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BackgroundTechnology-mediated obesity treatments are commonly affected by poor long-term adherence. Supportive Accountability Theory suggests that the provision of social support and oversight toward goals may help to maintain adherence in technology-mediated treatments. However, no tool exists to measure the construct of supportive accountability. ObjectiveThis study aimed to develop and psychometrically validate a supportive accountability measure (SAM) by examining its performance in technology-mediated obesity treatment. MethodsSecondary data analyses were conducted in 2 obesity treatment studies to validate the SAM (20 items). Study 1 examined reliability, criterion validity, and construct validity using an exploratory factor analysis in individuals seeking obesity treatment. Study 2 examined the construct validity of SAM in technology-mediated interventions involving different self-monitoring tools and varying amounts of phone-based interventionist support. Participants received traditional self-monitoring tools (standard, in-home self-monitoring scale [SC group]), newer, technology-based self-monitoring tools (TECH group), or these newer technology tools plus additional phone-based support (TECH+PHONE group). Given that the TECH+PHONE group involves more interventionist support, we hypothesized that this group would have greater supportive accountability than the other 2 arms. ResultsIn Study 1 (n=353), the SAM showed strong reliability (Cronbach α=.92). A factor analysis revealed a 3-factor solution (representing Support for Healthy Eating Habits, Support for Exercise Habits, and Perceptions of Accountability) that explained 69% of the variance. Convergent validity was established using items from the motivation for weight loss scale, specifically the social regulation subscale (r=0.33; P

Abstract: Visceral sensory pathways mediate homeostatic reflexes, the dysfunction of which leads to many neurological disorders1. The Bezold–Jarisch reflex (BJR), first described2,3 in 1867, is a cardioinhibitory reflex that is speculated to be mediated by vagal sensory neurons (VSNs) that also triggers syncope. However, the molecular identity, anatomical organization, physiological characteristics and behavioural influence of cardiac VSNs remain mostly unknown. Here we leveraged single-cell RNA-sequencing data and HYBRiD tissue clearing4 to show that VSNs that express neuropeptide Y receptor Y2 (NPY2R) predominately connect the heart ventricular wall to the area postrema. Optogenetic activation of NPY2R VSNs elicits the classic triad of BJR responses—hypotension, bradycardia and suppressed respiration—and causes an animal to faint. Photostimulation during high-resolution echocardiography and laser Doppler flowmetry with behavioural observation revealed a range of phenotypes reflected in clinical syncope, including reduced cardiac output, cerebral hypoperfusion, pupil dilation and eye-roll. Large-scale Neuropixels brain recordings and machine-learning-based modelling showed that this manipulation causes the suppression of activity across a large distributed neuronal population that is not explained by changes in spontaneous behavioural movements. Additionally, bidirectional manipulation of the periventricular zone had a push–pull effect, with inhibition leading to longer syncope periods and activation inducing arousal. Finally, ablating NPY2R VSNs specifically abolished the BJR. Combined, these results demonstrate a genetically defined cardiac reflex that recapitulates characteristics of human syncope at physiological, behavioural and neural network levels.

Background: Fear is an under‐recognized issue in intervention adherence in head and neck cancer (HNC). We developed and validated a patient reported outcome for swallowing fear in HNC patients. Methods: Items were adapted from the Tampa Scale for Kinesiophobia to swallowing function. A beta version was completed by 51 HNC patients undergoing chemo +/− radiotherapy at baseline and post‐treatment. Psychometric and factor structure analyses were applied. Results: Swallowing Kinesiophobia Scale (SWKS) demonstrated strong face and content validity, internal consistency, and test‐retest reliability. Factor analysis revealed three‐factors: somatic factor, swallow avoidance, and fear of harm. Factors correlated positively with depression score, worry scale, and anxiety and pain scales. Score differences between patient subgroups (dysphagic vs nondysphagic) confirmed discriminative validity. Conclusion: The SWKS is a psychometrically valid tool to identify patients with fear of swallowing and swallowing‐related movement. It can help identify patients early in treatment who may need additional support. [ABSTRACT FROM AUTHOR]

