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2. Practical and technical key challenges in head and neck adaptive radiotherapy: The GORTEC point of view

Author

Delaby, Nolwenn, Barateau, Anaïs, Chiavassa, Sophie, Biston, Marie-Claude, Chartier, Philippe, Graulières, Eliane, Guinement, Lucie, Huger, Sandrine, Lacornerie, Thomas, Millardet-Martin, Corinne, Sottiaux, Alain, Caron, Jérôme, Gensanne, David, Pointreau, Yoann, Coutte, Alexandre, Biau, Julian, Serre, Anne-Agathe, Castelli, Joel, Tomsej, Milan, Garcia, Robin, Khamphan, Catherine, and Badey, Aurélien

Published
2023
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4. Monte Carlo simulations of microdosimetry and radiolytic species production at long time post proton irradiation using GATE and Geant4‐DNA.

Author

Fois, Giovanna Rosa, Tran, Hoang Ngoc, Fiegel, Vincent, Blain, Guillaume, Chiavassa, Sophie, Craff, Emeline, Delpon, Grégory, Evin, Manon, Haddad, Ferid, Incerti, Sébastien, Koumeir, Charbel, Métivier, Vincent, Mouchard, Quentin, Poirier, Freddy, Potiron, Vincent, Servagent, Noël, Vandenborre, Johan, and Maigne, Lydia

Subjects
REACTIVE oxygen species, IONIZATION chambers, MONTE Carlo method, DEPTH profiling, RADIOLYSIS, PROTON beams
Abstract

Background: Radiobiological effectiveness of radiation in cancer treatment can be studied at different scales (molecular till organ scale) and different time post irradiation. The production of free radicals and reactive oxygen species during water radiolysis is particularly relevant to understand the fundamental mechanisms playing a role in observed biological outcomes. The development and validation of Monte Carlo tools integrating the simulation of physical, physico‐chemical and chemical stages after radiation is very important to maintain with experiments. Purpose: Therefore, in this study, we propose to validate a new Geant4‐DNA chemistry module through the simulation of water radiolysis and Fricke dosimetry experiments on a proton preclinical beam line. Material and methods: In this study, we used the GATE Monte Carlo simulation platform (version 9.3) to simulate a 67.5 MeV proton beam produced with the ARRONAX isochronous cyclotron (IBA Cyclone 70XP) at conventional dose rate (0.2 Gy/s) to simulate the irradiation of ultra‐pure liquid water samples and Fricke dosimeter. We compared the depth dose profile with measurements performed with a plane parallel Advanced PTW 34045 Markus ionization chamber. Then, a new Geant4‐DNA chemistry application proposed from Geant4 version 11.2 has been used to assess the evolution of HO•${\mathrm{HO}}^ \bullet $, eaq−${\mathrm{e}}_{{\mathrm{aq}}}^ - $, H3O+${{\mathrm{H}}}_3{{\mathrm{O}}}^ + $, H2O2${{\mathrm{H}}}_2{{\mathrm{O}}}_2$, H2${{\mathrm{H}}}_2$, HO2•${\mathrm{HO}}_2^ \bullet $, HO2−,O2•−${\mathrm{HO}}_2^ - ,{\mathrm{\ O}}_2^{ \bullet - }$ and HO−${\mathrm{HO}}^ - $ reactive species along time until 1‐h post‐irradiation. In particular, the effect of oxygen and pH has been investigated through comparisons with experimental measurements of radiolytic yields for H2O2${{\mathrm{H}}}_2{{\mathrm{O}}}_2$ and Fe3+. Results: GATE simulations reproduced, within 4%, the depth dose profile in liquid water. With Geant4‐DNA, we were able to reproduce experimental H2O2${{\mathrm{H}}}_2{{\mathrm{O}}}_2$ radiolytic yields 1‐h post‐irradiation in aerated and deaerated conditions, showing the impact of small changes in oxygen concentrations on species evolution along time. For the Fricke dosimeter, simulated G(Fe3+) is 15.97 ± 0.2 molecules/100 eV which is 11% higher than the measured value (14.4 ± 04 molecules/100 eV). Conclusions: These results aim to be consolidated by new comparisons involving other radiolytic species, such as eaq−${\mathrm{e}}_{{\mathrm{aq}}}^ - $ or ,O2•−$,{\mathrm{\ O}}_2^{ \bullet - }$ to further study the mechanisms underlying the FLASH effect observed at ultra‐high dose rates (UHDR). [ABSTRACT FROM AUTHOR]

