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Your search keyword '"Chiarella, Sergio E."' showing total 272 results
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272 results on '"Chiarella, Sergio E."'

5. Global disparities in availability of epinephrine auto-injectors

Author

Tanno, Luciana Kase, Worm, Margitta, Ebisawa, Motohiro, Ansotegui, Ignacio J., Senna, Gianenrico, Fineman, Stanley, Geller, Mario, Gonzalez-Estrada, Alexei, Campbell, Dianne E., Leung, Agnes, Muraro, Antonella, Levin, Michael, Ortega Martell, Jose Antonio, Caminati, Marco, Kolkhir, Pavel, Le Pham, Duy, Darlenski, Razvigor, Esteban-Gorgojo, Ignacio, Rial, Manuel, Filipovic, Ivana, Chiarella, Sergio E., Cuervo-Pardo, Lyda, Kwong, Christina, Pozo-Beltran, Cezar Fireth, Trinh, Tu HK., Greenberger, Paul A., Turner, Paul J., Thong, Bernard Yu-Hor, Martin, Bryan, and Cardona, Victoria

Published
2023
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16. Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis

Author

Soberanes, Saul, Misharin, Alexander V., Jairaman, Amit, Morales-Nebreda, Luisa, McQuattie-Pimentel, Alexandra C., Cho, Takugo, Hamanaka, Robert B., Meliton, Angelo Y., Reyfman, Paul A., Walter, James M., Chen, Ching-I, Chi, Monica, Chiu, Stephen, Gonzalez-Gonzalez, Francisco J., Antalek, Matthew, Abdala-Valencia, Hiam, Chiarella, Sergio E., Sun, Kaitlyn A., Woods, Parker S., Ghio, Andrew J., Jain, Manu, Perlman, Harris, Ridge, Karen M., Morimoto, Richard I., Sznajder, Jacob I., Balch, William E., Bhorade, Sangeeta M., Bharat, Ankit, Prakriya, Murali, Chandel, Navdeep S., Mutlu, Gökhan M., and Budinger, G.R. Scott

Published
2019
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21. Paired Indoor and Outdoor Nitrogen Dioxide Associated With Childhood Asthma Outcomes in a Mixed Rural-Urban Setting: A Feasibility Study

Author

Wi, Chung-Il, primary, Gent, Janneane F., additional, Bublitz, Joshua T., additional, King, Katherine S., additional, Ryu, Euijung, additional, Sorrentino, Keli, additional, Plano, Julie, additional, McKay, Lisa, additional, Porcher, Julie, additional, Wheeler, Philip H., additional, Chiarella, Sergio E., additional, DeWan, Andrew T., additional, Godri Pollitt, Krystal J., additional, Sheares, Beverley J., additional, Leaderer, Brian, additional, and Juhn, Young J., additional

Published
2023
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22. Asthma in pregnancy

Author

Bravo-Solarte, Daniela C., primary, Garcia-Guaqueta, Danna P., additional, and Chiarella, Sergio E., additional

Published
2023
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23. Additional file 1 of Biomarkers of cellular senescence in idiopathic pulmonary fibrosis

Author

Aversa, Zaira, Atkinson, Elizabeth J., Carmona, Eva M., White, Thomas A., Heeren, Amanda A., Jachim, Sarah K., Zhang, Xu, Cummings, Steven R., Chiarella, Sergio E., Limper, Andrew H., and LeBrasseur, Nathan K.

Abstract

Additional file 1: Table S1. List of the Proteins Measured in the Plasma of IPF and Control Participants. Table S2. Microarray probes. Table S3. Main Diagnoses Reported by IPF and Control Participants. Table S4. LASSO Regression Analysis to Predict Idiopathic Pulmonary Fibrosis (IPF) Diagnosis. Table S5. Unadjusted and Adjusted (for age, sex, and BMI) Spearman’s Rank Correlations between the Biomarkers and the Forced Vital Capacity (FVC). Table S6. Unadjusted and Adjusted (for age, sex, and BMI) Spearman’s Rank Correlations between the Biomarkers and Diffusing Capacity of the Lung for Carbon Monoxide (DLCO). Table S7. Unadjusted and Adjusted (for age, sex, and BMI) Spearman’s Rank Correlations between the Biomarkers and Forced Expiratory Volume in 1 s (FEV1). Table S8. Unadjusted and Adjusted (for age, sex, and BMI) Spearman’s Rank Correlations between the Biomarkers and St. George Respiratory Questionnaire (SGRQ). Table S9. Unadjusted and Adjusted (for age, sex, and BMI) Spearman’s Rank Correlations between the Biomarkers and 12-Item Short Form Health Survey (SF-12). Table S10. Unadjusted and Adjusted (for age, sex, and BMI) Spearman’s rank Correlations between the Biomarkers and 6-Minute Walk Test (6MWT). Table S11. LASSO Regression Analysis to Predict Forced Vital Capacity (FVC), Diffusing Capacity of the Lung for Carbon Monoxide (DLCO), and Forced Expiratory Volume in 1 s (FEV1). Table S12. LASSO Regression Analysis to Predict St. George Respiratory Questionnaire (SGRQ), 12-Item Short Form Health Survey (SF-12), and the 6-minute walk test (6MWT). Table S13: Associations between Circulating Biomarkers and Risk of Death after adjustment for Age, BMI, and Sex in IPF Participants. Table S14 Unadjusted and Adjusted (for age, sex, and BMI) Spearman’s Rank Correlations between the Circulating Biomarkers and P16 Lung Gene Expression. Table S15. LASSO Regression Analysis to Predict Lung P16 Gene Expression.

