150 results on '"Cheng-Pei Lin"'
Search Results
2. Communication in Cancer Care in Asia: A Narrative Review
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Masanori Mori, Cheng-Pei Lin, Shao-Yi Cheng, Sang-Yeon Suh, Sayaka Takenouchi, Raymond Ng, Helen Chan, Sun-Hyun Kim, Ping-Jen Chen, Kwok Keung Yuen, Maiko Fujimori, Takashi Yamaguchi, Jun Hamano, Yoshiyuki Kizawa, Tatsuya Morita, and Diah Martina
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Published
- 2023
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3. MedGlasses: A Wearable Smart-Glasses-Based Drug Pill Recognition System Using Deep Learning for Visually Impaired Chronic Patients
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Wan-Jung Chang, Liang-Bi Chen, Chia-Hao Hsu, Jheng-Hao Chen, Tzu-Chin Yang, and Cheng-Pei Lin
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Artificial intelligence over the Internet of Things (AIoT) ,deep learning ,drug pill recognition ,image sensor ,image processing ,medication-use safety ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
Today, with the arrival of an aging society, the average age of the population is rising. It is known that the physiology of a person degrades with age. There are approximately 285 million visually impaired people in the world, of whom 140 million are elderly people over the age of 50, and 110 million of these visually impaired elderly people suffer from multiple chronic diseases. In the case of multiple medication usage, these 110 million vulnerable people will be more likely to take the wrong medicines or forget to take their medication. To solve this problem, this paper proposes a wearable smart-glasses-based drug pill recognition system using deep learning, named MedGlasses, for visually impaired people to improve their medication-use safety. The proposed MedGlasses system consists of a pair of wearable smart glasses, an artificial intelligence (AI)-based intelligent drug pill recognition box, a mobile device app, and a cloud-based information management platform. Experimental results show that a recognition accuracy of up to 95.1% can be achieved. Therefore, the proposed MedGlasses system can effectively mitigate the problem of drug interactions caused by taking incorrect drugs, thereby reducing the cost of medical treatment and providing visually impaired chronic patients with a safe medication environment.
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- 2020
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4. A Deep Learning-Based Intelligent Medicine Recognition System for Chronic Patients
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Wan-Jung Chang, Liang-Bi Chen, Chia-Hao Hsu, Cheng-Pei Lin, and Tzu-Chin Yang
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Artificial intelligence over the Internet of Things (AIoT) ,chronic diseases ,deep learning ,Internet of Things (IoT) ,medicine recognition ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
This paper proposes an intelligent medicine recognition system based on deep learning techniques, named ST-Med-Box. The proposed system can assist chronic patients in taking multiple medications correctly and avoiding in taking the wrong medications, which may cause drug interactions, and can provide other medication-related functionalities such as reminders to take medications on time, medication information, and chronic patient information management. The proposed system consists of an intelligent medicine recognition device, an app running on an Android-based mobile device, a deep learning training server, and a cloud-based management platform. Currently, eight different medicines can be recognized by the proposed system. The experimental results show that the recognition accuracy reaches 96.6%. Therefore, the proposed system can effectively reduce the problem of drug interactions caused by taking incorrect drugs, thereby reducing the cost of medical treatment and giving patients with chronic diseases a safe medication environment.
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- 2019
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5. Advance Care Planning for Older People with Cancer and Its Implications in Asia: Highlighting the Mental Capacity and Relational Autonomy
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Cheng-Pei Lin, Shao-Yi Cheng, and Ping-Jen Chen
- Subjects
ageing ,cancer ,advance care planning ,mental capacity ,relational autonomy ,Geriatrics ,RC952-954.6 - Abstract
With dramatically increasing proportions of older people, global ageing has remarkably influenced healthcare services and policy making worldwide. Older people represent the majority of patients with cancer, leading to the increasing demand of healthcare due to more comorbidities and inherent frailty. The preference of older people with cancer are often ignored, and they are considered incapable of making choices for themselves, particularly medical decisions. This might impede the provision of their preferred care and lead to poor healthcare outcomes. Advance care planning (ACP) is considered an effective intervention to assist older people to think ahead and make a choice in accordance with their wishes when they possess capacity to do so. The implementation of ACP can potentially lead to positive impact for patients and families. However, the assessment of mental capacity among older adults with cancer might be a crucial concern when implementing ACP, as loss of mental capacity occurs frequently during disease deterioration and functional decline. This article aims to answer the following questions by exploring the existing evidence. How does ACP develop for older people with cancer? How can we measure mental capacity and what kind of principles for assessment we should apply? What are the facilitators and barriers when implementing an ACP in this population? Furthermore, a discussion about cultural adaptation and relevant legislation in Asia is elucidated for better understanding about its cultural appropriateness and the implications. Finally, recommendations in relation to early intervention with routine monitoring and examination of capacity assessment in clinical practice when delivering ACP, reconciling patient autonomy and family values by applying the concept of relational autonomy, and a corresponding legislation and public education should be in place in Asia. More research on ACP and capacity assessment in different cultural contexts and policy frameworks is highlighted as crucial factors for successful implementation of ACP.
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- 2018
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6. A robust TDP-43 knock-in mouse model of ALS
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Huang, Shih-Ling, Wu, Lien-Szu, Lee, Min, Chang, Chin-Wen, Cheng, Wei-Cheng, Fang, Yu-Sheng, Chen, Yun-Ru, Cheng, Pei-Lin, and Shen, Che-Kun James
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Biological Sciences ,Biomedical and Clinical Sciences ,Neurosciences ,Genetics ,Rare Diseases ,Stem Cell Research ,Brain Disorders ,Neurodegenerative ,ALS ,2.1 Biological and endogenous factors ,Aetiology ,Neurological ,Amyotrophic Lateral Sclerosis ,Animals ,Autophagy ,Cell Line ,DNA-Binding Proteins ,Disease Models ,Animal ,Embryonic Stem Cells ,Female ,Gene Knock-In Techniques ,Male ,Mice ,Transgenic ,Motor Neurons ,Muscle ,Skeletal ,Protein Aggregation ,Pathological ,Spinal Cord ,ALS-TDP pathogenesis ,Amyotrophic lateral sclerosis ,Autonomous spinal cord motor neuron degeneration ,Homologous knock-in mouse models with ALS-associated TDP-43 mutations ,Mis-splicing of Bcl-2 pre-mRNA ,TAR DNA-binding protein 43 ,Biochemistry and Cell Biology ,Clinical Sciences ,Biochemistry and cell biology - Abstract
Amyotrophic lateral sclerosis (ALS) is a fatal, adult-onset degenerative disorder of motor neurons. The diseased spinal cord motor neurons of more than 95% of amyotrophic lateral sclerosis (ALS) patients are characterized by the mis-metabolism of the RNA/DNA-binding protein TDP-43 (ALS-TDP), in particular, the presence of cytosolic aggregates of the protein. Most available mouse models for the basic or translational studies of ALS-TDP are based on transgenic overexpression of the TDP-43 protein. Here, we report the generation and characterization of mouse lines bearing homologous knock-in of fALS-associated mutation A315T and sALS-associated mutation N390D, respectively. Remarkably, the heterozygous TDP-43 (N390D/+) mice but not those heterozygous for the TDP-43 (A315T/+) mice develop a full spectrum of ALS-TDP-like pathologies at the molecular, cellular and behavioral levels. Comparative analysis of the mutant mice and spinal cord motor neurons (MN) derived from their embryonic stem (ES) cells demonstrates that different ALS-associated TDP-43 mutations possess critical ALS-causing capabilities and pathogenic pathways, likely modified by their genetic background and the environmental factors. Mechanistically, we identify aberrant RNA splicing of spinal cord Bcl-2 pre-mRNA and consequent increase of a negative regulator of autophagy, Bcl-2, which correlate with and are caused by a progressive increase of TDP-43, one of the early events associated with ALS-TDP pathogenesis, in the spinal cord of TDP-43 (N390D/+) mice and spinal cord MN derived from their ES cells. The TDP-43 (N390D/+) knock-in mice appear to be an ideal rodent model for basic as well as translational studies of ALS- TDP.
