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128 results on '"Chia, Wei‐Tso"'

2. Inflammation‐Activated Endogenous Macrophage‐Mediated Prodrug Delivery System Overcoming Biological Barriers for Enhanced Oral Meningitis Therapy

Author

Nguyen, Van Khanh, primary, Nguyen, Nhien, additional, Li, Zhe‐Cheng, additional, Cheng, Chao‐Min, additional, Wang, Jui‐To, additional, Chiang, Yu‐Wei, additional, Song, Hsiang‐Lin, additional, Lo, Shih‐Kai, additional, Mac, Cam‐Hoa, additional, Chang, Yen, additional, Chia, Wei‐Tso, additional, and Sung, Hsing‐Wen, additional

Published
2024
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6. Allyl Isothiocyanate Suppresses the Proliferation in Oral Squamous Cell Carcinoma via Mediating the KDM8/CCNA1 Axis

Author

Hsieh, Cheng-Chih, primary, Yang, Cheng-Yu, additional, Peng, Bo, additional, Ho, Sien-Lin, additional, Tsao, Chang-Huei, additional, Lin, Chih-Kung, additional, Lin, Chun-Shu, additional, Lin, Gu-Jiun, additional, Lin, Heng-Yi, additional, Huang, Hung-Chi, additional, Chang, Szu-Chien, additional, Sytwu, Huey-Kang, additional, Chia, Wei-Tso, additional, and Chen, Yuan-Wu, additional

Published
2023
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15. Pollen-Mimetic Metal–Organic Frameworks with Tunable Spike-Like Nanostructures That Promote Cell Interactions to Improve Antigen-Specific Humoral Immunity

Author

Chen, Po-Ming, primary, Pan, Wen-Yu, additional, Luo, Po-Kai, additional, Phung, Hieu Nghia, additional, Liu, Yu-Miao, additional, Chiang, Min-Chun, additional, Chang, Wan-An, additional, Tien, Ting-Lun, additional, Huang, Chih-Yang, additional, Wu, Wen-Wei, additional, Chia, Wei-Tso, additional, and Sung, Hsing-Wen, additional

Published
2021
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17. Bioinspired Engineering of a Bacterium‐Like Metal–Organic Framework for Cancer Immunotherapy

Author

Chen, Po‐Ming, primary, Pan, Wen‐Yu, additional, Miao, Yang‐Bao, additional, Liu, Yu‐Miao, additional, Luo, Po‐Kai, additional, Phung, Hieu Nghia, additional, Wu, Wen‐Wei, additional, Ting, Yi‐Hsin, additional, Yeh, Ching‐Yen, additional, Chiang, Min‐Chun, additional, Chia, Wei‐Tso, additional, and Sung, Hsing‐Wen, additional

Published
2020
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22. IL-1β in Irrigation Fluid and MRNA Expression in Synovial Tissue of the Knee Joint as Therapeutic Markers of Inflammation in Collagen Antibody-Induced Arthritis

Author

Chia, Wei-Tso, Yeh, Li-Tzu, Chen, Yuan-Wu, Lee, Herng-Sheng, Chang, Deh-Ming, and Sytwu, Huey-Kang

Subjects
musculoskeletal diseases, lcsh:R5-920, lcsh:Medicine (General)
Abstract

Objective: We studied the relationship between the severity of inflammation and IL-1β production and relative expression level of IL-1β mRNA in irrigation fluid and synovial tissue obtained from the knee joint during the acute stage of a murine model of type II collagen antibody-induced arthritis (CAIA). This model is used to identify potential therapeutic markers for treating rheumatoid arthritis.Methods: Irrigation fluid and synovium tissue were harvested from the knee joint of BALB/c mice in acute stage of CAIA induction. The IL-1β protein level was measured by enzyme-linked immunosorbent assay, and the relative expression level of IL-1β mRNA was analyzed by reverse transcription-polymerase chain reaction. Two investigators analyzed expression levels and histopathological changes.Results: IL-1β concentration was higher in irrigation fluid from the knee joint than in the serum in the acute stage of CAIA. The relative expression level of IL-1β mRNA was elevated in synovial tissue. Histopathological changes in the knee joint and foot indicated similar severity.Conclusions: IL-1β concentration in irrigation fluid and relative expression level of IL-1β mRNA in the synovium have potential as therapeutic markers in studying and treating CAIA.

Published
2009

27. An In Situ Depot for Continuous Evolution of Gaseous H2 Mediated by a Magnesium Passivation/Activation Cycle for Treating Osteoarthritis.

