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2. Noncontact Detection of Sleep Apnea Using Radar and Expectation-Maximization Algorithm

Author

Koda, Takato, Okumura, Shigeaki, Taki, Hirofumi, Hamada, Satoshi, Sunadome, Hironobu, Sato, Susumu, Chin, Kazuo, and Sakamoto, Takuya

Subjects
Electrical Engineering and Systems Science - Signal Processing
Abstract

Sleep apnea syndrome requires early diagnosis because this syndrome can lead to a variety of health problems. If sleep apnea events can be detected in a noncontact manner using radar, we can then avoid the discomfort caused by the contact-type sensors that are used in conventional polysomnography. This study proposes a novel radar-based method for accurate detection of sleep apnea events. The proposed method uses the expectation-maximization algorithm to extract the respiratory features that form normal and abnormal breathing patterns, resulting in an adaptive apnea detection capability without any requirement for empirical parameters. We conducted an experimental quantitative evaluation of the proposed method by performing polysomnography and radar measurements simultaneously in five patients with the symptoms of sleep apnea syndrome. Through these experiments, we show that the proposed method can detect the number of apnea and hypopnea events per hour with an error of 4.8 times/hour; this represents an improvement in the accuracy by 1.8 times when compared with the conventional threshold-based method and demonstrates the effectiveness of our proposed method., Comment: 8 pages, 12 figures, 3 tables. This work is going to be submitted to the IEEE for possible publication

Published
2023

3. Sex differences among sleep disordered breathing, obesity, and metabolic comorbidities; the Nagahama study

Author

Matsumoto, Takeshi, Murase, Kimihiko, Tabara, Yasuharu, Minami, Takuma, Kanai, Osamu, Sunadome, Hironobu, Takahashi, Naomi, Hamada, Satoshi, Tanizawa, Kiminobu, Wakamura, Tomoko, Komenami, Naoko, Setoh, Kazuya, Kawaguchi, Takahisa, Morita, Satoshi, Takahashi, Yoshimitsu, Nakayama, Takeo, Sato, Susumu, Hirai, Toyohiro, Matsuda, Fumihiko, and Chin, Kazuo

Published
2025
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6. Pulmonary function and chest CT abnormalities 3 months after discharge from COVID-19, 2020–2021: A nation-wide multicenter prospective cohort study from the Japanese respiratory society

Author

Kamata, Hirofumi, Takamatsu, Kazufumi, Fukunaga, Koichi, Chubachi, Shotaro, Nakagawara, Kensuke, Namkoong, Ho, Terai, Hideki, Tanaka, Katsushi, Sato, Susumu, Hagiwara, Eri, Takei, Reoto, Kondoh, Yasuhiro, Takazono, Takahiro, Hashimoto, Midori, Tasaka, Sadatomo, Ohrui, Takashi, Tanino, Yoshinori, Mineshita, Masamichi, Komase, Yuko, Miyazaki, Kazuhito, Nishikawa, Masanori, Ando, Akira, Kita, Hideo, Ichihara, Eiki, Ohshimo, Shinichiro, Murata, Yoriyuki, Ishida, Masayuki, Kobayashi, Seiichi, Uchida, Takahiro, Tateno, Hiroki, Ikari, Jun, Terashima, Takeshi, Kozu, Yutaka, Tateishi, Tomoya, Shinkai, Masaharu, Sagara, Hironori, To, Yasuo, Ito, Yoko, Yamamoto, Masaki, Yamamoto, Yoshihiro, Kita, Toshiyuki, Ito, Yutaka, Tomii, Keisuke, Fujita, Yukio, Funaki, Yoshihiro, Yatera, Kazuhiro, Yamasue, Mari, Komiya, Kosaku, Kozawa, Satoko, Manabe, Hideaki, Hozumi, Hironao, Horiguchi, Tomoya, Kitajima, Takamasa, Nakano, Yasushi, Nagaoka, Tetsutaro, Hojo, Masayuki, Ebihara, Akinori, Kobayashi, Masayoshi, Takayama, Koji, Jinta, Torahiko, Sawai, Toyomitsu, Fukuda, Yuichi, Kaneko, Takeshi, Chin, Kazuo, Ogura, Takashi, Mukae, Hiroshi, Ishii, Makoto, and Yokoyama, Akihito