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- 2020
7. DNA tension assays reveal that force-dependent integrin activation regulates neurite outgrowth in primary cortical neurons
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Chen, Ying-Chi, Li, Ying, Yan, Ching-Cher Sanders, Hsu, Chao-Ping, Cheng, Pei-Lin, and Tu, Hsiung-Lin
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- 2023
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8. Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery.
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Chang, Ting-Ya, Chen, Chen, Lee, Min, Chang, Ya-Chu, Lu, Chi-Huan, Lu, Shao-Tzu, Wang, De-Yao, Wang, Aijun, Guo, Chin-Lin, and Cheng, Pei-Lin
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Neurons ,Cells ,Cultured ,Animals ,Rats ,rac1 GTP-Binding Protein ,Cell Adhesion ,Endocytosis ,Paxillin ,Hydrogel ,Polyethylene Glycol Dimethacrylate ,bistable switch ,cell biology ,endocytosis ,neurite initiation ,neuroscience ,none ,paxillin ,substrate elasticity ,Cells ,Cultured ,Hydrogel ,Polyethylene Glycol Dimethacrylate ,Biochemistry and Cell Biology - Abstract
Neurite initiation is the first step in neuronal development and occurs spontaneously in soft tissue environments. Although the mechanisms regulating the morphology of migratory cells on rigid substrates in cell culture are widely known, how soft environments modulate neurite initiation remains elusive. Using hydrogel cultures, pharmacologic inhibition, and genetic approaches, we reveal that paxillin-linked endocytosis and adhesion are components of a bistable switch controlling neurite initiation in a substrate modulus-dependent manner. On soft substrates, most paxillin binds to endocytic factors and facilitates vesicle invagination, elevating neuritogenic Rac1 activity and expression of genes encoding the endocytic machinery. By contrast, on rigid substrates, cells develop extensive adhesions, increase RhoA activity and sequester paxillin from the endocytic machinery, thereby delaying neurite initiation. Our results highlight paxillin as a core molecule in substrate modulus-controlled morphogenesis and define a mechanism whereby neuronal cells respond to environments exhibiting varying mechanical properties.
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- 2017
9. The Future of Nursing Education: Necessary Elements and Implementation Strategies for Learning Artificial Intelligence.
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Cheng-Pei LIN, Yu-Chi CHEN, and Lu-Yen Anny CHEN
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HUMAN services programs ,MEDICAL quality control ,ARTIFICIAL intelligence ,NURSING education ,DECISION making ,NURSING ,MACHINE learning - Abstract
As populations age, average life expectancy increases and the complexity of diseases rises, leading to nursing care and healthcare systems facing severe challenges related to inadequate resources. Artificial intelligence (AI), including elements such as investigation, integration, learning, prediction, and decision-making, holds significant potential for application in clinical care not only to enhance care quality but also to help guide the future direction of healthcare. AI applications are already being increasingly utilized to improve the quality of clinical care and to streamline workflows. However, because nursing education has lagged behind in terms of adopting AI, greater attention must be given to training up nursing students with AI-related knowledge and application skills. AI technologies should be integrated into nursing curricula and clinical internships to adapt to the rapidly changing high-tech healthcare environment, enabling the more-effective use of AI technology in providing high-quality and safe nursing care. [ABSTRACT FROM AUTHOR]
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- 2024
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10. Palliative Care for Adult Patients Undergoing Hemodialysis in Asia: Challenges and Opportunities.
- Author
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Wei-Min Chu, Hung-Bin Tsai, Yu-Chi Chen, Kuan-Yu Hung, Shao-Yi Cheng, and Cheng-Pei Lin
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HEMODIALYSIS patients ,HOLISTIC medicine ,ANEMIA ,PALLIATIVE treatment ,CRITICALLY ill ,PATIENTS ,INTERPROFESSIONAL relations ,HEMODIALYSIS ,DECISION making ,AGE distribution ,SYMPTOM burden ,PATIENT-centered care ,WORLD health ,QUALITY of life ,PSYCHOSOCIAL factors ,COGNITIVE aging ,COMORBIDITY ,ADULTS - Abstract
This article underscores the importance of integrating comprehensive palliative care for noncancer patients who are undergoing hemodialysis, with an emphasis on the aging populations in Asian nations such as Taiwan, Japan, the Republic of Korea, and China. As the global demographic landscape shifts towards an aging society and healthcare continues to advance, a marked increase has been observed in patients undergoing hemodialysis who require palliative care. This necessitates an immediate paradigm shift to incorporate this care, addressing the intricate physical, psychosocial, and spiritual challenges faced by these individuals and their families. Numerous challenges impede the provision of effective palliative care, including difficulties in prognosis, delayed referrals, cultural misconceptions, lack of clinician confidence, and insufficient collaboration among healthcare professionals. The article proposes potential solutions, such as targeted training for clinicians, the use of telemedicine to facilitate shared decision-making, and the introduction of time-limited trials for dialysis to overcome these obstacles. The integration of palliative care into routine renal treatment and the promotion of transparent communication among healthcare professionals represent key strategies to enhance the quality of life and end-of-life care for people on hemodialysis. By embracing innovative strategies and fostering collaboration, healthcare providers can deliver more patient-centered, holistic care that meets the complex needs of seriously ill patients within an aging population undergoing hemodialysis. [ABSTRACT FROM AUTHOR]
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- 2024
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11. How is community based ‘out-of-hours’ care provided to patients with advanced illness near the end of life: A systematic review of care provision
- Author
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Alice M Firth, Cheng-Pei Lin, Deok Hee Yi, Joanna Goodrich, Inez Gaczkowska, Frances Waite, Richard Harding, Fliss EM Murtagh, and Catherine J Evans
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Anesthesiology and Pain Medicine ,General Medicine - Abstract
Background: Deaths in the community are increasing. However, community palliative care out-of-hours is variable. We lack detailed understanding of how care is provided out-of-hours and the associated outcomes. Aim: To review systematically the components, outcomes and economic evaluation of community-based ‘out-of-hours’ care for patients near the end of life and their families. Design: Mixed method systematic narrative review. Narrative synthesis, development and application of a typology to categorise out-of-hours provision. Qualitative data were synthesised thematically and integrated at the level of interpretation and reporting. Data sources: Systematic review searching; MEDLINE, EMBASE, PsycINFO, CINAHL from January 1990 to 1st August 2022. Results: About 64 publications from 54 studies were synthesised (from 9259 retrieved). Two main themes were identified: (1) importance of being known to a service and (2) high-quality coordination of care. A typology of out-of-hours service provision was constructed using three overarching dimensions (service times, focus of team delivering the care and type of care delivered) resulting in 15 categories of care. Only nine papers were randomised control trials or controlled cohorts reporting outcomes. Evidence on effectiveness was apparent for providing 24/7 specialist palliative care with both hands-on clinical care and advisory care. Only nine publications reported economic evaluation. Conclusions: The typological framework allows models of out-of-hours care to be systematically defined and compared. We highlight the models of out-of-hours care which are linked with improvement of patient outcomes. There is a need for effectiveness and cost effectiveness studies which define and categorise out-of-hours care to allow thorough evaluation of services.
