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Enzyme mimic studies are driven by a variety of factors, including understanding the function of the active site, replicating enzyme activity, and constructing bio‐inspired catalysts. In this study, we present a ferrocene‐conjugated copper complex (FcTrpCOO)Cu(bpy) that not only serves as a structural analog of Galactose oxidase (GOase) but also demonstrates impressive catalytic efficiency for alcohol oxidation via a photoredox process. Mechanistic investigations of the reaction were carried out using a range of spectroscopic techniques, including UV‐Vis, IR, CV, LC‐MS, XAS, and EPR. These findings offer valuable insights into the mechanism of alcohol oxidation in biological systems and provide a promising approach for developing efficient and eco‐friendly catalysts for chemical synthesis. [ABSTRACT FROM AUTHOR]

S-Nitrosothiols (SNOs) serve as endogenous carriers and donors of NO within living cells, releasing nitrosonium ions (NO+), NO, or other nitroso derivatives. In this study, we present a bioinspired {Co(NO)2}10 complex 1 that achieved S-nitrosation towards Cys residues. The incorporation of a ferrocenyl group in 1 allowed for fine-tuning of the nitrosation reaction, taking advantage of the redox ability of Cys residues. Complex 1 was synthesized and characterized, demonstrating its NO translation reactivity. Furthermore, complex 1 successfully converted Cys into S-nitrosocysteine (Cys-SNO), as confirmed by UV-Vis, IR, and XAS spectroscopy. This study presents a promising approach for S-nitrosation of Cys residues for further exploration in the modification of Cys-containing peptides. [ABSTRACT FROM AUTHOR]

Electrochemical synthesis in chemical biology is a milder, biocompatible, and environmentally friendly process for constructing novel types of bioconjugated systems. Herein, we report on the development of an indirect electrochemical strategy that allows a trifluoromethyl group to be incorporated into a tryptophan residue. This protocol allowed fluorinated peptides to be produced, thus allowing their characterization by 19F‐NMR. Interestingly, the trifluoromethylation of tryptophan did not appear under conditions of direct electrolysis; instead, as we introduced ferrocene as a mediator to allow indirect electrosynthesis, the desired product could be obtained in 67% isolated yield. Furthermore, various oligopeptides are successfully coupled to the Trp residue selectively. Mechanistic studies involving CV and DFT calculations indicated that the transformation proceeds through the homo‐cleavage of CF3SO2Na via ferrocene‐mediated indirect electrolysis. Subsequently, the addition of a CF3 radical allowed the labelled Trp to be incorporated into the corresponding products. This electrochemical protocol provides a new toolkit for the trifluoromethylation of peptides that contain tryptophan. [ABSTRACT FROM AUTHOR]

Electrospun polyimide (PI) separators were found to reduce the charge‐transfer resistance of Li plating/stripping and the overpotentials of Li nucleation/growth onto Cu foils in the 1.2 M LiPF6/(ethylene carbonate/dimethyl carbonate = 1/1) electrolyte without any additives in comparison with polyethylene (PE) separators. Lithium deposition through the PI separator led to the formation of a granular morphology of 15–30 µm in diameter compared to lithium dendrites using PE. A similar trend of lithium deposition was observed in LiFePO4//Cu cells. The PI separator was found to enhance the discharge capacity and cycle life of Li plating/stripping in the Li//Cu and LiFePO4//Cu cells containing 40 µl electrolytes, verifying that the PI separator provides dendrite inhibition capability for the lithium‐metal‐free cells. [ABSTRACT FROM AUTHOR]

Background: While the pharmacokinetic (PK) mechanisms for many drug interactions (DDIs) have been established, pharmacovigilance studies related to these PK DDIs are limited. Using a large surveillance database, a translational informatics approach can systematically screen adverse drug events (ADEs) for many DDIs with known PK mechanisms. Methods: We collected a set of substrates and inhibitors related to the cytochrome P450 (CYP) isoforms, as recommended by the United States Food and Drug Administration (FDA) and Drug Interactions Flockhart table™. The FDA's Adverse Events Reporting System (FAERS) was used to obtain ADE reports from 2004 to 2018. The substrate and inhibitor information were used to form PK DDI pairs for each of the CYP isoforms and Medical Dictionary for Regulatory Activities (MedDRA) preferred terms used for ADEs in FAERS. A shrinkage observed‐to‐expected ratio (Ω) analysis was performed to screen for potential PK DDI and ADE associations. Results: We identified 149 CYP substrates and 62 CYP inhibitors from the FDA and Flockhart tables. Using FAERS data, only those DDI‐ADE associations were considered that met the disproportionality threshold of Ω > 0 for a CYP substrate when paired with at least two inhibitors. In total, 590 ADEs were associated with 2085 PK DDI pairs and 38 individual substrates, with ADEs overlapping across different CYP substrates. More importantly, we were able to find clinical and experimental evidence for the paclitaxel‐clopidogrel interaction associated with peripheral neuropathy in our study. Conclusion: In this study, we utilized a translational informatics approach to discover potentially novel CYP‐related substrate‐inhibitor and ADE associations using FAERS. Future clinical, population‐based and experimental studies are needed to confirm our findings. [ABSTRACT FROM AUTHOR]