7 results on '"Cheng ATL"'
Search Results
2. Juvenile recurrent respiratory papillomatosis: 10-year audit and Australian prevalence estimates
- Author
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Novakovic, D, Cheng, ATL, Baguley, K, Walker, P, Harrison, H, Soma, M, Malloy, M, Brotherton, JML, Novakovic, D, Cheng, ATL, Baguley, K, Walker, P, Harrison, H, Soma, M, Malloy, M, and Brotherton, JML
- Abstract
OBJECTIVES/HYPOTHESIS: To estimate the prevalence of juvenile onset recurrent respiratory papillomatosis (RRP) in Australia, describe its epidemiological profile, and assess the positive predictive value of International Classification of Disease, 10th revision (ICD-10) code D14.1 (benign neoplasm of larynx) in children for hospitalization due to RRP. STUDY DESIGN: Retrospective case series. METHODS: Retrospective case review undertaken at the three tertiary pediatric hospitals in New South Wales (Australia's largest state), by reviewing medical records of patients aged 0 to 16 years admitted during 2000-2009 containing the ICD-10 Australian modification code D14.1 or other possible disease (D14.2-4, D14.3, D14.4) and RRP-related procedure codes. For RRP diagnoses, we recorded treatment dates, length of stay, extent of disease, and surgical and adjuvant treatments. The positive predictive value (PPV) of code D14.1 and median number of hospitalizations per year were applied to national hospital separations data from 2000/2001 to 2012/2013 to estimate disease prevalence. RESULTS: We identified 30 cases of RRP using code D14.1, which had a PPV of 98.1%, with no further cases identified using other codes. Fifty-seven percent of cases were female, median age of onset was 36 months, and median treatment duration was 36 months (mean = 40 months, range = 1-118). There was one patient death. Between 2000 and 2013, the estimated national prevalence rate was 0.81 per 100,000 aged < 15 years, peaking at age 5 to 9 years (1.1 per 100,000). CONCLUSIONS: RRP prevalence can be monitored after human papillomavirus vaccination programs using routine hospital data. LEVEL OF EVIDENCE: 4 Laryngoscope, 126:2827-2832, 2016.
- Published
- 2016
3. I17 Reduced rates of juvenile onset recurrent respiratory papillomatosis in australia after implementation of a national hpv vaccination program
- Author
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Zurynski, Y, Brotherton, JML, Novakovic, D, Cheng, ATL, Booy, R, Berkowitz, R, Garland, SM, Elliott, E, and Black, R
- Abstract
AimsJuvenile onset Recurrent Respiratory Papillomatosis (JoRRP) is a rare chronic disease caused by human papillomavirus (HPV) types 6 and 11. Children with RRP require multiple surgical interventions; tracheostomy may be needed and sometimes the disease is fatal. Infections are now preventable through HPV vaccination. Following an extensive quadrivalent HPV vaccine catch-up program for females aged 12–26 years in 2007–2009, in Australia, we aimed to monitor the changes in incidence and demographics of JoRRP over time.MethodsThe Australian Paediatric Surveillance Unit (APSU) conducted national surveillance for JRRoP using its well established reporting system. In addition to the ~1450 paediatricians who report to the APSU each month, paediatric otorhinolaryngologists were also enrolled in the APSU and offered HPV typing. We report findings for the five-year period to end 2016.ResultsThe average annual incidence rate was 0.0715 per 1 00 000 children aged <16 years. The largest number of cases was reported in the first year, with decreasing annual frequency thereafter. The rate declined significantly from 0.163 per 1 00 000 in 2012 to 0.024 per 1 00 000 in 2016 (p=0.034). Among the 15 incident cases 60% male, 60% were first born children and 13 (87%) were born vaginally. None of the mothers of these children had received the HPV vaccine before pregnancy, and 3 (20%) of the mothers had a history of genital warts. Seven genotyped cases were positive for HPV including 4 that were HPV6 positive and 3 that were HPV11 positive.ConclusionTo our knowledge this is the first report internationally documenting decline in JoRRP incidence in children following a quadrivalent HPV vaccination program.
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- 2018
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4. Management of Recurrent and Delayed Post-Tonsillectomy and Adenoidectomy Hemorrhage in Children.