- Published
- 2023
12. Clonally related visual cortical neurons show similar stimulus feature selectivity
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Li, Ye, Lu, Hui, Cheng, Pei-lin, Ge, Shaoyu, Xu, Huatai, Shi, Song-Hai, and Dan, Yang
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Stem Cell Research - Nonembryonic - Non-Human ,Neurosciences ,Eye Disease and Disorders of Vision ,Stem Cell Research ,Underpinning research ,1.1 Normal biological development and functioning ,Neurological ,Animals ,Animals ,Newborn ,Carbenoxolone ,Cell Communication ,Clone Cells ,Connexin 26 ,Connexins ,Female ,Gap Junctions ,Male ,Mice ,Mice ,Inbred C57BL ,Models ,Neurological ,Neurons ,Visual Cortex ,General Science & Technology - Abstract
A fundamental feature of the mammalian neocortex is its columnar organization. In the visual cortex, functional columns consisting of neurons with similar orientation preferences have been characterized extensively, but how these columns are constructed during development remains unclear. The radial unit hypothesis posits that the ontogenetic columns formed by clonally related neurons migrating along the same radial glial fibre during corticogenesis provide the basis for functional columns in adult neocortex. However, a direct correspondence between the ontogenetic and functional columns has not been demonstrated. Here we show that, despite the lack of a discernible orientation map in mouse visual cortex, sister neurons in the same radial clone exhibit similar orientation preferences. Using a retroviral vector encoding green fluorescent protein to label radial clones of excitatory neurons, and in vivo two-photon calcium imaging to measure neuronal response properties, we found that sister neurons preferred similar orientations whereas nearby non-sister neurons showed no such relationship. Interestingly, disruption of gap junction coupling by viral expression of a dominant-negative mutant of Cx26 (also known as Gjb2) or by daily administration of a gap junction blocker, carbenoxolone, during the first postnatal week greatly diminished the functional similarity between sister neurons, suggesting that the maturation of ontogenetic into functional columns requires intercellular communication through gap junctions. Together with the recent finding of preferential excitatory connections among sister neurons, our results support the radial unit hypothesis and unify the ontogenetic and functional columns in the visual cortex.
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- 2012
13. Neurite regrowth stimulation by a red-light spot focused on the neuronal cell soma following blue light-induced retraction
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Kao, Yu-Chiu, Liao, Yu-Cing, Cheng, Pei-Lin, and Lee, Chau-Hwang
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- 2019
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14. BodyTracker: A Deep Learning Based 3D Limb Trajectory Tracking System for Rehabilitation.
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Wan-Jung Chang, Jian-Ping Su, Liang-Bi Chen, Chia-Hao Hsu, Cheng-Pei Lin, Tzu-Chin Yang, Ming-Che Chen, and Yang-Kun Ou
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- 2019
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15. BOS1c.001 Is self-efficacy associated with readiness to engage advance care planning among medical university students in Taiwan?
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Cheng-Pei Lin, Jung-Yu Liao, Chao A Hsiung, Sang-Ju Yu, and Ping-Jen Chen
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- 2023
16. Supplementary Figures 1-4 from DDX3, a DEAD Box RNA Helicase with Tumor Growth–Suppressive Property and Transcriptional Regulation Activity of the p21waf1/cip1 Promoter, Is a Candidate Tumor Suppressor
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Chao, Chi-Hong, primary, Chen, Chun-Ming, primary, Cheng, Pei-Lin, primary, Shih, Jing-Wen, primary, Tsou, Ann-Ping, primary, and Wu Lee, Yan-Hwa, primary
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- 2023
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17. Data from DDX3, a DEAD Box RNA Helicase with Tumor Growth–Suppressive Property and Transcriptional Regulation Activity of the p21waf1/cip1 Promoter, Is a Candidate Tumor Suppressor
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Chao, Chi-Hong, primary, Chen, Chun-Ming, primary, Cheng, Pei-Lin, primary, Shih, Jing-Wen, primary, Tsou, Ann-Ping, primary, and Wu Lee, Yan-Hwa, primary
- Published
- 2023
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18. Asian patients’ perspectives on advance care planning
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Wichor M. Bramer, Ida J. Korfage, Cheng Pei Lin, Olaf P. Geerse, Martina Sinta Kristanti, Agnes van der Heide, Diah Martina, Masanori Mori, Carin C.D. van der Rijt, and Judith A.C. Rietjens
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Advance care planning ,Health professionals ,business.industry ,Communication ,Health Personnel ,General Medicine ,Patient preference ,Advance Care Planning ,Anesthesiology and Pain Medicine ,Nursing ,Conceptual framework ,Asian People ,systematic review ,attitude ,Critical illness ,Medicine ,Humans ,critical illness ,mixed design ,Patient Participation ,business ,Review Articles ,Asian continental ancestry group ,patient preference - Abstract
Background:Asian healthcare professionals hold that patients’ families play an essential role in advance care planning.Aim:To systematically synthesize evidence regarding Asian patients’ perspectives on advance care planning and their underlying motives.Design:Mixed-method systematic review and the development of a conceptual framework (PROSPERO: CRD42018099980).Data sources:EMBASE, MEDLINE, Web of Science, and Google Scholar were searched for studies published until July 27, 2020. We included studies concerning seriously-ill Asian patients’ perspectives on advance care planning or their underlying motives for engaging or not engaging in it.Results:Thirty-six articles were included; 22 were quantitative and 27 were from high-income countries. Thirty-nine to ninety percent of Asian patients were willing to engage in advance care planning. Our framework highlighted that this willingness was influenced not only by their knowledge of their disease and of advance care planning, but also by their beliefs regarding: (1) its consequences; (2) whether its concept was in accordance with their faith and their families’ or physicians’ wishes; and (3) the presence of its barriers. Essential considerations of patients’ engagement were their preferences: (1) for being actively engaged or, alternatively, for delegating autonomy to others; (2) the timing, and (3) whether or not the conversations would be documented.Conclusion:The essential first step to engaging patients in advance care planning is to educate them on it and on their diseases. Asian patients’ various beliefs about advance care planning should be accommodated, especially their preferences regarding their role in it, its timing, and its documentation.
- Published
- 2021
19. Letter to the Editor: Improving Access to Advance Care Planning in Current and Future Public Health Emergencies: International Challenges and Recommendations
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Cheng-Pei Lin, Jen-Kuei Peng, Wan-Ting Hsieh, Diah Martina, Masanori Mori, Sayaka Takenouchi, Helen Yue-Lai Chan, Sang-Yeon Suh, Sun-Hyun Kim, Kwok-Keung Yuen, Yoshiyuki Kizawa, and Shao-Yi Cheng
- Subjects
Anesthesiology and Pain Medicine ,General Medicine ,General Nursing - Published
- 2023
20. Neuronal paxillin and drebrin mediate BDNF-induced force transduction and growth cone turning in a soft-tissue-like environment
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Chen, Chen, primary, Chu, Chien-Hsin, additional, Chu, Ying, additional, Chang, Ting-Ya, additional, Chen, Sheng-Wen, additional, Liang, Shu-Yang, additional, Tsai, Yun-Chi, additional, Chen, Bi-Chang, additional, Tu, Hsiung-Lin, additional, and Cheng, Pei-Lin, additional
- Published
- 2022
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21. Caring at the Culture and Spirituality Interface
- Author
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Richard A. Powell, Cheng-Pei Lin, Ping Guo, and Eve Namisango
- Abstract
Palliative care is premised on the keystone principle that “total pain” involves suffering in the potentially reciprocally impacting physical, psychological, social, and spiritual domains. It is, therefore, underpinned by a multidimensional, biopsychosocial-spiritual model of care provision. Palliative care providers should not simply assess and manage these multiple domains of patient suffering holistically—including end-of-life spiritual concerns—but do so with a cognisance of, and sensitivity to, prevailing cultural practices and expectations within which the patient, their family and community, exist. This chapter explores palliative care provision at the interface between culture and spirituality, using four brief case studies from China, Taiwan, New Zealand, and sub-Saharan Africa. Insufficient research exists on culturally safe approaches to palliative care, especially among indigenous populations, as determinants of expectations and experiences of service users, and how services are organized and delivered. Similarly, more research is needed regarding the models of spiritual care provision, how death and the dying process are understood, how people find meaning in illness, and the preferred communication and rituals surrounding and planning for death. The chapter therefore proposes the need for research into the culture–spirituality–palliative care nexus. It concludes that by being sensitive to patients’ spiritual and cultural needs and wants, palliative care practitioners acquire the insights and understanding necessary to provide holistic care for the whole person, to address their suffering in its totality, in accord with the biopsychosocial-spiritual model of care provision, as well as helping ensure that their dignity, right to self-determination, and autonomy are respected.