Objective: Oropharyngeal squamous cell carcinoma (OPSCC) incidence is rapidly increasing, as are survival rates, in large part due to the human papillomavirus (HPV). Treatment intensity, however, has remained unchanged, making treatment-related toxicity (i.e., dysphagia) a critical problem for an increasing number of patients. The primary objective of this study was to determine whether pretreatment objective swallowing measures can predict percutaneous fluoroscopic guided gastrostomy tube (PFG) utilization during OPSCC treatment.Methods: Forty-one newly diagnosed OPSCC patients treated with radiation underwent evaluation of swallow function with modified barium swallow study (MBSS) prior to and at completion of radiation treatment using the Dynamic Imaging Grade of Swallowing Toxicity (DIGEST); a subset of patients were evaluated using the MD Anderson Dysphagia Inventory (MDADI).Results: Patients were male (100%), primarily Caucasian (85.4%) and p16 positive (85.4%) with mean age of 65.7 years. PFG were placed in 70.7% patients (n = 29) and used by 63.4% (n = 26). Pre- and post-treatment DIGEST scores were associated with T-classification (t = -2.9, p = .001, t = -2.7, p = .01) and indicated deteriorating swallow function during treatment (mean change = 0.46 [t = -2.7, p = .01]). DIGEST and MDADI scores were generally not associated with patient PFG utilization. DIGEST and MDADI scores were significantly correlated prior to, but not following completion of treatment.Conclusion: Pre-treatment DIGEST and patient reported swallowing outcomes (MDADI) can be useful in identifying patients with unsafe and/or grossly inefficient swallowing function. However, objectively measured swallow function was not associated with PFG utilization. Development of PFG placement algorithms (reactive vs. prophylactic) therefore require additional inputs/metrics.Level Of Evidence: 4 Laryngoscope, 130:2153-2159, 2020. [ABSTRACT FROM AUTHOR]

Background: Patients with head and neck cancer (HNC) experience significant physical and psychological morbidity during radiotherapy (RT) that contributes to treatment interruptions and a poor quality of life. Although spouses/partners can help by encouraging patient self-management (eg, self-care) during RT, they often experience high psychological distress rates, lack basic health care knowledge and skills, and report increased marital conflict regarding patient self-management. The current pilot study examined the feasibility and acceptability of a 6-session telephone-based intervention called Spouses coping with the Head And neck Radiation Experience (SHARE), which teaches self-management, communication, and coping skills to patients with HNC and their spouses. The treatment effects of SHARE compared with usual medical care (UMC) in controlling patient physical symptoms and improving patient/spouse psychological and marital functioning also were examined.Methods: Thirty patients who initiated RT and their spouses (60 participants; 40% of whom were racial/ethnic minorities) were randomized to SHARE or UMC, and preintervention and postintervention assessments were completed.Results: Solid recruitment (70%) and low attrition rates (7%) demonstrated feasibility. Strong program evaluations and homework completion rates (72%) supported acceptability. Significant treatment effects (medium in magnitude) were observed for SHARE compared with UMC with regard to HNC-specific physical symptom burden (Cohen's d, -0.89) and symptom interference (Cohen's d, -0.86). Medium to large effects favoring SHARE also were found for patient and spouse depressive symptoms (Cohen's d, -0.84) and cancer-specific distress (Cohen's d, -1.05).Conclusions: The findings of the current study support the feasibility, acceptability, and preliminary efficacy of SHARE. They also suggest that programs that empower HNC couples with the necessary skills to coordinate care and manage the challenges of RT together hold great promise for controlling a patient's physical symptoms and improving the psychological functioning of both partners. [ABSTRACT FROM AUTHOR]

