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BackgroundBeinaglutide, whose active ingredient is rhGLP-1, has been widely used as a pharmacological therapy for T2DM. We explored the safety and pharmacokinetics of beinaglutide in Chinese overweight/obese volunteers to lay a foundation for clinical applications of beinaglutide as an anti-obesity drug.MethodsAn open-label, single center, multiple ascending dose phase I clinical trial was conducted in 16 overweight/obese Chinese volunteers. The plasma concentrations of beinaglutide were determined by a validated ELISA method and the pharmacokinetic parameters were estimated via non-compartmental analysis methods. Adverse events were also recorded.ResultsBeinaglutide sequentially multiple dosing (three times daily) at different doses were generally well tolerated, without serious AEs leading to discontinuation of the trial. After multiple subcutaneous injections of different doses (0.1, 0.14 and 0.2 mg), the average blood concentration of beinaglutide with or without baseline correction showed a similar trend among different dose groups on different study days. After reaching the peak concentration around 15 min, it began to decrease, and the median of Tmax and Tmax,adj was 10–15 min. The exposure in vivo increased in proportion to the dosage increment, demonstrating linear pharmacokinetic characteristics. There were no statistically significant differences in the main PK parameters and no accumulation of beinaglutide after multiple dosing. After multiple subcutaneous injections, a gender difference was observed, while no differences in BMI were found under the grouping conditions.ConclusionThe safety profile and pharmacokinetic properties support further development and clinical applications of beinaglutide as an anti-obesity drug.Systematic Review Registration[https://register.clinicaltrials.gov/prs/app/action/SelectProtocol?sid=S000BPEI&selectaction=Edit&uid=U00050YQ&ts=2&cx=wy0ioj].

BackgroundLymph node metastasis is the major cause of increased recurrence and death in patients with papillary thyroid carcinoma (PTC). We evaluate the clinicopathologic factors affecting excellent response (ER) in patients with PTC with lymph node metastasis following operation and 131I ablation therapy.MethodsA total of 423 patients with PTC with lymph node metastasis who underwent thyroidectomy and postoperative 131I ablation therapy were enrolled. The relationship between clinicopathological factors affecting ER achievement was analyzed.ResultsMultivariate analysis showed that the foci diameter (≤1 cm), unifocal, combination with Hashimoto’s thyroiditis (HT), lymph node metastases rate (LR) (≤40%), no postoperative lymph node metastasis, low preablative stimulated thyroglobulin (ps-Tg) level (≤3.87 ng/mL), and the time of 131I ablation therapy (one time) were positively correlated with the ER achievement [odds ratio (OR): 1.744, 3.114, 3.920, 4.018, 2.074, 9.767, and 49.491, respectively; all p < 0.05]. The receiver operating characteristic (ROC) curves showed that the cutoff values of ps-Tg and LR were 4.625 ng/mL and 50.50%, respectively. The AUC of ROC of ps-Tg and LR for predicting ER achievement was 0.821 and 0.746, respectively. The Tg and the cumulative risk of non-ER elevated with the increase of LR, especially for the high-level ps-Tg (>4.625 ng/mL) group.ConclusionThe foci diameter and number, combination with HT, LR, and ps-Tg level are independent factors for ER. Ps-Tg level and LR are valid predictive factors for the efficacy of 131I therapy in patients with PTC. The predictive value of the cumulative risk of non-ER can be improved by the combination of ps-Tg and LR.

In this study, a fuzzy logic system to tune the parameters of terminal sliding mode control with a sliding perturbation observer (TSMCSPO) in real-time is proposed according to the system’s state changes to improve the control performance of TSMCSPO for a 5-DOF robot manipulator used for nuclear reactor dismantlement. Accurate trajectory tracking control is required when using a multi-DOF robot manipulator to cut the decommissioned nuclear reactor. A TSMCSPO scheme using TSMC in SPO has been proposed in previous research, which improves the estimation and convergence performance of traditional SMCSPO. In TSMCSPO, the parameters of the controller are important to enhance the control performance. Moreover, due to the influence of the working environment and the uncertainty of the system, the characteristics of the system will be changed during the trajectory tracking control of the multi-degree-of-freedom robot manipulator. Therefore, real-time optimal parameter tuning is required. In this regard, using fuzzy logic to tune the parameters is an effective method. By designing fuzzy rules, the controller parameters can be optimized. In this study, the proposed algorithm and, the trajectory tracking control simulation of the robot manipulator in the nuclear reactor vessel internal (RVI) are implemented in MATLAB/Simulink environment. The control algorithm is verified by the experiments on a real robot manipulator platform. The outstanding control performance of the algorithm is demonstrated by comparing the trajectory tracking error between the proposed fuzzy TSMCSPO scheme and TSMCSPO with fixed parameters.