- Published
- 2022
22. How is community based ‘out-of-hours’ care provided to patients with advanced illness near the end of life: A systematic review of care provision.
- Author
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Firth, Alice M., Cheng-Pei Lin, Deok Hee Yi, Goodrich, Joanna, Gaczkowska, Inez, Waite, Frances, Harding, Richard, Murtagh, Fliss E. M., and Evans, Catherine J.
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EVALUATION of medical care , *PSYCHOLOGY information storage & retrieval systems , *CINAHL database , *MEDICAL information storage & retrieval systems , *SYSTEMATIC reviews , *RESEARCH methodology , *COMMUNITY health services , *MEDICAL care , *FAMILIES , *COST benefit analysis , *COMPARATIVE studies , *RESEARCH funding , *DEATH , *THEMATIC analysis , *MEDLINE , *PALLIATIVE treatment , *LONGITUDINAL method , *EVALUATION - Abstract
Background: Deaths in the community are increasing. However, community palliative care out-of-hours is variable. We lack detailed understanding of how care is provided out-of-hours and the associated outcomes. Aim: To review systematically the components, outcomes and economic evaluation of community-based ‘out-of-hours’ care for patients near the end of life and their families. Design: Mixed method systematic narrative review. Narrative synthesis, development and application of a typology to categorise out-of-hours provision. Qualitative data were synthesised thematically and integrated at the level of interpretation and reporting. Data sources: Systematic review searching; MEDLINE, EMBASE, PsycINFO, CINAHL from January 1990 to 1st August 2022. Results: About 64 publications from 54 studies were synthesised (from 9259 retrieved). Two main themes were identified: (1) importance of being known to a service and (2) high-quality coordination of care. A typology of out-of-hours service provision was constructed using three overarching dimensions (service times, focus of team delivering the care and type of care delivered) resulting in 15 categories of care. Only nine papers were randomised control trials or controlled cohorts reporting outcomes. Evidence on effectiveness was apparent for providing 24/7 specialist palliative care with both hands-on clinical care and advisory care. Only nine publications reported economic evaluation. Conclusions: The typological framework allows models of out-of-hours care to be systematically defined and compared. We highlight the models of out-of-hours care which are linked with improvement of patient outcomes. There is a need for effectiveness and cost effectiveness studies which define and categorise out-of-hours care to allow thorough evaluation of services. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
23. Surface Viscosity‐Dependent Neurite Initiation in Cortical Neurons
- Author
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Kao, Shih‐Han, primary, Liang, Shu‐Yang, additional, Cheng, Pei‐Lin, additional, and Tu, Hsiung‐Lin, additional
- Published
- 2022
- Full Text
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24. Self-amplifying autocrine actions of BDNF in axon development
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Cheng, Pei-Lin, Song, Ai-Hong, Wong, Yu-Hui, Wang, Sheng, Zhang, Xiang, and Poo, Mu-Ming
- Published
- 2011
25. Comment on: 'Advance' care planning reenvisioned
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Fliss E M Murtagh, Cheng Pei Lin, Clarissa Penfold, Mevhibe Hocaoglu, Joanne Bayly, Jonathan Koffman, Adejoke O Oluyase, and Andy Bradshaw
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Advance care planning ,Advance Care Planning ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Humans ,Medicine ,Medical emergency ,Geriatrics and Gerontology ,Advance Directives ,business ,medicine.disease - Published
- 2021
26. A Comparison of the Survival, Place of Death, and Medical Utilization of Terminal Patients Receiving Hospital-Based and Community-Based Palliative Home Care: A Retrospective and Propensity Score Matching Cohort Study
- Author
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Min Shiow Tsay, Cheng Pei Lin, Hung Cheng Chen, Chien Yi Wu, Yun Shiuan Chuang, Ching Yu Wang, and Yi Hui Chang
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medicine.medical_specialty ,Health, Toxicology and Mutagenesis ,education ,Staffing ,Taiwan ,community-based palliative home care ,Nurse visits ,behavioral disciplines and activities ,survival ,Article ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,030502 gerontology ,medicine ,Humans ,030212 general & internal medicine ,Propensity Score ,Aged ,Retrospective Studies ,Community based ,business.industry ,medical utilization ,Public Health, Environmental and Occupational Health ,Hospices ,Retrospective cohort study ,Hospital based ,Home Care Services ,Place of death ,Emergency medicine ,Propensity score matching ,Medicine ,hospital-based palliative home care ,0305 other medical science ,business ,place of death ,Cohort study - Abstract
Evidence shows that community-based palliative home care (PHC) provision enhances continuous care and improves patient outcomes. This study compared patient survival, place of death, and medical utilization in community- versus hospital-based PHC. A retrospective cohort study was conducted of patients aged over 18 referred to either community- or hospital-based PHC from May to December 2018 at a tertiary hospital and surrounding communities in Southern Taiwan. A descriptive analysis, Chi-square test, t-test, and Log-rank test were used for the data analysis of 131 hospital-based PHC patients and 43 community-based PHC patients, with 42 paired patient datasets analyzed after propensity score matching. More nurse visits (p = 0.02), fewer emergency-room visits (p = 0.01), and a shorter waiting time to access PHC (p = 0.02) were found in the community group. There was no difference in the duration of survival and hospitalization between groups. Most hospital-based patients (57%) died in hospice wards, while most community-based patients died at home (52%). Community-based PHC is comparable to hospital-based PHC in Taiwan. Although it has fewer staffing and training requirements, it is an alternative for terminal patients to meet the growing end-of-life care demand.
- Published
- 2021
27. What influences patients’ decisions regarding palliative care in advance care planning discussions? Perspectives from a qualitative study conducted with advanced cancer patients, families and healthcare professionals
- Author
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Richard Harding, Cheng Pei Lin, Shuh Jen Sheu, Su Hsuan Hsu, Jonathan Koffman, and Catherine J Evans
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Adult ,Male ,Advance care planning ,Palliative care ,Attitude of Health Personnel ,Taiwan ,Pain ,Health Services Accessibility ,Advance Care Planning ,03 medical and health sciences ,0302 clinical medicine ,Nursing ,Neoplasms ,Humans ,Medicine ,Family ,030212 general & internal medicine ,Decision-making ,Qualitative Research ,Aged ,Aged, 80 and over ,Terminal Care ,Health professionals ,business.industry ,Palliative Care ,Cancer ,General Medicine ,Middle Aged ,Patient Acceptance of Health Care ,medicine.disease ,Advanced cancer ,Anesthesiology and Pain Medicine ,030220 oncology & carcinogenesis ,Female ,Clinical Competence ,business ,Qualitative research - Abstract
Background: The concept of advance care planning is largely derived from Western countries. However, the decision-making process and drivers for choosing palliative care in non-Western cultures have received little attention. Aim: To explore the decision-making processes and drivers of receiving palliative care in advance care planning discussions from perspectives of advanced cancer patients, families and healthcare professionals in northern Taiwan. Method: Semi-structured qualitative interviews with advanced cancer patients, their families and healthcare professionals independently from inpatient oncology and hospice units. Thematic analysis with analytical rigour enhanced by dual coding and exploration of divergent views. Results: Forty-five participants were interviewed ( n = 15 from each group). Three main decision-making trajectories were identified: (1) ‘choose palliative care’ was associated with patients’ desire to reduce physical suffering from treatments, avoid being a burden to families and society, reduce futile treatments and donate organs to help others; (2) ‘decline palliative care’ was associated with patients weighing up perceived benefits to others as more important than benefits for themselves; and (3) ‘no opportunity to choose palliative care’ was associated with lack of opportunities to discuss potential benefits of palliative care, lack of staff skill in end-of-life communication, and cultural factors, notably filial piety. Conclusion: Choice for palliative care among advanced cancer patients in Taiwan is influenced by three decision-making trajectories. Opinions from families are highly influential, and patients often lack information on palliative care options. Strategies to facilitate decision-making require staff confidence in end-of-life discussions, working with the patients and their family while respecting the influence of filial piety.
