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Introduction Patients with cardiac amyloidosis (CA) frequently present with heart failure with various extra-cardiac red flags. However, some patients can present with typical or atypical chest pain or even mimicking an acute coronary syndrome. Significant epicardial coronary artery disease (CAD) and CA can coexist, but microvascular dysfunction might also play a role. The aims of this study were to systematically investigate clinical indications for invasive coronary angiography (ICA) in patients with CA, to verify the prevalence of significant epicardial CAD and its relation to the symptoms at presentation, and to start investigating the role cardiac troponin (cTn) in this setting of patients with multiple possible causes of myocardial injury. Methods Retrospective observational study of patients with CA, both transthyretin (ATTR-CA) and light chain (AL-CA) evaluated in our Cardiac Amyloidosis Outpatient Clinic and undergoing ICA for clinical indication. Significant epicardial CAD was defined as stenosis ≥ 50% of the left main coronary artery and/or ≥ 70% of the other epicardial vessels. Results Of the 161 patients initially evaluated, 67 (42%) underwent ICA; after exclusion of those with ICA older than 5 years than CA diagnosis, the final cohort was of 61 patients, 12 (20%) AL-CA and 49 (80%) ATTR-CA. Patients with significant epicardial CAD at the index ICA had ATTR-CA and were more frequently affected by systemic hypertension and dyslipidemia. In 42 (69%) patients ICA was performed during an urgent hospitalization and in 38 (62%) patients CA diagnosis was already established/suspected at the time of the index ICA. The most common indication for ICA was chest pain (n=24, 39%), followed by dyspnea (n=21, 34%); electrocardiographic alterations/arrhythmias were the main indication for 4 patients (6.6%) while imaging for 6 (9.8%). In the remaining 6 patients (9.8%), there were other indications. Prevalence of significant epicardial CAD at the index ICA was 28% (n=17), up to 36% (n=22) if patients with previous coronary revascularization but without actual critical stenoses at index ICA were included. Among those presenting with chest pain (n=24), 9 (38%) had significant epicardial CAD at the index ICA whereas 15 (62%) did not. Considering those presenting with an acute event, the most frequent indication for ICA was chest pain (n=20, 48%); among these patients with chest pain, 55% did not have evidence of significant epicardial CAD whilst 45% did. Regarding cardiac troponin (cTn) values, concentrations at all timepoints were similar between patients with and without significant epicardial CAD at index ICA, also considering those presenting acutely and for chest pain. Conclusion In our cohort of CA patients undergoing ICA, the main clinical indication was chest pain; however, the majority of those presenting with chest pain did not have evidence of significant epicardial CAD. Significant epicardial CAD was present in around one third of patient, which is slightly less than what reported in non-amyloidotic HFpEF patients. The role of cTn in this setting is controversial, due to the possible concomitant causes of chronic and acute myocardial injury in these patients.

Rituximab (RTX) is widely employed to treat Epstein-Barr virus reactivation in children undergoing Hematopoietic Cell Transplantation (HCT). The resulting loss of B cells may cause persistent hypogammaglobulinemia. This retrospective cross-sectional study aims to identify flow cytometry biomarkers associated with persistent hypogammaglobulinemia in patients receiving RTX after HCT. We analyzed 5 patients (cases group) requiring immunoglobulin substitution due to low level of IgG (IgG5 g/L) detected after RTX treatment and 5 patients (controls group) not requiring long-term immunoglobulin (Ig) substitution. We investigated the B cell reconstitution, and in patients group we observed a significantly lower count in B total, IgD+CD27+ marginal B cells and IgD-CD27+ switched-memory B cells, after a median of 5 years from HCT, compared with the control group. Despite the importance limits of our study and the heterogeneity of our data (age of included patients, time of evaluation, interval between RTX dose and assessment) we conclude that RTX given early after HCT might cause a deranged B cell maturation, contributing to the delation in B cell recovery following HCT, and switched memory and marginal zone B cell counts could be a promising biomarker to identify patients requiring long-term Ig substitution.

