48 results on '"Chenlu He"'
Search Results
2. Causal role of immune cells in schizophrenia: Mendelian randomization (MR) study
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Chengdong Wang, Dongdong Zhu, Dongjun Zhang, Xiaowei Zuo, Lei Yao, Teng Liu, Xiaodan Ge, Chenlu He, Yuan Zhou, and Ziyuan Shen
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Schizophrenia ,Immunity ,Causal inference ,Brain ,MR analysis ,Sensitivity ,Psychiatry ,RC435-571 - Abstract
Abstract Background Complex immune-brain interactions that affect neural development, survival and function might have causal and therapeutic implications for psychiatric illnesses. However, previous studies examining the association between immune inflammation and schizophrenia (SCZ) have yielded inconsistent findings. Methods Comprehensive two-sample Mendelian randomization (MR) analysis was performed to determine the causal association between immune cell signatures and SCZ in this study. Based on publicly available genetic data, we explored causal associations between 731 immune cell signatures and SCZ risk. A total of four types of immune signatures (median fluorescence intensities (MFI), relative cell (RC), absolute cell (AC), and morphological parameters (MP)) were included. Comprehensive sensitivity analyses were used to verify the robustness, heterogeneity, and horizontal pleiotropy of the results. Results After FDR correction, SCZ had no statistically significant effect on immunophenotypes. It was worth mentioning some phenotypes with unadjusted low P-values, including FSC-A on NKT (β = 0.119, 95% CI = 0.044 ~ 0.194, P = 0.002), DN (CD4-CD8-) NKT %T cell (β = 0.131, 95% CI = 0.054 ~ 0.208, P = 9.03 × 10− 4), and SSC-A on lymphocytes (β = 0.136, 95% CI = 0.059 ~ 0.213, P = 5.43 × 10− 4). The causal effect of SCZ IgD on transitional was estimated to 0.127 (95% CI = 0.051 ~ 0.203, P = 1.09 × 10− 3). SCZ also had a causal effect on IgD+ %B cell (β = 0.130, 95% CI = 0.054 ~ 0.207, P = 8.69 × 10− 4), and DP (CD4+CD8+) %T cell (β = 0.131, 95% CI = 0.054 ~ 0.207, P = 8.05 × 10− 4). Furthermore, four immunophenotypes were identified to be significantly associated with SCZ risk: naive CD4+ %T cell (OR = 0.986, 95% CI = 0.979 ~ 0.992, P = 1.37 × 10− 5), HLA DR on CD14− CD16− (OR = 0.738 (95% CI = 0.642 ~ 0.849, P = 2.00 × 10− 5), CD33dim HLA DR+ CD11b− AC (OR = 0.631, 95% CI = 0.529 ~ 0.753, P = 3.40 × 10− 7) and activated & resting Treg % CD4 Treg (OR = 0.937, 95% CI = 0.906 ~ 0.970, P = 1.96 × 10− 4). Conclusions Our study has demonstrated the close connection between immune cells and SCZ by genetic means, thus providing guidance for future clinical research.
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- 2023
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3. Factors associated with the mental health status of pregnant women in China: A latent class analysis
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Yifei Pei, Qian Chen, Ying Zhang, Chenlu He, Jingjing Wang, Jie Tang, Hao Hou, Ziqing Zhu, Xunbao Zhang, and Wei Wang
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pregnant women ,mental health ,latent class analysis ,China ,psychological symptoms ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundPrenatal mental health is a neglected public health issue that places pregnant women at a higher risk for mental disorders. The purpose of this study was to investigate the influencing factors of prenatal mental disorders and provide a scientific basis to guide and promote the mental health of pregnant women.MethodsThe study sample comprised 973 women in their first pregnancy, who were in their second trimester and third trimester, who underwent obstetric outpatient checkups at the Maternal and Child Health Hospital in Huai'an, who were recruited in the survey that was conducted from July to December 2017. The Chinese mental health scale (CMHS) was used to assess the mental health of pregnant women. The present study uses the chi-square test to compare the rates of class with different demographic variables, a latent class analysis to identify psychological symptoms, and multiple logistic regression analysis to examine whether the demographics predicted class membership.ResultsThe chi-square test results showed that participants who reported feeling different in the perinatal period (χ2 = 6.35, P = 0.04), having marital satisfaction (χ2 = 15.8, P < 0.001), with an in-law relationship (χ2 = 29.43, P < 0.001), with a friend relationship (χ2 = 24.81, P < 0.001), with basic diseases (χ2 = 8.04, P = 0.02), and taking birth control pills (χ2 = 8.97, P = 0.01) have different probabilities of being classified. Three latent classes were identified: the high symptoms group (6.89%), the moderate symptoms group (20.56%), and the low symptoms group (72.56%). Pregnant women in the third trimester [odds ratio (OR) = 1.83, 95% confidence interval (CI): 1.04–3.25, P = 0.04], with a poor in-law relationship (OR = 2.82, 95% CI:1.45–5.51, P = 0.002), with a bad friend relationship (OR = 3.17, 95% CI: 1.31–7.71, P = 0.01), and who had basic diseases (OR = 1.70, 95% CI: 1.00–2.90, P = 0.04) tended to be classified under the high symptoms group than under the low symptoms group. Pregnant women with a bad friend relationship (OR = 2.15, 95% CI: 1.08–4.28, P = 0.03) and taking birth control pills (OR = 1.51, 95% CI: 1.08–2.11, P = 0.02) were more likely to be placed under the moderate symptoms group than under the low symptoms group.ConclusionsA pregnant woman's mental health status factors include feeling different in the perinatal period, those with marital satisfaction, those with an in-law relationship, those with a friend relationship, those with basic diseases, and those taking birth control pills. To ensure a smooth progress of pregnancy and promote the physical and mental health of pregnant women, psychological screening and psychological intervention measures should be strengthened.
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- 2023
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4. The association between family relationships and depressive symptoms among pregnant women: A network analysis
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Jingjing Wang, Yifei Pei, Jie Tang, Qian Chen, Chenlu He, Ying Zhang, Hao Hou, Xunbao Zhang, and Wei Wang
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family relationship ,depression ,network analysis ,pregnant women ,mental health ,Psychiatry ,RC435-571 - Abstract
BackgroundDepression of pregnant women has been a growing concern in recent years, and previous research has found that family relationships are strongly associated with depression. From a network perspective, family relationships and depression can be conceptualized as the result of interactions between individual symptoms. This research approach can elucidate the structure and mechanisms of the relationship between individual symptoms within the two groups.MethodsA total of 990 participants were recruited from the obstetrics outpatient clinic of Maternal and Child Health Hospital in Huai'an through a randomized whole-group sampling. Respondents' depressive symptoms and family relationships were self-reported using questionnaire, and the structure of the family relationship-depressive symptoms network and related centrality indicators were examined for this sample.ResultsThe results of the network analysis suggested that the most influential symptoms in the network of family relationship-depressive symptoms were worry, feeling worthless, equal status with husband and couple relationship. And equal status with husband was the most prominent bridging symptoms in this study. The whole network was robust in both stability and accuracy tests.LimitationsInformation was obtained from subjects' self-reports, which may be subject to information bias. As a cross-sectional study, no causal link between family relationships and depressive symptoms can be established.ConclusionWorry, feeling worthless, equal status with husband and couple relationship are central symptoms of the family relationship-depressive symptoms network structure in pregnant women. Timely and systematic multilevel interventions targeting the central symptoms may be effective in alleviating the onset of depressive symptoms in women during this period.
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- 2022
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5. The rise of halide perovskite semiconductors
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Chenlu He and Xiaogang Liu
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Applied optics. Photonics ,TA1501-1820 ,Optics. Light ,QC350-467 - Abstract
Abstract Advances in metal-halide perovskite semiconductors have significantly influenced light-current conversion technologies. The excellent structural and compositional tunability of perovskites, coupled with their exceptional quantum yields for photoluminescence, make them a promising candidate for optoelectronic devices.