- Published
- 2019
28. Relay of cyclin-dependent kinases in the regulation of axonal growth
- Author
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Chang, Ting-Ya and Cheng, Pei-Lin
- Published
- 2015
- Full Text
- View/download PDF
29. Second messenger signaling for neuronal polarization: Cell mechanics-dependent pattern formation
- Author
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Guo, Chin-Lin and Cheng, Pei-Lin
- Published
- 2015
- Full Text
- View/download PDF
30. Preparedness to Face the COVID-19 Pandemic in Hospice and Palliative Care Services in the Asia-Pacific Region: A Rapid Online Survey
- Author
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Ednin Hamzah, Ghauri Aggarwal, Cynthia Goh, Cheng Pei Lin, Richard Harding, Irene J Higginson, Yoshiyuki Kizawa, Sabah Boufkhed, Masanori Mori, and Eve Namisango
- Subjects
Palliative care ,Asia ,Coronavirus disease 2019 (COVID-19) ,Life quality ,Face (sociological concept) ,Asia pacific region ,epidemic ,Nursing ,Surveys and Questionnaires ,Pandemic ,Medicine ,Humans ,Limited evidence ,Pandemics ,business.industry ,pandemic ,Palliative Care ,Hospices ,COVID-19 ,General Medicine ,preparedness ,Cross-Sectional Studies ,Hospice Care ,hospice and palliative care ,Preparedness ,business ,Asia-Pacific region - Abstract
Background: Hospice and palliative care services provision for COVID-19 patients is crucial to improve their life quality. There is limited evidence on COVID-19 preparedness of such services in the Asia-Pacific region. Aim: To evaluate the preparedness and capacity of hospice and palliative care services in the Asia-Pacific region to respond to the COVID-19 pandemic. Method: An online cross-sectional survey was developed based on methodology guidance. Asia-Pacific Hospice and Palliative Care Network subscribers (n = 1551) and organizational members (n = 185) were emailed. Descriptive analysis was undertaken. Results: Ninety-seven respondents completed the survey. Around half of services were hospital-based (n = 47, 48%), and public-funded (n = 46, 47%). Half of services reported to have confirmed cases (n = 47, 49%) and the majority of the confirmed cases were patients (n = 28, 61%). Staff perceived moderate risk of being infected by COVID-19 (median: 7/10). > 85% of respondents reported they had up-to-date contact list for staff and patients, one-third revealed challenges to keep record of relatives who visited the services (n = 30, 31%), and of patients visited in communities (n = 29, 30%). Majority of services (60%) obtained adequate resources for infection control except face mask. More than half had no guidance on Do Not Resuscitate orders (n = 59, 66%) or on bereavement care for family members (n = 44, 51%). Conclusion: Recommendations to strengthen the preparedness of palliative care services include: 1) improving the access to face mask; 2) acquiring stress management protocols for staff when unavailable; 3) reinforcing the contact tracing system for relatives and visits in the community and 4) developing guidance on patient and family care during patient’s dying trajectory.
- Published
- 2021
31. The Characteristics and Motivations of Taiwanese People toward Advance Care Planning in Outpatient Clinics at a Community Hospital
- Author
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Chih Chieh Yen, Bing Sheng Lin, Jin Shang Wu, Chiu Hua Tsu, Cheng Pei Lin, Zih Jie Sun, Li Mei Chang, and Yu Ting Su
- Subjects
Male ,Advance care planning ,medicine.medical_specialty ,Health, Toxicology and Mutagenesis ,Taiwan ,lcsh:Medicine ,Hospitals, Community ,Artificial nutrition ,Logistic regression ,Ambulatory Care Facilities ,Article ,03 medical and health sciences ,0302 clinical medicine ,Humans ,Medicine ,Outpatient clinic ,030212 general & internal medicine ,Organ donation ,advance care planning ,Retrospective Studies ,Motivation ,business.industry ,lcsh:R ,Public Health, Environmental and Occupational Health ,Middle Aged ,Community hospital ,030220 oncology & carcinogenesis ,Family medicine ,hospice and palliative care ,Community setting ,Female ,Residence ,advance decisions ,business ,community hospital - Abstract
Advance care planning (ACP) provides access to complete advance decisions (ADs). Despite the legalization of ACP in Taiwan, it is underutilized in community settings. The objective of this study is to describe the service at a community hospital in Southern Taiwan. We retrospectively analyzed participants who were engaged in ACP consultations from January 2019 to January 2020. The characteristics, motivations, content, and satisfaction of participants are reported. Factors associated with refusing life-sustaining treatments (LST) or artificial nutrition/hydration (ANH) were analyzed using multivariate logistic regression. Of the 178 participants, 123 completed the ACP. The majority were female (64.2%), aged 61 on average and more than 80% had never signed a do-not-resuscitate order. In the ADs, most participants declined LST (97.2%) and ANH (96.6%). Family-related issues (48.9%) were the most prevalent motivations. Rural residence (OR 8.6, p = 0.005), increased age (OR 7.2, p = 0.025), and reluctance to consent to organ donation (OR 5.2, p = 0.042) correlated with refusing LST or ANH. Participants provided a positive feedback regarding overall satisfaction (good, 83%) compared to service charge (fair/poor, 53%). The study demonstrated high AD completion when refusing LST or ANH. These findings may facilitate the development of ACP as a community-based service.
- Published
- 2021
32. Advance Care Planning In The Asia Pacific
- Author
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Raymond Han Lip Ng, Diah Martina, Cheng-pei Lin, Masanori Mori, Raymond Han Lip Ng, Diah Martina, Cheng-pei Lin, and Masanori Mori
- Subjects
- Medical personnel and patient--Pacific Area, Patient-centered health care--Pacific Area, Advance directives (Medical care)--Social aspects--Pacific Area
- Abstract
The 21st century is facing an unprecedented trend of population aging, including in many regions in the Asia Pacific region. Governments and healthcare systems recognise the importance of Advance Care Planning (ACP) in helping people to live well and to leave well.ACP is a complex intervention that is culture and context specific. In our universal endeavour to engender person centred care in healthcare systems and a more compassionate society, we are more similar than different. In this day and age of fast developing medical technologies and evolving social norms, ACP brims with both challenges and potential and a renewed understanding is needed.This book is a paean to the multifaceted nature of ACP as well as a timely update regarding the current landscape of ACP implementation and practice across the Asia Pacific region.
