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19 results on '"Chesnut, Megan"'

4. On Stress: Combining Human Factors and Biosignals to Inform the Placement and Design of a Skin-like Stress Sensor

Author

Khan, Yasser, primary, Mauriello, Matthew Louis, additional, Nowruzi, Parsa, additional, Motani, Akshara, additional, Hon, Grace, additional, Vitale, Nicholas, additional, Li, Jinxing, additional, Kim, Jayoung, additional, Foudeh, Amir, additional, Duvio, Dalton, additional, Shols, Erika, additional, Chesnut, Megan, additional, Landay, James A., additional, Liphardt, Jan, additional, Williams, Leanne, additional, Sudheimer, Keith D., additional, Murmann, Boris, additional, Bao, Zhenan, additional, and Paredes, Pablo E, additional

Published
2024
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6. Personalized brain circuit scores identify clinically distinct biotypes in depression and anxiety

Author

Tozzi, Leonardo, Zhang, Xue, Pines, Adam, Olmsted, Alisa M., Zhai, Emily S., Anene, Esther T., Chesnut, Megan, Holt-Gosselin, Bailey, Chang, Sarah, Stetz, Patrick C., Ramirez, Carolina A., Hack, Laura M., Korgaonkar, Mayuresh S., Wintermark, Max, Gotlib, Ian H., Ma, Jun, and Williams, Leanne M.

Abstract

There is an urgent need to derive quantitative measures based on coherent neurobiological dysfunctions or ‘biotypes’ to enable stratification of patients with depression and anxiety. We used task-free and task-evoked data from a standardized functional magnetic resonance imaging protocol conducted across multiple studies in patients with depression and anxiety when treatment free (n= 801) and after randomization to pharmacotherapy or behavioral therapy (n= 250). From these patients, we derived personalized and interpretable scores of brain circuit dysfunction grounded in a theoretical taxonomy. Participants were subdivided into six biotypes defined by distinct profiles of intrinsic task-free functional connectivity within the default mode, salience and frontoparietal attention circuits, and of activation and connectivity within frontal and subcortical regions elicited by emotional and cognitive tasks. The six biotypes showed consistency with our theoretical taxonomy and were distinguished by symptoms, behavioral performance on general and emotional cognitive computerized tests, and response to pharmacotherapy as well as behavioral therapy. Our results provide a new, theory-driven, clinically validated and interpretable quantitative method to parse the biological heterogeneity of depression and anxiety. Thus, they represent a promising approach to advance precision clinical care in psychiatry.

Published
2024
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7. Human IPSC-Derived Model to Study Myelin Disruption

Author

Chesnut, Megan, primary, Paschoud, Hélène, additional, Repond, Cendrine, additional, Smirnova, Lena, additional, Hartung, Thomas, additional, Zurich, Marie-Gabrielle, additional, Hogberg, Helena T., additional, and Pamies, David, additional

Published
2021
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8. Survivors of SARS-CoV-2 Infection Show Neuropsychiatric Sequelae Measured by Surveys, Neurocognitive Testing, and Magnetic Resonance Imaging: Preliminary Results

Author

Hack, Laura M., primary, Brawer, Jacob, additional, Chesnut, Megan, additional, Zhang, Xue, additional, Wintermark, Max, additional, Jiang, Bin, additional, Grant, Philip, additional, Bonilla, Hector, additional, Stetz, Patrick, additional, Yesavage, Jerome A., additional, Subramanian, Aruna, additional, and Williams, Leanne M., additional

Published
2021
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11. Design considerations of a wearable electronic-skin for mental health and wellness: balancing biosignals and human factors

Author

Khan, Yasser, primary, Mauriello, Matthew L., additional, Nowruzi, Parsa, additional, Motani, Akshara, additional, Hon, Grace, additional, Vitale, Nicholas, additional, Li, Jinxing, additional, Kim, Jayoung, additional, Foudeh, Amir, additional, Duvio, Dalton, additional, Shols, Erika, additional, Chesnut, Megan, additional, Landay, James, additional, Liphardt, Jan, additional, Williams, Leanne, additional, Sudheimer, Keith D., additional, Murmann, Boris, additional, Bao, Zhenan, additional, and Paredes, Pablo E., additional

