254 results on '"Childs-Disney, Jessica L."'
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2. Heterobifunctional small molecules to modulate RNA function
3. DNA-encoded library versus RNA-encoded library selection enables design of an oncogenic noncoding RNA inhibitor
4. Targeting RNA with Small Molecules
5. Programming inactive RNA-binding small molecules into bioactive degraders
6. Methods for the study of ribonuclease targeting chimeras (RiboTACs)
7. Targeting RNA structures with small molecules
8. Targeting RNA with small molecules, from RNA structures to precision medicines: IUPHAR review: 40.
9. Transcriptome-Wide, Unbiased Profiling of Ribonuclease Targeting Chimeras.
10. Decreasing the intrinsically disordered protein α-synuclein levels by targeting its structured mRNA with a ribonuclease-targeting chimera
11. Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer
12. Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA
13. Affecting RNA biology genome-wide by binding small molecules and chemically induced proximity
14. Progress toward the development of the small molecule equivalent of small interfering RNA
15. Altering the Cleaving Effector in Chimeric Molecules that Target RNA Enhances Cellular Selectivity
16. Computational Tools for Design of Selective Small Molecules Targeting RNA: From Small Molecule Microarrays to Chemical Similarity Searching
17. The Hairpin Form of r(G4C2)exp in c9ALS/FTD Is Repeat-Associated Non-ATG Translated and a Target for Bioactive Small Molecules
18. Small-molecule Targeted Degradation of RNA
19. A Massively Parallel Selection of Small Molecule-RNA Motif Binding Partners Informs Design of an Antiviral from Sequence
20. Decreasing the intrinsically disordered protein α-synuclein levels by targeting its structured mRNA with a ribonuclease-targeting chimera.
21. Approved Anti-cancer Drugs Target Oncogenic Non-coding RNAs
22. Transcriptome-Wide Studies of RNA-Targeted Small Molecules Provide a Simple and Selective r(CUG)exp Degrader in Myotonic Dystrophy
23. Conformational dynamics of RNA G4C2 and G2C4 repeat expansions causing ALS/FTD using NMR and molecular dynamics studies
24. Fragment-Based Approaches to Identify RNA Binders
25. Correction to “Transcriptome-Wide Mapping of Small-Molecule RNA-Binding Sites in Cells Informs an Isoform-Specific Degrader of QSOX1 mRNA”
26. DNA‐Encoded Libraries and Their Application to RNA.
27. Identifying and validating small molecules interacting with RNA (SMIRNAs)
28. Transcriptome-Wide Studies of RNA-Targeted Small Molecules Provide a Simple and Selective r(CUG)exp Degrader in Myotonic Dystrophy.
29. A blood–brain penetrant RNA-targeted small molecule triggers elimination of r(G 4 C 2 ) exp in c9ALS/FTD via the nuclear RNA exosome
30. Computational Tools for Design of Selective Small Molecules Targeting RNA: From Small Molecule Microarrays to Chemical Similarity Searching
31. Rapid Generation of miRNA Inhibitor Leads by Bioinformatics and Efficient High-Throughput Screening Methods
32. Conformational dynamics of RNA G4C2 and G2C4 repeat expansions causing ALS/FTD using NMR and molecular dynamics studies.
33. Transcriptome-Wide Mapping of Small-Molecule RNA-Binding Sites in Cells Informs an Isoform-Specific Degrader of QSOX1 mRNA
34. A meditation on accelerating the development of small molecule medicines targeting RNA
35. Methods for Identifying Ligands that Target Nucleic Acid Molecules and Nucleic Acid Structural Motifs
36. Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G 4 C 2 ) repeat expansion in vitro and in vivo ALS models
37. Reprogramming of Protein-Targeted Small-Molecule Medicines to RNA by Ribonuclease Recruitment
38. Systematically Studying the Effect of Small Molecules Interacting with RNA in Cellular and Preclinical Models
39. A Druglike Small Molecule that Targets r(CCUG) Repeats in Myotonic Dystrophy Type 2 Facilitates Degradation by RNA Quality Control Pathways
40. A Metabolic Murder Mystery: A Case-Based Experiment for the Undergraduate Biochemistry Laboratory
41. Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer.
42. Gini Coefficients as a Single Value Metric to Define Chemical Probe Selectivity
43. Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing
44. Targeted Degradation of the Oncogenic MicroRNA 17-92 Cluster by Structure-Targeting Ligands
45. How We Think about Targeting RNA with Small Molecules
46. Design of small molecules targeting RNA structure from sequence
47. Small molecule recognition of disease-relevant RNA structures
48. Improvement of RNA secondary structure prediction using RNase H cleavage and randomized oligonucleotides
49. Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G4C2) repeat expansion in vitro and in vivo ALS models.
50. A meditation on accelerating the development of small molecule medicines targeting RNA
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