Abstract Background/purpose Proliferative diabetic retinopathy (PDR) is a major diabetic microvascular complication, characterized by pathological angiogenesis. This study sets out to investigate the potential molecular mechanism in the angiogenesis during PDR. Methods The expression of microRNA-30b (miR-30b) was quantified in a streptozotocin (STZ)-induced mouse model of PDR. The binding affinity between SIRT1 and miR-30b was then identified and validated. After transduction with In-miR-30b or combined with sh-SIRT1, high-glucose (HG)-induced retinal microvascular endothelial cells (RMECs) were co-cultured with extracellular vesicles (EVs) derived from the plasma of PDR mice (plasma-EVs). The proliferation and angiogenesis of RMECs were then detected in vitro. Results miR-30b expression was upregulated in the retinal tissue of PDR mice. SIRT1 was a target gene of miR-30b and under the negative regulation by miR-30b in RMECs. In contrast, inhibition of miR-30b resulted in elevated SIRT1 expression, thus alleviating the angiogenesis of RMECs. miR-30b was enriched in the plasma-EVs and could be delivered to RMECs, in which miR-30b exerted pro-angiogenic effects. Furthermore, inhibition of miR-30b arrested the progression of PDR in mice by promoting the expression of SIRT1. Conclusion Collectively, the present study pinpointed the involvement of miR-30b delivered by plasma-EVs in PDR angiogenesis, thus laying the basis for the development of novel therapeutic targets for the treatment of PDR.

Ultrasonic feedback energy is affected by the variety, planting, and growth state of crops; therefore, it is difficult to find applications for this energy in precision agriculture systems. To this end, an ultrasonic sensor was mounted in a spray boom height detection system. Winter wheat was used as the test object to obtain feedback energy values for the spray boom height from the top of the wheat in the field during six critical growth stages: the standing stage, the jointing stage, the booting stage, the heading stage, the filling stage, and the maturity stage. The relationship between the actual value of the height from the spray boom at the top of the wheat (Habw) and the detected value of the height from the spray boom at the top of the wheat (Hdbw) was analyzed. A spray boom height detection model based on the ultrasonic sensor during the full growth cycle of wheat was determined. Field validation tests showed that the applicability of the spray boom height detection distance (Dd) of the spray boom height detection model proposed in the present study was 450~950 mm. Within the applicable Dd range, the detection error of the detection model was ≤50 mm during the full growth cycle. This study provides a method for constructing a boom height detection model based on the whole growth cycle of wheat, which improves the reliability and accuracy of ultrasonic boom height detection for different wheat growth stages. The proposed method solves the problem of low accuracy of repeated detection of low-cost ultrasonic sensors in different environments and can provide technical support for improving field applications of the boom height control system based on ultrasonic sensors.

Repeated and missed spraying are common problems during the working of boom sprayers, especially in the breakpoint continuous process. Therefore, the present study investigated a breakpoint continuous spraying system for automatic-guidance boom sprayers based on a hysteresis compensation algorithm for spraying. An operational breakpoint identification algorithm, which combines a real-time kinematic global navigation satellite system (RTK-GNSS) and wheel odometer, was proposed; a pre-adjusted proportional-integral-derivative (PID) control algorithm for the opening degree of the proportional control valve was designed in thus study. Tests were conducted to establish equations correlating the opening degree of the proportional control valve, pump output flow rate, and main pipeline flow rate, with an R2 ≥ 0.9525. The time to adjust to the target flow rate was experimentally tested. The breakpoint identification accuracy of the RTK-GNSS and RTK-GNSS + wheel odometer was experimentally assessed. A field spraying deposition variation experiment was conducted. According to the results, the system effectively eliminated missed spraying, with a maximum repeated spraying distance of ≤3.3 m, and it achieved a flow control error within 3%. This system also reduced the repeated spraying area and enhanced the pesticide spraying quality of breakpoint continuous spraying for automatic-guidance boom sprayers.

