128 results on '"Chiara Cadeddu"'
Search Results
2. Integrating China in the International Consortium for Personalised Medicine: a position paper on innovation and digitalization in Personalized Medicine
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Flavia Beccia, Marzia Di Marcantonio, Francesco Andrea Causio, Lena Schleicher, Lili Wang, Chiara Cadeddu, Walter Ricciardi, and Stefania Boccia
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European Union ,China ,Big Data ,ICT solutions ,Innovation ,funding ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background The advent of Personalized Medicine (PM) holds significant promise in revolutionizing healthcare by tailoring treatments to individual patients based on their data. However, its successful implementation requires the seamless integration of innovative technologies and presents formidable challenges in terms of sustainability. To tackle these challenges head-on, the International Consortium for Personalized Medicine (ICPerMed) was established, and the IC2PerMed project, as part of this consortium, seeks to foster collaboration between the European Union (EU) and China in the field of Personalized Medicine. Based on the results collected by the project, the objective of this study is to discern the key priorities for the implementation of Personalised Medicine concerning Information and Communication Technologies (ICT) and Big Data and digital solutions, with a particular emphasis on data management and protection. Methods A Delphi survey was conducted to gather expert’s consensus on the main priorities for actions on Information and Communication Technologies (ICT) and Big Data and digital solutions in the field of Personalized Medicine. Results The survey identified seven priorities in the area of Big Data and digital solutions, including data interoperability, standards, security measures, and international partnerships. Additionally, twelve priorities were identified for the innovation-to-market process, emphasizing cost-effectiveness, need assessment, and value definition in resource allocation. Conclusions The effective implementation of new technologies in Personalized Medicine research and practice is essential for the advancement of healthcare systems in both the European and Chinese contexts. The identified priorities play a pivotal role in promoting the sustainability of health systems and driving innovation in the implementation of Personalized Medicine. Addressing challenges related to data interoperability, standards, security, international collaboration, cost-effectiveness, and value assessment is of utmost importance in order to propel the progress of Personalized Medicine in healthcare systems.
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- 2024
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3. PERSIST: a pre–post study to assess an educational methodology to enhance youth climate literacy and systems thinking ability
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Doris Zjalic, MD, Alessio Perilli, MD, Lorenza Nachira, MD, Gaia Surya Lombardi, MD, and Chiara Cadeddu, PhD
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Environmental sciences ,GE1-350 - Abstract
Background: Education has a pivotal role in preparing society to address the forthcoming health impacts of the climate crisis. Education provides the tools necessary to instil both individual and collective attitudes for mitigating climate change, fosters the development of adaptive skills and mindsets, and promotes a critical understanding of climate change. The aim of the PERSIST project was to assess the effectiveness of a school educational intervention to strengthen literacy on the climate crisis, pro-environmental behaviours, and systems thinking in high school students (aged 14–18 years). Methods: Three meetings were carried out in a scientific high school in the suburbs of Rome (Italy) between March 21, and April 12, 2023, using complex systems models, group activities, and collective discussions. Pre-intervention and post-intervention questionnaires were administered to students to record knowledge, climate-related emotions, and pro-environmental behaviours. Questionnaires that were complete were considered valid. The anonymously collected data were processed using descriptive statistics and t test. Findings: A total of 273 students in ten different classes attending between grades 1 and 4 took part in the project. 78 (36%) participants were female, 133 (62%) were male, and four (2%) did not disclose their gender. The mean age was 15 years. We received 211 pairs of valid pre-intervention and post-intervention questionnaires. The preliminary analysis showed an average increase of 19% in correct responses to knowledge questions, a 21·2% increase in pro-environmental behaviours, and no discernible differences in climate-related emotions between pre-intervention and post-intervention questionnaires. Interpretation: An interactive approach and the use of complex systems might improve students' literacy and attitudes towards the climate crisis, without increasing negative ecological emotions. This pilot project can guide similar, repeatable programmes in other schools and countries and it represents the first measure of climate-related emotions after school intervention. Funding: None.
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- 2024
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4. Integrating China in the international consortium for personalised medicine. a position paper on healthcare professionals’ education and citizens’ empowerment in personalised medicine
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Flavia Beccia, Francesco Andrea Causio, Ilda Hoxhaj, Hui-Yao Huang, Lily Wang, Wenya Wang, Sara Farina, Tommaso Osti, Cosimo Savoia, Chiara Cadeddu, Walter Ricciardi, and Stefania Boccia
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Personalised medicine ,Citizen empowerment ,Healthcare professionals ,European Union ,China ,Special aspects of education ,LC8-6691 ,Medicine - Abstract
Abstract Background Personalised medicine (PM) has been fostered by technological and medical advances, but all stakeholders, including healthcare professionals, citizens and policy makers, should achieve adequate health literacy to promote PM implementation. The “Integrating China in the International Consortium for Personalised Medicine” (IC2PerMed) project, funded by the International Consortium for Personalised Medicine, focuses on this issue by highlighting the need to educate healthcare professionals and empower citizens. Within the aforementioned project, building on a mapping of European and Chinese policies in PM, experts in the field of PM participated in an online workshop and a following two-round Delphi survey, in order to identify the priority areas of intervention for healthcare professionals’ education and curricula, engagement and empowerment of citizens and patients. Results Nine experts completed the survey and reached a consensus on seventeen priorities: seven were related to health professionals’ education and curricula, whereas ten on citizen and patients’ awareness and empowerment. Conclusion These priorities emphasized the importance of education and health literacy, multidisciplinary and international collaboration, public trust, and consideration of ethical, legal, and social issues. The present experience highlights the relevance of the involvement of stakeholders in informing decision-makers, developing appropriate national plans, strategies, and policies, and ensuring the adequate implementation of PM in health systems.
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- 2023
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5. A survey of experts on personalized medicine landscape in European Union and China
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Ilda Hoxhaj, Flavia Beccia, Alisha Morsella, Chiara Cadeddu, Walter Ricciardi, and Stefania Boccia
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Personalised Medicine ,Survey ,Europe ,China ,Policies ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Introduction Personalized Medicine (PM) is one of the main priorities of the research agenda of the European Commission and the focus of the European Coordination and Support Action titled “Integrating China into the International Consortium for Personalized Medicine” (IC2PerMed). Similar to the European focus, PM is a current priority of the Chinese Government, through dedicated policies and its five-year investment plans. In the context of IC2PerMed, we implemented a survey to understand the state of the art of the implementation of PM related policies in EU and China, and to identify opportunities for future Sino-European collaborations. Methods The survey was elaborated by the IC2PerMed consortium and validated by a focus group of experts. The final version, in English and Chinese, was administered online to a pool of accurately selected experts. Participation was anonymous and voluntary. The survey consists of 19 questions in 3 sections: (1) personal information; (2) policy in PM; (3) facilitating and hindering factors for Sino-European collaboration in PM. Results Forty-seven experts completed the survey, 27 from Europe and 20 from China. Only four participants were aware of the implementation of PM-related policies in their working country. Expert reported that PM areas with greatest policy impact so far were: Big Data and digital solutions; citizen and patient literacy; and translational research. The main obstacles found were the lack of shared investment strategies and the limited application of scientific developments in clinical practice. Aligning European and Chinese efforts, finding common ground across cultural, social, and language barriers, were considered as actions needed to enhance efforts in applying PM strategies internationally. Conclusion To achieve efficiency and sustainability of health systems, it remains crucial to transform PM into an opportunity for all citizens and patients with the commitment of all the stakeholders involved. The results obtained aim to help define common research and development approaches, standards and priorities and increase collaboration at international level, as well as provide key solutions to enable convergence towards a common PM research, innovation, development and implementation approach between Europe and China.