Author

Wan, Wei‐Lin, Lin, Yu‐Jung, Shih, Po‐Chien, Bow, Yu‐Ru, Cui, Qinghua, Chang, Yen, Chia, Wei‐Tso, and Sung, Hsing‐Wen

Subjects
HYDROGEN evolution reactions, MAGNESIUM, PASSIVATION, OSTEOARTHRITIS treatment, ANTI-inflammatory agents, POLYLACTIC acid
Abstract

Abstract: Inflammation is involved in many human pathologies, including osteoarthritis (OA). Hydrogen (H2) is known to have anti‐inflammatory effects; however, the bioavailability of directly administered H2 gas is typically poor. Herein, a local delivery system that can provide a high therapeutic concentration of gaseous H2 at inflamed tissues is proposed. The delivery system comprises poly(lactic‐co‐glycolic acid) microparticles that contain magnesium powder (Mg@PLGA MPs). Mg@PLGA MPs that are intra‐muscularly injected close to the OA knee in a mouse model can act as an in situ depot that can evolve gaseous H2 continuously, mediated by the cycle of passivation/activation of Mg in body fluids, at a concentration that exceeds its therapeutic threshold. The analytical data that are obtained in the biochemical and histological studies indicate that the proposed Mg@PLGA MPs can effectively mitigate tissue inflammation and prevent cartilage from destruction, arresting the progression of OA changes. [ABSTRACT FROM AUTHOR]

Published
2018
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44. Carbon Monoxide Inhibits Receptor Activator of NF-kB (RANKL)-Induced Osteoclastogenesis.

Author

Tseng, Feng-Jen, Chia, Wei-Tso, Wang, Chih-Hung, Shyu, Jia-Fwu, Gou, Guo-Hau, Shui, Hao-ai, Sytwu, Huey-Kang, Pan, Ru-Yu, and Weng, Ching-Feng

Subjects
*NF-kappa B, *OSTEOCLASTOGENESIS, *ANTI-inflammatory agents, *APOPTOSIS, *PEROXISOME proliferator-activated receptors, *GENE expression
Abstract

Background: Low concentrations of carbon monoxide (CO) have anti-inflammatory effects and can reduce bone erosion in a murine collagen-induced arthritis model. The objective of this study was to assess the effects of CO on receptor activator of NF-KB ligand (RANKL), one of the key stimulators of osteoclastogenesis. Methods: The in vivo effects of CO on RANKL expression were assessed in a collagen antibody-induced arthritis model in mice. Cell proliferation and apoptosis were assessed in the RAW246.7 cell line stimulated with RANKL and exposed to either air or CO. The number of tartrate resistant acid phosphatase (TRAP)- positive RAW246.7 cells was also examined after treatment with RANKL and the peroxisome proliferator-activated receptor gamma (PPARy) agonist, Troglitazone. Results: CO reduced RANKL expression in the synovium of arthritic mice. Although CO slightly increased RAW246.7 cell proliferation, no differences in activated caspase 3 levels were detected. In addition, Troglitazone ameliorated the inhibitory effects of CO on RANKL-induced TRAP expression by RAW246.7 cells. Conclusions: CO suppresses osteoclast differentiation by inhibiting the RANKL-induced activation of PPAR-y. Given the role of the PPAR-y/cFos (AP-1) pathway in regulating the transcription factor, NFATc1, the master regulator of osteoclastogenesis, further studies are warranted to explore CO in treating inflammatory bone disorders. [ABSTRACT FROM AUTHOR]

Published
2015
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48. An In Situ Depot for Continuous Evolution of Gaseous H 2 Mediated by a Magnesium Passivation/Activation Cycle for Treating Osteoarthritis.

Author

Wan WL, Lin YJ, Shih PC, Bow YR, Cui Q, Chang Y, Chia WT, and Sung HW

Subjects
Animals, Humans, Magnesium chemistry, Mice, Organometallic Compounds chemical synthesis, Organometallic Compounds chemistry, Osteoarthritis metabolism, Osteoarthritis pathology, Particle Size, Polylactic Acid-Polyglycolic Acid Copolymer chemistry, RAW 264.7 Cells, Surface Properties, Hydrogen chemistry, Magnesium therapeutic use, Organometallic Compounds therapeutic use, Osteoarthritis drug therapy, Polylactic Acid-Polyglycolic Acid Copolymer therapeutic use
Abstract