Published
2024
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9. Hyperfructosemia in sleep disordered breathing: metabolome analysis of Nagahama study

Author

Nakatsuka, Yoshinari, Murase, Kimihiko, Sonomura, Kazuhiro, Tabara, Yasuharu, Nagasaki, Tadao, Hamada, Satoshi, Matsumoto, Takeshi, Minami, Takuma, Kanai, Osamu, Takeyama, Hirofumi, Sunadome, Hironobu, Takahashi, Naomi, Nakamoto, Isuzu, Tanizawa, Kiminobu, Handa, Tomohiro, Sato, Taka-Aki, Komenami, Naoko, Wakamura, Tomoko, Morita, Satoshi, Takeuchi, Osamu, Nakayama, Takeo, Hirai, Toyohiro, Kamatani, Yoichiro, Matsuda, Fumihiko, and Chin, Kazuo

Published
2023
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12. Acetazolamide for OSA and Central Sleep Apnea A Comprehensive Systematic Review and Meta-Analysis

Author

Schmickl, Christopher N, Landry, Shane A, Orr, Jeremy E, Chin, Kazuo, Murase, Kimihiko, Verbraecken, Johan, Javaheri, Shahrokh, Edwards, Bradley A, Owens, Robert L, and Malhotra, Atul

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Lung, Sleep Research, Acetazolamide, Carbonic Anhydrase Inhibitors, Humans, Sleep Apnea, Central, Sleep Apnea, Obstructive, Treatment Outcome, acetazolamide, apnea-hypopnea index, sleep apnea, Clinical Sciences, Respiratory System, Cardiovascular medicine and haematology, Clinical sciences
Abstract

BackgroundTherapy options for OSA and central sleep apnea (CSA) are limited, thus many patients remain untreated. Clinically, acetazolamide is sometimes used for CSA; however, given overlapping pathophysiologic properties of OSA and CSA, we hypothesized that acetazolamide is equally effective for both types. Prior reviews focused on specific subtypes of sleep apnea, study designs, and languages, thus including few studies (typically ≤3) limiting insights.Research questionHow efficacious is acetazolamide for sleep apnea, and is its effect modified by sleep apnea type or acetazolamide dose?Study design and methodsWe queried MEDLINE, EMBASE, and ClinicalTrials.gov from inception until March 11, 2019. Any study in which adults with OSA/CSA received oral acetazolamide vs no acetazolamide (control) that reported sleep apnea-related outcomes was eligible, independent of study design or language. Two reviewers independently assessed eligibility and abstracted data. Primary outcomes were apnea-hypopnea index (AHI) and oxygen saturation nadir. Quality of evidence (QoE) was rated with the use of Grades of Recommendation Assessment, Development and Evaluation methods.ResultsWe included 28 studies (13 OSA/15 CSA; NSubjects,Acetazolamide = 542; NSubjects,Control = 553) that enabled meta-analyses for 24 outcomes. Acetazolamide doses ranged from 36 to 1000 mg/d and treatment duration from 1 to 90 d (median, 6 d). Overall, acetazolamide vs control lowered the AHI by -0.7 effect sizes (95% CI, -0.83 to -0.58; I2 = 0%; moderate QoE) that corresponded to a reduction of 37.7% (95% CI, -44.7 to -31.3) or 13.8/h (95% CI, -16.3 to -11.4; AHIControl = 36.5/h). The AHI reduction was similar in OSA vs CSA, but significantly greater with higher doses (at least up to 500 mg/d). Furthermore, acetazolamide improved oxygen saturation nadir by +4.4% (95% CI, 2.3 to 6.5; I2 = 63%; no evidence of effect modification; very low QoE) and several secondary outcomes that included sleep quality measures and BP (mostly low QoE).InterpretationShort-term acetazolamide improved both OSA and CSA. Rigorous studies with long-term follow up are warranted to assess Acetazolamide's value for the chronic treatment of patients with sleep apnea.Clinical trial registrationPROSPERO (CRD42019147504).

