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2. Multicenter Evaluation of the Cepheid Xpert Hepatitis C Virus Viral Load Assay

Author

McHugh, MP, Wu, AHB, Chevaliez, S, Pawlotsky, JM, Hallin, M, and Templeton, KE

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Research, Hepatitis - C, HIV/AIDS, Chronic Liver Disease and Cirrhosis, Infectious Diseases, Digestive Diseases, Liver Disease, Emerging Infectious Diseases, Hepatitis, Infection, Good Health and Well Being, Genotype, Hepacivirus, Hepatitis C, Humans, RNA, Viral, Viral Load, HCV RNA, hepatitis C virus, viral load, Biological Sciences, Agricultural and Veterinary Sciences, Medical and Health Sciences, Microbiology, Clinical sciences, Medical microbiology
Abstract

Viral load monitoring for hepatitis C virus (HCV) is necessary to diagnose infection and monitor response to therapy, but the tests involved are currently confined to specialist institutions. There is a need for a fast, accurate assay with limited operator input to enhance the access to viral load monitoring. We evaluated the quantification of HCV RNA in serum and plasma by the Cepheid Xpert HCV Viral Load assay in comparison to the Abbott RealTime HCV assay. Serum and plasma samples were gathered from HCV-infected individuals at four international sites. These were tested with the Xpert HCV Viral Load assay, and results were compared to quantification by the Abbott RealTime HCV assay. An external quality assessment panel of eight samples was also tested. In total, 614 samples were analyzed in the study, and the qualitative results agreed on the two platforms for 588 (95.8%) samples. Further analysis of 396 samples quantified by both tests showed strong correlation (correlation coefficient r = 0.99) across the quantifiable range, with Bland-Altman plot data showing a mean difference (±1.96 standard deviation) of 0.03 ± 0.44 log10 IU/ml. In the external quality assessment panel, the Xpert HCV Viral Load assay results (quantified in log10 IU per milliliter) were within 1 standard deviation of the target value for all but one sample, which was also similarly misquantified by the Abbott RealTime HCV assay. The Xpert HCV Viral Load assay performs well compared to a market-leading HCV viral load test and should be considered for instances where rapid near-to-patient testing is required.

Published
2017

5. Efficacy, safety and patient‐reported outcomes of ledipasvir/sofosbuvir in NS3/4A protease inhibitor‐experienced individuals with hepatitis C virus genotype 1 and HIV coinfection with and without cirrhosis (ANRS HC31 SOFTRIH study)

Author

Rosenthal, E, Fougerou‐Leurent, C, Renault, A, Carrieri, MP, Marcellin, F, Garraffo, R, Teicher, E, Aumaitre, H, Lacombe, K, Bailly, F, Billaud, E, Chevaliez, S, Dominguez, S, Valantin, MA, Reynes, J, Naqvi, A, Cotte, L, Metivier, S, Leroy, V, Dupon, M, Allegre, T, De Truchis, P, Jeantils, V, Chas, J, Salmon‐Ceron, D, Morlat, P, Neau, D, Perré, P, Piroth, L, Pol, S, Bourlière, M, Pageaux, GP, Alric, L, Zucman, D, Girard, PM, Poizot‐Martin, I, Yazdanpanah, Y, Raffi, F, Pabic, E Le, Tual, C, Pailhé, A, Amri, I, Bellissant, E, Molina, JM, Gérard, Laurence, Duvivier, Claudine, Lafeuillade, Alain, Batisse, Dominique, Mortier, Emmanuel, Simon, Anne, Makhloufi, Djamila, Michelet, Christian, Cheret, Antoine, May, Thierry, Moreau, Jacques, de Ledinghen, Victor, Rosa, Isabelle, Ahmim, Mustapha, Raimon, Julie, Thierry, Régine, and Martin, Amélie

Published
2018
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8. Diagnostic Accuracy of Assays Using Point-of-Care Testing or Dried Blood Spot Samples for the Determination of Hepatitis C Virus RNA: A Systematic Review( )