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Cheung PKF, Walton J, Hobson ML, Taylor P, Chin M, Boardman S, Cheng ATL, and Birman CS
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- Child, Humans, Adenoidectomy adverse effects, Retrospective Studies, Postoperative Hemorrhage epidemiology, Postoperative Hemorrhage etiology, Postoperative Hemorrhage therapy, Risk Factors, Tonsillectomy adverse effects
- Abstract
Objective: To review our experience on post-tonsillectomy and/or adenoidectomy hemorrhage (PTAH) at a tertiary pediatric referral hospital and to evaluate the management and risk factors for recurrent postoperative hemorrhage and for delayed bleeding after day 14., Methods: A retrospective chart review was performed for all pediatric patients admitted to The Children's Hospital at Westmead for PTAH between July 01, 2014, and June 30, 2019. Patients with recurrent hemorrhage and those with bleeding after day 14 were selected for subanalysis., Results: Of the 291 patients admitted for PTAH, 31 (11%) patients had recurrent postoperative hemorrhage, and 11 (4%) patients had delayed bleeding after day 14. Surgical intervention for cessation of hemorrhage was required in 88 (30%) patients, including 2 patients who required return to the theater more than once. Nine (3%) patients received blood transfusions. The average number of days between bleeding episodes was 4 days. Recurrent postoperative hemorrhage occurred in 8.5% of patients who were managed operatively at their first presentation compared to 11.4% of patients who were managed nonoperatively (odds ratio: 1.1; 95% confidence interval 0.43-2.8). No association was found between abnormal coagulation profile, surgical indication, and risk of delayed postoperative hemorrhage., Conclusions: Recurrent or delayed postoperative hemorrhage represents a small proportion of children with postoperative bleeding and cannot be reliably predicted. Management of first presentations with either a conservative or a surgical approach is reasonable since the risk of recurrent of PTAH may be unrelated to the choice of management at initial presentation. Careful preoperative counseling of patients and their families is important to help set expectations in the event of PTAH.
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- 2023
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5. Complications and outcomes following open laryngotracheal reconstruction: A 15 year experience at an Australian paediatric tertiary referral centre.
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Cheung PKF, Koh HL, and Cheng ATL
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- Australia epidemiology, Child, Humans, Infant, Retrospective Studies, Tertiary Care Centers, Treatment Outcome, Laryngostenosis etiology, Laryngostenosis surgery, Plastic Surgery Procedures
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Objective: To report on our experience with open pediatric laryngotracheal reconstruction (LTR) with cartilage interposition grafts over the past 15 years and document setbacks and factors that affect postoperative outcomes., Method: A retrospective chart review was performed on all pediatric patients who underwent single and double-stage LTR at The Children's Hospital in Westmead between August 2004 and July 2019. The outcomes measured include the overall decannulation rate, rates of postoperative complications, need for subsequent procedures and postoperative functional results (dyspnea, stridor, voice impairment)., Results: Between August 2004 and July 2019, a total of 51 open LTRs were performed on 46 patients, with mean age 3.9 years (range 1 month to 12.1 years), including 11 revision operations (11.8%). The most common indication for surgery was subglottic stenosis, followed by bilateral vocal cord motion impairment followed by anterior glottic web. 13 cases (25.5%) were complicated by ventilator associated pneumonia in the postoperative period and 11 patients (21.6%) experienced wound complications ranging from localised wound abscess to wound dehiscence and graft failure. Patients with viral infections had an increased risk of wound dehiscence and graft failure (OR 1.8, 95% CI 1.01 - 3.23). Patients with a greater decrease in albumin in the postoperative period were more likely to have wound complications (OR 1.8; 95% CI 1.17 -2.83). Ten patients failed extubation and required a subsequent tracheostomy. Severity of stenosis, age at time of surgery, history of prematurity and revision LTR were not predictors for need for reintubation and/or tracheostomy after surgery. 23 cases (45.1%) underwent subsequent endoscopic procedures such a balloon dilatation to manage restenosis following LTR. Though 45.7% had a very good outcome, a significant group of 21% had ongoing voice issues., Conclusion: Good outcomes were achieved following open LTR for pediatric laryngotracheal stenosis despite postoperative complications. At final follow up, 33 patients (71.7%) had good exercise tolerance with no or mild stridor. Forty-one of the forty-six patients (89.1%) were successfully decannulated., (Copyright © 2021 Elsevier B.V. All rights reserved.)
