53,542 results on '"Chiara, C."'
Search Results
2. The potential of baicalin to enhance neuroprotection and mitochondrial function in a human neuronal cell model
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Liu, Zoe S. J., Truong, Trang T. T., Bortolasci, Chiara C., Spolding, Briana, Panizzutti, Bruna, Swinton, Courtney, Kim, Jee Hyun, Hernández, Damián, Kidnapillai, Srisaiyini, Gray, Laura, Berk, Michael, Dean, Olivia M., and Walder, Ken
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- 2024
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3. Isomer depletion
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Carroll, J. J. and Chiara, C. J.
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- 2024
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4. Low spin spectroscopy of neutron-rich 43,44,45Cl via {\beta} and (\beta}n decay
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Tripathi, V., Bhattacharya, S., Rubino, E., Benetti, C., Perello, J. F., Tabor, S. L., Liddick, S. N., Bender, P. C., Carpenter, M. P., Carroll, J. J., Chester, A., Chiara, C. J., Childers, K., Clark, B. R., Crider, B. P., Harke, J. T., Jain, R., Longfellow, B., Luitel, S., Mogannam, M., Ogunbeku, T. H., Richard, A. L., Saha, S., Shimizu, N., Shehu, O. A., Utsuno, Y., Unz, R., Xiao, Y., Yoshida, S., and Zhu, Yiyi
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Nuclear Experiment - Abstract
{\beta} decay of neutron-rich isotopes 43,45 S,studied at the National Superconducting Cyclotron Laboratory is reported here. {\beta} delayed {\gamma} transitions were detected by an array of 16 clover detectors surrounding the Beta Counting Station which consists of a 40x40 Double Sided Silicon Strip Detector followed by a Single Sided Silicon Strip Detector. {\beta} decay half-lives have been extracted for 43,45 S by correlating implants and decays in the pixelated implant detector with further coincidence with {\gamma} transitions in the daughter nucleus. The level structure of 43,45 Cl is expanded by the addition of 20 new {\gamma} transitions in 43Cl and 8 in 45 Cl with the observation of core excited negative-parity states for the first time. For 45 S decay, a large fraction of the {\beta} decay strength goes to delayed neutron emission populating states in 44 Cl which are also presented. Comparison of experimental observations is made to detailed shell-model calculations using the SDPFSDG-MU interaction to highlight the role of the diminished N = 28 neutron shell gap and the near degeneracy of the proton s 1/2 and d 3/2 orbitals on the structure of the neutron-rich Cl isotopes. The current work also provides further support to a ground state spin-parity assignment of 3/2 + in 45 Cl.
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- 2023
5. $\beta^-$ decay of neutron-rich $^{45}$Cl at magic number N=28
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Bhattacharya, Soumik, Tripathi, Vandana, Tabor, S. L., Volya, A., Bender, P. C., Benetti, C., Carpenter, M. P., Carroll, J. J., Chester, A., Chiara, C. J., Childers, K., Clark, B. R., Crider, B. P., Harke, J. T., Liddick, S. N., Lubna, R. S., Luitel, S., Longfellow, B., Mogannam, M. J., Ogunbeku, T. H., Perello, J., Richard, A. L., Rubino, E., Saha, S., Shehu, O. A., Unz, R., Xiao, Y., and Zhu, Yiyi
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Nuclear Experiment - Abstract
Results from the study of $\beta^-$-decay of $^{45}$Cl, produced in the fragmentation of a 140-MeV/u $^{48}$Ca beam, are presented. The half-life for $^{45}$Cl $\beta$-decay is measured to be 513(36) ms. The $\beta^-$ and $\beta^- 1n$ decay of $^{45}$Cl populated excited states in $^{45,44}$Ar, respectively. On the basis of $\gamma$-ray singles and $\gamma$-$\gamma$ coincidence data, decay schemes for the two daughter nuclei have been established. They are compared with shell model calculations using the FSU interaction. The low-lying negative parity states for $^{45}$Ar are well described by a single particle (neutron) occupying orbitals near the Fermi surface, whereas neutron excitations across the $N = 20$ shell gap are needed to explain the positive-parity states which are expected to be populated in allowed Gamow-Teller $\beta$-decay of $^{45}$Cl. The highest $\beta$-feeding to the 5/2$^+$ state in $^{45}$Ar from the ground state of $^{45}$Cl points towards a 3/2$^+$ spin-parity assignment of the ground state of the parent over the other possibility of 1/2$^+$. The high Q$_{\beta^-}$ value of $^{45}$Cl decay allows for the population of $1p1h$ states above the neutron separation energy in $^{45}$Ar leading to positive parity states of $^{44}$Ar being populated by removal of one neutron from the $sd$ shell. The spin-parities of the excited levels in $^{44}$Ar are tentatively assigned for the first time by comparison with the shell model calculations. The 2978~keV level of $^{44}$Ar is identified as the excited 0$^+$ level which could correspond to a different configuration from the ground state., Comment: 11 pages, 10 figures
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- 2023
6. Executive Summary of the Topical Program: Nuclear Isomers in the Era of FRIB
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Misch, G. W., Mumpower, M. R., Kondev, F. G., Marley, S. T., Almaraz-Calderon, S., Brodeur, M., Brown, B. A., Carpenter, M. P., Carroll, J. J., Chiara, C. J., Chipps, K. A., Crider, B. P., Gade, A., Grzywacz, R., Jones, K. L., Kay, B. P., Kolos, K., Litvinov, Yu. A., Lopez-Caceres, S., Meyer, B. S., Minamisono, K., Morgan, G. E., Orford, R., Pain, S. D., Purcell, J., Ratkiewicz, A., Schatz, H., Sprouse, T. M., Sun, Y., Surman, R., Tannous, J. A., and Walker, P. M.
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Nuclear Theory ,Nuclear Experiment - Abstract
We report on the Facility for Rare Isotope Beams (FRIB) Theory Alliance topical program "Nuclear Isomers in the Era of FRIB". We outline the many ways isomers influence and contribute to nuclear science and technology, especially in the four FRIB pillars: properties of rare isotopes, nuclear astrophysics, fundamental symmetries, and applications for the nation and society. We conclude with a resolution stating our recommendation that the nuclear physics community actively pursue isomer research. A white paper is forthcoming., Comment: 4 pages including references
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- 2023
7. Instructional Coordination for Response to Intervention: How Organizational Contexts Shape Tier 2 Interventions in Practice
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Miesner, Helen Rose, Blair, Elizabeth E., Packard, Chiara C., Macgregor, Lyn, and Grodsky, Eric
- Abstract
Purpose: This study examines how resources and organizational decisions within seven geographically diverse elementary schools shape instructional coordination for Tier 2 interventions within the Response to Intervention (RtI) framework. Research Methods: This work is part of a larger, multiple-case study examining how schools support academic achievement for economically disadvantaged students. We draw on qualitative interview and observation data from seven purposively sampled public elementary schools in Wisconsin during the 2017-18 school year. In our analysis, we approach each school as an individual case to ascertain how resources and organizational decisions shaped instructional coordination for Tier 2 interventions within the RtI framework. Findings: We find that organizational contexts shape how schools approach the instructional coordination of staffing and schedules requisite for multitiered instruction. Specifically, local programming, delineation of staff roles, and availability and deployment of school resources influenced if and how schools coordinated staff and schedules to support RtI. These elements consequently informed student groupings for interventions, the extent of student access to Tier 1 and Tier 2 content, and staff engagement in data-driven discussions. Implications: By closely examining the everyday realities of diverse elementary schools, this study demonstrates that RtI is not a singular program but a context-contingent process. In tracing the relationships between school contexts, instructional coordination, and the practical implementation of RtI, we provide insight into the messy realities of schools and obstacles to RtI that past research overlooks. These findings emphasize the importance of systematic, school-wide coordination that extends beyond single grade levels and subjects.