Summary Background Presenting symptoms of childhood cancers might mimic those of rheumatic diseases. However, the evidence available to guide differential diagnosis remains scarce. Preventing wrong or delayed diagnosis is therefore important to avoid incorrect administration of glucocorticoid or immunosuppressive therapy and worsening of prognosis. As such, we aimed to assess the prevalence and characteristics of presenting musculoskeletal manifestations in patients at cancer onset and to identify the factors that differentiate childhood malignancies with arthropathy from juvenile idiopathic arthritis. Methods We did a multicentre, cross-sectional study at 25 paediatric haemato-oncology centres and 22 paediatric rheumatology centres in Italy. We prospectively recruited patients who were younger than 16 years that were newly diagnosed with cancer or juvenile idiopathic arthritis. We excluded patients with glucocorticoid pre-treatment (>1 mg/kg per day of oral prednisone or equivalent for ≥2 consecutive weeks). We collected data for patients with a new diagnosis of cancer or juvenile idiopathic arthritis using an electronic case report form on a web-based platform powered by the Cineca Interuniversity Consortium. The primary outcome was to describe the frequency and characteristics of musculoskeletal manifestations at cancer onset; and the secondary outcome was to identify factors that could discriminate malignancies presenting with arthropathy, with or without other musculoskeletal symptoms, from juvenile idiopathic arthritis using multivariable logistic regression analysis. Findings Between May 1, 2015, and May 31, 2018, 1957 patients were eligible, of which 1277 (65%) had cancer and 680 (35%) had juvenile idiopathic arthritis. Musculoskeletal symptoms occurred in 324 (25% [95% CI 23·0–27·8]) of 1277 patients with cancer, of whom 207 had arthropathy. Patients with malignant bone tumours had the highest frequency of musculoskeletal symptoms (53 [80%] of 66), followed by patients with Langerhans histiocytosis (16 [47%] of 34), leukaemia (189 [32%] of 582), soft-tissue sarcomas (16 [24%] of 68), and neuroblastoma (21 [19%] of 109). In the 324 patients with cancer and musculoskeletal symptoms, the most common complaints were joint pain (199 [61%]), followed by limb bone pain (112 [35%]). Joint involvement had a prevalent monoarticular pattern (100 [48%] of 207) and oligoarticular pattern (86 [42%] had 2–4 joints involved and 20 [10%] had >4 joints involved), with the most frequently involved joints being the hip (88 [43%] of 207) and knee (81 [39%]). On multivariable analysis, limb bone pain was the independent variable most strongly associated with cancer (odds ratio [OR] 87·80 [95% CI 18·89–408·12]), followed by weight loss (59·88 [6·34–565·53]), thrombocytopenia (12·67 [2·40–66·92]), monoarticular involvement (11·30 [4·09–31·19]), hip involvement (3·30 [1·13–9·61]), and male sex (2·40 [1·03–5·58]). Factors independently associated with juvenile idiopathic arthritis were morning stiffness (OR 0·04 [95% CI 0·01–0·20]), joint swelling (0·03 [0·01–0·09]), and involvement of the small hand joints (0·02 [0–1·05]). Interpretation Our study provides detailed information about presenting musculoskeletal manifestations of childhood cancers and highlights the clinical and laboratory features that are most helpful in the differential diagnosis with juvenile idiopathic arthritis. Funding Associazione Lorenzo Risolo.

Malignant histiocytoses (MHs) are a group of accessory cell-derived neoplasms, traditionally sub-classified into histiocytic sarcoma, interdigitating cell sarcoma, Langerhans cell (LC) sarcoma and ...

Few studies have detected qualitative and quantitative aspects of patients who underwent HSCT during childhood. The aims of this study are to explore the most recurrent narrative themes of HSCT experience in families five years after the procedure, and to observe statistical correlations between meaning attributed to the experience and defined variables.Thirty-five families of pediatric HSCT survivors participated in the research. Both survivors and their families were asked to write a brief composition about their disease experiences. Qualitative analysis of the texts was performed using the T-LAB software. Information about medical aspects and psychological problems in HSCT survivors were collected with interviews and administering the Child Behavior Checklist 6-18.HSCT survivor families that reported the presence of externalizing and internalizing symptoms focused on thematic areas concerning broken families with separation between parents and the affected child versus healthy children.Long term psychological problems seem to be connected to the perception of family disruption. Specifically, family relationships seem to be the factor that protects from or enhances the risk of psychopathology in HSCT survivors. Moreover, the use of metaphoric terms to refer to HSCT presents higher associations with psychopathology. On the contrary, the possibility of referring directly to the transplantation is associated with psychological well-being. It is important to consider the family as a group in order to improve care.