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- 2023
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6. Increasing urban health awareness in adolescents using an interactive approach: evidence from a school-based pre-post pilot study in Rome, Italy
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Doris Zjalic, Alessio Perilli, Lorenza Nachira, Teresa Eleonora Lanza, Giuseppe Santoli, Andrea Paladini, Walter Ricciardi, and Chiara Cadeddu
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Interactive education ,Climate change ,Youth ,Planetary health ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Cities contribute to and are affected by the climate crisis, determining significant health issues in urban settings. Educational institutions have a privileged position to contribute to achieving the transformations needed for a healthier future, so Urban Health education is fundamental to empowering the health of the youth living in cities. This study aims to measure and raise the awareness of Urban Health among students attending a high school in Rome (Italy). Methods An interactive educational intervention, consisting of four sessions, was conducted in a Roman high school during spring 2022. Overall, 319 students aged between 13 and 18 attended the sessions and were asked to complete a 11-items questionnaire before and another after the interventions. Data was gathered anonymously and analyzed using descriptive and inferential statistics. Results Fifty-eight percent of respondents improved their post-intervention questionnaire score, while 15% did not improve and 27% got worse. The mean score significantly improved after the intervention (p
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- 2023
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7. Towards planetary health systems: a manifesto for a revised quadruple aim for healthcare improvement
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Alessio Perilli, Andrea Adduci, Walter Ricciardi, Antonio Giulio de Belvis, and Chiara Cadeddu
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human behavior ,policies ,politics and governance ,social value ,Environmental sciences ,GE1-350 - Abstract
Abstract Non-technical summary Healthcare systems significantly impact the environment, which in turn affects human health. To address this, we propose to revise a popular framework for healthcare improvement, by introducing the advancement of planetary health (the health of both humans and the natural systems) among the aims that health systems should pursue. This approach suggests reducing medical service needs through disease prevention, minimizing environmental impacts, and supporting global efforts to protect planetary health. Practical applications to bring about these pathways are documented in the literature. Technical summary Restoring the health of the planet, with concurrent benefits for human civilization, is paramount. Healthcare systems play a crucial role in this regard, considering the environmental impact of health services. Widely recognized approaches to designing healthcare systems for the optimization of their performance are based on the pursuit of multiple aims, such as the Triple Aim and Quadruple Aim frameworks. The objective of this work is to revise the latter by substituting ‘Advance Planetary Health’ for ‘Improve Population Health’. The objective of advancing planetary health supports all other pre-existing objectives: lowering costs, enhancing patient experience, team wellbeing, and population health, which directly relates to planetary health. Health systems promoting planetary health reduce the need for medical services through disease prevention and health promotion, pursue the provision of appropriate care, minimize the overall environmental impact of medical services, and support planetary health initiatives across all sectors and society. Multiple interconnected pathways exist to operationalize the above components. A revised quadruple aim for healthcare improvement, aligned with social and economic goals of sustainable prosperity and wellbeing, may be a desirable step toward constructing planetary health systems capable of maximizing the health of humans and natural systems. Social media summary It's time for new ‘planetary health systems’: focusing on planetary health to enhance healthcare performance. #PlanetaryHealth #ClimateCrisis #HealthcareImprovement.
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- 2024
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8. Use of oxygen-ozone therapy to improve the effectiveness of antibiotic treatment on infected arthroplasty: protocol for a superiority, open-label, multicentre, randomised, parallel trial
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Walter Ricciardi, Fidelia Cascini, Chiara Cadeddu, Marianno Franzini, Arnaldo Andreoli, Alfonso Manzotti, Gianluigi Quaranta, and Andrea Gentili
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Medicine - Abstract
Introduction Surgical site infections still remain a major public health challenge and have become an increasing universal risk, especially for the implantation of orthopaedic devices.Unfortunately, the discovery and increasingly widespread use (especially the misuse) of antibiotics have led to the rapid appearance of antibiotic-resistant strains today; more and more infections are caused by microorganisms that fail to respond to conventional treatments.Oxygen-ozone therapy has been extensively used and studied for decades across various potential medical applications and has provided consistent effects with minimal side effects.This study aims to determine the superiority of oxygen-ozone therapy in combination with oral antibiotic therapy in patients with wound infections after an orthopaedic device implantation when compared with antibiotic therapy alone.Methods and analysis This is an open-label, multicentre, randomised, parallel-group study that aims to assess the efficacy and safety of oxygen-ozone therapy in combination with oral antibiotic therapy to treat infections in patients (male or female aged ≥18 years) having undergone surgery for the implant of an orthopaedic device. Patients must have at least one (but no more than three) postoperative wounds in the site of surgery (ulcers, eschars and sores) and at least one symptom (pain, burning, redness and malodour) and at least one sign (erythema, local warmth, swelling and purulent secretion) of infection of at least moderate intensity (score ≥2) in the target lesion at the screening visit (patients with wounds without signs of localised infection or with undermining wounds will be excluded).Patients (n=186) will be recruited from five Italian hospitals and studied for 7 weeks. All will be assigned to one of the two treatment groups according to a web-based, centralised randomisation procedure and placed into either the (1) intervention: oxygen-ozone therapy 2–3 times a week for 6 weeks (for a maximum of 15 sessions) simultaneously with an appropriate oral antibiotic therapy prescribed at baseline or (2) control: oral antibiotic therapy prescribed at baseline.The primary outcome is the efficacy and superiority of the treatment (ozone and oral antibiotic therapies); secondary outcomes include the resolution of signs and symptoms, modifications in lesion size and the treatment’s safety and tolerability.Ethics and dissemination This study has been reviewed and approved by the responsible Independent Ethics Committee (IEC) of COMITATO ETICO CAMPANIA NORD, located at ‘Azienda Ospedaliera San Giuseppe Moscati di Avellino’.After completion of the study, the project coordinator will prepare a draft manuscript containing the final results of the study on the basis of the statistical analysis. The manuscript will be derived by the co-authors for comments, and after revision, it will be sent to a major scientific journal. Findings will be disseminated via online and print media, events and peer-reviewed journals.Trial registration number NCT04787575.
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- 2024
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9. ASPHER Statement for COP28. A Call for Action in Seven Points
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Laurent Chambaud, Tara Chen, Chiara Cadeddu, Ana-Caterina Pinho-Gomes, Balázs Ádám, John Middleton, Susana Viegas, Nadav Davidovitch, Doris Zjalic, Flavia Pennisi, Lore Leighton, Robert Otok, Carlo Signorelli, and The ASPHER Climate and Health Working Group
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climate change ,health ,COP28 ,ASPHER ,Schools of Public Health ,Public aspects of medicine ,RA1-1270 - Published
- 2023
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10. Co-administration of SARS-CoV-2 and influenza vaccines in healthcare workers: Results of two vaccination campaigns in a large teaching hospital in Rome
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Domenico Pascucci, Alberto Lontano, Luca Regazzi, Eleonora Marziali, Mario Cesare Nurchis, Matteo Raponi, Giuseppe Vetrugno, Umberto Moscato, Chiara Cadeddu, and Patrizia Laurenti
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Co-administration ,vaccine ,SARS-CoV-2 ,COVID-19 ,influenza ,healthcare workers ,Immunologic diseases. Allergy ,RC581-607 ,Therapeutics. Pharmacology ,RM1-950 - Abstract
ABSTRACTThe concurrent administration of COVID-19 and influenza vaccines has arisen as a promising approach to bolster protection against respiratory pathogens and improve vaccination rates. However, there remains a lack of data regarding the prevalence of co-administration across several vaccination campaigns, especially among healthcare workers (HCWs). Therefore, this study aims to shed light on the acceptance of co-administration strategies among HCWs during the two campaigns following the introduction of the anti-SARS-CoV-2 vaccine. A retrospective cohort study was conducted among the HCWs of the Fondazione Policlinico Universitario “A. Gemelli” IRCCS, a research hospital in Rome. Hospital administrative databases were accessed to gather information about vaccination for SARS-CoV-2 and influenza during the 2021/2022 and 2022/2023 vaccination campaigns. The study included 7399 HCWs. The co-administration of anti-SARS-CoV-2 and influenza vaccines presented a significant rise in 2022/2023 compared to the previous vaccination campaign (+38%): this was confirmed for every professional category, with the largest increases among resident doctors (+47%) and physicians (+44%), and also for every age category, but it was particularly evident for the youngest health professionals. The probability of co-administration uptake during the 2022/2023 campaign was significantly higher for males, and for those that received co-administration during the 2021/2022 campaign, while the probability was lower for nurses and administrative staff. This study highlights the co-administration procedure as a valuable and effective tool in annual vaccination campaigns for SARS-CoV-2 and influenza. The procedure’s safety and streamlined logistics make it increasingly attractive for implementation, particularly among HCWs.
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- 2023
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11. Influenza vaccination coverage in pediatric population in Italy: an analysis of recent trends
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Floriana D’Ambrosio, Teresa Eleonora Lanza, Rosaria Messina, Leonardo Villani, Angelo Maria Pezzullo, Walter Ricciardi, Aldo Rosano, and Chiara Cadeddu
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Influenza ,Vaccination ,Italy ,Coverage ,Children ,Pediatrics ,RJ1-570 - Abstract
Abstract Background Influenza is a major cause of morbidity, mortality and exacerbation of extant chronic disease worldwide. Influenza vaccination is thus fundamental to reduce the burden of disease. In this study, we describe the trend of influenza vaccination coverage in the seasons 2010/11–2020/21 among children aged
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- 2022
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12. How Does Climate Change Worry Influence the Relationship between Climate Change Anxiety and Eco-Paralysis? A Moderation Study
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Matteo Innocenti, Alessio Perilli, Gabriele Santarelli, Niccolò Carluccio, Doris Zjalic, Daniela Acquadro Maran, Lorenzo Ciabini, and Chiara Cadeddu
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eco-anxiety ,climate change anxiety ,climate change anxiety scale ,climate change worry ,communicating climate change ,Science - Abstract
Climate change (CC) has a significant impact on human health, resulting in both physical and mental illnesses. Eco-anxiety—the excessive and pervasive fear about the consequences of CC—is the most studied psychoterratic state. This study presents the validation of Italian versions of Hogg’s Eco-Anxiety Scale (HEAS) and the Eco-Paralysis Scale. It also investigates the effects of worry on eco-anxiety and eco-paralysis. The study was conducted on 150 Italian individuals who responded to the two scales and to other questionnaires to make comparisons with the two above. Internal consistency and factorial structure were assessed through Cronbach’s alpha, Confirmatory Factor Analysis and Exploratory Factor Analysis. A median regression was used to assess the association between the EPS and the HEAS and Climate Change Worry Scale (CCWS) and their interaction. HEAS and EPS showed good psychometric properties: HEAS resulted in good internal consistency (Cronbach’s α = 0.986), and the Eco-Paralysis scale had good test-retest reliability (r = 0.988). In both cases, a one-factor structure was suggested to be retained. The interaction terms between HEAS and CCWS (β = −0.02; 95% CI: −0.03, −0.01; p < 0.001) and between HEAS and education (β = −0.05; 95% CI: −0.08, −0.02; p < 0.001) were significant. Therefore, the feeling of worry seems to act as a moderator between climate change anxiety and eco-paralysis since it may appear to influence individuals and their ability to transform anxiety into action. Education plays a role in reducing the risk of Eco-Paralysis in subjects affected by climate change anxiety. Thus, data suggest that working on reinforcing a more cognitive concern might result in more problem-solving-focused strategies to face climate change anxiety and eco-paralysis.