This paper presents a robust force/torque-based impedance control with a perturbation observer, particularly for high payload systems. One of the special cases of such systems is an assistive robot for paraplegics (ARP) with a sit-stand mechanism (STSM) and, therefore, its control is investigated for enhanced efficiency and safety. Recently, a nonlinear robust position control known as sliding mode control with sliding perturbation observer (SMCSPO) was implemented on STSM and proven its effectiveness. However, with increasing subject body mass (payload), high switching control gains are required which consequently either result in increased tracking error or chattering in control performance. In this regard, a new framework of integrated control was proposed which combines the feature of impedance control with estimated information from SMCSPO resulting in an enhanced control algorithm. The advantage of this impedance control is that because of SMCSPO, it utilizes the linear system information with position feedback only to estimate the states and perturbation (nonlinearities, uncertainties, and disturbance). This estimated perturbation then helps in compensating the actual perturbation effect from the system response. Moreover, the impedance control excludes the saturation function which helps prevent the chattering with low control gains. The simulation and experiment results validated that the proposed algorithm shows better transient response with minimized estimation error and reduced chattering effect than SMCSPO.

Abstract Background Recaticimab (SHR-1209, a humanized monoclonal antibody against PCSK9) showed robust LDL-C reduction in healthy volunteers. This study aimed to further assess the efficacy and safety of recaticimab in patients with hypercholesterolemia. Methods In this randomized, double-blind, placebo-controlled phase 1b/2 trial, patients receiving stable dose of atorvastatin with an LDL-C level of 2.6 mmol/L or higher were randomized in a ratio of 5:1 to subcutaneous injections of recaticimab or placebo at different doses and schedules. Patients were recruited in the order of 75 mg every 4 weeks (75Q4W), 150Q8W, 300Q12W, 150Q4W, 300Q8W, and 450Q12W. The primary endpoint was percentage change in LDL-C from the baseline to end of treatment (i.e., at week 16 for Q4W and Q8W schedule and at week 24 for Q12W schedule). Results A total of 91 patients were enrolled and received recaticimab and 19 received placebo. The dose of background atorvastatin in all 110 patients was 10 or 20 mg/day. The main baseline LDL-C ranged from 3.360 to 3.759 mmol/L. The least-squares mean percentage reductions in LDL-C from baseline to end of treatment relative to placebo for recaticimab groups at different doses and schedules ranged from −48.37 to −59.51%. No serious treatment-emergent adverse events (TEAEs) occurred. The most common TEAEs included upper respiratory tract infection, increased alanine aminotransferase, increased blood glucose, and increased gamma-glutamyltransferase. Conclusion Recaticimab as add-on to moderate-intensity statin therapy significantly and substantially reduced the LDL-C level with an infrequent administration schedule (even given once every 12 weeks), compared with placebo. Trial registration ClinicalTrials.gov , number NCT03944109

The anti-Compton phoswich (ACP) detector, which is composed of multiple scintillators with one photomultiplier tube, takes into account the Compton suppression function and portability, and therefore, a discussion on how to design its shape to improve the performance of the detector has become necessary. Based on an ACP detector using a well-typed LaBr3:Ce/NaI:Tl composite scintillator that has been developed in the laboratory in early work, this study uses GEANT4 to simulate and study the influence of the change in the shape and size of the secondary scintillator on the performance of the detector, such as the Compton suppression ratio, the energy resolution, and the full-energy peak (FEP) loss. In the course of the study, we mainly investigate the variation of the performance of the detector in two ways. First, the inclination angle of the truncated cone is gradually changed to compare its FEP address and Compton suppression ratio. Second, the case of the well-shaped and annular-shaped secondary scintillators is compared, respectively, to find out their impact on energy resolution and FEP address. The final results show that, compared with the ACP detector using a φ75 × 90 mm2 LaBr3:Ce/NaI:Tl cylindrical composite scintillator, a truncated cone-shaped composite scintillator of 0.8 inclination may have an equivalent 137% light yield (137% signal-to-noise ratio), a Compton suppression ratio of 89.62% (at 662 keV), 89.98% FWHM energy resolution, and a volume reduction of 36.74%, which means that the weight of the detector is reduced by 2.107 kg.

Developing a ceramic scintillator operating in a phoswich detector is a feasible way for pulse shape discrimination. A YAG:Ce transparent ceramic scintillator has been synthesized by using the vacuum sintering method. In this work, we present a new phoswich detector mainly developed for the determination of low radioactivity levels. The system was constructed by combining a transparent ceramic scintillator, for the detection of α particles, and a CsI:Tl crystal, for the detection of γ-rays. With the device proposed here, the particle identification in a mixed α–γ field has been achieved with the rise time discrimination method. Furthermore, the figure of merit can also be improved using the phoswich detector. The higher reliability, simplicity, and low cost of the design that combines ceramics and crystals make the YAG ceramic have extremely good application prospects.

