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3. Validation of the 2022 European LeukemiaNet risk stratification for acute myeloid leukemia

Author

Song, Ga-Young, Kim, Hyeon-Jong, Kim, TaeHyung, Ahn, Seo-Yeon, Jung, Sung-Hoon, Kim, Mihee, Yang, Deok-Hwan, Lee, Je-Jung, Kim, Mi Yeon, Cheong, June-Won, Jung, Chul Won, Jang, Jun Ho, Kim, Hee- Je, Moon, Joon Ho, Sohn, Sang Kyun, Won, Jong-Ho, Park, Seong Kyu, Kim, Sung-Hyun, Choi, Chang Kyun, Kim, Hyeoung-Joon, Ahn, Jae-Sook, and Kim, Dennis Dong Hwan

Published
2024
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6. Momelotinib versus danazol in symptomatic patients with anaemia and myelofibrosis (MOMENTUM): results from an international, double-blind, randomised, controlled, phase 3 study

Author

Abulafia, Adi Shacham, Al-Ali, Haifa Kathrin, Andreasson, Bjorn, Angona, Anna, Ayala, Rosa, Bang, Soo-Mee, Bank, Bruce, Barraco, Fiorenza, Beggiato, Eloise, Benghiat, Fleur Samantha, Bonifacio, MassimiliaNo, Bories, Claire, Borsaru, Gabriela, Brabrand, Mette, Braester, Andrei, Broliden, Andes, Buxhofer-Ausch, Veronika, Cambier, Nathalie, Caramella, Marianna, Carpentier, Benjamin, Cascavilla, Nicola, Castellano, Maria Giraldo, Chang, Hung, Chen, Chih-Cheng, Cheong, June-Won, Choi, Yunsuk, Choi, Philip, Corsetti, Maria Teresa, Cuadrado, Isabel Montero, Cunningham, Julia, Damaj, Gandhi Laurent, De Stefano, Valerio, Delage, Robert, Delgado, Regina Garcĺa, Diaz, Jose Miguel Torregrosa, Dombi, Péter, Dubruille, Viviane, Egyed, Miklós, El Fassi, Daniel, Elinder-Camburn, Anna, Elli, Elena Maria, Ellis, Martin, Fava, Carmen, Fazal, Salman, Fleischman, Angela, Foltz, Lynda, Fox, Laura, Gabrail, Nashat, Garcĺa-Gutiérrez, Jose Valentĺn, Gerds, Aaron, Girault, Stephane, Gisslinger, Heinz, Gluvacov, Alexandru, Goh, Yeow Tee, Göthert, Joachim, Granacher, Nikki, Grosicki, Sebastian, Gupta, Vikas, Hadjiev (Hadzhiev), Evgeni (Evgueniy), Hafraoui, Kaoutar, Hamed, Aryan, Harrison, Claire, Hasselbalch, Hans, Hauser, Hanns, Heaney, Mark, Hebart, Holger, Hernandez Rivas, Jesus Maria, Higuero Saavedra, Victor, Hillis, Christopher, Hou, Hsin-An, How, Jonathan, Huang, Daniel, Hus, Marek, Illés, Arpad, Isidori, Alessandro, Iurlo, Alessandra, Ivanov, Vadim, Johansson, Peter, Jung, Chul Won, Kiladjian, Jean-Jacques, Kirgner, Ilya, Koren-Michowitz, Maya, Koschmieder, Steffen, Kosztolanyi, Szabolcs Ors, Kreiniz, Natalia, Kuykendall, Andrew, Lambert, Jonathan, Laribi, Kamel, Lascaux, Axelle, Lavie, Noa, Lavie, David, Lazaroiu, Mihaela, Leahy, Michael, Lech-Maranda, Ewa, Lee, Sung-Eun, Lee, Won Sik, Legrand, Ollivier, Lemoli, Roberto, Liang, James, Lim, Sung-Nam, Loschi, Michael, Lucchesi, Alessandro, Macarie, Ioan, Marolleau, Jean-Pierre, Martelli, Maurizio, Mayer, Jiri, McCloskey, James, McDermott, Christopher, McLornan, Donal, McMahon, Brandon, Mehta, Priyanka, Mesa, Ruben, Mikala, Gábor, Milojkovic, Dragana, Mineur, Philippe, Mishchenko, Elena, Moon, Joon Ho, Nagy, Zsolt, Narayanan, Srinivasan, O'Connell, Casey, Ocroteala, Luminita, Oh, Stephen, Ojeda-Uribe, Mario, Ong, Kiat Hoe, Otegbeye, Folashade, Palmer, Jeanne, Pane, Fabrizio, Passamonti, Francesco, Patriarca, Andrea, Perkins, Andrew, Pietrantuono, Giuseppe, Plander, Mark, Platzbecker, Uwe, Prasad, Ritam, Prejzner, Witold, Rachow, Tobias, Radinoff, Atanas, Rejtő, László, Rinaldi, Ciro, Robak, Tadeusz, Rodriguez, Maria Angeles Fernandez, Ronson, Aaron, Ross, David, Sacha, Tomasz, Sadjadian, Parvis, Salar, Antonio, Santillana, Guillermo Sanz, Scheid, Christof, Schmidt, Aline, Severinsen, Marianne Tang, Stoeva, Vera, Szwedyk, Paweł, Tiribelli, Mario, Trautmann-Grill, Karolin, Trottier, Amy, Tzvetkov, Nikolay, van Droogenbroeck, Janusz, Vannucchi, Alessandro, Verstovsek, Srdan, Vianelli, Nicola, von Bubnoff, Nikolas, Wolf, Dominik, Woszczyk, Dariusz, Woźny, Tomasz, Wróbel, Tomasz, Xicoy, Blanca, Yeh, Su-Peng, Yoon, Sung-Soo, Gerds, Aaron T, Vannucchi, Alessandro M, Kuykendall, Andrew T, Lazaroiu, Mihaela C, Egyed, Miklos, Fox, Maria Laura, Harrison, Claire N, Klencke, Barbara J, Ro, Sunhee, Donahue, Rafe, and Kawashima, Jun