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- 2023
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6. A Novel Prognostic Index Model for Adult Hemophagocytic Lymphohistiocytosis: A Multicenter Retrospective Analysis in China
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Ziyuan Shen, Yingliang Jin, Qian Sun, Shuo Zhang, Xi Chen, Lingling Hu, Chenlu He, Ying Wang, Qinhua Liu, Hao Zhang, Xin Liu, Ling Wang, Jun Jiao, Yuqing Miao, Weiying Gu, Fei Wang, Chunling Wang, Yuye Shi, Jingjing Ye, Taigang Zhu, Cai Sun, Xuguang Song, Linyan Xu, Dongmei Yan, Haiying Sun, Jiang Cao, Depeng Li, Zhenyu Li, Zhao Wang, Shuiping Huang, Kailin Xu, and Wei Sang
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hemophagocytic lymphohistiocytosis ,adult ,multicenter ,prognostic model ,stratification ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Hemophagocytic lymphohistiocytosis (HLH) is an immune disorder with rapid progression and poor survival. Individual treatment strategy is restricted, due to the absence of precise stratification criteria. In this multicenter retrospective study, we aimed to develop a feasible prognostic model for adult HLH in China. A total of 270 newly diagnosed patients of adult HLH were retrieved from the Huaihai Lymphoma Working Group (HHLWG), of whom 184 from 5 medical centers served as derivation cohort, and 86 cases from 3 other centers served as validation cohort. X-Tile program and Maxstat analysis were used to identify optimal cutoff points of continuous variables; univariate and multivariate Cox analyses were used for variable selection, and the Kaplan–Meier curve was used to analyze the value of variables on prognosis. The C-index, Brier Score, and calibration curve were used for model validation. Multivariate analysis showed that age, creatinine, albumin, platelet, lymphocyte ratio, and alanine aminotransferase were independent prognostic factors. By rounding up the hazard ratios from 6 significant variables, a maximum of 9 points was assigned. The final scoring model of HHLWG-HPI was identified with four risk groups: low risk (≤3 pts), low-intermediate risk (4 pts), high-intermediate risk (5-6 pts), and high risk (≥7 pts), with 5-year overall survival rates of 68.5%, 35.2%, 21.3%, and 10.8%, respectively. The C-indexes were 0.796 and 0.758 in the derivation and validation cohorts by using a bootstrap resampling program. In conclusion, the HHLWG-HPI model provides a feasible and accurate stratification system for individualized treatment strategy in adult HLH.
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- 2022
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7. Highly enantioselective photo-polymerization enhanced by chiral nanoparticles and in situ photopatterning of chirality
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Chenlu He, Zeyu Feng, Sizhen Shan, Mengqiao Wang, Xin Chen, and Gang Zou
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Science - Abstract
Chiral nanoparticles are capable of ultrasensitive detection, characterization, and asymmetric synthesis of chiral organic and biological molecules. Here, the authors use silver nanoparticles modified with cysteine, as the sole chiral source, and unpolarized UV light, to form polydiacetylene with high chiral asymmetry from achiral diacetylene monomers.
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- 2020
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8. The Addition of Ferritin Enhanced the Prognostic Value of International Prognostic Index in Diffuse Large B‐Cell Lymphoma
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Ziyuan Shen, Shuo Zhang, Meng Zhang, Lingling Hu, Qian Sun, Chenlu He, Dongmei Yan, Jingjing Ye, Hao Zhang, Ling Wang, Weiying Gu, Yuqing Miao, Qinhua Liu, Changli Ouyang, Junfeng Zhu, Chunling Wang, Taigang Zhu, Shuiping Huang, and Wei Sang
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ferritin ,DLBCL ,International Prognostic Index ,prognosis ,nomogram ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Diffuse large B-cell lymphoma (DLBCL) is a highly heterogeneous non-Hodgkin lymphoma, and the prognosis of DLBCL patients is widely affected by multivariables. Clinical-factors-based prognostic systems stratify the prognosis of DLBCL with certain limitations, and the value of ferritin on the prognosis of DLBCL is unclear. In this study, 225 cases were retrieved from 4 centers of Huaihai Lymphoma Working Group (HHLWG) as the derivation cohort, and 66 cases were from the other 6 centers of HHLWG as external validation cohort. X-Tile program divided ferritin into three groups when applying 175.00 and 391.90 μg/L as the optimal cutoff points. Based on multivariable analysis, ferritin appeared to be a stronger predictor. A total of three variables (ferritin, age, and lactate dehydrogenase) were included for the development of the nomogram. The C-indexes were 0.73 and 0.70 in the derivation and validation cohort, and the calibration curve showed the consistency between the nomogram prediction and the actual observation. In conclusion, Ferritin-based nomogram enhanced the prognostic value of IPI in DLBCL.
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- 2022
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9. Benevolent Childhood Experiences and Depressive Symptoms Among Chinese Undergraduates: A Moderated Mediation Model Examining the Roles of Uncertainty Stress and Family Relationship
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Caiyi Zhang, Wei Wang, Yifei Pei, Ying Zhang, Chenlu He, Jingjing Wang, Xiuyin Gao, and Hao Hou
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benevolent childhood experiences ,depressive symptoms ,uncertainty stress ,family relationship ,undergraduates ,Public aspects of medicine ,RA1-1270 - Abstract
Background: The evidence on the association between benevolent childhood experience (BCE) and depressive symptoms in students is complex. This study aims to explore the underlying mediation mechanism of BCE toward depressive symptoms and whether this link was moderated by the family relationship among Chinese undergraduates.Methods: From March 2021 to May 2021, a cross-sectional study was conducted in China, and 1821 undergraduates were recruited in this study. Participants were asked to complete a self-reported electronic questionnaire. The software SPSS PROCESS macro was used to test the mediation and mediated moderated modeling analysis.Results: Mediation analysis indicated that uncertainty stress (US) partly mediated the link between BCE and depressive symptoms (indirect effect = −0.47, 95% bootstrap CI = −0.55, −0.39). The indirect effect of the US accounted for 39.63% of the total variance in depression. Moderation analysis indicated that the association between the US and depressive symptoms was significantly modified by family relationships (interact effect = −0.019, P < 0.001). An integrative moderated mediation analysis indicated that the indirect effect from BCE to depressive symptoms through the US was also moderated by family relationships (interact effect = −0.012, P = 0.014).Conclusion: Uncertainty stress plays a key role in bridging BCE and depressive symptoms while the family relationship can buffer the impact of the US on depressive symptoms among Chinese undergraduates. Enhancing tolerance of uncertainty and improving family relationships are needed to protect undergraduates from depressive symptoms.
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- 2021
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10. Development and Validation of a Novel Prognostic Nomogram for CD5-Positive Diffuse Large B-Cell Lymphoma: A Retrospective Multicenter Study in China
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Ziyuan Shen, Ling Wang, Bingpei Zhang, Tianci Li, Dashan Li, Chenlu He, Yuhao Xue, Ying Wang, Bingzong Li, Qinhua Liu, Hao Zhang, Weiying Gu, Fei Wang, Chunling Wang, Yuye Shi, Jingjing Ye, Taigang Zhu, Yuqing Miao, Shuiping Huang, and Wei Sang
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CD5-positive ,DLBCL ,nomogram ,prognosis ,validation ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
BackgroundCD5-positive diffuse large B-cell lymphoma (CD5+ DLBCL) is a rare subtype of DLBCL with invasive clinical features and poor prognosis. Current clinical variables based on prognostic systems for DLBCL are inadequate to accurately stratify the prognosis of CD5+ DLBCL.MethodsA total of 195 CD5+ DLBCL patients were retrospectively recruited from nine centers in Huaihai Lymphoma Working Group. MaxStat analysis was used to identify optimal cutoff points for continuous variables; univariable and multivariable Cox analyses were used for variable selection; Kaplan–Meier curve was used to analyze the value of variables on prognosis; and C-index, Brier score, and decision curve analysis were measured for predicting model performance.ResultsThe derivation and validation cohorts consisted of 131 and 64 patients. Of the whole cohort, median age at diagnosis was 61 years, of whom 100 (51.28%) were males and the 5‐year overall survival rate was 42.1%. MYC, BCL-2, and the coexpression of MYC/BCL-2 could distinguish the survival of CD5+ DLBCL. Multivariable analysis showed that age, IPI, red blood cell count, neutrophil count, MYC expression, and hepatosplenomegaly were independent predictors, and the prognostic nomogram was developed. The C‐index of the nomogram was 0.809 in the derivation and 0.770 in the validation cohort. Decision curve analysis proved that compared with IPI, the specific nomogram showed a better identification in CD5+ DLBCL.ConclusionThe proposed nomogram provided a valuable tool for prognosis prediction in patients with CD5+ DLBCL.