Table of contents A1 Functional advantages of cell-type heterogeneity in neural circuits Tatyana O. Sharpee A2 Mesoscopic modeling of propagating waves in visual cortex Alain Destexhe A3 Dynamics and biomarkers of mental disorders Mitsuo Kawato F1 Precise recruitment of spiking output at theta frequencies requires dendritic h-channels in multi-compartment models of oriens-lacunosum/moleculare hippocampal interneurons Vladislav Sekulić, Frances K. Skinner F2 Kernel methods in reconstruction of current sources from extracellular potentials for single cells and the whole brains Daniel K. Wójcik, Chaitanya Chintaluri, Dorottya Cserpán, Zoltán Somogyvári F3 The synchronized periods depend on intracellular transcriptional repression mechanisms in circadian clocks. Jae Kyoung Kim, Zachary P. Kilpatrick, Matthew R. Bennett, Kresimir Josić O1 Assessing irregularity and coordination of spiking-bursting rhythms in central pattern generators Irene Elices, David Arroyo, Rafael Levi, Francisco B. Rodriguez, Pablo Varona O2 Regulation of top-down processing by cortically-projecting parvalbumin positive neurons in basal forebrain Eunjin Hwang, Bowon Kim, Hio-Been Han, Tae Kim, James T. McKenna, Ritchie E. Brown, Robert W. McCarley, Jee Hyun Choi O3 Modeling auditory stream segregation, build-up and bistability James Rankin, Pamela Osborn Popp, John Rinzel O4 Strong competition between tonotopic neural ensembles explains pitch-related dynamics of auditory cortex evoked fields Alejandro Tabas, André Rupp, Emili Balaguer-Ballester O5 A simple model of retinal response to multi-electrode stimulation Matias I. Maturana, David B. Grayden, Shaun L. Cloherty, Tatiana Kameneva, Michael R. Ibbotson, Hamish Meffin O6 Noise correlations in V4 area correlate with behavioral performance in visual discrimination task Veronika Koren, Timm Lochmann, Valentin Dragoi, Klaus Obermayer O7 Input-location dependent gain modulation in cerebellar nucleus neurons Maria Psarrou, Maria Schilstra, Neil Davey, Benjamin Torben-Nielsen, Volker Steuber O8 Analytic solution of cable energy function for cortical axons and dendrites Huiwen Ju, Jiao Yu, Michael L. Hines, Liang Chen, Yuguo Yu O9 C. elegans interactome: interactive visualization of Caenorhabditis elegans worm neuronal network Jimin Kim, Will Leahy, Eli Shlizerman O10 Is the model any good? Objective criteria for computational neuroscience model selection Justas Birgiolas, Richard C. Gerkin, Sharon M. Crook O11 Cooperation and competition of gamma oscillation mechanisms Atthaphon Viriyopase, Raoul-Martin Memmesheimer, Stan Gielen O12 A discrete structure of the brain waves Yuri Dabaghian, Justin DeVito, Luca Perotti O13 Direction-specific silencing of the Drosophila gaze stabilization system Anmo J. Kim, Lisa M. Fenk, Cheng Lyu, Gaby Maimon O14 What does the fruit fly think about values? A model of olfactory associative learning Chang Zhao, Yves Widmer, Simon Sprecher,Walter Senn O15 Effects of ionic diffusion on power spectra of local field potentials (LFP) Geir Halnes, Tuomo Mäki-Marttunen, Daniel Keller, Klas H. Pettersen,Ole A. Andreassen, Gaute T. Einevoll O16 Large-scale cortical models towards understanding relationship between brain structure abnormalities and cognitive deficits Yasunori Yamada O17 Spatial coarse-graining the brain: origin of minicolumns Moira L. Steyn-Ross, D. Alistair Steyn-Ross O18 Modeling large-scale cortical networks with laminar structure Jorge F. Mejias, John D. Murray, Henry Kennedy, Xiao-Jing Wang O19 Information filtering by partial synchronous spikes in a neural population Alexandra Kruscha, Jan Grewe, Jan Benda, Benjamin Lindner O20 Decoding context-dependent olfactory valence in Drosophila Laurent Badel, Kazumi Ohta, Yoshiko Tsuchimoto, Hokto Kazama P1 Neural network as a scale-free network: the role of a hub B. Kahng P2 Hemodynamic responses to emotions and decisions using near-infrared spectroscopy optical imaging Nicoladie D. Tam P3 Phase space analysis of hemodynamic responses to intentional movement directions using functional near-infrared spectroscopy (fNIRS) optical imaging technique Nicoladie D.Tam, Luca Pollonini, George Zouridakis P4 Modeling jamming avoidance of weakly electric fish Jaehyun Soh, DaeEun Kim P5 Synergy and redundancy of retinal ganglion cells in prediction Minsu Yoo, S. E. Palmer P6 A neural field model with a third dimension representing cortical depth Viviana Culmone, Ingo Bojak P7 Network analysis of a probabilistic connectivity model of the Xenopus tadpole spinal cord Andrea Ferrario, Robert Merrison-Hort, Roman