Abstract The charge phenomena under sine and half‐wave sine voltages within the frequency range of 500 Hz are studied here. Based on the pulsed electro‐acoustic method, the traditional circuit design under high‐frequency voltages is first analysed. It is found that the selection of a 186 pF protection capacitor and a 333 kΩ protection resistor can ensure that the actual voltage applied to the sample is consistent with the expected input. Based on this design, experimental results show that the polarity of the charge accumulated in the depth of the sample is determined by that of the upper electrode. Comparison results under special voltages with different amplitudes and frequencies indicate that the amount of accumulated charge under sine voltages are larger than those under positive and negative half‐wave sine and DC conditions, and the samples under lower‐frequency conditions show more charge accumulation. The maximum electric field strengths appear at 90 and 270 degrees of the sine voltage with a frequency of 10 Hz, and their values are 68.55 and 81.82 kV/mm, respectively. Therefore, the charge characteristics are easily affected by the voltage’s waveform and frequency parameters. The results obtained here can provide guidance for the application of insulating materials under special voltage environments.

This paper examined the impact of the isotope effect on the lattice structure of monocrystalline silicon, as well as the defects caused by proton irradiation. First, by using the molecular dynamics simulation, the number of point defects of monocrystalline silicon exposed to protons was calculated, and the number of stable defects in 30Si was 11%–14% lower than that in 28Si. Second, the structures of various isotopes at 300 K were simulated through ab initio molecular dynamics simulations based on the density functional theory. In addition, the thermal stability of the two structures was determined. The results indicated that pure 30Si had superior radiation resistance to pure 28Si, which suggested a new idea for the radiation resistance enhancement of silicon materials.

Abstract Aims/Introduction Non‐alcoholic fatty liver disease (NAFLD) is becoming more and more prevalent in type 2 diabetes mellitus. Evidence connecting NAFLD to diabetic retinopathy (DR) is increasing, but the results vary. Thus, we undertook a meta‐analysis to explore the effect of NAFLD on diabetic retinopathy in patients with type 2 diabetes mellitus. Materials and Methods PubMed, Embase, Cochrane and Scopus database were searched for until September 30, 2019. Original studies analyzing the association between NAFLD and diabetic retinopathy in the type 2 diabetic population were included. This meta‐analysis was processed by RevMan 5.3 software. Subgroup analyses based on countries were carried out. The pooled odds ratios and 95% confidence intervals were used to evaluate the association between NAFLD and diabetic retinopathy incidence. The I2 test was used to assess heterogeneity of studies. Results We retrieved 414 articles, and nine studies involving 7,170 patients were included in the final analysis. The pooled effects estimate suggested that NAFLD was not associated with the risk of diabetic retinopathy in patients with type 2 diabetes mellitus. Subgroup analysis suggested that in China, Korea and Iran, patients with type 2 diabetes mellitus with NAFLD had a decreased risk for diabetic retinopathy compared with the non‐NAFLD individuals. However, in Italy and India, patients with type 2 diabetes mellitus with NAFLD had an increased risk for diabetic retinopathy compared with the non‐NAFLD individuals. In addition, no relevance between NAFLD and diabetic retinopathy was found in America. Conclusions On the whole, there was no association between NAFLD and diabetic retinopathy in individuals with type 2 diabetes mellitus. However, subgroup analysis showed that a difference of country may have an influence on the result.

The free-piston engine is a type of none-crank engine that could be operated under variable compression ratio, and this provides it flexible fuel applicability and low engine emission potential. In this work, several 1-D engine models, including conventional gasoline engines, free-piston gasoline engines and free-piston hydrogen engines, have been established. Both engine performance and emission performance under engine speeds between 5–11 Hz and with different equivalent ratios have been simulated and compared. Results indicated that the free-piston engine has remarkable potential for NOx reduction, and the largest reduction is 57.37% at 6 Hz compared with a conventional gasoline engine. However, the figure of NOx from the hydrogen free-piston engine is slightly higher than that of the gasoline free-piston engine, and the difference increases with the increase of engine speed. In addition, several factors and their relationships related to hydrogen combustion in the free-piston engine have been investigated, and results show that the equivalent ratio φ=0.88 is a vital point that affects NOx production, and the ignition advance timing could also affect combustion duration, the highest in-cylinder temperature and NOx production to a large extent.