Poor graft function (PGF) is a severe complication of haematopoietic stem cell transplantation (HSCT) and administration of donor stem cell boosts (SCBs) represents a therapeutic option. We report 50 paediatric patients with PGF who received 61 boosts with CD34+ selected peripheral blood stem cells (PBSC) after transplantation from matched unrelated (n = 25) or mismatched related (n = 25) donors. Within 8 weeks, a significant increase in median neutrophil counts (0·6 vs. 1·516 × 109 /l, P < 0·05) and a decrease in red blood cell and platelet transfusion requirement (median frequencies 1 and 7 vs. 0, P < 0·0001 and

To describe incidence, causes, and outcomes related to pediatric intensive care unit (PICU) admission for patients undergoing hematopoietic stem cell transplantation (HSCT), we investigated the risk factors predisposing to PICU admission and prognostic factors in terms of patient survival. From October 1998 to April 2015, 496 children and young adults (0 to 23 years) underwent transplantation in the HSCT unit. Among them, 70 (14.1%) were admitted to PICU. The 3-year cumulative incidence of PICU admission was 14.3%. The main causes of PICU admission were respiratory failure (36%), multiple organ failure (16%), and septic shock (13%). The overall 90-day cumulative probability of survival after PICU admission was 34.3% (95% confidence interval, 24.8% to 47.4%). In multivariate analysis, risk factors predisposing to PICU admission were allogeneic HSCT (versus autologous HSCT, P = .030) and second or third HSCT (P = .018). Characteristics significantly associated with mortality were mismatched HSCT (P = .011), relapse of underlying disease before PICU admission (P .001), acute respiratory distress syndrome at admission (P = .012), hepatic failure at admission (P = .021), and need for invasive ventilation during PICU course (P .001). Our data indicate which patients have a high risk for PICU admission after HSCT and for dismal outcomes after PICU stay. These findings may provide support for the clinical decision-making process on the opportunity of PICU admission for severely compromised patients after HSCT.

Diffuse large B-cell Lymphoma (DLBCL) secondary to a chronic severe Epstein-Barr virus (EBV) infection has not been previously described in a patient with trisomy 21. Here we report the case of a 14-year-old girl with trisomy 21 with impaired control of EBV and DLBCL. She was cured with dose-adapted chemotherapy and hematopoietic stem cell transplantation without severe treatment-related toxicity. We describe the first case of EBV-positive DLBCL in a patient with trisomy 21 and we propose a treatment modality for this rare entity.

Haploidentical transplantation in children can extend the opportunity for transplantation to almost every patient lacking a human leukocyte antigen (HLA)–matched donor and offer this treatment to every child with an otherwise incurable disease. Although initial attempts were associated with a high transplant-related mortality, recent insights into the biology of haploidentical transplantation, the availability of effective ex vivo large-scale graft-manipulation technology, and improved supportive care strategies have led to significantly better outcomes. Concurrently, the indication for haploidentical transplantation has been extended, including different malignant and nonmalignant conditions. Worldwide donor registries include mainly donors of Caucasian origin. Patients of non-Caucasian origin have a lower chance of finding a suitable unrelated donor. Haploidentical transplantation allows the treatment of children independently of their ethnic background in a timely fashion. One of the major advantages of using a related donor is the possibility of collecting or generating additional cellular products from the same donor to open the possibility of enhancing both the antitumor effects of the graft and the immunologic reconstitution after transplantation.

International audience; Cet article présente les résultats de notre analyse automatique d'un corpus de débats sur le théâtre (16 ème-19 ème siècle). Notre objectif est d'illustrer le rôle important que jouent les expressions de l'ironie dans la polémique autour du théâtre et de mettre en évidence la position des auteurs ou des autorités antiques citées vis-à-vis des spectacles. Les résultats obtenus sont encourageants malgré la difficulté de la tâche et ils nous permettent de comparer d'une façon inédite les textes des auteurs défenseurs avec ceux des auteurs pourfendeurs du théâtre, ce qui offre une meilleure compréhension de certains arguments et stratégies d'auteurs dans le champ de la controverse.