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- 2023
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8. Metergoline Shares Properties with Atypical Antipsychotic Drugs Identified by Gene Expression Signature Screen
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Bortolasci, Chiara C, Jaehne, Emily J, Hernández, Damián, Spolding, Briana, Connor, Timothy, Panizzutti, Bruna, Dean, Olivia M, Crowley, Tamsyn M, Yung, Alison R, Gray, Laura, Kim, Jee Hyun, van den Buuse, Maarten, Berk, Michael, and Walder, Ken
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- 2023
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9. $^{57}$Zn $\beta$-delayed proton emission establishes the $^{56}$Ni $rp$-process waiting point bypass
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Saxena, M., Ong, W. -J, Meisel, Z., Hoff, D. E. M., Smirnova, N., Bender, P. C., Burcher, S. P., Carpenter, M. P., Carroll, J. J., Chester, A., Chiara, C. J., Conaway, R., Copp, P. A., Crider, B. P., Derkin, J., Estrade, A., Hamad, G., Harke, J. T., Jain, R., Jayatissa, H., Liddick, S. N., Longfellow, B., Mogannam, M., Montes, F., Nepal, N., Ogunbeku, T. H., Richard, A. L., Schatz, H., Soltesz, D., Subedi, S. K., Sultana, I., Tamashiro, A. S., Tripathi, V., Xiaog, Y., and Zink, R.
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Nuclear Experiment ,Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Solar and Stellar Astrophysics - Abstract
We measured the $^{57}$Zn $\beta$-delayed proton ($\beta$p) and $\gamma$ emission at the National Superconducting Cyclotron Laboratory. We find a $^{57}$Zn half-life of 43.6 $\pm$ 0.2 ms, $\beta$p branching ratio of (84.7 $\pm$ 1.4)%, and identify four transitions corresponding to the exotic $\beta$-$\gamma$-$p$ decay mode, the second such identification in the $f p$-shell. The $p/\gamma$ ratio was used to correct for isospin mixing while determining the $^{57}$Zn mass via the isobaric multiplet mass equation. Previously, it was uncertain as to whether the rp-process flow could bypass the textbook waiting point $^{56}$Ni for astrophysical conditions relevant to Type-I X-ray bursts. Our results definitively establish the existence of the $^{56}$Ni bypass, with 14-17% of the $rp$-process flow taking this route.
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- 2022
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10. Shapes, Softness and Non-Yrast Collectivity in 186W
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Prasher, V. S., Mitchell, A. J., Lister, C. J., Chowdhury, P., Afanasieva, L., Albers, M., Chiara, C. J., Carpenter, M. P., Cline, D., D'Olympia, N., Guess, C. J., Hayes, A. B., Hoffman, C. R., Janssens, R. V. F., Kay, B. P., Khoo, T. L., Korichi, A., Lauritsen, T., Merchan, E., Qiu, Y., Seweryniak, D., Shearman, R., Tandel, S. K., Verras, A., Wu, C. Y., and Zhu, S.
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Nuclear Experiment ,Nuclear Theory - Abstract
Non-yrast, excited states in neutron-rich $^{186}$W were populated via inelastic-scattering reactions using beams of $^{136}$Xe nuclei accelerated to 725 and 800 MeV. Levels populated in the reactions were investigated via particle-$ \gamma $ coincidence techniques using the Gammasphere array of High-Purity Germanium detectors and the compact heavy-ion counter, CHICO2. The $ K^{\pi} = 2 ^{+} $ ($\gamma$), $ K^{\pi} = 0^{+}$ and $ K^{\pi} = 2^{-} $ (octupole) rotational side bands were extended to spins $ 14\hbar $, $ 12\hbar $, and $ 13\hbar $, respectively. A staggering pattern observed in the energies of levels in the $ K^{\pi} = 2^{+} $ band was found to be consistent with a potential that gets softer to vibration in the $ \gamma $ degree of freedom with increasing spin. The odd-even staggering of states in the $ K^{\pi} = 2^{-}$ band was found to exhibit a phase opposite to that seen in the $ \gamma $ band; an effect most probably associated with Coriolis coupling to other, unobserved octupole vibrational bands in $^{186}$W., Comment: 14 pages, 16 figures
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- 2021
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11. The central role of pathology labs in breast cancer precision oncology: a call for action
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Pruneri, Giancarlo, Lorenzini, Daniele, Mastropasqua, Mauro G., Perrone, Giuseppe, Rizzo, Antonio, Santini, Donatella, Volpi, Chiara C., Cinieri, Saverio, Zambelli, Alberto, Sapino, Anna, and Castellano, Isabella
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- 2023
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12. Collaborating in Context: Relational Trust and Collaborative Structures at Eight Wisconsin Elementary Schools. WCER Working Paper No. 2019-7
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University of Wisconsin-Madison, Wisconsin Center for Education Research (WCER), Miesner, H. Rose, Blair, Elizabeth E., Packard, Chiara C., Velazquez, Maria, Macgregor, Lyn, and Grodsky, Eric
- Abstract
Teacher collaboration is a key factor in improving instructional quality and promoting student achievement. Though research attests to the importance of school contextual elements for the work of teachers, few studies investigate how these factors interact to enable or constrain collaboration. This study examines teacher perspectives on collaborative practices by analyzing observations and interviews of teachers and other staff at eight Wisconsin elementary schools. It finds that structures for collaboration shape teacher participation in collaborative practices. The authors distinguish among three structures of collaboration--requisite, optional, and informal--and explore how relational trust among teachers and between teachers and their administrators and colleagues affects collaboration. They find that teachers who attested to the presence of relational trust within their schools collaborated with colleagues, regardless of formalized times to do so. Conversely, teachers who described a lack of relational trust opted against collaborating with grade-level colleagues, despite, in some instances, having access to collaborative planning time. Instructional approaches influenced collaborative structures and relational trust, as some teaching formats fostered contact between practitioners while others separated teachers. The study concludes by discussing the implications of the findings for extant and future research regarding collaboration in context.
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- 2019
13. Fast-timing study of $^{81}$Ga from the $\beta$ decay of $^{81}$Zn
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Paziy, V., Fraile, L. M., Mach, H., Olaizola, B., Simpson, G. S., Aprahamian, A., Bernards, C., Briz, J. A., Bucher, B., Chiara, C. J., Dlouhý, Z., Gheorghe, I., Ghiţǎ, D., Hoff, P., Jolie, J., Köster, U., Kurcewicz, W., Licǎ, R., Mǎrginean, N., Mǎrginean, R., Régis, J. -M., Rudigier, M., Sava, T., Stǎnoiu, M., Stroe, L., and Walters, W. B.
