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3. Comparative Effectiveness of MRI, 4D-CT and Ultrasonography in Patients with Secondary Hyperparathyroidism

Author

Mi,Jiaoping, Fang,Yijie, Xian,Jianzhong, Wang,Guojie, Guo,Yuanqing, Hong,Haiyu, Chi,Mengshi, Li,Yong-Fang, He,Peng, Gao,Jiebing, Liao,Wei, Mi,Jiaoping, Fang,Yijie, Xian,Jianzhong, Wang,Guojie, Guo,Yuanqing, Hong,Haiyu, Chi,Mengshi, Li,Yong-Fang, He,Peng, Gao,Jiebing, and Liao,Wei

Abstract

Jiaoping Mi,1,2,* Yijie Fang,3,* Jianzhong Xian,4 Guojie Wang,3 Yuanqing Guo,5 Haiyu Hong,2 Mengshi Chi,2 Yong-Fang Li,2 Peng He,2 Jiebing Gao,3 Wei Liao2 1Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong, People’s Republic of China; 2Department of Otolaryngology Head and Neck Surgery, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong, People’s Republic of China; 3Department of Radiology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong, People’s Republic of China; 4Department of Ultrasound, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong, People’s Republic of China; 5Department of Spinal Surgery, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wei Liao, Department of Otolaryngology Head and Neck Surgery, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong, 519020, People’s Republic of China, Email liaowei23@mail.sysu.edu.cn Jiebing Gao, Department of Radiology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong, People’s Republic of China, Email Gaojb@mail.sysu.edu.cnObjective: Accurate preoperative localization of abnormal parathyroid glands is crucial for successful surgical management of secondary hyperparathyroidism (SHPT). This study was conducted to compare the effectiveness of preoperative MRI, 4D-CT, and ultrasonography (US) in localizing parathyroid lesions in patients with SHPT.Methods: We performed a retrospective review of prospectively collected data from a tertiary-care hospital and identified 52 patients who received preoperative MRI and/or 4D-CT and/or US and/or 99mTc-MIBI and subsequently underwent surgery for SHPT between May 2013 and March 2020. The sensitivity, specificity, positive predictive

Published
2023

4. RNAi-mediated knockdown of PFK1 decreases the invasive capability and metastasis of nasopharyngeal carcinoma cell line, CNE-2

Author

Chi Mengshi, Shuo Li, Shulin Chen, Wei Liao, Haiyu Hong, Zhigang Liu, He Peng, Fei Liu, Zhiwei Wang, Rongfei Su, Meng Liang, Nan Zen, and Huang Yili

Subjects
0301 basic medicine, Genetic enhancement, Phosphofructokinase-1, Apoptosis, Biology, medicine.disease_cause, Metastasis, 03 medical and health sciences, 0302 clinical medicine, RNA interference, Cell Line, Tumor, medicine, otorhinolaryngologic diseases, Humans, Neoplasm Metastasis, Molecular Biology, Cell Proliferation, Gene knockdown, Nasopharyngeal Carcinoma, Cell growth, Nasopharyngeal Neoplasms, Cell Biology, medicine.disease, Blot, Gene Expression Regulation, Neoplastic, stomatognathic diseases, 030104 developmental biology, Nasopharyngeal carcinoma, 030220 oncology & carcinogenesis, Cancer research, RNA Interference, Neoplasm Recurrence, Local, Carcinogenesis, Developmental Biology, Research Paper
Abstract

Nasopharyngeal carcinoma (NPC) is the most prevailing malignancy of the head and neck with unique geographic distribution. Southern China has one of the highest incidence rates of NPC in the world. Although radiotherapy and chemotherapy are the most important treatment modalities for NPC, recurrence, and metastasis severely interfere with the survival quality of patients. It is much-needed to find an effective method of NPC treatment with a good prognosis such as gene therapy. PFK1, a key regulatory enzyme of glycolysis, is frequently shown to be amplified and overexpressed in a variety of human cancers. However, the function of PFK1 and molecular mechanism in NPC is elusive. Here, we knockdown PFK1 expression by utilizing DNA vector-based RNA Interference. Western blotting and real-time PCR show that the expression of PFK1 is efficiently down-regulated in both protein and mRNA levels by stable transfection with PFK1 siRNA expression vector. In addition, stable knockdown of PFK1 expression inhibits cell growth, induces apoptosis, decreases the invasive capability and metastasis in the CNE2 human NPC cell line. This present study finds the importance of PFK1 which can be worked as a novel target in NPC treatment and holds great potential to be extended to other malignant cancers.

Published
2021

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