Borisyuk P8 The recognition dynamics in the brain Chang Sub Kim P9 Multivariate spike train analysis using a positive definite kernel Taro Tezuka P10 Synchronization of burst periods may govern slow brain dynamics during general anesthesia Pangyu Joo P11 The ionic basis of heterogeneity affects stochastic synchrony Young-Ah Rho, Shawn D. Burton, G. Bard Ermentrout, Jaeseung Jeong, Nathaniel N. Urban P12 Circular statistics of noise in spike trains with a periodic component Petr Marsalek P14 Representations of directions in EEG-BCI using Gaussian readouts Hoon-Hee Kim, Seok-hyun Moon, Do-won Lee, Sung-beom Lee, Ji-yong Lee, Jaeseung Jeong P15 Action selection and reinforcement learning in basal ganglia during reaching movements Yaroslav I. Molkov, Khaldoun Hamade, Wondimu Teka, William H. Barnett, Taegyo Kim, Sergey Markin, Ilya A. Rybak P17 Axon guidance: modeling axonal growth in T-Junction assay Csaba Forro, Harald Dermutz, László Demkó, János Vörös P19 Transient cell assembly networks encode persistent spatial memories Yuri Dabaghian, Andrey Babichev P20 Theory of population coupling and applications to describe high order correlations in large populations of interacting neurons Haiping Huang P21 Design of biologically-realistic simulations for motor control Sergio Verduzco-Flores P22 Towards understanding the functional impact of the behavioural variability of neurons Filipa Dos Santos, Peter Andras P23 Different oscillatory dynamics underlying gamma entrainment deficits in schizophrenia Christoph Metzner, Achim Schweikard, Bartosz Zurowski P24 Memory recall and spike frequency adaptation James P. Roach, Leonard M. Sander, Michal R. Zochowski P25 Stability of neural networks and memory consolidation preferentially occur near criticality Quinton M. Skilling, Nicolette Ognjanovski, Sara J. Aton, Michal Zochowski P26 Stochastic Oscillation in Self-Organized Critical States of Small Systems: Sensitive Resting State in Neural Systems Sheng-Jun Wang, Guang Ouyang, Jing Guang, Mingsha Zhang, K. Y. Michael Wong, Changsong Zhou P27 Neurofield: a C++ library for fast simulation of 2D neural field models Peter A. Robinson, Paula Sanz-Leon, Peter M. Drysdale, Felix Fung, Romesh G. Abeysuriya, Chris J. Rennie, Xuelong Zhao P28 Action-based grounding: Beyond encoding/decoding in neural code Yoonsuck Choe, Huei-Fang Yang P29 Neural computation in a dynamical system with multiple time scales Yuanyuan Mi, Xiaohan Lin, Si Wu P30 Maximum entropy models for 3D layouts of orientation selectivity Joscha Liedtke, Manuel Schottdorf, Fred Wolf P31 A behavioral assay for probing computations underlying curiosity in rodents Yoriko Yamamura, Jeffery R. Wickens P32 Using statistical sampling to balance error function contributions to optimization of conductance-based models Timothy Rumbell, Julia Ramsey, Amy Reyes, Danel Draguljić, Patrick R. Hof, Jennifer Luebke, Christina M. Weaver P33 Exploration and implementation of a self-growing and self-organizing neuron network building algorithm Hu He, Xu Yang, Hailin Ma, Zhiheng Xu, Yuzhe Wang P34 Disrupted resting state brain network in obese subjects: a data-driven graph theory analysis Kwangyeol Baek, Laurel S. Morris, Prantik Kundu, Valerie Voon P35 Dynamics of cooperative excitatory and inhibitory plasticity Everton J. Agnes, Tim P. Vogels P36 Frequency-dependent oscillatory signal gating in feed-forward networks of integrate-and-fire neurons William F. Podlaski, Tim P. Vogels P37 Phenomenological neural model for adaptation of neurons in area IT Martin Giese, Pradeep Kuravi, Rufin Vogels P38 ICGenealogy: towards a common topology of neuronal ion channel function and genealogy in model and experiment Alexander Seeholzer, William Podlaski, Rajnish Ranjan, Tim Vogels P39 Temporal input discrimination from the interaction between dynamic synapses and neural subthreshold oscillations Joaquin J. Torres, Fabiano Baroni, Roberto Latorre, Pablo Varona P40 Different roles for transient and sustained activity during active visual processing Bart Gips, Eric Lowet, Mark J. Roberts, Peter de Weerd, Ole Jensen, Jan van der Eerden P41 Scale-free functional networks of 2D Ising model are highly robust against structural defects: neuroscience implications Abdorreza Goodarzinick, Mohammad D. Niry, Alireza Valizadeh P42 High frequency neuron can facilitate propagation of signal in neural networks Aref Pariz, Shervin S. Parsi, Alireza Valizadeh P43 Investigating the effect of Alzheimer’s disease related