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4. Small and Medium Building Efficiency Toolkit and Community Demonstration Program

Author

Kloss, M, Kloss, M, Piette, M, Hong, T, Fisk, W, Bourassa, N, Chan, W, Chen, Y, Cheung, I, Hotchi, T, Lee, S, Price, P, Schetrit, O, Sun, K, Taylor-Lange, S, Zhang, R, Kloss, M, Kloss, M, Piette, M, Hong, T, Fisk, W, Bourassa, N, Chan, W, Chen, Y, Cheung, I, Hotchi, T, Lee, S, Price, P, Schetrit, O, Sun, K, Taylor-Lange, S, and Zhang, R

Published
2023

10. Applicability of Electrical and Electroanalytical Techniques to Detect Water and Characterize the Geochemistry of Undisturbed Planetary Soils

Author

Seshadri, S, Buehler, M. G, Anderson, R. C, Kuhlman, G. M, Keymeulen, D, Cheung, I. W, and Schaap, M. G

Subjects
Lunar And Planetary Science And Exploration
Abstract

The search for life is a primary goal of NASA s planetary exploration program. The search is, of necessity, tiered in both the detection approach (looking for evidence of microbial fossils or the presence of water in the geological history of a planetary body and/or looking for evidence of water, energy sources, precursors to life, signatures of life and/or life itself in the present day planetary environment) and in the survey method (scale, range, specificity) employed. Terrestrial investigations suggests that life as we know it requires water. Thus, the search for extant microbial life and habitats requires identifying water-bearing soils. Determining Reduction-Oxidation (REDOX) couples present in water, once it is found, provides information on soil geochemistry and identifies potential chemical energy sources for life. Mars offers a near-term target for conducting this search. The identification of gully formation [1], layered deposits [2] and elemental ratios of bromine and chlorine [3] present indirect evidence that water was abundant locally in the Martian past. Additionally, Viking images of polar ice and frost formation on the surface of Mars demonstrate that water can exist in at least some near-surface regions of present-day Mars. Atmospheric pressure data further suggest that liquid water may be stable for short periods of time in the mid-latitudes of the Martian surface. [4] Measurements of the global distribution of hydrogen in the Martian regolith offer tantalizing indirect evidence that water may at least exist in near-surface soils. [5] Evidently, any water to be found is likely to exist as soil mixtures at levels ranging between approx.0.5% and approx.5 %.