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- 2023
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13. Editorial for the Special Issue 'COVID-19 Vaccines: A Public Health Perspective'
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Chiara de Waure, Chiara Cadeddu, and Aldo Rosano
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n/a ,Medicine - Abstract
Public health is aimed at protecting and promoting citizens’ and communities’ health through different interventions, including vaccinations [...]
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- 2023
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14. Understanding the determinants of vaccine hesitancy and vaccine confidence among adolescents: a systematic review
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Chiara Cadeddu, Carolina Castagna, Martina Sapienza, Teresa Eleonora Lanza, Rosaria Messina, Manuela Chiavarini, Walter Ricciardi, and Chiara de Waure
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adolescents ,teenagers ,students ,vaccine ,vaccination ,hesitancy ,immunization ,confidence ,attitudes ,hpv ,Immunologic diseases. Allergy ,RC581-607 ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Vaccine hesitancy (VH) in the age of adolescence is a major public health issue, though it has not been widely examined in the scientific literature. This systematic review aims to address the determinants of VH among adolescents aged 10–19. PubMed, Scopus, and Web of Science were searched from the inception until 11 December 2020. Articles in English, assessing adolescents’ attitudes toward vaccination in terms of hesitancy and/or confidence were considered eligible. Out of 14,704 articles, 20 studies were included in the qualitative analysis. Quality assessment was performed through the Appraisal tool for Cross-Sectional Studies (AXIS). A better knowledge of vaccine-preventable diseases, a higher confidence in vaccines, as well as an active involvement in the decision-making process showed a positive relationship with adolescents’ vaccine uptake. These aspects should be considered to plan tailored interventions for the promotion of vaccination among adolescents and to reduce VH. Major limitations of this review are represented by the high heterogeneity of the tools used in the primary studies and the lack of standardization in outcomes definitions. Future research is needed to disentangle the interrelationship among the different determinants of VH in this age group.
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- 2021
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15. Knowledge, attitudes, and behaviors toward COVID-19 vaccination in a sample of Italian healthcare workers
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Luca Regazzi, Eleonora Marziali, Alberto Lontano, Leonardo Villani, Andrea Paladini, Giovanna Elisa Calabrò, Patrizia Laurenti, Walter Ricciardi, and Chiara Cadeddu
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covid-19 ,covid-19 vaccines ,vaccination hesitancy ,vaccination ,health knowledge and attitudes ,health personnel ,physicians ,surveys and questionnaires ,italy ,Immunologic diseases. Allergy ,RC581-607 ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Vaccine hesitancy in healthcare workers (HCWs) has been studied for various contagious diseases, but there is still insufficient knowledge about this phenomenon for COVID-19. We developed and validated a knowledge, attitude, and practice survey of 39 questions to assess Italian HCWs’ hesitancy toward vaccination in general (general hesitancy), COVID-19 vaccination (COVID-19 hesitancy), and public health injunctive measures (refusal of obligations). The survey was administered through a web platform between July and November 2021. Three multivariable logistic regressions were performed to evaluate the association between the explored dimensions of hesitancy and the potential determinants investigated. Out of 2,132 respondents with complete answers, 17.0% showed to be generally hesitancy toward vaccination, 32.3% were hesitant on COVID-19 vaccination, while 18.8% were categorized as refusing obligations. A significant protective effect against all three dimensions of hesitancy was found for increasing fear of COVID-19, advising COVID-19 vaccination to relatives and patients, having received flu vaccination in the previous year and having higher levels of education. Better self-rated knowledge about COVID-19 vaccines and reading up institutional sources were significantly protective against general and COVID-19 hesitancy, while being a physician rather than another healthcare professional was protective only against COVID-19 hesitancy. Conversely, increasing age and referring to colleagues to expand knowledge about COVID-19 were positively associated with COVID-19 hesitancy. The determinants of general hesitancy, COVID-19 hesitancy and the refusal of obligations are mostly overlapping. Given the great influence they exert on patients and communities, it is pivotal to limit HCWs vaccine hesitancy through appropriate training activities.
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- 2022
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16. Big data and ICT solutions in the European Union and in China: A comparative analysis of policies in personalized medicine
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Francesco Andrea Causio, Ilda Hoxhaj, Flavia Beccia, Marzia di Marcantonio, Timo Strohäker, Chiara Cadeddu, Walter Ricciardi, and Stefania Boccia
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Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
Introduction Several countries are either planning or implementing national strategies for the development and integration of Personalized Medicine (PM) into their healthcare systems. Personalized Medicine is an undisputed priority of the European Commission (EC), which has funded the project “Integrating China into the International Consortium for Personalized Medicine” (IC2PerMed), in order to ensure a common basis for Sino-European collaborations. By mapping the current PM landscape in the European Union (EU) and in China, IC2PerMed aims to provide key solutions toward a synergistic and coordinated approach in the field of PM. Methods An extensive desk research was conducted, aimed at identifying documents on PM-related policies, programs, and action plans in the EU and in China, published up to November 2020. The search was conducted by exploring scientific and gray literature, and official institutional repositories. A descriptive summary condensed the information retrieved for both. Results Since 2013, the year of publication of the first PM policy by the EC “Use of omics technologies in PM development,” several documents have been published. PM is a key element of the policy agenda also in China, which in 2016 integrated PM into the 13th National Five-Year Plan, followed by the publication of several policies on technology infrastructure and big data. Both in the EU and China, especially in recent years, these policies addressed in detail the issues of big data, data interoperability and exchange, while defining the standards of information and communication infrastructures. Conclusions In order to allow optimal collaboration, it is essential to understand similarities and differences between the respective policy strategies, with particular attention to data management and adopted infrastructures. The results of this project may enable the development of joint Sino-European research and innovation initiatives, promoting developments in the field of PM.
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- 2022
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17. Outcomes from the First European Planetary Health Hub Convening at ARTIS in Amsterdam
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Remco Kort, Jeremy Pivor, Josep M. Antó, Annemarie Bergsma, Peter J. Blankestijn, Olette Bollen, Egid van Bree, Joyce L. Browne, Judith de Bruin, Jasper Buikx, Chiara Cadeddu, Jennifer Cole, Francesca Costabile, Aimée de Croon, Anneliese Depoux, Ian Fussell, Bernhard Goodwin, Arte Groenewegen, Milo Grootjen, Jaana I. Halonen, Riitta-Maija Hämäläinen, Pieter ten Have, Martin Herrmann, Pauline de Heer, Godelieve van Heteren, Jopke Janmaat, Marija Jevtic, Hans Mulder, Nathalie Lambrecht, Vincenzo Lionetti, Camilla Alay Llamas, Maarten Manten, Pim Martens, Ariadna Moreno, Francine Müller, Cristina O’Callaghan-Gordo, Sara Muller, Cecilia Manosa Nyblon, Juliette Mattijsen, Hans Ossebaard, Karlien Pijnenborg, Nynke Postma, Lisa Pörtner, Marju Prass, Lekha Rathod, Alexandre Robert, Andrée Rochfort, Alexis Roig, Anja Schoch, Eva-Maria Schwienhorst-Stich, Ralf Klemens Stappen, Ingrid Stegeman, Jorieke van der Stelt, Peter Stenvinkel, Rembrandt Sutorius, Valesca Venhof, Martine Veenman, Leonardo Villani, Maike Voss, Michiel de Vries, Laura van der Zande, Andreea Zotinca, Arnau Queralt-Bassa, and Samuel S. Myers
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planetary health ,social justice ,transdisciplinary research ,biodiversity loss ,climate change ,Technology ,Science (General) ,Q1-390 - Abstract
A new network of over 72 organizations from 12 countries was activated during a convening at ARTIS in Amsterdam on 26–27 September 2022. Representatives are aligned with the transdisciplinary field and social movement of Planetary Health, which analyzes and addresses the impacts of human disruptions to natural systems on human health and all life on Earth. The new European Planetary Health Hub consists of organizations from various sectors, including universities, healthcare, youth, business, and civil society. The Convening, co-organized by the Planetary Health Alliance (PHA), the European Environment and Sustainable Development Advisory Councils Network (EEAC), and Natura Artis Magistra (ARTIS), aimed to develop Planetary Health Working Groups for Education, Policy Engagement, Research, and Movement Building. The Convening resulted in an outline for each of the Working Group’s aims, visions, missions, priorities, and activities, and set the framework for sustaining their activities in the future through the establishment of the European Planetary Health Hub Secretariat in the Netherlands. The Hub members shared lessons learned, built relationships, and developed artwork-inspired perspectives on Planetary Health. In conclusion, the Convening led to the establishment of a strong European foundation to contribute to the transformations needed for sustainable, just, and equitable societies that flourish within the limits of our ecosystems.