Published
2024
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7. First evidence of in vivo effect of FLASH radiotherapy with helium ions in zebrafish embryos

Author

Ghannam, Youssef, primary, Chiavassa, Sophie, additional, Saade, Gaëlle, additional, Koumeir, Charbel, additional, Blain, Guillaume, additional, Delpon, Grégory, additional, Evin, Manon, additional, Haddad, Ferid, additional, Maigne, Lydia, additional, Mouchard, Quentin, additional, Servagent, Noël, additional, Potiron, Vincent, additional, and Supiot, Stéphane, additional

Published
2023
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10. Supplementary Figure 3 from Secretion of Acid Sphingomyelinase and Ceramide by Endothelial Cells Contributes to Radiation-Induced Intestinal Toxicity

Author

Leonetti, Daniela, primary, Estéphan, Hala, primary, Ripoche, Natacha, primary, Dubois, Nolwenn, primary, Aguesse, Audrey, primary, Gouard, Sébastien, primary, Brossard, Lisa, primary, Chiavassa, Sophie, primary, Corre, Isabelle, primary, Pecqueur, Claire, primary, Neunlist, Michel, primary, Hadchity, Elie, primary, Gaugler, Marie-Hélène, primary, Mahé, Maxime M., primary, and Paris, François, primary

Published
2023
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11. Data from Secretion of Acid Sphingomyelinase and Ceramide by Endothelial Cells Contributes to Radiation-Induced Intestinal Toxicity

Author

Leonetti, Daniela, primary, Estéphan, Hala, primary, Ripoche, Natacha, primary, Dubois, Nolwenn, primary, Aguesse, Audrey, primary, Gouard, Sébastien, primary, Brossard, Lisa, primary, Chiavassa, Sophie, primary, Corre, Isabelle, primary, Pecqueur, Claire, primary, Neunlist, Michel, primary, Hadchity, Elie, primary, Gaugler, Marie-Hélène, primary, Mahé, Maxime M., primary, and Paris, François, primary

Published
2023
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12. Supplementary Figure 7 from Secretion of Acid Sphingomyelinase and Ceramide by Endothelial Cells Contributes to Radiation-Induced Intestinal Toxicity

Author

Leonetti, Daniela, primary, Estéphan, Hala, primary, Ripoche, Natacha, primary, Dubois, Nolwenn, primary, Aguesse, Audrey, primary, Gouard, Sébastien, primary, Brossard, Lisa, primary, Chiavassa, Sophie, primary, Corre, Isabelle, primary, Pecqueur, Claire, primary, Neunlist, Michel, primary, Hadchity, Elie, primary, Gaugler, Marie-Hélène, primary, Mahé, Maxime M., primary, and Paris, François, primary

Published
2023
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13. Supplementary Figure 1 from Secretion of Acid Sphingomyelinase and Ceramide by Endothelial Cells Contributes to Radiation-Induced Intestinal Toxicity

Author

Leonetti, Daniela, primary, Estéphan, Hala, primary, Ripoche, Natacha, primary, Dubois, Nolwenn, primary, Aguesse, Audrey, primary, Gouard, Sébastien, primary, Brossard, Lisa, primary, Chiavassa, Sophie, primary, Corre, Isabelle, primary, Pecqueur, Claire, primary, Neunlist, Michel, primary, Hadchity, Elie, primary, Gaugler, Marie-Hélène, primary, Mahé, Maxime M., primary, and Paris, François, primary

Published
2023
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14. Supplementary Figure 2 from Secretion of Acid Sphingomyelinase and Ceramide by Endothelial Cells Contributes to Radiation-Induced Intestinal Toxicity