Published
2023
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7. Pevonedistat in East Asian patients with acute myeloid leukemia or myelodysplastic syndromes: a phase 1/1b study to evaluate safety, pharmacokinetics and activity as a single agent and in combination with azacitidine

Author

Handa, Hiroshi, Cheong, June-Won, Onishi, Yasushi, Iida, Hiroatsu, Kobayashi, Yukio, Kim, Hyeoung-Joon, Chiou, Tzeon-Jye, Izutsu, Koji, Tsukurov, Olga, Zhou, Xiaofei, Faessel, Helene, Yuan, Ying, Sedarati, Farhad, Faller, Douglas V., Kimura, Akiko, and Wu, Shang-Ju

Published
2022
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9. The association of genetic alterations with response rate in newly diagnosed chronic myeloid leukemia patients

Author

Park, Hyunkyung, Kang, Sungbong, Kim, Inho, Kim, Sangsoo, Kim, Hyeong-Joon, Shin, Dong-Yeop, Kim, Dae-Young, Lee, Kyoo-Hyung, Ahn, Jae-Sook, Sohn, Sang-Kyun, Lee, Jeong-Ok, Cheong, June-Won, Kim, Kyoung Ha, Kim, Hoon-Gu, Kim, Hawk, Lee, Yoo Jin, Nam, Seung-Hyun, Do, Young Rok, Park, Sang-Gon, Park, Seong Kyu, Song, Hun Ho, Jung, Chul Won, and Park, Seonyang

Published
2022
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10. Ultra-deep sequencing mutation analysis of the BCR/ABL1 kinase domain in newly diagnosed chronic myeloid leukemia patients

Author

Park, Hyunkyung, Kim, Inho, Kim, Hyeong-Joon, Shin, Dong-Yeop, Lee, Sung-Yeoun, Kwon, Oh-Hyung, Kim, Dae-Young, Lee, Kyoo-Hyung, Ahn, Jae-Sook, Park, Jinny, Sohn, Sang-Kyun, Lee, Jeong-Ok, Cheong, June-Won, Kim, Kyoung Ha, Kim, Hoon-Gu, Kim, Hawk, Lee, Yoo Jin, Nam, Seung-Hyun, Do, Young Rok, Park, Sang-Gon, Park, Seong Kyu, Bae, Sung Hwa, Song, Hun Ho, Oh, Doyeun, Jung, Chul Won, and Park, Seonyang

Published
2021
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13. Identification of MYC as an antinecroptotic protein that stifles RIPK1–RIPK3 complex formation

Author

Seong, Daehyeon, Jeong, Manhyung, Seo, Jinho, Lee, Ji-Yoon, Hwang, Chi Hyun, Shin, Ho-Chul, Shin, Jeong Yoon, Nam, Young Woo, Jo, Jeong Yeon, Lee, Haeseung, Kim, Hye-Jung, Kim, Hwa-Ryeon, Oh, Ji Hoon, Ha, Sang-Jun, Kim, Seung Jun, Roe, Jae-Seok, Kim, Wankyu, Cheong, June-Won, Bae, Kwang-Hee, Lee, Sang Chul, Oberst, Andrew, Vandenabeele, Peter, Shin, Dong Hoon, Lee, Eun-Woo, and Song, Jaewhan

Published
2020

17. Gilteritinib as Post-Transplant Maintenance for Acute Myeloid Leukemia With Internal Tandem Duplication Mutation of FLT3