Published
2005

12. Search for new phenomena with multiple charged leptons in proton-proton collisions at s=13TeV

Author

Khachatryan, V., Sirunyan, A. M., Tumasyan, A., Adam, W., Asilar, E., Bergauer, T., Brandstetter, J., Brondolin, E., Dragicevic, M., Eroe, J., Flechl, M., Friedl, M., Fruethwirth, R., Ghete, V. M., Hartl, C., Hoermann, N., Hrubec, J., Jeitler, M., Koenig, A., Kraetschmer, I., Liko, D., Matsushita, T., Mikulcc, I., Rabady, D., Rad, N., Rahbaran, B., Rohringer, H., Schieck, J., Strauss, J., Waltenberger, W., Wulz, C. -. E., Dvornikov, O., Makarenko, V., Zykunov, V., Mossolov, V., Shumeiko, N., Gonzalez, J. Suarez, Alderweireldt, S., De Wolf, E. A., Janssen, X., Lauwers, J., Van De Klundert, M., Van Haevermaet, H., Van Mechelen, P., Van Remortel, N., Van Spilbeeck, A., Abu Zeid, S., Blekman, F., D'Hondt, J., Daci, N., De Bruyn, I., Deroover, K., Lowette, S., Moortgat, S., Moreels, L., Olbrechts, A., Python, Q., Tavernier, S., Van Doninck, W., Van Mulders, P., Van Parijs, I., Brun, H., Clerbaux, B., De Lentdecker, G., Delannoy, H., Fasanella, G., Favart, L., Goldouzian, R., Grebenyuk, A., Karapostoli, G., Lenzi, T., Leonard, A., Luetic, J., Maerschalk, T., Marinov, A., Randle-conde, A., Seva, T., Van der Velde, C., Vanlaer, P., Yonamine, R., Zenoni, F., Zhang, F., Cimmino, A., Cornelis, T., Dobur, D., Fagot, A., Garcia, G., Gul, M., Khvastunov, I., Poyraz, D., Salva, S., Schofbeck, R., Sharma, A., Tytgat, M., Van Driessche, W., Yazgan, E., Zaganidis, N., Bakhshiansohi, H., Beluffi, C., Bondu, O., Brochet, S., Bruno, G., Caudron, A., De Visscher, S., Delaere, C., Delcourt, M., Francois, B., Giammanco, A., Jafari, A., Jez, P., Komm, M., Lemaitre, V., Magitteri, A., Mertens, A., Musich, M., Nuttens, C., Piotrzkowski, K., Quertenmont, L., Selvaggi, M., Marono, M. Vidal, Wertz, S., Beliy, N., Alda Junior, W. L., Alves, F. L., Alves, G. A., Brito, L., Hensel, C., Moraes, A., Pol, M. E., Teles, P. Rebello, Belchior Batista Das Chagas, E., Carvalho, W., Chinellato, J., Custodio, A., Da Costa, E. M., Da Silveira, G. G., De Jesus Damiao, D., De Oliveira Martins, C., Fonseca De Souza, S., Huertas Guativa, L. M., Malbouisson, H., Matos Figueiredo, D., Mora Herrera, C., Mundim, L., Nogima, H., Prado Da Silva, W. L., Santoro, A., Sznajder, A., Tonelli Manganote, E. J., Vilela Pereira, A., Ahuja, S., Bernardes, C. A., Dogra, S., Fernandez Perez Tomei, T. R., Gregores, E. M., Mercadante, P. G., Moon, C. S., Novaes, S. F., Padula, Sandra S., Romero Abad, D., Ruiz Vargas, J. C., Aleksandrov, A., Hadjiiska, R., Iaydjiev, P., Rodozov, M., Stoykova, S., Sultanov, G., Vutova, M., Dimitrov, A., Glushkov, I., Litov, L., Pavlov, B., Petkov, P., Fang, W., Ahmad, M., Bian, J. G., Chen, G. M., Chen, H. S., Chen, M., Chen, Y., Cheng, T., Jiang, C. H., Leggat, D., Liu, Z., Romeo, F., Shaheen, S. M., Spiezia, A., Tao, J., Wang, C., Wang, Z., Zhang, H., Zhao, J., Ban, Y., Chen, G., Li, Q., Liu, S., Mao, Y., Qian, S. J., Wang, D., Xu, Z., Avila, C., Cabrera, A., Sierra, L. F. Chaparro, Florez, C., Gomez, J. P., Gonzalez Hernandez, C. F., Ruiz Alvarez, J. D., Sanabria, J. C., Godinovic, N., Lelas, D., Puljak, I., Cipriano, P. M. Ribeiro, Sculac, T., Antunovic, Z., Kovac, M., Brigljevic, V., Ferencek, D., Kadija, K., Micanovic, S., Sudic, L., Susa, T., Attikis, A., Mavromanolakis, G., Mousa, J., Nicolaou, C., Ptochos, F., Razis, P. A., Rykaczewski, H., Tsiakkouri, D., Finger, M., J. r., Carrera Jarrin, E., Assran, Y., Elkafrawy, T., Khalil, S., Calpas, B., Kadastik, M., Murumaa, M., Perrini, L., Raidal, M., Tiko, A., Veelken, C., Eerola, P., Pekkanen, J., Voutilainen, M., Harkonen, J., Jarvinen, T., Karimaki, V., Kinnunen, R., Lampen, T., Lassila-Perini, K., Lehti, S., Linden, T., Luukka, P., Tuominiemi, J., Tuovinen, E., Wendland, L., Talvitie, J., Tuuva, T., Besancon, M., Couderc, F., Dejardin, M., Denegri, D., Fabbro, B., Faure, J. L., Favaro, C., Ferri, F., Ganjour, S., Ghosh, S., Givernaud, A., Gras, P., de Monchenault, G. Hamel, Jarry, P., Kucher, I., Locci, E., Machet, M., Malcles, J., Rander, J., Rosowsky, A., Titov, M., Zghiche, A., Abdulsalam, A., Antropov, I., Baffioni, S., Beaudette, F., Busson, P., Cadamuro, L., Chapon, E., Charlot, C., Davignon, O., de Cassagnac, R. Granier, Jo, M., Lisniak, S., Mine, P., Nguyen, M., Ochando, C., Ortona, G., Paganini, P., Pigard, P., Regnard, S., Salerno, R., Sirois, Y., Strebler, T., Yilmaz, Y., Zabi, A., Agram, J. -. L., Andrea, J., Aubin, A., Bloch, D., Brom, J. -. M., Buttignol, M., Chabert, E. C., Chanon, N., Collard, C., Conte, E., Coubez, X., Fontaine, J. -. C., Gele, D., Goerlach, U., Le Bihan, A. -. C., Skovpen, K., Van Hove, P., Gadrat, S., Beauceron, S., Bernet, C., Boudoul, G., Bouvier, E., Montoya, C. A. Carrillo, Chierici, R., Contardo, D., Courbon, B., Depasse, P., El Mamouni, H., Fan, J., Fay, J., Gascon, S., Gouzevitch, M., Grenier, G., Ille, B., Lagarde, F., Laktinch, I. B., Lethuillier, M., Mirabito, L., Pequegnot, A. L., Perries, S., Popov, A., Sabes, D., Sordini, V., Donckt, M. Vander, Verdier, P., Viret, S., Khvedelidze, A., Tsamalaidze, Z., Autermann, C., Beranek, S., Feld, L., Heister, A., Kiesel, M. K., Klein, K., Lipinski, M., Ostapchuk, A., Preuten, M., Raupach, F., Schael, S., Schomakers, C., Schulz, J., Verlage, T., Weber, H., Zhukov, V., Albert, A., Brodski, M., Dietz-Laursonn, E., Duchardt, D., Endres, M., Erdmann, M., Erdweg, S., Esch, T., Fischer, R., Gueth, A., Hamer, M., Hebbeker, T., Heidemann, C., Hoepfner, K., Knutzen, S., Merschmeyer, M., Meyer, A., Millet, P., Mukherjee, S., Olschewski, M., Padeken, K., Pook, T., Radziej, M., Reithler, H., Rieger, M., Scheuch, F., Sonnenschein, L., Teyssier, D., Thueer, S., Cherepanov, V., Fluegge, G., Hoehle, F., Kargoll, B., Kress, T., Kuensken, A., Lingemann, J., Mueller, T., Nehrkorn, A., Nowack, A., Nugent, I. M., Pistone, C., Pooth, O., Stahl, A., Martin, M. Aldaya, Arndt, T., Asawatangtrakuldee, C., Beernaert, K., Behnke, O., Behrens, U., Bin