Author

Catlett, B, Hajarizadeh, B, Cunningham, E, Wolfson-Stofko, B, Wheeler, A, Khandaker-Hussain, B, Feld, JJ, Martro, E, Chevaliez, S, Pawlotsky, JM, Bharat, C, Cunningham, PH, Dore, GJ, Applegate, T, and Grebely, J

Subjects
systematic review, HCV RNA, point-of-care, HCV, dried blood spot, diagnostic testing
Abstract

HCV active infection can be accurately detected by assays that utilize point-of-care testing or dried blood spot samples for the determination of HCV RNA. Background Finger-stick point-of-care and dried blood spot (DBS) hepatitis C virus (HCV) RNA testing increases testing uptake and linkage to care. This systematic review evaluated the diagnostic accuracy of point-of-care testing and DBS to detect HCV RNA. Methods Bibliographic databases and conference presentations were searched for eligible studies. Meta-analysis was used to pool estimates. Results Of 359 articles identified, 43 studies were eligible and included. When comparing the Xpert HCV Viral Load Fingerstick assay to venous blood samples (7 studies with 987 samples), the sensitivity and specificity for HCV RNA detection was 99% (95% confidence interval [CI], 97%-99%) and 99% (95% CI, 94%-100%) and for HCV RNA quantification was 100% (95% CI, 93%-100%) and 100% (95% CI, 94%-100%). The proportion of invalid results following Xpert HCV Viral Load Fingerstick testing was 6% (95% CI, 3%-11%). When comparing DBS to venous blood samples (28 studies with 3988 samples) the sensitivity and specificity for HCV RNA detection was 97% (95% CI, 95%-98%) and 100% (95% CI, 98%-100%) and for HCV RNA quantification was 98% (95% CI, 96%-99%) and 100% (95% CI, 95%-100%). Conclusions Excellent diagnostic accuracy was observed across assays for detection of HCV RNA from finger-stick and DBS samples. The proportion of invalid results following Xpert HCV Viral Load Fingerstick testing highlights the importance of operator training and quality assurance programs.

Published
2022

15. High prevalence and poor linkage to care of transfusion transmitted infections among blood donors in Dar-es-Salaam, Tanzania

Author

Mohamed, Z, Kim, JU, Magesa, A, Kasubi, M, Feldman, SF, Chevaliez, S, Mwakale, P, Taylor-Robinson, SD, Thursz, MR, Shimakawa, Y, Rwegasha, J, Lemoine, M, and Wellcome Trust

Subjects
sub-Saharan Africa, AFRICA, Science & Technology, Gastroenterology & Hepatology, GAMBIA, 1103 Clinical Sciences, transfusion-transmitted infections (TTIs), Infectious Diseases, 1108 Medical Microbiology, Virology, SAFETY, TESTS, blood donation, B-VIRUS INFECTION, Life Sciences & Biomedicine, linkage to care
Abstract

Blood transfusion is one of the most commonly relied upon therapies in sub‐Saharan Africa. Existing safeguards recommended include systematic screening for transfusion‐transmitted infections and restricted voluntary nonremunerated blood donor selection. We report the transfusion‐transmitted infection screening and notification practice at a large urban blood transfusion centre in Dar‐es‐Salaam, Tanzania. Between October 2016 and March 2017 anonymized records of all donors registered at the blood transfusion unit were accessed to retrospectively note demographic information, donor status, first‐time status, transfusion‐transmitted infection result and notification. 6402 consecutive donors were screened for transfusion‐transmitted infections; the majority were family/replacement blood donors (88.0%) and male (83.8%). Overall transfusion‐transmitted infections prevalence was 8.4% (95% CI 7.8‐9.1), with hepatitis B being the most prevalent infection (4.1% (95% CI 3.6‐4.6)). Transfusion‐transmitted infections were more common in family/replacement blood donors (9.0% (95% CI 8.3‐9.8)) as compared to voluntary nonremunerated blood donor (4.1% (95% CI 2.8‐5.7)). A minority of infected‐donors were notified of a positive result (8.5% (95% CI 6.3‐11.2)). Although transfusion‐transmitted infections are more prevalent among family/replacement blood donors, overall risk of transfusion‐transmitted infections across all groups is considerable. In addition, existing efforts to notify donors of a positive transfusion‐transmitted infection are poor. Future policies must focus on improving linkage to care for newly diagnosed patients with transfusion‐transmitted infections.

