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12 results on '"Chillon, Maria C."'

1. A Next-Generation Sequencing Strategy for Evaluating the Most Common Genetic Abnormalities in Multiple Myeloma

Author

Jiménez, Cristina, Jara-Acevedo, María, Corchete, Luis A., Castillo, David, Ordóñez, Gonzalo R., Sarasquete, María E., Puig, Noemí, Martínez-López, Joaquín, Prieto-Conde, María I., García-Álvarez, María, Chillón, María C., Balanzategui, Ana, Alcoceba, Miguel, Oriol, Albert, Rosiñol, Laura, Palomera, Luis, Teruel, Ana I., Lahuerta, Juan J., Bladé, Joan, Mateos, María V., Orfão, Alberto, San Miguel, Jesús F., González, Marcos, Gutiérrez, Norma C., and García-Sanz, Ramón

Published
2017
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2. Clinical significance of complex karyotype at diagnosis in pediatric and adult patients with de novo acute promyelocytic leukemia treated with ATRA and chemotherapy

Author

Labrador, Jorge, Luno, Elisa, Vellenga, Edo, Brunet, Salut, Gonzalez-Campose, Jose, Chillon, Maria C., Holowiecka, Aleksandra, Esteve, Jordi, Bergua, Juan, Gonzalez-Sanmiguel, Jose D., Gil, Cristina, Tormo, M., Salamero, Olga, Manso, Felix, Fernandez, Isolda, de laSerna, Javier, Moreno, Maria-Jose, Perez-Encinas, M., Krsnik, Isabel, Ribera, Josep-Maria, Cervera, Jose, Calasanz, Maria J., Boluda, Blanca, Sobas, Marta, Lowenberg, Bob, Sanz, Miguel A., Montesinos, Pau, Palmer, L., Fernandez, Ciarlo, S., Bezares, F., Rojas, F., Longoni, H., Gelemur, M., Fazio, P., Canepa, C., Saba, S., Balladares, G., Negri, P., Giunta, M., Milone, J., Prates, M., Lafalse, D., Sossa, C., Jaramillo, F., Mayer, J., Ramos, F., Martinez, J., de Groot, M. R., Schouten, H. C., Hematology, Guided Treatment in Optimal Selected Cancer Patients (GUTS), Stem Cell Aging Leukemia and Lymphoma (SALL), Interne Geneeskunde, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, and MUMC+: MA Hematologie (9)

Subjects
Male, Cancer Research, complex karyotype, ANTHRACYCLINE MONOCHEMOTHERAPY, medicine.medical_treatment, Abnormal Karyotype, chemotherapy, Gastroenterology, Leukocyte Count, 0302 clinical medicine, Leukemia, Promyelocytic, Acute, Recurrence, Acute promyelocytic leukemia, Antineoplastic Combined Chemotherapy Protocols, PROGNOSTIC-SIGNIFICANCE, Cumulative incidence, ATRA, Child, In Situ Hybridization, Fluorescence, Aged, 80 and over, relapse, PETHEMA, Incidence (epidemiology), ADDITIONAL CHROMOSOME-ABNORMALITIES, Age Factors, Hematology, Middle Aged, Prognosis, ARSENIC TRIOXIDE, FLT3 MUTATIONS, Leukemia, Treatment Outcome, Oncology, Child, Preschool, 030220 oncology & carcinogenesis, Cytogenetic Analysis, Female, Adult, medicine.medical_specialty, CYTOGENETIC CHANGES, Adolescent, Young Adult, 03 medical and health sciences, Internal medicine, Statistical significance, Complex Karyotype, medicine, Humans, Clinical significance, Aged, CONSOLIDATION THERAPY, Chromosome Aberrations, Chemotherapy, business.industry, medicine.disease, RISK-ADAPTED TREATMENT, TRANS-RETINOIC ACID, ATRA, Acute promyelocytic leukemia, chemotherapy, complex karyotype, prognostic, relapse, business, prognostic, 030215 immunology
Abstract

Although additional cytogenetic abnormalities (ACA) do not affect the prognosis of patients with t(15;17) acute promyelocytic leukemia (APL), the role of a complex karyotype (CK) is yet to be clarified. We aimed to investigate the relationship of CK with relapse incidence in 1559 consecutive APL patients enrolled in three consecutive trials. Treatment consisted of AIDA induction followed by risk-adapted consolidation. A CK (CK) was defined as the presence of ≥2 ACA, and a very CK (CK+) as ≥3 ACA. Eighty-nine patients (8%) had a CK, of whom 41 (4%) had CK+. The 5-year cumulative incidence of relapse (CIR) in patients with CK was 18%, and 12% in those with

Published
2019

3. High FOXO3a expression is associated with a poorer prognosis in AML with normal cytogenetics

Author

Santamaría, Carlos M., Chillón, Maria C., García-Sanz, Ramón, Pérez, Cristina, Caballero, María D., Ramos, Fernando, de Coca, Alfonso García, Alonso, José M., Giraldo, Pilar, Bernal, Teresa, Queizán, José A., Rodriguez, Juan N., Fernández-Abellán, Pascual, Bárez, Abelardo, Peñarrubia, María J., Vidriales, María B., Balanzategui, Ana, Sarasquete, María E., Alcoceba, Miguel, Díaz-Mediavilla, Joaquín, San Miguel, Jesús F., and Gonzalez, Marcos

Published
2009
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4. Molecular stratification model for prognosis in cytogenetically normal acute myeloid leukemia