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Nuclear Experiment ,Nuclear Theory - Abstract
The $\beta^{-}$ decay of $^{81}$Zn to the neutron magic $N=50$ nucleus $^{81}$Ga, with only three valence protons with respect to $^{78}$Ni, was investigated. The study was performed at the ISOLDE facility at CERN by means of $\gamma$ spectroscopy. The $^{81}$Zn half-life was determined to be $T_{1/2}=290(4)$ ms while the $\beta$-delayed neutron emission probability was measured as $P_n=23(4)\%$. The analysis of the $\beta$-gated $\gamma$-ray singles and $\gamma$-$\gamma$ coincidences from the decay of $^{81}$Zn provides 47 new levels and 70 new transitions in $^{81}$Ga. The $\beta^-$$n$ decay of $^{81}$Zn was observed and a new decay scheme into the odd-odd $^{80}$Ga nucleus was established. The half-lives of the first and second excited states of $^{81}$Ga were measured via the fast-timing method using LaBr$_3$(Ce) detectors. The level scheme and transition rates are compared to large-scale shell-model calculations. The low-lying structure of $^{81}$Ga is interpreted in terms of the coupling of the three valence protons outside the doubly-magic $^{78}$Ni core., Comment: Submitted to Phys. Rev. C
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- 2020
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14. Observation of $\gamma$-vibrations and alignments built on non-ground-state configurations in 156Dy
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Majola, S. N. T., Hartley, D. J., Riedinger, L. L., Sharpey-Schafer, J. F., Allmond, J. M., Beausang, C., Carpenter, M. P., Chiara, C. J., Cooper, N., Curien, D., Gall, B. J. P., Garrett, P. E., Janssens, R. V. F., Kondev, F. G., Kulp, W. D., Lauritsen, T., McCutchan, E. A., Miller, D., Piot, J., Redon, N., Riley, M. A., Simpson, J., Stefanescu, I., Werner, V., Wang, X., Wood, J. L., Yu, C. -H., and Zhu, S.
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Nuclear Experiment ,Nuclear Theory - Abstract
The exact nature of the lowest $K^\pi =2_\gamma ^+$ rotational bands in all deformed nuclei remains obscure. Traditionally they are assumed to be collective vibrations of the nuclear shape in the $\gamma$ degree of freedom perpendicular to the nuclear symmetry axis. Very few such $\gamma$-bands have been traced past the usual back-bending rotational alignments of high-j nucleons. We have investigated the structure of positive-parity bands in the N=90 nucleus 156Dy, using the 148Nd(12C,4n)156Dy reaction at 65 MeV, observing the resulting ${\gamma}$-ray transitions with the Gammasphere array. The even- and odd-spin members of the $K^\pi =2_\gamma^+$ $\gamma$-band are observed to 32+ and 31+ respectively. This rotational band faithfully tracks the ground-state configuration to the highest spins. The members of a possible $\gamma$-vibration built on the aligned yrast S-band are observed to spins 28+ and 27+. An even-spin positive-parity band, observed to spin 24+, is a candidate for an aligned S-band built on the seniority-zero configuration of the $0_2^+$ state at 676 keV. The crossing of this band with the $0_2^+$ band is at $\hbar\omega$= 0.28(1) MeV and is consistent with the configuration of the $0_2^+$ band not producing any blocking of the monopole pairing., Comment: Published in Physics Review C
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- 2020
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15. First candidates for {\gamma} vibrational bands built on the [505]11/2- neutron orbital in odd-A Dy isotopes
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Majola, S. N. T., Sithole, M. A., Mdletshe, L., Hartley, D., Timar, J., Nyako, B. M., Allmond, J. M., Bark, R. A., Beausang, C., Bianco, L., Bucher, T. D., Bvumbi, S. P., Carpenter, M. P., Chiara, C. J., Cooper, N., Cullen, D. M., Curien, D., Dinoko, T. S., Gall, B. J. P., Garrett, P. E., Greenlees, P. T., Hirvonen, J., Jakobsson, U., Jones, P. M., Julin, R., Juutinen, S., Ketelhut, S., Kheswa, B. V., Kondev, F. G., Korichi, A., Kulp, W. D., Lauritsen, T., Lawrie, E. A., Makhathini, L., Masiteng, P. L., Maqabuka, B., Mccutchan, E. A., Miller, D., Miller, S., Minkova, A., Msebi, L., Mthembu, S. H., Ndayishimye, J., Nieminen, P., Ngcobo, P. Z., Ntshangase, S. S., Orce, J. N., Peura, P., Rahkila, P., Redon, N., Riedinger, L. L., Riley, M. A., Roux, D. G., Ruotsalainen, P., Piot, J., Saren, J., Sharpey-Schafer, J. F., Scholey, C., Shirinda, O., Simpson, J., Sorri, J., Stefanescu, I., Stolze, S., Uusitalo, J., Wang, X., Werner, V., Wood, J. L., Yu, C. H., Zhu, S., and Zimba, G.
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Nuclear Experiment ,Nuclear Theory - Abstract
Rotational structures have been measured using the Jurogam II and GAMMASPHERE arrays at low spin following the 155Gd({\alpha},2n)157Dy and 148Nd(12C, 5n)155Dy reactions at 25 and 65 MeV, respectively. We report high-K bands, which are conjectured to be the first candidates of a K{\pi}= 2+ {\gamma} vibrational band, built on the [505]11/2- neutron orbital, in both odd-A 155, 157Dy isotopes. The coupling of the first excited K=0+ states or the so-called \b{eta} vibrational bands at 661 and 676 keV in 154Dy and 156Dy to the [505]11/2- orbital, to produce a K{\pi}=11/2- band, was not observed in both 155Dy and 157Dy, respectively. The implication of these findings on the interpretation of the first excited 0+ states in the core nuclei 154Dy and 156Dy are also discussed., Comment: Published in Physical Rev C
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- 2020
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16. Lipopolysaccharide-binding protein and bone health: data from a population-based sample of men
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Cleminson, Jasmine R., Pasco, Julie A., Bortolasci, Chiara C., Holloway-Kew, Kara L., Hodge, Jason M., Anderson, Kara B., Kotowicz, Mark A., Samarasinghe, Rasika M., and Williams, Lana J.
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- 2023
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17. Beta-delayed-neutron studies of $^{135,136}$Sb and $^{140}$I performed with trapped ions
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Alan, B. S., Caldwell, S. A., Scielzo, N. D., Czeszumska, A., Clark, J. A., Savard, G., Aprahamian, A., Burkey, M. T., Chiara, C. J., Harker, J., Levand, A. F., Marley, S. T., Morgan, G. E., Munson, J. M., Norman, E. B., Nystrom, A., Orford, R., Padgett, S. W., Galvan, A. Perez, Sharma, K. S., Siegl, K., and Strauss, S. Y.
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Nuclear Experiment ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Beta-delayed-neutron ($\beta$n) spectroscopy was performed using the Beta-decay Paul Trap and an array of radiation detectors. The $\beta$n branching ratios and energy spectra for $^{135,136}$Sb and $^{140}$I were obtained by measuring the time of flight of recoil ions emerging from the trapped ion cloud. These nuclei are located at the edge of an isotopic region identified as having $\beta$n branching ratios that impact the r-process abundance pattern around the A~130 peak. For $^{135,136}$Sb and $^{140}$I, $\beta$n branching ratios of 14.6(11)%, 17.6(28)%, and 7.6(28)% were determined, respectively. The $\beta$n energy spectra obtained for $^{135}$Sb and $^{140}$I are compared with results from direct neutron measurements, and the $\beta$n energy spectrum for $^{136}$Sb has been measured for the first time.