Published
2019

18. Hepatitis C subtype distribution in chronically infected patients with mild liver fibrosis in France: the GEMHEP study

Author

Semenova, T., primary, Nemoz, B., additional, Thibault, V., additional, Lagathu, G., additional, Duverlie, G., additional, Brochot, E., additional, Trimoulet, P., additional, Payan, C., additional, Vallet, S., additional, Henquell, C., additional, Chevaliez, S., additional, Bouvier-Alias, M., additional, Maylin, S., additional, Roque-Afonso, A-M., additional, Izquierdo, L., additional, Lunel-Fabiani, F., additional, Marcellin, P., additional, Morand, P., additional, Leroy, V., additional, and Larrat, S., additional

Published
2019
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19. ACKNOWLEDGEMENT OF REVIEWERS

Author

Adams, NG, Adekambi, T, Afeltra, J, Aguado, J, Aires de Sousa, M, Akiyoshi, K, Al Hasan, M, Ala-Kokko, T, Albert, M, Alfandari, S, Allen, D, Allerberger, F, Almyroudis, N, Alp, E, Amin, R, Anderson-Berry, A, Andes, DR, Andremont, A, Andreu, A, Angelakis, M, Antachopoulos, C, Antoniadou, A, Arabatzis, M, Arlet, G, Arnez, M, Arnold, C, Asensio, A, Asseray, N, Ausiello, C, Avni, T, Ayling, R, Baddour, L, Baguelin, M, Bányai, K, Barbour, A, Basco, LK, Bauer, D, Bayston, R, Beall, B, Becker, K, Behr, M, Bejon, P, Belliot, G, Benito-Fernandez, J, Benjamin, D, Benschop, K, Berencsi, G, Bergeron, MG, Bernard, K, Berner, R, Beyersmann, J, Bille, J, Bizzini, A, Bjarnsholt, T, Blanc, D, Blanco, J, Blot, S, Bohnert, J, Boillat, N, Bonomo, R, Bonten, M, Bordon, JM, Borel, N, Boschiroli, ML, Bosilkovski, M, Bosso, JA, Botelho-Nevers, E, Bou, G, Bretagne, S, Brouqui, P, Brun-Buisson, C, Brunetto, M, Bucher, H, Buchheidt, D, Buckling, A, Bulpa, P, Cambau, E, Canducci, F, Cantón, R, Capobianchi, M, Carattoli, A, Carcopino, X, Cardona-Castro, N, Carling, PC, Carrat, F, Castilla, J, Castilletti, C, Cavaco, L, Cavallo, R, Ceccherini-Silberstein, F, Centrón, D, Chappuis, F, Charrel, R, Chen, M, Chevaliez, S, Chezzi, C, Chomel, B, Chowers, M, Chryssanthou, E, Ciammaruconi, A, Ciccozzi, M, Cid, J, Ciofu, O, Cisneros, D, Ciufolini, MG, Clark, C, Clarke, SC, Clayton, R, Clementi, M, Clemons, K, Cloeckaert, Ael, Cloud, J, Coenye, T, Cohen Bacri, S, Cohen, R, Coia, J, Colombo, A, Colson, P, Concerse, P, Cordonnier, C, Cormican, M, Cornaglia, G, Cornely, O, Costa, S, Cots, F, Craxi, A, Creti, R, Crnich, C, Cuenca Estrella, M, Cusi, MG, d'Ettorre, G, da Cruz Lamas, C, Daikos, G, Dannaoui, E, De Barbeyrac, B, De Grazia, S, de Jager, C, de Lamballerie, X, de Marco, F, del Palacio, A, Delpeyroux, F, Denamur, E, Denis, O, Depaquit, J, Deplano, A, Desenclos, J-C, Desjeux, P, Deutch, S, Di Luca, D, Dianzani, F, Diep, B, Diestra, K, Dignani, C, Dimopoulos, G, Divizia, M, Doi, Y, Dornbusch, HJ, Dotis, J, Drancourt, M, Drevinek, P, Dromer, F, Dryden, M, Dubreuil, L, Dubus, J-C, Dumitrescu, O, Dumke, R, DuPont, H, Edelstein, M, Eggimann, P, Eis-Huebinger, A-M, El