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- 2021
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11. Dissymmetry enhancement in enantioselective synthesis of helical polydiacetylene by application of superchiral light
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Chenlu He, Guang Yang, Yan Kuai, Sizhen Shan, Lin Yang, Jingang Hu, Douguo Zhang, Qijin Zhang, and Gang Zou
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Science - Abstract
Superchiral light can be utilized to promote asymmetric photochemical reactions. Here the authors show that superchiral light imparts greater chiral bias to trigger asymmetric photo-polymerization reactions from initially achiral diacetylene monomers and enhanced optical dissymmetry in polydiacetylene films.
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- 2018
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12. Investigation of Blade Tip Shape for Improving VAWT Performance
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Yichen Jiang, Chenlu He, Peidong Zhao, and Tiezhi Sun
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vertical axis wind turbine ,tip vortex of blade ,supporting strut ,performance optimization ,computational fluid dynamics ,Naval architecture. Shipbuilding. Marine engineering ,VM1-989 ,Oceanography ,GC1-1581 - Abstract
Vertical axis wind turbine (VAWT) is a competitive power generation device due to structural simplicity, wind direction independence, no yaw mechanism required, easier maintenance, and lower noise emission. However, blade tip vortex will be generated at both ends of the blade during the rotation, resulting in torque loss and efficiency reduction. In this paper, computational fluid dynamics is used to study blade tip vortex and its reduction technique of a single-blade VAWT rotor in real scale. By monitoring the force and flow field at different heights of the blade, the influence ranges of tip vortex are obtained. The reduction effect of the bulkhead obtained from the blade profile curve is studied, and the size of the bulkhead is optimized. On the basis of adding the optimal bulkhead, the influence of the supporting strut is also explored. The joint action is obtained by changing the location of the supporting strut. The results show that the top supporting strut-bulkhead structure is the optimal position. The power-extraction efficiency of the rotor with this integrated structure is significantly improved at optimal tip speed ratios (TSRs) and higher TSRs.
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- 2020
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13. Author Correction: Dissymmetry enhancement in enantioselective synthesis of helical polydiacetylene by application of superchiral light
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Chenlu He, Guang Yang, Yan Kuai, Sizhen Shan, Lin Yang, Jingang Hu, Douguo Zhang, Qijin Zhang, and Gang Zou
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Science - Abstract
The original version of the Article contained an error in Figure 2 in which the TEM images in Fig. 2b and d were incorrect. Additionally, the seventh sentence of the ‘Mechanism for the dissymmetry enhancement of SCL field’ section of the Methods originally contained a mistake in the first equation. This has been corrected in both the PDF and HTML versions of the Article.
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- 2019
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14. Potential Genes Associated with the Survival of Lung Adenocarcinoma Were Identified by Methylation.
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Ziyuan Shen, Chenlu He, Haimiao Chen, Lishun Xiao, Yingliang Jin, and Shuiping Huang
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- 2020
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15. Unlocking the Potential of Halide Perovskites through Doping
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Chenlu He, Jian Qiu, Zhen Mu, and Xiaogang Liu
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General Chemistry - Published
- 2023
16. Secular trends of suicide risk for residents in mainland China (2004 to 2019): An updated age–period–cohort analysis
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Hao Hou, Bin Yu, Chenlu He, Guiyuan Li, Yifei Pei, Jingjing Wang, Jie Tang, Xinguang Chen, Xiuyin Gao, and Wei Wang
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Psychiatry and Mental health ,Clinical Psychology - Published
- 2023
17. Improved Nonsingular Fast Terminal Sliding Mode Control of Unmanned Underwater Hovering Vehicle
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Chenlu He and Zhengping Feng
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Multidisciplinary - Published
- 2022
18. An adaptive reaching law of chattering‐free discrete‐time sliding mode control for systems with external disturbance
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Xu Deng, Zhengping Feng, and Chenlu He
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Mathematics (miscellaneous) ,Control and Systems Engineering ,Electrical and Electronic Engineering - Published
- 2022
19. Attitude Stabilization of Unmanned Underwater Vehicle During Payloads Release
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Xu Deng, Zhengping Feng, Chenlu He, and Zhenhua Cui
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Multidisciplinary - Published
- 2023
20. Absolute asymmetric synthesis driven by circularly polarized Light
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Chenlu He and Yan Li
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General Chemistry - Published
- 2023
21. Chiral biosensing at both interband transition and plasmonic extinction regions using twisted-stacked nanowire arrays
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Zeyu Feng, Chenlu He, Yifan Xie, Chutian Zhang, Jiahe Li, Dingdong Liu, Zifan Jiang, Xin Chen, and Gang Zou
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Silver ,Nanowires ,Circular Dichroism ,Proteins ,Reproducibility of Results ,General Materials Science ,Nanostructures - Abstract
Chiral metal nanostructures that exhibit strong chiroptical properties and enhanced light-matter interactions have recently attracted great interest due to their potential applications including chiral sensing and asymmetric synthesis. Most studies in this field focused on chiral sensing using circular dichroism (CD) responses at the plasmonic extinction region. In comparison, little is known about their CD responses at interband transition regions and their utility in chiral biosensing. Herein, we constructed a series of twisted-stacked silver nanowire arrays (TNAs) featuring CD signals at both the interband transition and plasmonic extinction regions and that are independently controllable. These TNAs are highly sensitive towards protein secondary structures. Proteins containing more β-sheets are more sensitive toward strong chiral plasmonic fields, whereas proteins rich in α-helices tend to generate larger CD shifts at the interband transition region of TNAs. The mutually independent optical activities at the interband transition and plasmonic extinction regions complement each other, providing more sensitivity and reliability in chiral biosensing.
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- 2022
22. Disparity analysis and prognostic value of pretreatment whole blood <scp>Epstein‐Barr</scp> virus <scp>DNA</scp> load and Epstein‐Barr encoding region status in lymphomas: A retrospective multicenter study in Huaihai Lymphoma Working Group
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Weiying Gu, Taigang Zhu, Wei Sang, Yingliang Jin, Qinhua Liu, Fei Wang, Ziyuan Shen, Chenlu He, Fei Li, Manyu Dong, Ying Wang, Mingkang Yao, Lingling Hu, Hao Zhang, Ting Yin, and Shuiping Huang
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Oncology ,Cancer Research ,medicine.medical_specialty ,Proportional hazards model ,business.industry ,Follicular lymphoma ,medicine.disease_cause ,medicine.disease ,Epstein–Barr virus ,Virus ,Lymphoma ,Multicenter study ,immune system diseases ,hemic and lymphatic diseases ,Internal medicine ,medicine ,business ,Viral load ,Whole blood - Abstract
Elevated Epstein-Barr virus (EBV) DNA load is common in lymphomas. However, it remains unclear whether the disparity in viral load and its prognostic value in lymphomas are correlated with Epstein-Barr encoding region (EBER) status. In this retrospective multicenter study, we collected the data of pretreatment whole blood EBV DNA (pre-EBV DNA) and EBER status and evaluated their disparity and prognostic values in lymphomas. A total of 454 lymphoma patients from December 2014 to August 2020 were retrospectively retrieved. Mann-Whitney U test, Kruskal-Wallis test and Bonferroni's adjustment were used to explore the disparity of EBV DNA and EBER status in lymphomas. Time-dependent receiver operating characteristic analysis and MaxStat analysis were used to determine optimal cutoff points of pre-EBV DNA load. Univariable and multivariable Cox proportional hazards models were established for the estimation of prognostic factors. The positive rate of EBV DNA in natural killer T-cell lymphoma (NKTL) patients was higher than that in diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL) and Hodgkin lymphoma (HL) patients, and the median positive pre-EBV copy number of NKTL was also higher than that of FL and DLBCL. EBV DNA could clearly distinguish the prognosis of DLBCL, NKTL, HL and peripheral T-cell lymphoma, and the integration of EBER status and EBV DNA could differentiate the prognosis of HL patients. Multivariable results revealed that pre-EBV DNA load had an effect on the prognosis of NKTL, FL and DLBCL. The status of pre-EBV DNA and EBER were disparate. Whole blood pre-EBV DNA predicted the prognosis of lymphomas, and the combination of EBV and EBER status could differentiate the prognosis of HL.