Anuar, A. A., Borras, K., Campbell, A., Connor, P., Contreras-Campana, C., Costanza, F., Pardos, C. Diez, Dolinska, G., Eckerlin, G., Eckstein, D., Eichhorn, T., Eren, E., Gallo, E., Garcia, J. Garay, Geiser, A., Gizhko, A., Luyando, J. M. Grados, Gunnellini, P., Harb, A., Hauk, J., Hempel, M., Jung, H., Kalogeropoulos, A., Karacheban, O., Kasemann, M., Keaveney, J., Kleinwort, C., Korol, I., Kruecker, D., Lange, W., Lelek, A., Leonard, J., Lipka, K., Lobanov, A., Lohmann, W., Mankel, R., Melzer-Pellmann, I. -. A., Meyer, A. B., Mittag, G., Mnich, J., Mussgiller, A., Ntomari, E., Pitzl, D., Placakyte, R., Raspereza, A., Roland, B., Sahin, M. O. e., Saxena, P., Schoerner-Sadenius, T., Seitz, C., Spannagel, S., Stefaniuk, N., Van Onsem, G. P., Walsh, R., Wissing, C., Blobel, V., Vignali, M. Centis, Draeger, A. R., Dreyer, T., Garutti, E., Gonzalez, D., Haller, J., Hoffmann, M., Junkes, A., Klanner, R., Kogler, R., Kovalchuk, N., Lapsien, T., Lenz, T., Marchesini, I., Marconi, D., Meyer, M., Niedziela, M., Nowatschin, D., Pantaleo, F., Peiffer, T., Perieanu, A., Poehlsen, J., Sander, C., Scharf, C., Schleper, P., Schmidt, A., Schumann, S., Schwandt, J., Stadie, H., Steinbrueck, G., Stober, F. M., Stoever, M., Tholen, H., Troendle, D., Usai, E., Vanelderen, L., Vanhoefer, A., Vormwald, B., Akbiyik, M., Barth, C., Baur, S., Baus, C., Berger, J., Butz, E., Caspart, R., Chwalek, T., Colombo, F., De Boer, W., Dierlamm, A., Fink, S., Freund, B., Friese, R., Giffels, M., Gilbert, A., Goldenzweig, P., Haitz, D., Hartmann, F., Heindl, S. M., Husemann, U., Katkov, I., Kudella, S., Pardo, P. Lobelle, Mildner, H., Mozer, M. U., Mueller, T. h., Plagge, M., Quast, G., Rabbertz, K., Roecker, S., Roscher, F., Schroeder, M., Shvetsov, I., Sieber, G., Simonis, H. J., Ulrich, R., Wagner-Kuhr, J., Wayand, S., Weber, M., Weiler, T., Williamson, S., Woehrmann, C., Wolf, R., Anagnostou, G., Daskalakis, G., Geralis, T., Giakournopoulou, V. A., Kyriakis, A., Loukas, D., Topsis-Giotis, I., Kesisoglou, S., Panagiotou, A., Saoulidou, N., Tziaferi, E., Evangelou, I., Flouris, G., Foudas, C., Kokkas, P., Loukas, N., Manthos, N., Papadopoulos, I., Paradas, E., Filipovic, N., Bencze, G., Hajdu, C., Hidas, P., Horvath, D., Sikler, F., Veszpremi, V., Vesztergombi, G., Zsigmond, A. J., Beni, N., Czellar, S., Karancsi, J., Makovec, A., Molnar, J., Szillasi, Z., Bartok, M., Raics, P., Trocsanyi, Z. L., Ujvari, B., Bahinipati, S., Choudhury, S., Mal, P., Mondal, K., Nayak, A., Sahoo, D. K., Sahoo, N., Swain, S. K., Bansal, S., Beri, S. B., Bhatnagar, V., Chawla, R., Bhawandeep, U., Kalsi, A. K., Kaur, A., Kaur, M., Kumar, R., Kumari, P., Mehta, A., Mittal, M., Singh, J. B., Walia, G., Kumar, Ashok, Bhardwaj, A., Choudhary, B. C., Garg, R. B., Keshri, S., Malhotra, S., Naimuddin, M., Nishu, N., Ranjan, K., Sharma, R., Sharma, V., Bhattacharya, R., Bhattacharya, S., Chatterjee, K., Dey, S., Dutt, S., Dutta, S., Majumdar, N., Modak, A., Mukhopadhyay, S., Nandan, S., Purohit, A., Roy, A., Roy, D., Chowdhury, S. Roy, Sarkar, S., Sharan, M., Thakur, S., Behera, P. K., Chudasama, R., Dutta, D., Jha, V., Kumar, V., Mohanty, A. K., Netrakanti, P. K., Pant, L. M., Shukla, P., Topkar, A., Aziz, T., Dugad, S., Kole, G., Mahakud, B., Mitra, S., Mohanty, G. B., Parida, B., Sur, N., Sutar, B., Banerjee, S., Bhowmik, S., Dewanjee, R. K., Ganguly, S., Guchait, M., Jain, S. a., Kumar, S., Maity, M., Majumder, G., Mazumdar, K., Sarkar, T., Wickramage, N., Chauhan, S., Dube, S., Hegde, V., Kapoor, A., Kothekar, K., Pandey, S., Rane, A., Sharma, S., Behnamian, H., Chenarani, S., Tadavani, E. Eskandari, Etesami, S. M., Fahim, A., Khakzad, M., Najafabadi, M. Mohammadi, Naseri, M., Mehdiabadi, S. Paktinat, Hosseinabadi, F. Rezaei, Safarzadeh, B., Zeinali, M., Felcini, M., Grunewald, M., Abbrescia, M., Calabria, C., Caputo, C., Colaleo, A., Creanza, D., Cristella, L., De Filippis, N., De Palma, M., Fiore, L., Iaselli, G., Maggi, G., Maggi, M., Miniello, G., My, S., Nuzzo, S., Pompili, A., Pugliese, G., Radogna, R., Ranieri, A., Selvaggi, G., Silvestris, L., Venditti, R., Verwilligen, P., Abbiendi, G., Battilana, C., Bonacorsi, D., Braibant-Giacomelli, S., Brigliadori, L., Campanini, R., Capiluppi, P., Castro, A., Cavallo, F. R., Chhibra, S. S., Codispoti, G., Cuffiani, M., Dallavalle, G. M., Fabbri, F., Fanfani, A., Fasanella, D., Giacomelli, P., Grandi, C., Guiducci, L., Marcellini, S., Masetti, G., Montanari, A., Navarria, F. L., Perrotta, A., Rossi, A. M., Rovelli, T., Siroli, G. P., Tosi, N., Albergo, S., Chiorboli, M., Costa, S., Di Mattia, A., Giordano, F., Potenza, R., Tricomi, A., Tuve, C., Barbagli, G., Ciulli, V., Civinini, C., D'Alessandro, R., Focardi, E., Gori, V., Lenzi, P., Meschini, M., Paoletti, S., Sguazzoni, G., Viliani, L., Benussi, L., Bianco, S., Piccolo, D., Primavera, F., Calvelli, V., Ferro, F., Lo Vetere, M., Monge, M. R., Robutti, E., Tosi, S., Brianza, L., Dinardo, M. E., Fiorendi, S., Gennai, S., Ghezzi, A., Govoni, P., Malberti, M., Malvezzi, S., Manzoni, R. A., Menasce, D., Moroni, L., Paganoni, M., Pedrini, D., Pigazzini, S., Ragazzi, S., de Fatis, T. Tabarelli, Buontempo, S., Cavallo, N., De Nardo, G., Di Guida, S., Esposito, M., Fabozzi, F., Fienga, F., Iorio, A. O. M., Lanza, G., Lista, L., Meola, S., Paolucci, P., Sciacca, C., Thyssen, F., Azzi, P., Bacchetta, N., Benato, L., Bisello, D., Boletti, A., Carlin, R., De Oliveira, A. Carvalho Antunes, Checchia, P., Dall'Osso, M., Manzano, P. De