Atrouni, WI, Entenza, J, Ergonul, O, Espinel-Ingroff, A, Esteban, J, Etienne, J, Fan, X-G, Fenollar, F, Ferrante, P, Ferrieri, P, Ferry, T, Feuchtinger, T, Finegold, S, Fingerle, V, Fitch, M, Fitzgerald, R, Flori, P, Fluit, A, Fontana, R, Fournier, PE, François, M, Francois, P, Freedman, DO, Friedrich, A, Gallego, L, Gallinella, G, Gangneux, J-P, Gannon, V, Garbarg-Chenon, A, Garbino, J, Garnacho-Montero, J, Gatermann, Soeren, Gautret, P, Gentile, G, Gerlich, W, Ghannoum, M, Ghebremedhin, B, Ghigo, E, Giamarellos-Bourboulis, E, Girgis, R, Giske, C, Glupczynski, Y, Gnarpe, J, Gomez-Barrena, E, Gorwitz, RJ, Gosselin, R, Goubau, P, Gould, E, Gradel, K, Gray, J, Gregson, D, Greub, G, Grijalva, CG, Groll, A, Groschup, M, Gutiérrez, J, Hackam, DG, Hall, WA, Hallett, R, Hansen, S, Harbarth, S, Harf-Monteil, C, Hasanjani, Roushan MR, Hasler, P, Hatchette, T, Hauser, P, He, Q, Hedges, A, Helbig, J, Hennequin, C, Herrmann, B, Hezode, C, Higgins, P, Hoesli, I, Hoiby, N, Hope, W, Houvinen, P, Hsu, LY, Huard, R, Humphreys, H, Icardi, M, Imoehl, M, Ivanova, K, Iwamoto, T, Izopet, J, Jackson, Y, Jacobsen, K, Jang, TN, Jasir, A, Jaulhac, B, Jaureguy, F, Jefferies, JM, Jehl, F, Johnstone, J, Joly-Guillou, M-L, Jonas, M, Jones, M, Joukhadar, C, Kahl, B, Kaier, K, Kaiser, L, Kato, H, Katragkou, A, Kearns, A, Kern, W, Kerr, K, Kessin, R, Kibbler, C, Kimberlin, D, Kittang, B, Klaassen, C, Kluytmans, J, Ko, W-C, Koh, W-J, Kostrzewa, M, Kourbeti, I, Krause, R, Krcmery, V, Krizova, P, Kuijper, E, Kullberg, B-J, Kumar, G, Kunin, CM, La Scola, B, Lagging, M, Lagrou, K, Lamagni, T, Landini, P, Landman, D, Larsen, A, Lass-Floerl, C, Laupland, K, Lavigne, JP, Leblebicioglu, H, Lee, B, Lee, CH, Leggat, P, Lehours, P, Leibovici, Lonard, Leon, L, Leonard, N, Leone, M, Lescure, X, Lesprit, P, Levy, PY, Lew, D, Lexau, CA, Li, S-Y, Li, W, Lieberman, D, Lina, B, Lina, G, Lindsay, JA, Livermore, D, Lorente, L, Lortholary, O, Lucet, J-C, Lund, B, Lütticken, R, MacLeod, C, Madhi, S, Maertens, J, Maggi, F, Maiden, M, Maillard, J-Y, Maira-Litran, T, Maltezou, H, Manian, FA, Mantadakis, E, Maragakis, L, Marcelin, A-G, Marchaim, D, Marchetti, O, Marcos, M, Markotic, A, Martina, B, Martínez, J, Martinez, J-L, Marty, F, Maurin, M, McGee, L, Mediannikov, O, Meersseman, W, Megraud, F, Meletiadis, J, Mellmann, A, Meyer, E, Meyer, W, Meylan, P, Michalopoulos, A, Micol, R, Midulla, F, Mikami, Y, Miller, RF, Miragaia, M, Miriagou, V, Mitchell, TJ, Miyakis, S, Mokrousov, I, Monecke, S, Mönkemüller, K, Monno, L, Monod, M, Morales, G, Moriarty, F, Morosini, I, Mortensen, E, Mubarak, K, Mueller, B, Mühlemann, K, Muñoz Bellido, JL, Murray, P, Muscillo, M, Mylotte, J, Naessens, A, Nagy, E, Nahm, MH, Nassif, X, Navarro, D, Navarro, F, Neofytos, D, Nes, I, Ní