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46 results on '"Cheung, Hoi Ching"'

2. Continuity of care during severe civil unrest with a model of community-based HIV care: a retrospective cohort study from Haiti

Author

Joseph, Patrice, Sun, Rochelle, Guiteau, Colette, Jean Juste, Marc Antoine, Dorvil, Nancy, Vilbrun, Stalz, Secours, Rode, Severe, Karine, Raymond, Parnel, Cetoute, Fernande, Baptiste, Wilnide Jean, Forestal, Guyrlaine, Cadet, Stanley, Marcelin, Adias, Deschamps, Marie Marcelle, McNairy, Margaret L., Dua, Akanksha, Cheung, Hoi Ching, Pape, Jean William, and Koenig, Serena P.

Published
2024
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8. High Rates of Retention and Viral Suppression with a Model of Community-Based HIV Care in a Setting of Severe Civil Unrest

Author

Joseph, Patrice, primary, Sun, Rochelle, additional, Guiteau, Colette, additional, Jean Juste, Marc Antoine, additional, Dorvil, Nancy, additional, Vilbrun, Stalz Charles, additional, Secours, Rode, additional, Severe, Karine, additional, Raymond, Parnel, additional, Cetoute, Fernande, additional, Jean Baptiste, Wilnide, additional, Forestal, Guyrlaine Pierre-Louis, additional, Cadet, Stanley, additional, Marcelin, Adias, additional, Deschamps, Marie Marcelle, additional, Dua, Akanksha, additional, Cheung, Hoi Ching, additional, Pape, Jean William, additional, and Koenig, Serena P., additional

Published
2024
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9. CTHRC1+ fibroblasts and SPP1+ macrophages synergistically contribute to pro-tumorigenic tumor microenvironment in pancreatic ductal adenocarcinoma.

Author

Li, Evan, Cheung, Hoi Ching, and Ma, Shuangge

Subjects
MYELOID cells, EPITHELIAL-mesenchymal transition, PANCREATIC duct, EXTRACELLULAR matrix, STROMAL cells
Abstract

Pancreatic ductal adenocarcinoma (PDAC) is an extremely lethal cancer that accounts for over 90% of all pancreatic cancer cases. With a 5-year survival rate of only 13%, PDAC has proven to be extremely desmoplastic and immunosuppressive to most current therapies, including chemotherapy and surgical resection. In recent years, focus has shifted to understanding the tumor microenvironment (TME) around PDAC, enabling a greater understanding of biological pathways and intercellular interactions that can ultimately lead to potential for future drug targets. In this study, we leverage a combination of single-cell and spatial transcriptomics to further identify cellular populations and interactions within the highly heterogeneous TME. We demonstrate that SPP1+APOE+ tumor-associated macrophages (TAM) and CTHRC1+GREM1+ cancer-associated myofibroblasts (myCAF) not only act synergistically to promote an immune-suppressive TME through active extracellular matrix (ECM) deposition and epithelial mesenchymal transition (EMT), but are spatially colocalized and correlated, leading to worse prognosis. Our results highlight the crosstalk between stromal and myeloid cells as a significant area of study for future therapeutic targets to treat cancer. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Profiling Disease and Economic Burden in CRSwNP Using Machine Learning

Author

Bhattacharyya,Neil, Silver,Jared, Bogart,Michael, Kponee-Shovein,Kalé, Cheng,Wendy Y, Cheng,Mu, Cheung,Hoi Ching, Duh,Mei Sheng, Hahn,Beth, Bhattacharyya,Neil, Silver,Jared, Bogart,Michael, Kponee-Shovein,Kalé, Cheng,Wendy Y, Cheng,Mu, Cheung,Hoi Ching, Duh,Mei Sheng, and Hahn,Beth