- Published
- 2024
33. Supplemental Material, sj-pdf-1-ajh-10.1177_10499091211002797 - Preparedness to Face the COVID-19 Pandemic in Hospice and Palliative Care Services in the Asia-Pacific Region: A Rapid Online Survey
- Author
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Cheng-Pei Lin, Boufkhed, Sabah, Kizawa, Yoshiyuki, Mori, Masanori, Ednin Hamzah, Ghauri Aggarwal, Namisango, Eve, Higginson, Irene J., Goh, Cynthia, and Harding, Richard
- Subjects
111099 Nursing not elsewhere classified ,111702 Aged Health Care ,FOS: Health sciences - Abstract
Supplemental Material, sj-pdf-1-ajh-10.1177_10499091211002797 for Preparedness to Face the COVID-19 Pandemic in Hospice and Palliative Care Services in the Asia-Pacific Region: A Rapid Online Survey by Cheng-Pei Lin, Sabah Boufkhed, Yoshiyuki Kizawa, Masanori Mori, Ednin Hamzah, Ghauri Aggarwal, Eve Namisango, Irene J. Higginson, Cynthia Goh and Richard Harding in American Journal of Hospice and Palliative Medicine®
- Published
- 2021
- Full Text
- View/download PDF
34. Preferences on the Timing of Initiating Advance Care Planning and Withdrawing Life-Sustaining Treatment between Terminally-Ill Cancer Patients and Their Main Family Caregivers: A Prospective Study
- Author
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Cheng Pei Lin, Shao-Yi Cheng, Su Hsuan Hsu, Jen Kuei Peng, Hsien Liang Huang, and Ping-Jen Chen
- Subjects
Male ,Advance care planning ,medicine.medical_specialty ,Asia ,Palliative care ,medical decision-making ,Health, Toxicology and Mutagenesis ,media_common.quotation_subject ,Taiwan ,lcsh:Medicine ,Disease ,Article ,relational autonomy ,03 medical and health sciences ,0302 clinical medicine ,Neoplasms ,medicine ,Humans ,terminal cancer ,Prospective Studies ,030212 general & internal medicine ,Prospective cohort study ,advance care planning ,Aged ,media_common ,Family Health ,Terminal Care ,Descriptive statistics ,Family caregivers ,business.industry ,lcsh:R ,Public Health, Environmental and Occupational Health ,Questionnaire ,Middle Aged ,life-sustaining treatment ,Caregivers ,030220 oncology & carcinogenesis ,Family medicine ,Female ,business ,Autonomy - Abstract
Background: The Western individualistic understanding of autonomy for advance care planning is considered not to reflect the Asian family-centered approach in medical decision-making. The study aim is to compare preferences on timing for advance care planning initiatives and life-sustaining treatment withdrawal between terminally-ill cancer patients and their family caregivers in Taiwan. Methods: A prospective study using questionnaire survey was conducted with both terminally-ill cancer patient and their family caregiver dyads independently in inpatient and outpatient palliative care settings in a tertiary hospital in Northern Taiwan. Self-reported questionnaire using clinical scenario of incurable lung cancer was employed. Descriptive analysis was used for data analysis. Results: Fifty-four patients and family dyads were recruited from 1 August 2019 to 15 January 2020. Nearly 80% of patients and caregivers agreed that advance care planning should be conducted when the patient was at a non-frail stage of disease. Patients&rsquo, frail stage of disease was considered the indicator for life-sustaining treatments withdrawal except for nutrition and fluid supplements, antibiotics or blood transfusions. Patient dyads considered that advance care planning discussions were meaningful without arousing emotional distress. Conclusion: Patient dyads&rsquo, preferences on the timing of initiating advance care planning and life-sustaining treatments withdrawal were found to be consistent. Taiwanese people&rsquo, s medical decision-making is heavily influenced by cultural characteristics including relational autonomy and filial piety. The findings could inform the clinical practice and policy in the wider Asia&ndash, Pacific region.
- Published
- 2020
- Full Text
- View/download PDF
35. Feasibility and acceptability of a culturally adapted advance care planning intervention for people living with advanced cancer and their families:A mixed methods study
- Author
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Richard Harding, Cheng Pei Lin, Ping-Jen Chen, Jonathan Koffman, Ming Feng Hou, and Catherine J Evans
- Subjects
Advance care planning ,medicine.medical_specialty ,feasibility and acceptability ,Palliative care ,Taiwan ,cultural adaptation ,Advance Care Planning ,Neoplasms ,Intervention (counseling) ,Humans ,Medicine ,cancer ,Family ,Terminal Care ,Cultural Characteristics ,palliative care ,business.industry ,Cancer ,General Medicine ,medicine.disease ,Advanced cancer ,Anesthesiology and Pain Medicine ,Family medicine ,Feasibility Studies ,business - Abstract
Background: Increasing evidence shows that advance care planning is effective in improving outcomes. However, its applicability and acceptability outside Western cultures remain unknown. Examination of relevant cultural adaptations is required prior to wider adoption. Aim: To examine the feasibility and acceptability of a culturally adapted advance care planning intervention in a Taiwanese inpatient hospital for advanced cancer patients, family members and healthcare professionals. Methods: A single-group, non-controlled, mixed methods feasibility study guided by a previously developed logic model. The culturally adapted advance care planning intervention represented a one-time intervention, comprising pre-advance care planning preparation and follow-up consultation. Qualitative interviews explored participants’ view on their involvement in the study. Patients’ medical records were examined to assess intervention fidelity. Findings from both data sets were integrated following analysis. Results: N = 29 participants ( n = 10 patients; n = 10 family members and n = 9 healthcare professionals) participated in the intervention, of who 28 completed follow-up interviews. Of the 10 advance care planning interventions delivered, most components ( n = 10/13) were met. Key contextual moderators influencing the intervention feasibility included: (1) resource constraints resulting in increased workload; (2) care decisions informed by relatives’ experiences of care; (3) the requirement for financial and policy support; and (4) a presumption for end-of-life care provision and surrogate decision-making. Six areas of intervention refinement were identified for future research. Conclusion: Implementing a culturally adapted advance care planning intervention in an inpatient hospital setting in Taiwan is possible. The participants reported the intervention to be acceptable. However, careful attention to the conceptual underpinning using local primary data is imperative for its success.
- Published
- 2020
36. Research on the Requirements of Mobile Radio APP for the Elderly Based on Kano Model
- Author
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Xin-Hui Hong and Cheng-Pei Lin
- Subjects
Mobile radio ,Multimedia ,Computer science ,business.industry ,Design elements and principles ,Aging society ,Total population ,computer.software_genre ,User Research ,User experience design ,Kano model ,Mobile station ,business ,computer - Abstract
The Kano model is used to explore the needs of the elderly for mobile station APP. First of all, through user research and analysis of the elderly users of the use process of the requirements. Secondly, we use the method of Kano model questionnaire to screen and classify the demand items, convert the user’s demand into design elements, calculate the weight of attractive demand items by entropy method, rank the importance, and determine the key design elements. Finally, the interactive prototype of mobile station APP is proposed. The application research of mobile station APP for the aged integrated with Kano model not only provides good user experience for the aged users, but also provides theoretical basis and objective data for the design of similar products. China has already entered the aging society, according to the expert conjecture, our country aging problem will reach the serious stage by 2020, and in 2050, our country aged population will account for one fifth of the total population [1]. Old people used to be the main users of radio products, but most of the users of the existing mobile station APP products were teenagers and middle-aged people, while the old people were few. In order to provide the elderly with a good user experience of mobile radio products, this paper uses Kano model to analyze the needs of elderly users and apply it in design practice.
- Published
- 2020
37. MOESM6 of A robust TDP-43 knock-in mouse model of ALS
- Author
-
Shih-Ling Huang, Lien-Szu Wu, Lee, Min, Chin-Wen Chang, Cheng, Wei-Cheng, Fang, Yu-Sheng, Yun-Ru Chen, Cheng, Pei-Lin, and Che-Kun Shen
- Abstract
Additional file 6: Figure S6. Decreased of p62 protein level and enhanced of the proteasome activities in the spinal cord, but not the forebrain, of symptomatic N390D/+ mice.
- Published
- 2020
- Full Text
- View/download PDF
38. The conceptual models and mechanisms of action that underpin advance care planning for cancer patients: A systematic review of randomised controlled trials
- Author
-
Jo Armes, Jonathan Koffman, Catherine J Evans, Richard Harding, Fliss E M Murtagh, and Cheng Pei Lin
- Subjects
Adult ,Male ,Advance care planning ,Underpinning ,Decision Making ,MEDLINE ,CINAHL ,PsycINFO ,Logic model ,Advance Care Planning ,03 medical and health sciences ,0302 clinical medicine ,Nursing ,030502 gerontology ,Neoplasms ,Humans ,cancer ,Medicine ,advance care planning ,Review Articles ,Competence (human resources) ,Aged ,Randomized Controlled Trials as Topic ,Aged, 80 and over ,Terminal Care ,business.industry ,General Medicine ,Middle Aged ,conceptual models ,mechanisms of action ,Anesthesiology and Pain Medicine ,Action (philosophy) ,030220 oncology & carcinogenesis ,Systematic review ,Female ,Patient Participation ,0305 other medical science ,business - Abstract
Background: No systematic review has focused on conceptual models underpinning advance care planning for patients with advanced cancer, and the mechanisms of action in relation to the intended outcomes. Aim: To appraise conceptual models and develop a logic model of advance care planning for advanced cancer patients, examining the components, processes, theoretical underpinning, mechanisms of action and linkage with intended outcomes. Design: A systematic review of randomised controlled trials was conducted, and was prospectively registered on PROSPERO. Narrative synthesis was used for data analysis. Data sources: The data sources were MEDLINE, CINAHL, PsycINFO, EMBASE, CENTRAL, PROSPERO, CareSearch, and OpenGrey with reference chaining and hand-searching from inception to 31 March 2017, including all randomised controlled trials with advance care planning for cancer patients in the last 12 months of life. Cochrane quality assessment tool was used for quality appraisal. Results: Nine randomised controlled trials were included, with only four articulated conceptual models. Mechanisms through which advance care planning improved outcomes comprised (1) increasing patients’ knowledge of end-of-life care, (2) strengthening patients’ autonomous motivation, (3) building patients’ competence to undertake end-of-life discussions and (4) enhancing shared decision-making in a trustful relationship. Samples were largely highly educated Caucasian. Conclusion: The use of conceptual models underpinning the development of advance care planning is uncommon. When used, they identify the individual behavioural change. Strengthening patients’ motivation and competence in participating advance care planning discussions are key mechanisms of change. Understanding cultural feasibility of the logic model for different educational levels and ethnicities in non-Western countries should be a research priority.