Eidhin, D, Nicolle, L, Niederman, MS, Nigro, G, Nimmo, G, Nordmann, P, Nougairède, A, Novais, A, Nygard, K, Oliveira, D, Orth, D, Ortiz, JR, Osherov, N, Österblad, M, Ostrosky-Zeichner, L, Pagano, L, Palamara, AT, Pallares, R, Panagopoulou, P, Pandey, P, Panepinto, J, Pappas, G, Parkins, M, Parola, P, Pasqualotto, A, Pasteran, F, Paul, M, Pawlotsky, J-M, Peeters, M, Peixe, L, Pepin, J, Peralta, G, Pereyre, S, Perfect, JR, Petinaki, E, Petric, M, Pettigrew, M, Pfaller, M, Philipp, M, Phillips, G, Pichichero, M, Pierangeli, A, Pierard, D, Pigrau, C, Pilishvili, T, Pinto, F, Pistello, M, Pitout, J, Poirel, L, Poli, G, Poppert, S, Posfay-Barbe, K, Pothier, P, Poxton, I, Poyart, C, Pozzetto, B, Pujol, M, Pulcini, C, Punyadeera, C, Ramirez, M, Ranque, S, Raoult, D, Rasigade, J-P, Re, MC, Reilly, JS, Reinert, R, Renaud, B, Rice, L, Rich, S, Richet, H, Rigouts, L, Riva, E, Rizzo, C, Robotham, J, Rodicio, MR, Rodriguez, J, Rodriguez-Bano, J, Rogier, C, Roilides, E, Rolain, J-M, Rooijakkers, S, Rooney, P, Rossi, F, Rotimi, V, Rottman, M, Roux, V, Ruhe, J, Russo, G, Sadowy, E, Sagel, U, Said, SI, Saijo, M, Sak, B, Sa-Leao, R, Sanders, EAM, Sanguinetti, M, Sarrazin, C, Savelkoul, P, Scheifele, D, Schmidt, W-P, Schønheyder, H, Schönrich, G, Schrenzel, J, Schubert, S, Schwarz, K, Schwarz, S, Sefton, A, Segondy, M, Seifert, H, Seng, P, Senneville, E, Sexton, D, Shafer, RW, Shalit, I, Shankar, N, Shata, TM, Shields, J, Sibley, C, Sicinschi, L, Siljander, T, Simitsopoulou, M, Simoons-Smit, AM, Sissoko, D, Sjögren, J, Skiada, A, Skoczynska, A, Skov, R, Slack, M, Sogaard, M, Sola, C, Soriano, A, Sotto, A, Sougakoff, W, Souli, M, Spelberg, B, Spelman, D, Spiliopoulou, I, Springer, B, Stefani, S, Stein, A, Steinbach, WJ, Steinbakk, M, Strakova, L, Strenger, V, Sturm, P, Sullivan, P, Sutton, D, Symmons, D, Tacconelli, E, Tamalet, C, Tang, JW, Tang, Y-W, Tattevin, P, Thibault, V, Thomsen, RW, Thuny, F, Tong, S, Torres, C, Townsend, R, Tristan, A, Trouillet, J-L, Tsai, H-C, Tsitsopoulos, P, Tuerlinckx, D, Tulkens, P, Tumbarello, M, Tureen, J, Turnidge, JD, Turriziani, O, Tutuian, R, Uçkay, I, Upton, M, Vabret, A, Vamvakas, EC, van den Boom, D, Van Eldere, J, van Leeuwen, W, van Strijp, J, Van Veen, S, Vandamme, P, Vandenesch, F, Vayssier, M, Velin, D, Venditti, M, Venter, M, Venuti, A, Vergnaud, G, Verheij, T, Verhofstede, C, Viscoli, C, Vizza, CD, Vogel, U, Waller, A, Wang, YF, Warn, P, Warris, A, Wauters, G, Weidmann, M, Weill, F-X, Weinberger, M, Welch, D, Wellinghausen, N, Wheat, J, Widmer, A, Wild, F, Willems, R, Willinger, B, Winstanley, C, Witte, W, Wolff, M, Wong, F, Wootton, M, Wyllie, D, Xu, W, Yamamoto, S, Yaron, S, Yildirim, I, Zaoutis, T, Zazzi, M, Zbinden, R, Zehender, Gianguglielmo G, Zemlickova, H, Zerbini, ML, Zhang, L, Zhang, Y, Zhao, Y-D, Zhu, Z, and Zimmerli, W