Published
2020

13. Multimodal Telemonitoring for Weight Reduction in Patients With Sleep Apnea: A Randomized Controlled Trial

Author

Murase, Kimihiko, Minami, Takuma, Hamada, Satoshi, Gozal, David, Takahashi, Naomi, Nakatsuka, Yoshinari, Takeyama, Hirofumi, Tanizawa, Kiminobu, Endo, Daisuke, Akahoshi, Toshiki, Moritsuchi, Yasutaka, Tsuda, Toru, Toyama, Yoshiro, Ohi, Motoharu, Tomita, Yasuhiro, Narui, Koji, Matsuyama, Naho, Ohdaira, Tetsuro, Kasai, Takatoshi, Tsuboi, Tomomasa, Gon, Yasuhiro, Yamashiro, Yoshihiro, Ando, Shinichi, Yoshimine, Hiroyuki, Takata, Yoshifumi, Yoshihisa, Akiomi, Tatsumi, Koichiro, Momomura, Shin-ichi, Kuroda, Tomohiro, Morita, Satoshi, Nakayama, Takeo, Hirai, Toyohiro, and Chin, Kazuo

Published
2022
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15. Sleep Apnea Syndrome (SAS) Clinical Practice Guidelines 2020

Author

Akashiba, Tsuneto, Inoue, Yuichi, Uchimura, Naohisa, Ohi, Motoharu, Kasai, Takatoshi, Kawana, Fusae, Sakurai, Shigeru, Takegami, Misa, Tachikawa, Rho, Tanigawa, Takeshi, Chiba, Shintaro, Chin, Kazuo, Tsuiki, Satoru, Tonogi, Morio, Nakamura, Hiroshi, Nakayama, Takeo, Narui, Koji, Yagi, Tomoko, Yamauchi, Motoo, Yamashiro, Yoshihiro, Yoshida, Masahiro, Oga, Toru, Tomita, Yasuhiro, Hamada, Satoshi, Murase, Kimihiko, Mori, Hiroyuki, Wada, Hiroo, Uchiyama, Makoto, Ogawa, Hiromasa, Sato, Kazumichi, Nakata, Seiichi, Mishima, Kazuo, and Momomura, Shin-Ichi

Published
2022
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25. Aquaporin-3 potentiates allergic airway inflammation in ovalbumin-induced murine asthma.

Author

Ikezoe, Kohei, Oga, Toru, Honda, Tetsuya, Hara-Chikuma, Mariko, Ma, Xiaojun, Tsuruyama, Tatsuaki, Uno, Kazuko, Fuchikami, Jun-Ichi, Tanizawa, Kiminobu, Handa, Tomohiro, Taguchi, Yoshio, Verkman, Alan S, Narumiya, Shuh, Mishima, Michiaki, and Chin, Kazuo

Subjects
Lymph Nodes, Spleen, CD4-Positive T-Lymphocytes, Macrophages, Alveolar, Bronchoalveolar Lavage Fluid, Animals, Mice, Inbred C57BL, Asthma, Pneumonia, Hypersensitivity, Hydrogen Peroxide, Ovalbumin, RNA, Messenger, Chemokines, Cell Count, Cell Membrane Permeability, Gene Expression Regulation, Aquaporin 3, Macrophages, Alveolar, Mice, Inbred C57BL, RNA, Messenger
Abstract

Oxidative stress plays a pivotal role in the pathogenesis of asthma. Aquaporin-3 (AQP3) is a small transmembrane water/glycerol channel that may facilitate the membrane uptake of hydrogen peroxide (H2O2). Here we report that AQP3 potentiates ovalbumin (OVA)-induced murine asthma by mediating both chemokine production from alveolar macrophages and T cell trafficking. AQP3 deficient (AQP3(-/-)) mice exhibited significantly reduced airway inflammation compared to wild-type mice. Adoptive transfer experiments showed reduced airway eosinophilic inflammation in mice receiving OVA-sensitized splenocytes from AQP3(-/-) mice compared with wild-type mice after OVA challenge, consistently with fewer CD4(+) T cells from AQP3(-/-) mice migrating to the lung than from wild-type mice. Additionally, in vivo and vitro experiments indicated that AQP3 induced the production of some chemokines such as CCL24 and CCL22 through regulating the amount of cellular H2O2 in M2 polarized alveolar macrophages. These results imply a critical role of AQP3 in asthma, and AQP3 may be a novel therapeutic target.