Inflammation is involved in many human pathologies, including osteoarthritis (OA). Hydrogen (H 2 ) is known to have anti-inflammatory effects; however, the bioavailability of directly administered H 2 gas is typically poor. Herein, a local delivery system that can provide a high therapeutic concentration of gaseous H 2 at inflamed tissues is proposed. The delivery system comprises poly(lactic-co-glycolic acid) microparticles that contain magnesium powder (Mg@PLGA MPs). Mg@PLGA MPs that are intra-muscularly injected close to the OA knee in a mouse model can act as an in situ depot that can evolve gaseous H 2 continuously, mediated by the cycle of passivation/activation of Mg in body fluids, at a concentration that exceeds its therapeutic threshold. The analytical data that are obtained in the biochemical and histological studies indicate that the proposed Mg@PLGA MPs can effectively mitigate tissue inflammation and prevent cartilage from destruction, arresting the progression of OA changes., (© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Published
2018
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49. In Situ Nanoreactor for Photosynthesizing H 2 Gas To Mitigate Oxidative Stress in Tissue Inflammation.

Author

Wan WL, Lin YJ, Chen HL, Huang CC, Shih PC, Bow YR, Chia WT, and Sung HW

Subjects
Animals, Gold chemistry, Hydrogen chemistry, Inflammation chemically induced, Lipopolysaccharides metabolism, Mice, Molecular Conformation, RAW 264.7 Cells, Gold metabolism, Hydrogen metabolism, Inflammation metabolism, Metal Nanoparticles chemistry, Oxidative Stress, Photosynthesis
Abstract

Hydrogen gas can reduce cytotoxic reactive oxygen species (ROS) that are produced in inflamed tissues. Inspired by natural photosynthesis, this work proposes a multicomponent nanoreactor (NR) that comprises chlorophyll a, l-ascorbic acid, and gold nanoparticles that are encapsulated in a liposomal (Lip) system that can produce H 2 gas in situ upon photon absorption to mitigate inflammatory responses. Unlike a bulk system that contains free reacting molecules, this Lip NR system provides an optimal reaction environment, facilitating rapid activation of the photosynthesis of H 2 gas, locally providing a high therapeutic concentration thereof. The photodriven NR system reduces the degrees of overproduction of ROS and pro-inflammatory cytokines both in vitro in RAW264.7 cells and in vivo in mice with paw inflammation that is induced by lipopolysaccharide (LPS). Histological examinations of tissue sections confirm the ability of the NR system to reduce LPS-induced inflammation. Experimental results indicate that the Lip NR system that can photosynthesize H 2 gas has great potential for mitigating oxidative stress in tissue inflammation.

Published
2017
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50. A pH-Responsive Carrier System that Generates NO Bubbles to Trigger Drug Release and Reverse P-Glycoprotein-Mediated Multidrug Resistance.

Author

Chung MF, Liu HY, Lin KJ, Chia WT, and Sung HW

Subjects
ATP Binding Cassette Transporter, Subfamily B, Member 1 metabolism, Animals, Antineoplastic Agents chemistry, Camptothecin chemistry, Camptothecin pharmacology, Female, Humans, Hydrogen-Ion Concentration, Irinotecan, MCF-7 Cells, Mammary Neoplasms, Experimental drug therapy, Mammary Neoplasms, Experimental metabolism, Mammary Neoplasms, Experimental pathology, Mice, Mice, Nude, Nitric Oxide chemistry, ATP Binding Cassette Transporter, Subfamily B, Member 1 antagonists & inhibitors, Antineoplastic Agents pharmacology, Camptothecin analogs & derivatives, Drug Liberation, Drug Resistance, Multiple drug effects, Drug Resistance, Neoplasm drug effects, Nitric Oxide chemical synthesis
Abstract

Multidrug resistance (MDR) resulting from the overexpression of drug transporters such as P-glycoprotein (Pgp) increases the efflux of drugs and thereby limits the effectiveness of chemotherapy. To address this issue, this work develops an injectable hollow microsphere (HM) system that carries the anticancer agent irinotecan (CPT-11) and a NO-releasing donor (NONOate). Upon injection of this system into acidic tumor tissue, environmental protons infiltrate the shell of the HMs and react with their encapsulated NONOate to form NO bubbles that trigger localized drug release and serve as a Pgp-mediated MDR reversal agent. The site-specific drug release and the NO-reduced Pgp-mediated transport can cause the intracellular accumulation of the drug at a concentration that exceeds the cell-killing threshold, eventually inducing its antitumor activity. These results reveal that this pH-responsive HM carrier system provides a potentially effective method for treating cancers that develop MDR., (© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Published
2015
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