Abstract

Neil Bhattacharyya,1 Jared Silver,2 Michael Bogart,2 Kalé Kponee-Shovein,3 Wendy Y Cheng,3 Mu Cheng,3 Hoi Ching Cheung,3 Mei Sheng Duh,3 Beth Hahn2 1Mass Eye & Ear and Harvard Medical School, Boston, MA, USA; 2GSK, Durham, NC, USA; 3Analysis Group, Boston, MA, USACorrespondence: Neil Bhattacharyya, Mass Eye & Ear and Harvard Medical School, 243 Charles St, Boston, MA, 02114, USA, Tel +1 617-936-6118, Fax +1 617-936-6170, Email neiloy@bhattacharyya.orgPurpose: Chronic rhinosinusitis with nasal polyps (CRSwNP) is associated with high healthcare resource utilization (HRU) and economic cost; however, heterogeneity of clinical burden among patients with differing clinical characteristics has not been fully elucidated. Here, an unsupervised machine learning approach supported by clinical validation identified distinct clusters of patients with CRSwNP and compared healthcare burden.Patients and Methods: This retrospective analysis identified adult patients with ≥ 2 claims for CRSwNP and date of first diagnosis (index date) between January 2015 and June 2019 from a healthcare database. Patients were required to have enrollment in the database 6-months pre- and 12-months post-index. Patients were assigned to clusters using latent class analysis. All-cause and nasal polyp (NP)-related HRU and costs were compared between clusters.Results: Among 12,807 patients, 5 clusters were identified: cluster 1: no surgery/low comorbidity/low medication use (n = 4076); cluster 2: no surgery/low comorbidity/high medication use (n = 2201); cluster 3: no surgery/high comorbidity/high medication use (n = 2093); cluster 4: surgery/low comorbidity/moderate medication use (n = 3168); cluster 5: surgery/high comorbidity/high medication use (n = 1269). All-cause HRU was similar across clusters. NP-related HRU was highest in the surgical clusters (clusters 4 and 5). All-cause costs were similar in clusters 1– 3 ($15,833–$17,461) and highest in clusters 4 ($31,083) and 5 ($31,103), dri

Published
2022

17. Real-World Eculizumab Dosing Patterns Among Patients with Paroxysmal Nocturnal Hemoglobinuria in a US Population

Author

Cheng,Wendy Y, Sarda,Sujata P, Mody-Patel,Nikita, Krishnan,Sangeeta, Yenikomshian,Mihran, Kunzweiler,Colin, Vu,Jensen Duy, Cheung,Hoi Ching, Duh,Mei Sheng, Cheng,Wendy Y, Sarda,Sujata P, Mody-Patel,Nikita, Krishnan,Sangeeta, Yenikomshian,Mihran, Kunzweiler,Colin, Vu,Jensen Duy, Cheung,Hoi Ching, and Duh,Mei Sheng

Abstract

Wendy Y Cheng,1 Sujata P Sarda,2 Nikita Mody-Patel,2 Sangeeta Krishnan,2 Mihran Yenikomshian,1 Colin Kunzweiler,1 Jensen Duy Vu,1 Hoi Ching Cheung,1 Mei Sheng Duh1 1Analysis Group, Inc., Boston, MA, USA; 2Apellis Pharmaceuticals, Inc., Waltham, MA, USACorrespondence: Wendy Y Cheng, Analysis Group, Inc., 111 Huntington Ave, 14th Floor, Boston, MA, 02199, USA, Tel +1 617 425 8219, Fax +1 617 425 8000, Email Wendy.Cheng@analysisgroup.comPurpose: Current pharmacologic management of paroxysmal nocturnal hemoglobinuria (PNH) consists of C5 inhibitors, eculizumab and ravulizumab; however, because patients experience incomplete symptom control, off-label doses may be utilized. We conducted a retrospective, longitudinal cohort study of provider-based claims data to assess the real-world eculizumab dosing patterns in PNH patients.Patients and Methods: Patients were ≥ 12 years, received ≥ 2 eculizumab infusions between January 1, 2015 and September 30, 2019, and had ≥ 3 months of continuous clinical activity prior to index. The index date was the first claim for eculizumab. Patients with ≥ 1 diagnosis of another indication for eculizumab were excluded. Treatment patterns including the proportion with high, label-recommended, and low dosages during induction (first 28 days) and maintenance (beginning day 29) phases were described. The proportion and time-to-first dose escalation, defined as an increase in dose or frequency of infusion, were assessed among a subset of patients (ie, escalation analysis cohort).Results: A total of 707 patients were examined. Mean (standard deviation [SD]) starting dose was 862mg (412mg) and was higher than label-recommended 600mg for 64% of the patients. Mean (SD) dose per infusion was 859mg (391mg) during the induction phase; average dose was higher than label-recommended 600mg for 68%. Mean (SD) dose per infusion during the maintenance phase was 1005mg (335mg); average dose was higher than label-recommended 900mg for 43%. Dose escalation

