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21 results on '"Chiarucci, Martina"'

5. Predicting failure of hematopoietic stem cell mobilization before it starts: the predicted poor mobilizer (pPM) score

Author

Olivieri, Jacopo, Attolico, Immacolata, Nuccorini, Roberta, Pascale, Sara Pasquina, Chiarucci, Martina, Poiani, Monica, Corradini, Paolo, Farina, Lucia, Gaidano, Gianluca, Nassi, Luca, Sica, Simona, Piccirillo, Nicola, Pioltelli, Pietro Enrico, Martino, Massimo, Moscato, Tiziana, Pini, Massimo, Zallio, Francesco, Ciceri, Fabio, Marktel, Sarah, Mengarelli, Andrea, Musto, Pellegrino, Capria, Saveria, Merli, Francesco, Codeluppi, Katia, Mele, Giuseppe, Lanza, Francesco, Specchia, Giorgina, Pastore, Domenico, Milone, Giuseppe, Saraceni, Francesco, Di Nardo, Elvira, Perseghin, Paolo, and Olivieri, Attilio

Published
2018
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7. Low-Dose Cyclophosphamide versus Intermediate-High-Dose Cyclophosphamide versus Granulocyte Colony-Stimulating Factor Alone for Stem Cell Mobilization in Multiple Myeloma in the Era of Novel Agents: A Multicenter Retrospective Study

Author

Zannetti, Beatrice Anna, Saraceni, Francesco, Cellini, Claudia, Fabbri, Elisabetta, Monaco, Federica, Guarini, Attilio, Laszlo, Daniele, Martino, Massimo, Olivieri, Attilio, Imola, Manuela, Tosi, Patrizia, Chiarucci, Martina, Zuffa, Eliana, and Lanza, Francesco

Published
2021
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9. Mobilization-Driven Postconsolidation Therapy in Elderly Patients with Acute Myeloid Leukemia: Feasibility and Efficacy of Autologous Stem Cell Transplantation versus Low-Dose Gemtuzumab Ozogamicin

Author

Capelli, Debora, Chiarucci, Martina, Poloni, Antonella, Saraceni, Francesco, Mancini, Giorgia, Trappolini, Silvia, Troiani, Emanuela, Montanari, Mauro, Scortechini, Ilaria, Offidani, Massimo, Rupoli, Serena, Scortechini, Anna Rita, Gini, Guido, Discepoli, Giancarlo, Leoni, Pietro, and Olivieri, Attilio

Published
2014
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11. Response to BNT162b2 Sars-Cov-2 Vaccine in Recipients of Allogeneic Hematopoietic Stem Cell Transplant

Author

Saraceni, Francesco, primary, Fiorentini, Alessandro, additional, Morè, Sonia, additional, Guerzoni, Selene, additional, Puglisi, Bruna, additional, Corvaro, Benedetta, additional, Caucci, Sara, additional, Menzo, Stefano, additional, Costantini, Andrea, additional, Butini, Luca, additional, Viola, Nadia, additional, Scortechini, Ilaria, additional, Mancini, Giorgia, additional, Dubbini, Maria Vittoria, additional, Federici, Irene, additional, Kordasti, Shahram, additional, Offidani, Massimo, additional, Patriarca, Francesca, additional, Battista, Marta Lisa, additional, Chiarucci, Martina, additional, Visani, Giuseppe, additional, Falcioni, Sadia, additional, Galieni, Piero, additional, Natale, Annalisa, additional, Vaddinelli, Doriana, additional, Santarone, Stella, additional, Colasante, Fabrizia, additional, Carella, Angelo Michele, additional, Battipaglia, Giorgia, additional, Pane, Fabrizio, additional, and Olivieri, Attilio, additional

Published
2021
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15. Geriatric Assessment Driven Treatment In 149 AML Elderly Patients

Author

Capelli, Debora, primary, Saraceni, Francesco, additional, Chiarucci, Martina, additional, Poloni, Antonella, additional, Mancini, Giorgia, additional, Trappolini, Silvia, additional, Offidani, Massimo, additional, Rupoli, Serena, additional, Montanari, Mauro, additional, Scortechini, Anna Rita, additional, Gini, Guido, additional, Scortechini, Ilaria, additional, Discepoli, Giancarlo, additional, Leoni, Pietro, additional, and Olivieri, Attilio, additional