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- 2023
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18. Assessing Doubts, Knowledge, and Service Appreciation among Pregnant Women Who Received the COVID-19 Vaccination in an Italian Research Hospital: A Cross-Sectional Study
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Stefania Bruno, Lorenza Nachira, Paola Arcaro, Fabio Pattavina, Enrica Campo, Chiara Cadeddu, Brigida Carducci, Antonio Lanzone, Gianfranco Damiani, Patrizia Laurenti, and FPG COVID-19 Vaccination Team (FPG-CVT)
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pregnant women ,vaccine hesitancy ,COVID-19 ,occupational categories ,vaccine ,pandemic ,Medicine - Abstract
The COVID-19 pandemic is considered one of the deadliest pandemics in history. Pregnant women are more susceptible to developing serious diseases during COVID-19 than their non-pregnant peers. Pregnant women often express doubt about accepting the vaccination, especially in regard to their security and safety. This study aims to investigate the appreciation of the vaccination offer, and if there are any determinants impacting vaccine hesitancy. A questionnaire was administered to a sample of pregnant women who had just received their immunization against COVID-19 at the vaccination service of a teaching hospital in Rome, from October 2021 to March 2022. A high appreciation of the vaccination services was found, both for the logistic organization and the healthcare personnel, with mean scores above 4 out of 5. The degree of pre-vaccinal doubt was low (41%) or medium (48%) for the largest part of the sample, while the degree of COVID-19 vaccine knowledge was high for 91% of the participants. Physicians were the most decisive information source for the vaccination choice. Our results highlighted that a supportive approach could increase appreciation and improve the setting of vaccinations. Healthcare professionals should aim for a more comprehensive and integrated role of all figures.
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- 2023
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19. Factors Influencing the Choice to Advise for or against COVID-19 Vaccination in the Physicians and Dentists of an Italian Region
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Eleonora Marziali, Alberto Lontano, Luca Regazzi, Andrea Paladini, Leonardo Villani, Giovanna Elisa Calabrò, Gianfranco Damiani, Patrizia Laurenti, Walter Ricciardi, and Chiara Cadeddu
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vaccine hesitancy ,information sources ,physicians ,dentists ,COVID-19 vaccines ,Italy ,Medicine - Abstract
Healthcare workers (HCWs), particularly physicians, are a relevant and trusted source of information for patients, especially when health-related choices such as vaccination are concerned. Between July and November 2022, we administered a web-based survey to physicians and dentists living in the Latio region of Italy to explore whether their background might affect their willingness to recommend the COVID-19 vaccination to their patients (RCVtoPat) and their relatives (RCVtoRel). We performed a multivariable logistic regression to study the association between the two outcomes (RCVtoPat and RCVtoRel) and their potential determinants in our sample (n = 1464). We found that being a dentist, an increasing fear of COVID-19, and having been previously vaccinated against flu are positively associated with both RCVtoPat and RCVtoRel, while a better self-rated knowledge of COVID-19 vaccines is associated only with RCVtoRel. No role was found for age, sex, civil status, education level, information sources, previous SARS-CoV-2 infection, and chronic diseases. A sub-group analysis of physicians alone (n = 1305) demonstrated a positive association with RCVtoRel of being specialized in diagnostic/therapeutic services and a negative effect on RCVtoPat of being trained in general practice. We provide useful insights about the factors that should be addressed to ensure HCWs exert a positive influence on their patients and communities.
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- 2022
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20. Planning and Organization of the COVID-19 Vaccination Campaign: An Overview of Eight European Countries
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Chiara Cadeddu, Aldo Rosano, Leonardo Villani, Giovanni Battista Coiante, Ilaria Minicucci, Domenico Pascucci, and Chiara de Waure
- Subjects
COVID-19 vaccines ,immunization programs ,vaccination coverage ,Medicine - Abstract
The initial progress of the COVID-19 vaccination campaign worldwide depended on several aspects, including programmatic/practical issues. This paper focused on the planning and organization of COVID-19 vaccination campaigns in eight European countries (Sweden, Denmark, Romania, Hungary, Italy, Spain, Germany, and France), from the launch to August 2021. Information on the planning of the vaccination campaign (release and update of a national immunization plan, types of vaccines being used and their limitations/suspensions) and its organization (vaccination target groups, possibility of citizens’ choice, vaccination workforce and settings, vaccines procurement) were obtained through desk research of international and national reports, plans, and websites. Eventually, data on vaccination coverage were drawn from Our world in data and analyzed through join point regression. The eight countries showed differences in groups prioritization, limitations/suspensions of use of specific vaccines, citizens’ possibility to choose vaccines, and vaccination workforce involved. These issues could have contributed to the different progress towards high levels of vaccination coverage. In respect to vaccination coverage, Romania reached much lower levels than other countries. Further comparative research is needed in order to identify best practices in vaccination campaign that could be useful for the next phases of the COVID-19 pandemic, and be better prepared for future potential pandemic.
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- 2022
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21. Vaccine Hesitancy and Trust in the Scientific Community in Italy: Comparative Analysis from Two Recent Surveys
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Chiara Cadeddu, Martina Sapienza, Carolina Castagna, Luca Regazzi, Andrea Paladini, Walter Ricciardi, and Aldo Rosano
- Subjects
vaccine hesitancy ,European Social Survey ,scientific community ,trust ,vaccination ,public opinion ,Medicine - Abstract
Vaccination rates in Italy fell until 2015 because of unfounded safety concerns. Public education and a 2017 law on mandatory vaccination have boosted rates since then. The aim of our study is to explore how trust in the scientific community and attitudes towards vaccines have changed in the period of 2017–2019 in Italy. Data were extracted from the Italian section of the 2017 and 2019 editions of the European Social Survey (ESS). We compared the two surveys highlighting changes in public opinion on vaccines. A descriptive analysis of the socio-cultural variables according to the answers provided to key questions on the harmfulness of vaccines was conducted. Differences between percentages were tested by using the χ2 test. The association between the opinion about the harmfulness of vaccines and trust in the scientific community was analyzed through a logistic regression model. Compared to ESS8, ESS9 showed an increase in the percentage of respondents disagreeing with the harmfulness of vaccines. Trust in the scientific community raised in the period from 2017 to 2019 (59% vs. 69.6%). Higher education was significantly associated with disagreement regarding the harmfulness of vaccines (odds ratio (OR) = 2.41; 95% confidence interval (95%CI) 1.75–3.31), the strongest predictor was trust in the scientific community (OR = 10.47; 95% CI 7.55–14.52). In Italy, trust in the scientific community and in vaccinations has grown significantly in recent years, indicating a paradigm shift in public opinion compared to the past. Central actions and effective public communication strategies might reduce vaccine hesitancy and could be essential to garner public trust.
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- 2021
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22. Organisational Model and Coverage of At-Home COVID-19 Vaccination in an Italian Urban Context
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Elettra Carini, Chiara Cadeddu, Carolina Castagna, Mario Cesare Nurchis, Teresa Eleonora Lanza, Adriano Grossi, Andrea Barbara, Svetlana Axelrod, on behalf of the At Home COVID-19 Vax Team, Mauro Goletti, and Paolo Parente
- Subjects
at-home vaccination ,immunisation campaign ,SARS-CoV-2 ,organisational model ,Medicine - Abstract
The COVID-19 pandemic called for a reorganisation of the methods for providing health services. The aim of this paper is to describe the organisational model implemented by one of Rome’s Local Health Units (LHU), ASL Roma 1, for the “at-home COVID-19 vaccination campaign” dedicated to a target population and to outline data related to vaccination coverage stratified by health districts. A cross-sectional study was designed to describe the strategies implemented by LHU to deliver at-home vaccination programmes. People eligible for the at-home vaccination programme included patients living in the area of the LHU, being assisted by the district home care centre or not transportable or individuals with social situations that make traveling difficult. Priority for vaccination was given to (I) age > 80 years, (II) ventilated patients with no age limit, (III) very seriously disabled people with no age limit. Patients’ data were acquired from regional and LHU databases. From 5 February until the 16 May, 6127 people got at least one dose of Pfizer-Biontech Comirnaty® vaccine, while 5278 (86.14%) completed the necessary two doses. The highest number of vaccines was administered during the first week of April, reaching 1296 doses overall. The number of vaccines administered were similar across the districts. The average number of people vaccinated at home was 6 per 1000 inhabitants in the LHU. This model proved to be extremely complex but effective, reaching satisfying results in terms of vaccination coverage.