Published
2022

20. Time and Personnel Costs Associated with Adverse Event (AE) Management Among Patients with Chronic Lymphocytic Leukemia (CLL) Treated with Acalabrutinib, Ibrutinib, or Venetoclax

Author

Patel, Hetalkumari, primary, Wahlstrom, Svea K., additional, DerSarkissian, Maral, additional, Kunzweiler, Colin, additional, Castriota, Felicia, additional, Chang, Rose, additional, Cheung, Hoi Ching, additional, Gu, Yuqian, additional, Guo, Helen, additional, Duh, Mei Sheng, additional, and Ryan, Kellie J., additional

Published
2021
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22. Direct and Indirect Costs of Infectious Conjunctivitis in a Commercially Insured Population in the United States

Author

Pepose, Jay S, Sarda, Sujata P, Cheng, Wendy Y, McCormick, Nora, Cheung, Hoi Ching, Bobbili, Priyanka, Joseph, Corey, and Duh, Mei Sheng

Subjects
infectious conjunctivitis, health care resource utilization, vector transmission, costs, charges, Clinical Ophthalmology, health care economics and organizations, Original Research
Abstract

Jay S Pepose,1,2 Sujata P Sarda,3 Wendy Y Cheng,4 Nora McCormick,4 Hoi Ching Cheung,4 Priyanka Bobbili,4 Corey Joseph,3 Mei Sheng Duh4 1Pepose Vision Institute, Chesterfield, MO, USA; 2Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, USA; 3Shire, A Takeda Company, Lexington, MA, USA; 4Analysis Group, Inc., Boston, MA, USACorrespondence: Sujata P SardaTakeda Pharmaceutical Company Limited, 55 Hayden Avenue, Lexington, MA 02421, USATel +1 781 266-3440Email sujata.sarda@takeda.comPurpose: To assess the direct and indirect costs of infectious conjunctivitis and quantify medical costs due to conjunctivitis transmission in families.Methods: In this retrospective claims analysis from the OptumHealth Care Solutions, Inc. database (1998– 2016), beneficiaries with or without at least one diagnosis of infectious conjunctivitis were identified. Direct and indirect costs (in 2016 US$) during the 60 days post conjunctivitis diagnosis (or imputed date for controls) were compared using cost differences in linear regressions. For transmission cost analysis, the total cost of each conjunctivitis episode was the sum of the primary episode (seed patient) and the secondary episode (infected family members) costs. A generalized estimating equation model adjusted for seed patient characteristics was used to assess the impact of number and rate of transmissions on episode cost.Results: Health care resource utilization and direct costs were significantly higher for patients with conjunctivitis (n=1,002,188) versus controls (n=4,877,210): 1.67 all-cause visits per person per month (PPPM) versus 0.79 visits PPPM, respectively; total mean direct cost of $396.04 PPPM versus $289.63 PPPM, respectively. The cost of medically related absenteeism was $105.42 (95% confidence interval [CI], $104.18–$106.75) higher for patients with conjunctivitis than for controls. Episode cost, without transmission due to seed patient, was $669.43 (95% CI, $654.67–$684.85); it increased with each additional infected family member and with increased infection transmission time between family members.Conclusion: Conjunctivitis was associated with a notable economic burden in terms of direct medical costs and medically related absenteeism. Family health care costs increased with transmission time and with each family member infected with conjunctivitis.Keywords: infectious conjunctivitis, costs, charges, health care resource utilization, vector transmission

Published
2020

24. Decreased antibiotic exposure using a procalcitonin protocol for respiratory infections and sepsis in US community hospitals (ProCommunity)

Author

DeSear, Kathryn E., primary, Thompson-Leduc, Philippe, additional, Van Schooneveld, Trevor C., additional, Kirson, Noam, additional, Chritton, Jacqueline J., additional, Ie, Sue, additional, Cheung, Hoi Ching, additional, Ou, Susan, additional, Zimmer, Louise, additional, and Schuetz, Philipp, additional