Castro, Dorigo, T., Dosselli, U., Gasparini, F., Gasparini, U., Gozzelino, A., Lacaprara, S., Margoni, M., Meneguzzo, A. T., Pazzini, J., Pozzobon, N., Ronchese, P., Simonetto, F., Torassa, E., Zanetti, M., Zotto, P., Zumerle, G., Braghieri, A., Magnani, A., Montagna, P., Ratti, S. P., Re, V., Riccardi, C., Salvini, P., Vai, I., Vitulo, P., Solestizi, L. Alunni, Bilei, G. M., Ciangottini, D., Fano, L., Lariccia, P., Leonardi, R., Mantovani, G., Menichelli, M., Saha, A., Santocchia, A., Androsov, K., Azzurri, P., Bagliesi, G., Bernardini, J., Boccali, T., Castaldi, R., Ciocci, M. A., Dell'Orso, R., Donato, S., Fedi, G., Giassi, A., Grippo, M. T., Ligabue, F., Lomtadze, T., Martini, L., Messineo, A., Palla, F., Rizzi, A., Savoy-Navarro, A., Spagnolo, P., Tenchini, R., Tonelli, G., Venturi, A., Verdini, P. G., Barone, L., Cavallari, F., Cipriani, M., Del Re, D., Diemoz, M., Gelli, S., Longo, E., Margaroli, F., Marzocchi, B., Meridiani, P., Organtini, G., Paramatti, R., Preiato, F., Rahatlou, S., Rovelli, C., Santanastasio, F., Amapane, N., Arcidiacono, R., Argiro, S., Arneodo, M., Bartosik, N., Bellan, R., Biino, C., Cartiglia, N., Cenna, F., Costa, M., Covarelli, R., Degano, A., Demaria, N., Finco, L., Kiani, B., Mariotti, C., Maselli, S., Migliore, E., Monaco, V., Monteil, E., Obertino, M. M., Pacher, L., Pastrone, N., Pelliccioni, M., Angioni, G. L. Pinna, Ravera, F., Romero, A., Ruspa, M., Sacchi, R., Shchelina, K., Sola, V., Solano, A., Staiano, A., Traczyk, P., Belforte, S., Casarsa, M., Cossutti, F., Della Ricca, G., Zanetti, A., Kim, D. H., Kim, G. N., Kim, M. S., Lee, S., Lee, S. W., Y. D., Oh, Sekmen, S., Son, D. C., Yang, Y. C., Lee, A., Kim, H., Cifuentes, J. A. Brochero, Kim, T. J., Cho, S., Choi, S., Go, Y., Gyun, D., Ha, S., Hong, B., Jo, Y., Kim, Y., Lee, B., Lee, K., Lee, K. S., Lim, J., Park, S. K., Roh, Y., Almond, J., Kim, J., Lee, H., S. B., Oh, Radburn-Smith, B. C., Seo, S. H., Yang, U. K., Yoo, H. D., G. B., Yu, Choi, M., Kim, J. H., Lee, J. S. H., Park, I. C., Ryu, G., Ryu, M. S., Choi, Y., Goh, J., Hwang, C., Lee, J., Yu, I., Dudenas, V., Juodagalvis, A., Vaitkus, J., Ahmed, I., Ibrahim, Z. A., Komaragiri, J. R., Ali, M. A. B. Md, Idris, F. Mohamad, Abdullah, W. A. T. Wan, Yusli, M. N., Zolkapli, Z., Castilla-Valdez, H., De La Cruz-Burelo, E., La Cruz, I. Heredia-De, Hernandez-Almada, A., Lopez-Fernandez, R., Magana Villalba, R., Mejia Guisao, J., Sanchez-Hernandez, A., Carrillo Moreno, S., Oropeza Barrera, C., Vazquez Valencia, F., Carpinteyro, S., Pedraza, I., Salazar Ibarguen, H. A., Uribe Estrada, C., Morelos Pineda, A., Krofcheck, D., Butler, P. H., Ahmad, A., Hassan, Q., Hoorani, H. R., Khan, W. A., Saddique, A., Shah, M. A., Shoaib, M., Waqas, M., Bialkowska, H., Bluj, M., Boimska, B., Frueboes, T., Gorski, M., Kazana, M., Nawrocki, K., Romanowska-Rybinska, K., Szleper, M., Zalewski, P., Bunkowski, K., Byszuk, A., Doroba, K., Kalinowski, A., Konecki, M., Krolikowski, J., Misiura, M., Olszewski, M., Walczak, M., Bargassa, P., Beirao Da Cruz E. Silva, C., Di Francesco, A., Faccioli, P., Ferreira Parracho, P. G., Gallinaro, M., Hollar, J., Leonardo, N., Iglesias, L. Lloret, Nemallapudi, M. V., Antunes, J. Rodrigues, Seixas, J., Toldaiev, O., Vadruccio, D., Varela, J., Vischia, P., Alexakhin, V., Golutvin, I., Gorbunov, I., Kamenev, A., Karjavin, V., Kozlov, G., Laney, A., Malakhov, A., Matveev, V., Palichik, V., Perelygin, V., Savina, M., Shmatov, S., Shulha, S., Skatchkov, N., Smirnov, V., Voytishin, N., Zarubin, A., Chtchipounov, L., Golovtsov, V., Ivanov, Y., Kim, V., Kuznetsova, E., Murzin, V., Oreshkin, V., Sulimov, V., Vorobyev, A., Andreev, Y. u., Dermenev, A., Gninenko, S., Golubev, N., Karneyeu, A., Kirsanov, M., Krasnikov, N., Pashenkov, A., Tlisov, D., Toropin, A., Epshteyn, V., Gavrilov, V., Lychkovskaya, N., Popov, V., Pozdnyakov, I., Safronov, G., Spiridonov, A., Toms, M., Vlasov, E., Zhokin, A., Bylinkin, A., Chadeeva, M., Markin, O., Tarkovskii, E., Andreev, V., Azarkin, M., Dremin, I., Kirakosyan, M., Leonidov, A., Rusakov, S. V., Terkulov, A., Baskakov, A., Belyaev, A., Boos, E., Dubinin, M., Dudko, L., Ershov, A., Gribushin, A., Klyukhin, V., Kodolova, O., Lokhtin, I., Miagkov, I., Obraztsov, S., Petrushanko, S., Savrin, V., Snigirev, A., Blinov, V., Skovpen, Y., Shtol, D., Azhgirey, I., Bayshev, I., Bitioukov, S., Elumakhov, D., Kachanov, V., Kalinin, A., Konstantinov, D., Krychkine, V., Petrov, V., Ryutin, R., Sobol, A., Troshin, S., Tyurin, N., Uzunian, A., Volkov, A., Adzic, P., Cirkovic, P., Devetak, D., Dordevic, M., Milosevic, J., Rekovic, V., Alcaraz Maestre, J., Barrio Luna, M., Calvo, E., Cerrada, M., Chamizo Llatas, M., Colino, N., De La Cruz, B., Delgado Peris, A., Escalante Del Valle, A., Fernandez Bedoya, C., Fernandez Ramos, J. P., Flix, J., Fouz, M. C., Garcia-Abia, P., Gonzalez Lopez, O., Goy Lopez, S., Hernandez, J. M., Josa, M. I., Navarro De Martino, E., Perez-Calero Yzquierdo, A., Puerta Pelayo, J., Quintario Olmeda, A., Redondo, I., Romero, L., Soares, M. S., de Troconiz, J. F., Missiroli, M., Moran, D., Cuevas, J., Fernandez Menendez, J., Gonzalez Caballero, I., Gonzalez Fernandez, J. R., Palencia Cortezon, E., Sanchez Cruz, S., Suarez Andres, I., Vizan Garcia, J. M., Cabrillo, I. J., Calderon, A., Castineiras De Saa, J. R., Curras, E., Fernandez, M., Garcia-Ferrero, J., Gomez, G., Lopez Virto, A., Marco, J., Martinez Rivero, C., Matorras, F., Piedra Gomez, J., Rodrigo, T., Ruiz-Jimeno, A., Scodellaro, L., Trevisani, N., Vila, I., Vilar Cortabitarte, R., Abbaneo, D., Auffray, E., Auzinger, G., Bachtis, M., Baillon, P., Ball, A. 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Subjects
PP COLLISIONS, SUPERGAUGE, Physics and Astronomy (miscellaneous), TRANSFORMATIONS, PRODUCTION CROSS-SECTION, ZZ PRODUCTION, MODEL, TEV, SUPERSYMMETRY, SQUARK, SUPERGRAVITY, EXTENSION, Engineering (miscellaneous)
Published
2017

