1. Development of tuberculosis treatment decision algorithms in children below 5 years hospitalised with severe acute malnutrition in Zambia and Uganda: a prospective diagnostic cohort study
- Author
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Chabala, C, Roucher, C, Ton Nu Nguyet, MH, Babirekere, E, Inambao, M, Businge, G, Kapula, C, Shankalala, P, Nduna, B, Mulenga, V, Graham, S, Wobudeya, E, Bonnet, M, Marcy, O, Serre, A, Badrichani, A, Razafimanantsoa, M, Poublan, J, Vessière, A, Occelli, E, Beuscart, A, Charpin, A, Habiyambere, G, Mesnier, S, Balestre, E, Koskas, N, D'Elbée, M, Font, H, Lounnas, M, Espérou, H, Couffin-Cadiergues, S, Kuppers, A, Hamze, B, Namulinda, F, Sserunjogi, R, Nassozi, R, Barungi, C, Hellen, A, Doreen, M, Kagoya, E, Aciparu, S, Sophia, C, Ntambi, S, Wasswa, A, Nangozi, J, Hambulo, C, Kapotwe, V, Ngambi, M, Kasakwa, K, Kanyama, M, Chirwa, U, Chifunda, K, Mundundu, G, Zulu, S, Nawakwi, G, Siasulingana, T, Himwaze, DA, Chilonga, J, Chimbini, M, Chilanga, M, Chola, D, Mwango, E, Pumbwe, M, Mwambazi, M, Halende, B, Mumba, W, Mankunshe, E, Silavwe, M, Chakopo, M, Moono, R, Chungu, C, Zimba, K, Kapasa, M, Zyambo, K, Chabala, C, Roucher, C, Ton Nu Nguyet, MH, Babirekere, E, Inambao, M, Businge, G, Kapula, C, Shankalala, P, Nduna, B, Mulenga, V, Graham, S, Wobudeya, E, Bonnet, M, Marcy, O, Serre, A, Badrichani, A, Razafimanantsoa, M, Poublan, J, Vessière, A, Occelli, E, Beuscart, A, Charpin, A, Habiyambere, G, Mesnier, S, Balestre, E, Koskas, N, D'Elbée, M, Font, H, Lounnas, M, Espérou, H, Couffin-Cadiergues, S, Kuppers, A, Hamze, B, Namulinda, F, Sserunjogi, R, Nassozi, R, Barungi, C, Hellen, A, Doreen, M, Kagoya, E, Aciparu, S, Sophia, C, Ntambi, S, Wasswa, A, Nangozi, J, Hambulo, C, Kapotwe, V, Ngambi, M, Kasakwa, K, Kanyama, M, Chirwa, U, Chifunda, K, Mundundu, G, Zulu, S, Nawakwi, G, Siasulingana, T, Himwaze, DA, Chilonga, J, Chimbini, M, Chilanga, M, Chola, D, Mwango, E, Pumbwe, M, Mwambazi, M, Halende, B, Mumba, W, Mankunshe, E, Silavwe, M, Chakopo, M, Moono, R, Chungu, C, Zimba, K, Kapasa, M, and Zyambo, K
- Abstract
Background: In children with severe acute malnutrition (SAM) tuberculosis is common, challenging to diagnose, and often fatal. We developed tuberculosis treatment decision algorithms (TDAs) for children under the age of 5 years with SAM. Methods: In this prospective diagnostic study, we enrolled and followed up children aged <60 months hospitalised with SAM at three tertiary hospitals in Zambia and Uganda from 4 November 2019 to 20 June 2022. We included children aged 2–59 months with SAM as defined by WHO and hospitalised following the WHO clinical criteria. We excluded children with current or history of antituberculosis treatment within the preceding 3 months. They underwent tuberculosis symptom screening, clinical assessment, chest X-ray, abdominal ultrasound, Xpert MTB/RIF Ultra (Ultra) and culture on respiratory and stool samples with 6 months follow-up. Tuberculosis was retrospectively defined using the 2015 standard case definition for childhood tuberculosis. We used logistic regression to develop diagnostic prediction models for a one-step diagnosis and a two-step screening and diagnostic approaches. We derived scores from models using WHO-recommended thresholds for sensitivity and proposed TDAs. This study is registered with ClinicalTrials.gov, NCT04240990. Findings: Of 1906 children hospitalised with SAM during the study period, 1230 were screened, 1152 were eligible and 603 were enrolled. Of the 603 children enrolled–median age 15 (inter-quartile range (IQR): 11–20) months and 65 (11.0%) living with HIV–114 (18.9%) were diagnosed with tuberculosis, including 51 (8.5%) with microbiological confirmation and 104 (17.2%) initiated treatment at a median of 6(IQR: 2–10) days after inclusion. 108 children were retrospectively classified as having tuberculosis resulting in a prevalence of 17.9% (95% confidence intervals (CI): 15.1; 21.2). 75 (69.4%) children with tuberculosis reported cough of any duration, 32 (29.6%) cough ≥2 weeks and 11 (10.2%) tuberculosis c
- Published
- 2024