Published
2021
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31. Direct and Indirect Costs of Infectious Conjunctivitis in a Commercially Insured Population in the United States

Author

Pepose,Jay S, Sarda,Sujata P, Cheng,Wendy Y, McCormick,Nora, Cheung,Hoi Ching, Bobbili,Priyanka, Joseph,Corey, Duh,Mei Sheng, Pepose,Jay S, Sarda,Sujata P, Cheng,Wendy Y, McCormick,Nora, Cheung,Hoi Ching, Bobbili,Priyanka, Joseph,Corey, and Duh,Mei Sheng

Abstract

Jay S Pepose,1,2 Sujata P Sarda,3 Wendy Y Cheng,4 Nora McCormick,4 Hoi Ching Cheung,4 Priyanka Bobbili,4 Corey Joseph,3 Mei Sheng Duh4 1Pepose Vision Institute, Chesterfield, MO, USA; 2Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, USA; 3Shire, A Takeda Company, Lexington, MA, USA; 4Analysis Group, Inc., Boston, MA, USACorrespondence: Sujata P SardaTakeda Pharmaceutical Company Limited, 55 Hayden Avenue, Lexington, MA 02421, USATel +1 781 266-3440Email sujata.sarda@takeda.comPurpose: To assess the direct and indirect costs of infectious conjunctivitis and quantify medical costs due to conjunctivitis transmission in families.Methods: In this retrospective claims analysis from the OptumHealth Care Solutions, Inc. database (1998– 2016), beneficiaries with or without at least one diagnosis of infectious conjunctivitis were identified. Direct and indirect costs (in 2016 US$) during the 60 days post conjunctivitis diagnosis (or imputed date for controls) were compared using cost differences in linear regressions. For transmission cost analysis, the total cost of each conjunctivitis episode was the sum of the primary episode (seed patient) and the secondary episode (infected family members) costs. A generalized estimating equation model adjusted for seed patient characteristics was used to assess the impact of number and rate of transmissions on episode cost.Results: Health care resource utilization and direct costs were significantly higher for patients with conjunctivitis (n=1,002,188) versus controls (n=4,877,210): 1.67 all-cause visits per person per month (PPPM) versus 0.79 visits PPPM, respectively; total mean direct cost of $396.04 PPPM versus $289.63 PPPM, respectively. The cost of medically related absenteeism was $105.42 (95% confidence interval [CI], $104.18–$106.75) higher for patients with conjunctivitis than for controls. Episode cost, without transmission due to seed patient, was

Published
2020

32. Trends of insulin-like growth factor 1, growth hormone, and biochemical control of patients with acromegaly in italy: a longitudinal retrospective chart review study

Author

Ricardo Maamari, Wendy Y. Cheng, Rosario Pivonello, Cheung Hoi Ching, Ludovica F S Grasso, Duh Mei Sheng, Maureen P. Neary, Philippe Thompson-Leduc, Alberto M Pedroncelli, Annamaria Colao, and Cera Marialuisa Di

Subjects
Insulin-like growth factor, medicine.medical_specialty, Endocrinology, business.industry, Chart review, medicine.medical_treatment, Internal medicine, Acromegaly, medicine, Growth hormone, business, medicine.disease
Published
2018
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34. Comorbidities and Survival in Patients With Lipodystrophy: An International Chart Review Study

Author

Akinci, Baris, primary, Oral, Elif A, additional, Neidert, Adam, additional, Rus, Diana, additional, Cheng, Wendy Y, additional, Thompson-Leduc, Philippe, additional, Cheung, Hoi Ching, additional, Bradt, Pamela, additional, Foss de Freitas, Maria Cristina, additional, Montenegro, Renan Magalhães, additional, Fernandes, Virgínia Oliveira, additional, Cochran, Elaine, additional, and Brown, Rebecca J, additional

Published
2019
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37. 3D internal reconstruction by the use of terahertz time domain imaging (THz-TDI): an application on a 15th century stucco relief

