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236 results on '"Cheong, Kai Xiong"'

2. Comparing generative and retrieval-based chatbots in answering patient questions regarding age-related macular degeneration and diabetic retinopathy

Author

Cheong, Kai Xiong, primary, Zhang, Chenxi, additional, Tan, Tien-En, additional, Fenner, Beau J, additional, Wong, Wendy Meihua, additional, Teo, Kelvin YC, additional, Wang, Ya Xing, additional, Sivaprasad, Sobha, additional, Keane, Pearse A, additional, Lee, Cecilia Sungmin, additional, Lee, Aaron Y, additional, Cheung, Chui Ming Gemmy, additional, Wong, Tien Yin, additional, Cheong, Yun-Gyung, additional, Song, Su Jeong, additional, and Tham, Yih Chung, additional

Published
2024
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16. PATTERN AND CHARACTERISTICS OF DRUSEN SUBTYPES IN CHINESE AND INDIAN POPULATIONS IN SINGAPORE

Author

Takahashi, Kengo, primary, Song, Youngseok, additional, Cheong, Kai Xiong, additional, Fenner, Beau J., additional, Teo, Kelvin Yi Chong, additional, Chee, Miao Li, additional, Li, Hengtong, additional, Tham, Yih-Chung, additional, Cheung, Chui Ming Gemmy, additional, Cheng, Ching-Yu, additional, Wong, Tien Yin, additional, Yanagi, Yasuo, additional, and Tan, Anna C. S., additional

Published
2023
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17. Pneumatic displacement of submacular haemorrhage secondary to neovascular age-related macular degeneration and polypoidal choroidal vasculopathy

Author

Sim, Shaun Sebastian, Cheong, Kai Xiong, Chan, Hiok Hong, Choo, Jessica Qian Hui, Tsai, Andrew S. H., Lee, Shu Yen, Yeo, Ian Yew San, Cheung, Chui Ming Gemmy, and Teo, Kelvin Yi Chong

Abstract

Background: To compare the visual and anatomical outcomes of pneumatic displacement (PD) combined with anti-vascular endothelial growth factor (VEGF) therapy versus anti-VEGF monotherapy in treatment-naive eyes with submacular haemorrhage (SMH) secondary to neovascular age-related macular degeneration and polypoidal choroidal vasculopathy. Methods: In a retrospective comparative interventional study of 57 eyes, the changes in logMAR visual acuity (VA), and SMH height and area at baseline at months 1, 3 and 12 were compared between the PD and non-PD groups. Results: There was no significant difference in mean VA in the PD versus non-PD group at month 12 (1.1 versus 0.7, p= 0.09). At baseline, the PD group, compared to the non-PD group, had significantly larger SMH area (35.9 versus 26.9 mm2, p= 0.04) and SMH height at the fovea (733.7 versus 503.6 µm, p< 0.01). The greatest reduction in SMH height and area occurred between baseline and month 1 in the PD group, which was faster than between month 1 and month 3 in the non-PD group, with similar findings in the matched pair analysis matched for SMH height and area. In the multivariable analysis, only baseline VA was associated with VA outcomes (month 1: β= −0.46, 95% [confidence interval] CI = −0.78 to −0.14, p= 0.006; month 3: β= −0.52, 95% CI = −0.86 to −0.18, p= 0.004; and month 12: β= −0.78, 95% CI = −1.16 to −0.39, p< 0.001). Conclusions: The visual outcome of SMH at month 12 in nAMD and PCV is poor regardless of whether PD is performed in addition to anti-VEGF therapy, although a more rapid resolution of SMH can be expected.

Published
2024
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26. Patterns and Determinants of Choroidal Thickness in a Multiethnic Asian Population: The Singapore Epidemiology of Eye Diseases Study

Author

Song, Youngseok, primary, Tham, Yih-Chung, additional, Chong, Crystal, additional, Ong, Ricardo, additional, Fenner, Beau J., additional, Cheong, Kai Xiong, additional, Takahashi, Kengo, additional, Jordan-Yu, Janice Marie, additional, Teo, Kelvin Yi Chong, additional, Tan, Anna C.S., additional, Cheng, Ching-Yu, additional, Wong, Tien Yin, additional, Chakravarthy, Usha, additional, Yanagi, Yasuo, additional, and Cheung, Gemmy Chui Ming, additional

Published
2021
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46. Association of SNTB1 with High Myopia.

Author

Cheong, Kai Xiong, Yong, Rita Yu Yin, Tan, Mellisa Mei Hui, Tey, Frederick Lian Kheng, and Ang, Bryan Chin Hou

Subjects
*MYOPIA, *CHINESE people, *SINGLE nucleotide polymorphisms
Abstract

To investigate the associations of Single Nucleotide Polymorphisms (SNPs) in the SNTB1 gene with high myopia in a Han Chinese population. Based on previous studies, four SNPs from the SNTB1 gene were chosen for genotyping. This is a case-control genetic association study comprising 193 high myopia participants and 135 normal emmetropic controls from a Han Chinese population. Allelic frequencies of the SNPs and haplotypes were compared to assess the associations of the SNPs with high myopia and axial length (AL). The SNPs rs7839488 (effect allele: A; OR = 0.685), rs4395927 (effect allele: T; OR = 0.692), and rs6469937 (effect allele: A; OR = 0.683) displayed significant associations with high myopia initially (P =.044, 0.049, and 0.035, respectively), but did not withstand permutation testing (all Ppermutation>0.05). rs6469937 displayed associations with high myopia in the dominant model (AG+AA: OR = 0.609) against GG (reference). rs6469937 was also associated with AL in the dominant model (AG+AA: Beta = −0.58) against GG (reference). The haplotype analysis demonstrated ATGA as the protective haplotype against high myopia, which remained statistically significant in permutation testing (Ppermutation = 0.045). Our findings are suggestive that SNTB1 is associated with high myopia in a Han Chinese population. [ABSTRACT FROM AUTHOR]

Published
2021
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