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- 2019
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18. The central role of pathology labs in breast cancer precision oncology: a call for action
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Giancarlo Pruneri, Daniele Lorenzini, Mauro G. Mastropasqua, Giuseppe Perrone, Antonio Rizzo, Donatella Santini, Chiara C. Volpi, Saverio Cinieri, Alberto Zambelli, Anna Sapino, and Isabella Castellano
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Multigenic tests represent an essential tool for the selection of adjuvant therapy in estrogen-positive/HER2-negative (ER + /HER2-) early breast cancer (BC). The workflow of these tests, either if they are externalized or carried out in-house, generates a workload for the pathology laboratories, that is often underestimated and may affect timely therapy initiation. Here, we describe the evolving role of pathology laboratories in using multigenic tests and, more in general, in providing adequate tissue for molecular analyses. Moreover, we propose a “reflex testing” model, in which pathologists, based on pre-specified and shared criteria, are expected to action multigene testing independently of multidisciplinary team discussion in ER + /HER2- BC patients, in order to optimize turnaround time and proper therapy intervention.
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- 2023
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19. Lymphomas in People Living with HIV
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Emanuela Vaccher, Annunziata Gloghini, Chiara C. Volpi, and Antonino Carbone
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lymphomas ,people living with HIV ,management ,tumor prevention in people living with HIV ,EBV ,KSHV ,Medicine - Abstract
Lymphomas in people living with HIV (PLWH) are associated with Epstein Barr virus (EBV) and Kaposi-sarcoma-associated herpesvirus (KSHV). They include primary effusion lymphoma, large B-cell lymphoma arising in multicentric Castleman disease, plasmablastic lymphoma, Burkitt lymphoma, diffuse large B-cell lymphoma, and Hodgkin lymphoma (HL). Inclusion of these lymphomas in the WHO classification of tumors of hematopoietic and lymphoid tissues and the increasing recognition of these disorders have resulted in established clinical management that has led to improved outcomes. In this review, we report on the current management in lymphomas occurring in PLWH with an emphasis on KSHV-associated disorders and EBV-related HL. We also report on the simultaneous occurrence of KSHV- and EBV-associated disorders and highlight preventive measures that have been planned for tumor prevention in PLWH. In conclusion, it is recommended that treatment choice for PLWH affected by lymphoma, and receiving effective combined antiretroviral therapy (cART), should not be influenced by HIV status. Moreover, there is an urgent need (1) to reduce the current large disparities in health care between HIV-infected and HIV-uninfected populations, (2) to disseminate effective treatment, and (3) to implement preventive strategies for PLWH.
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- 2022
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20. Inflammation and Nitro-oxidative Stress as Drivers of Endocannabinoid System Aberrations in Mood Disorders and Schizophrenia
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Morris, Gerwyn, Sominsky, Luba, Walder, Kenneth R., Berk, Michael, Marx, Wolfgang, Carvalho, André F., Bortolasci, Chiara C., Maes, Michael, and Puri, Basant K.
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- 2022
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21. The role of metformin as a treatment for neuropsychiatric illness
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Dodd, Seetal, Sominsky, Luba, Siskind, Dan, Bortolasci, Chiara C, Carvalho, Andre F., Maes, Michael, Walker, Adam J., Walder, Ken, Yung, Alison R, Williams, Lana J., Myles, Hannah, Watson, Tayler, and Berk, Michael
- Published
- 2022
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22. Collaborating in context: Relational trust and collaborative formats at eight elementary schools
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Miesner, Helen Rose, Blair, Elizabeth E., Packard, Chiara C., Velazquez, Maria, Macgregor, Lyn, and Grodsky, Eric
- Published
- 2022
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- View/download PDF
23. Common effects of bipolar disorder medications on expression quantitative trait loci genes
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Truong, Trang TT., Bortolasci, Chiara C., Kidnapillai, Srisaiyini, Spolding, Briana, Panizzutti, Bruna, Liu, Zoe SJ., Watmuff, Brad, Kim, Jee Hyun, Dean, Olivia M., Richardson, Mark, Berk, Michael, and Walder, Ken
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- 2022
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24. Intertwined associations between oxidative and nitrosative stress and endocannabinoid system pathways: Relevance for neuropsychiatric disorders
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Morris, Gerwyn, Walder, Ken, Berk, Michael, Carvalho, Andre F., Marx, Wolf, Bortolasci, Chiara C., Yung, Alison R., Puri, Basant K., and Maes, Michael
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- 2022
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25. Adjunctive minocycline for major depressive disorder: A sub-study exploring peripheral immune-inflammatory markers and associated treatment response
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Adam J. Walker, Mohammadreza Mohebbi, Michael Maes, Michael Berk, Ken Walder, Chiara C. Bortolasci, Zoe SJ. Liu, Chee H. Ng, Melanie M. Ashton, Lesley Berk, Ajeet B. Singh, Gin S. Malhi, and Olivia M. Dean
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Biomarkers ,Depression ,Inflammation ,Minocycline ,Neuroscience ,Psychiatry ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Background: Adjunctive minocycline shows promise in treating affective and psychotic disorders; however, the therapeutic mechanism remains unclear. Identifying relevant biomarkers may enhance the efficacy of novel adjunctive treatment candidates. We thus investigated the peripheral immune-inflammatory profile in a randomized controlled trial (RCT) of minocycline in major depressive disorder (MDD). Methods: This sub-study investigated serum samples from a RCT evaluating minocycline (200 mg/day, 12 weeks) in addition to treatment as usual for MDD (ACTRN12612000283875). Of the original sample (N = 71), serum assays were conducted in 47 participants (placebo n = 24; minocycline n = 23) targeting an array of 46 immune-inflammatory analytes including cytokines, chemokines, and acute-phase reactants. General estimating equations (GEE) were used to assess whether analyte concentration at baseline (effect modification) and change in analytes (change association) influenced change in Montgomery-Åsberg Depression Rating Scale (MADRS) score over time. The Benjamini–Hochberg approach was applied when adjusting for false discovery rates (FDR). Results: GEE models revealed several interaction effects. After adjusting for FDR several change association-models survived correction. However, no such models remained significant for effect modification. Three-way group × time × marker interactions were significant for complement C3 (B = −10.46, 95%CI [-16.832, −4.095], q = 0.019) and IL-1Ra (B = −9.008, 95%CI [-15.26, −2.751], q = 0.036). Two-way group × biomarker interactions were significant for ICAM-1/CD54 (B = −0.387, 95%CI [-0.513, −0.26], q
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- 2023
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26. Low spin spectroscopy of neutron-rich Cl43,44,45 via β− and βn decay
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Tripathi, Vandana, primary, Bhattacharya, Soumik, additional, Rubino, E., additional, Benetti, C., additional, Perello, J. F., additional, Tabor, S. L., additional, Liddick, S. N., additional, Bender, P. C., additional, Carpenter, M. P., additional, Carroll, J. J., additional, Chester, A., additional, Chiara, C. J., additional, Childers, K., additional, Clark, B. R., additional, Crider, B. P., additional, Harke, J. T., additional, Jain, R., additional, Longfellow, B., additional, Luitel, S., additional, Mogannam, M., additional, Ogunbeku, T. H., additional, Richard, A. L., additional, Saha, S., additional, Shimizu, N., additional, Shehu, O. A., additional, Utsuno, Y., additional, Unz, R., additional, Xiao, Y., additional, Yoshida, S., additional, and Zhu, Yiyi, additional
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- 2024
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27. Pharmacokinetics of Staccato® Alprazolam in Healthy Adult Participants: Phase 1, Randomized, Placebo-controlled Ethno-bridging Study (P9-1.007)
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Roebling, Robert, primary, Hayakawa, Yoshinobu, additional, Rospo, Chiara C., additional, Bartmann, Ana Paula, additional, King, Aliceson, additional, and Chanteux, Hugues, additional
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- 2024
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28. Pharmacokinetics and Tolerability of Single-dose Staccato® Alprazolam in Adolescents with Epilepsy and Population PK Analysis to Support Dose Selection in Adolescents (P9-1.002)
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Klein, Pavel, primary, Aungaroon, Gewalin, additional, Biton, Victor, additional, Liow, Kore Kai, additional, Phillips, Steven, additional, Wychowski, Thomas, additional, Sadek, Ahmed, additional, Elshoff, Jan-Peer, additional, Roebling, Robert, additional, King, Aliceson, additional, Ford, Andrea, additional, Rospo, Chiara C., additional, Schoemaker, Rik, additional, and Chanteux, Hugues, additional
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- 2024
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29. A candiru, Paracanthopoma sp. (Siluriformes: Trichomycteridae), associated with a thorny catfish, Doras phlyzakion (Siluriformes: Doradidae), in a tributary of the middle Rio Negro, Brazilian Amazon
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Chiara C. F. Lubich, André R. Martins, Carlos E. C. Freitas, Lawrence E. Hurd, and Flávia K. Siqueira-Souza
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Aquaculture. Fisheries. Angling ,SH1-691 - Abstract
Amazonian vampire catfish, known regionally as “candiru”, are recognized as hematophagous fishes, but information on their ecology remains limited. We provide the first report of Paracanthopoma sp. (Vandelliinae) found attached to the body surface of a thorny catfish, Doras phlyzakion Sabaj Pérez et Birindelli, 2008, bellow the lateral bony plates, rather than at the gills where they have usually been found. The specimens had not recently ingested blood or other identifiable fish remains (flesh, skin, or mucus), which could be an indication they have been using this host for protection or as a phoretic association, rather than for feeding. Thus, the interaction of vampire fish with the host catfish may be more complex than previously understood.