Published
2016

28. Cutaneous T-cell-attracting chemokine as a novel biomarker for predicting prognosis of idiopathic pulmonary fibrosis: a prospective observational study

Author

Niwamoto, Takafumi, Handa, Tomohiro, Murase, Yuko, Nakatsuka, Yoshinari, Tanizawa, Kiminobu, Taguchi, Yoshio, Tomioka, Hiromi, Tomii, Keisuke, Kita, Hideo, Uyama, Michihiro, Tsuchiya, Michiko, Emura, Masahito, Kawamura, Tetsuji, Arai, Naoki, Arita, Machiko, Uno, Kazuko, Yoshizawa, Akihiko, Uozumi, Ryuji, Yamaguchi, Izumi, Matsuda, Fumihiko, Chin, Kazuo, and Hirai, Toyohiro

Published
2021
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33. Noncontact Detection of Sleep Apnea Using Radar and Expectation–Maximization Algorithm

Author

Koda, Takato, Okumura, Shigeaki, Taki, Hirofumi, Hamada, Satoshi, Sunadome, Hironobu, Sato, Susumu, Chin, Kazuo, and Sakamoto, Takuya

Abstract

Sleep apnea syndrome (SAS) requires early diagnosis because this syndrome can lead to a variety of health problems. If sleep apnea (SA) events can be detected in a noncontact manner using radar, we can then avoid the discomfort caused by the contact-type sensors that are used in conventional polysomnography (PSG). This study proposes a novel radar-based method for accurate detection of SA events. The proposed method uses the expectation–maximization (EM) algorithm to extract the respiratory features that form normal and abnormal breathing patterns, resulting in an adaptive apnea detection capability without any requirement for empirical parameters. We conducted an experimental quantitative evaluation of the proposed method by performing PSG and radar measurements simultaneously in five patients with the symptoms of SAS. Through these experiments, we show that the proposed method can detect the number of apnea and hypopnea events per hour with an error of 4.8 times/h; this represents an improvement in the accuracy by 1.8 times when compared with the conventional threshold-based method and demonstrates the effectiveness of our proposed method.

Published
2024
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34. 胸膜肺実質線維弾性症を伴う特発性間質性肺炎および二次性間質性肺炎の肺移植症例の臨床的・画像的・病理学的特徴

Author

Ikegami, Naoya, primary, Nakajima, Naoki, additional, Yoshizawa, Akihiko, additional, Handa, Tomohiro, additional, Chen-Yoshikawa, Toyofumi, additional, Kubo, Takeshi, additional, Tanizawa, Kiminobu, additional, Ohsumi, Akihiro, additional, Yamada, Yoshito, additional, Hamaji, Masatsugu, additional, Nakajima, Daisuke, additional, Yutaka, Yojiro, additional, Tanaka, Satona, additional, Watanabe, Kizuku, additional, Nakatsuka, Yoshinari, additional, Murase, Yuko, additional, Nakanishi, Tomoko, additional, Niwamoto, Takafumi, additional, Chin, Kazuo, additional, Date, Hiroshi, additional, and Hirai, Toyohiro, additional

Published
2023
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35. Increased blood eosinophils and airflow obstruction as new-onset asthma predictors in the elderly: The Nagahama study