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- 2021
- Full Text
- View/download PDF
23. Research and innovation in personalized medicine: a descriptive synthesis of actors in the EU and China
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Francesco Andrea Causio, Ilda Hoxhaj, Flavia Beccia, Marzia Di Marcantonio, Timo Strohäker, Chiara Cadeddu, Walter Ricciardi, and Stefania Boccia
- Subjects
Pharmacology ,Molecular Medicine ,General Medicine - Abstract
Aim: Research and innovation (R&I) actors are fundamental in shortening the translational gap of personalized medicine in health systems. In the context of the ‘Integrating China in the International Consortium for Personalized Medicine’ project, we aimed to map the current landscape of R&I actors in the field of personalized medicine in the EU and China. Methods: A two-phase desk research study was conducted. Results: We identified 78 R&I actors. Research and technology organizations were the most frequent in both the EU and China. The identified R&I actors were active in a wide range of fields. The EU and China have many different R&I actors addressing personalized medicine-related issues, with few characteristics in common. Conclusion: More efforts are needed to ensure these R&I actors are encouraged to work together to bridge each other’s gaps.
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- 2023
24. Hospital-Territory Vaccination Center: pilot study on a multidisciplinary model for administration of recombinant zoster vaccine in fragile patients
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Silvia Martinelli, Luca Regazzi, Chiara Cadeddu, Antonietta Spadea, Enrica Tamburrini, Pierluigi Salvo, Silvia Bosello, Maria D'Agostino, Simona Sica, Francesco Landi, Rossella Mancini, Federica Rizzo, Domenico Pascucci, and Patrizia Laurenti
- Subjects
Health (social science) ,Epidemiology ,Health Policy ,Public Health, Environmental and Occupational Health ,Medicine (miscellaneous) ,Health Informatics - Published
- 2023
25. Health literacy related to health care, disease prevention, and health promotion in the Italian adult population
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Luigi Palmieri, Chiara Lorini, Chiara Cadeddu, Aldo Rosano, Chiara Donfrancesco, Guglielmo Bonaccorsi, Paola Castro, Cinzia Noce, Claudia Meduri, Matilde Bocci, Daniela Galeone, Graziano Onder, and Brigid Unim
- Subjects
Health (social science) ,Epidemiology ,Health Policy ,Public Health, Environmental and Occupational Health ,Medicine (miscellaneous) ,Health Informatics - Published
- 2023
26. Barriers and strength factors of adult immunization plans in seven countries of the European Region
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Gaia Lombardi, Serena Tumelero, Teresa Lanza, Andrea Paladini, Carolina Castagna, and Chiara Cadeddu
- Subjects
Health (social science) ,Epidemiology ,Health Policy ,Public Health, Environmental and Occupational Health ,Medicine (miscellaneous) ,Health Informatics - Published
- 2023
27. Italy's journey throughout the pandemic: sentiments and attitudes in 2 million tweets
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Andriy Melnyk, Andrea Agostini, Mario Nurchis, Gerardo Altamura, Chiara Cadeddu, Fidelia Cascini, and Walter Ricciardi
- Subjects
Health (social science) ,Epidemiology ,Health Policy ,Public Health, Environmental and Occupational Health ,Medicine (miscellaneous) ,Health Informatics - Published
- 2023
28. Ciguatera Fish Poisoning: an economic evaluation of healthcare costs and assessment of current level of awareness among islanders and visitors in three Caribbean Islands
- Author
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Alessio Perilli, Alisha Morsella, Walter Ricciardi, and Chiara Cadeddu
- Subjects
Health (social science) ,Epidemiology ,Health Policy ,Public Health, Environmental and Occupational Health ,Medicine (miscellaneous) ,Health Informatics - Published
- 2023
29. Sentiment towards vaccinations in Chinese healthcare workers: preliminary results from an international survey
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Luca Regazzi, Chiara Cadeddu, Angelica Gris, and Marta Lomazzi
- Subjects
Health (social science) ,Epidemiology ,Health Policy ,Public Health, Environmental and Occupational Health ,Medicine (miscellaneous) ,Health Informatics - Published
- 2023
30. Trust in the scientific community and conspiracy thinking in Italy during the COVID-19 pandemic
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Chiara Cadeddu, Luca Regazzi, and Aldo Rosano
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Health (social science) ,Epidemiology ,Health Policy ,Public Health, Environmental and Occupational Health ,Medicine (miscellaneous) ,Health Informatics - Published
- 2023
31. Occurrence of cardiopulmonary diseases after the Susa Valley wildfires of 2017
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Mattia Russo, Aldo Rosano, Chiara Cadeddu, Alessio Perilli, Luca Regazzi, Davide Ascoli, and Davide Vecchio
- Subjects
Health (social science) ,Epidemiology ,Health Policy ,Public Health, Environmental and Occupational Health ,Medicine (miscellaneous) ,Health Informatics - Published
- 2023
32. Diversity, equity and inclusion in public health: a multidisciplinary analysis
- Author
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Chiara Cadeddu
- Subjects
Health (social science) ,Epidemiology ,Health Policy ,Public Health, Environmental and Occupational Health ,Medicine (miscellaneous) ,Health Informatics - Published
- 2023
33. Covid-19 conspiracy beliefs, government legitimacy and societal priorities in the age of pandemic
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Aldo Rosano, Pasquale Padova, Luca Regazzi, and Chiara Cadeddu
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Health (social science) ,Epidemiology ,Health Policy ,Public Health, Environmental and Occupational Health ,Medicine (miscellaneous) ,Health Informatics - Published
- 2023
34. Assessing the predictive performance of published polygenic scores for prevalent and incident coronary artery disease in multiple genetic ancestries
- Author
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Luca Regazzi, Chiara Cadeddu, Stefania Boccia, George Busby, and Alessandro Bolli
- Subjects
Health (social science) ,Epidemiology ,Health Policy ,Public Health, Environmental and Occupational Health ,Medicine (miscellaneous) ,Health Informatics - Published
- 2023
35. Climate crisis and planetary health in italian medical schools’ curricula: a scoping review
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Doris Zjalic, Gaia Lombardi, Giulia Congedo, Alessio Perilli, Mattia Di Russo, and Chiara Cadeddu
- Subjects
Health (social science) ,Epidemiology ,Health Policy ,Public Health, Environmental and Occupational Health ,Medicine (miscellaneous) ,Health Informatics - Published
- 2023
36. Buffer spaces in healthcare facilities: strategies for managing and designing strategic areas
- Author
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Marco Gola, Daniele La Milia, Chiara Cadeddu, Francesco Altems, Barbara Altems, Raffaella Altems, Marcello Altems, Cristina Altems, Albino Altems, Giuseppe Altems, Alexander Johnson, Gianfranco Damiani, Carlo Altems, Maddalena Buffoli, Andrea Rebecchi, Stefano Capolongo, and Walter Ricciardi
- Subjects
Health (social science) ,Epidemiology ,Health Policy ,Public Health, Environmental and Occupational Health ,Medicine (miscellaneous) ,Health Informatics - Published
- 2023
37. Assessing Doubts, Knowledge, and Service Appreciation among Pregnant Women Who Received the COVID-19 Vaccination in an Italian Research Hospital: A Cross-Sectional Study
- Author
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(FPG-CVT), Stefania Bruno, Lorenza Nachira, Paola Arcaro, Fabio Pattavina, Enrica Campo, Chiara Cadeddu, Brigida Carducci, Antonio Lanzone, Gianfranco Damiani, Patrizia Laurenti, and FPG COVID-19 Vaccination Team (FPG-CVT) FPG COVID-19 Vaccination Team
- Subjects
pregnant women ,vaccine hesitancy ,COVID-19 ,occupational categories ,vaccine ,pandemic - Abstract
The COVID-19 pandemic is considered one of the deadliest pandemics in history. Pregnant women are more susceptible to developing serious diseases during COVID-19 than their non-pregnant peers. Pregnant women often express doubt about accepting the vaccination, especially in regard to their security and safety. This study aims to investigate the appreciation of the vaccination offer, and if there are any determinants impacting vaccine hesitancy. A questionnaire was administered to a sample of pregnant women who had just received their immunization against COVID-19 at the vaccination service of a teaching hospital in Rome, from October 2021 to March 2022. A high appreciation of the vaccination services was found, both for the logistic organization and the healthcare personnel, with mean scores above 4 out of 5. The degree of pre-vaccinal doubt was low (41%) or medium (48%) for the largest part of the sample, while the degree of COVID-19 vaccine knowledge was high for 91% of the participants. Physicians were the most decisive information source for the vaccination choice. Our results highlighted that a supportive approach could increase appreciation and improve the setting of vaccinations. Healthcare professionals should aim for a more comprehensive and integrated role of all figures.