Author

Levis, M, Hamadani, M, Logan, B, Jones, R, Singh, A, Litzow, M, Wingard, J, Papadopoulos, E, Perl, A, Soiffer, R, Ustun, C, Ueda Oshima, M, Uy, G, Waller, E, Vasu, S, Solh, M, Mishra, A, Muffly, L, Kim, H, Mikesch, J, Najima, Y, Onozawa, M, Thomson, K, Nagler, A, Wei, A, Marcucci, G, Geller, N, Hasabou, N, Delgado, D, Rosales, M, Hill, J, Gill, S, Nuthethi, R, King, D, Wittsack, H, Mendizabal, A, Devine, S, Horowitz, M, Chen, Y, Agura, E, Altman, J, Anagnostopoulos, A, Anand, S, Artz, A, Aulitzky, W, Balderman, S, Ballen, K, Becker, M, Beguin, Y, Berkahn, L, Berneman, Z, Bhatt, V, Bilmon, I, Bonifazi, F, Briggs, A, Bruno, B, Brunstein, C, Byrne, M, Byrne, J, Cabrero, M, Cairoli, R, Carrum, G, Cerny, J, Cheong, J, Ciceri, F, Colorado, M, Cook, R, Couriel, D, Craddock, C, Damon, L, Deol, A, Desbrosses, Y, Di Grazia, C, Di Stasi, A, Dias, A, Dorritie, K, Essell, J, Eto, T, Farag, S, Forcade, E, Frankfurt, O, Fujiwara, S, Fukuda, T, Fukushima, K, Furst, S, Goto, T, Hall, A, Hatta, S, Hicheri, Y, Horwitz, M, Hou, H, How, J, Howard, D, Hsu, W, Huynh, A, Irvine, D, Ishikawa, T, Jamieson, K, Jedrzejczak, W, Jethava, Y, Jimenez, A, Jung, C, Kanda, J, Karakasis, D, Kato, J, Kekre, N, Khera, N, Klein, A, Kobbe, G, Kornblit, B, Kota, V, Lachance, S, Leber, B, Lee, C, Lee, J, Lin, T, Liu, T, Martelli, M, Martinez, C, Matsuoka, K, Mccarty, J, Mendez, L, Michelis, F, Mineishi, S, Mohty, M, Moors, I, Motyckova, G, Mueller, L, Nakamae, H, Nakano, N, Nathan, S, Nicholson, E, Norkin, M, Ogawa, Y, Olesen, G, Oluwole, O, Pantin, J, Paulson, K, Pemberton, L, Perera, T, Piatkowska-Jakubas, B, Poire, X, Protheroe, R, Rambaldi, A, Ritchie, D, Ross, K, Rubio, M, Santarone, S, Sanz Caballer, J, Sawa, M, Schaar, D, Scheid, C, Schriber, J, Seropian, S, Shah, N, Shore, T, Gil, J, Sobecks, R, Socie, G, Sprague, K, Spyridonidis, A, Stelljes, M, Stiff, P, Stuart, R, Tanaka, M, Tandra, A, Tholouli, E, Thomas, X, Tiribelli, M, Tomlinson, B, Tsirigotis, P, Tzachanis, D, Uchida, N, Ueda, M, Valcarcel Ferreiras, D, Wagner, E, Watson, A, Weisdorf, D, Wolschke, C, Wrobel, T, Yakoub-Agha, I, Yamauchi, T, Yared, J, Yeh, S, Yoon, S, Yoshihara, S, Null, N, Levis, Mark J., Hamadani, Mehdi, Logan, Brent, Jones, Richard J., Singh, Anurag K., Litzow, Mark, Wingard, John R., Papadopoulos, Esperanza B., Perl, Alexander E., Soiffer, Robert J., Ustun, Celalettin, Ueda Oshima, Masumi, Uy, Geoffrey L., Waller, Edmund K., Vasu, Sumithra, Solh, Melhem, Mishra, Asmita, Muffly, Lori, Kim, Hee-Je, Mikesch, Jan-Henrik, Najima, Yuho, Onozawa, Masahiro, Thomson, Kirsty, Nagler, Arnon, Wei, Andrew H., Marcucci, Guido, Geller, Nancy L., Hasabou, Nahla, Delgado, David, Rosales, Matt, Hill, Jason, Gill, Stanley C., Nuthethi, Rishita, King, Denise, Wittsack, Heather, Mendizabal, Adam, Devine, Steven M., Horowitz, Mary M., Chen, Yi-Bin, Agura, Ed, Altman, Jessica, Anagnostopoulos, Achiles, Anand, Sarah, Artz, Andrew, Aulitzky, Walter, Balderman, Sophia, Ballen, Karen, Becker, Michael, Beguin, Yves, Berkahn, Leanne, Berneman, Zwi, Bhatt, Vijaya, Bilmon, Ian, Bonifazi, Francesca, Briggs, Adrienne, Bruno, Benedetto, Brunstein, Claudio, Byrne, Michael, Byrne, Jenny, Cabrero, Monica, Cairoli, Roberto, Carrum, George, Cerny, Jan, Cheong, June-Won, Ciceri, Fabio, Colorado, Mercedes, Cook, Rachel, Couriel, Daniel, Craddock, Charles, Damon, Lloyd, Deol, Abhinav, Desbrosses, Yohan, Devine, Steve, Di Grazia, Carmela, Di Stasi, Antonio, Dias, Ajoy, Dorritie, Kathy, Essell, James, Eto, Tetsuya, Farag, Sherif, Forcade, Edouard, Frankfurt, Olga, Fujiwara, Shinichiro, Fukuda, Takahiro, Fukushima, Kentaro, Furst, Sabine, Goto, Tatsunori, Hall, Aric, Hatta, Shunsuke, Hicheri, Yosr, Horwitz, Mitchell, Hou, Hsin-An, How, Jonathan, Howard, Dianna, Hsu, Wei-Hsun (Blake), Huynh, Anne, Irvine, David, Ishikawa, Takayuki, Jamieson, Katarzyna, Jedrzejczak, Wieslaw, Jethava, Yogesh, Jimenez, Antonio, Jung, Chul Won, Kanda, Junya, Karakasis, Dimitrios, Kato, Jun, Kekre, Natasha, Khera, Nandita, Klein, Andreas, Kobbe, Guido, Kornblit, Brian, Kota, Vamsi, Lachance, Silvy, Leber, Brian, Lee, Catherine, Lee, Je Hwan, Lin, Tung-Liang, Liu, Ta-Chih, Martelli, Maurizio, Martinez, Carmen, Matsuoka, Kenichi, McCarty, John, Mendez, Lourdes, Michelis, Fotios, Mineishi, Shin, Mohty, Mohamad, Moors, Ine, Motyckova, Gabriela, Mueller, Lutz, Nakamae, Hirohisa, Nakano, Nobuaki, Nathan, Sunita, Nicholson, Emma, Norkin, Maxim, Ogawa, Yoshiaki, Olesen, Gitte, Oluwole, Olalekan, Pantin, Jeremy, Paulson, Kristjan, Pemberton, Lucy, Perera, Travis, Piatkowska-Jakubas, Beata, Poire, Xavier, Protheroe, Rachel, Rambaldi, Alessandro, Ritchie, David, Ross, Kelly, Rubio, Marie-Therese, Santarone, Stella, Sanz Caballer, Jaime, Sawa, Masashi, Schaar, Dale, Scheid, Christoph, Schriber, Jeffrey, Seropian, Stuart, Shah, Nilay, Shah, Nirav, Shore, Tsiporah, Gil, Jorge Sierra, Singh, Anurag, Sobecks, Ronald, Socie, Gerard, Soiffer, Robert, Sprague, Kellie, Spyridonidis, Alexandros, Stelljes, Matthias, Stiff, Patrick, Stuart, Robert, Tanaka, Masatsugu, Tandra, Anand, Tholouli, Eleni, Thomas, Xavier, Tiribelli, Mario, Tomlinson, Benjamin, Tsirigotis, Panagiotis, Tzachanis, Dimitrios, Uchida, Naoyuki, Ueda, Masumi, Valcarcel Ferreiras, David, Wagner, Eva, Watson, Anne-Marie, Weisdorf, Daniel, Wolschke, Christine, Wrobel, Tomasz, Yakoub-Agha, Ibrahim, Yamauchi, Takuji, Yared, Jean, Yeh, Su-Peng, Yoon, Sung-Soo, Yoshihara, Satoshi, null, null, Levis, M, Hamadani, M, Logan, B, Jones, R, Singh, A, Litzow, M, Wingard, J, Papadopoulos, E, Perl, A, Soiffer, R, Ustun, C, Ueda