15. Registered Replication Report

Author

Cheung, I., primary, Campbell, L., additional, LeBel, E. P., additional, Ackerman, R. A., additional, Aykutoğlu, B., additional, Bahník, Š., additional, Bowen, J. D., additional, Bredow, C. A., additional, Bromberg, C., additional, Caprariello, P. A., additional, Carcedo, R. J., additional, Carson, K. J., additional, Cobb, R. J., additional, Collins, N. L., additional, Corretti, C. A., additional, DiDonato, T. E., additional, Ellithorpe, C., additional, Fernández-Rouco, N., additional, Fuglestad, P. T., additional, Goldberg, R. M., additional, Golom, F. D., additional, Gündoğdu-Aktürk, E., additional, Hoplock, L. B., additional, Houdek, P., additional, Kane, H. S., additional, Kim, J. S., additional, Kraus, S., additional, Leone, C. T., additional, Li, N. P., additional, Logan, J. M., additional, Millman, R. D., additional, Morry, M. M., additional, Pink, J. C., additional, Ritchey, T., additional, Root Luna, L. M., additional, Sinclair, H. C., additional, Stinson, D. A., additional, Sucharyna, T. A., additional, Tidwell, N. D., additional, Uysal, A., additional, Vranka, M., additional, Winczewski, L. A., additional, and Yong, J. C., additional

Published
2016
Full Text
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16. Neuronal Kmt2a/Mll1 Histone Methyltransferase Is Essential for Prefrontal Synaptic Plasticity and Working Memory

Author

Jakovcevski, M., primary, Ruan, H., additional, Shen, E. Y., additional, Dincer, A., additional, Javidfar, B., additional, Ma, Q., additional, Peter, C. J., additional, Cheung, I., additional, Mitchell, A. C., additional, Jiang, Y., additional, Lin, C. L., additional, Pothula, V., additional, Stewart, A. F., additional, Ernst, P., additional, Yao, W.-D., additional, and Akbarian, S., additional

Published
2015
Full Text
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17. Far-infrared Raman laser based on resonant intersubband transitions

Author

Liu, Hui, Cheung, I., Springthorpe, Anthony, Dharma-Wardana, M, Wasilewski, Zbigniew, Lockwood, David, Aers, Geoffrey, and Cahay, M.

Abstract

200th Meeting of the Electrochemical Society, Symposium on Quantum Confinement, 2-7 September 2001, San Francisco

Published
2009

18. British society for matrix biology autumn meeting

Author

Sudre, L, Cheung, F, Kevorkian, L, Young, DA, Darrah, C, Donell, ST, Shepstone, L, Porter, S, Brockbank, S, Edwards, DR, Parker, AE, Clark, IM, Boubriak, OA, Urban, JPG, Cui, Z, Tew, SR, Li, Y, Tweats, LM, Hawkins, RE, Hardingham, TE, Green, D, Partridge, KA, Leveque, I, Mann, S, Oreffo, ROC, Ball, SG, Kielty, CM, Qin, M, Tai, G, Polak, JM, Bishop, AE, Stolzing, A, Scutt, A, Screen, HRC, Shelton, JC, Bader, DL, Lee, DA, Hall, A, Hayes, A, Brown, L, Tubo, R, Caterson, B, Blain, EJ, Gilbert, SJ, Duance, VC, Davies, L, Blain, E, Duance, V, Shengda, Z, Wu, M-H, Xu, X, Heywood, HK, Sims, T, Miot, S, Martin, I, Roughley, PJ, Soranzo, C, Pavesio, A, Hollander, AP, Yang, X, Webb, D, Blaker, J, Maquet, V, Boccaccini, AR, Cooper, C, Eves, P, Beck, AJ, Shard, AG, Gawkrodger, DJ, Mac Neil, S, Rajpar, MH, Kadler, KE, Thornton, DJ, Briggs, MD, Boot-Handford, RP, Ellis, MJ, Tai, C-C, Perera, S, Chaudhuri, JB, Callender, P, Mason, DJ, Colley, H, Mc Arthur, S, Mirmalek-Sani, SH, Roach, HI, Hanley, NA, Wilson, DI, MacIntosh, AC, Crawford, A, Hatton, PV, Wallis, G, Shah, R, Knowles, JC, Hunt, NP, Lewis, MP, Rippon, HJ, Ali, BE, De Bank, PA, Kellam, B, Shakesheff, KM, Comerford, EJ, Tarlton, JF, Wales, A, Bailey, AJ, Innes, JF, Olivier, V, Xie, Y, Descamps, M, Hivart, P, Lu, J, Hardouin, P, Anderson, V, Spiller, DG, Vaughan-Thomas, A, Eissa, SZS, Faram, T, Birch, HL, Zeugolis, D, Paul, G, Attenburrow, G, Bhadal, N, Whawell, SA, Worrall, LK, Rose, FRAJ, Bradshaw, TD, Stevens, MFG, Chuo, CB, Wiseman, MA, Phillips, JB, Brown, RA, Harrison, CA, Gossiel, F, Bullock, AJ, Blumsohn, A, Li, Z, Derham, B, Gaissmaier, C, Fritz, J, Krackhardt, T, Flesch, I, Aicher, WK, Ashammakhi, N, Liu, K-K, Yang, Y, Ahearne, M, Then, K, El Haj, A, Cheung, I, Wright, TC, Kostyuk, O, Baria, KE, Chowdhury, TT, Sharma, AM, Bomzon, Z, Kimmel, E, Knight, MM, Dickinson, S, Pittarello, L, Fish, RS, Ralphs, JR, Farjanel, J, Sève, S, Borel, A, Sommer, P, Hulmes, DJS, Whiting, CV, Dalton, SJ, Mitchell, DC, Kafienah, W, Mistry, S, Hollander, A, Cartmell, S, Magnay, J, Dobson, J, Appleby, RN, Salter, DM, Scutt, N, Rolf, CG, Barry, JJA, Nazhat, SN, Scotchford, CA, Howdle, SM, Roberts, S, Gargiulo, B, Evans, EH, Menage, J, Johnson, WEB, Eisenstein, S, Richardson, JB, Stenfeldt, C, Avery, NC, Tidswell, H, Crabtree, J, Frazer, A, Fraser, S, Wong, M, Beckett, K, Grobbelaar, A, Mudera, V, Bax, DV, Cain, SA, Humphries, MJ, Lomas, A, Oldershaw, R, Murdoch, A, Brennan, K, Redman, S, Haughton, L, Dowthwaite, G, Williams, A, Archer, CW, Esfandiari, E, Stokes, CR, Cox, TM, Evans, MJ, Bailey, M, Hayman, AR, Day, MJ, Williams, R, Evans, D, Adesida, A, Millwards-Sadler, J, Salter, D, Smith, R, Korda, M, Porter, R, Kalia, P, Wiseman, M, Blunn, G, Goodship, A, McClumpha, A, Horrocks, M, Pabbruwe, MB, Du, X, Stewart, K, Suciati, T, Lakey, RL, Pennington, CJ, Cawston, TE, Palmer, L, Tasman, C, Clare, M, Gidley, J, Sandy, J, Mansell, J, Ellis, T, Burger, F, Lauder, R, Khan, I, and Smith, M