Hepatic focal nodular hyperplasia (FNH) is a nonmalignant condition rarely affecting children previously treated for cancer, especially those who received hematopoietic SCT (HSCT). Some aspects of its pathogenesis still remain unclear and a strong association with specific risk factors has not yet been identified. We report here a single institution's case series of 17 patients who underwent HSCT and were diagnosed with FNH, analyzing retrospectively their clinical features and the radiological appearance of their hepatic lesions. We aimed to compare the diagnostic accuracy of ultrasound (US) and magnetic resonance imaging (MRI) and to explore the role of transient elastography (FibroScan) to evaluate the degree of hepatic fibrosis in FNH patients. Our analysis showed an association of FNH with age at transplant ⩽12 years (hazard ratio (HR) 9.10); chronic GVHD (HR 2.99); hormone-replacement therapy (HR 4.02) and abdominal radiotherapy (HR 4.37). MRI proved to be a more accurate diagnostic tool compared with US. Nine out of 12 patients who underwent FibroScan showed hepatic fibrosis. Our study points out that FNH is an emerging complication of HSCT, which requires a lifelong surveillance to follow its course in cancer patients.

Background: Patients who undergo pediatric Hematopoietic Stem Cell Transplantation (HSCT) may experience long-term psychological sequelae and poor Quality of Life (QoL) in adulthood. This study aimed to investigate subjective illness experience, QoL, and psychopathology in young adults who have survived pediatric HSCT. Method: The study involved patients treated with HSCT in the Hematology-Oncology Department between 1984 and 2007. Psychopathology and QoL were investigated using the SCL-90-R and SF-36. Socio-demographic and medical information was also collected. Finally, participants were asked to write a brief composition about their experiences of illness and care. Qualitative analysis of the texts was performed using T-LAB, an instrument for text analysis that allows the user to highlight the occurrences and co-occurrences of lemma. Quantitative analyses were performed using non-parametric tests (Spearman correlations, Kruskal-Wallis and Mann-Whitney tests). Results: Twenty-one patients (9 males) participated in the study. No significant distress was found on the SCL-90 Global Severity Index, but it was found on specific scales. On the SF-36, lower scores were reported on scales referring to bodily pain, general health, and physical and social functioning. All the measures were significantly (p < 0.05) associated with specific socio-demographic and medical variables (gender, type of pathology, type of HSCT, time elapsed between communication of the need to transplant and effective transplantation, and days of hospitalization). With regard to the narrative analyses, males focused on expressions related to the body and medical therapies, while females focused on people they met during treatment, family members, and donors. Low general health and treatment with autologous HSCT were associated with memories about chemotherapy, radiotherapy, and the body parts involved, while high general health was associated with expressions focused on gratitude (V-Test ± 1.96). Conclusion: Pediatric HSCT survivors are more likely to experience psychological distress and low QoL in adulthood compared with the general population. These aspects, along with survivors' subjective illness experience, show differences according to specific medical and socio-demographic variables. Studies are needed in order to improve the care and long-term follow-up of these families.

Poor graft function (PGF) is a severe complication of haematopoietic stem cell transplantation (HSCT) and administration of donor stem cell boosts (SCBs) represents a therapeutic option. We report 50 paediatric patients with PGF who received 61 boosts with CD34

Background and objectives Lack of suitable donors and regimen related toxicity are major barriers for hematopoietic stem cell transplantation (HSCT) in patients with sickle cell disease (SCD) when employing the most frequently used Busulfan-based conditioning regimen. The aim of the study is the assessment of efficacy and toxicity of Treosulfan-based conditioning regimen for SCD also when alternative donors such as mismatched unrelated donor and haploidentical donor are employed.Methods We report our single-center experience: 11 patients with sickle cell disease received HSCT with a Treosulfan/Thiotepa/Fludarabine/Anti-thymoglobulin conditioning regimen between 2010 and 2015. The donor was a matched sibling donor (n= 7), a haploidentical parent (n= 2), a matched unrelated donor (n= 1) or a mismatched unrelated donor (n=1). The haploidentical and mismatched unrelated donor grafts were manipulated by removing TCRαβ and CD19 positive cells.Results All patients survived the procedure and achieved stable engraftment. Stable mixed chimerism but no SCD manifestation was observed in 5/11 patients. Grade III-IV regimen related toxicity was limited to mucositis and no grade III-IV graft-versus-host disease (GvHD) was observed. Organ function evaluation showed no long term pulmonary, cardiac or renal toxicity; cerebral vasculopathy improved in 3/5 evaluable patients. Gonadal failure was observed in 1/4 evaluable patients.Conclusion Our data suggest that Treosulfan retains the myeloablative potential of Busulfan while reducing the toxicity also when haploidentical or unrelated donors are employed.