Oshima, M, Uy, G, Waller, E, Vasu, S, Solh, M, Mishra, A, Muffly, L, Kim, H, Mikesch, J, Najima, Y, Onozawa, M, Thomson, K, Nagler, A, Wei, A, Marcucci, G, Geller, N, Hasabou, N, Delgado, D, Rosales, M, Hill, J, Gill, S, Nuthethi, R, King, D, Wittsack, H, Mendizabal, A, Devine, S, Horowitz, M, Chen, Y, Agura, E, Altman, J, Anagnostopoulos, A, Anand, S, Artz, A, Aulitzky, W, Balderman, S, Ballen, K, Becker, M, Beguin, Y, Berkahn, L, Berneman, Z, Bhatt, V, Bilmon, I, Bonifazi, F, Briggs, A, Bruno, B, Brunstein, C, Byrne, M, Byrne, J, Cabrero, M, Cairoli, R, Carrum, G, Cerny, J, Cheong, J, Ciceri, F, Colorado, M, Cook, R, Couriel, D, Craddock, C, Damon, L, Deol, A, Desbrosses, Y, Di Grazia, C, Di Stasi, A, Dias, A, Dorritie, K, Essell, J, Eto, T, Farag, S, Forcade, E, Frankfurt, O, Fujiwara, S, Fukuda, T, Fukushima, K, Furst, S, Goto, T, Hall, A, Hatta, S, Hicheri, Y, Horwitz, M, Hou, H, How, J, Howard, D, Hsu, W, Huynh, A, Irvine, D, Ishikawa, T, Jamieson, K, Jedrzejczak, W, Jethava, Y, Jimenez, A, Jung, C, Kanda, J, Karakasis, D, Kato, J, Kekre, N, Khera, N, Klein, A, Kobbe, G, Kornblit, B, Kota, V, Lachance, S, Leber, B, Lee, C, Lee, J, Lin, T, Liu, T, Martelli, M, Martinez, C, Matsuoka, K, Mccarty, J, Mendez, L, Michelis, F, Mineishi, S, Mohty, M, Moors, I, Motyckova, G, Mueller, L, Nakamae, H, Nakano, N, Nathan, S, Nicholson, E, Norkin, M, Ogawa, Y, Olesen, G, Oluwole, O, Pantin, J, Paulson, K, Pemberton, L, Perera, T, Piatkowska-Jakubas, B, Poire, X, Protheroe, R, Rambaldi, A, Ritchie, D, Ross, K, Rubio, M, Santarone, S, Sanz Caballer, J, Sawa, M, Schaar, D, Scheid, C, Schriber, J, Seropian, S, Shah, N, Shore, T, Gil, J, Sobecks, R, Socie, G, Sprague, K, Spyridonidis, A, Stelljes, M, Stiff, P, Stuart, R, Tanaka, M, Tandra, A, Tholouli, E, Thomas, X, Tiribelli, M, Tomlinson, B, Tsirigotis, P, Tzachanis, D, Uchida, N, Ueda, M, Valcarcel Ferreiras, D, Wagner, E, Watson, A, Weisdorf, D, Wolschke, C, Wrobel, T, Yakoub-Agha, I, Yamauchi, T, Yared, J, Yeh, S, Yoon, S, Yoshihara, S, Null, N, Levis, Mark J., Hamadani, Mehdi, Logan, Brent, Jones, Richard J., Singh, Anurag K., Litzow, Mark, Wingard, John R., Papadopoulos, Esperanza B., Perl, Alexander E., Soiffer, Robert J., Ustun, Celalettin, Ueda Oshima, Masumi, Uy, Geoffrey L., Waller, Edmund K., Vasu, Sumithra, Solh, Melhem, Mishra, Asmita, Muffly, Lori, Kim, Hee-Je, Mikesch, Jan-Henrik, Najima, Yuho, Onozawa, Masahiro, Thomson, Kirsty, Nagler, Arnon, Wei, Andrew H., Marcucci, Guido, Geller, Nancy L., Hasabou, Nahla, Delgado, David, Rosales, Matt, Hill, Jason, Gill, Stanley C., Nuthethi, Rishita, King, Denise, Wittsack, Heather, Mendizabal, Adam, Devine, Steven M., Horowitz, Mary M., Chen, Yi-Bin, Agura, Ed, Altman, Jessica, Anagnostopoulos, Achiles, Anand, Sarah, Artz, Andrew, Aulitzky, Walter, Balderman, Sophia, Ballen, Karen, Becker, Michael, Beguin, Yves, Berkahn, Leanne, Berneman, Zwi, Bhatt, Vijaya, Bilmon, Ian, Bonifazi, Francesca, Briggs, Adrienne, Bruno, Benedetto, Brunstein, Claudio, Byrne, Michael, Byrne, Jenny, Cabrero, Monica, Cairoli, Roberto, Carrum, George, Cerny, Jan, Cheong, June-Won, Ciceri, Fabio, Colorado, Mercedes, Cook, Rachel, Couriel, Daniel, Craddock, Charles, Damon, Lloyd, Deol, Abhinav, Desbrosses, Yohan, Devine, Steve, Di Grazia, Carmela, Di Stasi, Antonio, Dias, Ajoy, Dorritie, Kathy, Essell, James, Eto, Tetsuya, Farag, Sherif, Forcade, Edouard, Frankfurt, Olga, Fujiwara, Shinichiro, Fukuda, Takahiro, Fukushima, Kentaro, Furst, Sabine, Goto, Tatsunori, Hall, Aric, Hatta, Shunsuke, Hicheri, Yosr, Horwitz, Mitchell, Hou, Hsin-An, How, Jonathan, Howard, Dianna, Hsu, Wei-Hsun (Blake), Huynh, Anne, Irvine, David, Ishikawa, Takayuki, Jamieson, Katarzyna, Jedrzejczak, Wieslaw, Jethava, Yogesh, Jimenez, Antonio, Jung, Chul Won, Kanda, Junya, Karakasis, Dimitrios, Kato, Jun, Kekre, Natasha, Khera, Nandita, Klein, Andreas, Kobbe, Guido, Kornblit, Brian, Kota, Vamsi, Lachance, Silvy, Leber, Brian, Lee, Catherine, Lee, Je Hwan, Lin, Tung-Liang, Liu, Ta-Chih, Martelli, Maurizio, Martinez, Carmen, Matsuoka, Kenichi, McCarty, John, Mendez, Lourdes, Michelis, Fotios, Mineishi, Shin, Mohty, Mohamad, Moors, Ine, Motyckova, Gabriela, Mueller, Lutz, Nakamae, Hirohisa, Nakano, Nobuaki, Nathan, Sunita, Nicholson, Emma, Norkin, Maxim, Ogawa, Yoshiaki, Olesen, Gitte, Oluwole, Olalekan, Pantin, Jeremy, Paulson, Kristjan, Pemberton, Lucy, Perera, Travis, Piatkowska-Jakubas, Beata, Poire, Xavier, Protheroe, Rachel, Rambaldi, Alessandro, Ritchie, David, Ross, Kelly, Rubio, Marie-Therese, Santarone, Stella, Sanz Caballer, Jaime, Sawa, Masashi, Schaar, Dale, Scheid, Christoph, Schriber, Jeffrey, Seropian, Stuart, Shah, Nilay, Shah, Nirav, Shore, Tsiporah, Gil, Jorge Sierra, Singh, Anurag, Sobecks, Ronald, Socie, Gerard, Soiffer, Robert, Sprague, Kellie, Spyridonidis, Alexandros, Stelljes, Matthias, Stiff, Patrick, Stuart, Robert, Tanaka, Masatsugu, Tandra, Anand, Tholouli, Eleni, Thomas, Xavier, Tiribelli, Mario, Tomlinson, Benjamin, Tsirigotis, Panagiotis, Tzachanis, Dimitrios, Uchida, Naoyuki, Ueda, Masumi, Valcarcel Ferreiras, David, Wagner, Eva, Watson, Anne-Marie, Weisdorf, Daniel, Wolschke, Christine, Wrobel, Tomasz, Yakoub-Agha, Ibrahim, Yamauchi, Takuji, Yared, Jean, Yeh, Su-Peng, Yoon, Sung-Soo, Yoshihara, Satoshi, and null, null