Published
2005

19. Measurement properties of the UK-English version of the Pediatric Quality of Life Inventory™ 4.0 (PedsQL™) generic core scales\ud

Author

Upton, P., Eiser, C., Cheung, I., Hutchings, H.A., Jenney, M., Maddocks, A., Russell, I.T., and Williams, J.G.

Subjects
humanities
Abstract

Background\ud \ud Health related quality of life (HRQL) has been recognised as an important paediatric outcome measurement. One of the more promising measures to emerge in recent years is the Pediatric Quality Of Life Inventory (PedsQL™), developed in the US. Advantages of the PedsQL™ include brevity, availability of age appropriate versions and parallel forms for child and parent. This study developed a UK-English version of PedsQL™ generic module and assessed its performance in a group of UK children and their parents.\ud \ud Methods\ud \ud PedsQL™ was translated to UK-English. The psychometric properties of the UK version were then tested following administration to 1399 children and 970 of their parents. The sample included healthy children, children diagnosed with asthma, diabetes or inflammatory bowel disease and children in remission from cancer.\ud \ud Results\ud \ud Psychometric properties were similar to those reported for the original PedsQL™. Internal reliability exceeded 0.70 for all proxy and self-report sub-scales. Discriminant validity was established for proxy and self-report with higher HRQL being reported for healthy children than those with health problems. Sex differences were noted on the emotional functioning subscale, with females reporting lower HRQL than males. Proxy and self-report correlation was higher for children with health problems than for healthy children.\ud \ud Conclusion\ud \ud The UK-English version of PedsQL™ performed as well as the original PedsQL™ and is recommended for assessment of paediatric HRQL in the UK.\ud

Published
2005

21. Neuroblastic and Schwannian stromal cells of neuroblastoma are derived from a tumoral progenitor cell

Author

Mora J, Cheung, NKV, Juan, G, Illei, P, Cheung, I, Akram, M, Chi, S, Ladanyi, M, Cordon-Cardo, C, and Gerald, WL

Abstract

The coexistence of neuroblastic and Schwannian stromal (SS) cells in differentiating neuroblastoma (NB), and derivation of Schwannian-like cells from neuroblastic clones in vitro, were accepted previously as evidence of a common pluripotent tumor stem line. This paradigm was challenged when SS cells were suggested to be reactive in nature. The advent of microdissection techniques, PCR-based allelic analysis, and in situ fluorescent cytometry made possible the analysis of pure cell populations in fresh surgical specimens, allowing unequivocal determination of clonal origins of various cell subtypes. To overcome the complexity and heterogeneity of three-dimensional tissue structure, we used: (a) Laser-Capture Microdissection to obtain histologically homogeneous cell subtype populations for allelotype analysis at chromosomes 1p36, 11q23, 14q32, and 17q and study of MYCN copy number; (b) multiparametric analysis by Laser-Scanning Cytometry of morphology, DNA content, and immunophenotype of intact cells from touch imprints; and (c) bicolor fluorescence in situ hybridization on touch imprints from manually microdissected neuroblast and stroma-rich areas. Histologically distinct SS and neuroblastic cells isolated by Laser-Capture Microdissection had the same genetic composition in 27 of 28 NB analyzed by allelic imbalance and gene copy number. In all 20 cases studied by Laser-Scanning Cytometry, SS cells identified by morphology and S-100 immunostaining had identical DNA content and GD2-staining pattern as their neuroblastic counterparts. In 7 cases, fluorescence in situ hybridization demonstrated the same chromosomal makeup for SS and neuroblastic cells. These results provide unequivocal evidence that neuroblastic and SS cells in NB are derived from genetically identical neoplastic cells and support the classical paradigm that NB arises from tumoral cells capable of development along multiple lineages.