International audience; Dans cet article, nous proposons un moyen pour aider l'utilisateur à comprendre et apprendre un corpus littéraire grâce à la technique des Îles de Mémoire.

TCRαβ CD19 depletion in allogeneic haematopoietic stem cell transplantation performed for Hurler syndrome

International audience; Le projet « Haine du théâtre » du Labex Obvil est né du sentiment que l'heure était venue d'avoir une vue surplombante sur les polémiques théâtrales qui se sont développées dans une grande partie de l'Europe, entre le milieu du XVI e et celui du XIX e siècle. Elles avaient fait l'objet d'études ponctuelles 2 , mais personne n'avait essayé d'embrasser, dans son ensemble, une production pléthorique et très répétitive. Ce ressassement n'exclut pas, du reste, de fortes différences d'un pays à l'autre et d'étranges inversions. Quand la bataille fait rage en Angleterre, au tournant des XVI e et XVII e siècles, elle semble presque inexistante en France ; quand la polémique se tarit en Angleterre, avec la prise de pouvoir des puritains puis la Restauration, elle prend une force et une évidence inédite en France dans les années 1660 et suivantes, où sont publiés les pamphlets les plus retentissants (Conti, Nicole, Voisin et Bossuet). Pour dominer une telle masse de documents, sur une base européenne, il fallait réunir une équipe internationale. Celle-ci s'est fixé un double objectif. La première tâche était documentaire : il s'agissait de recenser un corpus proliférant et mal exploré, d'établir des bibliographies plus complètes et de rassembler, à usage interne, des fac-similés des textes. Le second objectif était d'analyser ces documents, dans une série de séminaires, journées d'étude, colloques et publications 3. LA CONVERSION NUMÉRIQUE DU PROJET « HAINE DU THÉÂTRE » Les humanités numériques (HN) se sont greffées sur un projet qui était, au départ, très « classique ». Peu ou pas formés au numérique, nous avons tout d'abord considéré les HN comme un moyen de mettre à la portée des chercheurs des textes dont beaucoup sont rares et certains inconnus : il s'agissait pour nous, essentiellement, de mettre en ligne un corpus commodément accessible. L'intégration dans le Labex Obvil nous a poussés à privilégier le corpus français, parce qu'il s'intégrait mieux avec les projets des autres équipes qui, au départ, travaillaient uniquement sur la France 4. En outre, le corpus français était moins 1 Ce travail a bénéficié d'une aide d'État gérée par l'Agence Nationale de la Recherche dans le cadre des Investissements d'Avenir portant la référence ANR-11-IDEX-0004-02. Nous remercions Frédéric Glorieux et Vincent Jolivet, ingénieurs à l'Obvil, sans l'aide desquels il n'aurait pas été possible. Ubaldo Floris, Teorici, teologi e istrioni. Per e contro il teatro nella Francia del Cinque-Seicento, Rome, Bulzoni, 2008 ; Donatella Pallotti et Paola Pugliati, dir., La Guerra dei teatri. Le controversie sul teatro in Europa dal secolo XVI alla fine del Ancien Régime, Pisa, ETS, 2008 ; Déborah Blocker, Instituer un « art ». Politiques du théâtre dans la France du premier XVII e siècle, Paris, Champion, 2009. 3 Voir le site du projet, http://obvil.paris-sorbonne.fr/projets/la-haine-du-theatre. 4 Ce corpus polémique est susceptible de s'articuler à la Bibliothèque critique numérique de l'Obvil : si ces textes ne relèvent pas de la critique à proprement parler, ils s'appuient néanmoins sur un système de valeurs qui contribue à construire les normes et les canons de la production dramatique et plus largement littéraire, que ce

The term ‘mono-histiocytic system’ groups a wide spectrum of cells which probably derive from a common hematopoietic progenitor in the bone marrow (BM). These cells can be divided into two main cat...