Abstract

PURPOSEAllogeneic hematopoietic cell transplantation (HCT) improves outcomes for patients with AML harboring an internal tandem duplication mutation of FLT3 (FLT3-ITD) AML. These patients are routinely treated with a FLT3 inhibitor after HCT, but there is limited evidence to support this. Accordingly, we conducted a randomized trial of post-HCT maintenance with the FLT3 inhibitor gilteritinib (ClinicalTrials.gov identifier: NCT02997202) to determine if all such patients benefit or if detection of measurable residual disease (MRD) could identify those who might benefit.METHODSAdults with FLT3-ITD AML in first remission underwent HCT and were randomly assigned to placebo or 120 mg once daily gilteritinib for 24 months after HCT. The primary end point was relapse-free survival (RFS). Secondary end points included overall survival (OS) and the effect of MRD pre- and post-HCT on RFS and OS.RESULTSThree hundred fifty-six participants were randomly assigned post-HCT to receive gilteritinib or placebo. Although RFS was higher in the gilteritinib arm, the difference was not statistically significant (hazard ratio [HR], 0.679 [95% CI, 0.459 to 1.005]; two-sided P =.0518). However, 50.5% of participants had MRD detectable pre- or post-HCT, and, in a prespecified subgroup analysis, gilteritinib was beneficial in this population (HR, 0.515 [95% CI, 0.316 to 0.838]; P =.0065). Those without detectable MRD showed no benefit (HR, 1.213 [95% CI, 0.616 to 2.387]; P =.575).CONCLUSIONAlthough the overall improvement in RFS was not statistically significant, RFS was higher for participants with detectable FLT3-ITD MRD pre- or post-HCT who received gilteritinib treatment. To our knowledge, these data are among the first to support the effectiveness of MRD-based post-HCT therapy.