amyloidopathy on gamma oscillations in the CA1 region of the hippocampus Julia M. Warburton, Lucia Marucci, Francesco Tamagnini, Jon Brown, Krasimira Tsaneva-Atanasova P44 Long-tailed distributions of inhibitory and excitatory weights in a balanced network with eSTDP and iSTDP Florence I. Kleberg, Jochen Triesch P45 Simulation of EMG recording from hand muscle due to TMS of motor cortex Bahar Moezzi, Nicolangelo Iannella, Natalie Schaworonkow, Lukas Plogmacher, Mitchell R. Goldsworthy, Brenton Hordacre, Mark D. McDonnell, Michael C. Ridding, Jochen Triesch P46 Structure and dynamics of axon network formed in primary cell culture Martin Zapotocky, Daniel Smit, Coralie Fouquet, Alain Trembleau P47 Efficient signal processing and sampling in random networks that generate variability Sakyasingha Dasgupta, Isao Nishikawa, Kazuyuki Aihara, Taro Toyoizumi P48 Modeling the effect of riluzole on bursting in respiratory neural networks Daniel T. Robb, Nick Mellen, Natalia Toporikova P49 Mapping relaxation training using effective connectivity analysis Rongxiang Tang, Yi-Yuan Tang P50 Modeling neuron oscillation of implicit sequence learning Guangsheng Liang, Seth A. Kiser, James H. Howard, Jr., Yi-Yuan Tang P51 The role of cerebellar short-term synaptic plasticity in the pathology and medication of downbeat nystagmus Julia Goncharenko, Neil Davey, Maria Schilstra, Volker Steuber P52 Nonlinear response of noisy neurons Sergej O. Voronenko, Benjamin Lindner P53 Behavioral embedding suggests multiple chaotic dimensions underlie C. elegans locomotion Tosif Ahamed, Greg Stephens P54 Fast and scalable spike sorting for large and dense multi-electrodes recordings Pierre Yger, Baptiste Lefebvre, Giulia Lia Beatrice Spampinato, Elric Esposito, Marcel Stimberg et Olivier Marre P55 Sufficient sampling rates for fast hand motion tracking Hansol Choi, Min-Ho Song P56 Linear readout of object manifolds SueYeon Chung, Dan D. Lee, Haim Sompolinsky P57 Differentiating models of intrinsic bursting and rhythm generation of the respiratory pre-Bötzinger complex using phase response curves Ryan S. Phillips, Jeffrey Smith P58 The effect of inhibitory cell network interactions during theta rhythms on extracellular field potentials in CA1 hippocampus Alexandra Pierri Chatzikalymniou, Katie Ferguson, Frances K. Skinner P59 Expansion recoding through sparse sampling in the cerebellar input layer speeds learning N. Alex Cayco Gajic, Claudia Clopath, R. Angus Silver P60 A set of curated cortical models at multiple scales on Open Source Brain Padraig Gleeson, Boris Marin, Sadra Sadeh, Adrian Quintana, Matteo Cantarelli, Salvador Dura-Bernal, William W. Lytton, Andrew Davison, R. Angus Silver P61 A synaptic story of dynamical information encoding in neural adaptation Luozheng Li, Wenhao Zhang, Yuanyuan Mi, Dahui Wang, Si Wu P62 Physical modeling of rule-observant rodent behavior Youngjo Song, Sol Park, Ilhwan Choi, Jaeseung Jeong, Hee-sup Shin P64 Predictive coding in area V4 and prefrontal cortex explains dynamic discrimination of partially occluded shapes Hannah Choi, Anitha Pasupathy, Eric Shea-Brown P65 Stability of FORCE learning on spiking and rate-based networks Dongsung Huh, Terrence J. Sejnowski P66 Stabilising STDP in striatal neurons for reliable fast state recognition in noisy environments Simon M. Vogt, Arvind Kumar, Robert Schmidt P67 Electrodiffusion in one- and two-compartment neuron models for characterizing cellular effects of electrical stimulation Stephen Van Wert, Steven J. Schiff P68 STDP improves speech recognition capabilities in spiking recurrent circuits parameterized via differential evolution Markov Chain Monte Carlo Richard Veale, Matthias Scheutz P69 Bidirectional transformation between dominant cortical neural activities and phase difference distributions Sang Wan Lee P70 Maturation of sensory networks through homeostatic structural plasticity Júlia Gallinaro, Stefan Rotter P71 Corticothalamic dynamics: structure, number of solutions and stability of steady-state solutions in the space of synaptic couplings Paula Sanz-Leon, Peter A. Robinson P72 Optogenetic versus electrical stimulation of the parkinsonian basal ganglia. Computational study Leonid L. Rubchinsky, Chung Ching Cheung, Shivakeshavan Ratnadurai-Giridharan P73 Exact spike-timing distribution reveals higher-order interactions of neurons Safura Rashid Shomali, Majid Nili Ahmadabadi, Hideaki Shimazaki, S. Nader Rasuli P74 Neural mechanism of visual perceptual learning