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- 2021
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30. Baseline serum amino acid levels predict treatment response to augmentation with N-acetylcysteine (NAC) in a bipolar disorder randomised trial
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Bortolasci, Chiara C., Turner, Alyna, Mohebbi, Mohammadreza, Liu, Zoe SJ., Ashton, Melanie, Gray, Laura, Marx, Wolfgang, Walker, Adam J., Kowalski, Greg M., Jacka, Felice, Berk, Michael, Dean, Olivia M., and Walder, Ken
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- 2021
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31. Unraveling Ascaris suum experimental infection in humans
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Silva, Thaís Eloi da, Barbosa, Fernando S., Magalhães, Luisa M.D., Gazzinelli-Guimarães, Pedro H., dos Santos, Anderson C., Nogueira, Denise S., Resende, Nathalia M., Amorim, Chiara C., Gazzinelli-Guimarães, Ana Clara, Viana, Agostinho G., Geiger, Stefan M., Bartholomeu, Daniella C., Fujiwara, Ricardo T., and Bueno, Lilian L.
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- 2021
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32. Single-particle and collective excitations in $^{62}$Ni
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Albers, M., Zhu, S., Ayangeakaa, A. D., Janssens, R. V. F., Gellanki, J., Ragnarsson, I., Alcorta, M., Baugher, T., Bertone, P. F., Carpenter, M. P., Chiara, C. J., Chowdhury, P., David, H. M., Deacon, A. N., DiGiovine, B., Gade, A., Hoffman, C. R., Kondev, F. G., Lauritsen, T., Lister, C. J., McCutchan, E. A., Nair, C., Rogers, A. M., and Seweryniak, D.
- Subjects
Nuclear Experiment - Abstract
{\bf Background:} Level sequences of rotational character have been observed in several nuclei in the $A=60$ mass region. The importance of the deformation-driving $\pi f_{7/2}$ and $\nu g_{9/2}$ orbitals on the onset of nuclear deformation is stressed.\\ {\bf Purpose:} A measurement was performed in order to identify collective rotational structures in the relatively neutron-rich $^{62}$Ni isotope. \\ {\bf Method:} The $^{26}$Mg($^{48}$Ca,2$\alpha$4$n\gamma$)$^{62}$Ni complex reaction at beam energies between 275 and 320~MeV was utilized. Reaction products were identified in mass ($A$) and charge ($Z$) with the Fragment Mass Analyzer (FMA) and $\gamma$ rays were detected with the Gammasphere array. \\ {\bf Results:} Two collective bands, built upon states of single-particle character, were identified and sizable deformation was assigned to both sequences based on the measured transitional quadrupole moments, herewith quantifying the deformation at high spin. \\ {\bf Conclusions:} Based on Cranked Nilsson-Strutinsky calculations and comparisons with deformed bands in the $A=60$ mass region, the two rotational bands are understood as being associated with configurations involving multiple $f_{7/2}$ protons and $g_{9/2}$ neutrons, driving the nucleus to sizable prolate deformation.
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- 2016
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33. In-beam spectroscopy of medium- and high-spin states in $^{133}$Ce
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Ayangeakaa, A. D., Garg, U., Petrache, C. M., Guo, S., Zhao, P. W., Matta, J. T., Nayak, B. K., Patel, D., Janssens, R. V. F., Carpenter, M. P., Chiara, C. J., Kondev, F. G., Lauritsen, T., Seweryniak, D., Zhu, S., Ghugre, S. S., and Palit, R.
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Nuclear Experiment - Abstract
Medium and high-spin states in $^{133}$Ce were investigated using the $^{116}$Cd($^{22}$Ne, $5n$) reaction and the Gammasphere array. The level scheme was extended up to an excitation energy of $\sim22.8$ MeV and spin 93/2 . Eleven bands of quadrupole transitions and two new dipole bands are identified. The connections to low-lying states of the previously known, high-spin triaxial bands were firmly established, thus fixing the excitation energy and, in many cases, the spin parity of the levels. Based on comparisons with cranked Nilsson-Strutinsky calculations and tilted axis cranking covariant density functional theory, it is shown that all observed bands are characterized by pronounced triaxiality. Competing multiquasiparticle configurations are found to contribute to a rich variety of collective phenomena in this nucleus., Comment: 20 pages, 11 figures
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- 2016
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34. Shape coexistence and the role of axial asymmetry in $^{72}$Ge
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Ayangeakaa, A. D., Janssens, R. V. F., Wu, C. Y., Allmond, J. M., Wood, J. L., Zhu, S., Albers, M., Almaras-Calderon, S., Bucher, B., Carpenter, M. P., Chiara, C. J., Cline, D., Crawford, H. L., David, H. M., Harker, J., Hayes, A. B., Hoffman, C. R., Kay, B. P., Kolos, K., Korichi, A., Lauritsen, T., Macchiavelli, A. O., Richard, A., Seweryniak, D., and Wiens, A.