Author

L. Leroux, Marc Bormand, Gianluca Gariani, Anne Bouquillon, Fabrice Goubard, D. Brissaud, D. Giovannacci, and M. Cheung Hoi Ching

Subjects
Cultural heritage, Optics, Materials science, Gypsum, business.industry, Terahertz radiation, Acoustics, engineering, Conservation science, Stucco, Time domain, engineering.material, business
Abstract

In the field of Cultural Heritage and conservation science the development of non-invasive tools to retrieve information on artworks and historical artifacts remains one of the most important and increasing demands. In this work a focus was made on the capability of THz imaging to investigate the internal structure of objects made of superposed plaster layers. In particular, a first attempt of investigation was made for gypsum based plaster used for a stucco reliefs. After a feasibility phase on plaster moke up samples, a 15th century painted stucco relief was investigated by means of THz-TDI in the framework of the ESPRIT project, promoted by the Louvre Museum. The objectives were to assess the presence of internal layers made of different plaster mixtures, to locate them and give useful information about the supposed manufacturing techniques. The refractive indexes of different plasters were measured. Due to multiple scattering inside the samples and the impact of the heterogeneity of the material on this refractive index, the interface between plaster/plaster seems difficult to detect.

Published
2017
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38. Temporal and Geographic Variation in the Incidence of Alzheimer's Disease Diagnosis in the US between 2007 and 2014.

Author

Kirson, Noam Y., Meadows, Eric S., Desai, Urvi, Smith, Brian P., Cheung, Hoi Ching, Zuckerman, Peter, and Matthews, Brandy R.

Subjects
ALZHEIMER'S disease, MEDICARE, POPULATION geography, STATISTICAL sampling, CROSS-sectional method, RETROSPECTIVE studies, FEE for service (Medical fees), STATISTICAL models
Abstract

OBJECTIVES: Our aim was to describe the incidence of Alzheimer's disease (AD) in the United States, overall and by geographic region. DESIGN: We conducted retrospective analyses of administrative claims data for a 5% random sample of US Medicare beneficiaries aged 65 years or older. AD incidence, defined as a diagnosis for AD (International Classification of Disease, Ninth Revision, Clinical Modification code 331.0×) in a given year, with no AD diagnosis in the beneficiary's entire medical history, was estimated for each calendar year between 2007 and 2014. Beneficiaries were required to be enrolled in Medicare for the calendar year of evaluation as well as the preceding 12 months. In addition, a cross‐sectional assessment of geographic variation in AD incidence was conducted for 2014. For each population area (specifically, core‐based statistical area, as defined by the US Census Bureau), AD incidence was estimated overall, as well as adjusted for differences in underlying patient demographics and metrics of access to care and quality of care. Changes in AD incidence from 2007 were also estimated. SETTING: US fee‐for‐service Medicare. Participants: US Medicare beneficiaries aged 65 years or older with no history of AD. RESULTS: Overall, the diagnosed incidence of AD decreased over time, from 1.53% in 2007 to 1.09% in 2014; trends were similar for most population areas. In 2014, the rates of AD incidence ranged from 0% to more than 3% across population areas, with the highest observed incidence rates in areas of the Midwest and the South. Statistical models explain little of the geographic variation, although following adjustment, the incidence rates increased the most (in relative terms) in rural areas of western states. CONCLUSION: Our findings are consistent with previously reported estimates of incidence of AD in the United States and its recent declining trend. Additionally, the study highlights the considerable geographic variation in the incidence of AD in the United States and suggests that further research is needed to better understand the determinants of this geographic variation. J Am Geriatr Soc 68:346–353, 2020 [ABSTRACT FROM AUTHOR]

Published
2020
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41. Comorbidities and symptoms among patients with acromegaly in italy: a longitudinal retrospective chart review study

Author

Colao, Annamaria, primary, Grasso, Ludovica, additional, Cera, Marialuisa Di, additional, Cheng, Wendy Y, additional, Thompson-Leduc, Philippe, additional, Cheung, Hoi Ching, additional, Duh, Mei Sheng, additional, Neary, Maureen P, additional, Pedroncelli, Alberto M, additional, Maamari, Ricardo, additional, and Pivonello, Rosario, additional

