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16 results on '"Cheung, Pearl"'

2. Extensively methylated myosin subfragment-1: examination of local structure, interactions with nucleotides and actin, and ligand-induced conformational changes

Author

Phan, Brigitte C., Cheung, Pearl, Miller, Carl J., Reisler, Emil, and Muhlrad, Andras

Subjects
Myosin -- Research, Actin -- Analysis, Methylation -- Analysis, Biological sciences, Chemistry
Abstract

Far- and near UV circular dichroism spectra of extensively methylated myosin subfragment-1 (S1) show that methylation has no influence on the secondary structure but induces limited modifications in tertiary structure. Methylation decreases the interaction of S1 with actin and the affinity between actin-and nucleotide-binding sites. Methylation inhibits communication between various binding sites and the flawed communication is revealed by various parameters.

Published
1994

8. Extensively methylated myosin subfragment-1: Examination of local structure, interactions with...

Author

Chan, Brigitte P. and Cheung, Pearl

Subjects
*MYOSIN, *METHYLATION, *CIRCULAR dichroism
Abstract

Examines the effects of extensive methylation on myosin subfragment-1 (S1) structure and function using circular dichroism. Atomic structure of methylated S1; Secondary structure as unaffected by methylation; Cause of limited changes in the tertiary structure; Indication of flawed communications in methylated S1; Impairment of S1.

Published
1994
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16. Considerations in selecting postoperative analgesia for pregnant sheep following fetal instrumentation surgery

Author

Tamara J. Varcoe, Pearl Cheung, Mary J. Berry, Kathryn L. Gatford, Janna L. Morrison, Jack R. T. Darby, Michael D. Wiese, Stacey L. Holman, Varcoe, Tamara J, Darby, Jack RT, Gatford, Kathryn L, Holman, Stacey L, Cheung, Pearl, Berry, Mary J, Wiese, Michael D, and Morrison, Janna L

Subjects
0303 health sciences, Pregnancy, medicine.medical_specialty, Fetus, sheep, business.industry, MEDLINE, analgesia, medicine.disease, Feature Articles, 3. Good health, Surgery, surgery, 03 medical and health sciences, fetus, 0302 clinical medicine, Food Animals, medicine, Animal Science and Zoology, Instrumentation (computer programming), pregnancy, business, 030217 neurology & neurosurgery, 030304 developmental biology
Abstract

Implications • As a model of human pregnancy, research studies in catheterized fetal sheep have made significant contributions to our understanding of both normal and abnormal fetal development. • Owing to the invasive nature of catheterization surgery, effective postoperative analgesia is required. • Decisions regarding appropriate analgesia should consider effectiveness in reducing maternal pain and fetal well-being as well as potential impacts upon fetal physiological parameters under investigation. • The reporting of analgesic regimes in all research studies should comply with the ARRIVE guidelines Refereed/Peer-reviewed

Published
2019

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