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- 2021
23. Value of the prognostic nutritional index (PNI) in patients with newly diagnosed, CD5-positive diffuse large B-cell lymphoma: A multicenter retrospective study of the Huaihai Lymphoma Working Group
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Sha, Ma, Bingpei, Zhang, Tianyi, Lu, Dashan, Li, Tianci, Li, Ziyuan, Shen, Chenlu, He, Ying, Wang, Bingzong, Li, Hao, Zhang, Weiying, Gu, Chunling, Wang, Jingjing, Ye, Taigang, Zhu, Yuqing, Miao, Ling, Wang, Shuiping, Huang, Qinhua, Liu, and Wei, Sang
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Survival Rate ,Nutrition Assessment ,Humans ,Lymphoma, Large B-Cell, Diffuse ,Prognosis ,Retrospective Studies - Abstract
CD5-positive diffuse large B-cell lymphoma (DLBCL) is a clinically rare subtype of DLBCL with aggressive clinical manifestations and a poor prognosis. It has been demonstrated that the prognostic nutritional index (PNI), an indicator of nutritional status and systemic inflammation, is a significant prognostic factor for several types of lymphoma. The objective of this multicenter retrospective study was to explore the prognostic value of the PNI in patients with CD5-positive DLBCL.In total, 207 patients with CD5-positive DLBCL were recruited from 11 centers of the Huaihai Lymphoma Working Group. Maximally selected rank statistics analysis was used to identify optimal cutoff points for the PNI. A Cox proportional hazards model was used for univariable and multivariable analyses. Kaplan-Meier curves were used to calculate survival rates and draw survival curves, and the log-rank test was used to compare differences between groups.The median age at diagnosis was 61 years, and the 5-year overall survival rate was 47.5%. According to the maximally selected rank statistics analysis, a score of 49.7 was the optimal cutoff point for the PNI. Subgroup analysis showed that the PNI could re-stratify patients in BCL-2-negative, MYC-negative, high-intermediate-risk and high-risk International Prognostic Index, BCL-6-positive and BCL-6-negative, high Ki-67 score (≥0.9), Ann Arbor stage III/IV, Eastern Cooperative Oncology Group performance status ≥2, and germinal center B subgroups. Multivariable analysis revealed that PNI, age, Eastern Cooperative Oncology Group performance status, albumin level, and red blood cell count were independent prognostic factors for CD5-positive DLBCL.The PNI was a significant prognostic indicator for CD5-positive DLBCL and was able to re-stratify the prognosis for clinicopathologic subgroups of patients with CD5-positive DLBCL.
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- 2022
24. Near-Infrared Light-Triggered Enantioselective Photopolymerization of Polydiacetylene Films Assisted by Ag and NaYF4 Nanoparticles
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Fengya Lu, Yu Huang, Jiahe Li, Chutian Zhang, Xi Tang, Xin Chen, Zeyu Feng, Hongli Zhang, Douguo Zhang, Yifan Xie, Chenlu He, Xiangnan Wang, and Gang Zou
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Upconversion nanoparticles ,Near infrared light ,Materials science ,Photopolymer ,Upconversion luminescence ,Enantioselective synthesis ,Nanoparticle ,General Materials Science ,Photochemistry - Abstract
Recently, near-infrared (NIR) light-triggered photochemical reactions have been of particular interest owing to their potential in solar-driven chemistry and biomedical applications. However, asymm...
- Published
- 2021
25. Improved enantioselectivity in thiol–ene photopolymerization of sulphur-containing polymers with circularly polarized luminescence
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Liyang Zhao, Gang Zou, Xin Chen, Zeyu Feng, Manman Zhou, Xi-Sheng Wang, Chenlu He, Yan Li, Sizhen Shan, and Mengqiao Wang
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Polymers and Plastics ,Organic Chemistry ,Enantioselective synthesis ,Bioengineering ,Photochemistry ,Biochemistry ,chemistry.chemical_compound ,Monomer ,Photopolymer ,chemistry ,Thioether ,Enantiomer ,Luminescence ,Racemization ,Ene reaction - Abstract
Circularly polarized light (CPL)-triggered enantioselective thiol–ene reactions, which combine absolute asymmetric synthesis with click reactions, enable facile synthesis of optically active poly(thioether) directly from a racemic monomer. However, the enantioselectivity is low and the challenge of producing highly asymmetrical poly(thioether) with distinct circularly polarized luminescence has not been met to date. Herein, we show that the poor enantioselectivity can be largely attributed to the inevitable racemization of thiyl radicals during the growth cycle, and more importantly, it can be remedied by addition of achiral hydrogen atom donors (HAD). The enhancement in enantioselectivity of CPL-triggered thiol–ene reactions can be experimentally controlled by varying the reaction kinetics without introducing any chiral inducer other than CPL. A maximum excess of enantiomeric units (∼20%) in the final polymer chains could be obtained, and so-formed optically active poly(thioether) exhibited not only clusterization-triggered emission (CTE), but also fascinating circularly polarized luminescence for the first time.
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- 2021
26. Potential Genes Associated with the Survival of Lung Adenocarcinoma Were Identified by Methylation
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Chenlu He, Shuiping Huang, Haimiao Chen, Lishun Xiao, Yingliang Jin, and Ziyuan Shen
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Male ,Lung Neoplasms ,Nedd4 Ubiquitin Protein Ligases ,Suppressor of Cytokine Signaling Proteins ,Kaplan-Meier Estimate ,0302 clinical medicine ,Databases, Genetic ,Gene expression ,Protein Interaction Maps ,Likelihood Functions ,0303 health sciences ,Applied Mathematics ,General Medicine ,Methylation ,Prognosis ,Ankyrin Repeat ,Gene Expression Regulation, Neoplastic ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Modeling and Simulation ,Adenocarcinoma ,Female ,Algorithms ,Research Article ,Article Subject ,Computer applications to medicine. Medical informatics ,R858-859.7 ,Adenocarcinoma of Lung ,Computational biology ,Biology ,Polymorphism, Single Nucleotide ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,Text mining ,Biomarkers, Tumor ,medicine ,Humans ,Lung cancer ,Gene ,Aged ,Proportional Hazards Models ,030304 developmental biology ,Lung ,General Immunology and Microbiology ,Proportional hazards model ,business.industry ,Computational Biology ,DNA Methylation ,medicine.disease ,business ,Genome-Wide Association Study - Abstract
Background. Lung adenocarcinoma (LUAD) is the most common pathological type of lung cancer. The purpose of this study is to search for genes related to the prognosis of LUAD through methylation based on a linear mixed model (LMM). Methods. Gene expression, methylation, and survival data of LUAD patients were downloaded from the TCGA database. Based on the LMM model, the GEMMA algorithm was used to screen the predictive genes related to LUAD survival. The Cox model was used to further screen the predicted genes, and then, protein-protein interaction (PPI) network was constructed. Through the software plugin Cytoscape MCODE 3.8.0, the most closely related genes in the PPI network module were selected for in-depth biological function analysis to further explore the interaction and correlation between genes. Results. We screened out 97 predictive genes from 18,834 genes and eliminated one gene associated with lung squamous cell carcinoma from previous studies, leaving 96 genes. The MCODE and the Kaplan-Meier curve analysis were used to finally identify two genes ASB16 and NEDD4 that are related to the prognosis of LUAD. Conclusions. The newly identified two genes associated with the prognosis of LUAD may provide a basis for the treatment of patients.