Published
2013
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16. Conditioning regimen with BCNU, etoposide, cytarabine and melphalan plus amifostine for outpatient autologous stem cell transplant: feasibility and outcome in 97 patients with lymphoma

Author

Scortechini, Ilaria, primary, Montanari, Mauro, additional, Mancini, Giorgia, additional, Inglese, Elena, additional, Calandrelli, Monica, additional, Chiarucci, Martina, additional, Offidani, Massimo, additional, Capelli, Debora, additional, Gini, Guido, additional, Poloni, Antonella, additional, Mancini, Stefania, additional, Raggetti, Gianmario, additional, Leoni, Pietro, additional, and Olivieri, Attilio, additional

Published
2013
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17. Reversal of poor graft function with iron-chelating therapy after allogeneic transplantation for severe aplastic anemia.

Author

Olivieri, Jacopo, Mancini, Giorgia, Goteri, Gaia, Scortechini, Ilaria, Giantomassi, Federica, Chiarucci, Martina, Leoni, Pietro, and Olivieri, Attilio

Subjects
GRAFT rejection, APLASTIC anemia, HOMOGRAFTS, MORTALITY, CHIMERISM, GRAFT versus host disease
Abstract

The article focuses on a study regarding poor graft function (PGF) reversal in iron-chelating therapy in patients with aplastic anemia following allogeneic transplantation. Topics discussed include high mortality rate of cases with graft failure (GF), distinction of GF and PGF by chimerism analysis, mixing of chimerism in case of rejection, full donor chimerism in case of PGF, factors that lead to GF such as graft-versus-host disease (GVHD), and overload of iron as a reason for PGF.

Published
2016
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18. Efficacy and Feasibility of High-Dose Cytarabine Plus Idarubicin and Amifostine As Induction Schedule: A Prospective Observational Study of 100 AML Elderly Fit Patients

Author

Capelli, Debora, primary, Chiarucci, Martina, additional, Saraceni, Francesco, additional, Poloni, Antonella, additional, Montanari, Mauro, additional, Offidani, Massimo, additional, Rupoli, Serena, additional, Scortechini, Anna Rita, additional, Gini, Guido, additional, Scortechini, Ilaria, additional, Leoni, Pietro, additional, and Olivieri, Attilio, additional

Published
2012
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19. Gemtuzumab-Ozogamicin as Post-Consolidation Therapy In Elderly Patients with Acute Myeloid Leukemia: a Pilot Study

Author

Debora, Capelli, primary, Mancini, Giorgia, additional, Chiarucci, Martina, additional, Saraceni, Francesco, additional, Poloni, Antonella, additional, Trappolini, Silvia, additional, Costantini, Benedetta, additional, Montanari, Mauro, additional, Gini, Guido, additional, Scortechini, Ilaria, additional, Leoni, Pietro, additional, and Olivieri, Attilio, additional

Published
2010
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20. Conditioning regimen with BCNU, etoposide, cytarabine and melphalan plus amifostine for outpatient autologous stem cell transplant: feasibility and outcome in 97 patients with lymphoma.

Author

Scortechini, Ilaria, Montanari, Mauro, Mancini, Giorgia, Inglese, Elena, Calandrelli, Monica, Chiarucci, Martina, Offidani, Massimo, Capelli, Debora, Gini, Guido, Poloni, Antonella, Mancini, Stefania, Raggetti, Gianmario, Leoni, Pietro, and Olivieri, Attilio

Subjects
FEASIBILITY studies, TREATMENT effectiveness, LYMPHOMA treatment, CANCER chemotherapy, AUTOTRANSPLANTATION, STEM cell transplantation, OUTPATIENT medical care, CHEMOTHERAPY complications
Abstract

The article discusses a feasibility study and treatment outcome of a conditioning regimen with BCNU, etoposide, cytarabine and melphalan plus amifostine (BEAMaM) for autologous stem cell transplant (ASCT) outpatients with lymphoma. Topics include a list of inclusion criteria for the study, the experimental design, and a discussion of the study results, such as rehospitalization rates, severe mucositis in individuals receiving BEAM, and quality of life (QOL).