Haploidentical TCR A/B and B-cell depleted hematopoietic SCT in pediatric SAA and aspergillosis

Acute graft-versus-host disease (aGVHD) is the major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. Systemic steroid treatment represents the first-line therapy for aGVHD and is associated with a response rate of 30% to 60%. Steroid-resistant patients have a poor prognosis with high transplantation-related mortality (TRM). Several second-line therapies have been proposed for the management of unresponsive aGVHD, without proven beneficial effects on patients' outcome or overall long-term survival. For these reasons, extracorporeal photochemotherapy/photopheresis (ECP), a cell-based approach to control GVHD that spares generalized immunosuppression, seems to be promising. In this study, we report the outcome of 72 consecutive pediatric patients treated with ECP between 1997 and 2013 for aGVHD. Among them, 21 patients had steroid-resistant aGVHD, 42 had steroid-dependent aGVHD, and 9 did not receive steroid as first-line therapy because of clinical contraindications. A complete response was obtained in 72% of patients, a partial response was observed in 11%, and there was no response in 17% of patients. At day +180, TRM was 4% in the whole cohort; TRM was 3% and 20% among responders and nonresponders to ECP, respectively (P < .0001). The 5-year overall survival was 71%, showing a difference between responders and nonresponders of 78% and 30%, respectively (P = .0004). The 5-year time to progression of primary disease was 81%, without any significant difference between the 2 groups. Moreover, the 5-year progression-free survival of primary disease was 72%, with a significant difference (P = .0007) between responders (79%) and nonresponders (30%) to ECP. In conclusion, this study demonstrates that ECP is highly effective in aGVHD without a negative impact on primary disease., Highlights • We conducted a retrospective study of 72 consecutive pediatric patients treated with extracorporeal photochemotherapy/photopheresis for acute graft-versus-host disease. • Twenty-one steroid-refractory, 21 steroid-dependent, and 30 patients with infectious complications were included. • The infectious complications group included 9 with no steroids before extracorporeal photochemotherapy/photopheresis and 21 with steroids. • Outcomes at the end of extracorporeal photochemotherapy/photopheresis were complete remission, 72%; transplantation-related mortality day +180, 4%; 5-year overall survival, 71%; time to progression, 81%; and progression-free survival, 72%. • Extracorporeal photochemotherapy/photopheresis was highly effective in acute graft-versus-host disease without negative impact on primary disease.

International audience; This paper proposes a method to explore a collection of texts with an ontology depending on a particular point of view. In the first part, the paper points out the characteristics of the corpus, composed of 17th century French texts. In the second part, it explains the methodology to isolate the discriminant terms for the ontology creation. Furthermore, not only the projection of the ontology on the texts is pointed out, but also how to explore the corpus thanks to the defined perspective based on semantic fields.