Author

Leonetti, Daniela, primary, Estéphan, Hala, primary, Ripoche, Natacha, primary, Dubois, Nolwenn, primary, Aguesse, Audrey, primary, Gouard, Sébastien, primary, Brossard, Lisa, primary, Chiavassa, Sophie, primary, Corre, Isabelle, primary, Pecqueur, Claire, primary, Neunlist, Michel, primary, Hadchity, Elie, primary, Gaugler, Marie-Hélène, primary, Mahé, Maxime M., primary, and Paris, François, primary

Published
2023
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15. Supplementary Figure 4 from Secretion of Acid Sphingomyelinase and Ceramide by Endothelial Cells Contributes to Radiation-Induced Intestinal Toxicity

Author

Leonetti, Daniela, primary, Estéphan, Hala, primary, Ripoche, Natacha, primary, Dubois, Nolwenn, primary, Aguesse, Audrey, primary, Gouard, Sébastien, primary, Brossard, Lisa, primary, Chiavassa, Sophie, primary, Corre, Isabelle, primary, Pecqueur, Claire, primary, Neunlist, Michel, primary, Hadchity, Elie, primary, Gaugler, Marie-Hélène, primary, Mahé, Maxime M., primary, and Paris, François, primary

Published
2023
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16. Supplementary Figure 5 from Secretion of Acid Sphingomyelinase and Ceramide by Endothelial Cells Contributes to Radiation-Induced Intestinal Toxicity

Author

Leonetti, Daniela, primary, Estéphan, Hala, primary, Ripoche, Natacha, primary, Dubois, Nolwenn, primary, Aguesse, Audrey, primary, Gouard, Sébastien, primary, Brossard, Lisa, primary, Chiavassa, Sophie, primary, Corre, Isabelle, primary, Pecqueur, Claire, primary, Neunlist, Michel, primary, Hadchity, Elie, primary, Gaugler, Marie-Hélène, primary, Mahé, Maxime M., primary, and Paris, François, primary

Published
2023
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17. Supplementary Figure 6 from Secretion of Acid Sphingomyelinase and Ceramide by Endothelial Cells Contributes to Radiation-Induced Intestinal Toxicity

Author

Leonetti, Daniela, primary, Estéphan, Hala, primary, Ripoche, Natacha, primary, Dubois, Nolwenn, primary, Aguesse, Audrey, primary, Gouard, Sébastien, primary, Brossard, Lisa, primary, Chiavassa, Sophie, primary, Corre, Isabelle, primary, Pecqueur, Claire, primary, Neunlist, Michel, primary, Hadchity, Elie, primary, Gaugler, Marie-Hélène, primary, Mahé, Maxime M., primary, and Paris, François, primary

Published
2023
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18. Ultrahigh-Dose-Rate Proton Irradiation Elicits Reduced Toxicity in Zebrafish Embryos

Author

Saade, Gaëlle, primary, Bogaerts, Eva, additional, Chiavassa, Sophie, additional, Blain, Guillaume, additional, Delpon, Grégory, additional, Evin, Manon, additional, Ghannam, Youssef, additional, Haddad, Ferid, additional, Haustermans, Karin, additional, Koumeir, Charbel, additional, Macaeva, Ellina, additional, Maigne, Lydia, additional, Mouchard, Quentin, additional, Servagent, Noël, additional, Sterpin, Edmond, additional, Supiot, Stéphane, additional, and Potiron, Vincent, additional

Published
2023
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19. Hydrogen Peroxide (H2O2) production in response to multiple beam irradiation of protons at UHDR

Author

Evin, Manon, Fiegel, Vincent, Delpon, Grégory, Mouchard, Quentin, Emeline, Craff, Haddad, Ferid, Koumeir, Charbel, Maigne, Lydia, Métivier, Vincent, Potiron, Vincent, Servagent, Noël, Supiot, Stéphane, Vandenborre, Johan, Blain, Guillaume, Chiavassa, Sophie, Laboratoire de physique subatomique et des technologies associées (SUBATECH), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER, GIP ARRONAX [Nantes], Université de Nantes (UN), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Unité en Sciences Biologiques et Biotechnologies de Nantes (US2B), Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, and FLASHMOD