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- 2023
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38. How Can Climate Change Anxiety Induce Both Pro-Environmental Behaviours and Eco-Paralysis? The Mediating Role of General Self-Efficacy
- Author
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Matteo Innocenti, Gabriele Santarelli, Gaia Surya Lombardi, Lorenzo Ciabini, Doris Zjalic, Mattia Di Russo, and Chiara Cadeddu
- Subjects
eco-anxiety ,climate change ,eco-paralysis ,Health, Toxicology and Mutagenesis ,Public Health, Environmental and Occupational Health ,adaptation ,Settore MED/42 - IGIENE GENERALE E APPLICATA ,self-efficacy ,mental health - Abstract
While it has been shown that climate change anxiety (emotional distress response to climate change) can enhance pro-environmental behaviours (PEBs) in some subjects, in others it can induce eco-paralysis, thus leading individuals to avoid any form of engagement in actions against climate change. This study aims to clarify which factors influence the relationship between climate change anxiety and the disposition to PEBs, focusing on the role of self-efficacy as a mediating factor. A cross-sectional study was conducted on 394 healthy subjects living in Italy who completed the Pro-Environmental Behaviours Scale (PEBS), the General Self-Efficacy scale (GSE), and the Climate Change Anxiety Scale (CCAS). As a result, the mediation model showed a positive direct effect of the cognitive impairment subscale of CCAS on PEBS and an indirect negative effect of the cognitive impairment subscale of CCAS on PEBS mediated by GSE. These findings show that climate change anxiety has simultaneously two different effects on individuals: it directly encourages PEBs, and indirectly may have detrimental effects on PEBs such as eco-paralysis. Consequently, therapeutic approaches to treat climate change anxiety should not be aimed at rationalising irrational thoughts but rather at helping patients develop coping strategies such as PEBs which, in turn, foster self-efficacy.
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- 2023
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39. Clinical and organizational impact of the use of different cardiac troponin assays for the diagnosis of myocardial infarction without persistent elevation of the ST segment at presentation (NSTEMI) in 12 Italian emergency departments (EDs): the TROCAR study
- Author
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Laura Camoni, Maria Elena Tosti, Angelo Maria Pezzullo, Marco Marchetti, and Chiara Cadeddu
- Subjects
High-sensitivity assays ,Myocardial injury ,Emergency Medicine ,Internal Medicine ,Acute chest pain ,Differential diagnosis ,Acute coronary syndrome ,Clinical practice ,Settore MED/42 - IGIENE GENERALE E APPLICATA - Published
- 2023
40. The added value of applying a disinvestment approach to the process of health technology assessment in Italy
- Author
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Chiara Cadeddu, Luca Regazzi, Eugenio Di Brino, Michele Basile, Fidelia Cascini, Andrea Paladini, Filippo Rumi, Americo Cicchetti, and Walter Ricciardi
- Subjects
Health Policy - Abstract
Objectives The objective of the present policy analysis was to understand how a disinvestment approach to the process of health technology assessment (HTA), applied to the field of medical devices, might help Italian policymakers to properly spend the resources in healthcare. Methods Previous international and national experiences in disinvestment for medical devices were reviewed. Precious insights for the rational expenditure of the resources were derived by assessing the evidence available. Results The disinvestment of ineffective or inappropriate technologies or interventions with an inadequate value-for-money ratio has become a growing priority for National Health Systems. Different international disinvestment experiences of medical devices were identified and described through a rapid review. Although most of them have a strong theoretical framework, their practical application remains difficult. In Italy, there are no examples of large and complex HTA-based disinvestment practices, but their importance is becoming increasingly acknowledged, especially given the need to prioritize the funds provided by Recovery and Resilience Plan. Conclusions Anchoring decisions on health technologies without reassessing the current technological landscape through a robust HTA model might expose to the risk of not ensuring the best employment of the resources available. Thus, it is necessary to develop a strong HTA ecosystem in Italy through adequate consultation with stakeholders to enable a data-driven and evidence-based prioritization of resources toward choices characterized by high value for both patients and society as a whole.
- Published
- 2023
41. Understanding the determinants of vaccine hesitancy and vaccine confidence among adolescents: a systematic review
- Author
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Rosaria Messina, M Sapienza, Teresa Eleonora Lanza, Chiara de Waure, Manuela Chiavarini, Carolina Castagna, Walter Ricciardi, and Chiara Cadeddu
- Subjects
Parents ,Health Knowledge, Attitudes, Practice ,medicine.medical_specialty ,Adolescent ,media_common.quotation_subject ,Immunology ,Scopus ,Reviews ,Scientific literature ,Adolescents ,immunization ,Qualitative analysis ,Promotion (rank) ,vaccine ,medicine ,Humans ,Immunology and Allergy ,Settore MED/42 - IGIENE GENERALE E APPLICATA ,media_common ,hpv ,Pharmacology ,Vaccines ,attitudes ,students ,teenagers ,Quality assessment ,business.industry ,Public health ,Patient Acceptance of Health Care ,vaccination ,Vaccination ,Cross-Sectional Studies ,Family medicine ,Positive relationship ,hesitancy ,Vaccination Hesitancy ,confidence ,business - Abstract
Vaccine hesitancy (VH) in the age of adolescence is a major public health issue, though it has not been widely examined in the scientific literature. This systematic review aims to address the determinants of VH among adolescents aged 10–19. PubMed, Scopus, and Web of Science were searched from the inception until 11 December 2020. Articles in English, assessing adolescents’ attitudes toward vaccination in terms of hesitancy and/or confidence were considered eligible. Out of 14,704 articles, 20 studies were included in the qualitative analysis. Quality assessment was performed through the Appraisal tool for Cross-Sectional Studies (AXIS). A better knowledge of vaccine-preventable diseases, a higher confidence in vaccines, as well as an active involvement in the decision-making process showed a positive relationship with adolescents’ vaccine uptake. These aspects should be considered to plan tailored interventions for the promotion of vaccination among adolescents and to reduce VH. Major limitations of this review are represented by the high heterogeneity of the tools used in the primary studies and the lack of standardization in outcomes definitions. Future research is needed to disentangle the interrelationship among the different determinants of VH in this age group.
- Published
- 2021
42. 'Integrating China in the International Consortium for Personalized Medicine': The Coordination and Support Action to Foster Collaboration in Personalized Medicine Development between Europe and China
- Author
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Chiuhui Mary Wang, Svetlana Klessova, Ilda Hoxhaj, Antonio Giulio de Belvis, Carolina Castagna, Michele Sassano, Stefania Boccia, Walter Ricciardi, Alisha Morsella, Lili Wang, and Chiara Cadeddu
- Subjects
China ,Leverage (negotiation) ,Political science ,Humans ,media_common.cataloged_instance ,European Union ,Precision Medicine ,European union ,Settore MED/42 - IGIENE GENERALE E APPLICATA ,Genetics (clinical) ,media_common ,Horizon 2020 ,Public health ,business.industry ,Public Health, Environmental and Occupational Health ,Public relations ,Personalized medicine ,Knowledge sharing ,Europe ,Work (electrical) ,Genetic/genomic tools ,Sustainability ,business ,Working group ,Delivery of Health Care - Abstract
“Integrating China in the International Consortium for Personalized Medicine” (IC2PerMed) is a coordination and support action funded within the Horizon 2020 work program. Following the guidance of the International Consortium for Personalized Medicine (ICPerMed), the project’s overarching aim is to align the European Union and China’s research agendas in the field of personalized medicine (PM) to enable a swift development of PM approaches in the EU with strong leverage upon EU-Chinese collaboration. Living in the COVID-19 era, we are witnessing how the challenges imposed by the pandemic all around the globe have been acting as a catalyst for collaborations and knowledge sharing among national health systems worldwide. Given the strong interest on behalf of both Europe and China in the advancement of PM approaches, now more than ever, a cross-border collaboration between the 2 powers can accelerate the effective translation of such innovation to healthcare systems, advance research, and ensure that such change follows the directions toward the path of sustainability. IC2PerMed developments will be led by European and Chinese experts equally assembled into 3 Working Groups: (1) people and organization, (2) innovation and market, and (3) research and clinical studies in PM. This complex and dynamic network of actions thrives on dialog, cooperation, and alignment of research at national and global levels; work in the direction taken by IC2PerMed shall pave the way toward the realization of PM’s full potential, prevent it from becoming a burden for healthcare systems, and, rather, prove that it provides an essential and irreplaceable contribution to their effectiveness, efficiency, and sustainability.