using a multi-layered neural network Xiaochen Zhao, Malte J. Rasch P75 Inferring collective spiking dynamics from mostly unobserved systems Jens Wilting, Viola Priesemann P76 How to infer distributions in the brain from subsampled observations Anna Levina, Viola Priesemann P77 Influences of embedding and estimation strategies on the inferred memory of single spiking neurons Lucas Rudelt, Joseph T. Lizier, Viola Priesemann P78 A nearest-neighbours based estimator for transfer entropy between spike trains Joseph T. Lizier, Richard E. Spinney, Mikail Rubinov, Michael Wibral, Viola Priesemann P79 Active learning of psychometric functions with multinomial logistic models Ji Hyun Bak, Jonathan Pillow P81 Inferring low-dimensional network dynamics with variational latent Gaussian process Yuan Zaho, Il Memming Park P82 Computational investigation of energy landscapes in the resting state subcortical brain network Jiyoung Kang, Hae-Jeong Park P83 Local repulsive interaction between retinal ganglion cells can generate a consistent spatial periodicity of orientation map Jaeson Jang, Se-Bum Paik P84 Phase duration of bistable perception reveals intrinsic time scale of perceptual decision under noisy condition Woochul Choi, Se-Bum Paik P85 Feedforward convergence between retina and primary visual cortex can determine the structure of orientation map Changju Lee, Jaeson Jang, Se-Bum Paik P86 Computational method classifying neural network activity patterns for imaging data Min Song, Hyeonsu Lee, Se-Bum Paik P87 Symmetry of spike-timing-dependent-plasticity kernels regulates volatility of memory Youngjin Park, Woochul Choi, Se-Bum Paik P88 Effects of time-periodic coupling strength on the first-spike latency dynamics of a scale-free network of stochastic Hodgkin-Huxley neurons Ergin Yilmaz, Veli Baysal, Mahmut Ozer P89 Spectral properties of spiking responses in V1 and V4 change within the trial and are highly relevant for behavioral performance Veronika Koren, Klaus Obermayer P90 Methods for building accurate models of individual neurons Daniel Saska, Thomas Nowotny P91 A full size mathematical model of the early olfactory system of honeybees Ho Ka Chan, Alan Diamond, Thomas Nowotny P92 Stimulation-induced tuning of ongoing oscillations in spiking neural networks Christoph S. Herrmann, Micah M. Murray, Silvio Ionta, Axel Hutt, Jérémie Lefebvre P93 Decision-specific sequences of neural activity in balanced random networks driven by structured sensory input Philipp Weidel, Renato Duarte, Abigail Morrison P94 Modulation of tuning induced by abrupt reduction of SST cell activity Jung H. Lee, Ramakrishnan Iyer, Stefan Mihalas P95 The functional role of VIP cell activation during locomotion Jung H. Lee, Ramakrishnan Iyer, Christof Koch, Stefan Mihalas P96 Stochastic inference with spiking neural networks Mihai A. Petrovici, Luziwei Leng, Oliver Breitwieser, David Stöckel, Ilja Bytschok, Roman Martel, Johannes Bill, Johannes Schemmel, Karlheinz Meier P97 Modeling orientation-selective electrical stimulation with retinal prostheses Timothy B. Esler, Anthony N. Burkitt, David B. Grayden, Robert R. Kerr, Bahman Tahayori, Hamish Meffin P98 Ion channel noise can explain firing correlation in auditory nerves Bahar Moezzi, Nicolangelo Iannella, Mark D. McDonnell P99 Limits of temporal encoding of thalamocortical inputs in a neocortical microcircuit Max Nolte, Michael W. Reimann, Eilif Muller, Henry Markram P100 On the representation of arm reaching movements: a computational model Antonio Parziale, Rosa Senatore, Angelo Marcelli P101 A computational model for investigating the role of cerebellum in acquisition and retention of motor behavior Rosa Senatore, Antonio Parziale, Angelo Marcelli P102 The emergence of semantic categories from a large-scale brain network of semantic knowledge K. Skiker, M. Maouene P103 Multiscale modeling of M1 multitarget pharmacotherapy for dystonia Samuel A. Neymotin, Salvador Dura-Bernal, Alexandra Seidenstein, Peter Lakatos, Terence D. Sanger, William W. Lytton P104 Effect of network size on computational capacity Salvador Dura-Bernal, Rosemary J. Menzies, Campbell McLauchlan, Sacha J. van Albada, David J. Kedziora, Samuel Neymotin, William W. Lytton, Cliff C. Kerr P105 NetPyNE: a Python package for NEURON to facilitate development and parallel simulation of biological neuronal networks Salvador Dura-Bernal, Benjamin A. Suter, Samuel A. Neymotin, Cliff C. Kerr, Adrian Quintana, Padraig Gleeson, Gordon