Subjects
FLASHMOD project, Radiochemistry, FLASH effect mecanisms, [SDV.CAN]Life Sciences [q-bio]/Cancer, External beam therapy, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], [CHIM.RADIO]Chemical Sciences/Radiochemistry
Abstract

International audience

Published
2023

20. Radiolytic ROS production mechanism under proton flash conditions : combination of experimental and simulation investigation

Author

Fiegel, Vincent, Fois, Giovanna Rosa, Blain, Guillaume, Evin, Manon, Mouchard, Quentin, Koumeir, Charbel, Servagent, Noël, Emeline, Craff, Ghalei, Mohammad, Métivier, Vincent, Poirier, Freddy, Potiron, Vincent, Supiot, Stéphane, Haddad, Ferid, Delpon, Grégory, Vandenborre, Johan, Maigne, Lydia, Chiavassa, Sophie, Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER, GIP ARRONAX [Nantes], Université de Nantes (UN), Laboratoire de physique subatomique et des technologies associées (SUBATECH), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Unité en Sciences Biologiques et Biotechnologies de Nantes (US2B), Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Financial support from Inserm Cancer (PCSI FLASHMOD), Karen Kirkby, Marie-Catherine Vozenin, Núria Jornet Sala, Stephanie E. Combs, FLASHMOD, ANR-11-EQPX-0004,ARRONAXPLUS,Nucléaire pour la Santé(2011), ANR-16-IDEX-0007,NExT (I-SITE),NExT (I-SITE)(2016), and ANR-11-LABX-0018,IRON,Radiopharmaceutiques Innovants en Oncologie et Neurologie(2011)

Subjects
radiolytic ros, experimental, [SDV.CAN]Life Sciences [q-bio]/Cancer, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], flash therapy, Ultra-high dose rate, simulation, [CHIM.RADIO]Chemical Sciences/Radiochemistry, proton
Abstract

International audience

Published
2022

21. Pyruvate carboxylation identifies Glioblastoma Stem-like Cells opening new metabolic strategy to prevent tumor recurrence

Author

Renoult, Ophélie, primary, Gratas, Catherine, additional, Joalland, Noémie, additional, Laurent--Blond, Mélanie, additional, Awada, Hala, additional, Bourgeois, Marine, additional, Oliver, Lisa, additional, Chiavassa, Sophie, additional, Croyal, Mikaël, additional, Paris, François, additional, and Pecqueur, Claire, additional

Published
2022
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22. Proton Irradiations at Ultra-High Dose Rate vs. Conventional Dose Rate: Strong Impact on Hydrogen Peroxide Yield

Author

Blain, Guillaume, primary, Vandenborre, Johan, additional, Villoing, Daphnée, additional, Fiegel, Vincent, additional, Fois, Giovanna Rosa, additional, Haddad, Ferid, additional, Koumeir, Charbel, additional, Maigne, Lydia, additional, Métivier, Vincent, additional, Poirier, Freddy, additional, Potiron, Vincent, additional, Supiot, Stéphane, additional, Servagent, Noël, additional, Delpon, Grégory, additional, and Chiavassa, Sophie, additional

Published
2022
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24. Technical note: Proton beam dosimetry at ultra‐high dose rates (FLASH): Evaluation of GAFchromic™ (EBT3, EBT‐XD) and OrthoChromic (OC‐1) film performances

Author

Villoing, Daphnée, primary, Koumeir, Charbel, additional, Bongrand, Arthur, additional, Guertin, Arnaud, additional, Haddad, Ferid, additional, Métivier, Vincent, additional, Poirier, Freddy, additional, Potiron, Vincent, additional, Servagent, Noël, additional, Supiot, Stéphane, additional, Delpon, Grégory, additional, and Chiavassa, Sophie, additional

Published
2022
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25. Réduction de la radiotoxicité par hadronthérapie à ultra-haut débit de dose

Author

Saade, Gaëlle, Chiavassa, Sophie, Koumeir, Charbel, Delpon, Grégory, Evin, Manon, Ghannam, Youssef, Haddad, Ferid, Servagent, Noël, Supiot, Stéphane, Potiron, Vincent, Mouchard, Quentin, Nucléaire pour la Santé - - ARRONAXPLUS2011 - ANR-11-EQPX-0004 - EQPX - VALID, and NExT (I-SITE) - - NExT (I-SITE)2016 - ANR-16-IDEX-0007 - IDEX - VALID