- Published
- 2021
43. The Determinants of Vaccine Literacy in the Italian Population: Results from the Health Literacy Survey 2019
- Author
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Chiara Cadeddu, Luca Regazzi, Guglielmo Bonaccorsi, Aldo Rosano, Brigid Unim, Robert Griebler, Thomas Link, Paola De Castro, Roberto D’Elia, Valeria Mastrilli, and Luigi Palmieri
- Subjects
Adult ,Practice ,Health Knowledge, Attitudes, Practice ,Vaccines ,attitudes ,health promotion ,Health, Toxicology and Mutagenesis ,Health Knowledge ,Vaccination ,Public Health, Environmental and Occupational Health ,vaccination hesitancy ,COVID-19 ,Health Literacy ,Cross-Sectional Studies ,Italy ,information-seeking behavior ,health literacy ,vaccination ,health knowledge ,practice ,surveys and questionnaires ,Surveys and Questionnaires ,Humans ,Settore MED/42 - IGIENE GENERALE E APPLICATA ,Pandemics - Abstract
Vaccines are among the most important public health achievements of the last century; however, vaccine awareness and uptake still face significant challenges and the COVID-19 pandemic has only exacerbated this phenomenon. Vaccine Literacy (VL) is the ability to find, understand and judge immunisation-related information to make appropriate immunisation decisions. A cross-sectional study on a sample of 3500 participants, representative of the Italian adult population aged 18+ years, was conducted in Italy in 2021. A validated questionnaire, including sections on health literacy (HL), sociodemographic characteristics, risk factors, and lifestyles of respondents, was used. VL was measured by four items (item 19, 22, 26 and 29) of the HL section. While 67.6% of the respondents had a “good” (47.5%) or “sufficient” (20.1%) level of VL, 32.4% had “limited” VL levels. Although the overall VL level was quite high, many participants reported difficulties in dealing with vaccination information, particularly those with a lower educational level, those living in southern and insular regions of Italy, those with greater financial deprivation and those with a migration background. Improving VL in Italy should be a top priority in the political agenda, with special regard to socially and geographically disadvantaged communities.
- Published
- 2022
44. Coronavirus-Related Health Literacy: A Cross-Sectional Study during the COVID-19 Pandemic in Italy
- Author
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Aldo Rosano, Chiara Lorini, Brigid Unim, Robert Griebler, Chiara Cadeddu, Luca Regazzi, Daniela Galeone, and Luigi Palmieri
- Subjects
Adult ,Attitudes and practices ,COVID-19 ,Health literacy ,Italy ,Knowledge ,Risk factors ,Risk perception ,knowledge ,SARS-CoV-2 ,Health, Toxicology and Mutagenesis ,Public Health, Environmental and Occupational Health ,attitudes and practices ,Health Literacy ,health literacy ,risk perception ,risk factors ,Cross-Sectional Studies ,Humans ,Settore MED/42 - IGIENE GENERALE E APPLICATA ,Pandemics - Abstract
The COVID-19 pandemic has caused an overabundance of valid and invalid information to spread rapidly via traditional media as well as by internet and digital communication. Health literacy (HL) is the ability to access, understand, appraise, and apply health information, making it fundamental for finding, interpreting, and correctly using COVID-19 information. A cross-sectional study of a sample of 3500 participants representative of the Italian adult population aged 18+ years was conducted in Italy in 2021. A validated HL questionnaire was employed, including sections on coronavirus-related HL, general HL, sociodemographic characteristics, risk factors, and respondents’ lifestyle. Of our sample, 49.3% had “excellent” levels of coronavirus-related HL and 50.7% had “sufficient” (20.7%) or “limited” (30.0%) levels. Although the overall HL-COVID level was high, many participants reported difficulties dealing with COVID-19 information; in particular, participants older than 65 years, with a low education level, living in southern regions of Italy, and with high financial deprivation. Targeted public information campaigns and the promotion of HL are required for better navigation of health information environments. The COVID-19 pandemic has highlighted the need to improve HL and to prepare the general population for future emergency and non-emergency situations, confirming that HL can be considered a social vaccine.
- Published
- 2022
45. The role of HTA in COVID-19 vaccination campaign: the Italian experience
- Author
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Chiara Cadeddu and Walter Ricciardi
- Subjects
Strategic planning ,business.industry ,Public Health, Environmental and Occupational Health ,Health technology ,Distribution (economics) ,Public relations ,Social issues ,Vaccination ,Procurement ,3.H. Workshop: The role of HTA for COVID-19 vaccines: present and future perspectives ,Multidisciplinary approach ,Pandemic ,AcademicSubjects/MED00860 ,AcademicSubjects/SOC01210 ,Business ,AcademicSubjects/SOC02610 ,Parallel Programme - Abstract
Issue/problem Italy was one of the four European countries that started to join forces to accelerate access and distribution of a much-needed vaccine against COVID-19. When the first vaccine was approved, a National Strategic Plan for COVID-19 vaccination, examining the most relevant domains for Health Technology Assessment (HTA), has just been issued in Italy. Description of the problem Considering the possible provision of COVID-19 vaccines in the short time, in Autumn 2020 the necessity for a comprehensive assessment came up. In Italy HTA has been identified as the method for assessing the broad value of existing and new vaccines by the last two National Immunization Plans. However, the pandemic highlighted the need for a quick introduction and distribution of COVID-19 vaccines. A multidisciplinary Steering Group was therefore appointed by the Ministry of Health, in order to define vaccination strategies, organizational models, economic aspects, communication and social issues. Results Taking into account plans already released by other countries, a National Strategic Plan for COVID-19 vaccination was issued in December 2020. Main topics covered were: epidemiology and priority groups to be immunized, logistic and organization, efficacy and safety monitoring, economic and burden of disease assessments, communication. The application of these recommendations has finally proven to be difficult, because of vaccines procurement delays, suspected adverse events, inequalities in the different Regional settings. Lessons Given the concerns and difficulties faced by Italy and other European countries in the appraisal and management of COVID-19 vaccines, a HTA adapted framework could be an option for guiding the definition of National Strategic Plans. This could offer a common structured approach, make decision-making process more transparent, and be significant for a timely, convenient, and affordable access to new vaccines against SARS-CoV-2.
- Published
- 2021
46. Health Technology Assessment for COVID19: an approach for the Horizon Scanning of health innovations
- Author
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Matteo Ruggeri, Chiara Cadeddu, Marco Marchetti, D. Mandolini, P. Roazzi, and M. Grigioni
- Subjects
Computer science ,Complexity theory and organizations ,Judgement ,Public Health, Environmental and Occupational Health ,Health technology ,Multiple-criteria decision analysis ,Risk analysis (engineering) ,Multidisciplinary approach ,DM: Health assessments: impact, technology ,Scatter plot ,Objective approach ,AcademicSubjects/MED00860 ,AcademicSubjects/SOC01210 ,Poster Sessions ,AcademicSubjects/SOC02610 ,Decision analysis - Abstract
Background The COVID-19 pandemic definitely changed the approach to technologies evaluation, firstly in terms of timeliness. In order to answer to this need, a new methodology was proposed, joining the elements of horizon scanning with the Multi-Criteria Decision Analysis (MCDA). In this work we describe the results of 2 case studies of application. Methods By means of an assessment matrix, a multidisciplinary expert panel gave a score based on a Likert scale and related to potential value and perceived risk for each technology. Economic, clinical and ethical criteria were considered as a summary of Health Technology Assessment (HTA) main domains. The final scores were then weighted by the MCDA and a scatter plot defined 4 positioning scenarios according to the balance of values and risks resulted, each conducting to an appropriate recommendation (full HTA report or reject). A Monte Carlo simulation was also carried out for the assessment of variability of results. Results An individual protection device for COVID-19 and a contact tracing app were assessed. The first technology was placed in the “Danger Zone” of the graph, because of its high costs and organizational complexity. The second one was placed in the “Comfort Zone” of the graph, due to low costs and easiness of implementation and management. For this innovation a recommendation for a full HTA and a pilot testing was given. In both cases, the Monte Carlo simulation confirmed the results of previous analyses. Conclusions The implementation of this new tool presented for the large amount of innovations created in response to COVID-19 could be supportive for decision makers, especially in pandemic times when a rapid answer is necessary. Improvements in the subjective judgement process, by introducing an objective approach, is now ongoing as it could enhance the strength of the final decision. Key messages In a pandemic time as the current, HTA should be as rapid as possible without losing scientific robustness. The methodology described could be an answer in support to the decision-making process, allowing an adequate and quick priority setting.