M. G. Shepherd, William W. Lytton P107 Inter-areal and inter-regional inhomogeneity in co-axial anisotropy of Cortical Point Spread in human visual areas Juhyoung Ryu, Sang-Hun Lee P108 Two bayesian quanta of uncertainty explain the temporal dynamics of cortical activity in the non-sensory areas during bistable perception Joonwon Lee, Sang-Hun Lee P109 Optimal and suboptimal integration of sensory and value information in perceptual decision making Hyang Jung Lee, Sang-Hun Lee P110 A Bayesian algorithm for phoneme Perception and its neural implementation Daeseob Lim, Sang-Hun Lee P111 Complexity of EEG signals is reduced during unconsciousness induced by ketamine and propofol Jisung Wang, Heonsoo Lee P112 Self-organized criticality of neural avalanche in a neural model on complex networks Nam Jung, Le Anh Quang, Seung Eun Maeng, Tae Ho Lee, Jae Woo Lee P113 Dynamic alterations in connection topology of the hippocampal network during ictal-like epileptiform activity in an in vitro rat model Chang-hyun Park, Sora Ahn, Jangsup Moon, Yun Seo Choi, Juhee Kim, Sang Beom Jun, Seungjun Lee, Hyang Woon Lee P114 Computational model to replicate seizure suppression effect by electrical stimulation Sora Ahn, Sumin Jo, Eunji Jun, Suin Yu, Hyang Woon Lee, Sang Beom Jun, Seungjun Lee P115 Identifying excitatory and inhibitory synapses in neuronal networks from spike trains using sorted local transfer entropy Felix Goetze, Pik-Yin Lai P116 Neural network model for obstacle avoidance based on neuromorphic computational model of boundary vector cell and head direction cell Seonghyun Kim, Jeehyun Kwag P117 Dynamic gating of spike pattern propagation by Hebbian and anti-Hebbian spike timing-dependent plasticity in excitatory feedforward network model Hyun Jae Jang, Jeehyun Kwag P118 Inferring characteristics of input correlations of cells exhibiting up-down state transitions in the rat striatum Marko Filipović, Ramon Reig, Ad Aertsen, Gilad Silberberg, Arvind Kumar P119 Graph properties of the functional connected brain under the influence of Alzheimer’s disease Claudia Bachmann, Simone Buttler, Heidi Jacobs, Kim Dillen, Gereon R. Fink, Juraj Kukolja, Abigail Morrison P120 Learning sparse representations in the olfactory bulb Daniel Kepple, Hamza Giaffar, Dima Rinberg, Steven Shea, Alex Koulakov P121 Functional classification of homologous basal-ganglia networks Jyotika Bahuguna,Tom Tetzlaff, Abigail Morrison, Arvind Kumar, Jeanette Hellgren Kotaleski P122 Short term memory based on multistability Tim Kunze, Andre Peterson, Thomas Knösche P123 A physiologically plausible, computationally efficient model and simulation software for mammalian motor units Minjung Kim, Hojeong Kim P125 Decoding laser-induced somatosensory information from EEG Ji Sung Park, Ji Won Yeon, Sung-Phil Kim P126 Phase synchronization of alpha activity for EEG-based personal authentication Jae-Hwan Kang, Chungho Lee, Sung-Phil Kim P129 Investigating phase-lags in sEEG data using spatially distributed time delays in a large-scale brain network model Andreas Spiegler, Spase Petkoski, Matias J. Palva, Viktor K. Jirsa P130 Epileptic seizures in the unfolding of a codimension-3 singularity Maria L. Saggio, Silvan F. Siep, Andreas Spiegler, William C. Stacey, Christophe Bernard, Viktor K. Jirsa P131 Incremental dimensional exploratory reasoning under multi-dimensional environment Oh-hyeon Choung, Yong Jeong P132 A low-cost model of eye movements and memory in personal visual cognition Yong-il Lee, Jaeseung Jeong P133 Complex network analysis of structural connectome of autism spectrum disorder patients Su Hyun Kim, Mir Jeong, Jaeseung Jeong P134 Cognitive motives and the neural correlates underlying human social information transmission, gossip Jeungmin Lee, Jaehyung Kwon, Jerald D. Kralik, Jaeseung Jeong P135 EEG hyperscanning detects neural oscillation for the social interaction during the economic decision-making Jaehwan Jahng, Dong-Uk Hwang, Jaeseung Jeong P136 Detecting purchase decision based on hyperfrontality of the EEG Jae-Hyung Kwon, Sang-Min Park, Jaeseung Jeong P137 Vulnerability-based critical neurons, synapses, and pathways in the Caenorhabditis elegans connectome Seongkyun Kim, Hyoungkyu Kim, Jerald D. Kralik, Jaeseung Jeong P138 Motif analysis reveals functionally asymmetrical neurons in C. elegans Pyeong Soo Kim, Seongkyun Kim, Hyoungkyu Kim, Jaeseung Jeong P139 Computational approach to preference-based serial decision dynamics: do temporal discounting and