Subjects
[SDV.CAN] Life Sciences [q-bio]/Cancer, ULTRA-HIGH DOSE RATE, RADIOTHERAPY
Published
2022

26. UHDR proton beam vs conventional: hydrogen peroxide as FLASH effect sensor

Author

Blain, Guillaume, Vandenborre, Johan, Villoing, Daphnée, Bongrand, A., Fois, Giovanna Rosa, Guertin, Arnaud, Haddad, Ferid, Hotoiu, Lucian, Labarbe, Rudi, Maigne, Lydia, Métivier, Vincent, Poirier, Freddy, Servagent, Noël, Supiot, Stéphane, Delpon, Grégory, Chiavassa, Sophie, Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER, GIP ARRONAX [Nantes], Université de Nantes (UN), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Ion Beam Applications SA [Louvain-La-Neuve, Belgium], IBA, Unité en Sciences Biologiques et Biotechnologies de Nantes (US2B), Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, Financial support from Inserm Cancer (PCSI FLASHMOD), Marie Dutreix, Karen Kirkby, Andreas Schüller, Marie-Catherine Vozenin, FLASHMOD, ANR-11-EQPX-0004,ARRONAXPLUS,Nucléaire pour la Santé(2011), and ANR-16-IDEX-0007,NExT (I-SITE),NExT (I-SITE)(2016)

Subjects
[SDV.CAN]Life Sciences [q-bio]/Cancer, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], [CHIM.RADIO]Chemical Sciences/Radiochemistry
Abstract

International audience

Published
2021

27. Voluntary Wheel Running Does Not Enhance Radiotherapy Efficiency in a Preclinical Model of Prostate Cancer: The Importance of Physical Activity Modalities?

Author

Dufresne, Suzanne, primary, Richard, Cindy, additional, Dieumegard, Arthur, additional, Orfila, Luz, additional, Delpon, Gregory, additional, Chiavassa, Sophie, additional, Martin, Brice, additional, Rouvière, Laurent, additional, Escoffre, Jean-Michel, additional, Oujagir, Edward, additional, Denis de Senneville, Baudouin, additional, Bouakaz, Ayache, additional, Rioux-Leclercq, Nathalie, additional, Potiron, Vincent, additional, and Rébillard, Amélie, additional

Published
2021
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28. A Monte Carlo Determination of Dose and Range Uncertainties for Preclinical Studies with a Proton Beam

Author

Bongrand, Arthur, primary, Koumeir, Charbel, additional, Villoing, Daphnée, additional, Guertin, Arnaud, additional, Haddad, Ferid, additional, Métivier, Vincent, additional, Poirier, Freddy, additional, Potiron, Vincent, additional, Servagent, Noël, additional, Supiot, Stéphane, additional, Delpon, Grégory, additional, and Chiavassa, Sophie, additional

Published
2021
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29. Secretion of Acid Sphingomyelinase and Ceramide by Endothelial Cells Contributes to Radiation-Induced Intestinal Toxicity

Author

Leonetti, Daniela, primary, Estéphan, Hala, additional, Ripoche, Natacha, additional, Dubois, Nolwenn, additional, Aguesse, Audrey, additional, Gouard, Sébastien, additional, Brossard, Lisa, additional, Chiavassa, Sophie, additional, Corre, Isabelle, additional, Pecqueur, Claire, additional, Neunlist, Michel, additional, Hadchity, Elie, additional, Gaugler, Marie-Hélène, additional, Mahé, Maxime M., additional, and Paris, François, additional

Published
2020
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32. The Injection and Chopper-Based System at Arronax C70XP Cyclotron

Author

Poirier, Freddy, Blain, Guillaume, Bulteau-Harel, Francois, Chiavassa, Sophie, Delpon, Gregory, Durand, Teddy, Fattahi, Massoud, Goiziou, Xavier, Haddad, Ferid, Koumeir, Charbel, Sengar, Atul, Trichet, Herve, Vandenborre, Johan, Cyclotron ARRONAX, GIP, Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), and Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)