Published
2024

18. Clinical outcomes of etoposide and cytarabine as consolidation in elderly patients with primary CNS lymphoma.

Author

Kim, Yu Ri, Cho, Hyunsoo, Kim, Soo-Jeong, Chung, Haerim, Kook, Hye Won, Jang, Ji Eun, Cheong, June-Won, and Kim, Jin Seok

Subjects
FEBRILE neutropenia, RESEARCH funding, TREATMENT effectiveness, RETROSPECTIVE studies, ETOPOSIDE, CYTARABINE, CENTRAL nervous system tumors, THROMBOCYTOPENIA, CONSOLIDATION chemotherapy, PROGRESSION-free survival, OVERALL survival
Abstract

Background A consolidation strategy has not been established for transplant-ineligible elderly patients with primary central nervous system lymphoma (PCNSL). In this study, we aimed to retrospectively evaluate the clinical outcomes of etoposide and cytarabine (EA) as consolidation chemotherapy for transplant-ineligible patients with PCNSL following high-dose methotrexate (MTX)-based induction chemotherapy. Materials and Methods Between 2015 and 2021, newly diagnosed transplant-ineligible patients with PCNSL with diffuse large B-cell lymphoma were consecutively enrolled. All enrolled patients were over 60 years old and received EA consolidation after achieving a complete or partial response following induction chemotherapy. Results Of the 85 patients who achieved a complete or partial response to MTX-based induction chemotherapy, 51 received EA consolidation chemotherapy. Among the 25 (49.0%, 25/51) patients in partial remission before EA consolidation, 56% (n  = 14) achieved complete remission after EA consolidation. The median overall survival and progression-free survival were 43 and 13 months, respectively. Hematological toxicities were most common, and all patients experienced grade 4 neutropenia and thrombocytopenia. Forty-eight patients experienced febrile neutropenia during consolidation chemotherapy, and 4 patients died owing to treatment-related complications. Conclusion EA consolidation chemotherapy for transplant-ineligible, elderly patients with PCNSL improved response rates but showed a high relapse rate and short progression-free survival. The incidences of treatment-related mortality caused by hematologic toxicities and severe infections were very high, even after dose modification. Therefore, the use of EA consolidation should be reconsidered in elderly patients with PCNSL. [ABSTRACT FROM AUTHOR]

Published
2024
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27. P777: EFFICACY AND SAFETY OF ROMIPLOSTIM COMBINED WITH CYCLOSPORINE A AS A FIRST-LINE TREATMENT IN PATIENTS WITH APLASTIC ANEMIA: A PHASE 2/3 CLINICAL TRIAL.

Author

Chiba, Shigeru, primary, Wook Lee, Jong, additional, Ho Jang, Jun, additional, Yoon, Sung-Soo, additional, Oshikawa, Gaku, additional, Usuki, Kensuke, additional, Mun, Yeung-Chul, additional, Kawakita, Toshiro, additional, Imada, Kazunori, additional, Cheong, June-Won, additional, Noshiro, Masayoshi, additional, Matsuda, Akira, additional, Ozawa, Keiya, additional, Mitani, Kinuko, additional, Kanda, Yoshinobu, additional, and Nakao, Shinji, additional

Published
2023
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28. P1042: COMPARISON OF THE RESPONSE TO ROPEGINTERFERON ALFA-2B IN HYDROXYUREA NAÏVE VERSUS RESISTANCE/INTOLERANCE POLYCYTHEMIA VERA: THE KOREAN SINGLE-ARM, OPEN-LABEL MULTICENTER STUDY

Author

Lee, Sung-Eun, primary, Yoon, Sung-Soo, additional, Yang, Deok-Hwan, additional, Lee, Gyeong-Won, additional, Yun Yoon, Seug, additional, Kyun Sohn, Sang, additional, Shin, Ho-Jin, additional, Hwa Bae, Sung, additional, Won Choi, Chul, additional, Choi, Eun-Ji, additional, Cheong, June-Won, additional, Bang, Soo-Mee, additional, Seong Park, Joon, additional, Joong Oh, Suk, additional, Park, Young, additional, and Hoon Park, Young, additional

Published
2023
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32. RNA sequencing as an alternative tool for detecting measurable residual disease in core-binding factor acute myeloid leukemia

Author

Kim, TaeHyung, Moon, Joon Ho, Ahn, Jae-Sook, Ahn, Seo-Yeon, Jung, Sung-Hoon, Yang, Deok-Hwan, Lee, Je-Jung, Shin, Myung-Geun, Choi, Seung Hyun, Lee, Ja-yeon, Tyndel, Marc S., Lee, Hui Young, Kim, Kyoung Ha, Cai, Yu, Lee, Yoo Jin, Sohn, Sang Kyun, Min, Yoo Hong, Cheong, June-Won, Kim, Hyeoung-Joon, Zhang, Zhaolei, and Kim, Dennis Dong Hwan

Published
2020
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42. Momelotinib versus danazol in symptomatic patients with anaemia and myelofibrosis (MOMENTUM): results from an international, double-blind, randomised, controlled, phase 3 study