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- 2020
27. Preparation of biomass-based N, P, and S co-doped porous carbon with high mesoporosity based on the synergistic effect of NaOH/thiourea and melamine phosphate and its application in high performance supercapacitors
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Xuan Yang, Yuhang Zheng, Chenlu He, Yijuan Qiu, Wenyan Hou, Beili Lu, Yandan Chen, Biao Huang, Jianhua Lv, and Guanfeng Lin
- Subjects
Fuel Technology ,Analytical Chemistry - Published
- 2023
28. A Novel Prognostic Index Model for Adult Hemophagocytic Lymphohistiocytosis: A Multicenter Retrospective Analysis in China
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Ziyuan Shen, Yingliang Jin, Qian Sun, Shuo Zhang, Xi Chen, Lingling Hu, Chenlu He, Ying Wang, Qinhua Liu, Hao Zhang, Xin Liu, Ling Wang, Jun Jiao, Yuqing Miao, Weiying Gu, Fei Wang, Chunling Wang, Yuye Shi, Jingjing Ye, Taigang Zhu, Cai Sun, Xuguang Song, Linyan Xu, Dongmei Yan, Haiying Sun, Jiang Cao, Depeng Li, Zhenyu Li, Zhao Wang, Shuiping Huang, Kailin Xu, and Wei Sang
- Subjects
Adult ,Lymphoma ,Immunology ,multicenter ,RC581-607 ,Prognosis ,Lymphohistiocytosis, Hemophagocytic ,Survival Rate ,stratification ,hemophagocytic lymphohistiocytosis ,Immunology and Allergy ,prognostic model ,Humans ,Immunologic diseases. Allergy ,Proportional Hazards Models ,Retrospective Studies - Abstract
Hemophagocytic lymphohistiocytosis (HLH) is an immune disorder with rapid progression and poor survival. Individual treatment strategy is restricted, due to the absence of precise stratification criteria. In this multicenter retrospective study, we aimed to develop a feasible prognostic model for adult HLH in China. A total of 270 newly diagnosed patients of adult HLH were retrieved from the Huaihai Lymphoma Working Group (HHLWG), of whom 184 from 5 medical centers served as derivation cohort, and 86 cases from 3 other centers served as validation cohort. X-Tile program and Maxstat analysis were used to identify optimal cutoff points of continuous variables; univariate and multivariate Cox analyses were used for variable selection, and the Kaplan–Meier curve was used to analyze the value of variables on prognosis. The C-index, Brier Score, and calibration curve were used for model validation. Multivariate analysis showed that age, creatinine, albumin, platelet, lymphocyte ratio, and alanine aminotransferase were independent prognostic factors. By rounding up the hazard ratios from 6 significant variables, a maximum of 9 points was assigned. The final scoring model of HHLWG-HPI was identified with four risk groups: low risk (≤3 pts), low-intermediate risk (4 pts), high-intermediate risk (5-6 pts), and high risk (≥7 pts), with 5-year overall survival rates of 68.5%, 35.2%, 21.3%, and 10.8%, respectively. The C-indexes were 0.796 and 0.758 in the derivation and validation cohorts by using a bootstrap resampling program. In conclusion, the HHLWG-HPI model provides a feasible and accurate stratification system for individualized treatment strategy in adult HLH.
- Published
- 2021
29. Development and Validation of a Novel Prognostic Nomogram for CD5-Positive Diffuse Large B-Cell Lymphoma: A Retrospective Multicenter Study in China
- Author
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Yuqing Miao, Wei Sang, Ling Wang, Chunling Wang, Shuiping Huang, Taigang Zhu, Bingpei Zhang, Weiying Gu, Hao Zhang, Yuye Shi, Fei Wang, Yuhao Xue, Ying Wang, Ziyuan Shen, Tianci Li, Jingjing Ye, Bingzong Li, Chenlu He, Dashan Li, and Qinhua Liu
- Subjects
Oncology ,Cancer Research ,medicine.medical_specialty ,Hepatosplenomegaly ,nomogram ,immune system diseases ,hemic and lymphatic diseases ,Internal medicine ,medicine ,RC254-282 ,Original Research ,validation ,business.industry ,CD5-positive ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Nomogram ,medicine.disease ,Lymphoma ,Brier score ,DLBCL ,Cohort ,Absolute neutrophil count ,prognosis ,CD5 ,medicine.symptom ,business ,Diffuse large B-cell lymphoma - Abstract
BackgroundCD5-positive diffuse large B-cell lymphoma (CD5+ DLBCL) is a rare subtype of DLBCL with invasive clinical features and poor prognosis. Current clinical variables based on prognostic systems for DLBCL are inadequate to accurately stratify the prognosis of CD5+ DLBCL.MethodsA total of 195 CD5+ DLBCL patients were retrospectively recruited from nine centers in Huaihai Lymphoma Working Group. MaxStat analysis was used to identify optimal cutoff points for continuous variables; univariable and multivariable Cox analyses were used for variable selection; Kaplan–Meier curve was used to analyze the value of variables on prognosis; and C-index, Brier score, and decision curve analysis were measured for predicting model performance.ResultsThe derivation and validation cohorts consisted of 131 and 64 patients. Of the whole cohort, median age at diagnosis was 61 years, of whom 100 (51.28%) were males and the 5‐year overall survival rate was 42.1%. MYC, BCL-2, and the coexpression of MYC/BCL-2 could distinguish the survival of CD5+ DLBCL. Multivariable analysis showed that age, IPI, red blood cell count, neutrophil count, MYC expression, and hepatosplenomegaly were independent predictors, and the prognostic nomogram was developed. The C‐index of the nomogram was 0.809 in the derivation and 0.770 in the validation cohort. Decision curve analysis proved that compared with IPI, the specific nomogram showed a better identification in CD5+ DLBCL.ConclusionThe proposed nomogram provided a valuable tool for prognosis prediction in patients with CD5+ DLBCL.
- Published
- 2021
30. Electrochemical sensing based on biomass-derived, hierarchical, porous carbon for simultaneous detection of dopamine and uric acid
- Author
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Xuan Yang, Chenlu He, Yijuan Qiu, Jiaming Bao, Pengfei Li, Yandan Chen, Xuechou Zhou, Biao Huang, and Xinyu Zheng
- Subjects
General Materials Science ,Condensed Matter Physics - Published
- 2022
31. Prevalence and the age of onset patterns of stroke in Jiangsu Province, China
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Chenlu He, Qian Chen, Ziyuan Shen, Ying Zhang, Hao Hou, Yifei Pei, Wei Wang, and Xunbao Zhang
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Psychiatry and Mental health ,Neurology (clinical) ,Dermatology ,General Medicine - Abstract
Little was known regarding the current age of onset patterns of stroke. This study aimed to examine the prevalence of stroke and explore the age of onset patterns of stroke in Jiangsu Province, China.Participants were recruited from April 2012 to April 2013 in Jiangsu Province, China. Survival analysis models were used to evaluate the hazards of stroke by a single year of age. Kaplan-Meier analysis and the log-rank test were used to explore the disparities of the age of onset patterns of stroke.This population-based study was conducted among 39,887 participants aged ≥ 18 years in Jiangsu Province, China. Of the 740 (1.9%) events of stroke, 13.2% suffered from hemorrhagic stroke (HS) and 86.8% suffered from ischemic stroke (IS). The prevalence of HS and IS were 0.3% and 1.7%, respectively. The estimated mean age of onset of stroke was 71.98 (95% CI: 71.97-71.99) years by the survival model. Up to age of 45 years, the estimated hazards of stroke onset were at a relatively low level. From the age of 45 years, the increases in hazards accelerated and peaked at age 75 years. Urban, smoking, and drinking males had a higher risk of stroke than their counterparts (P 0.05). However, no such difference was found among females.The findings emphasize the importance of implementing stroke prevention interventions in Jiangsu Province, China, especially for urban, smoking, and drinking males. It is of great significance to strengthen comprehensive management of health-related behaviors, including smoking cessation and moderate consumption of alcohol to have sustained beneficial effects on stroke risk. Chenlu He and Qian Chen contributed equally to this work.