Published
2018
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42. Association between biochemical control and comorbidities and symptoms among patients with acromegaly in Italy: a longitudinal retrospective chart review study

Author

Colao, Annamaria, primary, Grasso, Ludovica, additional, Cera, Marialuisa Di, additional, Cheng, Wendy Y, additional, Thompson-Leduc, Philippe, additional, Cheung, Hoi Ching, additional, Duh, Mei Sheng, additional, Neary, Maureen P, additional, Pedroncelli, Alberto M, additional, Maamari, Ricardo, additional, and Pivonello, Rosario, additional

Published
2018
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44. Time‐domain imaging system in the terahertz range for immovable cultural heritage materials.

Author

Giovannacci, David, Cheung, Hoi Ching, Walker, Gillian C., Bowen, John W., Martos‐Levif, Dominique, Brissaud, Didier, Cristofol, Lilian, and Mélinge, Yannik

Subjects
*TERAHERTZ technology, *CULTURAL property, *BANDWIDTHS, *LASER spectroscopy, *TIME-domain analysis
Abstract

In the field of cultural heritage science, the use of non‐destructive and contact‐free techniques has increased sharply over the past 10 years. Compared with conventional spectroscopic and imaging techniques such as X‐ray, ultraviolet, infrared, and laser spectroscopy, terahertz time‐domain imaging (THz‐TDI) is an innovative, non‐invasive, and safe technique, which provides good penetration depth (~1 cm) and broad spectral bandwidth (0.1–10 THz). This paper sets out the protocol and methodology for the application of THz‐TDI to immovable cultural heritage, illustrated by a series of case studies. The case studies demonstrate the efficacy of the technique in providing structural and material information for conservators. [ABSTRACT FROM AUTHOR]

Published
2019
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45. From Gadolinium to Generative AI: The Quest for Contrast-Free Cardiac Imaging.

Author

Howard JP and Cheung HC

Subjects
Humans, Gadolinium adverse effects, Predictive Value of Tests, Artificial Intelligence, Cardiac Imaging Techniques adverse effects, Cardiac Imaging Techniques methods, Contrast Media adverse effects, Heart Diseases diagnostic imaging, Magnetic Resonance Imaging adverse effects, Magnetic Resonance Imaging methods
Abstract

Competing Interests: Dr Howard is a shareholder in MyCardium AI Ltd. H.C. Cheung reports no conflicts.

Published
2024
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46. Artificial Intelligence Applications in Space Medicine.

Author

Cheung HC, De Louche C, and Komorowski M

Subjects
Clinical Decision-Making, Vision Disorders, Humans, Mental Health, Aerospace Medicine, Artificial Intelligence
Abstract

INTRODUCTION: During future interplanetary space missions, a number of health conditions may arise, owing to the hostile environment of space and the myriad of stressors experienced by the crew. When managing these conditions, crews will be required to make accurate, timely clinical decisions at a high level of autonomy, as telecommunication delays and increasing distances restrict real-time support from the ground. On Earth, artificial intelligence (AI) has proven successful in healthcare, augmenting expert clinical decision-making or enhancing medical knowledge where it is lacking. Similarly, deploying AI tools in the context of a space mission could improve crew self-reliance and healthcare delivery. METHODS: We conducted a narrative review to discuss existing AI applications that could improve the prevention, recognition, evaluation, and management of the most mission-critical conditions, including psychological and mental health, acute radiation sickness, surgical emergencies, spaceflight-associated neuro-ocular syndrome, infections, and cardiovascular deconditioning. RESULTS: Some examples of the applications we identified include AI chatbots designed to prevent and mitigate psychological and mental health conditions, automated medical imaging analysis, and closed-loop systems for hemodynamic optimization. We also discuss at length gaps in current technologies, as well as the key challenges and limitations of developing and deploying AI for space medicine to inform future research and innovation. Indeed, shifts in patient cohorts, space-induced physiological changes, limited size and breadth of space biomedical datasets, and changes in disease characteristics may render the models invalid when transferred from ground settings into space. Cheung HC, De Louche C, Komorowski M. Artificial intelligence applications in space medicine . Aerosp Med Hum Perform. 2023; 94(8):610-622.

Published
2023
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