Author

Verstovsek, Srdan, primary, Gerds, Aaron T, additional, Vannucchi, Alessandro M, additional, Al-Ali, Haifa Kathrin, additional, Lavie, David, additional, Kuykendall, Andrew T, additional, Grosicki, Sebastian, additional, Iurlo, Alessandra, additional, Goh, Yeow Tee, additional, Lazaroiu, Mihaela C, additional, Egyed, Miklos, additional, Fox, Maria Laura, additional, McLornan, Donal, additional, Perkins, Andrew, additional, Yoon, Sung-Soo, additional, Gupta, Vikas, additional, Kiladjian, Jean-Jacques, additional, Granacher, Nikki, additional, Lee, Sung-Eun, additional, Ocroteala, Luminita, additional, Passamonti, Francesco, additional, Harrison, Claire N, additional, Klencke, Barbara J, additional, Ro, Sunhee, additional, Donahue, Rafe, additional, Kawashima, Jun, additional, Mesa, Ruben, additional, Abulafia, Adi Shacham, additional, Andreasson, Bjorn, additional, Angona, Anna, additional, Ayala, Rosa, additional, Bang, Soo-Mee, additional, Bank, Bruce, additional, Barraco, Fiorenza, additional, Beggiato, Eloise, additional, Benghiat, Fleur Samantha, additional, Bonifacio, MassimiliaNo, additional, Bories, Claire, additional, Borsaru, Gabriela, additional, Brabrand, Mette, additional, Braester, Andrei, additional, Broliden, Andes, additional, Buxhofer-Ausch, Veronika, additional, Cambier, Nathalie, additional, Caramella, Marianna, additional, Carpentier, Benjamin, additional, Cascavilla, Nicola, additional, Castellano, Maria Giraldo, additional, Chang, Hung, additional, Chen, Chih-Cheng, additional, Cheong, June-Won, additional, Choi, Yunsuk, additional, Choi, Philip, additional, Corsetti, Maria Teresa, additional, Cuadrado, Isabel Montero, additional, Cunningham, Julia, additional, Damaj, Gandhi Laurent, additional, De Stefano, Valerio, additional, Delage, Robert, additional, Delgado, Regina Garcĺa, additional, Diaz, Jose Miguel Torregrosa, additional, Dombi, Péter, additional, Dubruille, Viviane, additional, Egyed, Miklós, additional, El Fassi, Daniel, additional, Elinder-Camburn, Anna, additional, Elli, Elena Maria, additional, Ellis, Martin, additional, Fava, Carmen, additional, Fazal, Salman, additional, Fleischman, Angela, additional, Foltz, Lynda, additional, Fox, Laura, additional, Gabrail, Nashat, additional, Garcĺa-Gutiérrez, Jose Valentĺn, additional, Gerds, Aaron, additional, Girault, Stephane, additional, Gisslinger, Heinz, additional, Gluvacov, Alexandru, additional, Göthert, Joachim, additional, Hadjiev (Hadzhiev), Evgeni (Evgueniy), additional, Hafraoui, Kaoutar, additional, Hamed, Aryan, additional, Harrison, Claire, additional, Hasselbalch, Hans, additional, Hauser, Hanns, additional, Heaney, Mark, additional, Hebart, Holger, additional, Hernandez Rivas, Jesus Maria, additional, Higuero Saavedra, Victor, additional, Hillis, Christopher, additional, Hou, Hsin-An, additional, How, Jonathan, additional, Huang, Daniel, additional, Hus, Marek, additional, Illés, Arpad, additional, Isidori, Alessandro, additional, Ivanov, Vadim, additional, Johansson, Peter, additional, Jung, Chul Won, additional, Kirgner, Ilya, additional, Koren-Michowitz, Maya, additional, Koschmieder, Steffen, additional, Kosztolanyi, Szabolcs Ors, additional, Kreiniz, Natalia, additional, Kuykendall, Andrew, additional, Lambert, Jonathan, additional, Laribi, Kamel, additional, Lascaux, Axelle, additional, Lavie, Noa, additional, Lazaroiu, Mihaela, additional, Leahy, Michael, additional, Lech-Maranda, Ewa, additional, Lee, Won Sik, additional, Legrand, Ollivier, additional, Lemoli, Roberto, additional, Liang, James, additional, Lim, Sung-Nam, additional, Loschi, Michael, additional, Lucchesi, Alessandro, additional, Macarie, Ioan, additional, Marolleau, Jean-Pierre, additional, Martelli, Maurizio, additional, Mayer, Jiri, additional, McCloskey, James, additional, McDermott, Christopher, additional, McMahon, Brandon, additional, Mehta, Priyanka, additional, Mikala, Gábor, additional, Milojkovic, Dragana, additional, Mineur, Philippe, additional, Mishchenko, Elena, additional, Moon, Joon Ho, additional, Nagy, Zsolt, additional, Narayanan, Srinivasan, additional, O'Connell, Casey, additional, Oh, Stephen, additional, Ojeda-Uribe, Mario, additional, Ong, Kiat Hoe, additional, Otegbeye, Folashade, additional, Palmer, Jeanne, additional, Pane, Fabrizio, additional, Patriarca, Andrea, additional, Pietrantuono, Giuseppe, additional, Plander, Mark, additional, Platzbecker, Uwe, additional, Prasad, Ritam, additional, Prejzner, Witold, additional, Rachow, Tobias, additional, Radinoff, Atanas, additional, Rejtő, László, additional, Rinaldi, Ciro, additional, Robak, Tadeusz, additional, Rodriguez, Maria Angeles Fernandez, additional, Ronson, Aaron, additional, Ross, David, additional, Sacha, Tomasz, additional, Sadjadian, Parvis, additional, Salar, Antonio, additional, Santillana, Guillermo Sanz, additional, Scheid, Christof, additional, Schmidt, Aline, additional, Severinsen, Marianne Tang, additional, Stoeva, Vera, additional, Szwedyk, Paweł, additional, Tiribelli, Mario, additional, Trautmann-Grill, Karolin, additional, Trottier, Amy, additional, Tzvetkov, Nikolay, additional, van Droogenbroeck, Janusz, additional, Vannucchi, Alessandro, additional, Verstovsek, Srdan, additional, Vianelli, Nicola, additional, von Bubnoff, Nikolas, additional, Wolf, Dominik, additional, Woszczyk, Dariusz, additional, Woźny, Tomasz, additional, Wróbel, Tomasz, additional, Xicoy, Blanca, additional, and Yeh, Su-Peng, additional