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Nuclear Experiment ,Nuclear Theory - Abstract
The quadrupole collectivity of low-lying states and the anomalous behavior of the $0^+_2$ and $2^+_3$ levels in $^{72}$Ge are investigated via projectile multi-step Coulomb excitation with GRETINA and CHICO-2. A total of forty six $E2$ and $M1$ matrix elements connecting fourteen low-lying levels were determined using the least-squares search code, gosia. Evidence for triaxiality and shape coexistence, based on the model-independent shape invariants deduced from the Kumar-Cline sum rule, is presented. These are interpreted using a simple two-state mixing model as well as multistate mixing calculations carried out within the framework of the triaxial rotor model. The results represent a significant milestone towards the understanding of the unusual structure of this nucleus., Comment: 7 pages and 7 figures
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- 2016
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35. Direct Evidence of Octupole Deformation in Neutron-Rich $^{144}$Ba
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Bucher, B., Zhu, S., Wu, C. Y., Janssens, R. V. F., Cline, D., Hayes, A. B., Albers, M., Ayangeakaa, A. D., Butler, P. A., Campbell, C. M., Carpenter, M. P., Chiara, C. J., Clark, J. A., Crawford, H. L., Cromaz, M., David, H. M., Dickerson, C., Gregor, E. T., Harker, J., Hoffman, C. R., Kay, B. P., Kondev, F. G., Korichi, A., Lauritsen, T., Macchiavelli, A. O., Pardo, R. C., Richard, A., Riley, M. A., Savard, G., Scheck, M., Seweryniak, D., Smith, M. K., Vondrasek, R., and Wiens, A.
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Nuclear Experiment - Abstract
The neutron-rich nucleus $^{144}$Ba ($t_{1/2}$=11.5 s) is expected to exhibit some of the strongest octupole correlations among nuclei with mass numbers $A$ less than 200. Until now, indirect evidence for such strong correlations has been inferred from observations such as enhanced $E1$ transitions and interleaving positive- and negative-parity levels in the ground-state band. In this experiment, the octupole strength was measured directly by sub-barrier, multi-step Coulomb excitation of a post-accelerated 650-MeV $^{144}$Ba beam on a 1.0-mg/cm$^2$ $^{208}$Pb target. The measured value of the matrix element, $\langle 3_1^- \| \mathcal{M}(E3) \| 0_1^+ \rangle=0.65(^{+17}_{-23})$ $e$b$^{3/2}$, corresponds to a reduced $B(E3)$ transition probability of 48($^{+25}_{-34}$) W.u. This result represents an unambiguous determination of the octupole collectivity, is larger than any available theoretical prediction, and is consistent with octupole deformation., Comment: 5 pages, 2 figures, 1 table, Physical Review Letters 2016
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- 2016
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36. Independent measurement of the Hoyle state $\beta$ feeding from 12B using Gammasphere
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Munch, M., Alcorta, M., Fynbo, H. O. U., Albers, M., Almaraz-Calderon, S., Avila, M. L., Ayangeakaa, A. D., Back, B. B., Bertone, P. F., Carnelli, P. F. F., Carpenter, M. P., Chiara, C. J., Clark, J. A., DiGiovine, B., Greene, J. P., Harker, J. L., Hoffman, C. R., Hubbard, N. J., Jiang, C. L., Kirsebom, O. S., Lauritsen, T., Laursen, K. L., Marley, S. T., Nair, C., Nusair, O., Santiago-Gonzalez, D., Sethi, J., Seweryniak, D., Talwar, R., Ugalde, C., and Zhu, S.
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Nuclear Experiment - Abstract
Using an array of high-purity Compton-suppressed germanium detectors, we performed an independent measurement of the $\beta$-decay branching ratio from $^{12}\mathrm{B}$ to the second-excited (Hoyle) state in $^{12}\mathrm{C}$. Our result is $0.64(11)\%$, which is a factor $\sim 2$ smaller than the previously established literature value, but is in agreement with another recent measurement. This could indicate that the Hoyle state is more clustered than previously believed. The angular correlation of the Hoyle state $\gamma$ cascade has also been measured for the first time. It is consistent with theoretical predictions.
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- 2016
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37. $\gamma$-soft $^{146}$Ba and the role of non-axial shapes at N ~ 90
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Mitchell, A. J., Lister, C. J., McCutchan, E. A., Albers, M., Ayangeakaa, A. D., Bertone, P. F., Carpenter, M. P., Chiara, C. J., Chowdhury, P., Clark, J. A., Copp, P., David, H. M., Deo, A. Y., DiGiovine, B., D'Olympia, N., Dungan, R., Harding, R. D., Harker, J., Hota, S. S., Janssens, R. V. F., Kondev, F. G., Liu, S. H., Ramayya, A. V., Rissanen, J., Savard, G., Seweryniak, D., Shearman, R., Sonzogni, A. A., Tabor, S. L., Walters, W. B., Wang, E., and Zhu, S.
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Nuclear Experiment - Abstract
Low-spin states in the neutron-rich, N = 90 nuclide $^{146}$Ba were populated following $\beta$-decay of $^{146}$Cs, with the goal of clarifying the development of deformation in Ba isotopes through delineation of their non-yrast structures. Fission fragments of $^{146}$Cs were extracted from a 1.7-Ci $^{252}$Cf source and mass-selected using the CARIBU facility. Low-energy ions were deposited at the center of a box of thin $\beta$ detectors, surrounded by a high-efficiency HPGe array. The new $^{146}$Ba decay scheme now contains 31 excited levels extending up to ~2.5 MeV excitation energy, double what was previously known. These data are compared to predictions from the Interacting Boson Approximation (IBA) model. It appears that the abrupt shape change found at N = 90 in Sm and Gd is much more gradual in Ba and Ce, due to an enhanced role of the $\gamma$ degree of freedom., Comment: 10 pages, 8 figures, accepted to Physical Review C
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- 2015
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38. The role of high-density lipoprotein cholesterol, apolipoprotein A and paraoxonase-1 in the pathophysiology of neuroprogressive disorders
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Morris, Gerwyn, Puri, Basant K., Bortolasci, Chiara C., Carvalho, Andre, Berk, Michael, Walder, Ken, Moreira, Estefania G., and Maes, Michael
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- 2021
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39. Systemic inflammation and grey matter volume in schizophrenia and bipolar disorder: Moderation by childhood trauma severity
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Quidé, Yann, Bortolasci, Chiara C., Spolding, Briana, Kidnapillai, Srisaiyini, Watkeys, Oliver J., Cohen-Woods, Sarah, Carr, Vaughan J., Berk, Michael, Walder, Ken, and Green, Melissa J.
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- 2021
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40. Association between serum interleukin-6 and frailty in older men: cross-sectional data
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Tembo, Monica C., Holloway-Kew, Kara L., Bortolasci, Chiara C., Brennan-Olsen, Sharon L., Williams, Lana J., Kotowicz, Mark A., and Pasco, Julie A.
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- 2021
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41. Trace Amine-Associated Receptor 1 (TAAR1): A new drug target for psychiatry?