Published
2011
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20. Migration experiences, life conditions, and drug use practices of Russian-speaking drug users who live in Paris: a mixed-method analysis from the ANRS-Coquelicot study.

Author

Tibi-Lévy, Yaël, Serebryakova, Daria, Jauffret-Roustide, Marie, ANRS-Coquelicot Study Group, Barin, F., Brunet, S., Chevaliez, S., Jauffret-Roustide, M., Léon, L., Le Strat, Y., Pawlotsky, J.-M., Pillonel, J., Semaille, C., Sommen, C., Soulier, A., Thierry, D., and Weill-Barillet, L.

Subjects
DRUG abuse, NEEDLE sharing, NEEDLE exchange programs, HIV infections, PHARMACEUTICAL policy, HARM reduction
Abstract

Background: After the collapse of the Soviet Union at the beginning of the 1990s, people who inject drugs spiked in Eastern Europe. Facing local repression and an array of factors encouraging emigration, some users have migrated to France. This population now make up to a third of the patient list of some harm reduction services in Paris. This article aims to present original data on the sociodemographic profiles of these users, on their migration trajectory, their life conditions, and on the evolution of their drug use practices since arriving in Paris. Methods: Data were collected as part of the ANRS-Coquelicot Survey, an HIV and HCV seroprevalence study among French-speaking people who use drugs. A sub-sample of Russian-speaking drug users who had relocated from Eastern Europe to live in Paris completed a quantitative questionnaire (N = 150) and a qualitative semi-structured interview (N = 20). The survey aimed to describe participants' backgrounds, and a thematic analysis of interviews was conducted to explore participants' migration histories, their life conditions in Paris, and their drug use practices before and after arriving in France. Results: This study highlights the great vulnerability of the participating population, often following a loss of social status after migrating to France. Another important finding is that participants had better access to harm reduction tools and reduced their risk of exposure to HIV and HCV infections linked to needle sharing. Although 60% said they had already shared a syringe in their lifetime (49.9% of them in their home country), the proportions shrank to 13.9% after they arrived in France and to 9.3% in the month before the study, a proportion that is lower than among French-speaking people who use drugs. Conclusions: Our main findings on the profiles and behaviors of the study population lead us to make two recommendations: to offer stronger global care to these users in Paris and to reform drug policy in their home countries by integrating it into a public health approach. [ABSTRACT FROM AUTHOR]

Published
2020
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21. Prévalence des infections par les virus des hépatites C (VHC) et B (VHB) et couverture vaccinale contre le VHB chez les hommes ayant des relations sexuelles avec des hommes fréquentant des lieux de convivialité gay de cinq villes françaises

Author

Vaux, S., primary, Chevaliez, S., additional, Saboni, L., additional, Sauvage, C., additional, Sommen, C., additional, Jauffret-Roustide, M., additional, Lot, F., additional, and Velter, A., additional

Published
2018
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23. Viral kinetics analysis and virological characterization of treatment failures in patients with chronic hepatitis C treated with sofosbuvir and an NS5A inhibitor

