178 results on '"Chibout, Salah-Dine"'
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2. Role of innovation in pharmaceutical regulation: A proposal for principles to evaluate EU General Pharmaceutical Legislation from the innovator perspective
3. Shared Learnings on the New EMA First-in-Human and Early Clinical Trial Guideline: Proceedings From a DIAlogue Session at DIA Europe 2018
4. Safety differentiation: emerging competitive edge in drug development
5. Mechanistic insights into selective killing of OXPHOS-dependent cancer cells by arctigenin
6. Induction of hemangiosarcoma in mice after chronic treatment with S1P-modulator siponimod and its lack of relevance to rat and human
7. Bile acids in drug induced liver injury: Key players and surrogate markers
8. Determination of liver specific toxicities in rat hepatocytes by high content imaging during 2-week multiple treatment
9. Mapping the epigenome — impact for toxicology
10. Editor’s Highlight: Comparative Renal Safety Assessment of the Hepatitis B Drugs, Adefovir, Tenofovir, Telbivudine and Entecavir in Rats
11. Phenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X Receptors
12. Vascular Origin of Vildagliptin-induced Skin Effects in Cynomolgus Monkeys: Pathomechanistic Role of Peripheral Sympathetic System and Neuropeptide Y
13. VeloceGenomics: An Accelerated in Vivo Drug Discovery Approach to Rapidly Predict the Biologic, Drug-Like Activity of Compounds, Proteins, or Genes
14. Discovery of proteins related to coronary artery disease using industrial-scale proteomics analysis of pooled plasma
15. Identification of Dlk1-Dio3 Imprinted Gene Cluster Noncoding RNAs as Novel Candidate Biomarkers for Liver Tumor Promotion
16. Generation of transducers for fluorescence-based microarrays with enhanced sensitivity and their application for gene expression profiling
17. Regulation of Allergic Responses to Chemicals and Drugs: Possible Roles of Epigenetic Mechanisms
18. Comparative assessment of Hepatitis B anti-viral drugs Telbivudine, Entecavir, Tenofovir and Adefovir on renal function and toxicity in rats: 324
19. The Use of Rat Lens Explant Cultures to Study the Mechanism of Drug-Induced Cataractogenesis
20. TNF-α antagonists differentially induce TGF-β1-dependent resuscitation of dormant-like Mycobacterium tuberculosis
21. Past, present and future of gene expression-tailored therapy for lung cancer
22. Vitamin D3 24-hydroxylase mRNA expression in the skin of calcipotriol-treated psoriatic patients correlates with clinical efficacy
23. Effects of clofibric acid on mRNA expression profiles in primary cultures of rat, mouse and human hepatocytes
24. Pimecrolimus Identifies a Common Genomic Anti-inflammatory Profile, is Clinically Highly Effective in Psoriasis and is Well Tolerated
25. An Intrinsic Antibiotic Mechanism in Wounds and Tissue-Engineered Skin
26. Shared Learnings on the New EMA First-in-Human and Early Clinical Trial Guideline: Proceedings From a DIAlogue Session at DIA Europe 2018
27. Use of Human Skin Equivalent Apligraf for in Vitro Assessment of Cumulative Skin Irritation Potential of Topical Products
28. Shared Learnings on the New EMA First-in-Human and Early Clinical Trial Guideline: Proceedings From a DIAlogue Session at DIA Europe 2018
29. Bile Acid Sequestration by Cholestyramine Mitigates FGFR4 Inhibition-Induced ALT Elevation
30. Learning from approved kinase inhibitors to better inform on the safety risks of specific kinases
31. Inhibition of IL-17A by secukinumab shows no evidence of increased Mycobacterium tuberculosis infections
32. T-cell assays confirm immunogenicity of tungsten-induced erythropoietin aggregates associated with pure red cell aplasia
33. The Utility of Gene Expression Profiling from Tissue Samples to Support Drug Safety Assessments
34. Controlled Mycobacterium tuberculosis infection in mice under treatment with anti-IL-17A or IL-17F antibodies, in contrast to TNFα neutralization
35. Editor’s Highlight: Comparative Renal Safety Assessment of the Hepatitis B Drugs, Adefovir, Tenofovir, Telbivudine and Entecavir in Rats
36. Reciprocal changes in DNA methylation and hydroxymethylation and a broad repressive epigenetic switch characterize FMR1 transcriptional silencing in fragile X syndrome
37. Induction of hemangiosarcoma in mice after chronic treatment with S1P-modulator siponimod and its lack of relevance to rat and human.
38. Comparative Renal Safety Assessment of the Hepatitis B Drugs, Adefovir, Tenofovir, Telbivudine and Entecavir in Rats.
39. Bile acids profiling of rat plasma after treatment with Cyclosporin A
40. Determination of liver specific toxicities in rat hepatocytes by High Content Imaging during 2-week multiple treatment
41. LMX1B Mutations Cause Hereditary FSGS without Extrarenal Involvement
42. Identification of Dlk1-Dio3 Imprinted Gene Cluster Noncoding RNAs as Novel Candidate Biomarkers for Liver Tumor Promotion
43. Protein kinase C inhibition induced steroid hormonal perturbation in rat in vivo
44. Investigative safety science as a competitive advantage for Pharma
45. The Use of Rat Lens Explant Cultures to Study the Mechanism of Drug-Induced Cataractogenesis
46. Investigation of Correlation Among Safety Biomarkers in Serum, Histopathological Examination, and Toxicogenomics
47. Urinary clusterin, cystatin C, β2-microglobulin and total protein as markers to detect drug-induced kidney injury
48. A panel of urinary biomarkers to monitor reversibility of renal injury and a serum marker with improved potential to assess renal function
49. Gene Expression Patterns in Peripheral Blood Correlate with the Extent of Coronary Artery Disease
50. Genome-wide analysis of DNA methylation profiles in a preclinical animal model of non-genotoxic carcinogenesis
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