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Dodd, Seetal, F. Carvalho, André, Puri, Basant K., Maes, Michael, Bortolasci, Chiara C., Morris, Gerwyn, and Berk, Michael
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- 2021
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42. Risk of SARS-CoV-2 Reinfection in Children Within the 12 Months Following Mild COVID-19: Insights From a Survey Study
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Di Chiara, C, Boracchini, R, Cantarutti, A, Kakkar, F, Oletto, A, Padoan, A, Donà, D, Giaquinto, C, Di Chiara, Costanza, Boracchini, Riccardo, Cantarutti, Anna, Kakkar, Fatima, Oletto, Andrea, Padoan, Andrea, Donà, Daniele, Giaquinto, Carlo, Di Chiara, C, Boracchini, R, Cantarutti, A, Kakkar, F, Oletto, A, Padoan, A, Donà, D, Giaquinto, C, Di Chiara, Costanza, Boracchini, Riccardo, Cantarutti, Anna, Kakkar, Fatima, Oletto, Andrea, Padoan, Andrea, Donà, Daniele, and Giaquinto, Carlo
- Abstract
Understanding the correlation between immune response and protection from COVID-19 will play a pivotal role in predicting the effectiveness of vaccines in children. We studied SARS-CoV-2 reinfection risk in children 12 months post-mild COVID-19. Children under 5 years old exhibited lower reinfection risk than older infected or vaccinated siblings during 12 months postimmunization.
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- 2024
43. Stronger and durable SARS-CoV-2 immune response to mRNA vaccines in 5-11 years old children with prior COVID-19
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Di Chiara, C, Cantarutti, A, Raffaella Petrara, M, Bonfante, F, Benetti, E, Boracchini, R, Bosa, L, Carmona, F, Cosma, C, Cotugno, N, Le Prevost, M, Martini, G, Meneghel, A, Pagliari, M, Palma, P, Ruffoni, E, Zin, A, De Rossi, A, Giaquinto, C, Donà, D, Padoan, A, Di Chiara, Costanza, Cantarutti, Anna, Raffaella Petrara, Maria, Bonfante, Francesco, Benetti, Elisa, Boracchini, Riccardo, Bosa, Luca, Carmona, Francesco, Cosma, Chiara, Cotugno, Nicola, Le Prevost, Marthe, Martini, Giorgia, Meneghel, Alessandra, Pagliari, Matteo, Palma, Paolo, Ruffoni, Elena, Zin, Annachiara, De Rossi, Anita, Giaquinto, Carlo, Donà, Daniele, Padoan, Andrea, Di Chiara, C, Cantarutti, A, Raffaella Petrara, M, Bonfante, F, Benetti, E, Boracchini, R, Bosa, L, Carmona, F, Cosma, C, Cotugno, N, Le Prevost, M, Martini, G, Meneghel, A, Pagliari, M, Palma, P, Ruffoni, E, Zin, A, De Rossi, A, Giaquinto, C, Donà, D, Padoan, A, Di Chiara, Costanza, Cantarutti, Anna, Raffaella Petrara, Maria, Bonfante, Francesco, Benetti, Elisa, Boracchini, Riccardo, Bosa, Luca, Carmona, Francesco, Cosma, Chiara, Cotugno, Nicola, Le Prevost, Marthe, Martini, Giorgia, Meneghel, Alessandra, Pagliari, Matteo, Palma, Paolo, Ruffoni, Elena, Zin, Annachiara, De Rossi, Anita, Giaquinto, Carlo, Donà, Daniele, and Padoan, Andrea
- Abstract
Background and objectives: mRNA vaccines elicit a durable humoral response to SARS-CoV-2 in adults, whereas evidence in children is scarce. This study aimed to assess the early and long-term immune response to the mRNA vaccine in children with or without previous SARS-CoV-2 infection. Methods: In a multicentre prospective observational study, we profiled the immune response to the Pfizer BioNTech (BNT162b2) vaccine in 5-11-year-old children attending the University Pediatric Hospital of Padua and Bambino-Gesu Hospital in Rome (Italy) from December-2021 to February-2023. Blood samples were collected pre-, 1-, and 6-months after vaccination. Neutralizing antibodies (NAbs) and anti-spike-receptor-binding-domain (anti-S-RBD) IgG titers were analyzed through Plaque Reduction Neutralization Test (PRNT) and chemiluminescent immune-enzymatic assay (CLIA), respectively. Immune cell phenotypes were analyzed by flow cytometry. Results: Sixty children (26 [43 %] female, median age = 8 years [IQR = 7-10.7]) were enrolled in the study, including 46 children with a laboratory-confirmed previous COVID-19 (SARS-CoV-2-recovered) and 14 SARS CoV-2-naive participants defined as the absence of antigen-specific antibodies before vaccination. SARS-CoV-2recovered participants recorded higher anti-S-RBD IgG and Wild-type and Omicron BA.2 NAbs titers than SARSCoV-2-naive participants at both 1- and 6-months after vaccination. Antibody titers correlated with T (Tregs) and B (Bregs) regulatory cell frequencies in SARS-CoV-2-recovered children. Both SARS-CoV-2-recovered and SARSCoV-2-naive participants decreased antibody titers by approximately 100 to 250 % from 1 to 6 months. While children with immunocompromising underlying conditions developed immune responses comparable to those of healthy children, solid organ transplant recipients exhibited lower levels of NAbs and anti-S-RBD IgG titers, as well as reduced frequencies of Tregs and Bregs. Conclusions: mRNA vaccination triggered a higher pr
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- 2024
44. Determinants of increased nursing workload in the COVID-era: A retrospective analysis of prospectively collected data
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Lucchini, A, Villa, M, Del Sorbo, A, Pigato, I, D'Andrea, L, Greco, M, Chiara, C, Cesana, M, Rona, R, Giani, M, Lucchini, Alberto, Villa, Marta, Del Sorbo, Arianna, Pigato, Irene, D'Andrea, Luca, Greco, Matteo, Chiara, Colombo, Cesana, Matteo, Rona, Roberto, Giani, Marco, Lucchini, A, Villa, M, Del Sorbo, A, Pigato, I, D'Andrea, L, Greco, M, Chiara, C, Cesana, M, Rona, R, Giani, M, Lucchini, Alberto, Villa, Marta, Del Sorbo, Arianna, Pigato, Irene, D'Andrea, Luca, Greco, Matteo, Chiara, Colombo, Cesana, Matteo, Rona, Roberto, and Giani, Marco
- Abstract
Background: COVID-19 is associated with increased nursing workload, therefore a high nurse-to-patient ratio would be required. Aim: To analyse difference in nursing workload, as expressed with the Nursing Activities Score (NAS), between COVID-19 patients versus control patients without COVID-19 disease (NCOVID-19 group) in an Italian Extracorporeal Membrane Oxygenation (ECMO) centre. Study Design: Retrospective analysis of prospectively collected data, enrolling consecutive patients admitted to a general Intensive Care Unit, between 1st May 2019 and 28th February 2021. A multivariate analysis was then performed to assess if COVID-19 disease was an independent predictor of higher NAS and to assess which other factors and procedures are independently associated with increased workload. Results: We enrolled 574 patients, of which 135 (24%) were in the COVID-19 group and 439 (76%) in the NCOVID-19 group. The average NAS was higher in the COVID-19 group (79 ± 11 vs. 65 ± 15, T = −10.026; p < 0.001). Prone positioning, continuous renal replacement therapy (CRRT) and ECMO were used more frequently in the COVID-19 group. A higher fraction of patients in the COVID group showed colonization from multidrug resistant bacteria. COVID-19 group had a higher duration of mechanical ventilation and longer ICU stay. The COVID-19 diagnosis was independently associated with a higher NAS. Other independent predictors of higher NAS were the use of prone positioning and continuous renal replacement therapy (CRRT). Colonization from multidrug resistant bacteria and ECMO support were not independently associated with higher NAS. Conclusions: The higher nursing workload in COVID-19 patients is mainly due to specific procedures required to treat the most hypoxemic patients, such as prone positioning. Colonization with multidrug resistant bacteria and ECMO support were not independently associated with a higher NAS. Relevance to Clinical Practice: Higher workload in COVID-19 patients was due
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- 2024
45. The $^{136}$Xe + $^{208}$Pb reaction: A test of models of multi-nucleon transfer reactions
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Barrett, J. S., Yanez, R., Loveland, W., Zhu, S., Ayangeakaa, A. D., Carpenter, M. P., Greene, J. P., Janssens, R. V. F., Lauritsen, T., McCutchan, E. A., Sonzogni, A. A., Chiara, C. J., Harker, J. L., and Walters, W. B.