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- 2021
47. Italian health workers’ knowledge, attitudes and behaviours towards COVID-19 vaccination
- Author
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Walter Ricciardi, A. Lontano, Patrizia Laurenti, E. Marziali, R. Messina, A. Paladini, Giovanna Elisa Calabrò, S. Boccia, L. Regazzi, and Chiara Cadeddu
- Subjects
2019-20 coronavirus outbreak ,education.field_of_study ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Population ,Public Health, Environmental and Occupational Health ,Sample (statistics) ,Vaccination ,Environmental health ,Health care ,AcademicSubjects/MED00860 ,AcademicSubjects/SOC01210 ,Lack of knowledge ,Poster Sessions ,Social determinants of health ,DR: Infectious diseases, preparedness and vaccines ,business ,Psychology ,education ,AcademicSubjects/SOC02610 - Abstract
Background Vaccine hesitancy is the reluctance or refusal to be vaccinated. While it has been widely studied for various contagious diseases, there is still a lack of knowledge about this phenomenon for COVID-19, especially if health workers' hesitancy is considered. Methods An extensive review of the literature was conducted to identify the main determinants of vaccine hesitancy in health workers, as well as to find already validated surveys to evaluate the knowledge, attitudes and behaviors (KAB) of health workers towards vaccination, both in general and with specific regard to COVID-19. Building on the available information, a new survey was developed to assess the KAB of Italian health care workers towards COVID-19 vaccination after validation with a pilot study in a diverse sample of 30 Italian health workers. Results A new survey was validated to assess the KAB of health workers towards COVID-19 vaccination in Italian health workers. The survey requires about 6 minutes to complete and is composed of 30 questions, investigating different domains: socio-demographic and professional characteristics (6); health status (2); attitudes (11); behaviors (6); knowledge (4). The survey will be administered to a representative sample of at least 385 Italian health workers through the web platform SurveyMonkey in the period June-September 2021. Preliminary results will be available by the end of October 2021. Conclusions By analyzing KAB towards COVID-19 vaccination with a new tool, the magnitude and determinants of health worker's COVID-19 vaccine hesitancy will be evaluated to understand how to improve health workers' perception towards COVID-19 vaccination and, consequently, foster their positive influence on the general population. Key messages We explore the knowledge, attitudes and behaviors towards COVID-19 vaccination in all categories of health workers operating on the Italian territory to understand the reasons of vaccine hesitancy. Understanding the determinants of COVID-19 vaccine hesitancy in Italian health workers is necessary given their influence on the perception of the general population in Italy.
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- 2021
48. Vaccine market access pathways in the EU27 and the United Kingdom-analysis and recommendations for improvements
- Author
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Mira Pavlovic, Anna Kapusniak, Valérie Laigle, Chiara Cadeddu, E. Beck, Mondher Toumi, Maarten J. Postma, Value, Affordability and Sustainability (VALUE), Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), and Microbes in Health and Disease (MHD)
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Market Access ,Market access ,law.invention ,Procurement ,law ,media_common.cataloged_instance ,Humans ,European Union ,European union ,Settore MED/42 - IGIENE GENERALE E APPLICATA ,License ,Pandemics ,Health policy ,Ecosystem ,media_common ,Vaccines ,General Veterinary ,General Immunology and Microbiology ,business.industry ,Immunization Programs ,SARS-CoV-2 ,Health Policy ,Public Health, Environmental and Occupational Health ,Health technology ,COVID-19 ,Public relations ,United Kingdom ,Policy ,Infectious Diseases ,Transparency (graphic) ,CLARITY ,Molecular Medicine ,business ,Vaccine - Abstract
Background: Vaccine market access (VMA) pathways across the European Union (EU) and the United Kingdom (UK) are complex, lengthy, and heterogeneous, particularly when compared with pharmaceuticals. The knowledge base to inform recommendations for optimization of VMA is lacking. We therefore conducted a comprehensive evaluation of EU VMA pathways. Methods: Research in two phases included: (1) mapping VMA pathways in each EU member state (including the UK) based on a literature review, expert interviews, and mathematical archetyping; and (2) interviews with vaccine experts to identify barriers, drivers, and recommendations for regional VMA alignments. Results: Key steps in VMA across the EU include horizon scanning, early advice, National Immunization Technical Advisory Group (NITAG) recommendation for inclusion in national immunization programs, health technology assessment (HTA), final decision and procurement. We found significant complexity and heterogeneity, particularly for early advice, and in the roles, decision-making criteria, and transparency of NITAGs and HTA bodies. The most important drivers for rapid VMA included demonstration of disease burden and vaccine benefit (e.g., efficacy, safety, economic). Key barriers were budget limitations and complexity/clarity of VMA processes (e.g., need for national-regional consensus, clarity on process initiation, and clarity on the role of HTA). Recommendations for alignment at EU and member-state levels include information sharing, joint clinical assessment, initiatives to address funding and political barriers, and improved transparency by decision-making bodies. Early engagement with vaccine stakeholders was a key recommendation for manufacturers. Conclusions: There is significant potential for alignment, collaboration, and improvement of VMA across the EU. Roles, responsibilities, and transparency of key bodies can be clarified. The COVID-19 pandemic response should stimulate policies to improve access to all vaccines, including routine ones, and form the foundation upon which a consistent vaccine ecosystem can be created for the EU, one that is resilient, consistent between member states, and fit for purpose. (c) 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).
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- 2021
49. Programmazione sanitaria a livello di azienda: gli strumenti della programmazione e del controllo operativo.
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Damiani G, Specchia ML, Ricciardi W, Damiani, Gianfranco, Cadeddu, Chiara, Ricciardi, Walter, gianfranco damiani (ORCID:0000-0003-3028-6188), chiara cadeddu (ORCID:0000-0003-0149-1078), walter ricciardi (ORCID:0000-0002-5655-688X), Damiani G, Specchia ML, Ricciardi W, Damiani, Gianfranco, Cadeddu, Chiara, Ricciardi, Walter, gianfranco damiani (ORCID:0000-0003-3028-6188), chiara cadeddu (ORCID:0000-0003-0149-1078), and walter ricciardi (ORCID:0000-0002-5655-688X)
- Abstract
La sostenibilità rappresenta per i sistemi sanitari di tutto il mondo una delle maggiori sfide. Questo tema, già centrale nell’esercizio della tutela della salute in un’epoca di crescenti pressioni economiche, aumentoincontrollato della domanda di salute, legato ai trend demografici ed epidemiologici, aspettative crescenti da parte dei pazienti e innovazione tecnologica, è divenuto ancora più dominante a seguito della grave emergenza sanitaria su scala globale determinata dalla pandemia da SARS-Cov-2. Il perseguimento di obiettivi di efficacia assistenziale e, nel contempo, di appropriatezza clinica ed organizzativa ed efficienza nell’allocazione e nell’utilizzo delle risorse richiede quale priorità strategica la diffusione del linguaggio, delle logiche e degli strumenti della Programmazione e dell’Organizzazione sanitaria.
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- 2021
50. Sanità Pubblica: scienza e politica per la salute dei cittadini.
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Ricciardi, Walter, Cadeddu, Chiara, Calabro', Giovanna Elisa, Cascini, Fidelia, Walter Ricciardi (ORCID:0000-0002-5655-688X), Chiara Cadeddu (ORCID:0000-0003-0149-1078), Giovanna Elisa Calabrò (ORCID:0000-0003-0259-3797), Fidelia Cascini (ORCID:0000-0001-6499-0734), Ricciardi, Walter, Cadeddu, Chiara, Calabro', Giovanna Elisa, Cascini, Fidelia, Walter Ricciardi (ORCID:0000-0002-5655-688X), Chiara Cadeddu (ORCID:0000-0003-0149-1078), Giovanna Elisa Calabrò (ORCID:0000-0003-0259-3797), and Fidelia Cascini (ORCID:0000-0001-6499-0734)
- Abstract
Gli esperti di sanità pubblica non parlano per avere ragione dopo, studiano per affrontare condizioni critiche per la salute dei cittadini e organizzare al meglio le strutture che devono affrontarle. Su questa divaricazione pesano due elementi decisivi: il rapporto tra scienza e politica e l’esistenza di un sistema socio-sanitario pubblico. Oggi viviamo la crisi più grave dalla seconda guerra mondiale e, in ogni crisi, i leader hanno due responsabilità ugualmente importanti: risolvere il problema immediato e impedire che si ripeta. La pandemia di Covid-19 ne è un esempio. Dobbiamo salvare vite umane ora migliorando al contempo il modo in cui rispondiamo alle epidemie in generale. Il primo punto è più urgente, ma il secondo ha conseguenze cruciali a lungo termine. Per quanto riguarda la sanità, non vi è alcun dubbio che alcuni elementi alimentino o danneggino la salute e che l’intervento pubblico è indispensabile e decisivo. Michael Marmot li ha riassunti in 6 categorie: condizioni legate alla nascita e alla prima infanzia, istruzione, lavoro, condizioni sociali degli anziani, una serie di elementi comunitari come trasporto, alloggio, sicurezza e, trasversalmente, ciò che egli chiama "equità", che equivale a una ridistribuzione sufficiente della ricchezza e del reddito per garantire la sicurezza sociale ed economica delle popolazioni. Questi elementi sono alla base della nostra Costituzione e, seppur con alterne vicende e differente efficacia la maggior parte dei Governi italiani ha cercato finora di garantirli, ma a maggior ragione questo dovrà valere per il futuro e nel libro si analizzeranno i principi e i metodi attraverso cui garantire al nostro Paese una “prospera normalità”.
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- 2021
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