Author

Santamaría, Carlos M., Chillón, María C., García-Sanz, Ramón, Pérez, Cristina, Caballero, María D., Ramos, Fernando, de Coca, Alfonso García, Alonso, José M., Giraldo, Pilar, Bernal, Teresa, Queizán, José A., Rodriguez, Juan N., Fernández-Abellán, Pascual, Bárez, Abelardo, Peñarrubia, María J., Balanzategui, Ana, Vidriales, María B., Sarasquete, María E., Alcoceba, Miguel, Díaz-Mediavilla, Joaquín, San Miguel, Jesús F., and Gonzalez, Marcos

Published
2009
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5. Bisphosphonate-related osteonecrosis of the jaw is associated with polymorphisms of the cytochrome P450 CYP2C8 in multiple myeloma: a genome-wide single nucleotide polymorphism analysis

Author

Sarasquete, Maria E., García-Sanz, Ramon, Marín, Luis, Alcoceba, Miguel, Chillón, Maria C., Balanzategui, Ana, Santamaria, Carlos, Rosiñol, Laura, de la Rubia, Javier, Hernandez, Miguel T., Garcia-Navarro, Inmaculada, Lahuerta, Juan J., González, Marcos, and San Miguel, Jesus F.

Published
2008
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6. ZHX2, CHC1L and RAN Gene Expression Levels Determine Different Prognosis Groups in Multiple Myeloma (MM) Patients.

Author

Armellini, Adriana, primary, Sarasquete, Maria E., primary, Garcia-Sanz, Ramon, primary, Perez, Ricardo Lopez, primary, Balanzategui, Ana, primary, Chillon, Maria C., primary, Hernandez, Jose M., primary, Fuentes, Marta, primary, Lopez, Rosa M., primary, Blade, Joan, primary, Terol, Maria J., primary, Martin, Alejandro, primary, Calvo, Javier Fernandez, primary, Gonzalez, Marcos, primary, and Miguel, J.F. San, primary

Published
2005
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7. Analysis of Both Clonal Functional and Non-Functional Immunoglobulin Heavy Chain (IgH) Rearrangements in Waldenström’s Macroglobulinemia.

Author

Martin-Jimenez, Patricia, primary, Balanzategui, Ana, primary, Ocio, Miguel E., primary, Alcoceba, Miguel, primary, Sarasquete, Maria E., primary, Aguilera, Carmen, primary, Portero, Jose A., primary, Calvo, Javier Fernandez, primary, Frade, Javier Garcia, primary, Chillon, Maria C., primary, Diaz, Guadalupe, primary, Armellini, Adriana, primary, Garcia-Sanz, Ramon, primary, Gonzalez, Marcos, primary, and Miguel, J.F. San, primary

Published
2005
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8. p14arf/p16ink4a and p15ink4b Gene Expression Profile by Real Time Quantitative PCR at Diagnosis Predicts for Clinical Outcome in Multiple Myeloma Patients.

Author

Sarasquete, Maria E., primary, Armellini, Adriana, primary, Garcia-Sanz, Ramon, primary, Perez, Ricardo Lopez, primary, Balanzategui, Ana, primary, Chillon, Maria C., primary, Martin-Jimenez, Patricia, primary, Alcoceba, Miguel, primary, Hernandez, Jose M., primary, Fuentes, Marta, primary, Lopez, Rosa M., primary, Blade, Joan, primary, Terol, Maria J., primary, Martin, Alejandro, primary, Calvo, Javier Fernandez, primary, Gonzalez, Marcos, primary, and Miguel, J.F. J.F. San, primary

Published
2005
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11. Molecular Characterization in Hairy Cell Leukemia (HCL): Rearrangement Analysis of Heavy Chain in Immunoglobulin Genes (IgH).

Author

Martín-Jiménez, Patricia, Alcoceba, Miguel, Sarasquete, Maria E., Balanzategui, Ana, de Castro, David Gonzalez, Chillón, Maria C., Queizán, J.A., Barbón, M., Ortega, F., Peñarrubia, M.J., Borrego, D., Cabezudo, M., Blázquez, Lorena, Armellini, Adriana, Fernández, Carina, García-Sanz, Ramón, González, Marcos, and Miguel, J.F. San

Published
2004
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12. p14arf/p16ink4aand p15ink4bGene Expression Profile by Real Time Quantitative PCR at Diagnosis Predicts for Clinical Outcome in Multiple Myeloma Patients.

Author

Sarasquete, Maria E., Armellini, Adriana, Garcia-Sanz, Ramon, Perez, Ricardo Lopez, Balanzategui, Ana, Chillon, Maria C., Martin-Jimenez, Patricia, Alcoceba, Miguel, Hernandez, Jose M., Fuentes, Marta, Lopez, Rosa M., Blade, Joan, Terol, Maria J., Martin, Alejandro, Calvo, Javier Fernandez, Gonzalez, Marcos, and Miguel, J.F. J.F. San

Abstract

p15and p14/p16tumor suppressor genes, have been reported to be frequently inactivated by various mechanisms in haematological malignancies such us MM. Alterations of these cell cycle inhibitors in MM display a close correlation with the cell cycle and clinical outcome. We have evaluated by real time quantitative RT-PCR (RQ-PCR) the expression of the p14/p16and p15genes in purified bone marrow plasma cells (PBMPC) from MM patients in order to evaluate the possible clinical, biological and prognostic significance of these cell cycle regulators.

Published
2005
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