- Published
- 2021
32. The Value of Prognostic Nutritional Index (PNI) on Newly Diagnosed Diffuse Large B-Cell Lymphoma Patients: A Multicenter Retrospective Study of HHLWG Based on Propensity Score Matched Analysis
- Author
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Weiying Gu, Wei Sang, Yuhao Xue, Yuye Shi, Ziyuan Shen, Dashan Li, Hao Zhang, Taigang Zhu, Chenlu He, Shanlin Nie, Zhenzhen Bian, Mingkang Yao, Yuqing Miao, Shuiping Huang, Ying Wang, and Fei Wang
- Subjects
Oncology ,medicine.medical_specialty ,business.industry ,Proportional hazards model ,Immunology ,diffuse large B-cell lymphoma ,Retrospective cohort study ,propensity score matched ,medicine.disease ,Lymphoma ,prognostic nutrition index ,International Prognostic Index ,Internal medicine ,hemic and lymphatic diseases ,Propensity score matching ,Immunology and Allergy ,Medicine ,prognosis ,Stage (cooking) ,Journal of Inflammation Research ,business ,Diffuse large B-cell lymphoma ,Prognostic Nutritional Index (PNI) ,Original Research - Abstract
Ziyuan Shen,1,* Fei Wang,2,* Chenlu He,1,* Dashan Li,3 Shanlin Nie,3 Zhenzhen Bian,3 Mingkang Yao,4 Yuhao Xue,5 Ying Wang,6 Weiying Gu,2 Taigang Zhu,7 Yuye Shi,5 Hao Zhang,4 Shuiping Huang,1,8 Yuqing Miao,9 Wei Sang3 On behalf of the Huaihai Lymphoma Working Group1Department of Epidemiology and Biostatistics, Xuzhou Medical University, Xuzhou, Jiangsu, Peopleâs Republic of China; 2Department of Hematology, The First Peopleâs Hospital of Changzhou, Changzhou, Jiangsu, Peopleâs Republic of China; 3Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, Peopleâs Republic of China; 4Department of Hematology, Affiliated Hospital of Jining Medical University, Jining, Shandong, Peopleâs Republic of China; 5Department of Hematology, The First Peopleâs Hospital of Huaian, Huaian, Jiangsu, Peopleâs Republic of China; 6Department of Personnel, Suqian First Hospital, Suqian, Jiangsu, Peopleâs Republic of China; 7Department of Hematology, The General Hospital of Wanbei Coal-Electric Group, Suzhou, Peopleâs Republic of China; 8Center for Medical Statistics and Data Analysis, Xuzhou Medical University, Xuzhou, Jiangsu, Peopleâs Republic of China; 9Department of Hematology, Yancheng First Peopleâs Hospital, Yancheng, Jiangsu, Peopleâs Republic of China*These authors contributed equally to this workCorrespondence: Wei SangDepartment of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, Peopleâs Republic of ChinaTel +8613645207648Email xyfylbl515@xzhmu.edu.cnYuqing MiaoDepartment of Hematology, Yancheng First Peopleâs Hospital, Yancheng, Jiangsu, Peopleâs Republic of ChinaTel +8613851342032Email miaomiaomyq@163.comIntroduction: Immunonutritional status is associated with the survival of DLBCL. This multicenter retrospective study aimed to explore the prognostic value of Prognostic Nutrition Index (PNI) in DLBCL patients by using propensity score matched analysis (PSM).Methods: A total of 990 DLBCL cases were recruited from 5 centers of Huaihai Lymphoma Working Group (HHLWG). A 1:1 PSM analysis was performed using the nearest-neighbor method, with a caliper size of 0.02. Cox regression analysis was used to examine factors associated with survival.Results: The median age at diagnosis was 62 years and 52.5% were males, with the 3-y overall survival of 65.1%. According to the MaxStat analysis, 44 was the optimal cut-off point of PNI. After PSM analysis, a total of 282 patients in PNI < 44 group could be propensity matched to PNI ⥠44 patients, creating a group of 564 patients. Multivariable analysis revealed that PNI, age, central nervous system involvement and International Prognostic Index (IPI) were independent prognostic factors for DLBCL. KaplanâMeier analysis indicated that patients with low PNI in Ann Arbor Stage (III/VI), ECOG (< 2), IPI (LR+LIR), GCB, and BCL-2 negative groups had a poor prognosis.Discussion: PNI could accurately stratify the prognosis of DLBCL after PSM analysis.Keywords: diffuse large B-cell lymphoma, prognostic nutrition index, propensity score matched, prognosis
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- 2021
33. Disparity analysis and prognostic value of pretreatment whole blood Epstein-Barr virus DNA load and Epstein-Barr encoding region status in lymphomas: A retrospective multicenter study in Huaihai Lymphoma Working Group
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Ziyuan, Shen, Lingling, Hu, Mingkang, Yao, Chenlu, He, Qinhua, Liu, Fei, Wang, Weiying, Gu, Ying, Wang, Manyu, Dong, Taigang, Zhu, Ting, Yin, Fei, Li, Yingliang, Jin, Shuiping, Huang, Hao, Zhang, and Wei, Sang
- Subjects
Adult ,Aged, 80 and over ,Male ,Epstein-Barr Virus Infections ,Herpesvirus 4, Human ,Middle Aged ,Lymphoma, T-Cell ,Prognosis ,Hodgkin Disease ,Diagnosis, Differential ,Survival Rate ,DNA, Viral ,Humans ,Female ,Lymphoma, Large B-Cell, Diffuse ,Lymphoma, Follicular ,Aged ,Follow-Up Studies ,Retrospective Studies - Abstract
Elevated Epstein-Barr virus (EBV) DNA load is common in lymphomas. However, it remains unclear whether the disparity in viral load and its prognostic value in lymphomas are correlated with Epstein-Barr encoding region (EBER) status. In this retrospective multicenter study, we collected the data of pretreatment whole blood EBV DNA (pre-EBV DNA) and EBER status and evaluated their disparity and prognostic values in lymphomas. A total of 454 lymphoma patients from December 2014 to August 2020 were retrospectively retrieved. Mann-Whitney U test, Kruskal-Wallis test and Bonferroni's adjustment were used to explore the disparity of EBV DNA and EBER status in lymphomas. Time-dependent receiver operating characteristic analysis and MaxStat analysis were used to determine optimal cutoff points of pre-EBV DNA load. Univariable and multivariable Cox proportional hazards models were established for the estimation of prognostic factors. The positive rate of EBV DNA in natural killer T-cell lymphoma (NKTL) patients was higher than that in diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL) and Hodgkin lymphoma (HL) patients, and the median positive pre-EBV copy number of NKTL was also higher than that of FL and DLBCL. EBV DNA could clearly distinguish the prognosis of DLBCL, NKTL, HL and peripheral T-cell lymphoma, and the integration of EBER status and EBV DNA could differentiate the prognosis of HL patients. Multivariable results revealed that pre-EBV DNA load had an effect on the prognosis of NKTL, FL and DLBCL. The status of pre-EBV DNA and EBER were disparate. Whole blood pre-EBV DNA predicted the prognosis of lymphomas, and the combination of EBV and EBER status could differentiate the prognosis of HL.
- Published
- 2021
34. Integrating PDA microtube waveguide system with heterogeneous CHA amplification strategy towards superior sensitive detection of miRNA
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Mengqiao Wang, Shiyan Xiao, Yu Zhu, Xiang Zhou, Yue Yu, Gang Zou, Chenlu He, Xianbao Sun, Haojun Liang, Funing Liu, and Qijin Zhang
- Subjects
education ,Biomedical Engineering ,Biophysics ,Biosensing Techniques ,02 engineering and technology ,01 natural sciences ,Waveguide (optics) ,Displacement reactions ,chemistry.chemical_compound ,Limit of Detection ,parasitic diseases ,microRNA ,Biomarkers, Tumor ,Electrochemistry ,Humans ,Leakage (electronics) ,Chemistry ,010401 analytical chemistry ,Nucleic Acid Hybridization ,DNA ,General Medicine ,Target signal ,Therapeutic evaluation ,021001 nanoscience & nanotechnology ,Polyacetylene Polymer ,0104 chemical sciences ,MicroRNAs ,0210 nano-technology ,Biosensor ,Biotechnology - Abstract
Catalytic hairpin assembly (CHA) is a typical enzyme-free amplification strategy, in which the target can catalyze two hairpin probes to form a duplex and yield multiple outputs signal. However, the non-specific hybridization of two hairpin probes in CHA circuit usually occurred even in the absence of target, causing significant background leakage and impeding its practical applications in trace miRNA analysis. Herein, we proposed a novel heterogeneous CHA (hetero-CHA) design integrating with PDA microtube waveguide system, offering the advantages to enhance the target signal, but suppress the background leakage simultaneously. In hetero-CHA strategy, single-stranded targets are enriched nearby the surface of PDA microtube, facilitating the target-triggered CHA amplification and strand displacement reactions. In contrast, double-stranded DNA complexes formed by uncatalyzed hybridizations are isolated from PDA microtube, impeding the leakage signal. By combination with condensing enrichment effect, the proposed hetero-CHA probe exhibited high selectivity and sensitivity to miRNA target, giving a detection limit as low as 3.3 fM. More importantly, the proposed hetero-CHA probe can be applied directly to distinguish the expression of miRNA-21 in clinical serum of cancer patients (including lung, breast and pancreatic) from those of healthy human beings, favoring the cancer diagnosis and therapeutic evaluation.