ObjectiveTo explore the influencing factors and cumulative risk of lymph node metastasis (LNM) in papillary thyroid microcarcinoma (PTMC) patients.Methods607 patients confirmed PTMC pathologically after thyroidectomy were enrolled in this retrospective study. The rate of LNM was calculated. Different clinicopathological characteristics were compared in PTMC patients with and without LNM and in different subgroups of LNM, respectively. Correlation between clinicopathological characteristics and LNM was analyzed and the cumulative risk of LNM according to different clinicopathological characteristics was calculated.Results(1) There were 228 cases (37.56%) of PTMC combined with LNM. Compared with the non-lymph node metastasis group, the proportion of age 0.5cm, extracapsular invasion, HT and intermediate-to-high risk stratification for recurrence of the LNM group was significantly increased (all p0.5cm,HT were independently positively correlated with LNM (all p 5 and the positive rate of LN were both higher in male group than that in the female group. The proportion of multiple foci and HT in LLNM group was higher than that in CLNM group (all P0.5cm and HT were independent risk factors of LNM; HT was an independent risk factor for LNM in female

Engineering designs for mountainous highways emphasize compliance checking to ensure safety. However, relying solely on compliance checking may lead designers to minimize costs at the expense of high risk indicators, since the overall risk level of the highway design is unknown to the designers. This paper describes a method for the simultaneous consideration of traffic safety risks and the associated cost burden related to the appropriate planning and design of a mountainous highway. The method can be carried out in four steps: First, the highway design is represented by a new parametric framework to extract the key design variables that affect not only the life-cycle cost but also the operational safety. Second, the relationship between the life-cycle cost and the operational safety risk factors is established in the cost-estimation functions. Third, a fault tree analysis (FTA) is introduced to identify the traffic risk factors from the design variables. The safety performance of the design solutions is also assessed by the generalized linear-regression model. Fourth, a theory of acceptable risk analysis is introduced to the traffic safety assessment, and a computing algorithm is proposed to solve for a cost-efficient optimal solution within the range of acceptable risk, in order to help decision-makers. This approach was applied and examined in the Sichuan–Tibet Highway engineering project, which is located in a complex area with a large elevation gradient and a wide range of mountains. The experimental results show that the proposed approach significantly improved both the safety and cost performance of the project in the study area. Keywords: Highway planning and design, Cost–safety optimization, Acceptable risk assessment, Sichuan–Tibet Highway

Sleep–wake disruptions are among the most prevalent and burdensome non-motor symptoms of Parkinson’s disease (PD). Clinical studies have demonstrated that these disturbances can precede the onset of typical motor symptoms by years, indicating that they may play a primary function in the pathogenesis of PD. Animal studies suggest that sleep facilitates the removal of metabolic wastes through the glymphatic system via convective flow from the periarterial space to the perivenous space, upregulates antioxidative defenses, and promotes the maintenance of neuronal protein homeostasis. Therefore, disruptions to the sleep–wake cycle have been associated with inefficient metabolic clearance and increased oxidative stress in the central nervous system (CNS). This leads to excessive accumulation of alpha-synuclein and the induction of neuronal loss, both of which have been proposed to be contributing factors to the pathogenesis and progression of PD. Additionally, recent studies have suggested that PD-related pathophysiological alterations during the prodromal phase disrupt sleep and circadian rhythms. Taken together, these findings indicate potential mechanistic interactions between sleep–wake disorders and PD progression as proposed in this review. Further research into the hypothetical mechanisms underlying these interactions would be valuable, as positive findings may provide promising insights into novel therapeutic interventions for PD.

Zonisamide has been used as an add-on treatment in order to overcome the deficiencies of the general therapies currently used to resolve the motor complications and non-motor symptoms of Parkinson disease. Various trials have been designed to investigate the mechanism of action and treatment effects of zonisamide in this condition. Most clinical trials of zonisamide in Parkinson disease were from Japan. The vast majority of studies used changes in the Unified Parkinson’s Disease Rating Scale (UPDRS) scores and daily “OFF” time as primary endpoints. Based on adequate randomized controlled trials, zonisamide is considered a safe and efficacious add-on treatment in Parkinson disease. The most convincing proof is available for a dosage of 25–50 mg, which was shown to lead to a significant reduction in the UPDRS III score and daily “OFF” time, without increasing disabling dyskinesia. Furthermore, zonisamide may play a beneficial role in improving non-motor symptoms in PD, including impulsive–compulsive disorder, rapid eye movement sleep behavior disorder, and dementia. Among the various mechanisms reported, inhibition of monoamine oxidase-B, blocking of T-type calcium channels, modulation of the levodopa–dopamine metabolism, modulation of receptor expression, and neuroprotection are the most often cited. The mechanisms underlying neuroprotection, including modulation of dopamine turnover, induction of neurotrophic factor expression, inhibition of oxidative stress and apoptosis, inhibition of neuroinflammation, modulation of synaptic transmission, and modulation of gene expression, have been most extensively studied. This review focuses on structure, pharmacokinetics, mechanisms, therapeutic effectiveness, and safety and tolerability of zonisamide in patients with Parkinson disease.