- Subjects
Nuclear Experiment - Abstract
The yields of over 200 projectile-like fragments (PLFs) and target-like fragments (TLFs) from the interaction of (E$_{c.m.}$=450 MeV) $^{136}$Xe with a thick target of $^{208}$Pb were measured using Gammasphere and off-line $\gamma$-ray spectroscopy, giving a comprehensive picture of the production cross sections in this reaction.The measured yields were compared to predictions of the GRAZING model and the predictions of Zagrebaev and Greiner using a quantitative metric, the theory evaluation factor, {\bf tef}. The GRAZING model predictions are adequate for describing the yields of nuclei near the target or projectile but grossly underestimate the yields of all other products. The predictions of Zagrebaev and Greiner correctly describe the magnitude and maxima of the observed TLF transfer cross sections for a wide range of transfers ($\Delta$Z = -8 to $\Delta$Z = +2). However for $\Delta$Z =+4, the observed position of the maximum in the distribution is four neutrons richer than the predicted maximum. The predicted yields of the neutron-rich N=126 nuclei exceed the measured values by two orders of magnitude. Correlations between TLF and PLF yields are discussed.
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- 2015
46. The role of the g9/2 orbital in the development of collectivity in the A = 60 region: The case of 61Co
- Author
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Ayangeakaa, A. D., Zhu, S., Janssens, R. V. F., Carpenter, M. P., Albers, M., Alcorta, M., Baugher, T., Bertone, P. F., Chiara, C. J., Chowdhury, P., David, H. M., Deacon, A. N., DiGiovine, B., Gade, A., Hoffman, C. R., Kondev, F. G., Lauritsen, T., Lister, C. J., McCutchan, E. A., Moerland, D. S., Nair, C., Rogers, A. M., and Seweryniak, D.
- Subjects
Nuclear Experiment ,Nuclear Theory - Abstract
An extensive study of the level structure of 61Co has been performed following the complex 26Mg(48Ca, 2a4npg)61Co reaction at beam energies of 275, 290 and 320 MeV using Gammasphere and the Fragment Mass Analyzer (FMA). The low-spin structure is discussed within the framework of shell-model calculations using the GXPF1A effective interaction. Two quasi-rotational bands consisting of stretched-E2 transitions have been established up to spins I = 41/2 and (43/2), and excitation energies of 17 and 20 MeV, respectively. These are interpreted as signature partners built on a neutron {\nu}(g9/2)2 configuration coupled to a proton {\pi}p3/2 state, based on Cranked Shell Model (CSM) calculations and comparisons with observations in neighboring nuclei. In addition, four I = 1 bands were populated to high spin, with the yrast dipole band interpreted as a possible candidate for the shears mechanism, a process seldom observed thus far in this mass region.
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- 2015
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47. Transverse Wobbling in $^{135}$Pr
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Matta, J. T., Garg, U., Li, W., Frauendorf, S., Ayangeakaa, A. D., Patel, D., Schlax, K. W., Palit, R., Saha, S., Sethi, J., Trivedi, T., Ghugre, S. S., Raut, R., Sinha, A. K., Janssens, R. V. F., Zhu, S., Carpenter, M. P., Lauritsen, T., Seweryniak, D., Chiara, C. J., Kondev, F. G., Hartley, D. J., Petrache, C. M., Mukhopadhyay, S., Lakshmi, D. Vijaya, Raju, M. Kumar, Rao, P. V. Madhusudhana, Tandel, S. K., Ray, S., and Dönau, F.
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Nuclear Experiment ,Nuclear Theory - Abstract
A pair of transverse wobbling bands has been observed in the nucleus $^{135}$Pr. The wobbling is characterized by $\Delta I$ =1, E2 transitions between the bands, and a decrease in the wobbling energy confirms its transverse nature. Additionally, a transition from transverse wobbling to a three-quasiparticle band comprised of strong magnetic dipole transitions is observed. These observations conform well to results from calculations with the Tilted Axis Cranking (TAC) model and the Quasiparticle Triaxial Rotor (QTR) Model., Comment: 6 pages; 5 figures; accepted for publication in the Physical Review Letters
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- 2015
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48. Co-Expression Networks Unveiled Long Non-Coding RNAs as Molecular Targets of Drugs Used to Treat Bipolar Disorder
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Trang TT. Truong, Chiara C. Bortolasci, Briana Spolding, Bruna Panizzutti, Zoe SJ. Liu, Srisaiyini Kidnapillai, Mark Richardson, Laura Gray, Craig M. Smith, Olivia M. Dean, Jee Hyun Kim, Michael Berk, and Ken Walder
- Subjects
bipolar disorders ,co-expression network ,WGCNA ,mood stabilizers ,lncRNAs ,treatments ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Long non-coding RNAs (lncRNAs) may play a role in psychiatric diseases including bipolar disorder (BD). We investigated mRNA-lncRNA co-expression patterns in neuronal-like cells treated with widely prescribed BD medications. The aim was to unveil insights into the complex mechanisms of BD medications and highlight potential targets for new drug development. Human neuronal-like (NT2-N) cells were treated with either lamotrigine, lithium, quetiapine, valproate or vehicle for 24 h. Genome-wide mRNA expression was quantified for weighted gene co-expression network analysis (WGCNA) to correlate the expression levels of mRNAs with lncRNAs. Functional enrichment analysis and hub lncRNA identification was conducted on key co-expressed modules associated with the drug response. We constructed lncRNA-mRNA co-expression networks and identified key modules underlying these treatments, as well as their enriched biological functions. Processes enriched in key modules included synaptic vesicle cycle, endoplasmic reticulum-related functions and neurodevelopment. Several lncRNAs such as GAS6-AS1 and MIR100HG were highlighted as driver genes of key modules. Our study demonstrates the key role of lncRNAs in the mechanism(s) of action of BD drugs. Several lncRNAs have been suggested as major regulators of medication effects and are worthy of further investigation as novel drug targets to treat BD.
- Published
- 2022
- Full Text
- View/download PDF
49. The pathophysiology of SARS-CoV-2: A suggested model and therapeutic approach
- Author
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Morris, Gerwyn, Bortolasci, Chiara C., Puri, Basant K., Olive, Lisa, Marx, Wolfgang, O'Neil, Adrienne, Athan, Eugene, Carvalho, Andre F., Maes, Michael, Walder, Ken, and Berk, Michael
- Published
- 2020
- Full Text
- View/download PDF
50. First Reported Histologically and Molecularly Confirmed Bilateral High-Grade Serous Ovarian Adenocarcinoma Metastasized to Placental Decidua of the Membranes
- Author
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El Emrani, Salma, primary, Nooij, Linda S., additional, Lap, Chiara C. M. M., additional, and van der Meeren, Lotte E., additional
- Published
- 2024
- Full Text
- View/download PDF
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