Published
2001

22. SP021 Bone marrow minimal residual disease (MRD) was the strongest predictor of survival from high risk metastatic neuroblastoma (NB) following anti-GD2 immunotherapy, when tested in multivariate models that include FcR polymorphism and missing ligand for inhibitory killer-immunoglobulin-like receptor (KIR)

Author

Cheung, N., primary, Cheung, I., additional, Kuk, D., additional, Ostrovnaya, I., additional, Modak, S., additional, Kramer, K., additional, and Kushner, B., additional

Published
2013
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23. Psychology and counselling

Author

Van Parys, H., primary, Wyverkens, E., additional, Provoost, V., additional, Ravelingien, A., additional, Raes, I., additional, Somers, S., additional, Stuyver, I., additional, De Sutter, P., additional, Pennings, G., additional, Buysse, A., additional, Anttila, V. S., additional, Salevaara, M., additional, Suikkari, A. M., additional, Listijono, D. R., additional, Mooney, S., additional, Chapman, M. G., additional, Res Muravec, U., additional, Pusica, S., additional, Lomsek, M., additional, Cizek Sajko, M., additional, Parames, S., additional, Semiao-Francisco, L., additional, Sato, H., additional, Ueno, J., additional, van den Wijngaard, L., additional, Mochtar, M. H., additional, van Dam, H., additional, van der Veen, F., additional, van Wely, M., additional, Derks-Smeets, I. A. P., additional, Habets, J. J. G., additional, Tibben, A., additional, Tjan-Heijnen, V. C. G., additional, Meijer-Hoogeveen, M., additional, Geraedts, J. P. M., additional, van Golde, R., additional, Gomez-Garcia, E., additional, de Die-Smulders, C. E. M., additional, van Osch, L. A. D. M., additional, Kets, C. M., additional, Gullo, S., additional, Donarelli, Z., additional, Coco, G. L., additional, Marino, A., additional, Volpes, A., additional, Sammartano, F., additional, Allegra, A., additional, Nekkebroeck, J., additional, Tournaye, H., additional, Stoop, D., additional, Lo Coco, G., additional, Coffaro, F., additional, Diaz, D. G., additional, Gonzalez, M. A., additional, Tirado, M., additional, Chamorro, S., additional, Dolz, P., additional, Gil, M. A., additional, Ballesteros, A., additional, Velilla, E., additional, Castello, C., additional, Moina, N., additional, Lopez-Teijon, M., additional, Chan, C. H. Y., additional, Chan, C. L. W., additional, Leong, M. K. H., additional, Cheung, I. K. M., additional, Chan, T. H. Y., additional, Hui, B. N. L., additional, van Dongen, A. J. C. M., additional, Huppelschoten, A. G., additional, Kremer, J. A. M., additional, Nelen, W. L. D. M., additional, Verhaak, C. M., additional, Sun, H. G., additional, Lee, K. H., additional, Park, I. H., additional, Kim, S. G., additional, Lee, J. H., additional, Kim, Y. Y., additional, Kim, H. J., additional, Cho, J. D., additional, Yoo, Y. J., additional, Frokjaer, V., additional, Pinborg, A., additional, Larsen, E. C., additional, Heede, M., additional, Stenbaek, D. S., additional, Henningsson, S., additional, Nielsen, A. P., additional, Svarer, C., additional, Holst, K. K., additional, Knudsen, G. M., additional, Emery, M., additional, DeJonckheere, L., additional, Rothen, S., additional, Wisard, M., additional, Germond, M., additional, Toftager, M., additional, Hjordt, L. V., additional, Jensen, P. S., additional, Holst, K., additional, Holland, T., additional, Bryndorf, T., additional, Bogstad, J., additional, Hornnes, P., additional, Frokjaer, V. G., additional, Dornelles, L. M. N., additional, MacCallum, F., additional, Lopes, R. C. S., additional, Piccinini, C. A., additional, Passos, E. P., additional, Bruegge, C., additional, Thorn, P., additional, Daniels, K., additional, Imrie, S., additional, Jadva, V., additional, Golombok, S., additional, Arens, Y., additional, De Krom, G., additional, Van Golde, R. J. T., additional, Coonen, E., additional, Van Ravenswaaij-Arts, C. M. A., additional, Evers, J. L. H., additional, De Die-Smulders, C. E. M., additional, Ghazeeri, G., additional, Awwad, J., additional, Fakih, A., additional, Abbas, H., additional, Harajly, S., additional, Tawidian, L., additional, Maalouf, F., additional, Ajdukovic, D., additional, Pibernik-Okanovic, M., additional, Alebic, M. S., additional, Baccino, G., additional, Calatayud, C., additional, Ricciarelli, E., additional, de Miguel, E. R. H., additional, Wierckx, K., additional, Verstraelen, H., additional, Van Glabeke, L., additional, Van den Abbeel, E., additional, Gerris, J., additional, T'Sjoen, G., additional, Monica, B., additional, Calonge, R. N., additional, Peregrin, P. C., additional, Cserepes, R., additional, Kollar, J., additional, Wischmann, T., additional, Bugan, A., additional, Pinkard, C., additional, Harrison, C., additional, Bunting, L., additional, Boivin, J., additional, Fulford, B., additional, Theusink-Kirchhoff, N., additional, van Ravenswaaij-Arts, C. M. A., additional, Bakker, M. K., additional, Volks, C., additional, Papaligoura, Z., additional, Papadatou, D., additional, Bellali, T. H., additional, Jarvholm, S., additional, Broberg, M., additional, Thurin-Kjellberg, A., additional, Weitzman, G., additional, Van Der Putten-Landau, T. M., additional, Chudnoff, S., additional, Panagopoulou, E., additional, Tarlatzis, B., additional, Tamhankar, V., additional, Jones, G. L., additional, Magill, P., additional, Skull, J. D., additional, Ledger, W., additional, Hvidman, H. W., additional, Specht, I. O., additional, Schmidt, K. T., additional, Andersen, A. N., additional, Freeman, T., additional, Zadeh, S., additional, Smith, V., additional, Whitaker, L. H. R., additional, Reid, J., additional, Wilson, J., additional, Critchley, H. O. D., additional, Horne, A. W., additional, Peterson, B., additional, Pirritano, M., additional, Schmidt, L., additional, Volgsten, H., additional, Van Parys, H., additional, Hudson, N., additional, Culley, L., additional, Law, C., additional, Denny, E., additional, Mitchell, H., additional, Baumgarten, M., additional, Raine-Fenning, N., additional, Blake, L., additional, and Kim, K. H., additional

Published
2013
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43. A mutational analysis of Caenorhabditis elegans in space

Author

Zhao, Y., Lai, K., Cheung, I., Youds, J., Tarailo, M., Tarailo, S., and Rose, A.

Abstract

The International Caenorhabditis elegans Experiment First Flight (ICE-First) was a project using C. elegans as a model organism to study the biological effects of short duration spaceflight (11 days in the International Space Station). As a member of the ICE-First research team, our group focused on the mutational effects of spaceflight. Several approaches were taken to measure mutational changes that occurred during the spaceflight including measurement of the integrity of poly-G/poly-C tracts, determination of the mutation frequency in the unc-22 gene, analysis of lethal mutations captured by the genetic balancer eT1(III;V), and identification of alterations in telomere length. By comparing the efficiency, sensitivity, and convenience of these methods, we deduced that the eT1 balancer system is well-suited for capturing, maintaining and recovering mutational events that occur over several generations during spaceflight. In the course of this experiment, we have extended the usefulness of the eT1 balancer system by identifying the physical breakpoints of the eT1 translocation and have developed a PCR assay to follow the eT1 chromosomes. C. elegans animals were grown in a defined liquid media during the spaceflight. This is the first analysis of genetic changes in C. elegans grown in the defined media. Although no significant difference in mutation rate was detected between spaceflight and control samples, which is not surprising given the short duration of the spaceflight, we demonstrate here the utility of worms as an integrating biological dosimeter for spaceflight.