- Published
- 2018
39. Advance care planning in Asian culture
- Author
-
R Ng, Helen Y.L. Chan, Sun Hyun Kim, Shao-Yi Cheng, Diah Martina, Masanori Mori, Cheng Pei Lin, Medical Oncology, and Public Health
- Subjects
Advance care planning ,Male ,Cancer Research ,Aging ,Palliative care ,media_common.quotation_subject ,03 medical and health sciences ,Advance Care Planning ,0302 clinical medicine ,Asian People ,Health care ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,East Asia ,030212 general & internal medicine ,Family values ,media_common ,Aged ,Terminal Care ,business.industry ,General Medicine ,Public relations ,Dilemma ,Oncology ,030220 oncology & carcinogenesis ,Female ,business ,End-of-life care ,Autonomy - Abstract
Ageing has been recognized as one of the most critically important health-care issues worldwide. It is relevant to Asia, where the increasing number of older populations has drawn attention to the paramount need for health-care investment, particularly in end-of-life care. The advocacy of advance care planning is a mean to honor patient autonomy. Since most East Asian countries are influenced by Confucianism and the concept of ‘filial piety,’ patient autonomy is consequently subordinate to family values and physician authority. The dominance from family members and physicians during a patient’s end-of-life decision-making is recognized as a cultural feature in Asia. Physicians often disclose the patient’s poor prognosis and corresponding treatment options to the male, family member rather to the patient him/herself. In order to address this ethical and practical dilemma, the concept of ‘relational autonomy’ and the collectivism paradigm might be ideally used to assist Asian people, especially older adults, to share their preferences on future care and decision-making on certain clinical situations with their families and important others. In this review article, we invited experts in end-of-life care from Hong Kong, Indonesia, Japan, South Korea, Singapore and Taiwan to briefly report the current status of advance care planning in each country from policy, legal and clinical perspectives. According to the Asian experiences, we have seen different models of advance care planning implementation. The Asian Delphi Taskforce for advance care planning is currently undertaken by six Asian countries and a more detailed, culturally sensitive whitepaper will be published in the near future.
- Published
- 2019
40. Genetic polymorphisms of viral infection-associated Toll-like receptors in Chinese population
- Author
-
Cheng, Pei-Lin, Eng, Hock-Liew, Chou, Ming-Huei, You, Huey-Ling, and Lin, Tsun-Mei
- Published
- 2007
- Full Text
- View/download PDF
41. Hepatitis C viral proteins interact with Smad3 and differentially regulate TGF-β/Smad3-mediated transcriptional activation
- Author
-
Cheng, Pei-Lin, Chang, Meng-Hsiung, Chao, Chi-Hong, and Lee, Yan-Hwa Wu
- Published
- 2004
- Full Text
- View/download PDF
42. Ecm29-mediated proteasomal distribution modulates excitatory GABA responses in the developing brain
- Author
-
Lee, Min, primary, Liu, Yen-Chen, additional, Chen, Chen, additional, Lu, Chi-Huan, additional, Lu, Shao-Tzu, additional, Huang, Tzyy-Nan, additional, Hsu, Meng-Tsung, additional, Hsueh, Yi-Ping, additional, and Cheng, Pei-Lin, additional
- Published
- 2020
- Full Text
- View/download PDF
43. BodyTracker: A Deep Learning Based 3D Limb Trajectory Tracking System for Rehabilitation
- Author
-
Chia-Hao Hsu, Yang-Kun Ou, Jian-Ping Su, Liang-Bi Chen, Ming-Che Chen, Wan-Jung Chang, Cheng-Pei Lin, and Tzu-Chin Yang
- Subjects
Rehabilitation ,Stroke patient ,business.industry ,Computer science ,medicine.medical_treatment ,Deep learning ,education ,05 social sciences ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,020207 software engineering ,Tracking system ,02 engineering and technology ,0202 electrical engineering, electronic engineering, information engineering ,Trajectory ,medicine ,0501 psychology and cognitive sciences ,Computer vision ,Artificial intelligence ,business ,050107 human factors - Abstract
In this paper, we propose a 3D limb trajectory tracking system, named BodyTracker, which is based on deep learning techniques for assisting rehabilitation. The proposed BodyTracker is composed of two limbs recognition camera and a deep learning training server. As a result, the proposed system can provide medical personnel with an effective way to assess the effectiveness of rehabilitation for stroke patients.
- Published
- 2019
44. Recommendations for the Delivery of Advance Care Planning for Cancer Patients in Taiwan: Result of a Transparent Expert Consultation
- Author
-
Cheng-Pei Lin
- Published
- 2019
45. What Influences a Patient's Decisions to Receive Palliative Care as Part of Advance Care Planning? Qualitative Perspectives from Advanced Cancer Patients, Families and Healthcare Professionals in Taiwan
- Author
-
Cheng-Pei Lin
- Published
- 2019
46. 2019 Taipei Declaration on Advance Care Planning: A Cultural Adaptation of End-of-Life Care Discussion
- Author
-
Jaw-Shiun Tsai, Tai-Yuan Chiu, Sang Yeon Suh, Annie Oi Ling Kwok, Tatsuya Morita, Kwok Keung Yuen, Sumytra Menon, Chien Yi Wu, Yoshiyuki Kizawa, Ping-Jen Chen, Wen-Yu Hu, Chien-An Yao, Su Hsuan Hsu, Hsueh Lin Ho, Cheng Pei Lin, Helen Y.L. Chan, Shao-Yi Cheng, Jen Kuei Peng, Jung Young Kim, Ying Wei Wang, Chih Yuan Shih, Shimon Tashiro, Grace Su Yin Pang, Diah Martina, Sayaka Takenouchi, Sun Hyun Kim, Hsien Liang Huang, Masanori Mori, Raymond Ng-Han Lip, Weng Sun Pang, Futoshi Iwata, and Public Health
- Subjects
Advance care planning ,Terminal Care ,Cultural Characteristics ,business.industry ,Declaration ,MEDLINE ,Taiwan ,General Medicine ,Advance Care Planning ,Anesthesiology and Pain Medicine ,Nursing ,Terminal care ,Medicine ,Humans ,business ,Adaptation (computer science) ,End-of-life care ,General Nursing - Published
- 2019
47. 040419_Supplementary_materials – Supplemental material for What influences patients’ decisions regarding palliative care in advance care planning discussions? Perspectives from a qualitative study conducted with advanced cancer patients, families and healthcare professionals
- Author
-
Cheng-Pei Lin, Evans, Catherine J, Koffman, Jonathan, Shuh-Jen Sheu, Su-Hsuan Hsu, and Harding, Richard
- Subjects
FOS: Clinical medicine ,111702 Aged Health Care ,FOS: Health sciences ,110308 Geriatrics and Gerontology - Abstract
Supplemental material, 040419_Supplementary_materials for What influences patients’ decisions regarding palliative care in advance care planning discussions? Perspectives from a qualitative study conducted with advanced cancer patients, families and healthcare professionals by Cheng-Pei Lin, Catherine J Evans, Jonathan Koffman, Shuh-Jen Sheu, Su-Hsuan Hsu and Richard Harding in Palliative Medicine
- Published
- 2019
- Full Text
- View/download PDF
48. Advance Care Planning in Asia: A Systematic Narrative Review of Healthcare Professionals’ Knowledge, Attitude, and Experience
- Author
-
Wichor M. Bramer, Carin C.D. van der Rijt, Martina Sinta Kristanti, Masanori Mori, Agnes van der Heide, Judith A.C. Rietjens, Diah Martina, Cheng Pei Lin, Ida J. Korfage, Medical Oncology, Public Health, and Erasmus MC other
- Subjects
Advance care planning ,Health Knowledge, Attitudes, Practice ,Asia ,animal structures ,Health Personnel ,education ,MEDLINE ,Advance Care Planning ,03 medical and health sciences ,0302 clinical medicine ,Nursing ,stomatognathic system ,SDG 3 - Good Health and Well-being ,Health care ,Humans ,Medicine ,Narrative ,030212 general & internal medicine ,General Nursing ,Operationalization ,business.industry ,Health Policy ,Capacity building ,General Medicine ,Directive ,humanities ,bacteria ,Geriatrics and Gerontology ,Thematic analysis ,Advance Directives ,business ,030217 neurology & neurosurgery - Abstract