Author

Fourati, S., primary, Guedj, J., additional, Chevaliez, S., additional, Nguyen, T. H. T., additional, Roudot-Thoraval, F., additional, Ruiz, I., additional, Soulier, A., additional, Scoazec, G., additional, Varaut, A., additional, Poiteau, L., additional, Francois, M., additional, Mallat, A., additional, Hézode, C., additional, and Pawlotsky, J.-M., additional

Published
2017
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24. Efficacy, safety and patient‐reported outcomes of ledipasvir/sofosbuvir in NS3/4A protease inhibitor‐experienced individuals with hepatitis C virus genotype 1 and HIV coinfection with and without cirrhosis (ANRS HC31 SOFTRIH study)

Author

Rosenthal, E, primary, Fougerou‐Leurent, C, additional, Renault, A, additional, Carrieri, MP, additional, Marcellin, F, additional, Garraffo, R, additional, Teicher, E, additional, Aumaitre, H, additional, Lacombe, K, additional, Bailly, F, additional, Billaud, E, additional, Chevaliez, S, additional, Dominguez, S, additional, Valantin, MA, additional, Reynes, J, additional, Naqvi, A, additional, Cotte, L, additional, Metivier, S, additional, Leroy, V, additional, Dupon, M, additional, Allegre, T, additional, De Truchis, P, additional, Jeantils, V, additional, Chas, J, additional, Salmon‐Ceron, D, additional, Morlat, P, additional, Neau, D, additional, Perré, P, additional, Piroth, L, additional, Pol, S, additional, Bourlière, M, additional, Pageaux, GP, additional, Alric, L, additional, Zucman, D, additional, Girard, PM, additional, Poizot‐Martin, I, additional, Yazdanpanah, Y, additional, Raffi, F, additional, Pabic, E Le, additional, Tual, C, additional, Pailhé, A, additional, Amri, I, additional, Bellissant, E, additional, and Molina, JM, additional

Published
2017
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29. Age- and time-dependent prevalence and incidence of hepatitis C virus infection in drug users in France, 2004–2011: model-based estimation from two national cross-sectional serosurveys

Author

LEON, L., primary, KASEREKA, S., additional, BARIN, F., additional, LARSEN, C., additional, WEILL-BARILLET, L., additional, PASCAL, X., additional, CHEVALIEZ, S., additional, PILLONEL, J., additional, JAUFFRET-ROUSTIDE, M., additional, and LE STRAT, Y., additional

Published
2016
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30. Multicenter clinical evaluation of the new 3rd generation assay for detection of antibodies against hepatitis C virus on the VIDAS® system

Author

Seignères, B., primary, Descamps, F., additional, Croise, R., additional, Barlet, V., additional, Bouvier-Alias, M., additional, Chevaliez, S., additional, Pawlotsky, J.M., additional, Abdelhady, W., additional, Rafik, M., additional, Avellon, A.M., additional, Echevarria, J.M., additional, Hausmann, M., additional, and Dugua, J.-M., additional

Published
2016
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32. Ledipasvir/Sofosbuvir in NS3/4A Protease Inhibitor-Experienced Subjects with HCV Genotype 1 and HIV-Co-Infection Final Results of the ANRS HC31 Softrih Study

Author

Rosenthal, E., primary, Fougerou-Leurent, C., additional, Renault, A., additional, Teicher, E., additional, Dominguez, S., additional, Naqvi, A., additional, Metivier, S., additional, Cotte, L., additional, Reynes, J., additional, Valantin, M.-A., additional, Leroy, V., additional, Pageaux, G.-P., additional, Pol, S., additional, Piroth, L., additional, Perre, P., additional, Morlat, P., additional, Salmon-Ceron, D., additional, Chas, J., additional, Jeantils, V., additional, de Truchis, P., additional, Allègre, T., additional, Dupon, M., additional, Raffi, F., additional, Yazdanpanah, Y., additional, Poizot-Martin, I., additional, Neau, D., additional, Girard, P.-M., additional, Zucman, D., additional, Garraffo, R., additional, Chevaliez, S., additional, Carrieri, P., additional, Aumaitre, H., additional, Lacombe, K., additional, Bailly, F., additional, Billaud, E., additional, Pailhé, A., additional, Amri, I., additional, Bourlière, M., additional, Bellissant, E., additional, and Molina, J.-M., additional