working memory affect it? Sangsup Yoon, Jaehyung Kwon, Sewoong Lim, Jaeseung Jeong P141 Social stress induced neural network reconfiguration affects decision making and learning in zebrafish Choongseok Park, Thomas Miller, Katie Clements, Sungwoo Ahn, Eoon Hye Ji, Fadi A. Issa P142 Descriptive, generative, and hybrid approaches for neural connectivity inference from neural activity data JeongHun Baek, Shigeyuki Oba, Junichiro Yoshimoto, Kenji Doya, Shin Ishii P145 Divergent-convergent synaptic connectivities accelerate coding in multilayered sensory systems Thiago S. Mosqueiro, Martin F. Strube-Bloss, Brian Smith, Ramon Huerta P146 Swinging networks Michal Hadrava, Jaroslav Hlinka P147 Inferring dynamically relevant motifs from oscillatory stimuli: challenges, pitfalls, and solutions Hannah Bos, Moritz Helias P148 Spatiotemporal mapping of brain network dynamics during cognitive tasks using magnetoencephalography and deep learning Charles M. Welzig, Zachary J. Harper P149 Multiscale complexity analysis for the segmentation of MRI images Won Sup Kim, In-Seob Shin, Hyeon-Man Baek, Seung Kee Han P150 A neuro-computational model of emotional attention René Richter, Julien Vitay, Frederick Beuth, Fred H. Hamker P151 Multi-site delayed feedback stimulation in parkinsonian networks Kelly Toppin, Yixin Guo P152 Bistability in Hodgkin–Huxley-type equations Tatiana Kameneva, Hamish Meffin, Anthony N. Burkitt, David B. Grayden P153 Phase changes in postsynaptic spiking due to synaptic connectivity and short term plasticity: mathematical analysis of frequency dependency Mark D. McDonnell, Bruce P. Graham P154 Quantifying resilience patterns in brain networks: the importance of directionality Penelope J. Kale, Leonardo L. Gollo P155 Dynamics of rate-model networks with separate excitatory and inhibitory populations Merav Stern, L. F. Abbott P156 A model for multi-stable dynamics in action recognition modulated by integration of silhouette and shading cues Leonid A. Fedorov, Martin A. Giese P157 Spiking model for the interaction between action recognition and action execution Mohammad Hovaidi Ardestani, Martin Giese P158 Surprise-modulated belief update: how to learn within changing environments? Mohammad Javad Faraji, Kerstin Preuschoff, Wulfram Gerstner P159 A fast, stochastic and adaptive model of auditory nerve responses to cochlear implant stimulation Margriet J. van Gendt, Jeroen J. Briaire, Randy K. Kalkman, Johan H. M. Frijns P160 Quantitative comparison of graph theoretical measures of simulated and empirical functional brain networks Won Hee Lee, Sophia Frangou P161 Determining discriminative properties of fMRI signals in schizophrenia using highly comparative time-series analysis Ben D. Fulcher, Patricia H. P. Tran, Alex Fornito P162 Emergence of narrowband LFP oscillations from completely asynchronous activity during seizures and high-frequency oscillations Stephen V. Gliske, William C. Stacey, Eugene Lim, Katherine A. Holman, Christian G. 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Background: Head and neck cancer (HNC) patients undergoing chemo/radiation commonly experience severe and persistent distress associated with treatment related fear and physical side effects such as xerostomia, dysphagia, and dryness of mouth. Cortisol, a stress sensitive hormone, can be easily measured in saliva to reflect biobehavioral responses to such stressors. Unfortunately, it has not been used in this population due to concerns associated with chemoradiation (C/RT) related xerostomia., Methods: In a proof-of-concept study, we explored the feasibility of collecting salivary cortisol as a marker of fear and distress in HNC patients. Ten HNC subjects undergoing C/RT provided saliva samples for 3 consecutive days across three timepoints (pre-treatment, 3-weeks and 1-month post-treatment) and completed concurrent depression, anxiety and swallowing related fear measures., Results: Salivary cortisol collection adherence was between 80-60%. It was not impacted by xerostomia. Diurnal cortisol pattern demonstrated dysregulation at pretreatment in 62%, and flattened aberrant slopes continued at 3-weeks and beyond in 50% of subjects., Conclusions: Our study supports the feasibility and utility of salivary cortisol measurement in HNC patients across the treatment trajectory. Diurnal cortisol measures may be a valuable tool to detect and monitor treatment distress during C/RT in this population., Competing Interests: COI: None to disclose