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Systolic (SP), diastolic (DP), and mean arterial blood pressures (MAP) and pulse rate (PR) were recorded on treated and untreated conscious cynomolgus monkeys by the oscillometric method (Dinamap 1846SX/P). Each monkey was placed in a restraining tube with the cuff placed on the base on the shaved tail. Measurements were taken on untreated animals once or twice a day for 4 weeks. The mean and standard deviations for SP, DP, MAP, and PR were approximately 121 ± 17, 60 ± 14, and 84 ± 17 mm Hg and 193 ± 18 pulses/min, respectively. One male and one female cynomolgus monkey were treated with isoproterenol, norepinephrine, and nitropmsside. Blood pressure was measured indirectly with the cuff on the tail and directly with an indwelling catheter in the descending thoracic aorta. Although the oscillometric method was not as sensitive as the catheter, the oscillometric method detected a change in the same direction of SP, DP, MAP, and PR compared with the direct method for all drugs administered. The monitor was reliable and sufficiently accurate to conclude that it may be useful in toxicology studies for evaluation of blood pressure parameters in Conscious Cynomolgus monkeys. [ABSTRACT FROM PUBLISHER]

Acute and Subchronic Toxicity Studies with Detirelix, a Luteinizing Hormone-Releasing Hormone Antagonist, in the Rat and Monkey. CHESTER, A. E., FAIRCHILD, D. G., AND DEPASS, L. R. (1991). . 17, 505–518. Acute (single dose), 2-week, and 3-month toxicology studies were conducted with detirelix, a luteinizing hormone-releasing hormone (LHRH) antagonist, in rats and cynomolgus monkeys. Acute studies were conducted by intravenous and subcutaneous injection. Subchronic studies were conducted by daily subcutaneous injection. Clinical signs after a single intravenous dose included lethargy, edema, cyanosis, pallor, and red ears in rats at ≥ 0.3 mg/kg and lethargy and facial flushing in monkeys at ≥0.5 mg/kg, In subchronic studies, detirelix at 0.4 mg/kg/day (rats) and at ≥0.2 mg/kg/day (monkeys) produced atrophy of the reproductive organs, inhibition of ovulation and spermatogenesis, decreased body weight gain in male rats and monkeys, and increased body weight gain in female rats. In the rat, morbidity and/or mortality occurred throughout the treatment phase at a subcutaneous dose of 2.0 mg/kg/day. In both species, the time to recovery of normal reproductive organ morphology and function was directly related to dose. Exogenous testosterone decreased the severity of reproductive and body weight effects in male rats. In conclusion, the acute effects of detirelix were consistent with peripheral vasodilation. Subchronic effects were associated with inhibition of pituitary gonadotropic and gonadal hormone secretion. [ABSTRACT FROM PUBLISHER]