Published
2016
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37. P0767 : Clinical utility of hepatitis C virus core antigen testing in the monitoring of treatment naïve non-cirrhotic patients receiving an all-oral, interferon-free regimien

Author

Cloherty, G., primary, Cheng, K., additional, Chevaliez, S., additional, Wedemeyer, H., additional, Sarrazin, C., additional, Feld, J., additional, Maasoumy, B., additional, Herman, C., additional, Hackett, J., additional, Dawson, G., additional, and Pawlotsky, J.M., additional

Published
2015
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38. Improved molecular laboratory productivity by consolidation of testing on the new random-access analyzer Alinity m

Author

Obermeier Martin, Pacenti Monia, Ehret Robert, Onelia Francesco, Gunson Rory, Goldstein Emily, Chevaliez Stéphane, Vilas Alba, Glass Allison, Maree Leana, Krügel Maria, Knechten Heribert, Braun Patrick, Naeth Gudrun, Azzato Francesca, Lucic Danijela, Marlowe Natalia, Palm Michael John, Pfeifer Karin, Reinhardt Birgit, Dhein Jens, Joseph Ajith Mathew, Martínez-García Laura, and Galán Juan-Carlos

Subjects
diagnosis, lab automation, molecular assay, turnaround time, workflow, Medical technology, R855-855.5
Abstract

Automated molecular analyzers have accelerated diagnosis, allowing earlier intervention and better patient follow-up. A recently developed completely automated molecular analyzer, Alinity™ m (Abbott), offers consolidated, continuous, and random-access testing that may improve molecular laboratory workflow.

Published
2020
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40. SAT-149 - Ledipasvir/Sofosbuvir in NS3/4A Protease Inhibitor-Experienced Subjects with HCV Genotype 1 and HIV-Co-Infection Final Results of the ANRS HC31 Softrih Study

Author

Rosenthal, E., Fougerou-Leurent, C., Renault, A., Teicher, E., Dominguez, S., Naqvi, A., Metivier, S., Cotte, L., Reynes, J., Valantin, M.-A., Leroy, V., Pageaux, G.-P., Pol, S., Piroth, L., Perre, P., Morlat, P., Salmon-Ceron, D., Chas, J., Jeantils, V., de Truchis, P., Allègre, T., Dupon, M., Raffi, F., Yazdanpanah, Y., Poizot-Martin, I., Neau, D., Girard, P.-M., Zucman, D., Garraffo, R., Chevaliez, S., Carrieri, P., Aumaitre, H., Lacombe, K., Bailly, F., Billaud, E., Pailhé, A., Amri, I., Bourlière, M., Bellissant, E., and Molina, J.-M.

Published
2016
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45. Multicenter Quality Control of Hepatitis C Virus Protease Inhibitor Resistance Genotyping

Author

Vallet, S., primary, Larrat, S., additional, Laperche, S., additional, Le Guillou-Guillemette, H., additional, Legrand-Abravanel, F., additional, Bouchardeau, F., additional, Pivert, A., additional, Henquell, C., additional, Mirand, A., additional, Andre-Garnier, E., additional, Giordanengo, V., additional, Lagathu, G., additional, Thibault, V., additional, Scholtes, C., additional, Schvoerer, E., additional, Gaudy-Graffin, C., additional, Maylin, S., additional, Trimoulet, P., additional, Brochot, E., additional, Hantz, S., additional, Gozlan, J., additional, Roque-Afonso, A.-M., additional, Soussan, P., additional, Plantier, J.-C., additional, Charpentier, C., additional, Chevaliez, S., additional, Colson, P., additional, Mackiewicz, V., additional, Aguilera, L., additional, Rosec, S., additional, Gouriou, S., additional, Magnat, N., additional, Lunel-Fabiani, F., additional, Izopet, J., additional, Morand, P., additional, Payan, C., additional, and Pawlotsky, J.-M., additional

Published
2013
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