Published
2023
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45. Salvage therapy for acute chemorefractory leukemia by allogeneic stem cell transplantation: the Korean experience

Author

Yoo, Shin Hye, Koh, Youngil, Kim, Dae-Young, Lee, Jung-Hee, Lee, Je-Hwan, Lee, Kyoo-Hyung, Yoon, Sung-Soo, Park, Seonyang, Park, Sung-Kyu, Hong, Dae-Sik, Yi, Hyeon Gyu, Kim, Chul-Soo, Jang, Ji Eun, Cheong, June-Won, Moon, Joonho, Min, Yoo Hong, Sohn, Sang Kyun, Kim, Inho, and for the Korean Society of Blood and Marrow Transplantation

Published
2017
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46. A Potent Small Molecule Inhibitor of FLT3, PHI-101 Overcomes Resistance in Acute Myeloid Leukemia: Efficacy and PK/PD Profile in Phase 1 First in Human Study

Author

Yoon, Sung-Soo, primary, Shin, Dong-Yeop, additional, Lee, Je-Hwan, additional, Jang, Jun Ho, additional, Cheong, June-Won, additional, Shin, Ho-Jin, additional, Lee, Jeong-Ok, additional, Choi, Yunsuk, additional, Clarey, Joseph, additional, Im, Jeejin, additional, Kim, Suntae, additional, Nam, Ky-Youb, additional, Kim, Kyu-Tae, additional, Han, June, additional, Yoon, Jeong Hyeok, additional, Nguyen, Bao, additional, Li, Li, additional, and Small, Donald, additional

Published
2022
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47. A Single-Arm, Open-Label, Multicenter Study to Assess Molecular Response of P1101 Therapy in Patients with Polycythemia Vera and Elevated Hematocrit

Author

Lee, Sung-Eun, primary, Yoon, Sung-Soo, additional, Yang, Deok-Hwan, additional, Lee, Gyeong-Won, additional, Yoon, Seug Yun, additional, Sohn, Sang Kyun, additional, Shin, Ho-Jin, additional, Bae, Sung Hwa, additional, Choi, Chul Won, additional, Choi, Eun-Ji, additional, Cheong, June-Won, additional, Bang, Soo-Mee, additional, and Park, Joon Seong, additional

Published
2022
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49. High-Dose Etoposide Plus Granulocyte Colony-Stimulating Factor as an Effective Chemomobilization Regimen for Autologous Stem Cell Transplantation in Patients with Non-Hodgkin Lymphoma Previously Treated with CHOP-based Chemotherapy: A Study from the Consortium for Improving Survival of Lymphoma

Author

Hyun, Shin Young, Cheong, June-Won, Kim, Soo-Jeong, Min, Yoo Hong, Yang, Deok-Hwan, Ahn, Jae-Sook, Lee, Won-Sik, Ryoo, Hun-Mo, Do, Young Rok, Lee, Ho Sup, Lee, Jae Hoon, Oh, Sung Yong, Suh, Cheolwon, Yhim, Ho-Young, and Kim, Jin Seok

Published
2014
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50. Utility of Plasma Microbial Cell-Free DNA Whole-Genome Sequencing for Diagnosis of Invasive Aspergillosis in Patients With Hematologic Malignancy or COVID-19.

Author

Lee, Ki Hyun, Won, Dongju, Kim, Jinnam, Lee, Jung Ah, Kim, Chang Hyup, Kim, Jung Ho, Jeong, Su Jin, Ku, Nam Su, Choi, Jun Yong, Yeom, Joon-Sup, Cho, Hyunsoo, Chung, Haerim, Cheong, June-Won, Lee, Seung-Tae, Jang, Ji Eun, Shin, Saeam, and Ahn, Jin Young

Subjects
CELL-free DNA, NUCLEOTIDE sequencing, HEMATOLOGIC malignancies, DNA sequencing, ASPERGILLOSIS, PULMONARY aspergillosis, CORONAVIRUS diseases
Abstract

Background We evaluated the clinical accuracy and utility of whole-genome sequencing (WGS) of plasma microbial cell-free DNA (cfDNA) as a novel noninvasive method in diagnosing invasive aspergillosis (IA) in patients with hematologic malignancy (HM) or coronavirus disease 2019 (COVID-19). Methods Adults with HM or COVID-19 and suspected IA were recruited. IA cases were retrospectively diagnosed according to EORTC/MSG definitions and ECMM/ISHAM criteria for HM and COVID-19 patients, respectively. The results of cfDNA WGS were compared with the conventional diagnosis. Results Microbial cfDNA WGS was performed 53 times from 41 participants (19 from HM, 16 from COVID-19, and 7 from the control group). In participants with HM, Aspergillus cfDNA was detected in 100% of proven IA and 91.7% of probable IA cases. In participants with COVID-19, 50.0% of probable IA were positive for Aspergillus in cfDNA WGS. Concordance between Aspergillus cfDNA detection and proven/probable IA conventional diagnosis was significantly higher in participants with HM than in those with COVID-19. IA diagnosed using EORTC/MGS definitions showed significantly high concordance between Aspergillus cfDNA detection and proven/probable IA. Conclusions Aspergillus cfDNA detection strongly correlated with proven/probable IA diagnosed using EORTC/MSG definitions and could be used as an additional diagnostic tool for IA. [ABSTRACT FROM AUTHOR]

Published
2023
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