Le projet « Haine du theâtre » du Labex Obvil est ne du sentiment que l'heure etait venue d'avoir une vue surplombante sur les polemiques theâtrales qui se sont developpees dans une grande partie de l'Europe, entre le milieu du XVI e et celui du XIX e siecle. Elles avaient fait l'objet d'etudes ponctuelles 2 , mais personne n'avait essaye d'embrasser, dans son ensemble, une production plethorique et tres repetitive. Ce ressassement n'exclut pas, du reste, de fortes differences d'un pays a l'autre et d'etranges inversions. Quand la bataille fait rage en Angleterre, au tournant des XVI e et XVII e siecles, elle semble presque inexistante en France ; quand la polemique se tarit en Angleterre, avec la prise de pouvoir des puritains puis la Restauration, elle prend une force et une evidence inedite en France dans les annees 1660 et suivantes, ou sont publies les pamphlets les plus retentissants (Conti, Nicole, Voisin et Bossuet). Pour dominer une telle masse de documents, sur une base europeenne, il fallait reunir une equipe internationale. Celle-ci s'est fixe un double objectif. La premiere tâche etait documentaire : il s'agissait de recenser un corpus proliferant et mal explore, d'etablir des bibliographies plus completes et de rassembler, a usage interne, des fac-similes des textes. Le second objectif etait d'analyser ces documents, dans une serie de seminaires, journees d'etude, colloques et publications 3. LA CONVERSION NUMERIQUE DU PROJET « HAINE DU THEÂTRE » Les humanites numeriques (HN) se sont greffees sur un projet qui etait, au depart, tres « classique ». Peu ou pas formes au numerique, nous avons tout d'abord considere les HN comme un moyen de mettre a la portee des chercheurs des textes dont beaucoup sont rares et certains inconnus : il s'agissait pour nous, essentiellement, de mettre en ligne un corpus commodement accessible. L'integration dans le Labex Obvil nous a pousses a privilegier le corpus francais, parce qu'il s'integrait mieux avec les projets des autres equipes qui, au depart, travaillaient uniquement sur la France 4. En outre, le corpus francais etait moins 1 Ce travail a beneficie d'une aide d'Etat geree par l'Agence Nationale de la Recherche dans le cadre des Investissements d'Avenir portant la reference ANR-11-IDEX-0004-02. Nous remercions Frederic Glorieux et Vincent Jolivet, ingenieurs a l'Obvil, sans l'aide desquels il n'aurait pas ete possible. Ubaldo Floris, Teorici, teologi e istrioni. Per e contro il teatro nella Francia del Cinque-Seicento, Rome, Bulzoni, 2008 ; Donatella Pallotti et Paola Pugliati, dir., La Guerra dei teatri. Le controversie sul teatro in Europa dal secolo XVI alla fine del Ancien Regime, Pisa, ETS, 2008 ; Deborah Blocker, Instituer un « art ». Politiques du theâtre dans la France du premier XVII e siecle, Paris, Champion, 2009. 3 Voir le site du projet, http://obvil.paris-sorbonne.fr/projets/la-haine-du-theatre. 4 Ce corpus polemique est susceptible de s'articuler a la Bibliotheque critique numerique de l'Obvil : si ces textes ne relevent pas de la critique a proprement parler, ils s'appuient neanmoins sur un systeme de valeurs qui contribue a construire les normes et les canons de la production dramatique et plus largement litteraire, que ce

An 8-year old boy, affected by severe aplastic anemia, developed a probable pulmonary invasive aspergillosis (IA) early after a second unrelated allogeneic hematopoietic stem cell transplant (HSCT). He was treated promptly with the combination of liposomal amphotericin B and caspofungin. Despite the initial stabilization, the patient deteriorated and the antifungal therapy was switched to voriconazole and caspofungin. The patient gradually improved and was discharged home on day +29 post-HSCT on oral voriconazole. On day +119, a sudden episode of hemoptysis occurred and a right superior lobectomy was decided to remove the residual aspergilloma. The patient is now alive and well more than 24 months from HSCT. This case demonstrated that antifungal combination therapy and surgery are valid options to cure pulmonary IA even in patients at high-risk and severely immunosuppressed.

Attraverso l’esplorazione degli usi del comico, Nathalie Grande contribuisce a definire l’estetica della galanteria nelle finzioni narrative in prosa della seconda meta del xvii secolo. Evidenziando la continuita che si delinea tra il xvii e il xviii secolo, sia sul piano letterario che su quello delle idee, l’A. tenta di correggere l’immagine del Grand Siecle troppo spesso appiattita sull’estetica del classicismo. Da un lato l’A. riesamina la funzione liberatoria del riso e del sorriso, dall...

Omaggio al celebre studioso Christopher J. Gossip, professore emerito all’Universita di New England, Australia, questo volume racchiude tredici saggi sul Seicento francese. Essi affondano le radici in una delle aree di ricerca predilette dallo studioso e si diramano in tre linee principali: la ripresa di temi antichi nella letteratura francese del Seicento, il riadattamento di soggetti identici da parte di autori diversi e l’influenza che alcuni scrittori del diciassettesimo secolo ebbero nel...

Edito da Jean Sgard, professore emerito dell’universita di Grenoble III, questo volume accoglie, insieme ad un’importante introduzione, l’edizione moderna di due opere attribuite a Francois Chauvigny de la Bretonniere, Venus dans le cloitre ou la Religieuse en chemise e Le Cochon mitre. Giornalista, romanziere e libertino, Chauvigny ebbe una breve carriera letteraria della durata di soli cinque anni. Prima di cio, il silenzio del chiostro benedettino, dopo, quello della prigione. Venus dans l...