Published
2023
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28. -adrenergic agonists augment air pollution-induced IL-6 release and thrombosis

Author

Chiarella, Sergio E., Soberanes, Saul, Urich, Daniela, Morales-Nebreda, Luisa, Nigdelioglu, Recep, Green, David, Young, James B., Gonzalez, Angel, Rosario, Carmen, Misharin, Alexander V., Ghio, Andrew J., Wunderink, Richard G., Donnelly, Helen K., Radigan, Kathryn A., Perlman, Harris, Chandel, Navdeep S., Budinger, G.R. Scott, and Mutlu, Gokhan M.

Subjects
Interleukin-6 -- Properties, Physiological research, Immune response -- Research, Particles -- Properties, Catecholamines -- Identification and classification, Health care industry
Abstract

Acute exposure to particulate matter (PM) air pollution causes thrombotic cardiovascular events, leading to increased mortality rates; however, the link between PM and cardiovascular dysfunction is not completely understood. We have previously shown that the release of IL-6 from alveolar macrophages is required for a prothrombotic state and acceleration of thrombosis following exposure to PM. Here, we determined that PM exposure results in the systemic release of catecholamines, which engage the [β.sub.2]-adrenergic receptor ([β.sub.2]AR) on murine alveolar macrophages and augment the release of IL-6. In mice, [β.sub.2]AR signaling promoted the development of a prothrombotic state that was sufficient to accelerate arterial thrombosis. In primary human alveolar macrophages, administration of a [β.sub.2]AR agonist augmented IL-6 release, while the addition of a beta blocker inhibited PM-induced IL-6 release. Genetic loss or pharmacologic inhibition of the [β.sub.2]AR on murine alveolar macrophages attenuated PM-induced IL-6 release and prothrombotic state. Furthermore, exogenous [β.sub.2]AR agonist therapy further augmented these responses in alveolar macrophages through generation of mitochondrial ROS and subsequent increase of adenylyl cyclase activity. Together, these results link the activation of the sympathetic nervous system by [β.sub.2]AR signaling with metabolism, lung inflammation, and an enhanced susceptibility to thrombotic cardiovascular events., Introduction Based on air pollution exposure estimates in the US from the late 1970s to the early 2000s, Pope et al. projected that a 10 µg/[m.sup.3] fall in the mean [...]

Published
2014
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34. Senolytics reduce coronavirus-related mortality in old mice

Author

Camell, Christina D., primary, Yousefzadeh, Matthew J., additional, Zhu, Yi, additional, Prata, Larissa G. P. Langhi, additional, Huggins, Matthew A., additional, Pierson, Mark, additional, Zhang, Lei, additional, O’Kelly, Ryan D., additional, Pirtskhalava, Tamar, additional, Xun, Pengcheng, additional, Ejima, Keisuke, additional, Xue, Ailing, additional, Tripathi, Utkarsh, additional, Espindola-Netto, Jair Machado, additional, Giorgadze, Nino, additional, Atkinson, Elizabeth J., additional, Inman, Christina L., additional, Johnson, Kurt O., additional, Cholensky, Stephanie H., additional, Carlson, Timothy W., additional, LeBrasseur, Nathan K., additional, Khosla, Sundeep, additional, O’Sullivan, M. Gerard, additional, Allison, David B., additional, Jameson, Stephen C., additional, Meves, Alexander, additional, Li, Ming, additional, Prakash, Y. S., additional, Chiarella, Sergio E., additional, Hamilton, Sara E., additional, Tchkonia, Tamara, additional, Niedernhofer, Laura J., additional, Kirkland, James L., additional, and Robbins, Paul D., additional

Published
2021
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