- Published
- 2019
35. Chiral induction, modulation and locking in porphyrin based supramolecular assemblies with circularly polarized light
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Gang Zou, Qijin Zhang, Jingang Hu, Yifan Xie, Chenlu He, and Hongli Zhang
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Materials science ,010405 organic chemistry ,Metals and Alloys ,Supramolecular chemistry ,General Chemistry ,010402 general chemistry ,01 natural sciences ,Combinatorial chemistry ,Porphyrin ,Catalysis ,0104 chemical sciences ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,chemistry.chemical_compound ,chemistry ,Modulation ,Materials Chemistry ,Ceramics and Composites ,Circular polarization ,Chiral induction - Abstract
Herein, we propose a novel circularly polarized light (CPL) triggered asymmetric self-assembly strategy to controllably construct chiral supramolecular assemblies from achiral porphyrin derivatives.
- Published
- 2019
36. Electrochemical sensors for hydroquinone and catechol based on nano-flake graphite and activated carbon sensitive materials
- Author
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Xuan Yang, Chenlu He, Weixiang Lin, Yijuan Qiu, Pengfei Li, Yandan Chen, Biao Huang, and Xinyu Zheng
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Mechanics of Materials ,Mechanical Engineering ,Materials Chemistry ,Metals and Alloys ,Condensed Matter Physics ,Electronic, Optical and Magnetic Materials - Published
- 2022
37. Factors associated with stroke among patients with type 2 diabetes mellitus in China: a propensity score matched study
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Wei Wang, Xunbao Zhang, Peian Lou, Ziyuan Shen, Zhongming Sun, Enchun Pan, Qian Chen, and Chenlu He
- Subjects
medicine.medical_specialty ,China ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Type 2 diabetes ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Risk Factors ,Internal medicine ,Diabetes mellitus ,Internal Medicine ,medicine ,Humans ,Family history ,Propensity Score ,Stroke ,business.industry ,General Medicine ,Odds ratio ,medicine.disease ,Diabetes Mellitus, Type 2 ,Propensity score matching ,Underweight ,medicine.symptom ,business ,Dyslipidemia - Abstract
This study aimed to examine the prevalence of stroke and associated factors of stroke in patients with type 2 diabetes(T2DM) in China.Participants were 18,013 T2DM patients recruited with stratified random cluster sampling method from December 2013 to January 2014 in China. Propensity score matching was used to eliminate confounding effects between groups and logistic regression analysis was used to examine factors associated with stroke among T2DM patients.Overall, the prevalence of stroke in the subjects with T2DM was 9.5%. After nearest neighbor matching, smoking (OR = 1.60, 95%CI: 1.26-2.03), hypertension (OR = 2.96, 95%CI: 2.55-3.43), dyslipidemia (OR = 2.00, 95%CI: 1.71-2.33), family history of stroke (OR = 2.02, 95%CI: 1.61-2.54), obesity (OR = 1.21, 95%CI: 1.01-1.45) and sleep duration 6 h/day (OR = 1.44, 95%CI: 1.20-1.73) or 8 h/day (OR = 1.22, 95%CI: 1.05-1.42) were positively associated with stroke, whereas drinking 1-3 days/week (OR = 0.64, 95%CI: 0.45-0.90) or daily (OR = 0.45, 95%CI: 0.33-0.60), effective exercise (OR = 0.65, 95%CI: 0.57-0.73) and underweight (OR = 0.30, 95%CI: 0.13-0.71) were negatively related to stroke. Besides, the risk of stroke increased substantially with accumulation of above seven modified risk factors. The odds ratio values of stroke in patients having ≥ 5 of the above seven risk factors was 14.39 (95% CI: 8.87-23.26).The prevalence of stroke was high among T2DM in China. It is of great significance to strengthen comprehensive management of health-related behaviors including smoking cessation, moderate alcohol consumption, effective exercise, 6-8 h of sleep duration, keeping normal weight and the prevention of hypertension and dyslipidemia to have sustained beneficial effects on improvements of stroke risk factors.
- Published
- 2021
38. Robust Hierarchical Hovering Control of Autonomous Underwater Vehicles via Variable Ballast System
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Chenlu He, Zhengping Feng, and Anyuan Bi
- Subjects
Ballast ,0209 industrial biotechnology ,Computer science ,Mechanical Engineering ,Control (management) ,020101 civil engineering ,Ocean Engineering ,02 engineering and technology ,Stability (probability) ,0201 civil engineering ,Variable (computer science) ,020901 industrial engineering & automation ,Control theory ,Underwater - Abstract
Hovering control of autonomous underwater vehicles (AUVs) via a variable ballast system (VBS) is challenging owing to the difficulty in precisely estimating related hydrodynamic coefficients and vertical disturbance. In this work, a hierarchical control strategy is proposed which comprises an upper layer—the proportional-integral-derivative (PID) type ballast water mass planner generating the desired ballast mass, and a lower layer—the continuous mass flowrate controller adjusting the actual ballast mass. The resulting flowrate algorithm endows the system with local uniform asymptotic stability and robustness to both modeling errors and vertical disturbance. Numerical results verify the feasibility and effectiveness of the proposed hierarchical hovering control strategy.
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- 2020
39. Superrepression through Altered Corepressor–Activated Protein:Protein Interactions
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Dorothy Beckett, Chenlu He, Gregory S. Custer, Silvina Matysiak, and Jingheng Wang
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0301 basic medicine ,Biotin binding ,Protein Conformation ,Operon ,Biotin ,Repressor ,Molecular Dynamics Simulation ,Biochemistry ,Protein–protein interaction ,03 medical and health sciences ,chemistry.chemical_compound ,Allosteric Regulation ,Transcription (biology) ,Escherichia coli ,Carbon-Nitrogen Ligases ,Protein Interaction Maps ,030102 biochemistry & molecular biology ,Escherichia coli Proteins ,Isothermal titration calorimetry ,Cell biology ,Repressor Proteins ,030104 developmental biology ,chemistry ,Thermodynamics ,Protein Multimerization ,Corepressor ,Protein Binding - Abstract
Small molecules regulate transcription in both eukaryotes and prokaryotes by either enhancing or repressing assembly of transcription regulatory complexes. For allosteric transcription repressors, superrepressor mutants can exhibit increased sensitivity to small molecule corepressors. However, because many transcription regulatory complexes assemble in multiple steps, the superrepressor phenotype can reflect changes in any or all of the individual assembly steps. Escherichia coli biotin operon repression complex assembly, which responds to input biotin concentration, occurs via three coupled equilibria, including corepressor binding, holorepressor dimerization, and binding of the dimer to DNA. A genetic screen has yielded superrepressor mutants that repress biotin operon transcription in vivo at biotin concentrations much lower than those required by the wild type repressor. In this work, isothermal titration calorimetry and sedimentation measurements were used to determine the superrepressor biotin binding and homodimerization properties. The results indicate that, although all variants exhibit biotin binding affinities similar to that measured for BirA
- Published
- 2018
40. The ∼170 kyr astronomical cycle in the Early Permian Lucaogou Formation of the Junggar Basin
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Yuyin Li, He Huang, Yuan Gao, Yongqiang Cao, Hu Cheng, Chenlu Hei, and Shuang Liang
- Subjects
cyclostratigraphy ,Milankovitch cycle ,paleoclimate ,organic carbon burial ,Permian ,Lucaogou Formation ,Science - Abstract
According to Milankovitch’s theory, periodic climate change in Earth’s history is controlled by the periodic changes in the Earth’s orbit and axis of rotation. Milankovitch cycle include eccentricity, obliquity, and precession cycles. In addition to them, there are also some amplitude modulation (AM) cycles that affect the climate system through a series of “nonlinear” feedback processes, such as the 173 kyr obliquity AM cycle. Previous studies have demonstrated that the ∼170 kyr cycle modulate the paleoclimate and carbon cycle at mid-high latitude regions in the Meso-Cenozoic. However, due to the limitation of astronomical solutions and the lack of high-resolution geological records, the ∼170 kyr cycle has been less reported in the Paleozoic Era. In this study, cyclostratigraphic analysis of natural gamma ray (GR) logging data from four wells (Ji30, Ji31, Ji32, and Ji174) and total organic carbon (TOC) data from well Ji174 penetrating the Early Permian Lucaogou Formation in Jimusar Sag, Junggar Basin suggests preservation of eccentricity, obliquity, and precession cycles, and the ∼170 kyr AM cycle. Through the astronomical tuning of GR logging data obtained from four wells to eccentricity target cycles, we established the floating astronomical time scale (ATS). The results indicate an average sedimentation rate ranging from 7.4 to 9.5 cm/kyr and a duration from 2.8 to 3.2 million years (Myr) for the Lucaogou Formation. The differences in sedimentation rate and duration among these four wells may result from different well locations. Moreover, the ∼170 kyr cycle signal has been identified in the detrended GR logging and TOC data series, and its obliquity AM series. This signal might be attributed to the obliquity AM cycles originated from the interaction between s3 and s6 (s3 and s6 represent the precession of nodes of Earth and Saturn), which was recorded in the GR logging and TOC data time series due to nonlinear responses within the depositional system.