Subjects
solenoid, injection, experiment, 04 Operation and Upgrades, [PHYS.PHYS.PHYS-ACC-PH]Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph], cyclotron, simulation, Accelerator Physics
Abstract

The multi-particle cyclotron of the Arronax Public Interest Group (GIP) is used to perform irradiation up to hundreds of µA on various experiments and targets. To support low and high average intensity usage and adapt the beam time structure required for high peak intensity operation and experiments such as pulsed experiments studies, it has been devised a pulsing system in the injection of the cyclotron. This system combines the use of a chopper, low frequency switch, and a control system based on the new extended EPICS network. This paper details the pulsing system adopted at Arronax, updates and results for various intensity experimental studies performed with alpha and proton beams. Updated work on the simulation of the injection is also shown, specifically towards high intensity future irradiation., Proceedings of the 22nd International Conference on Cyclotrons and their Applications, Cyclotrons2019, Cape Town, South Africa

Published
2019
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33. Could exercise training alter radiotherapy efficiency in a murine model of prostate cancer?

Author

Dufresne, Suzanne, Gueritat, Jordan, Chiavassa, Sophie, Noblet, Caroline, Assi, Mohamad, Rannou-Bekono, Françoise, Orfila, Luz, Paris, François, Rébillard, Amélie, Laboratoire Mouvement Sport Santé (M2S), École normale supérieure - Cachan (ENS Cachan)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université de Brest (UBO)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Endothelium Radiobiology and Targeting (CRCINA-ÉQUIPE 14), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Université de Rennes (UR)-École normale supérieure - Rennes (ENS Rennes)-Université de Brest (UBO)-Université de Rennes 2 (UR2)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2019

37. DEMAT: A multi-institutional dosimetry audit of rotational and static intensity-modulated radiotherapy

Author

Lafond, Caroline, primary, Chiavassa, Sophie, additional, Bertaut, Cindy, additional, Boussion, Nicolas, additional, Chapel, Nathalie, additional, Chapron, Lucie, additional, Coste, Frédéric, additional, Crespin, Sylvain, additional, Dy, Gilles, additional, Faye, Papa Abdoulaye, additional, Leleu, Cyril, additional, Bouvier, Jeanne, additional, Madec, Ludovic, additional, Mesgouez, Jérôme, additional, Palisson, Jérémy, additional, Vela, Anthony, additional, and Delpon, Grégory, additional

Published
2016
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44. Ultrahigh-Dose-Rate Proton Irradiation Elicits Reduced Toxicity in Zebrafish Embryos.

Author

Saade G, Bogaerts E, Chiavassa S, Blain G, Delpon G, Evin M, Ghannam Y, Haddad F, Haustermans K, Koumeir C, Macaeva E, Maigne L, Mouchard Q, Servagent N, Sterpin E, Supiot S, and Potiron V

Abstract

Purpose: Recently, ultrahigh-dose-rate radiation therapy (UHDR-RT) has emerged as a promising strategy to increase the benefit/risk ratio of external RT. Extensive work is on the way to characterize the physical and biological parameters that control the so-called "Flash" effect. However, this healthy/tumor differential effect is observable in in vivo models, which thereby drastically limits the amount of work that is achievable in a timely manner., Methods and Materials: In this study, zebrafish embryos were used to compare the effect of UHDR irradiation (8-9 kGy/s) to conventional RT dose rate (0.2 Gy/s) with a 68 MeV proton beam. Viability, body length, spine curvature, and pericardial edema were measured 4 days postirradiation., Results: We show that body length is significantly greater after UHDR-RT compared with conventional RT by 180 µm at 30 Gy and 90 µm at 40 Gy, while pericardial edema is only reduced at 30 Gy. No differences were obtained in terms of survival or spine curvature., Conclusions: Zebrafish embryo length appears as a robust endpoint, and we anticipate that this model will substantially fasten the study of UHDR proton-beam parameters necessary for "Flash.", (© 2022 The Authors.)

Published
2022
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