Published
2014
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21. Predicting failure of hematopoietic stem cell mobilization before it starts: the Predicted Poor Mobilizer (pPM) score

Author

Nicola Piccirillo, Paolo Corradini, Domenico Pastore, Roberta Nuccorini, Giorgina Specchia, Francesco Saraceni, Massimo Martino, Massimo Pini, Sarah Marktel, Andrea Mengarelli, Pietro Pioltelli, Giuseppe Milone, Francesco Zallio, Monica Poiani, Elvira Di Nardo, Saveria Capria, Sara Pasquina Pascale, Tiziana Moscato, Gianluca Gaidano, Immacolata Attolico, Pellegrino Musto, Paolo Perseghin, Francesco Merli, Lucia Farina, Luca Nassi, Martina Chiarucci, Simona Sica, Giuseppe Mele, Jacopo Olivieri, Francesco Lanza, Attilio Olivieri, Fabio Ciceri, Katia Codeluppi, Olivieri, Jacopo, Attolico, Immacolata, Nuccorini, Roberta, Pascale, Sara Pasquina, Chiarucci, Martina, Poiani, Monica, Corradini, Paolo, Farina, Lucia, Gaidano, Gianluca, Nassi, Luca, Sica, Simona, Piccirillo, Nicola, Pioltelli, Pietro Enrico, Martino, Massimo, Moscato, Tiziana, Pini, Massimo, Zallio, Francesco, Ciceri, Fabio, Marktel, Sarah, Mengarelli, Andrea, Musto, Pellegrino, Capria, Saveria, Merli, Francesco, Codeluppi, Katia, Mele, Giuseppe, Lanza, Francesco, Specchia, Giorgina, Pastore, Domenico, Milone, Giuseppe, Saraceni, Francesco, Di Nardo, Elvira, Perseghin, Paolo, and Olivieri, Attilio

Subjects
Oncology, Adult, Male, medicine.medical_specialty, Multivariate analysis, Adolescent, lymphoma, Filgrastim, Likelihood ratios in diagnostic testing, NO, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Predictive Value of Tests, Risk Factors, Internal medicine, medicine, Humans, Child, Hematopoietic Stem Cell Mobilization, Aged, Retrospective Studies, Transplantation, Mobilization, Receiver operating characteristic, business.industry, Plerixafor, Patient Selection, Area under the curve, poor mobiliser, Hematology, Middle Aged, stem cell mobilization, lymphoma, myeloma, poor mobiliser, oredicting clinical score, stem cell mobilization, Settore MED/15 - MALATTIE DEL SANGUE, myeloma, oredicting clinical score, 030220 oncology & carcinogenesis, Area Under Curve, Child, Preschool, Female, business, Multiple Myeloma, 030215 immunology, medicine.drug
Abstract

Predicting mobilization failure before it starts may enable patient-tailored strategies. Although consensus criteria for predicted PM (pPM) are available, their predictive performance has never been measured on real data. We retrospectively collected and analyzed 1318 mobilization procedures performed for MM and lymphoma patients in the plerixafor era. In our sample, 180/1318 (13.7%) were PM. The score resulting from published pPM criteria had sufficient performance for predicting PM, as measured by AUC (0.67, 95%CI: 0.63–0.72). We developed a new prediction model from multivariate analysis whose score (pPM-score) resulted in better AUC (0.80, 95%CI: 0.76–0.84, p < 0001). pPM-score included as risk factors: increasing age, diagnosis of NHL, positive bone marrow biopsy or cytopenias before mobilization, previous mobilization failure, priming strategy with G-CSF alone, or without upfront plerixafor. A simplified version of pPM-score was categorized using a cut-off to maximize positive likelihood ratio (15.7, 95%CI: 9.9–24.8); specificity was 98% (95%CI: 97–98.7%), sensitivity 31.7% (95%CI: 24.9–39%); positive predictive value in our sample was 71.3% (95%CI: 60–80.8%). Simplified pPM-score can “rule in” patients at very high risk for PM before starting mobilization, allowing changes in clinical management, such as choice of alternative priming strategies, to avoid highly likely mobilization failure.

Published
2018

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