Published
2021
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13. The human connectome project for disordered emotional states: Protocol and rationale for a research domain criteria study of brain connectivity in young adult anxiety and depression

Author

Tozzi, Leonardo, primary, Staveland, Brooke, additional, Holt-Gosselin, Bailey, additional, Chesnut, Megan, additional, Chang, Sarah E., additional, Choi, David, additional, Shiner, Melissa, additional, Wu, Hua, additional, Lerma-Usabiaga, Garikoitz, additional, Sporns, Olaf, additional, Barch, Deanna M., additional, Gotlib, Ian H., additional, Hastie, Trevor J., additional, Kerr, Adam B., additional, Poldrack, Russell A., additional, Wandell, Brian A., additional, Wintermark, Max, additional, and Williams, Leanne M., additional

Published
2020
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14. The human connectome project for disordered emotional states: Protocol and rationale for a research domain criteria study of brain connectivity in young adult anxiety and depression

Author

Tozzi, Leonardo, Staveland, Brooke, Holt-Gosselin, Bailey, Chesnut, Megan, Chang, Sarah E., Choi, David, Shiner, Melissa, Wu, Hua, Lerma-Usabiaga, Garikoitz, Sporns, Olaf, Barch, Deanna M., Gotlib, Ian H., Hastie, Trevor J., Kerr, Adam B., Poldrack, Russell A., Wandell, Brian A., Wintermark, Max, Williams, Leanne M., Tozzi, Leonardo, Staveland, Brooke, Holt-Gosselin, Bailey, Chesnut, Megan, Chang, Sarah E., Choi, David, Shiner, Melissa, Wu, Hua, Lerma-Usabiaga, Garikoitz, Sporns, Olaf, Barch, Deanna M., Gotlib, Ian H., Hastie, Trevor J., Kerr, Adam B., Poldrack, Russell A., Wandell, Brian A., Wintermark, Max, and Williams, Leanne M.

Abstract

Available online 5 March 2020., Through the Human Connectome Project (HCP) our understanding of the functional connectome of the healthy brain has been dramatically accelerated. Given the pressing public health need, we must increase our understanding of how connectome dysfunctions give rise to disordered mental states. Mental disorders arising from high levels of negative emotion or from the loss of positive emotional experience affect over 400 million people globally. Such states of disordered emotion cut across multiple diagnostic categories of mood and anxiety disorders and are compounded by accompanying disruptions in cognitive function. Not surprisingly, these forms of psychopathology are the leading cause of disability worldwide. The Research Domain Criteria (RDoC) initiative spearheaded by NIMH offers a framework for characterizing the relations among connectome dysfunctions, anchored in neural circuits and phenotypic profiles of behavior and self-reported symptoms. Here, we report on our Connectomes Related to Human Disease protocol for integrating an RDoC framework with HCP protocols to characterize connectome dysfunctions in disordered emotional states, and present quality control data from a representative sample of participants. We focus on three RDoC domains and constructs most relevant to depression and anxiety: 1) loss and acute threat within the Negative Valence System (NVS) domain; 2) reward valuation and responsiveness within the Positive Valence System (PVS) domain; and 3) working memory and cognitive control within the Cognitive System (CS) domain. For 29 healthy controls, we present preliminary imaging data: functional magnetic resonance imaging collected in the resting state and in tasks matching our constructs of interest (“Emotion”, “Gambling” and “Continuous Performance” tasks), as well as diffusion-weighted imaging. All functional scans demonstrated good signal-to-noise ratio. Established neural networks were robustly identified in the resting state condition by independ

Published
2020

15. Antidepressant Paroxetine Exerts Developmental Neurotoxicity in an iPSC-Derived 3D Human Brain Model

Author

Zhong, Xiali, primary, Harris, Georgina, additional, Smirnova, Lena, additional, Zufferey, Valentin, additional, Sá, Rita de Cássia da Silveira e, additional, Baldino Russo, Fabiele, additional, Baleeiro Beltrao Braga, Patricia Cristina, additional, Chesnut, Megan, additional, Zurich, Marie-Gabrielle, additional, Hogberg, Helena T., additional, Hartung, Thomas, additional, and Pamies, David, additional

Published
2020
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