Objective: The value of advance care planning (ACP) for patients with life-limiting illnesses is widely recognized but Asian health care professionals' (HCPs') perspectives on ACP have received little systematic attention. We aim to synthesize evidence regarding Asian HCPs’ knowledge of, attitudes toward, and experiences with ACP. Design: Systematic review with narrative synthesis and stepwise thematic analysis. Setting and Participants: HCPs in southern, eastern, and southeastern Asia. Methods: Studies from inception to September 2019 were identified from English-language searches of Embase, MEDLINE, Web of Science, and Google Scholar with reference-chaining and hand-searching. Two investigators independently screened and assessed the risk of bias in all original studies reporting HCPs’ knowledge of, attitudes toward, and experiences with ACP, including their perspectives toward barriers and facilitators of ACP. Results: Fifty-one studies were included; 42 were quantitative, 43 had been conducted in high-income countries, and 36 were of good quality. Twenty-six studies operationalized ACP as the completion of an advance directive rather than a value-exploration process. Thirteen studies reported knowledge, 44 attitudes, 29 experiences, and 36 barriers and facilitators of ACP. Asian HCPs addressed the essential role of families in ACP. They acknowledge the importance of ACP but rarely engage the patient in it. They considered ACP difficult to initiate, partly because of their lack of knowledge and skills in ACP, personal uneasiness to conduct ACP, fear of conflicts with family members and their legal consequences, and the lack of a standard system for ACP. Most studies indicated HCPs’ low engagement and late initiation of ACP. Conclusions and Implications: Despite acknowledging its importance, Asian HCPs felt that engaging in ACP is challenging. Capacity building for ACP in Asia should focus on culturally adapting ACP models concerning the essential role of the family in Asia, education for HCPs and the public, and providing institutional support for ACP.
- Published
- 2021
49. Preparedness and capacity of indian palliative care services to respond to the COVID-19 pandemic: An online rapid assessment survey
- Author
-
Emmanuel Luyirika, Sushma Bhatnagar, Asha Albuquerque Pai, Eve Namisango, Richard Harding, Carlo Peruselli, Cheng Pei Lin, Massimo Costantini, Sabah Boufkhed, Irene J Higginson, Naveen Salins, Katherine E Sleeman, and Maria L. Ekstrand
- Subjects
Palliative care ,India ,International Health Regulations ,03 medical and health sciences ,0302 clinical medicine ,030502 gerontology ,Pandemic ,Infection control ,Medicine ,Service (business) ,lcsh:R5-920 ,palliative care ,Descriptive statistics ,business.industry ,pandemic ,Health Policy ,Public Health, Environmental and Occupational Health ,COVID-19 ,medicine.disease ,preparedness ,030220 oncology & carcinogenesis ,Preparedness ,Scale (social sciences) ,Original Article ,Medical emergency ,lcsh:Medicine (General) ,0305 other medical science ,business - Abstract
Background: COVID-19 has been causing a high burden of suffering for patients and families. There is limited evidence on the preparedness of Indian palliative care services for the pandemic. Aim: This study aimed to assess the preparedness and capacity of Indian palliative care services in response to the COVID-19 pandemic. Methods: A cross-sectional online survey was developed based on prior evidence and international health regulations. It was emailed to the Indian Palliative Care Association members and investigators' professional networks in India. One participant per palliative care service was requested. Descriptive analysis was used. Results: Representatives of 78 palliative care services completed the survey. Three in four services had COVID-19 case definition and adapted their protocols for infection control (75%). About half of the services (55%) reported concerns about achieving appropriate hand hygiene in the community. More than half of the services (59%) had capacity to train nonspecialists for symptom control and psychological support. About half of the services reported that they had plans to redeploy staff (56%) and resources (53%) in the case of outbreaks. Two-fifths of the services used paper records to store an updated contact list of staff (40%) and did not have designated focal contacts for information update (40%). Staff anxiety related to personal infection risk and family care was relatively high (median score = 7 on a 1–10 scale). Conclusion: We recommend the following resource allocation to enable palliative care services to support the Indian health system in delivering essential care in this and future pandemics: (1) infection control, especially in the community; (2) training using existing clinical protocols to strengthen palliative care across the health system; and (3) redeployment plans.
- Published
- 2021
50. Advance Care Planning for Older People with Cancer and Its Implications in Asia: Highlighting the Mental Capacity and Relational Autonomy
- Author
-
Shao-Yi Cheng, Ping-Jen Chen, and Cheng Pei Lin
- Subjects
Gerontology ,Advance care planning ,Aging ,Health (social science) ,Population ,mental capacity ,Legislation ,Disease ,Review ,lcsh:Geriatrics ,relational autonomy ,03 medical and health sciences ,0302 clinical medicine ,Intervention (counseling) ,Health care ,Medicine ,cancer ,030212 general & internal medicine ,education ,advance care planning ,Family values ,education.field_of_study ,business.industry ,Preference ,lcsh:RC952-954.6 ,ageing ,030220 oncology & carcinogenesis ,Geriatrics and Gerontology ,business - Abstract
With dramatically increasing proportions of older people, global ageing has remarkably influenced healthcare services and policy making worldwide. Older people represent the majority of patients with cancer, leading to the increasing demand of healthcare due to more comorbidities and inherent frailty. The preference of older people with cancer are often ignored, and they are considered incapable of making choices for themselves, particularly medical decisions. This might impede the provision of their preferred care and lead to poor healthcare outcomes. Advance care planning (ACP) is considered an effective intervention to assist older people to think ahead and make a choice in accordance with their wishes when they possess capacity to do so. The implementation of ACP can potentially lead to positive impact for patients and families. However, the assessment of mental capacity among older adults with cancer might be a crucial concern when implementing ACP, as loss of mental capacity occurs frequently during disease deterioration and functional decline. This article aims to answer the following questions by exploring the existing evidence. How does ACP develop for older people with cancer? How can we measure mental capacity and what kind of principles for assessment we should apply? What are the facilitators and barriers when implementing an ACP in this population? Furthermore, a discussion about cultural adaptation and relevant legislation in Asia is elucidated for better understanding about its cultural appropriateness and the implications. Finally, recommendations in relation to early intervention with routine monitoring and examination of capacity assessment in clinical practice when delivering ACP, reconciling patient autonomy and family values by applying the concept of relational autonomy, and a corresponding legislation and public education should be in place in Asia. More research on ACP and capacity assessment in different cultural contexts and policy frameworks is highlighted as crucial factors for successful implementation of ACP.
- Published
- 2018
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