The long-life, high yield deuterium-deuterium (D-D) neutron tube has become one of the research hotspots. Here, deuterated polyethylene target, heavy water target and titanium target were investigated by Stopping and Range of Ions in Matter (SRIM). The calculation showed that the deuterated polyethylene target, which was a potential target material, had the highest yield at an incident energy of 120 keV. Further, considering the unfavorable factors such as impurity ions and high temperature, the coating was used to protect the target material. Diamond, boron carbide, boron nitride, silicon carbide, and aluminum carbide were selected. The simulation results showed that the diamond composite deuterated polyethylene film had the best sputtering resistance, and the aluminum nitride composite heavy water target film had the lowest sputtering yield. The two coating materials shield the target, reduced the energy loss of incident ions, and provided a new method for the research of high yield and long life neutron tube.

Limonin (LIM), a furan-containing limonoid, is one of the most abundant components of Dictamnus dasycarpus Turcz. Recent studies demonstrated that LIM has great potential for inhibiting the activity of drug-metabolizing enzymes. However, the mechanisms of LIM-induced enzyme inactivation processes remain unexplored. The main objective of this study was to identify the reactive metabolites of LIM using liquid chromatography-mass spectrometry. Three nucleophiles, glutathione (GSH), N-acetyl cysteine (NAC), and N-acetyl lysine (NAL), were used to trap the reactive metabolites of LIM in in vitro and in vivo models. Two different types of mass spectrometry, a hybrid quadrupole time-of-flight (Q-TOF) mass spectrometry and a LTQ velos Pro ion trap mass spectrometry, were employed to acquire structural information of nucleophile adducts of LIM. In total, six nucleophile adducts of LIM (M1–M6) with their isomers were identified; among them, M1 was a GSH and NAL conjugate of LIM, M2–M4 were glutathione adducts of LIM, M5 was a NAC and NAL conjugate of LIM, and M6 was a NAC adduct of LIM. Additionally, CYP3A4 was found to be the key enzyme responsible for the bioactivation of limonin. This metabolism study largely facilitates the understanding of mechanisms of limonin-induced enzyme inactivation processes.

Background: Lymph node metastasis is the major cause of increased recurrence and death in patients with papillary thyroid carcinoma (PTC). We evaluate the clinicopathologic factors affecting excellent response (ER) in patients with PTC with lymph node metastasis following operation and 131I ablation therapy. Methods: A total of 423 patients with PTC with lymph node metastasis who underwent thyroidectomy and postoperative 131I ablation therapy were enrolled. The relationship between clinicopathological factors affecting ER achievement was analyzed. Results: Multivariate analysis showed that the foci diameter (=1 cm), unifocal, combination with Hashimoto's thyroiditis (HT), lymph node metastases rate (LR) (=40%), no postoperative lymph node metastasis, low preablative stimulated thyroglobulin (ps-Tg) level (=3.87 ng/mL), and the time of 131I ablation therapy (one time) were positively correlated with the ER achievement [odds ratio (OR): 1.744, 3.114, 3.920, 4.018, 2.074, 9.767, and 49.491, respectively; all p < 0.05]. The receiver operating characteristic (ROC) curves showed that the cutoff values of ps-Tg and LR were 4.625 ng/mL and 50.50%, respectively. The AUC of ROC of ps-Tg and LR for predicting ER achievement was 0.821 and 0.746, respectively. The Tg and the cumulative risk of non-ER elevated with the increase of LR, especially for the high-level ps-Tg (>4.625 ng/mL) group. Conclusion: The foci diameter and number, combination with HT, LR, and ps-Tg level are independent factors for ER. Ps-Tg level and LR are valid predictive factors for the efficacy of 131I therapy in patients with PTC. The predictive value of the cumulative risk of non-ER can be improved by the combination of ps-Tg and LR. [ABSTRACT FROM AUTHOR]