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Objective: To investigate of the effectiveness of biological adhesives in corneal perforation treatment., Method: Three types of surgical treatment of corneal perforation were performed on albino rabbits. Procedure 1 involved perforation closure using cyanoacrylate adhesive (DERMABOND), Procedure 2 involved a gelatinous glue adhesive, gelatin resorcin and formaldehyde (GRF), and Procedure 3 involved routine perforation repair using 10-0 nylon sutures. The healing status of the wounds was examined by comparing anterior eye photos taken before and after perforation. Pathological changes were also observed., Results: 1) The closure using DERMABOND showed less inflammation in pathological findings, resulting in the best corneal clarity. 2) Pathological findings from the wounds closed using GRF showed early cell necrosis (possibly due to the formaldehyde), resulting in corneal vascularization and minor corneal opacity. 3) The outcome of the suturing procedure depended highly on the surgeon's skills; chronic physical stimulation from the sutures caused corneal vascularization and corneal opacity., Conclusions: The application of biological adhesives is effective in treating corneal perforations, with minimal effect on wound healing, and is recommended as a treatment option for these injuries.