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- 2021
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6. A Prospective Study of the Incidence of Juvenile-Onset Recurrent Respiratory Papillomatosis After Implementation of a National HPV Vaccination Program.
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Novakovic D, Cheng ATL, Zurynski Y, Booy R, Walker PJ, Berkowitz R, Harrison H, Black R, Perry C, Vijayasekaran S, Wabnitz D, Burns H, Tabrizi SN, Garland SM, Elliott E, and Brotherton JML
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- Adolescent, Adult, Australia epidemiology, Child, Demography, Female, Humans, Incidence, Papillomaviridae classification, Papillomaviridae genetics, Prospective Studies, Young Adult, Genotype, Immunization Programs, Papillomaviridae isolation & purification, Papillomavirus Infections epidemiology, Papillomavirus Infections prevention & control, Papillomavirus Vaccines administration & dosage, Respiratory Tract Infections epidemiology, Respiratory Tract Infections prevention & control
- Abstract
Background: Recurrent respiratory papillomatosis is a rare but morbid disease caused by human papillomavirus (HPV) types 6 and 11. Infection is preventable through HPV vaccination. Following an extensive quadrivalent HPV vaccination program (females 12-26 years in 2007-2009) in Australia, we established a method to monitor incidence and demographics of juvenile-onset recurrent respiratory papillomatosis (JORRP) cases., Methods: The Australian Paediatric Surveillance Unit undertakes surveillance of rare pediatric diseases by contacting practitioners monthly. We enrolled pediatric otorhinolaryngologists and offered HPV typing. We report findings for 5 years to end 2016., Results: The average annual incidence rate was 0.07 per 100000. The largest number of cases was reported in the first year, with decreasing annual frequency thereafter. Rates declined from 0.16 per 100000 in 2012 to 0.02 per 100000 in 2016 (P = .034). Among the 15 incident cases (60% male), no mothers were vaccinated prepregnancy, 20% had maternal history of genital warts, and 60% were first born; 13/15 were born vaginally. Genotyped cases were HPV-6 (n = 4) or HPV-11 (n = 3)., Conclusion: To our knowledge, this is the first report internationally documenting decline in JORRP incidence in children following a quadrivalent HPV vaccination program., (© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.)
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- 2018
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7. International Pediatric Otolaryngology Group: Consensus guidelines on the diagnosis and management of type I laryngeal clefts.
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Yeung JC, Balakrishnan K, Cheng ATL, Daniel SJ, Garabedian EN, Hart CK, Inglis AF Jr, Leboulanger N, Liming BJ, Moreddu E, Nicollas R, Russell JD, Rutter MJ, Sidell DR, Spratley J, Soma M, Thierry B, Thompson DM, Triglia JM, Watters K, Wyatt M, Zalzal GH, Zur KB, and Rahbar R
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- Child, Congenital Abnormalities surgery, Consensus, Guidelines as Topic, Humans, Larynx surgery, Physicians, Surveys and Questionnaires, Congenital Abnormalities diagnosis, Larynx abnormalities, Otolaryngology methods
- Abstract
Introduction: The diagnosis and management of type I laryngeal clefts can be controversial and varies across centers and surgeons. Using existing peer-reviewed literature to develop an expert-based consensus will help guide physicians in the treatment of these patients as well as develop research hypotheses to further study this condition., Objective: To provide recommendations for the diagnosis and management of type I laryngeal clefts., Methods: Determination of current expert- and literature-based recommendations, via a survey of the International Pediatric Otolaryngology Group, using a modified Delphi method., Setting: Multinational, multi-institutional, tertiary pediatric hospitals., Results: Consensus recommendations include diagnostic workup, medical management, pre-operative, intra-operative and post-operative considerations for type I laryngeal clefts., Conclusions: This guide on the diagnosis and management of patients with type I laryngeal clefts is aimed at improving patient care and promoting future hypothesis generation and research to validate the recommendations made here., (Copyright © 2017 Elsevier B.V. All rights reserved.)
- Published
- 2017
- Full Text
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