Author

Nishi, Kenta, primary, Nagasaki, Tadao, additional, Matsumoto, Hisako, additional, Oguma, Tsuyoshi, additional, Terada, Satoru, additional, Nomura, Natsuko, additional, Kogo, Mariko, additional, Tashima, Noriyuki, additional, Sunadome, Hironobu, additional, Murase, Kimihiko, additional, Matsumoto, Takeshi, additional, Kawaguchi, Takahisa, additional, Tabara, Yasuharu, additional, Matsuda, Fumihiko, additional, Sato, Susumu, additional, Chin, Kazuo, additional, and Hirai, Toyohiro, additional

Published
2023
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41. Associations between Sleep-Disordered Breathing and Serum Uric Acid and Their Sex Differences: The Nagahama Study

Author

Sunadome, Hironobu, primary, Murase, Kimihiko, additional, Tabara, Yasuharu, additional, Matsumoto, Takeshi, additional, Minami, Takuma, additional, Kanai, Osamu, additional, Nagasaki, Tadao, additional, Takahashi, Naomi, additional, Hamada, Satoshi, additional, Tanizawa, Kiminobu, additional, Togawa, Jumpei, additional, Uiji, Sayaka, additional, Wakamura, Tomoko, additional, Komenami, Naoko, additional, Setoh, Kazuya, additional, Kawaguchi, Takahisa, additional, Morita, Satoshi, additional, Takahashi, Yoshimitsu, additional, Nakayama, Takeo, additional, Hirai, Toyohiro, additional, Sato, Susumu, additional, Matsuda, Fumihiko, additional, and Chin, Kazuo, additional

Published
2023
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42. Longitudinal Changes and Association of Respiratory Symptoms with Preserved Ratio Impaired Spirometry (PRISm): The Nagahama Study

Author

Kogo, Mariko, primary, Sato, Susumu, additional, Muro, Shigeo, additional, Matsumoto, Hisako, additional, Nomura, Natsuko, additional, Oguma, Tsuyoshi, additional, Sunadome, Hironobu, additional, Nagasaki, Tadao, additional, Murase, Kimihiko, additional, Kawaguchi, Takahisa, additional, Tabara, Yasuharu, additional, Matsuda, Fumihiko, additional, Chin, Kazuo, additional, and Hirai, Toyohiro, additional

Published
2023
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43. The long-term outcome of interstitial lung disease with anti-aminoacyl-tRNA synthetase antibodies

Author

Tanizawa, Kiminobu, Handa, Tomohiro, Nakashima, Ran, Kubo, Takeshi, Hosono, Yuji, Watanabe, Kizuku, Aihara, Kensaku, Ikezoe, Kohei, Sokai, Akihiko, Nakatsuka, Yoshinari, Taguchi, Yoshio, Hatta, Kazuhiro, Noma, Satoshi, Kobashi, Yoichiro, Yoshizawa, Akihiko, Oga, Toru, Hirai, Toyohiro, Chin, Kazuo, Nagai, Sonoko, Izumi, Takateru, Mimori, Tsuneyo, and Mishima, Michiaki

Published
2017
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48. The Japanese Respiratory Society Noninvasive Positive Pressure Ventilation (NPPV) Guidelines (second revised edition)

Author

Akashiba, Tsuneto, Ishikawa, Yuka, Ishihara, Hideki, Imanaka, Hideaki, Ohi, Motoharu, Ochiai, Ryoichi, Kasai, Takatoshi, Kimura, Kentaro, Kondoh, Yasuhiro, Sakurai, Shigeru, Shime, Nobuaki, Suzukawa, Masayuki, Takegami, Misa, Takeda, Shinhiro, Tasaka, Sadatomo, Taniguchi, Hiroyuki, Chohnabayashi, Naohiko, Chin, Kazuo, Tsuboi, Tomomasa, Tomii, Keisuke, Narui, Koji, Hasegawa, Nobuyuki, Hasegawa, Ryuichi, Ujike, Yoshihito, Kubo, Keishi, Hasegawa, Yoshinori, Momomura, Shin-ichi, Yamada, Yoshitsugu, Yoshida, Masahiro, Takekawa, Yukie, Tachikawa, Ryo, Hamada, Satoshi, and Murase, Kimihiko

Published
2017
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