Published
2006
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44. Hemolysin transport in Escherichia coli. Point mutants in HlyB compensate for a deletion in the predicted amphiphilic helix region of the HlyA signal.

Author

Sheps, J A, Cheung, I, and Ling, V

Abstract

The alpha-hemolysin transporter of Escherichia coli, a member of the ATP-binding cassette transporter super-family, is responsible for secretion of the 107-kDa protein toxin HlyA across both membranes of the Gram-negative envelope in a single step. Secretion of HlyA is dependent on a signal sequence, which occupies the C-terminal 50-60 amino acids of HlyA. Previously, it was shown that point mutants in the transmembrane domain of the transporter HlyB could partially correct the transport defect caused by a deletion of the C-terminal 29 amino acids of HlyA. These suppressor mutations demonstrated a direct interaction between HlyA and HlyB. They also displayed suppressor effects on a broad spectrum of HlyA signal mutants. In the present study, we selected HlyB alleles that complemented an internal deletion of 29 amino acids in HlyA containing a predicted amphiphilic helix region immediately upstream from the previous deletion. This set of HlyB mutants identifies further sites in HlyB that modulate substrate specificity but display allele-specific effects on a range of HlyA signal mutants. The inability to isolate mutations with effects restricted to either half of the signal sequence suggests that the signal is not recognized in a modular fashion by the transporter but rather functions as an integrated whole. We also report the isolation of the first substrate specificity mutation, which lies within the ATP-binding domain of HlyB. This could support a model in which the region of the ATP-binding cassette between the two Walker consensus motifs involved in ATP binding interacts with either the substrate or the transmembrane domains.

Published
1995

45. "Active" one-carbon generation in Saccharomyces cerevisiae

Author

Ogur, M, Liu, T N, Cheung, I, Paulavicius, I, Wales, W, Mehnert, D, and Blaise, D

Abstract

A new mutation introducing a one-carbon requirement (e.g., formate) for the glycine-supplemented growth of a serine-glycine auxotroph (ser1) was correlated with a lack of glycine decarboxylase activity. The presence of oxalate decarboxylase activity or glyoxylate decarboxylase activity did not overcome the one-carbon requirement. Another mutation characterized by the absence of oxalate decarboxylase activity did not introduce a one-carbon requirement. The presence and physiological significance of glycine decarboxylase activity in Saccharomyces are thus inferred.

Published
1977
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47. Measurement properties of the UK-English version of the Pediatric Quality of Life Inventory™ 4.0 (PedsQL™) generic core scales

Author

Maddocks Alison, Jenney Meriel, Hutchings Hayley A, Cheung Ivy, Eiser Christine, Upton Penney, Russell Ian T, and Williams John G

Subjects
Computer applications to medicine. Medical informatics, R858-859.7
Abstract

Abstract Background Health related quality of life (HRQL) has been recognised as an important paediatric outcome measurement. One of the more promising measures to emerge in recent years is the Pediatric Quality Of Life Inventory (PedsQL™), developed in the US. Advantages of the PedsQL™ include brevity, availability of age appropriate versions and parallel forms for child and parent. This study developed a UK-English version of PedsQL™ generic module and assessed its performance in a group of UK children and their parents. Methods PedsQL™ was translated to UK-English. The psychometric properties of the UK version were then tested following administration to 1399 children and 970 of their parents. The sample included healthy children, children diagnosed with asthma, diabetes or inflammatory bowel disease and children in remission from cancer. Results Psychometric properties were similar to those reported for the original PedsQL™. Internal reliability exceeded 0.70 for all proxy and self-report sub-scales. Discriminant validity was established for proxy and self-report with higher HRQL being reported for healthy children than those with health problems. Sex differences were noted on the emotional functioning subscale, with females reporting lower HRQL than males. Proxy and self-report correlation was higher for children with health problems than for healthy children. Conclusion The UK-English version of PedsQL™ performed as well as the original PedsQL™ and is recommended for assessment of paediatric HRQL in the UK.

Published
2005
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49. Potential use of Fourier-transform infrared spectroscopy as a rapid screening tool for investigating nosocomial outbreaks of ST-80 vancomycin-resistant Enterococcus faecium.

Author

Wong RCW, Cheung IYY, Lai CKC, Yuk MT, Chow VCY, Leung JSL, Chau NK, Konishi LK, Lee LK, Ng ICF, Tam WY, Tong JHC, and Siu GKH

Abstract

Background: Fourier-transform infrared (FT-IR) spectroscopy is a non-genomic, spectrum-based typing technology useful for characterizing outbreaks of multidrug-resistant organisms., Aim: To assess the performance of FT-IR spectroscopy in characterizing ST-80 vancomycin-resistant Enterococcus faecium (VREf) isolates from a nosocomial outbreak., Methods: Core-genome single-nucleotide polymorphism phylogeny was used as a reference method to characterize a nosocomial outbreak caused by ST-80 VREf. It identified 22 of 25 epidemiologically related isolates as belonging to an outbreak cluster., Findings: The use of FT-IR spectroscopy with a cluster-defining cut-off of 0.071 resulted in the correct classification of 21 out of 22 phylogenetically related isolates in a single cluster. It successfully distinguished three phylogenetically unrelated isolates from the outbreak cluster, along with five ST-80-unrelated control isolates, and five isolates from a previous outbreak in May 2023, yielding only one mischaracterized environmental isolate., Conclusion: These findings support the potential use of FT-IR spectroscopy as a rapid screening tool to assist outbreak investigations. Notably, this study is the first to focus on the performance of FT-IR spectroscopy in the epidemiological analysis of VREf isolates with the same sequence type., (Copyright © 2024 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.)

Published
2024
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50. RSV severity in New Zealand 2021 and 2022: applying the WHO severity assessment framework.

Author

Broderick D, Cheung I, Paynter J, O'Donnell J, Albrecht S, Aminisani N, Trenholme A, Grant CC, Huang S, Turner N, Byrnes CA, and McIntyre P

Abstract

Competing Interests: Janine Paynter received grant from GSK which paid to institution for research on pertussis epidemiology, and payment from CSL Seqirus for a seminar on observation study methodology. The rest authors declare no competing interests.

Published
2024
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