Pulmonary Disorder, Circulate Tumour Cell Count, Apply Health Research, Meeting Abstracts, Faecal Immunochemical Test Result
Abstract

unKnown

Published
2017

48. Study protocol: NeoCLEAR: Neonatal Champagne Lumbar punctures Every time - An RCT: a multicentre, randomised controlled 2 × 2 factorial trial to investigate techniques to increase lumbar puncture success.

Author

Marshall, Andrew S. J., Sadarangani, Manish, Scrivens, Alexandra, Williams, Rachel, Yong, Jean, Bowler, Ursula, Linsell, Louise, Chiocchia, Virginia, Bell, Jennifer L., Stokes, Caz, Santhanadass, Patricia, Adams, Eleri, Juszczak, Edmund, Roehr, Charles C., and ‘The NeoCLEAR Collaborative Group’

Subjects
LUMBAR puncture, BACTERIAL meningitis, DRUG resistance in bacteria, MEDICAL care costs, HOSPITAL maternity services, SITTING position
Abstract

Background: The neonatal period carries the highest risk of bacterial meningitis (~ 1 in 5000 births), bearing high mortality (~ 10%) and morbidity (20-50%) rates. Lumbar puncture (LP) remains essential to the diagnosis of meningitis. Though LP is a common procedure in neonates, success rates are lower (50-60%) than in other patient populations. None of the currently-practised neonatal LP techniques are supported by evidence from adequately-powered, randomised controlled trials (RCTs). NeoCLEAR aims to compare two modifications to the traditional technique which are free, accessible, and commonly practised: sitting (as opposed to lying) position, and 'early' (as opposed to 'late') stylet removal.Methods/design: Written parental informed consent permitting, infants in neonatal/maternity wards, of 27+ 0 to 44+ 0 weeks corrected gestational age and weighing ≥1000 g, who require an LP, will be randomly allocated to sitting or lying position, and to early or late stylet removal. The co-primary objectives are to compare success rates (the proportion of infants with cerebrospinal fluid red cell count < 10,000/mm3 on first LP procedure) in 1020 infants between the two positions, and between the two methods of stylet removal. Secondary outcomes relate to LP procedures, complications, diagnoses of meningitis, duration of antibiotics and hospital stay. A modified intention-to-treat analysis will be conducted.Discussion: Two modifications to the traditional LP technique (sitting vs lying position; and early vs late stylet removal) will be simultaneously investigated in an efficient and appropriately-powered 2 × 2 factorial RCT design. Analysis will identify the optimal techniques (in terms of obtaining easily-interpretable cerebrospinal fluid), as well as the impact on infants, parents and healthcare systems whilst providing robust safety data. Using a pragmatic RCT design, all practitioners will be trained in all LP techniques, but there will inevitably be variation between unit practice guidelines and other aspects of individual care. An improved LP technique would result in: • Fewer uninterpretable samples, repeated attempts and procedures • Reduced distress for infants and families • Decreased antibiotic use and risk of antibiotic resistance • Reduced healthcare costs due to fewer procedures, reduced length of stay, shorter antibiotic courses, and minimised antibiotic-associated complications TRIAL REGISTRATION: ISRCTN14040914. Date assigned: 26/06/2018. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

49. A multicentre randomised controlled trial to compare the efficacy of ex-vivo normothermic machine perfusion with static cold storage in human liver transplantation

Author

Nasralla, David, primary, Nasralla, David, additional, Akhtar, Mohammed Zeeshan, additional, Bradley, Ally, additional, Butler, Andrew, additional, Chiocchia, Virginia, additional, Dutton, Susan, additional, García-Valdecasas, Juan Carlos, additional, Imber, Charles, additional, Jassem, Wayel, additional, Knight, Simon, additional, Mergental, Hynek, additional, Paul, Andreas, additional, Pirenne, Jacques, additional, Ploeg, Rutger, additional, Coussios, Constantin C, additional, and Friend, Peter J, additional

Published
2018
Full Text
View/download PDF

50. Does the introduction of prostate multiparametric magnetic resonance imaging into the active surveillance protocol for localized prostate cancer improve patient re-classification?

Author

Bryant, Richard J., primary, Yang, Bob, additional, Philippou, Yiannis, additional, Lam, Karla, additional, Obiakor, Maureen, additional, Ayers, Jennifer, additional, Chiocchia, Virginia, additional, Gleeson, Fergus, additional, MacPherson, Ruth, additional, Verrill, Clare, additional, Sooriakumaran, Prasanna, additional, Hamdy, Freddie C., additional, and Brewster, Simon F., additional

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results