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- 2024
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41. Chiral induction, transfer and modulation in C3-symmetric columnar liquid crystalline assemblies
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Jingang Hu, Qijin Zhang, Chenlu He, Tianyi Zhu, Gang Zou, and Yan Zhang
- Subjects
Materials science ,Diacetylene ,Supramolecular chemistry ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Photochemistry ,01 natural sciences ,0104 chemical sciences ,chemistry.chemical_compound ,Monomer ,chemistry ,Covalent bond ,Liquid crystal ,Phase (matter) ,Materials Chemistry ,Homochirality ,0210 nano-technology ,Circular polarization - Abstract
Circularly polarized light (CPL), regarded as a true chiral entity, has been suggested as one possible origin of homochirality in nature. It still remains difficult to understand the exact mechanism of chiral induction, transfer and amplification in supramolecular assemblies. Herein, we designed and synthesized three discotic diacetylene LC monomers, in which the peripheral diacetylene flexible chains linked to the triazole derivative cores through H-bonding or covalent bonds. We established links between the primary chemical structures of discotic diacetylene monomers, liquid crystal phase structures and optically active properties in the final supramolecular assemblies. Moreover, the type of junction bonding interaction exhibited a significant influence on the chiral transfer in a supramolecular columnar LC system.
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- 2017
42. Author Correction: Dissymmetry enhancement in enantioselective synthesis of helical polydiacetylene by application of superchiral light
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Yan Kuai, Lin Yang, Gang Zou, Sizhen Shan, Douguo Zhang, Jingang Hu, Guang Yang, Qijin Zhang, and Chenlu He
- Subjects
0301 basic medicine ,Physics ,Multidisciplinary ,Science ,Polymer characterization ,General Physics and Astronomy ,Mistake ,02 engineering and technology ,General Chemistry ,021001 nanoscience & nanotechnology ,Polymerization mechanisms ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,030104 developmental biology ,Quantum mechanics ,lcsh:Q ,Photocatalysis ,lcsh:Science ,0210 nano-technology ,Author Correction - Abstract
Superchiral light, generated by the interference of two counter-propagating circularly polarized light (CPL) with same frequency, opposite handedness and different intensity, exhibits enhanced dissymmetry in its interaction with chiral molecules, and has the potential for ultrasensitive detection and characterization of chiral molecules. It is anticipated that the enhanced optical dissymmetry in superchiral light (SCL) field may be utilized to promote asymmetric photochemical reactions efficiency. Herein we reported SCL impart greater chiral bias to trigger asymmetric photo-polymerization reaction from initially achiral diacetylene (DA) monomer, and the enhanced optical dissymmetry for whole polydiacetylene (PDA) films could be achieved. An explanation based on the chiral transfer and amplification of chiral bias from SCL during the polymerization process has been proposed. Moreover, thus formed chiral PDA films polymerized by SCL exhibited enhanced enantioselective recognition ability, and can serve as a direct visual probe for the discrimination of some specific enantiomers.
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- 2019
43. Enantioselective cytotoxicity of chiral polymer vesicles with linear and hyperbranched structures
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Funing Liu, Junjie Cheng, Jingang Hu, Chenlu He, Hongli Zhang, Qijin Zhang, and Gang Zou
- Subjects
Optical Phenomena ,Linear polymer ,Polymers ,Surface Properties ,Stereoisomerism ,Antineoplastic Agents ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,HeLa ,Humans ,Cytotoxicity ,chemistry.chemical_classification ,biology ,Vesicle ,Enantioselective synthesis ,General Chemistry ,Polymer ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,biology.organism_classification ,0104 chemical sciences ,chemistry ,Biophysics ,0210 nano-technology ,Chirality (chemistry) ,Reactive Oxygen Species ,HeLa Cells - Abstract
Herein, we study the enantioselective cytotoxicity of vesicles self-assembled by optically active linear polymers (LNPs) and hyperbranched polymers (HBPs). Compared to HBP vesicles, LNP vesicles exhibit properties such as a higher surface charge density and more violent interaction with simulated biomembranes which results in larger cytotoxicity against HeLa cells. Specifically, racemic-LNP vesicles exhibit the largest cytotoxicity of all. More interestingly, there is no significant enantioselective dependence of HBP vesicles on the abovementioned properties. Overall, we proved that the cytotoxicity of vesicles is deeply related to chirality and topological-structures. This research is of great fundamental value for the design of novel bio-interface materials.
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- 2019
44. Dissymmetry enhancement in enantioselective synthesis of helical polydiacetylene by application of superchiral light
- Author
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Jingang Hu, Douguo Zhang, Chenlu He, Lin Yang, Qijin Zhang, Yan Kuai, Gang Zou, Guang Yang, and Sizhen Shan
- Subjects
Materials science ,Science ,General Physics and Astronomy ,02 engineering and technology ,010402 general chemistry ,Photochemistry ,01 natural sciences ,Article ,General Biochemistry, Genetics and Molecular Biology ,chemistry.chemical_compound ,lcsh:Science ,Circular polarization ,Multidisciplinary ,Diacetylene ,Enantioselective synthesis ,General Chemistry ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,Visual probe ,Monomer ,chemistry ,Polymerization ,lcsh:Q ,Enantiomer ,0210 nano-technology - Abstract
Superchiral light, generated by the interference of two counter-propagating circularly polarized light (CPL) with same frequency, opposite handedness and different intensity, exhibits enhanced dissymmetry in its interaction with chiral molecules, and has the potential for ultrasensitive detection and characterization of chiral molecules. It is anticipated that the enhanced optical dissymmetry in superchiral light (SCL) field may be utilized to promote asymmetric photochemical reactions efficiency. Herein we reported SCL impart greater chiral bias to trigger asymmetric photo-polymerization reaction from initially achiral diacetylene (DA) monomer, and the enhanced optical dissymmetry for whole polydiacetylene (PDA) films could be achieved. An explanation based on the chiral transfer and amplification of chiral bias from SCL during the polymerization process has been proposed. Moreover, thus formed chiral PDA films polymerized by SCL exhibited enhanced enantioselective recognition ability, and can serve as a direct visual probe for the discrimination of some specific enantiomers., Superchiral light can be utilized to promote asymmetric photochemical reactions. Here the authors show that superchiral light imparts greater chiral bias to trigger asymmetric photo-polymerization reactions from initially achiral diacetylene monomers and enhanced optical dissymmetry in polydiacetylene films.
- Published
- 2018
45. Robust Hierarchical Hovering Control of Autonomous Underwater Vehicles via Variable Ballast System.
- Author
-
Anyuan Bi, Zhengping Feng, and Chenlu He
- Published
- 2021
- Full Text
- View/download PDF
46. Plasticity in Protein Sequence-Function Relationships
- Author
-
Chenlu He and Dorothy Beckett
- Subjects
Protein sequencing ,Biophysics ,Computational biology ,Biology ,Plasticity ,Function (biology) - Published
- 2020
47. Protein:Protein Interactions Control Sensitivity of a Transcription Response to Input Signal
- Author
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Gregory S. Custer, Silvina Matysiak, Chenlu He, Jingheng Wang, and Dorothy Beckett
- Subjects
Transcription (biology) ,Chemistry ,Biophysics ,Protein–protein interaction ,Cell biology - Published
- 2018
48. Superrepression through Altered Corepressor-Activated Protein:Protein Interactions.
- Author
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Chenlu He, Custer, Gregory, Jingheng Wang, Matysiak, Silvina, and Beckett, Dorothy
- Published
- 2018
- Full Text
- View/download PDF
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